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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:ARHGEF6-TMEM48 (FusionGDB2 ID:HG9459TG55706) |
Fusion Gene Summary for ARHGEF6-TMEM48 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ARHGEF6-TMEM48 | Fusion gene ID: hg9459tg55706 | Hgene | Tgene | Gene symbol | ARHGEF6 | TMEM48 | Gene ID | 9459 | 55706 |
Gene name | Rac/Cdc42 guanine nucleotide exchange factor 6 | NDC1 transmembrane nucleoporin | |
Synonyms | COOL2|Cool-2|MRX46|PIXA|alpha-PIX|alphaPIX | NET3|TMEM48 | |
Cytomap | ('ARHGEF6','ARHGEF6')('NDC1','TMEM48') Xq26.3 | 1p32.3 | |
Type of gene | protein-coding | protein-coding | |
Description | rho guanine nucleotide exchange factor 6PAK-interacting exchange factor, alphaRac/Cdc42 guanine exchange factor (GEF) 6Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | nucleoporin NDC1nuclear division cycle 1 homologtransmembrane protein 48 | |
Modification date | 20200327 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000250617, ENST00000370620, ENST00000370622, ENST00000535227, | ||
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 6 X 7=336 |
# samples | 1 | 9 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ARHGEF6 [Title/Abstract] AND TMEM48 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ARHGEF6(135814261)-NDC1(54275419), # samples:1 ARHGEF6(135814261)-TMEM48(54275419), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | ARHGEF6-NDC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGEF6-NDC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGEF6-NDC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGEF6-NDC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGEF6-NDC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ARHGEF6-NDC1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene breakpoints across ARHGEF6 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across TMEM48 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SARC | TCGA-X6-A8C2-01A | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
ChimerDB4 | SARC | TCGA-X6-A8C2-01A | ARHGEF6 | chrX | 135814261 | - | TMEM48 | chr1 | 54275419 | - |
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Fusion Gene ORF analysis for ARHGEF6-TMEM48 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000250617 | ENST00000234725 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
5CDS-5UTR | ENST00000250617 | ENST00000537333 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
5CDS-5UTR | ENST00000370620 | ENST00000234725 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
5CDS-5UTR | ENST00000370620 | ENST00000537333 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
5CDS-5UTR | ENST00000370622 | ENST00000234725 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
5CDS-5UTR | ENST00000370622 | ENST00000537333 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
5CDS-5UTR | ENST00000535227 | ENST00000234725 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
5CDS-5UTR | ENST00000535227 | ENST00000537333 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
5CDS-intron | ENST00000250617 | ENST00000480952 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
5CDS-intron | ENST00000370620 | ENST00000480952 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
5CDS-intron | ENST00000370622 | ENST00000480952 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
5CDS-intron | ENST00000535227 | ENST00000480952 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
Frame-shift | ENST00000250617 | ENST00000371429 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
Frame-shift | ENST00000250617 | ENST00000540001 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
In-frame | ENST00000370620 | ENST00000371429 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
In-frame | ENST00000370620 | ENST00000540001 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
In-frame | ENST00000370622 | ENST00000371429 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
In-frame | ENST00000370622 | ENST00000540001 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
In-frame | ENST00000535227 | ENST00000371429 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
In-frame | ENST00000535227 | ENST00000540001 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000370620 | ARHGEF6 | chrX | 135814261 | - | ENST00000371429 | NDC1 | chr1 | 54275419 | - | 4515 | 683 | 715 | 2004 | 429 |
ENST00000370620 | ARHGEF6 | chrX | 135814261 | - | ENST00000540001 | NDC1 | chr1 | 54275419 | - | 4402 | 683 | 715 | 1608 | 297 |
ENST00000370622 | ARHGEF6 | chrX | 135814261 | - | ENST00000371429 | NDC1 | chr1 | 54275419 | - | 4530 | 698 | 730 | 2019 | 429 |
ENST00000370622 | ARHGEF6 | chrX | 135814261 | - | ENST00000540001 | NDC1 | chr1 | 54275419 | - | 4417 | 698 | 730 | 1623 | 297 |
ENST00000535227 | ARHGEF6 | chrX | 135814261 | - | ENST00000371429 | NDC1 | chr1 | 54275419 | - | 4645 | 813 | 845 | 2134 | 429 |
ENST00000535227 | ARHGEF6 | chrX | 135814261 | - | ENST00000540001 | NDC1 | chr1 | 54275419 | - | 4532 | 813 | 845 | 1738 | 297 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000370620 | ENST00000371429 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - | 0.001249368 | 0.99875057 |
ENST00000370620 | ENST00000540001 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - | 0.010287642 | 0.98971236 |
ENST00000370622 | ENST00000371429 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - | 0.001078712 | 0.9989213 |
ENST00000370622 | ENST00000540001 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - | 0.008816208 | 0.99118376 |
ENST00000535227 | ENST00000371429 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - | 0.001363887 | 0.99863607 |
ENST00000535227 | ENST00000540001 | ARHGEF6 | chrX | 135814261 | - | NDC1 | chr1 | 54275419 | - | 0.011301254 | 0.9886988 |
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Fusion Genomic Features for ARHGEF6-TMEM48 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for ARHGEF6-TMEM48 |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:135814261/:54275419) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ARHGEF6 | chrX:135814261 | chr1:54275419 | ENST00000250617 | - | 6 | 22 | 160_219 | 244 | 777.0 | Domain | SH3 |
Hgene | ARHGEF6 | chrX:135814261 | chr1:54275419 | ENST00000250617 | - | 6 | 22 | 1_111 | 244 | 777.0 | Domain | Calponin-homology (CH) |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000371429 | 5 | 18 | 247_272 | 234 | 675.0 | Topological domain | Perinuclear space | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000371429 | 5 | 18 | 294_674 | 234 | 675.0 | Topological domain | Cytoplasmic | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000540001 | 5 | 17 | 247_272 | 234 | 1297.0 | Topological domain | Perinuclear space | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000540001 | 5 | 17 | 294_674 | 234 | 1297.0 | Topological domain | Cytoplasmic | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000371429 | 5 | 18 | 273_293 | 234 | 675.0 | Transmembrane | Helical%3B Name%3D6 | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000540001 | 5 | 17 | 273_293 | 234 | 1297.0 | Transmembrane | Helical%3B Name%3D6 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ARHGEF6 | chrX:135814261 | chr1:54275419 | ENST00000250617 | - | 6 | 22 | 241_421 | 244 | 777.0 | Domain | DH |
Hgene | ARHGEF6 | chrX:135814261 | chr1:54275419 | ENST00000250617 | - | 6 | 22 | 443_548 | 244 | 777.0 | Domain | PH |
Hgene | ARHGEF6 | chrX:135814261 | chr1:54275419 | ENST00000370620 | - | 5 | 21 | 160_219 | 90 | 623.0 | Domain | SH3 |
Hgene | ARHGEF6 | chrX:135814261 | chr1:54275419 | ENST00000370620 | - | 5 | 21 | 1_111 | 90 | 623.0 | Domain | Calponin-homology (CH) |
Hgene | ARHGEF6 | chrX:135814261 | chr1:54275419 | ENST00000370620 | - | 5 | 21 | 241_421 | 90 | 623.0 | Domain | DH |
Hgene | ARHGEF6 | chrX:135814261 | chr1:54275419 | ENST00000370620 | - | 5 | 21 | 443_548 | 90 | 623.0 | Domain | PH |
Hgene | ARHGEF6 | chrX:135814261 | chr1:54275419 | ENST00000370622 | - | 5 | 21 | 160_219 | 90 | 623.0 | Domain | SH3 |
Hgene | ARHGEF6 | chrX:135814261 | chr1:54275419 | ENST00000370622 | - | 5 | 21 | 1_111 | 90 | 623.0 | Domain | Calponin-homology (CH) |
Hgene | ARHGEF6 | chrX:135814261 | chr1:54275419 | ENST00000370622 | - | 5 | 21 | 241_421 | 90 | 623.0 | Domain | DH |
Hgene | ARHGEF6 | chrX:135814261 | chr1:54275419 | ENST00000370622 | - | 5 | 21 | 443_548 | 90 | 623.0 | Domain | PH |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000371429 | 5 | 18 | 136_165 | 234 | 675.0 | Topological domain | Perinuclear space | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000371429 | 5 | 18 | 187_225 | 234 | 675.0 | Topological domain | Cytoplasmic | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000371429 | 5 | 18 | 1_24 | 234 | 675.0 | Topological domain | Cytoplasmic | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000371429 | 5 | 18 | 46_68 | 234 | 675.0 | Topological domain | Perinuclear space | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000371429 | 5 | 18 | 90_114 | 234 | 675.0 | Topological domain | Cytoplasmic | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000540001 | 5 | 17 | 136_165 | 234 | 1297.0 | Topological domain | Perinuclear space | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000540001 | 5 | 17 | 187_225 | 234 | 1297.0 | Topological domain | Cytoplasmic | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000540001 | 5 | 17 | 1_24 | 234 | 1297.0 | Topological domain | Cytoplasmic | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000540001 | 5 | 17 | 46_68 | 234 | 1297.0 | Topological domain | Perinuclear space | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000540001 | 5 | 17 | 90_114 | 234 | 1297.0 | Topological domain | Cytoplasmic | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000371429 | 5 | 18 | 115_135 | 234 | 675.0 | Transmembrane | Helical%3B Name%3D3 | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000371429 | 5 | 18 | 166_186 | 234 | 675.0 | Transmembrane | Helical%3B Name%3D4 | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000371429 | 5 | 18 | 226_246 | 234 | 675.0 | Transmembrane | Helical%3B Name%3D5 | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000371429 | 5 | 18 | 25_45 | 234 | 675.0 | Transmembrane | Helical%3B Name%3D1 | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000371429 | 5 | 18 | 69_89 | 234 | 675.0 | Transmembrane | Helical%3B Name%3D2 | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000540001 | 5 | 17 | 115_135 | 234 | 1297.0 | Transmembrane | Helical%3B Name%3D3 | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000540001 | 5 | 17 | 166_186 | 234 | 1297.0 | Transmembrane | Helical%3B Name%3D4 | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000540001 | 5 | 17 | 226_246 | 234 | 1297.0 | Transmembrane | Helical%3B Name%3D5 | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000540001 | 5 | 17 | 25_45 | 234 | 1297.0 | Transmembrane | Helical%3B Name%3D1 | |
Tgene | NDC1 | chrX:135814261 | chr1:54275419 | ENST00000540001 | 5 | 17 | 69_89 | 234 | 1297.0 | Transmembrane | Helical%3B Name%3D2 |
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Fusion Gene Sequence for ARHGEF6-TMEM48 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>6336_6336_1_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000370620_NDC1_chr1_54275419_ENST00000371429_length(transcript)=4515nt_BP=683nt AGTTTCGCCCTGGTGGCGGCCGCGCTCAGGGCAGGGTCCCAGCTCCGGCTGGGTTGATCTGTTCCCGCAGCCTTGGCACAGGCTTGCCCG CCCGCTCGCCGGCCCCGTGACTCGGGAGGGCGAACGGCTTCCAGGAGGCGGCGGCGGCGCGGCTGGAGTGAGGGAGCAGCTGGAGGACAG GCGGGCAGCGGCCGAGCCAGATATTTGATCCTGATGACCTTTATTCAGGGGTCAATTTCTCCAAGGTACTGAGTACTCTTTTAGCTGTCA ACAAAGCAACAGAAGATCAGCTATCAGAAAGACCATGTGGACGTTCCTCTTCTCTTAGTGCTGCTAATACTTCTCAGACAAACCCACAGG GAGCAGTTTCTAGCACAGTTTCAGGGCTGCAAAGGCAGTCAAAGACAGTGGAGATGACGGAAAATGGAAGTCATCAGTTGATAGTAAAAG CAAGATTCAACTTTAAGCAGACTAATGAGGATGAACTGTCAGTTTGTAAGGGGGACATCATTTACGTCACACGAGTTGAAGAAGGAGGCT GGTGGGAAGGCACATTAAATGGGAGAACAGGCTGGTTCCCCAGTAATTATGTCCGTGAAATTAAATCCAGTGAGAGACCTCTCTCCCCAA AAGCCGTCAAAGGATTTGAAACTGCTCCACTTACCAAGAATTATTATACTGTGGCTATATTCCCAAAGCTTGGATTAGCACTGCTATGAA CCTTCACATAGATGAGCAGGTTCATAGGCCACTTGACACAGTGAGTGGCCTCTTAAATCTCTCGTTACTCTACCATGTCTGGCTGTGTGG TGTCTTTCTCCTGACGACTTGGTATGTCTCATGGATACTCTTCAAAATCTATGCCACAGAGGCTCATGTGTTTCCTGTTCAACCACCATT TGCAGAAGGGTCAGATGAGTGCCTTCCAAAAGTGTTAAATAGCAATCCTCCCCCCATCATAAAGTATTTAGCCTTGCAGGACCTGATGTT GCTTTCTCAATATTCTCCTTCACGAAGACAAGAAGTTTTCAGCCTCAGCCAACCAGGTGGACATCCCCACAATTGGACAGCCATTTCAAG GGAGTGTTTGAATCTTTTAAATGGTATGACTCAGAAACTGATTCTCTATCAAGAAGCTGCTGCTACGAATGGGAGAGTGTCTTCATCTTA CCCAGTGGAACCTAAGAAATTAAATTCTCCAGAAGAAACTGCTTTTCAGACACCAAAATCTAGCCAGATGCCTCGGCCTTCAGTGCCACC ATTAGTTAAAACATCACTGTTTTCTTCAAAATTATCTACACCTGATGTTGTGAGCCCATTTGGGACCCCATTTGGCTCTAGTGTAATGAA TCGGATGGCTGGAATTTTTGATGTAAACACCTGCTATGGGTCACCGCAAAGTCCTCAGCTAATAAGAAGGGGGCCAAGATTGTGGACATC AGCTTCTGATCAGCAAATGACTGAATTTTCTAATCCTTCTCCATCTACCTCTATTAGTGCTGAGGGTAAGACAATGAGACAACCCAGTGT GATTTATTCATGGATTCAGAATAAACGTGAACAGATTAAGAATTTCTTGTCAAAACGGGTGCTGATAATGTATTTTTTCAGTAAGCACCC AGAGGCCTCCATTCAGGCTGTTTTTTCAGATGCCCAAATGCATATTTGGGCATTAGAAGGTCTGTCGCACTTAGTAGCAGCATCATTTAC AGAGGATAGATTTGGAGTTGTCCAGACGACACTACCAGCTATCCTTAATACTTTGTTGACACTGCAAGAGGCAGTCGACAAGTACTTTAA GCTTCCTCATGCTTCCAGTAAACCACCCCGGATTTCAGGAAGCCTTGTGGACACTTCATATAAAACATTAAGATTTGCATTCAGAGCATC ACTGAAAACTGCCATCTATCGAATAACTACTACATTTGGTGAACATCTGAATGCTGTGCAAGCATCTGCAGAACATCAGAAAAGACTTCA ACAGTTCTTGGAGTTCAAAGAATAGTTAAGTAATATAAACTGTGTTCATTACACTGCTGATACAACTACAGATGGGACAGTAAATGTTCA GCATTCTTGGATCAGAAGAAAACGGACTAATTAGATGCTTCCTTTGTCGTGGTGGTTGCTTTGAAAACTATACTTTAATGGGAGAAATCA TGGAAAGAAATTCTCAACAGAATAACTGAAAACTGCCTTTTCTGTACCGATTGCTTTTTGTGTGTGTGGTATAATAAAATCTTTATTCAA TTTTACAGAAGCATTGATGGCAGTCGAAATGTCTCTAGCTCATATAACTTAATAGTAATAACTAAAAAACTTTTAGAATTTACTTTTGAA AGGAGGGAAGCCAGTTCTGAAATGAGTATAGGTTGATTTCATAGTCTTCTTAATTAAGAGTTTAGCTCTTTGTAAACTCAAAATACATAA ACTTTTTAAGTGTAGTTTCATTTACTGAAGGATAAAAATGGTAACAGTGCAGCAATATTCACAAAAAATATTGTCTAACGGACATATTTT GTTAATCTGTTAGGTTGGGTTTTTGTTTCCAGGGACAAATTAAATTTGTATGATTACCCAAAAAAGGGTCTCAGTTTACAGATGCTAACT CTATATAAAGGAATGTGGAAAAACTCAGTTCTTAAGTTACAAGATTAAAAATTCACATTTGGTCTTTAAGAAACAATTGACTGACATCTA TGAATTTATTTTGTATCATGCTAGTAAACACGAAGTATTAATGTATGGGTATTTTCCCAGCTAGTTTTGCTTTCTTTTTCTGGAGCAAAA CATTAAGTGATTGCAGAGTTTTTCAAGCAAGAGAAAAAGGTTTGCAAAAAAACCCAGGAAATGTTCCCTTTTTTCCCCACCATTCATCTT CATTAGATCAAATTCTGTGAAACTTGTCTGGTCTCTCAAAGGGAGCAGCCTCTGTAGTGTTAAATGGCTAATTAAAATAGGAAGATCTTT ATAGCCAGAAACAACTTAGTCATCAAATAGCAAGTGAAACCAAAACGTCAGAGGGATTACTGTACTTGGAAGTATGTTGTGTGTCCCAAA TGTGAACGAAGTATTGTTAGAATTTATTAGATCAGCTTCTTTGGAGATCAAAGATTGGAAATCCTAGTCATAGATATTCACTGGACTGGC TTTGGACTGAAATGCTCCTTTGTAATTCTTTTCCTATTGTCTTTTCCTTCTAGTGTCCCAAAATATTTTCTTTAAAGTCAGCACAGTACT GTATATGAATCTTTAATGTGGTATCATATATGTCTACTTTTGTCTGATTCATCGATGTATTATATCTTTATAATTGAATATTTTAGCTCC GGGTCCTGTTGCCCCTTCAAGCAGTACATGCCAAATTATAAATAGGTGCTACTGGCCTTGAGCATATCACTGTGGGACAGTTCCCCAATT GTCAAGTGTTTAGATATGTAGACTATTGCCATTTGTTTTTTTGTTTTGGTTTTGCTTTGTGTCTGAAGCTGAATTGATTTCTTTTTTTTG AATGTGAAAGTTGAATTTCAAACGTAGTCATTTCTTACAGATGGCCAAGACAGAAAATTGTGGCTAGGTTGACTGAGAACTGTTGTCTTC CATGTATTAACACAATTAAGCTTTTTATATTCCACTCTCTGTGCTGACCCTGGCTGAGGCATTTTGGGAGACAAGGACTCTGAATCTTCT GCTTCCATTAAAGAAGAACTGTGATATTCAACATTGGATTTCTGAGAATAAAGATAGGATGATTCCTTTGAACTTTGACTTACTTGTATA AAATGTCCAGCTAGGTTAGGTTTTTGCCATTTCCTATATACTTTGGGTAAAGCTACATTTGATGAGCAATGTGAATGTTTCTGAGAATGT TCATTCCTGTTTTCTCTTAAGAGAATGTGCTGTGTACTAAATACAGGCCACATAGTGTCTGCCTGTTGAAGATCTGGAAACTGCCTCCCC AGATCTGTATTGTATTTGGTAGGTAAGGGGGTCAGTTTCTTTTTCTCATTGTGTGTTGATAATCTACACACCATCTGTTGGAACCAGGGT GTTATTATGGGGAACTCCTCCTGTGTACTAGGAGGAGGACCTTAGGGAGACCAAGAGGAGAGAAGCATTTCCTTTGATGAAGTCACATCC TGTCTATGAGCCCACTAATGCTGTAACATTGGCCTGAAAGAGAGTGTTCTTTAAAAGCCTTTCTCGGCTGTTAGTATAAAAACATGATGG TATCAGCTCTTAGCATGTTTGCTTGACCCTTATGGAAGGTATAAATCCACAGAACTTCCTTCCCAGAGAACTGGGAAATTGTCCTAGAAA TAAACCTTGTACAGTTGAGTGGACATGGATAAGCAACAATTTGTTACTTTGCAGGATTTGTTCCTTGGTAATTGTTTGGTGTGTCATCCT GTAAATATTCATGATAGTCTGTTTATATCCTTTTGTATATCGTTGATACTGGATTGGGTAGAAAAATAAATTGGCAATTTAAAAAAATGG >6336_6336_1_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000370620_NDC1_chr1_54275419_ENST00000371429_length(amino acids)=429AA_BP= MNLHIDEQVHRPLDTVSGLLNLSLLYHVWLCGVFLLTTWYVSWILFKIYATEAHVFPVQPPFAEGSDECLPKVLNSNPPPIIKYLALQDL MLLSQYSPSRRQEVFSLSQPGGHPHNWTAISRECLNLLNGMTQKLILYQEAAATNGRVSSSYPVEPKKLNSPEETAFQTPKSSQMPRPSV PPLVKTSLFSSKLSTPDVVSPFGTPFGSSVMNRMAGIFDVNTCYGSPQSPQLIRRGPRLWTSASDQQMTEFSNPSPSTSISAEGKTMRQP SVIYSWIQNKREQIKNFLSKRVLIMYFFSKHPEASIQAVFSDAQMHIWALEGLSHLVAASFTEDRFGVVQTTLPAILNTLLTLQEAVDKY -------------------------------------------------------------- >6336_6336_2_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000370620_NDC1_chr1_54275419_ENST00000540001_length(transcript)=4402nt_BP=683nt AGTTTCGCCCTGGTGGCGGCCGCGCTCAGGGCAGGGTCCCAGCTCCGGCTGGGTTGATCTGTTCCCGCAGCCTTGGCACAGGCTTGCCCG CCCGCTCGCCGGCCCCGTGACTCGGGAGGGCGAACGGCTTCCAGGAGGCGGCGGCGGCGCGGCTGGAGTGAGGGAGCAGCTGGAGGACAG GCGGGCAGCGGCCGAGCCAGATATTTGATCCTGATGACCTTTATTCAGGGGTCAATTTCTCCAAGGTACTGAGTACTCTTTTAGCTGTCA ACAAAGCAACAGAAGATCAGCTATCAGAAAGACCATGTGGACGTTCCTCTTCTCTTAGTGCTGCTAATACTTCTCAGACAAACCCACAGG GAGCAGTTTCTAGCACAGTTTCAGGGCTGCAAAGGCAGTCAAAGACAGTGGAGATGACGGAAAATGGAAGTCATCAGTTGATAGTAAAAG CAAGATTCAACTTTAAGCAGACTAATGAGGATGAACTGTCAGTTTGTAAGGGGGACATCATTTACGTCACACGAGTTGAAGAAGGAGGCT GGTGGGAAGGCACATTAAATGGGAGAACAGGCTGGTTCCCCAGTAATTATGTCCGTGAAATTAAATCCAGTGAGAGACCTCTCTCCCCAA AAGCCGTCAAAGGATTTGAAACTGCTCCACTTACCAAGAATTATTATACTGTGGCTATATTCCCAAAGCTTGGATTAGCACTGCTATGAA CCTTCACATAGATGAGCAGGTTCATAGGCCACTTGACACAGTGAGTGGCCTCTTAAATCTCTCGTTACTCTACCATGTCTGGCTGTGTGG TGTCTTTCTCCTGACGACTTGGTATGTCTCATGGATACTCTTCAAAATCTATGCCACAGAGGCTCATGTGTTTCCTGTTCAACCACCATT TGCAGAAGGGTCAGATGAGTGCCTTCCAAAAGTGTTAAATAGCAATCCTCCCCCCATCATAAAGTATTTAGCCTTGCAGGACCTGATGTT GCTTTCTCAATATTCTCCTTCACGAAGACAAGAAGTTTTCAGCCTCAGCCAACCAGGTGGACATCCCCACAATTGGACAGCCATTTCAAG GGAGTGTTTGAATCTTTTAAATGGTATGACTCAGAAACTGATTCTCTATCAAGAAGCTGCTGCTACGAATGGGAGAGTGTCTTCATCTTA CCCAGTGGAACCTAAGAAATTAAATTCTCCAGAAGAAACTGCTTTTCAGACACCAAAATCTAGCCAGATGCCTCGGCCTTCAGTGCCACC ATTAGTTAAAACATCACTGTTTTCTTCAAAATTATCTACACCTGATGTTGTGAGCCCATTTGGGACCCCATTTGGCTCTAGTGTAATGAA TCGGATGGCTGGAATTTTTGATGTAAACACCTGCTATGGGTCACCGCAAAGTCCTCAGCTAATAAGAAGGGGGCCAAGATTGTGGACATC AGCTTCTGATCAGCAAATGACTGAATTTTCTAATCCTTCTCCATCTACCTCTATTAGTGCTGAGGCACCCAGAGGCCTCCATTCAGGCTG TTTTTTCAGATGCCCAAATGCATATTTGGGCATTAGAAGGTCTGTCGCACTTAGTAGCAGCATCATTTACAGAGGATAGATTTGGAGTTG TCCAGACGACACTACCAGCTATCCTTAATACTTTGTTGACACTGCAAGAGGCAGTCGACAAGTACTTTAAGCTTCCTCATGCTTCCAGTA AACCACCCCGGATTTCAGGAAGCCTTGTGGACACTTCATATAAAACATTAAGATTTGCATTCAGAGCATCACTGAAAACTGCCATCTATC GAATAACTACTACATTTGGTGAACATCTGAATGCTGTGCAAGCATCTGCAGAACATCAGAAAAGACTTCAACAGTTCTTGGAGTTCAAAG AATAGTTAAGTAATATAAACTGTGTTCATTACACTGCTGATACAACTACAGATGGGACAGTAAATGTTCAGCATTCTTGGATCAGAAGAA AACGGACTAATTAGATGCTTCCTTTGTCGTGGTGGTTGCTTTGAAAACTATACTTTAATGGGAGAAATCATGGAAAGAAATTCTCAACAG AATAACTGAAAACTGCCTTTTCTGTACCGATTGCTTTTTGTGTGTGTGGTATAATAAAATCTTTATTCAATTTTACAGAAGCATTGATGG CAGTCGAAATGTCTCTAGCTCATATAACTTAATAGTAATAACTAAAAAACTTTTAGAATTTACTTTTGAAAGGAGGGAAGCCAGTTCTGA AATGAGTATAGGTTGATTTCATAGTCTTCTTAATTAAGAGTTTAGCTCTTTGTAAACTCAAAATACATAAACTTTTTAAGTGTAGTTTCA TTTACTGAAGGATAAAAATGGTAACAGTGCAGCAATATTCACAAAAAATATTGTCTAACGGACATATTTTGTTAATCTGTTAGGTTGGGT TTTTGTTTCCAGGGACAAATTAAATTTGTATGATTACCCAAAAAAGGGTCTCAGTTTACAGATGCTAACTCTATATAAAGGAATGTGGAA AAACTCAGTTCTTAAGTTACAAGATTAAAAATTCACATTTGGTCTTTAAGAAACAATTGACTGACATCTATGAATTTATTTTGTATCATG CTAGTAAACACGAAGTATTAATGTATGGGTATTTTCCCAGCTAGTTTTGCTTTCTTTTTCTGGAGCAAAACATTAAGTGATTGCAGAGTT TTTCAAGCAAGAGAAAAAGGTTTGCAAAAAAACCCAGGAAATGTTCCCTTTTTTCCCCACCATTCATCTTCATTAGATCAAATTCTGTGA AACTTGTCTGGTCTCTCAAAGGGAGCAGCCTCTGTAGTGTTAAATGGCTAATTAAAATAGGAAGATCTTTATAGCCAGAAACAACTTAGT CATCAAATAGCAAGTGAAACCAAAACGTCAGAGGGATTACTGTACTTGGAAGTATGTTGTGTGTCCCAAATGTGAACGAAGTATTGTTAG AATTTATTAGATCAGCTTCTTTGGAGATCAAAGATTGGAAATCCTAGTCATAGATATTCACTGGACTGGCTTTGGACTGAAATGCTCCTT TGTAATTCTTTTCCTATTGTCTTTTCCTTCTAGTGTCCCAAAATATTTTCTTTAAAGTCAGCACAGTACTGTATATGAATCTTTAATGTG GTATCATATATGTCTACTTTTGTCTGATTCATCGATGTATTATATCTTTATAATTGAATATTTTAGCTCCGGGTCCTGTTGCCCCTTCAA GCAGTACATGCCAAATTATAAATAGGTGCTACTGGCCTTGAGCATATCACTGTGGGACAGTTCCCCAATTGTCAAGTGTTTAGATATGTA GACTATTGCCATTTGTTTTTTTGTTTTGGTTTTGCTTTGTGTCTGAAGCTGAATTGATTTCTTTTTTTTGAATGTGAAAGTTGAATTTCA AACGTAGTCATTTCTTACAGATGGCCAAGACAGAAAATTGTGGCTAGGTTGACTGAGAACTGTTGTCTTCCATGTATTAACACAATTAAG CTTTTTATATTCCACTCTCTGTGCTGACCCTGGCTGAGGCATTTTGGGAGACAAGGACTCTGAATCTTCTGCTTCCATTAAAGAAGAACT GTGATATTCAACATTGGATTTCTGAGAATAAAGATAGGATGATTCCTTTGAACTTTGACTTACTTGTATAAAATGTCCAGCTAGGTTAGG TTTTTGCCATTTCCTATATACTTTGGGTAAAGCTACATTTGATGAGCAATGTGAATGTTTCTGAGAATGTTCATTCCTGTTTTCTCTTAA GAGAATGTGCTGTGTACTAAATACAGGCCACATAGTGTCTGCCTGTTGAAGATCTGGAAACTGCCTCCCCAGATCTGTATTGTATTTGGT AGGTAAGGGGGTCAGTTTCTTTTTCTCATTGTGTGTTGATAATCTACACACCATCTGTTGGAACCAGGGTGTTATTATGGGGAACTCCTC CTGTGTACTAGGAGGAGGACCTTAGGGAGACCAAGAGGAGAGAAGCATTTCCTTTGATGAAGTCACATCCTGTCTATGAGCCCACTAATG CTGTAACATTGGCCTGAAAGAGAGTGTTCTTTAAAAGCCTTTCTCGGCTGTTAGTATAAAAACATGATGGTATCAGCTCTTAGCATGTTT GCTTGACCCTTATGGAAGGTATAAATCCACAGAACTTCCTTCCCAGAGAACTGGGAAATTGTCCTAGAAATAAACCTTGTACAGTTGAGT GGACATGGATAAGCAACAATTTGTTACTTTGCAGGATTTGTTCCTTGGTAATTGTTTGGTGTGTCATCCTGTAAATATTCATGATAGTCT >6336_6336_2_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000370620_NDC1_chr1_54275419_ENST00000540001_length(amino acids)=297AA_BP= MNLHIDEQVHRPLDTVSGLLNLSLLYHVWLCGVFLLTTWYVSWILFKIYATEAHVFPVQPPFAEGSDECLPKVLNSNPPPIIKYLALQDL MLLSQYSPSRRQEVFSLSQPGGHPHNWTAISRECLNLLNGMTQKLILYQEAAATNGRVSSSYPVEPKKLNSPEETAFQTPKSSQMPRPSV PPLVKTSLFSSKLSTPDVVSPFGTPFGSSVMNRMAGIFDVNTCYGSPQSPQLIRRGPRLWTSASDQQMTEFSNPSPSTSISAEAPRGLHS -------------------------------------------------------------- >6336_6336_3_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000370622_NDC1_chr1_54275419_ENST00000371429_length(transcript)=4530nt_BP=698nt GCCCTGACCCTGCCACTTGTGTGAAGTCAGGATCTCCTTTCCCAGGCCTCAGTTGAGTCATCTGTAAAATGAGGAGACTAGAGTAGGGGT TGGGTAATGTCTAATGGTTGTAATGTCTGTTTTTAACTTGCCCATTTCCATCAGTTTCCGCTAGGCAAAGCTTTGCATATTTAGCTGCTC AGTTGGAACTAGTAGGAAGACCAAAGAGGATTTTGATATTTGATCCTGATGACCTTTATTCAGGGGTCAATTTCTCCAAGGTACTGAGTA CTCTTTTAGCTGTCAACAAAGCAACAGAAGATCAGCTATCAGAAAGACCATGTGGACGTTCCTCTTCTCTTAGTGCTGCTAATACTTCTC AGACAAACCCACAGGGAGCAGTTTCTAGCACAGTTTCAGGGCTGCAAAGGCAGTCAAAGACAGTGGAGATGACGGAAAATGGAAGTCATC AGTTGATAGTAAAAGCAAGATTCAACTTTAAGCAGACTAATGAGGATGAACTGTCAGTTTGTAAGGGGGACATCATTTACGTCACACGAG TTGAAGAAGGAGGCTGGTGGGAAGGCACATTAAATGGGAGAACAGGCTGGTTCCCCAGTAATTATGTCCGTGAAATTAAATCCAGTGAGA GACCTCTCTCCCCAAAAGCCGTCAAAGGATTTGAAACTGCTCCACTTACCAAGAATTATTATACTGTGGCTATATTCCCAAAGCTTGGAT TAGCACTGCTATGAACCTTCACATAGATGAGCAGGTTCATAGGCCACTTGACACAGTGAGTGGCCTCTTAAATCTCTCGTTACTCTACCA TGTCTGGCTGTGTGGTGTCTTTCTCCTGACGACTTGGTATGTCTCATGGATACTCTTCAAAATCTATGCCACAGAGGCTCATGTGTTTCC TGTTCAACCACCATTTGCAGAAGGGTCAGATGAGTGCCTTCCAAAAGTGTTAAATAGCAATCCTCCCCCCATCATAAAGTATTTAGCCTT GCAGGACCTGATGTTGCTTTCTCAATATTCTCCTTCACGAAGACAAGAAGTTTTCAGCCTCAGCCAACCAGGTGGACATCCCCACAATTG GACAGCCATTTCAAGGGAGTGTTTGAATCTTTTAAATGGTATGACTCAGAAACTGATTCTCTATCAAGAAGCTGCTGCTACGAATGGGAG AGTGTCTTCATCTTACCCAGTGGAACCTAAGAAATTAAATTCTCCAGAAGAAACTGCTTTTCAGACACCAAAATCTAGCCAGATGCCTCG GCCTTCAGTGCCACCATTAGTTAAAACATCACTGTTTTCTTCAAAATTATCTACACCTGATGTTGTGAGCCCATTTGGGACCCCATTTGG CTCTAGTGTAATGAATCGGATGGCTGGAATTTTTGATGTAAACACCTGCTATGGGTCACCGCAAAGTCCTCAGCTAATAAGAAGGGGGCC AAGATTGTGGACATCAGCTTCTGATCAGCAAATGACTGAATTTTCTAATCCTTCTCCATCTACCTCTATTAGTGCTGAGGGTAAGACAAT GAGACAACCCAGTGTGATTTATTCATGGATTCAGAATAAACGTGAACAGATTAAGAATTTCTTGTCAAAACGGGTGCTGATAATGTATTT TTTCAGTAAGCACCCAGAGGCCTCCATTCAGGCTGTTTTTTCAGATGCCCAAATGCATATTTGGGCATTAGAAGGTCTGTCGCACTTAGT AGCAGCATCATTTACAGAGGATAGATTTGGAGTTGTCCAGACGACACTACCAGCTATCCTTAATACTTTGTTGACACTGCAAGAGGCAGT CGACAAGTACTTTAAGCTTCCTCATGCTTCCAGTAAACCACCCCGGATTTCAGGAAGCCTTGTGGACACTTCATATAAAACATTAAGATT TGCATTCAGAGCATCACTGAAAACTGCCATCTATCGAATAACTACTACATTTGGTGAACATCTGAATGCTGTGCAAGCATCTGCAGAACA TCAGAAAAGACTTCAACAGTTCTTGGAGTTCAAAGAATAGTTAAGTAATATAAACTGTGTTCATTACACTGCTGATACAACTACAGATGG GACAGTAAATGTTCAGCATTCTTGGATCAGAAGAAAACGGACTAATTAGATGCTTCCTTTGTCGTGGTGGTTGCTTTGAAAACTATACTT TAATGGGAGAAATCATGGAAAGAAATTCTCAACAGAATAACTGAAAACTGCCTTTTCTGTACCGATTGCTTTTTGTGTGTGTGGTATAAT AAAATCTTTATTCAATTTTACAGAAGCATTGATGGCAGTCGAAATGTCTCTAGCTCATATAACTTAATAGTAATAACTAAAAAACTTTTA GAATTTACTTTTGAAAGGAGGGAAGCCAGTTCTGAAATGAGTATAGGTTGATTTCATAGTCTTCTTAATTAAGAGTTTAGCTCTTTGTAA ACTCAAAATACATAAACTTTTTAAGTGTAGTTTCATTTACTGAAGGATAAAAATGGTAACAGTGCAGCAATATTCACAAAAAATATTGTC TAACGGACATATTTTGTTAATCTGTTAGGTTGGGTTTTTGTTTCCAGGGACAAATTAAATTTGTATGATTACCCAAAAAAGGGTCTCAGT TTACAGATGCTAACTCTATATAAAGGAATGTGGAAAAACTCAGTTCTTAAGTTACAAGATTAAAAATTCACATTTGGTCTTTAAGAAACA ATTGACTGACATCTATGAATTTATTTTGTATCATGCTAGTAAACACGAAGTATTAATGTATGGGTATTTTCCCAGCTAGTTTTGCTTTCT TTTTCTGGAGCAAAACATTAAGTGATTGCAGAGTTTTTCAAGCAAGAGAAAAAGGTTTGCAAAAAAACCCAGGAAATGTTCCCTTTTTTC CCCACCATTCATCTTCATTAGATCAAATTCTGTGAAACTTGTCTGGTCTCTCAAAGGGAGCAGCCTCTGTAGTGTTAAATGGCTAATTAA AATAGGAAGATCTTTATAGCCAGAAACAACTTAGTCATCAAATAGCAAGTGAAACCAAAACGTCAGAGGGATTACTGTACTTGGAAGTAT GTTGTGTGTCCCAAATGTGAACGAAGTATTGTTAGAATTTATTAGATCAGCTTCTTTGGAGATCAAAGATTGGAAATCCTAGTCATAGAT ATTCACTGGACTGGCTTTGGACTGAAATGCTCCTTTGTAATTCTTTTCCTATTGTCTTTTCCTTCTAGTGTCCCAAAATATTTTCTTTAA AGTCAGCACAGTACTGTATATGAATCTTTAATGTGGTATCATATATGTCTACTTTTGTCTGATTCATCGATGTATTATATCTTTATAATT GAATATTTTAGCTCCGGGTCCTGTTGCCCCTTCAAGCAGTACATGCCAAATTATAAATAGGTGCTACTGGCCTTGAGCATATCACTGTGG GACAGTTCCCCAATTGTCAAGTGTTTAGATATGTAGACTATTGCCATTTGTTTTTTTGTTTTGGTTTTGCTTTGTGTCTGAAGCTGAATT GATTTCTTTTTTTTGAATGTGAAAGTTGAATTTCAAACGTAGTCATTTCTTACAGATGGCCAAGACAGAAAATTGTGGCTAGGTTGACTG AGAACTGTTGTCTTCCATGTATTAACACAATTAAGCTTTTTATATTCCACTCTCTGTGCTGACCCTGGCTGAGGCATTTTGGGAGACAAG GACTCTGAATCTTCTGCTTCCATTAAAGAAGAACTGTGATATTCAACATTGGATTTCTGAGAATAAAGATAGGATGATTCCTTTGAACTT TGACTTACTTGTATAAAATGTCCAGCTAGGTTAGGTTTTTGCCATTTCCTATATACTTTGGGTAAAGCTACATTTGATGAGCAATGTGAA TGTTTCTGAGAATGTTCATTCCTGTTTTCTCTTAAGAGAATGTGCTGTGTACTAAATACAGGCCACATAGTGTCTGCCTGTTGAAGATCT GGAAACTGCCTCCCCAGATCTGTATTGTATTTGGTAGGTAAGGGGGTCAGTTTCTTTTTCTCATTGTGTGTTGATAATCTACACACCATC TGTTGGAACCAGGGTGTTATTATGGGGAACTCCTCCTGTGTACTAGGAGGAGGACCTTAGGGAGACCAAGAGGAGAGAAGCATTTCCTTT GATGAAGTCACATCCTGTCTATGAGCCCACTAATGCTGTAACATTGGCCTGAAAGAGAGTGTTCTTTAAAAGCCTTTCTCGGCTGTTAGT ATAAAAACATGATGGTATCAGCTCTTAGCATGTTTGCTTGACCCTTATGGAAGGTATAAATCCACAGAACTTCCTTCCCAGAGAACTGGG AAATTGTCCTAGAAATAAACCTTGTACAGTTGAGTGGACATGGATAAGCAACAATTTGTTACTTTGCAGGATTTGTTCCTTGGTAATTGT TTGGTGTGTCATCCTGTAAATATTCATGATAGTCTGTTTATATCCTTTTGTATATCGTTGATACTGGATTGGGTAGAAAAATAAATTGGC >6336_6336_3_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000370622_NDC1_chr1_54275419_ENST00000371429_length(amino acids)=429AA_BP= MNLHIDEQVHRPLDTVSGLLNLSLLYHVWLCGVFLLTTWYVSWILFKIYATEAHVFPVQPPFAEGSDECLPKVLNSNPPPIIKYLALQDL MLLSQYSPSRRQEVFSLSQPGGHPHNWTAISRECLNLLNGMTQKLILYQEAAATNGRVSSSYPVEPKKLNSPEETAFQTPKSSQMPRPSV PPLVKTSLFSSKLSTPDVVSPFGTPFGSSVMNRMAGIFDVNTCYGSPQSPQLIRRGPRLWTSASDQQMTEFSNPSPSTSISAEGKTMRQP SVIYSWIQNKREQIKNFLSKRVLIMYFFSKHPEASIQAVFSDAQMHIWALEGLSHLVAASFTEDRFGVVQTTLPAILNTLLTLQEAVDKY -------------------------------------------------------------- >6336_6336_4_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000370622_NDC1_chr1_54275419_ENST00000540001_length(transcript)=4417nt_BP=698nt GCCCTGACCCTGCCACTTGTGTGAAGTCAGGATCTCCTTTCCCAGGCCTCAGTTGAGTCATCTGTAAAATGAGGAGACTAGAGTAGGGGT TGGGTAATGTCTAATGGTTGTAATGTCTGTTTTTAACTTGCCCATTTCCATCAGTTTCCGCTAGGCAAAGCTTTGCATATTTAGCTGCTC AGTTGGAACTAGTAGGAAGACCAAAGAGGATTTTGATATTTGATCCTGATGACCTTTATTCAGGGGTCAATTTCTCCAAGGTACTGAGTA CTCTTTTAGCTGTCAACAAAGCAACAGAAGATCAGCTATCAGAAAGACCATGTGGACGTTCCTCTTCTCTTAGTGCTGCTAATACTTCTC AGACAAACCCACAGGGAGCAGTTTCTAGCACAGTTTCAGGGCTGCAAAGGCAGTCAAAGACAGTGGAGATGACGGAAAATGGAAGTCATC AGTTGATAGTAAAAGCAAGATTCAACTTTAAGCAGACTAATGAGGATGAACTGTCAGTTTGTAAGGGGGACATCATTTACGTCACACGAG TTGAAGAAGGAGGCTGGTGGGAAGGCACATTAAATGGGAGAACAGGCTGGTTCCCCAGTAATTATGTCCGTGAAATTAAATCCAGTGAGA GACCTCTCTCCCCAAAAGCCGTCAAAGGATTTGAAACTGCTCCACTTACCAAGAATTATTATACTGTGGCTATATTCCCAAAGCTTGGAT TAGCACTGCTATGAACCTTCACATAGATGAGCAGGTTCATAGGCCACTTGACACAGTGAGTGGCCTCTTAAATCTCTCGTTACTCTACCA TGTCTGGCTGTGTGGTGTCTTTCTCCTGACGACTTGGTATGTCTCATGGATACTCTTCAAAATCTATGCCACAGAGGCTCATGTGTTTCC TGTTCAACCACCATTTGCAGAAGGGTCAGATGAGTGCCTTCCAAAAGTGTTAAATAGCAATCCTCCCCCCATCATAAAGTATTTAGCCTT GCAGGACCTGATGTTGCTTTCTCAATATTCTCCTTCACGAAGACAAGAAGTTTTCAGCCTCAGCCAACCAGGTGGACATCCCCACAATTG GACAGCCATTTCAAGGGAGTGTTTGAATCTTTTAAATGGTATGACTCAGAAACTGATTCTCTATCAAGAAGCTGCTGCTACGAATGGGAG AGTGTCTTCATCTTACCCAGTGGAACCTAAGAAATTAAATTCTCCAGAAGAAACTGCTTTTCAGACACCAAAATCTAGCCAGATGCCTCG GCCTTCAGTGCCACCATTAGTTAAAACATCACTGTTTTCTTCAAAATTATCTACACCTGATGTTGTGAGCCCATTTGGGACCCCATTTGG CTCTAGTGTAATGAATCGGATGGCTGGAATTTTTGATGTAAACACCTGCTATGGGTCACCGCAAAGTCCTCAGCTAATAAGAAGGGGGCC AAGATTGTGGACATCAGCTTCTGATCAGCAAATGACTGAATTTTCTAATCCTTCTCCATCTACCTCTATTAGTGCTGAGGCACCCAGAGG CCTCCATTCAGGCTGTTTTTTCAGATGCCCAAATGCATATTTGGGCATTAGAAGGTCTGTCGCACTTAGTAGCAGCATCATTTACAGAGG ATAGATTTGGAGTTGTCCAGACGACACTACCAGCTATCCTTAATACTTTGTTGACACTGCAAGAGGCAGTCGACAAGTACTTTAAGCTTC CTCATGCTTCCAGTAAACCACCCCGGATTTCAGGAAGCCTTGTGGACACTTCATATAAAACATTAAGATTTGCATTCAGAGCATCACTGA AAACTGCCATCTATCGAATAACTACTACATTTGGTGAACATCTGAATGCTGTGCAAGCATCTGCAGAACATCAGAAAAGACTTCAACAGT TCTTGGAGTTCAAAGAATAGTTAAGTAATATAAACTGTGTTCATTACACTGCTGATACAACTACAGATGGGACAGTAAATGTTCAGCATT CTTGGATCAGAAGAAAACGGACTAATTAGATGCTTCCTTTGTCGTGGTGGTTGCTTTGAAAACTATACTTTAATGGGAGAAATCATGGAA AGAAATTCTCAACAGAATAACTGAAAACTGCCTTTTCTGTACCGATTGCTTTTTGTGTGTGTGGTATAATAAAATCTTTATTCAATTTTA CAGAAGCATTGATGGCAGTCGAAATGTCTCTAGCTCATATAACTTAATAGTAATAACTAAAAAACTTTTAGAATTTACTTTTGAAAGGAG GGAAGCCAGTTCTGAAATGAGTATAGGTTGATTTCATAGTCTTCTTAATTAAGAGTTTAGCTCTTTGTAAACTCAAAATACATAAACTTT TTAAGTGTAGTTTCATTTACTGAAGGATAAAAATGGTAACAGTGCAGCAATATTCACAAAAAATATTGTCTAACGGACATATTTTGTTAA TCTGTTAGGTTGGGTTTTTGTTTCCAGGGACAAATTAAATTTGTATGATTACCCAAAAAAGGGTCTCAGTTTACAGATGCTAACTCTATA TAAAGGAATGTGGAAAAACTCAGTTCTTAAGTTACAAGATTAAAAATTCACATTTGGTCTTTAAGAAACAATTGACTGACATCTATGAAT TTATTTTGTATCATGCTAGTAAACACGAAGTATTAATGTATGGGTATTTTCCCAGCTAGTTTTGCTTTCTTTTTCTGGAGCAAAACATTA AGTGATTGCAGAGTTTTTCAAGCAAGAGAAAAAGGTTTGCAAAAAAACCCAGGAAATGTTCCCTTTTTTCCCCACCATTCATCTTCATTA GATCAAATTCTGTGAAACTTGTCTGGTCTCTCAAAGGGAGCAGCCTCTGTAGTGTTAAATGGCTAATTAAAATAGGAAGATCTTTATAGC CAGAAACAACTTAGTCATCAAATAGCAAGTGAAACCAAAACGTCAGAGGGATTACTGTACTTGGAAGTATGTTGTGTGTCCCAAATGTGA ACGAAGTATTGTTAGAATTTATTAGATCAGCTTCTTTGGAGATCAAAGATTGGAAATCCTAGTCATAGATATTCACTGGACTGGCTTTGG ACTGAAATGCTCCTTTGTAATTCTTTTCCTATTGTCTTTTCCTTCTAGTGTCCCAAAATATTTTCTTTAAAGTCAGCACAGTACTGTATA TGAATCTTTAATGTGGTATCATATATGTCTACTTTTGTCTGATTCATCGATGTATTATATCTTTATAATTGAATATTTTAGCTCCGGGTC CTGTTGCCCCTTCAAGCAGTACATGCCAAATTATAAATAGGTGCTACTGGCCTTGAGCATATCACTGTGGGACAGTTCCCCAATTGTCAA GTGTTTAGATATGTAGACTATTGCCATTTGTTTTTTTGTTTTGGTTTTGCTTTGTGTCTGAAGCTGAATTGATTTCTTTTTTTTGAATGT GAAAGTTGAATTTCAAACGTAGTCATTTCTTACAGATGGCCAAGACAGAAAATTGTGGCTAGGTTGACTGAGAACTGTTGTCTTCCATGT ATTAACACAATTAAGCTTTTTATATTCCACTCTCTGTGCTGACCCTGGCTGAGGCATTTTGGGAGACAAGGACTCTGAATCTTCTGCTTC CATTAAAGAAGAACTGTGATATTCAACATTGGATTTCTGAGAATAAAGATAGGATGATTCCTTTGAACTTTGACTTACTTGTATAAAATG TCCAGCTAGGTTAGGTTTTTGCCATTTCCTATATACTTTGGGTAAAGCTACATTTGATGAGCAATGTGAATGTTTCTGAGAATGTTCATT CCTGTTTTCTCTTAAGAGAATGTGCTGTGTACTAAATACAGGCCACATAGTGTCTGCCTGTTGAAGATCTGGAAACTGCCTCCCCAGATC TGTATTGTATTTGGTAGGTAAGGGGGTCAGTTTCTTTTTCTCATTGTGTGTTGATAATCTACACACCATCTGTTGGAACCAGGGTGTTAT TATGGGGAACTCCTCCTGTGTACTAGGAGGAGGACCTTAGGGAGACCAAGAGGAGAGAAGCATTTCCTTTGATGAAGTCACATCCTGTCT ATGAGCCCACTAATGCTGTAACATTGGCCTGAAAGAGAGTGTTCTTTAAAAGCCTTTCTCGGCTGTTAGTATAAAAACATGATGGTATCA GCTCTTAGCATGTTTGCTTGACCCTTATGGAAGGTATAAATCCACAGAACTTCCTTCCCAGAGAACTGGGAAATTGTCCTAGAAATAAAC CTTGTACAGTTGAGTGGACATGGATAAGCAACAATTTGTTACTTTGCAGGATTTGTTCCTTGGTAATTGTTTGGTGTGTCATCCTGTAAA TATTCATGATAGTCTGTTTATATCCTTTTGTATATCGTTGATACTGGATTGGGTAGAAAAATAAATTGGCAATTTAAAAAAATGGAACAG >6336_6336_4_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000370622_NDC1_chr1_54275419_ENST00000540001_length(amino acids)=297AA_BP= MNLHIDEQVHRPLDTVSGLLNLSLLYHVWLCGVFLLTTWYVSWILFKIYATEAHVFPVQPPFAEGSDECLPKVLNSNPPPIIKYLALQDL MLLSQYSPSRRQEVFSLSQPGGHPHNWTAISRECLNLLNGMTQKLILYQEAAATNGRVSSSYPVEPKKLNSPEETAFQTPKSSQMPRPSV PPLVKTSLFSSKLSTPDVVSPFGTPFGSSVMNRMAGIFDVNTCYGSPQSPQLIRRGPRLWTSASDQQMTEFSNPSPSTSISAEAPRGLHS -------------------------------------------------------------- >6336_6336_5_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000535227_NDC1_chr1_54275419_ENST00000371429_length(transcript)=4645nt_BP=813nt AAAGTTGCAGCCGCCCCTCCCCGCTGGGGCGAGCCTAGCCCAGCTCTCCAGTTTCGCCCTGGTGGCGGCCGCGCTCAGGGCAGGGTCCCA GCTCCGGCTGGGTTGATCTGTTCCCGCAGCCTTGGCACAGGCTTGCCCGCCCGCTCGCCGGCCCCGTGACTCGGGAGGGCGAACGGCTTC CAGGAGGCGGCGGCGGCGCGGCTGGAGTGAGGGAGCAGCTGGAGGACAGGCGGGCAGCGGCCGAGCCAGATATTTGATCCTGATGACCTT TATTCAGGGGTCAATTTCTCCAAGGTACTGAGTACTCTTTTAGCTGTCAACAAAGCAACAGAAGATCAGCTATCAGAAAGACCATGTGGA CGTTCCTCTTCTCTTAGTGCTGCTAATACTTCTCAGACAAACCCACAGGGAGCAGTTTCTAGCACAGTTTCAGGGCTGCAAAGGCAGTCA AAGACAGTGGAGATGACGGAAAATGGAAGTCATCAGTTGATAGTAAAAGCAAGATTCAACTTTAAGCAGACTAATGAGGATGAACTGTCA GTTTGTAAGGGGGACATCATTTACGTCACACGAGTTGAAGAAGGAGGCTGGTGGGAAGGCACATTAAATGGGAGAACAGGCTGGTTCCCC AGTAATTATGTCCGTGAAATTAAATCCAGTGATGGAGTTTCGCTCTTGTTGCCCGGGCTGGAGTGCAATGGCGCGATCTCAGCTCACCAC AACCTCTGCCTCCCAGGTTCAAAGAGACCTCTCTCCCCAAAAGCCGTCAAAGGATTTGAAACTGCTCCACTTACCAAGAATTATTATACT GTGGCTATATTCCCAAAGCTTGGATTAGCACTGCTATGAACCTTCACATAGATGAGCAGGTTCATAGGCCACTTGACACAGTGAGTGGCC TCTTAAATCTCTCGTTACTCTACCATGTCTGGCTGTGTGGTGTCTTTCTCCTGACGACTTGGTATGTCTCATGGATACTCTTCAAAATCT ATGCCACAGAGGCTCATGTGTTTCCTGTTCAACCACCATTTGCAGAAGGGTCAGATGAGTGCCTTCCAAAAGTGTTAAATAGCAATCCTC CCCCCATCATAAAGTATTTAGCCTTGCAGGACCTGATGTTGCTTTCTCAATATTCTCCTTCACGAAGACAAGAAGTTTTCAGCCTCAGCC AACCAGGTGGACATCCCCACAATTGGACAGCCATTTCAAGGGAGTGTTTGAATCTTTTAAATGGTATGACTCAGAAACTGATTCTCTATC AAGAAGCTGCTGCTACGAATGGGAGAGTGTCTTCATCTTACCCAGTGGAACCTAAGAAATTAAATTCTCCAGAAGAAACTGCTTTTCAGA CACCAAAATCTAGCCAGATGCCTCGGCCTTCAGTGCCACCATTAGTTAAAACATCACTGTTTTCTTCAAAATTATCTACACCTGATGTTG TGAGCCCATTTGGGACCCCATTTGGCTCTAGTGTAATGAATCGGATGGCTGGAATTTTTGATGTAAACACCTGCTATGGGTCACCGCAAA GTCCTCAGCTAATAAGAAGGGGGCCAAGATTGTGGACATCAGCTTCTGATCAGCAAATGACTGAATTTTCTAATCCTTCTCCATCTACCT CTATTAGTGCTGAGGGTAAGACAATGAGACAACCCAGTGTGATTTATTCATGGATTCAGAATAAACGTGAACAGATTAAGAATTTCTTGT CAAAACGGGTGCTGATAATGTATTTTTTCAGTAAGCACCCAGAGGCCTCCATTCAGGCTGTTTTTTCAGATGCCCAAATGCATATTTGGG CATTAGAAGGTCTGTCGCACTTAGTAGCAGCATCATTTACAGAGGATAGATTTGGAGTTGTCCAGACGACACTACCAGCTATCCTTAATA CTTTGTTGACACTGCAAGAGGCAGTCGACAAGTACTTTAAGCTTCCTCATGCTTCCAGTAAACCACCCCGGATTTCAGGAAGCCTTGTGG ACACTTCATATAAAACATTAAGATTTGCATTCAGAGCATCACTGAAAACTGCCATCTATCGAATAACTACTACATTTGGTGAACATCTGA ATGCTGTGCAAGCATCTGCAGAACATCAGAAAAGACTTCAACAGTTCTTGGAGTTCAAAGAATAGTTAAGTAATATAAACTGTGTTCATT ACACTGCTGATACAACTACAGATGGGACAGTAAATGTTCAGCATTCTTGGATCAGAAGAAAACGGACTAATTAGATGCTTCCTTTGTCGT GGTGGTTGCTTTGAAAACTATACTTTAATGGGAGAAATCATGGAAAGAAATTCTCAACAGAATAACTGAAAACTGCCTTTTCTGTACCGA TTGCTTTTTGTGTGTGTGGTATAATAAAATCTTTATTCAATTTTACAGAAGCATTGATGGCAGTCGAAATGTCTCTAGCTCATATAACTT AATAGTAATAACTAAAAAACTTTTAGAATTTACTTTTGAAAGGAGGGAAGCCAGTTCTGAAATGAGTATAGGTTGATTTCATAGTCTTCT TAATTAAGAGTTTAGCTCTTTGTAAACTCAAAATACATAAACTTTTTAAGTGTAGTTTCATTTACTGAAGGATAAAAATGGTAACAGTGC AGCAATATTCACAAAAAATATTGTCTAACGGACATATTTTGTTAATCTGTTAGGTTGGGTTTTTGTTTCCAGGGACAAATTAAATTTGTA TGATTACCCAAAAAAGGGTCTCAGTTTACAGATGCTAACTCTATATAAAGGAATGTGGAAAAACTCAGTTCTTAAGTTACAAGATTAAAA ATTCACATTTGGTCTTTAAGAAACAATTGACTGACATCTATGAATTTATTTTGTATCATGCTAGTAAACACGAAGTATTAATGTATGGGT ATTTTCCCAGCTAGTTTTGCTTTCTTTTTCTGGAGCAAAACATTAAGTGATTGCAGAGTTTTTCAAGCAAGAGAAAAAGGTTTGCAAAAA AACCCAGGAAATGTTCCCTTTTTTCCCCACCATTCATCTTCATTAGATCAAATTCTGTGAAACTTGTCTGGTCTCTCAAAGGGAGCAGCC TCTGTAGTGTTAAATGGCTAATTAAAATAGGAAGATCTTTATAGCCAGAAACAACTTAGTCATCAAATAGCAAGTGAAACCAAAACGTCA GAGGGATTACTGTACTTGGAAGTATGTTGTGTGTCCCAAATGTGAACGAAGTATTGTTAGAATTTATTAGATCAGCTTCTTTGGAGATCA AAGATTGGAAATCCTAGTCATAGATATTCACTGGACTGGCTTTGGACTGAAATGCTCCTTTGTAATTCTTTTCCTATTGTCTTTTCCTTC TAGTGTCCCAAAATATTTTCTTTAAAGTCAGCACAGTACTGTATATGAATCTTTAATGTGGTATCATATATGTCTACTTTTGTCTGATTC ATCGATGTATTATATCTTTATAATTGAATATTTTAGCTCCGGGTCCTGTTGCCCCTTCAAGCAGTACATGCCAAATTATAAATAGGTGCT ACTGGCCTTGAGCATATCACTGTGGGACAGTTCCCCAATTGTCAAGTGTTTAGATATGTAGACTATTGCCATTTGTTTTTTTGTTTTGGT TTTGCTTTGTGTCTGAAGCTGAATTGATTTCTTTTTTTTGAATGTGAAAGTTGAATTTCAAACGTAGTCATTTCTTACAGATGGCCAAGA CAGAAAATTGTGGCTAGGTTGACTGAGAACTGTTGTCTTCCATGTATTAACACAATTAAGCTTTTTATATTCCACTCTCTGTGCTGACCC TGGCTGAGGCATTTTGGGAGACAAGGACTCTGAATCTTCTGCTTCCATTAAAGAAGAACTGTGATATTCAACATTGGATTTCTGAGAATA AAGATAGGATGATTCCTTTGAACTTTGACTTACTTGTATAAAATGTCCAGCTAGGTTAGGTTTTTGCCATTTCCTATATACTTTGGGTAA AGCTACATTTGATGAGCAATGTGAATGTTTCTGAGAATGTTCATTCCTGTTTTCTCTTAAGAGAATGTGCTGTGTACTAAATACAGGCCA CATAGTGTCTGCCTGTTGAAGATCTGGAAACTGCCTCCCCAGATCTGTATTGTATTTGGTAGGTAAGGGGGTCAGTTTCTTTTTCTCATT GTGTGTTGATAATCTACACACCATCTGTTGGAACCAGGGTGTTATTATGGGGAACTCCTCCTGTGTACTAGGAGGAGGACCTTAGGGAGA CCAAGAGGAGAGAAGCATTTCCTTTGATGAAGTCACATCCTGTCTATGAGCCCACTAATGCTGTAACATTGGCCTGAAAGAGAGTGTTCT TTAAAAGCCTTTCTCGGCTGTTAGTATAAAAACATGATGGTATCAGCTCTTAGCATGTTTGCTTGACCCTTATGGAAGGTATAAATCCAC AGAACTTCCTTCCCAGAGAACTGGGAAATTGTCCTAGAAATAAACCTTGTACAGTTGAGTGGACATGGATAAGCAACAATTTGTTACTTT GCAGGATTTGTTCCTTGGTAATTGTTTGGTGTGTCATCCTGTAAATATTCATGATAGTCTGTTTATATCCTTTTGTATATCGTTGATACT >6336_6336_5_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000535227_NDC1_chr1_54275419_ENST00000371429_length(amino acids)=429AA_BP= MNLHIDEQVHRPLDTVSGLLNLSLLYHVWLCGVFLLTTWYVSWILFKIYATEAHVFPVQPPFAEGSDECLPKVLNSNPPPIIKYLALQDL MLLSQYSPSRRQEVFSLSQPGGHPHNWTAISRECLNLLNGMTQKLILYQEAAATNGRVSSSYPVEPKKLNSPEETAFQTPKSSQMPRPSV PPLVKTSLFSSKLSTPDVVSPFGTPFGSSVMNRMAGIFDVNTCYGSPQSPQLIRRGPRLWTSASDQQMTEFSNPSPSTSISAEGKTMRQP SVIYSWIQNKREQIKNFLSKRVLIMYFFSKHPEASIQAVFSDAQMHIWALEGLSHLVAASFTEDRFGVVQTTLPAILNTLLTLQEAVDKY -------------------------------------------------------------- >6336_6336_6_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000535227_NDC1_chr1_54275419_ENST00000540001_length(transcript)=4532nt_BP=813nt AAAGTTGCAGCCGCCCCTCCCCGCTGGGGCGAGCCTAGCCCAGCTCTCCAGTTTCGCCCTGGTGGCGGCCGCGCTCAGGGCAGGGTCCCA GCTCCGGCTGGGTTGATCTGTTCCCGCAGCCTTGGCACAGGCTTGCCCGCCCGCTCGCCGGCCCCGTGACTCGGGAGGGCGAACGGCTTC CAGGAGGCGGCGGCGGCGCGGCTGGAGTGAGGGAGCAGCTGGAGGACAGGCGGGCAGCGGCCGAGCCAGATATTTGATCCTGATGACCTT TATTCAGGGGTCAATTTCTCCAAGGTACTGAGTACTCTTTTAGCTGTCAACAAAGCAACAGAAGATCAGCTATCAGAAAGACCATGTGGA CGTTCCTCTTCTCTTAGTGCTGCTAATACTTCTCAGACAAACCCACAGGGAGCAGTTTCTAGCACAGTTTCAGGGCTGCAAAGGCAGTCA AAGACAGTGGAGATGACGGAAAATGGAAGTCATCAGTTGATAGTAAAAGCAAGATTCAACTTTAAGCAGACTAATGAGGATGAACTGTCA GTTTGTAAGGGGGACATCATTTACGTCACACGAGTTGAAGAAGGAGGCTGGTGGGAAGGCACATTAAATGGGAGAACAGGCTGGTTCCCC AGTAATTATGTCCGTGAAATTAAATCCAGTGATGGAGTTTCGCTCTTGTTGCCCGGGCTGGAGTGCAATGGCGCGATCTCAGCTCACCAC AACCTCTGCCTCCCAGGTTCAAAGAGACCTCTCTCCCCAAAAGCCGTCAAAGGATTTGAAACTGCTCCACTTACCAAGAATTATTATACT GTGGCTATATTCCCAAAGCTTGGATTAGCACTGCTATGAACCTTCACATAGATGAGCAGGTTCATAGGCCACTTGACACAGTGAGTGGCC TCTTAAATCTCTCGTTACTCTACCATGTCTGGCTGTGTGGTGTCTTTCTCCTGACGACTTGGTATGTCTCATGGATACTCTTCAAAATCT ATGCCACAGAGGCTCATGTGTTTCCTGTTCAACCACCATTTGCAGAAGGGTCAGATGAGTGCCTTCCAAAAGTGTTAAATAGCAATCCTC CCCCCATCATAAAGTATTTAGCCTTGCAGGACCTGATGTTGCTTTCTCAATATTCTCCTTCACGAAGACAAGAAGTTTTCAGCCTCAGCC AACCAGGTGGACATCCCCACAATTGGACAGCCATTTCAAGGGAGTGTTTGAATCTTTTAAATGGTATGACTCAGAAACTGATTCTCTATC AAGAAGCTGCTGCTACGAATGGGAGAGTGTCTTCATCTTACCCAGTGGAACCTAAGAAATTAAATTCTCCAGAAGAAACTGCTTTTCAGA CACCAAAATCTAGCCAGATGCCTCGGCCTTCAGTGCCACCATTAGTTAAAACATCACTGTTTTCTTCAAAATTATCTACACCTGATGTTG TGAGCCCATTTGGGACCCCATTTGGCTCTAGTGTAATGAATCGGATGGCTGGAATTTTTGATGTAAACACCTGCTATGGGTCACCGCAAA GTCCTCAGCTAATAAGAAGGGGGCCAAGATTGTGGACATCAGCTTCTGATCAGCAAATGACTGAATTTTCTAATCCTTCTCCATCTACCT CTATTAGTGCTGAGGCACCCAGAGGCCTCCATTCAGGCTGTTTTTTCAGATGCCCAAATGCATATTTGGGCATTAGAAGGTCTGTCGCAC TTAGTAGCAGCATCATTTACAGAGGATAGATTTGGAGTTGTCCAGACGACACTACCAGCTATCCTTAATACTTTGTTGACACTGCAAGAG GCAGTCGACAAGTACTTTAAGCTTCCTCATGCTTCCAGTAAACCACCCCGGATTTCAGGAAGCCTTGTGGACACTTCATATAAAACATTA AGATTTGCATTCAGAGCATCACTGAAAACTGCCATCTATCGAATAACTACTACATTTGGTGAACATCTGAATGCTGTGCAAGCATCTGCA GAACATCAGAAAAGACTTCAACAGTTCTTGGAGTTCAAAGAATAGTTAAGTAATATAAACTGTGTTCATTACACTGCTGATACAACTACA GATGGGACAGTAAATGTTCAGCATTCTTGGATCAGAAGAAAACGGACTAATTAGATGCTTCCTTTGTCGTGGTGGTTGCTTTGAAAACTA TACTTTAATGGGAGAAATCATGGAAAGAAATTCTCAACAGAATAACTGAAAACTGCCTTTTCTGTACCGATTGCTTTTTGTGTGTGTGGT ATAATAAAATCTTTATTCAATTTTACAGAAGCATTGATGGCAGTCGAAATGTCTCTAGCTCATATAACTTAATAGTAATAACTAAAAAAC TTTTAGAATTTACTTTTGAAAGGAGGGAAGCCAGTTCTGAAATGAGTATAGGTTGATTTCATAGTCTTCTTAATTAAGAGTTTAGCTCTT TGTAAACTCAAAATACATAAACTTTTTAAGTGTAGTTTCATTTACTGAAGGATAAAAATGGTAACAGTGCAGCAATATTCACAAAAAATA TTGTCTAACGGACATATTTTGTTAATCTGTTAGGTTGGGTTTTTGTTTCCAGGGACAAATTAAATTTGTATGATTACCCAAAAAAGGGTC TCAGTTTACAGATGCTAACTCTATATAAAGGAATGTGGAAAAACTCAGTTCTTAAGTTACAAGATTAAAAATTCACATTTGGTCTTTAAG AAACAATTGACTGACATCTATGAATTTATTTTGTATCATGCTAGTAAACACGAAGTATTAATGTATGGGTATTTTCCCAGCTAGTTTTGC TTTCTTTTTCTGGAGCAAAACATTAAGTGATTGCAGAGTTTTTCAAGCAAGAGAAAAAGGTTTGCAAAAAAACCCAGGAAATGTTCCCTT TTTTCCCCACCATTCATCTTCATTAGATCAAATTCTGTGAAACTTGTCTGGTCTCTCAAAGGGAGCAGCCTCTGTAGTGTTAAATGGCTA ATTAAAATAGGAAGATCTTTATAGCCAGAAACAACTTAGTCATCAAATAGCAAGTGAAACCAAAACGTCAGAGGGATTACTGTACTTGGA AGTATGTTGTGTGTCCCAAATGTGAACGAAGTATTGTTAGAATTTATTAGATCAGCTTCTTTGGAGATCAAAGATTGGAAATCCTAGTCA TAGATATTCACTGGACTGGCTTTGGACTGAAATGCTCCTTTGTAATTCTTTTCCTATTGTCTTTTCCTTCTAGTGTCCCAAAATATTTTC TTTAAAGTCAGCACAGTACTGTATATGAATCTTTAATGTGGTATCATATATGTCTACTTTTGTCTGATTCATCGATGTATTATATCTTTA TAATTGAATATTTTAGCTCCGGGTCCTGTTGCCCCTTCAAGCAGTACATGCCAAATTATAAATAGGTGCTACTGGCCTTGAGCATATCAC TGTGGGACAGTTCCCCAATTGTCAAGTGTTTAGATATGTAGACTATTGCCATTTGTTTTTTTGTTTTGGTTTTGCTTTGTGTCTGAAGCT GAATTGATTTCTTTTTTTTGAATGTGAAAGTTGAATTTCAAACGTAGTCATTTCTTACAGATGGCCAAGACAGAAAATTGTGGCTAGGTT GACTGAGAACTGTTGTCTTCCATGTATTAACACAATTAAGCTTTTTATATTCCACTCTCTGTGCTGACCCTGGCTGAGGCATTTTGGGAG ACAAGGACTCTGAATCTTCTGCTTCCATTAAAGAAGAACTGTGATATTCAACATTGGATTTCTGAGAATAAAGATAGGATGATTCCTTTG AACTTTGACTTACTTGTATAAAATGTCCAGCTAGGTTAGGTTTTTGCCATTTCCTATATACTTTGGGTAAAGCTACATTTGATGAGCAAT GTGAATGTTTCTGAGAATGTTCATTCCTGTTTTCTCTTAAGAGAATGTGCTGTGTACTAAATACAGGCCACATAGTGTCTGCCTGTTGAA GATCTGGAAACTGCCTCCCCAGATCTGTATTGTATTTGGTAGGTAAGGGGGTCAGTTTCTTTTTCTCATTGTGTGTTGATAATCTACACA CCATCTGTTGGAACCAGGGTGTTATTATGGGGAACTCCTCCTGTGTACTAGGAGGAGGACCTTAGGGAGACCAAGAGGAGAGAAGCATTT CCTTTGATGAAGTCACATCCTGTCTATGAGCCCACTAATGCTGTAACATTGGCCTGAAAGAGAGTGTTCTTTAAAAGCCTTTCTCGGCTG TTAGTATAAAAACATGATGGTATCAGCTCTTAGCATGTTTGCTTGACCCTTATGGAAGGTATAAATCCACAGAACTTCCTTCCCAGAGAA CTGGGAAATTGTCCTAGAAATAAACCTTGTACAGTTGAGTGGACATGGATAAGCAACAATTTGTTACTTTGCAGGATTTGTTCCTTGGTA ATTGTTTGGTGTGTCATCCTGTAAATATTCATGATAGTCTGTTTATATCCTTTTGTATATCGTTGATACTGGATTGGGTAGAAAAATAAA >6336_6336_6_ARHGEF6-NDC1_ARHGEF6_chrX_135814261_ENST00000535227_NDC1_chr1_54275419_ENST00000540001_length(amino acids)=297AA_BP= MNLHIDEQVHRPLDTVSGLLNLSLLYHVWLCGVFLLTTWYVSWILFKIYATEAHVFPVQPPFAEGSDECLPKVLNSNPPPIIKYLALQDL MLLSQYSPSRRQEVFSLSQPGGHPHNWTAISRECLNLLNGMTQKLILYQEAAATNGRVSSSYPVEPKKLNSPEETAFQTPKSSQMPRPSV PPLVKTSLFSSKLSTPDVVSPFGTPFGSSVMNRMAGIFDVNTCYGSPQSPQLIRRGPRLWTSASDQQMTEFSNPSPSTSISAEAPRGLHS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ARHGEF6-TMEM48 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ARHGEF6-TMEM48 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ARHGEF6-TMEM48 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ARHGEF6 | C3501611 | Mental Retardation, X-Linked Nonsyndromic | 4 | CLINGEN |
Hgene | ARHGEF6 | C1136249 | Mental Retardation, X-Linked | 1 | GENOMICS_ENGLAND |
Hgene | ARHGEF6 | C1845526 | Mental Retardation, X-Linked 46 | 1 | GENOMICS_ENGLAND |
Hgene | ARHGEF6 | C2931498 | Mental Retardation, X-Linked 1 | 1 | ORPHANET |
Tgene | C0043094 | Weight Gain | 1 | CTD_human |