Home

Download

Statistics

Examples

About

Contact

	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:ROCK2_PPP2CA (FusionGDB2 ID:HG9475TG5515)

Fusion Gene Summary for ROCK2_PPP2CA

Fusion gene summary

Fusion gene information	Fusion gene name: ROCK2_PPP2CA
	Fusion gene ID: hg9475tg5515
		Hgene	Tgene
	Gene symbol	ROCK2	PPP2CA
	Gene ID	9475	5515
	Gene name	Rho associated coiled-coil containing protein kinase 2	protein phosphatase 2 catalytic subunit alpha
	Synonyms	ROCK-II	HJS3\|NEDLBA\|PP2Ac\|PP2CA\|PP2Calpha\|RP-C
	Cytomap	2p25.1	5q31.1
	Type of gene	protein-coding	protein-coding
	Description	rho-associated protein kinase 2p164 ROCK-2rho-associated, coiled-coil-containing protein kinase II	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoformPP2A-alphaprotein phosphatase 2, catalytic subunit, alpha isozymereplication protein C
	Modification date	20240403	20240411
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000315872, ENST00000401753, ENST00000462366,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 27 X 18 X 20=9720	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 8 X 7 X 14=784
	# samples	45	70
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(45/972010)=-4.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(70/78410)=-0.163498732282879 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ROCK2 [Title/Abstract] AND PPP2CA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ROCK2(11484121)-PPP2CA(133541822), # samples:2

Fusion gene breakpoints across ROCK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PPP2CA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Breakpoints for ROCK2_PPP2CA

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ROCK2	chr2	11484121	PPP2CA	chr5	133541822
ROCK2	chr2	11484122	PPP2CA	chr5	133541822
ROCK2	chr2	11343996	PPP2CA	chr5	134206131

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

Top

Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for ROCK2_PPP2CA

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
ROCK2-PPP2CA	Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions M1		ROCK2 kinase domain couples to PP2A catalytic subunit alpha (PPP2CA), coordinating Rho-mediated cytoskeletal contraction with targeted serine/threonine dephosphorylation and PP2A regulation.		ROCK inhibitors; PP2A activators (SMAPs)		Carcinomas and solid tumors

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
ROCK2-PPP2CA	Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions M1		ROCK2 kinase domain couples to PP2A catalytic subunit alpha (PPP2CA), coordinating Rho-mediated cytoskeletal contraction with targeted serine/threonine dephosphorylation and PP2A regulation.	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 39739531; Title: IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth.	ROCK inhibitors; PP2A activators (SMAPs)		Carcinomas and solid tumors	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 36804120; Title: Luteolin directly binds to KDM4C and attenuates ovarian cancer stemness via epigenetic suppression of PPP2CA/YAP axis.; PMID: 36870954; Title: YTHDF2 exerts tumor-suppressor roles in gastric cancer via up-regulating PPP2CA independently of m6A modification.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ROCK2	GO:0006468	protein phosphorylation	18559669
Tgene	PPP2CA	GO:0035970	peptidyl-threonine dephosphorylation	30611118
Tgene	PPP2CA	GO:2000045	regulation of G1/S transition of mitotic cell cycle	25438055

Top

Fusion Genomic Features for ROCK2_PPP2CA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ROCK2	chr2	11484121	-	PPP2CA	chr5	133541822	-	8.40e-11	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

Top

Fusion Gene ORF Annotations for ROCK2_PPP2CA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000315872	ENST00000231504	ROCK2	chr2	11484121	-	PPP2CA	chr5	133541822	-
In-frame	ENST00000315872	ENST00000481195	ROCK2	chr2	11484121	-	PPP2CA	chr5	133541822	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000315872	ENST00000481195	ROCK2	chr2	11484121	PPP2CA	chr5	133541822	590	172

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000315872	ENST00000481195	ROCK2	chr2	11484121	PPP2CA	chr5	133541822	3.54e-03	9.96e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

Top

Fusion Protein Retained/Non-Retained Functional Features for ROCK2_PPP2CA

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

ROCK2_PPP2CA_chr2-11484121_chr5-133541822.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

O75116

1_27

47.0

1389.0

Region

Disordered

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

O75116

1053_1131

47.0

1389.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

O75116

429_1024

47.0

1389.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

O75116

1362_1376

47.0

1389.0

Compositional bias

Polar residues

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

O75116

1150_1349

47.0

1389.0

Domain

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

O75116

357_425

47.0

1389.0

Domain

AGC-kinase C-terminal

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

O75116

497_573

47.0

1389.0

Domain

REM-1

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

O75116

92_354

47.0

1389.0

Domain

Protein kinase

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

O75116

1345_1388

47.0

1389.0

Region

Disordered

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

O75116

979_1047

47.0

1389.0

Region

RHOA binding

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

O75116

1260_1315

47.0

1389.0

Zinc finger

Phorbol-ester/DAG-type

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Hgene

ROCK2

chr2:11484121

PPP2CA

chr5:133541822

ENST00000315872

O75116

373_420

47.0

1389.0

Region

NPM1

Hgene

ROCK2

chr2:11484121

PPP2CA

chr5:133541822

ENST00000315872

O75116

363_784

47.0

1389.0

Region

PPP1R12A

Top

Fusion Transcript Sequence for ROCK2_PPP2CA

In-frame Fusion Transcript Sequences.

>ROCK2_PPP2CA_ENST00000315872_ENST00000481195_11484121_133541822 length=4856nt 
 Breakpoint=590nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCGGGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTG
CGGGCACTCGCTGAGGACCAGCGGACCGGCGGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCGGGCCCCTGGGAGCAGCCCCCAGGCGGGGGA
CCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGGCCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGGAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGGCTAAAGAAA
TCCTGACAAAAGAATCCAACGTGCAAGAGGTTCGATGTCCAGTTACTGTCTGTGGAGATGTGCATGGGCAATTTCATGATCTCATGGAACTGTTTAGAATTGGTGGCAAATCACCAGATACAAATTACTTGTTTATGGGAGATTATGTTG
ACAGAGGATATTATTCAGTTGAAACAGTTACACTGCTTGTAGCTCTTAAGGTTCGTTACCGTGAACGCATCACCATTCTTCGAGGGAATCATGAGAGCAGACAGATCACACAAGTTTATGGTTTCTATGATGAATGTTTAAGAAAATATG
GAAATGCAAATGTTTGGAAATATTTTACAGATCTTTTTGACTATCTTCCTCTCACTGCCTTGGTGGATGGGCAGATCTTCTGTCTACATGGTGGTCTCTCGCCATCTATAGATACACTGGATCATATCAGAGCACTTGATCGCCTACAAG
AAGTTCCCCATGAGGGTCCAATGTGTGACTTGCTGTGGTCAGATCCAGATGACCGTGGTGGTTGGGGTATATCTCCTCGAGGAGCTGGTTACACCTTTGGGCAAGATATTTCTGAGACATTTAATCATGCCAATGGCCTCACGTTGGTGT
CTAGAGCTCACCAGCTAGTGATGGAGGGATATAACTGGTGCCATGACCGGAATGTAGTAACGATTTTCAGTGCTCCAAACTATTGTTATCGTTGTGGTAACCAAGCTGCAATCATGGAACTTGACGATACTCTAAAATACTCTTTCTTGC
AGTTTGACCCAGCACCTCGTAGAGGCGAGCCACATGTTACTCGTCGTACCCCAGACTACTTCCTGTAATGAAATTTTAAACTTGTACAGTATTGCCATGAACCATATATCGACCTAATGGAAATGGGAAGAGCAACAGTAACTCCAAAGT
GTCAGAAAATAGTTAACATTCAAAAAACTTGTTTTCACATGGACCAAAAGATGTGCCATATAAAAATACAAAGCCTCTTGTCATCAACAGCCGTGACCACTTTAGAATGAACCAGTTCATTGCATGCTGAAGCGACATTGTTGGTCAAGA
AACCAGTTTCTGGCATAGCGCTATTTGTAGTTACTTTTGCTTTCTCTGAGAGACTGCAGATAATAAGATGTAAACATTAACACCTCGTGAATACAATTTAACTTCCATTTAGCTATAGCTTTACTCAGCATGACTGTAGATAAGGATAGC
AGCAAACAATCATTGGAGCTTAATGAACATTTTTAAAAATAATTACCAAGGCCTCCCTTCTACTTGTGAGTTTTGAAATTGTTCTTTTTATTTTCAGGGATACCGTTTAATTTAATTATATGATTTGTCTGCACTCAGTTTATTCCCTAC
TCAAATCTCAGCCCCATGTTGTTCTTTGTTATTGTCAGAACCTGGTGAGTTGTTTTGAACAGAACTGTTTTTTCCCCTTCCTGTAAGACGATGTGACTGCACAAGAGCACTGCAGTGTTTTTCATAATAAACTTGTGAACTAAGAACTGA
GAAGGTCAAATTTTAATTGTATCAATGGGCAAGACTGGTGCTGTTTATTAAAAAAGTTAAATCAATTGAGTAAATTTTAGAATTTGTAGACTTGTAGGTAAAATAAAAATCAAGGGCACTACATAACCTCTCTGGTAACTCCTTGACATT
CTTCAGATTAACTTCAGGATTTATTTGTATTTCACATATTACAATTTGTCACATTGTTGGTGTGCACTTTGTGGGTTCTTCCTGCATATTAACTTGTTTGTAAGAAAGGAAATCTGTGCTGCTTCAGTAAGACTTAATTGTAAAACCATA
TAACTTGAGATTTAAGTCTTTGGGTTTTGTTTTAATAAAACAGCATGTTTTCAGGTAGAGCTTAAACTAAATGATGTGTTTACTTAGTGCAGTTTCTGGTTATGAATATTATATTGCTATGTGTATATTATATGGACTCTTTAAAATGAT
TGACAGATTGGCAAATTCTTAAATCTTTGTACATTGTTGAGTCATATGTTCTTAGAGTTAAATTTGTCTCAGATAAGAAAGTGTTAAAGCATTAGCCTGTGTCAAGTTCTTTGAGTGATACTAGTGAAACCAAATAGAAAACTATTGTTG
GATCATGATTTAGTCTTATGTACATTCACCCGAAGACAAAAATGGTACTTAAAGTGGCAGTGTTCAACATTTAATGAGTTTTTCCCCTTTTATCCTTCGAATAGGATTAGATGTTTAAAAAAAAGTTCTTCTGTGGGAACTAATATTTGA
TATTTTAACCTACCAGAGTAAACAGGAACACTTAATCATACTTGTGAGTGTAGTAAATAAAAGTTTTCTTGCTTTGTGCTGTGTTGAATCTGGAACCAACAGGGAAGTTATAGCATATCCCCTTTCTAAAATGCTTGAGGAACACATACA
TACCGAATGTCTTTTCTGATCTAATTGATAGTATTTTTAGTGGCTTGTGGAGTTAATTTTCCAAAGCAAAAGGCCATTAGGGTTTCTACATTTCATTTCATTTCATTCTTTTCTTTCACAAGAAATACATTCTCTGTGTGTCTTTTTGTT
GCTCTGTCACTCTATGCCCTTTCTCTCCGACTGAACAAATAGCTTATCCATGTGCAGTGGTTTTAATACCCAAACAATCTAGACACCAAGCAGCTATTTTTTCCGGTCCTGTGATATCAGAATTGACCAAGGAATACGTATATTGTAATT
GACACGTGGTGGTATCTTCCAGGTACAAATTCTCTAAATTTTGTGGTTAGCAGAATGGGACTTGTGATAAGAATAGCTTGGTTTTAGCATAACTAGGGTTTAAAATAATTGTTTAATTATAGAGACTGACCGGGCTTTGGCCATCTAAAC
TGGAAAGTGTTAGTACCCTACCTTCTTTTGAAAATGGCTATGGTAAGGAAAATGTGTTAGTAAATTATGTATTTTCTTGAAAAATACATAATTATGGTTGGATGGGAATCACTAAGTTGGGTGTTAACTGATGTCTCAATTAGTAACATT
AGGATTTTCATTAATAAACCTAAAAAGCTTTCCCTAAGAACAGGCCTGGCACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGACCAGGGTGGGTGGATCCCTTGAGGTCAGGAGTTGAAGAGCAGCCTGGCCAACATGGCAAAAC
CCCATCTCTACAAAAAATATGAAAATCAGCCGGGCTTGGTGGCATACCATAGTCCCAGCTACTTGGGAGGCTGAGGTGAGAGGATCGCCTGAGCCCAGGAGATGGAGGTTGCAGTGGGCTGAGATTGTGCCACTGTACTCCAGTCTGGGT
GACAGAGCCAGACCCTGTCTCAAAAATAAAGAGGATTCTGAGTTTGTATAGTGAGGGCTTGCAGAAATTTTGAAACTTATTTTGTAAGTTTACAATGAATTTGTACATGATGTGCTCATGTCTTGGGTTGAGTATCCTAGACATGATTTT
TTCATTTGCTGCATATTAAACATTTGTTGGTTGTAGTCGGTATTTCTTAAATAGAAGTTTGTCAATATTAGATTAGTTTCAAGAAGGACTTAGCTCAGGAAAAGGATAGTTATTTCTGTGGTTCTCAGCTTTGATGCCTACAGAGATTCT
GATTTAAATTGCTGGAGGAGGGCCCAGGCATACATTTTTTAAGTTTCCCAAGTGATTCTAATTTACATCTAGGGTTAAAAACAGCCAGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTGGGGAGGCCGGGGTGGGTGGATCACCTGA
TGTCAGGAGATCGAGACCAGCCTGGCCAGCGTGGTGAAACCCCATCTCTATTAAAAATACAAAACTGACCGGTGTGGTGGCAGGAGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACTCAGGAGGAGGAGGT
TACAGTGAGCCCAGATCGTGCCATTGCACTCCAGCCTGGGCAAAAAGAGCAAAACTCCATCTCAAAAAACAAAAACACCTCACTGCTGTTTCCTAAGTACATACTTAAGAAAATTGGGATACATGGTGGTGGTTCATGGATGTTGATAAG
GAATTAAAATGTACCGTGCGACTCTCTGTTTCAGTGGTGACTTTTACCTGTTTAGTATAAATATTCCTTTGCTTCCAACCATAAATGTGTTCTTAGAAATGGGCCTATAGTTTAGTAACCTATAGTTTGGTAATAGGCTTGTTTGTTTTC
AGATGGATTTTGGTTCTGTGAGCTAAAGCTATTTTGCATTAAAGCCTTCGTCCTCA

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

Top

Fusion Protein Sequence for ROCK2_PPP2CA

In-frame Fusion Protein Sequences.

>ROCK2_PPP2CA_ENST00000315872_ENST00000481195_11484121_133541822 length=172nt
MPRPPARSRGRRAFSPSAGAGSCRHRWTRTQAPRAQVPQPRGLAPPPNHQLRPGLHPGPPPASSSGFGSPRRSPAWGLLPGARPAQPGPARPGPAGSGGEQTASPPLSQIRAAGPLVLSECPQESSGGSREVAPPPPRPGPPRPLGPREA
EAQAWATTAAAGPLPWSPPAAL

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

Top

Personalized Fusion Protein Sequence for ROCK2_PPP2CA

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

Top

Fusion Gene Exprssed Samples for ROCK2_PPP2CA

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		BRCA	TCGA-BH-A0HL-01A	ROCK2	chr2	11484121	-	PPP2CA	chr5	133541822	-
ChimerDB		BRCA	TCGA-BH-A0HL	ROCK2	chr2	11484121	-	PPP2CA	chr5	133541822	-
WashU		BRCA	TCGA-BH-A0HL-01A	ROCK2	chr2	11484122	-	PPP2CA	chr5	133541822	-
cBioPortal	BRCA_TCGA_PAN_CAN_ATLAS_2018	BRCA	TCGA-BH-A0HL-01	ROCK2	chr2	11343996		PPP2CA	chr5	134206131

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

Top

Related Drugs for ROCK2_PPP2CA

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status