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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CD40-LAMC3 (FusionGDB2 ID:HG958TG10319) |
Fusion Gene Summary for CD40-LAMC3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CD40-LAMC3 | Fusion gene ID: hg958tg10319 | Hgene | Tgene | Gene symbol | CD40 | LAMC3 | Gene ID | 958 | 10319 |
| Gene name | CD40 molecule | laminin subunit gamma 3 | |
| Synonyms | Bp50|CDW40|TNFRSF5|p50 | OCCM | |
| Cytomap | ('CD40')('LAMC3') 20q13.12 | 9q34.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tumor necrosis factor receptor superfamily member 5B cell surface antigen CD40B cell-associated moleculeCD40 molecule, TNF receptor superfamily member 5CD40L receptor | laminin subunit gamma-3laminin, gamma 3laminin-12 subunit gammalaminin-14 subunit gammalaminin-15 subunit gamma | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | . | Q9Y6N6 | |
| Ensembl transtripts involved in fusion gene | ENST00000489304, ENST00000372276, ENST00000372285, | ||
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 6 X 5=180 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CD40 [Title/Abstract] AND LAMC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CD40(44751395)-LAMC3(133901672), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | CD40-LAMC3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CD40-LAMC3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CD40-LAMC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CD40-LAMC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CD40 | GO:0023035 | CD40 signaling pathway | 31331973 |
| Hgene | CD40 | GO:2000353 | positive regulation of endothelial cell apoptotic process | 12885753 |
| Fusion gene breakpoints across CD40 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across LAMC3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | GBM | TCGA-28-5215-01A | CD40 | chr20 | 44751395 | + | LAMC3 | chr9 | 133901672 | + |
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Fusion Gene ORF analysis for CD40-LAMC3 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000489304 | ENST00000361069 | CD40 | chr20 | 44751395 | + | LAMC3 | chr9 | 133901672 | + |
| 3UTR-3UTR | ENST00000489304 | ENST00000480883 | CD40 | chr20 | 44751395 | + | LAMC3 | chr9 | 133901672 | + |
| 5CDS-3UTR | ENST00000372276 | ENST00000480883 | CD40 | chr20 | 44751395 | + | LAMC3 | chr9 | 133901672 | + |
| 5CDS-3UTR | ENST00000372285 | ENST00000480883 | CD40 | chr20 | 44751395 | + | LAMC3 | chr9 | 133901672 | + |
| In-frame | ENST00000372276 | ENST00000361069 | CD40 | chr20 | 44751395 | + | LAMC3 | chr9 | 133901672 | + |
| In-frame | ENST00000372285 | ENST00000361069 | CD40 | chr20 | 44751395 | + | LAMC3 | chr9 | 133901672 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000372285 | CD40 | chr20 | 44751395 | + | ENST00000361069 | LAMC3 | chr9 | 133901672 | + | 6102 | 475 | 72 | 4829 | 1585 |
| ENST00000372276 | CD40 | chr20 | 44751395 | + | ENST00000361069 | LAMC3 | chr9 | 133901672 | + | 6058 | 431 | 28 | 4785 | 1585 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000372285 | ENST00000361069 | CD40 | chr20 | 44751395 | + | LAMC3 | chr9 | 133901672 | + | 0.007996205 | 0.99200374 |
| ENST00000372276 | ENST00000361069 | CD40 | chr20 | 44751395 | + | LAMC3 | chr9 | 133901672 | + | 0.007582798 | 0.9924172 |
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Fusion Genomic Features for CD40-LAMC3 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| CD40 | chr20 | 44751395 | + | LAMC3 | chr9 | 133901671 | + | 4.63E-05 | 0.99995375 |
| CD40 | chr20 | 44751395 | + | LAMC3 | chr9 | 133901671 | + | 4.63E-05 | 0.99995375 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CD40-LAMC3 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:44751395/chr9:133901672) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | LAMC3 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CD40 | chr20:44751395 | chr9:133901672 | ENST00000372276 | + | 4 | 8 | 25_60 | 134 | 505.0 | Repeat | Note=TNFR-Cys 1 |
| Hgene | CD40 | chr20:44751395 | chr9:133901672 | ENST00000372276 | + | 4 | 8 | 61_103 | 134 | 505.0 | Repeat | Note=TNFR-Cys 2 |
| Hgene | CD40 | chr20:44751395 | chr9:133901672 | ENST00000372285 | + | 4 | 9 | 25_60 | 134 | 278.0 | Repeat | Note=TNFR-Cys 1 |
| Hgene | CD40 | chr20:44751395 | chr9:133901672 | ENST00000372285 | + | 4 | 9 | 61_103 | 134 | 278.0 | Repeat | Note=TNFR-Cys 2 |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 1073_1134 | 124 | 1576.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 1201_1228 | 124 | 1576.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 1410_1492 | 124 | 1576.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 1523_1567 | 124 | 1576.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 271_326 | 124 | 1576.0 | Domain | Laminin EGF-like 1 | |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 327_382 | 124 | 1576.0 | Domain | Laminin EGF-like 2 | |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 383_429 | 124 | 1576.0 | Domain | Laminin EGF-like 3 | |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 430_479 | 124 | 1576.0 | Domain | Laminin EGF-like 4 | |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 480_489 | 124 | 1576.0 | Domain | Laminin EGF-like 5%3B first part | |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 499_672 | 124 | 1576.0 | Domain | Laminin IV type A | |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 673_706 | 124 | 1576.0 | Domain | Laminin EGF-like 5%3B second part | |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 707_754 | 124 | 1576.0 | Domain | Laminin EGF-like 6 | |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 755_809 | 124 | 1576.0 | Domain | Laminin EGF-like 7 | |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 810_865 | 124 | 1576.0 | Domain | Laminin EGF-like 8 | |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 866_916 | 124 | 1576.0 | Domain | Laminin EGF-like 9 | |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 917_964 | 124 | 1576.0 | Domain | Laminin EGF-like 10 | |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 965_1013 | 124 | 1576.0 | Domain | Laminin EGF-like 11 | |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 1059_1061 | 124 | 1576.0 | Motif | Cell attachment site | |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 1014_1575 | 124 | 1576.0 | Region | Note=Domain II and I |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CD40 | chr20:44751395 | chr9:133901672 | ENST00000372276 | + | 4 | 8 | 104_144 | 134 | 505.0 | Repeat | Note=TNFR-Cys 3 |
| Hgene | CD40 | chr20:44751395 | chr9:133901672 | ENST00000372276 | + | 4 | 8 | 145_187 | 134 | 505.0 | Repeat | Note=TNFR-Cys 4 |
| Hgene | CD40 | chr20:44751395 | chr9:133901672 | ENST00000372285 | + | 4 | 9 | 104_144 | 134 | 278.0 | Repeat | Note=TNFR-Cys 3 |
| Hgene | CD40 | chr20:44751395 | chr9:133901672 | ENST00000372285 | + | 4 | 9 | 145_187 | 134 | 278.0 | Repeat | Note=TNFR-Cys 4 |
| Hgene | CD40 | chr20:44751395 | chr9:133901672 | ENST00000372276 | + | 4 | 8 | 216_277 | 134 | 505.0 | Topological domain | Cytoplasmic |
| Hgene | CD40 | chr20:44751395 | chr9:133901672 | ENST00000372276 | + | 4 | 8 | 21_193 | 134 | 505.0 | Topological domain | Extracellular |
| Hgene | CD40 | chr20:44751395 | chr9:133901672 | ENST00000372285 | + | 4 | 9 | 216_277 | 134 | 278.0 | Topological domain | Cytoplasmic |
| Hgene | CD40 | chr20:44751395 | chr9:133901672 | ENST00000372285 | + | 4 | 9 | 21_193 | 134 | 278.0 | Topological domain | Extracellular |
| Hgene | CD40 | chr20:44751395 | chr9:133901672 | ENST00000372276 | + | 4 | 8 | 194_215 | 134 | 505.0 | Transmembrane | Helical |
| Hgene | CD40 | chr20:44751395 | chr9:133901672 | ENST00000372285 | + | 4 | 9 | 194_215 | 134 | 278.0 | Transmembrane | Helical |
| Tgene | LAMC3 | chr20:44751395 | chr9:133901672 | ENST00000361069 | 0 | 28 | 31_270 | 124 | 1576.0 | Domain | Laminin N-terminal |
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Fusion Gene Sequence for CD40-LAMC3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >14501_14501_1_CD40-LAMC3_CD40_chr20_44751395_ENST00000372276_LAMC3_chr9_133901672_ENST00000361069_length(transcript)=6058nt_BP=431nt TGGTCCTGCCGCCTGGTCTCACCTCGCTATGGTTCGTCTGCCTCTGCAGTGCGTCCTCTGGGGCTGCTTGCTGACCGCTGTCCATCCAGA ACCACCCACTGCATGCAGAGAAAAACAGTACCTAATAAACAGTCAGTGCTGTTCTTTGTGCCAGCCAGGACAGAAACTGGTGAGTGACTG CACAGAGTTCACTGAAACGGAATGCCTTCCTTGCGGTGAAAGCGAATTCCTAGACACCTGGAACAGAGAGACACACTGCCACCAGCACAA ATACTGCGACCCCAACCTAGGGCTTCGGGTCCAGCAGAAGGGCACCTCAGAAACAGACACCATCTGCACCTGTGAAGAAGGCTGGCACTG TACGAGTGAGGCCTGTGAGAGCTGTGTCCTGCACCGCTCATGCTCGCCCGGCTTTGGGGTCAAGCAGATTGGGAAGGCTTATGAGATCAC GTATGTGAGGCTGAAGTTCCACACCAGTCGCCCTGAGAGCTTTGCCATCTACAAGCGCAGCCGCGCCGACGGCCCATGGGAGCCCTACCA GTTCTACAGCGCCTCCTGCCAGAAGACCTACGGCCGGCCCGAGGGCCAGTACCTGCGCCCCGGCGAGGACGAGCGCGTGGCCTTCTGCAC CTCTGAGTTCAGCGACATCTCCCCGCTGAGTGGCGGCAACGTGGCCTTCTCCACCCTGGAGGGCCGGCCCAGCGCCTACAACTTCGAGGA GAGCCCTGGGCTGCAGGAGTGGGTCACCAGCACCGAACTCCTCATCTCTCTAGACCGGCTCAACACGTTTGGGGACGACATCTTCAAGGA CCCCAAGGTGCTCCAGTCCTACTATTATGCCGTGTCCGACTTCTCTGTGGGCGGCAGGTGCAAGTGCAACGGGCATGCCAGCGAGTGCGG CCCCGACGTGGCAGGCCAGTTGGCCTGCCGGTGCCAGCACAACACCACCGGCACAGACTGTGAGCGCTGCCTGCCCTTCTTCCAGGACCG CCCGTGGGCCCGGGGCACCGCCGAGGCTGCCCACGAGTGTCTGCCCTGCAACTGCAGTGGCCGCTCCGAGGAATGCACGTTTGATCGGGA GCTCTTCCGCAGCACAGGCCACGGCGGGCGCTGTCACCACTGCCGTGACCACACAGCTGGGCCACACTGTGAGCGCTGTCAGGAGAATTT CTATCACTGGGACCCGCGGATGCCATGCCAGCCCTGTGACTGCCAGTCGGCAGGCTCCCTACACCTCCAGTGCGATGACACAGGCACCTG CGCCTGCAAGCCCACGGTGACTGGCTGGAAGTGTGACCGCTGTCTGCCCGGGTTCCACTCGCTCAGTGAGGGAGGCTGCAGACCCTGCAC TTGCAATCCCGCTGGCAGCCTGGACACCTGTGACCCCCGCAGTGGGCGCTGCCCCTGCAAAGAGAATGTGGAAGGCAACCTATGTGACAG ATGTCGCCCGGGGACCTTTAACCTGCAGCCCCACAATCCAGCTGGCTGCAGCAGCTGTTTCTGCTATGGCCACTCCAAGGTGTGCGCGTC CACTGCCCAGTTCCAGGTGCATCACATCCTCAGCGATTTCCACCAGGGAGCCGAAGGCTGGTGGGCCAGAAGTGTGGGGGGCTCTGAGCA CCCCCCACAATGGAGCCCAAATGGGGTCCTCCTGAGCCCAGAAGACGAGGAGGAGCTCACAGCACCAGAGAAGTTCCTGGGAGACCAGCG GTTCAGCTATGGGCAGCCCCTCATACTGACCTTCCGGGTGCCCCCCGGGGACTCCCCACTCCCTGTACAGCTGAGGCTGGAAGGGACAGG CTTGGCCCTGTCCCTGAGGCACTCTAGCCTGTCTGGCCCCCAGGATGCCGGGCATCCCAGGGAGGTAGAGCTCAGGTTCCACCTGCAGGA GACCTCCGAGGACGTGGCCCCTCCACTGCCCCCCTTCCACTTCCAGCGGCTCCTCGCCAACCTGACCAGCCTCCGCCTCCGCGTCAGTCC CGGCCCCAGCCCTGCCGGTCCAGTGTTCCTGACTGAGGTCCGGCTCACATCCGCCCGGCCAGGGCTTTCCCCGCCAGCCTCCTGGGTGGA GATTTGTTCATGTCCCACTGGCTACACGGGCCAGTTCTGTGAATCCTGTGCTCCGGGATACAAGAGGGAGATGCCACAGGGGGGTCCCTA TGCCAGCTGTGTCCCCTGCACCTGTAACCAGCATGGCACCTGTGACCCCAACACAGGGATCTGTGTCTGCAGCCACCATACCGAGGGCCC ATCCTGTGAACGCTGTTTGCCAGGTTTCTATGGCAACCCTTTCGCGGGCCAAGCCGACGACTGCCAGCCCTGTCCCTGCCCTGGCCAGTC GGCCTGTACGACCATCCCAGAGAGCCGGGAGGTGGTGTGTACCCACTGCCCCCCGGGCCAGAGAGGGCGGCGCTGTGAGGTCTGTGATGA TGGCTTTTTTGGGGACCCGCTGGGGCTCTTTGGGCACCCCCAGCCCTGCCACCAGTGCCAGTGTAGCGGGAACGTGGACCCCAATGCCGT GGGCAACTGTGACCCCCTGTCTGGCCACTGCCTGCGCTGCCTGCACAACACCACGGGTGACCACTGTGAGCACTGTCAGGAAGGCTTCTA CGGGAGCGCCCTGGCCCCTCGACCCGCAGACAAATGCATGCCTTGCAGCTGTCACCCACAGGGCTCGGTCAGTGAGCAGATGCCCTGCGA CCCAGTGACAGGCCAATGCTCCTGCCTGCCTCATGTGACTGCACGGGACTGCAGCCGCTGCTACCCTGGCTTCTTCGACCTCCAGCCTGG GAGGGGCTGCCGGAGCTGCAAGTGTCACCCACTGGGCTCCCAGGAGGACCAGTGCCATCCCAAGACTGGACAGTGCACCTGCCGCCCAGG TGTCACAGGCCAGGCCTGTGACAGGTGCCAGCTGGGTTTCTTCGGCTTCTCCATCAAGGGCTGCCGGGCCTGCAGGTGCTCCCCACTGGG CGCTGCCTCGGCCCAGTGCCACGAGAACGGCACATGCGTGTGCAGGCCTGGCTTCGAGGGCTACAAATGTGACCGCTGCCACGACAACTT CTTCCTCACGGCAGACGGCACACACTGCCAGCAATGTCCGTCCTGCTACGCCCTGGTGAAGGAGGAGGCAGCCAAGCTGAAGGCCAGACT GACTTTGACGGAGGGGTGGCTCCAAGGGTCCGACTGTGGCAGTCCCTGGGGACCACTAGACATTCTGCTGGGAGAGGCCCCAAGGGGGGA CGTCTACCAGGGCCATCACCTGCTTCCAGGGGCTCGGGAAGCCTTCCTGGAGCAGATGATGAGCCTCGAGGGTGCTGTCAAGGCCGCCCG GGAGCAGCTGCAGAGGCTGAACAAGGGTGCCCGCTGTGCCCAGGCCGGATCCCAGAAGACCTGCACCCAGCTGGCAGACCTGGAGGCAGT GCTGGAGTCCTCGGAAGAGGAGATTCTGCATGCAGCTGCCATTCTCGCGTCTCTGGAGATTCCTCAGGAAGGTCCCAGTCAGCCGACCAA ATGGAGCCACCTGGCCACAGAGGCCCGTGCCCTCGCCAGGAGCCACAGAGACACCGCCACCAAGATCGCAGCCACTGCTTGGAGGGCCCT GCTCGCCTCCAACACCAGCTACGCGCTTCTCTGGAATCTGCTGGAGGGAAGGGTGGCCCTAGAGACCCAGCGGGACCTGGAGGACAGGTA CCAGGAGGTCCAGGCGGCCCAGAAAGCACTGAGGACGGCTGTGGCAGAGGTGCTGCCTGAAGCGGAAAGCGTGTTGGCCACCGTGCAGCA AGTTGGCGCAGATACAGCCCCGTACCTGGCCTTGCTGGCTTCCCCGGGAGCTCTGCCTCAGAAGTCCCGGGCTGAAGACCTGGGCCTGAA GGCGAAGGCCCTGGAGAAGACAGTTGCATCATGGCAGCACATGGCCACTGAGGCTGCCCGAACCCTCCAGACTGCTGCCCAGGCGACGCT ACGGCAAACAGAACCCCTCACAAAGCTGCACCAGGAGGCCAGAGCCGCCCTGACCCAGGCTTCCTCATCTGTCCAGGCTGCGACAGTGAC TGTCATGGGAGCCAGGACTCTGCTGGCTGATCTGGAAGGAATGAAGCTGCAGTTTCCCCGGCCCAAGGACCAGGCGGCATTGCAGAGGAA GGCAGACTCCGTCAGTGACAGACTCCTTGCAGACACGAGAAAGAAGACCAAGCAGGCGGAGAGGATGCTGGGAAACGCGGCCCCTCTTTC CTCCAGTGCCAAGAAGAAGGGCAGAGAAGCAGAGGTGTTGGCCAAGGACAGTGCCAAGCTTGCCAAGGCCTTGCTGAGGGAGCGGAAACA GGCGCACCGCCGTGCCAGCAGGCTCACCAGCCAGACGCAAGCCACGCTCCAACAGGCGTCCCAGCAGGTGCTGGCGTCTGAAGCACGCAG ACAGGAGCTGGAGGAAGCTGAGCGGGTGGGTGCTGGGCTGAGCGAGATGGAGCAGCAGATCCGGGAATCGCGTATCTCACTGGAGAAGGA CATCGAGACCTTGTCAGAGCTGCTTGCCAGGCTGGGGTCGCTGGACACCCATCAAGCCCCAGCCCAGGCCCTGAACGAGACTCAGTGGGC ACTAGAACGCCTGAGGCTGCAGCTGGGCTCCCCGGGGTCCTTGCAGAGGAAACTCAGTCTGCTGGAGCAGGAATCCCAGCAGCAGGAGCT GCAGATCCAGGGCTTCGAGAGTGACCTCGCCGAGATCCGCGCCGACAAACAGAACCTGGAGGCCATTCTGCACAGCCTGCCCGAGAACTG TGCCAGCTGGCAGTGAGGGCTGCCCAGATCCCCGGCACACACTCCCCCACCTGCTGTTTACATGACCCAGGGGGTGCACACTACCCCACA GGTGTGCCCATACAGACATTCCCCGGAGCCGGCTGCTGTGAACTCGCCCCCGTGTGGATAGTCACTCCCTGCCGATTCTGTCTGTGGCTT CTTCCCTGCCAGCAGGACTGAGTGTGCGTACCCAGTTCACCTGGACATGAGTGCACACTCTCACCCCTGCACATGCATAAACGGGCACAC CCCAGTGTCAATAACATACACACGTGAGGGTGCATGTCTGTGTGTATGACCCACACGTGTTCAAGTCTAATCCATCCAGTCAGCAGCTTA CGGTCCACACACATTACAGTCCACAGCTGTTGTGAGAGCCACCTGTGTGCTGGACACCCTCTGGATGTTGGGCAAGTTGTTACATGAGAT GCCCTGGGGTGCTACATCCACTCACTCCAGATAGCAGGGAGGTCTCAGCAGATCTGCAGAGATCAAGGGGGTCAGCAACAGCCAAAGCCC CTAGTCCCAGAGCTGGCTGCCCTCTGTTTCACAGCAGCTCCCTGACCTGTGTTGCTGCGTGCACTCCCTACAGCTCGACACAGCCAGGGG ACCAACAGGCCAAGAAATGCAAGATCCCGGGAGGGTTCTTAGCAGCAGAATCTGAGGCCCAGAGACCCTGAGGCCGTGGCCAGGCCTGCT AGTCTGGCTAGAGCAAGGCCCATTCCTGGCGGGGGTGTCATTGCCTTCACCGGACGCTTCCCTCTCAGGGTCCTGGGACTGCACCAGATG CCCTGAGGGAATGGCCCACCCTGGCCTGTACCCACTTCAGCCTGTGATCTATCCAAAGAGCCAGGCCCAAAAGCGCCTAGGTCAGGGTGC TCAGGCTACCAGGAGCACGCCTCTGTGCCCCCGGCAACCCAGTTGACCTTTAATTGACGCTTTCCAGACCAGCCCTGCGGCACCACTTGC CATGCGGGAGGCCACCAGGGTGTGCAAGCCTGGCTGCCATTCCAGTCTGTCCTGTCTGGGAATCGCCCTGTGGCCAGGCCCGCATGCTGG CCTCTGCCCAGGACTCCTCAGCATTTCCTCTTGGCATCCCTCCCCTCTCCCAGACCCTCTTCCAGCAGATGGCAAGGCCTCGGCATTGGG AAGTCAGGCACCTCTGCGGGCCCAGCCCCCTCCCGTGGCTCCCCTGACAGGGGCAGGGGTAGGGCAGCAGCACAGACCAATTCCGTTGAA >14501_14501_1_CD40-LAMC3_CD40_chr20_44751395_ENST00000372276_LAMC3_chr9_133901672_ENST00000361069_length(amino acids)=1585AA_BP=134 MVRLPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLR VQQKGTSETDTICTCEEGWHCTSEACESCVLHRSCSPGFGVKQIGKAYEITYVRLKFHTSRPESFAIYKRSRADGPWEPYQFYSASCQKT YGRPEGQYLRPGEDERVAFCTSEFSDISPLSGGNVAFSTLEGRPSAYNFEESPGLQEWVTSTELLISLDRLNTFGDDIFKDPKVLQSYYY AVSDFSVGGRCKCNGHASECGPDVAGQLACRCQHNTTGTDCERCLPFFQDRPWARGTAEAAHECLPCNCSGRSEECTFDRELFRSTGHGG RCHHCRDHTAGPHCERCQENFYHWDPRMPCQPCDCQSAGSLHLQCDDTGTCACKPTVTGWKCDRCLPGFHSLSEGGCRPCTCNPAGSLDT CDPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPAGCSSCFCYGHSKVCASTAQFQVHHILSDFHQGAEGWWARSVGGSEHPPQWSPNGV LLSPEDEEELTAPEKFLGDQRFSYGQPLILTFRVPPGDSPLPVQLRLEGTGLALSLRHSSLSGPQDAGHPREVELRFHLQETSEDVAPPL PPFHFQRLLANLTSLRLRVSPGPSPAGPVFLTEVRLTSARPGLSPPASWVEICSCPTGYTGQFCESCAPGYKREMPQGGPYASCVPCTCN QHGTCDPNTGICVCSHHTEGPSCERCLPGFYGNPFAGQADDCQPCPCPGQSACTTIPESREVVCTHCPPGQRGRRCEVCDDGFFGDPLGL FGHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHCEHCQEGFYGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCL PHVTARDCSRCYPGFFDLQPGRGCRSCKCHPLGSQEDQCHPKTGQCTCRPGVTGQACDRCQLGFFGFSIKGCRACRCSPLGAASAQCHEN GTCVCRPGFEGYKCDRCHDNFFLTADGTHCQQCPSCYALVKEEAAKLKARLTLTEGWLQGSDCGSPWGPLDILLGEAPRGDVYQGHHLLP GAREAFLEQMMSLEGAVKAAREQLQRLNKGARCAQAGSQKTCTQLADLEAVLESSEEEILHAAAILASLEIPQEGPSQPTKWSHLATEAR ALARSHRDTATKIAATAWRALLASNTSYALLWNLLEGRVALETQRDLEDRYQEVQAAQKALRTAVAEVLPEAESVLATVQQVGADTAPYL ALLASPGALPQKSRAEDLGLKAKALEKTVASWQHMATEAARTLQTAAQATLRQTEPLTKLHQEARAALTQASSSVQAATVTVMGARTLLA DLEGMKLQFPRPKDQAALQRKADSVSDRLLADTRKKTKQAERMLGNAAPLSSSAKKKGREAEVLAKDSAKLAKALLRERKQAHRRASRLT SQTQATLQQASQQVLASEARRQELEEAERVGAGLSEMEQQIRESRISLEKDIETLSELLARLGSLDTHQAPAQALNETQWALERLRLQLG -------------------------------------------------------------- >14501_14501_2_CD40-LAMC3_CD40_chr20_44751395_ENST00000372285_LAMC3_chr9_133901672_ENST00000361069_length(transcript)=6102nt_BP=475nt GGCTGGGGCAGGGGAGTCAGCAGAGGCCTCGCTCGGGCGCCCAGTGGTCCTGCCGCCTGGTCTCACCTCGCTATGGTTCGTCTGCCTCTG CAGTGCGTCCTCTGGGGCTGCTTGCTGACCGCTGTCCATCCAGAACCACCCACTGCATGCAGAGAAAAACAGTACCTAATAAACAGTCAG TGCTGTTCTTTGTGCCAGCCAGGACAGAAACTGGTGAGTGACTGCACAGAGTTCACTGAAACGGAATGCCTTCCTTGCGGTGAAAGCGAA TTCCTAGACACCTGGAACAGAGAGACACACTGCCACCAGCACAAATACTGCGACCCCAACCTAGGGCTTCGGGTCCAGCAGAAGGGCACC TCAGAAACAGACACCATCTGCACCTGTGAAGAAGGCTGGCACTGTACGAGTGAGGCCTGTGAGAGCTGTGTCCTGCACCGCTCATGCTCG CCCGGCTTTGGGGTCAAGCAGATTGGGAAGGCTTATGAGATCACGTATGTGAGGCTGAAGTTCCACACCAGTCGCCCTGAGAGCTTTGCC ATCTACAAGCGCAGCCGCGCCGACGGCCCATGGGAGCCCTACCAGTTCTACAGCGCCTCCTGCCAGAAGACCTACGGCCGGCCCGAGGGC CAGTACCTGCGCCCCGGCGAGGACGAGCGCGTGGCCTTCTGCACCTCTGAGTTCAGCGACATCTCCCCGCTGAGTGGCGGCAACGTGGCC TTCTCCACCCTGGAGGGCCGGCCCAGCGCCTACAACTTCGAGGAGAGCCCTGGGCTGCAGGAGTGGGTCACCAGCACCGAACTCCTCATC TCTCTAGACCGGCTCAACACGTTTGGGGACGACATCTTCAAGGACCCCAAGGTGCTCCAGTCCTACTATTATGCCGTGTCCGACTTCTCT GTGGGCGGCAGGTGCAAGTGCAACGGGCATGCCAGCGAGTGCGGCCCCGACGTGGCAGGCCAGTTGGCCTGCCGGTGCCAGCACAACACC ACCGGCACAGACTGTGAGCGCTGCCTGCCCTTCTTCCAGGACCGCCCGTGGGCCCGGGGCACCGCCGAGGCTGCCCACGAGTGTCTGCCC TGCAACTGCAGTGGCCGCTCCGAGGAATGCACGTTTGATCGGGAGCTCTTCCGCAGCACAGGCCACGGCGGGCGCTGTCACCACTGCCGT GACCACACAGCTGGGCCACACTGTGAGCGCTGTCAGGAGAATTTCTATCACTGGGACCCGCGGATGCCATGCCAGCCCTGTGACTGCCAG TCGGCAGGCTCCCTACACCTCCAGTGCGATGACACAGGCACCTGCGCCTGCAAGCCCACGGTGACTGGCTGGAAGTGTGACCGCTGTCTG CCCGGGTTCCACTCGCTCAGTGAGGGAGGCTGCAGACCCTGCACTTGCAATCCCGCTGGCAGCCTGGACACCTGTGACCCCCGCAGTGGG CGCTGCCCCTGCAAAGAGAATGTGGAAGGCAACCTATGTGACAGATGTCGCCCGGGGACCTTTAACCTGCAGCCCCACAATCCAGCTGGC TGCAGCAGCTGTTTCTGCTATGGCCACTCCAAGGTGTGCGCGTCCACTGCCCAGTTCCAGGTGCATCACATCCTCAGCGATTTCCACCAG GGAGCCGAAGGCTGGTGGGCCAGAAGTGTGGGGGGCTCTGAGCACCCCCCACAATGGAGCCCAAATGGGGTCCTCCTGAGCCCAGAAGAC GAGGAGGAGCTCACAGCACCAGAGAAGTTCCTGGGAGACCAGCGGTTCAGCTATGGGCAGCCCCTCATACTGACCTTCCGGGTGCCCCCC GGGGACTCCCCACTCCCTGTACAGCTGAGGCTGGAAGGGACAGGCTTGGCCCTGTCCCTGAGGCACTCTAGCCTGTCTGGCCCCCAGGAT GCCGGGCATCCCAGGGAGGTAGAGCTCAGGTTCCACCTGCAGGAGACCTCCGAGGACGTGGCCCCTCCACTGCCCCCCTTCCACTTCCAG CGGCTCCTCGCCAACCTGACCAGCCTCCGCCTCCGCGTCAGTCCCGGCCCCAGCCCTGCCGGTCCAGTGTTCCTGACTGAGGTCCGGCTC ACATCCGCCCGGCCAGGGCTTTCCCCGCCAGCCTCCTGGGTGGAGATTTGTTCATGTCCCACTGGCTACACGGGCCAGTTCTGTGAATCC TGTGCTCCGGGATACAAGAGGGAGATGCCACAGGGGGGTCCCTATGCCAGCTGTGTCCCCTGCACCTGTAACCAGCATGGCACCTGTGAC CCCAACACAGGGATCTGTGTCTGCAGCCACCATACCGAGGGCCCATCCTGTGAACGCTGTTTGCCAGGTTTCTATGGCAACCCTTTCGCG GGCCAAGCCGACGACTGCCAGCCCTGTCCCTGCCCTGGCCAGTCGGCCTGTACGACCATCCCAGAGAGCCGGGAGGTGGTGTGTACCCAC TGCCCCCCGGGCCAGAGAGGGCGGCGCTGTGAGGTCTGTGATGATGGCTTTTTTGGGGACCCGCTGGGGCTCTTTGGGCACCCCCAGCCC TGCCACCAGTGCCAGTGTAGCGGGAACGTGGACCCCAATGCCGTGGGCAACTGTGACCCCCTGTCTGGCCACTGCCTGCGCTGCCTGCAC AACACCACGGGTGACCACTGTGAGCACTGTCAGGAAGGCTTCTACGGGAGCGCCCTGGCCCCTCGACCCGCAGACAAATGCATGCCTTGC AGCTGTCACCCACAGGGCTCGGTCAGTGAGCAGATGCCCTGCGACCCAGTGACAGGCCAATGCTCCTGCCTGCCTCATGTGACTGCACGG GACTGCAGCCGCTGCTACCCTGGCTTCTTCGACCTCCAGCCTGGGAGGGGCTGCCGGAGCTGCAAGTGTCACCCACTGGGCTCCCAGGAG GACCAGTGCCATCCCAAGACTGGACAGTGCACCTGCCGCCCAGGTGTCACAGGCCAGGCCTGTGACAGGTGCCAGCTGGGTTTCTTCGGC TTCTCCATCAAGGGCTGCCGGGCCTGCAGGTGCTCCCCACTGGGCGCTGCCTCGGCCCAGTGCCACGAGAACGGCACATGCGTGTGCAGG CCTGGCTTCGAGGGCTACAAATGTGACCGCTGCCACGACAACTTCTTCCTCACGGCAGACGGCACACACTGCCAGCAATGTCCGTCCTGC TACGCCCTGGTGAAGGAGGAGGCAGCCAAGCTGAAGGCCAGACTGACTTTGACGGAGGGGTGGCTCCAAGGGTCCGACTGTGGCAGTCCC TGGGGACCACTAGACATTCTGCTGGGAGAGGCCCCAAGGGGGGACGTCTACCAGGGCCATCACCTGCTTCCAGGGGCTCGGGAAGCCTTC CTGGAGCAGATGATGAGCCTCGAGGGTGCTGTCAAGGCCGCCCGGGAGCAGCTGCAGAGGCTGAACAAGGGTGCCCGCTGTGCCCAGGCC GGATCCCAGAAGACCTGCACCCAGCTGGCAGACCTGGAGGCAGTGCTGGAGTCCTCGGAAGAGGAGATTCTGCATGCAGCTGCCATTCTC GCGTCTCTGGAGATTCCTCAGGAAGGTCCCAGTCAGCCGACCAAATGGAGCCACCTGGCCACAGAGGCCCGTGCCCTCGCCAGGAGCCAC AGAGACACCGCCACCAAGATCGCAGCCACTGCTTGGAGGGCCCTGCTCGCCTCCAACACCAGCTACGCGCTTCTCTGGAATCTGCTGGAG GGAAGGGTGGCCCTAGAGACCCAGCGGGACCTGGAGGACAGGTACCAGGAGGTCCAGGCGGCCCAGAAAGCACTGAGGACGGCTGTGGCA GAGGTGCTGCCTGAAGCGGAAAGCGTGTTGGCCACCGTGCAGCAAGTTGGCGCAGATACAGCCCCGTACCTGGCCTTGCTGGCTTCCCCG GGAGCTCTGCCTCAGAAGTCCCGGGCTGAAGACCTGGGCCTGAAGGCGAAGGCCCTGGAGAAGACAGTTGCATCATGGCAGCACATGGCC ACTGAGGCTGCCCGAACCCTCCAGACTGCTGCCCAGGCGACGCTACGGCAAACAGAACCCCTCACAAAGCTGCACCAGGAGGCCAGAGCC GCCCTGACCCAGGCTTCCTCATCTGTCCAGGCTGCGACAGTGACTGTCATGGGAGCCAGGACTCTGCTGGCTGATCTGGAAGGAATGAAG CTGCAGTTTCCCCGGCCCAAGGACCAGGCGGCATTGCAGAGGAAGGCAGACTCCGTCAGTGACAGACTCCTTGCAGACACGAGAAAGAAG ACCAAGCAGGCGGAGAGGATGCTGGGAAACGCGGCCCCTCTTTCCTCCAGTGCCAAGAAGAAGGGCAGAGAAGCAGAGGTGTTGGCCAAG GACAGTGCCAAGCTTGCCAAGGCCTTGCTGAGGGAGCGGAAACAGGCGCACCGCCGTGCCAGCAGGCTCACCAGCCAGACGCAAGCCACG CTCCAACAGGCGTCCCAGCAGGTGCTGGCGTCTGAAGCACGCAGACAGGAGCTGGAGGAAGCTGAGCGGGTGGGTGCTGGGCTGAGCGAG ATGGAGCAGCAGATCCGGGAATCGCGTATCTCACTGGAGAAGGACATCGAGACCTTGTCAGAGCTGCTTGCCAGGCTGGGGTCGCTGGAC ACCCATCAAGCCCCAGCCCAGGCCCTGAACGAGACTCAGTGGGCACTAGAACGCCTGAGGCTGCAGCTGGGCTCCCCGGGGTCCTTGCAG AGGAAACTCAGTCTGCTGGAGCAGGAATCCCAGCAGCAGGAGCTGCAGATCCAGGGCTTCGAGAGTGACCTCGCCGAGATCCGCGCCGAC AAACAGAACCTGGAGGCCATTCTGCACAGCCTGCCCGAGAACTGTGCCAGCTGGCAGTGAGGGCTGCCCAGATCCCCGGCACACACTCCC CCACCTGCTGTTTACATGACCCAGGGGGTGCACACTACCCCACAGGTGTGCCCATACAGACATTCCCCGGAGCCGGCTGCTGTGAACTCG CCCCCGTGTGGATAGTCACTCCCTGCCGATTCTGTCTGTGGCTTCTTCCCTGCCAGCAGGACTGAGTGTGCGTACCCAGTTCACCTGGAC ATGAGTGCACACTCTCACCCCTGCACATGCATAAACGGGCACACCCCAGTGTCAATAACATACACACGTGAGGGTGCATGTCTGTGTGTA TGACCCACACGTGTTCAAGTCTAATCCATCCAGTCAGCAGCTTACGGTCCACACACATTACAGTCCACAGCTGTTGTGAGAGCCACCTGT GTGCTGGACACCCTCTGGATGTTGGGCAAGTTGTTACATGAGATGCCCTGGGGTGCTACATCCACTCACTCCAGATAGCAGGGAGGTCTC AGCAGATCTGCAGAGATCAAGGGGGTCAGCAACAGCCAAAGCCCCTAGTCCCAGAGCTGGCTGCCCTCTGTTTCACAGCAGCTCCCTGAC CTGTGTTGCTGCGTGCACTCCCTACAGCTCGACACAGCCAGGGGACCAACAGGCCAAGAAATGCAAGATCCCGGGAGGGTTCTTAGCAGC AGAATCTGAGGCCCAGAGACCCTGAGGCCGTGGCCAGGCCTGCTAGTCTGGCTAGAGCAAGGCCCATTCCTGGCGGGGGTGTCATTGCCT TCACCGGACGCTTCCCTCTCAGGGTCCTGGGACTGCACCAGATGCCCTGAGGGAATGGCCCACCCTGGCCTGTACCCACTTCAGCCTGTG ATCTATCCAAAGAGCCAGGCCCAAAAGCGCCTAGGTCAGGGTGCTCAGGCTACCAGGAGCACGCCTCTGTGCCCCCGGCAACCCAGTTGA CCTTTAATTGACGCTTTCCAGACCAGCCCTGCGGCACCACTTGCCATGCGGGAGGCCACCAGGGTGTGCAAGCCTGGCTGCCATTCCAGT CTGTCCTGTCTGGGAATCGCCCTGTGGCCAGGCCCGCATGCTGGCCTCTGCCCAGGACTCCTCAGCATTTCCTCTTGGCATCCCTCCCCT CTCCCAGACCCTCTTCCAGCAGATGGCAAGGCCTCGGCATTGGGAAGTCAGGCACCTCTGCGGGCCCAGCCCCCTCCCGTGGCTCCCCTG >14501_14501_2_CD40-LAMC3_CD40_chr20_44751395_ENST00000372285_LAMC3_chr9_133901672_ENST00000361069_length(amino acids)=1585AA_BP=134 MVRLPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLR VQQKGTSETDTICTCEEGWHCTSEACESCVLHRSCSPGFGVKQIGKAYEITYVRLKFHTSRPESFAIYKRSRADGPWEPYQFYSASCQKT YGRPEGQYLRPGEDERVAFCTSEFSDISPLSGGNVAFSTLEGRPSAYNFEESPGLQEWVTSTELLISLDRLNTFGDDIFKDPKVLQSYYY AVSDFSVGGRCKCNGHASECGPDVAGQLACRCQHNTTGTDCERCLPFFQDRPWARGTAEAAHECLPCNCSGRSEECTFDRELFRSTGHGG RCHHCRDHTAGPHCERCQENFYHWDPRMPCQPCDCQSAGSLHLQCDDTGTCACKPTVTGWKCDRCLPGFHSLSEGGCRPCTCNPAGSLDT CDPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPAGCSSCFCYGHSKVCASTAQFQVHHILSDFHQGAEGWWARSVGGSEHPPQWSPNGV LLSPEDEEELTAPEKFLGDQRFSYGQPLILTFRVPPGDSPLPVQLRLEGTGLALSLRHSSLSGPQDAGHPREVELRFHLQETSEDVAPPL PPFHFQRLLANLTSLRLRVSPGPSPAGPVFLTEVRLTSARPGLSPPASWVEICSCPTGYTGQFCESCAPGYKREMPQGGPYASCVPCTCN QHGTCDPNTGICVCSHHTEGPSCERCLPGFYGNPFAGQADDCQPCPCPGQSACTTIPESREVVCTHCPPGQRGRRCEVCDDGFFGDPLGL FGHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHCEHCQEGFYGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCL PHVTARDCSRCYPGFFDLQPGRGCRSCKCHPLGSQEDQCHPKTGQCTCRPGVTGQACDRCQLGFFGFSIKGCRACRCSPLGAASAQCHEN GTCVCRPGFEGYKCDRCHDNFFLTADGTHCQQCPSCYALVKEEAAKLKARLTLTEGWLQGSDCGSPWGPLDILLGEAPRGDVYQGHHLLP GAREAFLEQMMSLEGAVKAAREQLQRLNKGARCAQAGSQKTCTQLADLEAVLESSEEEILHAAAILASLEIPQEGPSQPTKWSHLATEAR ALARSHRDTATKIAATAWRALLASNTSYALLWNLLEGRVALETQRDLEDRYQEVQAAQKALRTAVAEVLPEAESVLATVQQVGADTAPYL ALLASPGALPQKSRAEDLGLKAKALEKTVASWQHMATEAARTLQTAAQATLRQTEPLTKLHQEARAALTQASSSVQAATVTVMGARTLLA DLEGMKLQFPRPKDQAALQRKADSVSDRLLADTRKKTKQAERMLGNAAPLSSSAKKKGREAEVLAKDSAKLAKALLRERKQAHRRASRLT SQTQATLQQASQQVLASEARRQELEEAERVGAGLSEMEQQIRESRISLEKDIETLSELLARLGSLDTHQAPAQALNETQWALERLRLQLG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CD40-LAMC3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CD40-LAMC3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CD40-LAMC3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CD40 | C0003873 | Rheumatoid Arthritis | 3 | CTD_human |
| Hgene | CD40 | C1720957 | Hyper-IgM Immunodeficiency Syndrome, Type 3 | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Hgene | CD40 | C0026691 | Mucocutaneous Lymph Node Syndrome | 2 | CTD_human |
| Hgene | CD40 | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
| Hgene | CD40 | C0020456 | Hyperglycemia | 1 | CTD_human |
| Hgene | CD40 | C0020459 | Hyperinsulinism | 1 | CTD_human |
| Hgene | CD40 | C0021655 | Insulin Resistance | 1 | CTD_human |
| Hgene | CD40 | C0026769 | Multiple Sclerosis | 1 | CTD_human |
| Hgene | CD40 | C0028754 | Obesity | 1 | CTD_human |
| Hgene | CD40 | C0038220 | Status Epilepticus | 1 | CTD_human |
| Hgene | CD40 | C0270823 | Petit mal status | 1 | CTD_human |
| Hgene | CD40 | C0311335 | Grand Mal Status Epilepticus | 1 | CTD_human |
| Hgene | CD40 | C0393734 | Complex Partial Status Epilepticus | 1 | CTD_human |
| Hgene | CD40 | C0678222 | Breast Carcinoma | 1 | CTD_human |
| Hgene | CD40 | C0751324 | Multiple Sclerosis, Acute Fulminating | 1 | CTD_human |
| Hgene | CD40 | C0751522 | Status Epilepticus, Subclinical | 1 | CTD_human |
| Hgene | CD40 | C0751523 | Non-Convulsive Status Epilepticus | 1 | CTD_human |
| Hgene | CD40 | C0751524 | Simple Partial Status Epilepticus | 1 | CTD_human |
| Hgene | CD40 | C0920563 | Insulin Sensitivity | 1 | CTD_human |
| Hgene | CD40 | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| Hgene | CD40 | C1257963 | Endogenous Hyperinsulinism | 1 | CTD_human |
| Hgene | CD40 | C1257964 | Exogenous Hyperinsulinism | 1 | CTD_human |
| Hgene | CD40 | C1257965 | Compensatory Hyperinsulinemia | 1 | CTD_human |
| Hgene | CD40 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | CD40 | C1855520 | Hyperglycemia, Postprandial | 1 | CTD_human |
| Hgene | CD40 | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
| Tgene | C1510586 | Autism Spectrum Disorders | 2 | CTD_human | |
| Tgene | C0006111 | Brain Diseases | 1 | CTD_human | |
| Tgene | C0026640 | Mouth Neoplasms | 1 | CTD_human | |
| Tgene | C0085584 | Encephalopathies | 1 | CTD_human | |
| Tgene | C0153381 | Malignant neoplasm of mouth | 1 | CTD_human | |
| Tgene | C3279875 | CORTICAL MALFORMATIONS, OCCIPITAL | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
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