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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NUP93-THADA (FusionGDB2 ID:HG9688TG63892)

Fusion Gene Summary for NUP93-THADA

check button Fusion gene summary
Fusion gene informationFusion gene name: NUP93-THADA
Fusion gene ID: hg9688tg63892
HgeneTgene
Gene symbol

NUP93

THADA

Gene ID

9688

63892

Gene namenucleoporin 93THADA armadillo repeat containing
SynonymsNIC96ARMC13|GITA
Cytomap('NUP93')('THADA')

16q13

2p21

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup9393 kDa nucleoporinnucleoporin 93kDanucleoporin Nup93thyroid adenoma-associated proteindeath receptor-interacting proteingene inducing thyroid adenomas protein
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000569595, ENST00000308159, 
ENST00000569842, ENST00000564887, 
ENST00000542526, 
Fusion gene scores* DoF score7 X 6 X 6=25219 X 13 X 11=2717
# samples 820
** MAII scorelog2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/2717*10)=-3.76394266044725
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUP93 [Title/Abstract] AND THADA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNUP93(56792567)-THADA(43460021), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNUP93

GO:0006998

nuclear envelope organization

26878725

HgeneNUP93

GO:0051292

nuclear pore complex assembly

26878725

HgeneNUP93

GO:0060391

positive regulation of SMAD protein signal transduction

26878725

HgeneNUP93

GO:0060395

SMAD protein signal transduction

26878725



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-NA-A4QV-01ANUP93chr16

56792567

-THADAchr2

43460021

-
ChimerDB4UCSTCGA-NA-A4QV-01ANUP93chr16

56792567

+THADAchr2

43460021

-
ChimerDB4UCSTCGA-NA-A4QVNUP93chr16

56792567

+THADAchr2

43460021

-
ChimerDB4UCSTCGA-NA-A4QVNUP93chr16

56816126

+THADAchr2

43460021

-


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Fusion Gene ORF analysis for NUP93-THADA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000569595ENST00000330266NUP93chr16

56816126

+THADAchr2

43460021

-
3UTR-intronENST00000569595ENST00000402360NUP93chr16

56816126

+THADAchr2

43460021

-
3UTR-intronENST00000569595ENST00000403856NUP93chr16

56816126

+THADAchr2

43460021

-
3UTR-intronENST00000569595ENST00000404790NUP93chr16

56816126

+THADAchr2

43460021

-
3UTR-intronENST00000569595ENST00000405006NUP93chr16

56816126

+THADAchr2

43460021

-
3UTR-intronENST00000569595ENST00000405975NUP93chr16

56816126

+THADAchr2

43460021

-
3UTR-intronENST00000569595ENST00000415080NUP93chr16

56816126

+THADAchr2

43460021

-
3UTR-intronENST00000569595ENST00000485353NUP93chr16

56816126

+THADAchr2

43460021

-
5CDS-intronENST00000308159ENST00000330266NUP93chr16

56792567

+THADAchr2

43460021

-
5CDS-intronENST00000308159ENST00000402360NUP93chr16

56792567

+THADAchr2

43460021

-
5CDS-intronENST00000308159ENST00000403856NUP93chr16

56792567

+THADAchr2

43460021

-
5CDS-intronENST00000308159ENST00000404790NUP93chr16

56792567

+THADAchr2

43460021

-
5CDS-intronENST00000308159ENST00000405006NUP93chr16

56792567

+THADAchr2

43460021

-
5CDS-intronENST00000308159ENST00000405975NUP93chr16

56792567

+THADAchr2

43460021

-
5CDS-intronENST00000308159ENST00000415080NUP93chr16

56792567

+THADAchr2

43460021

-
5CDS-intronENST00000308159ENST00000485353NUP93chr16

56792567

+THADAchr2

43460021

-
5CDS-intronENST00000569842ENST00000330266NUP93chr16

56792567

+THADAchr2

43460021

-
5CDS-intronENST00000569842ENST00000402360NUP93chr16

56792567

+THADAchr2

43460021

-
5CDS-intronENST00000569842ENST00000403856NUP93chr16

56792567

+THADAchr2

43460021

-
5CDS-intronENST00000569842ENST00000404790NUP93chr16

56792567

+THADAchr2

43460021

-
5CDS-intronENST00000569842ENST00000405006NUP93chr16

56792567

+THADAchr2

43460021

-
5CDS-intronENST00000569842ENST00000405975NUP93chr16

56792567

+THADAchr2

43460021

-
5CDS-intronENST00000569842ENST00000415080NUP93chr16

56792567

+THADAchr2

43460021

-
5CDS-intronENST00000569842ENST00000485353NUP93chr16

56792567

+THADAchr2

43460021

-
5UTR-intronENST00000564887ENST00000330266NUP93chr16

56816126

+THADAchr2

43460021

-
5UTR-intronENST00000564887ENST00000402360NUP93chr16

56816126

+THADAchr2

43460021

-
5UTR-intronENST00000564887ENST00000403856NUP93chr16

56816126

+THADAchr2

43460021

-
5UTR-intronENST00000564887ENST00000404790NUP93chr16

56816126

+THADAchr2

43460021

-
5UTR-intronENST00000564887ENST00000405006NUP93chr16

56816126

+THADAchr2

43460021

-
5UTR-intronENST00000564887ENST00000405975NUP93chr16

56816126

+THADAchr2

43460021

-
5UTR-intronENST00000564887ENST00000415080NUP93chr16

56816126

+THADAchr2

43460021

-
5UTR-intronENST00000564887ENST00000485353NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000308159ENST00000330266NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000308159ENST00000402360NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000308159ENST00000403856NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000308159ENST00000404790NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000308159ENST00000405006NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000308159ENST00000405975NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000308159ENST00000415080NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000308159ENST00000485353NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000542526ENST00000330266NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000542526ENST00000330266NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000542526ENST00000402360NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000542526ENST00000402360NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000542526ENST00000403856NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000542526ENST00000403856NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000542526ENST00000404790NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000542526ENST00000404790NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000542526ENST00000405006NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000542526ENST00000405006NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000542526ENST00000405975NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000542526ENST00000405975NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000542526ENST00000415080NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000542526ENST00000415080NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000542526ENST00000485353NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000542526ENST00000485353NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000564887ENST00000330266NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000564887ENST00000402360NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000564887ENST00000403856NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000564887ENST00000404790NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000564887ENST00000405006NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000564887ENST00000405975NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000564887ENST00000415080NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000564887ENST00000485353NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000569595ENST00000330266NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000569595ENST00000402360NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000569595ENST00000403856NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000569595ENST00000404790NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000569595ENST00000405006NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000569595ENST00000405975NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000569595ENST00000415080NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000569595ENST00000485353NUP93chr16

56792567

+THADAchr2

43460021

-
intron-intronENST00000569842ENST00000330266NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000569842ENST00000402360NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000569842ENST00000403856NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000569842ENST00000404790NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000569842ENST00000405006NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000569842ENST00000405975NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000569842ENST00000415080NUP93chr16

56816126

+THADAchr2

43460021

-
intron-intronENST00000569842ENST00000485353NUP93chr16

56816126

+THADAchr2

43460021

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NUP93-THADA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for NUP93-THADA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:56792567/:43460021)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NUP93-THADA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NUP93-THADA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NUP93-THADA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NUP93-THADA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNUP93C1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1CTD_human;ORPHANET
HgeneNUP93C4225166NEPHROTIC SYNDROME, TYPE 121CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human