|
Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:HDAC4-CUL3 (FusionGDB2 ID:HG9759TG8452) |
Fusion Gene Summary for HDAC4-CUL3 |
Fusion gene summary |
Fusion gene information | Fusion gene name: HDAC4-CUL3 | Fusion gene ID: hg9759tg8452 | Hgene | Tgene | Gene symbol | HDAC4 | CUL3 | Gene ID | 9759 | 8452 |
Gene name | histone deacetylase 4 | cullin 3 | |
Synonyms | AHO3|BDMR|HA6116|HD4|HDAC-4|HDAC-A|HDACA | CUL-3|PHA2E | |
Cytomap | ('HDAC4')('CUL3') 2q37.3 | 2q36.2 | |
Type of gene | protein-coding | protein-coding | |
Description | histone deacetylase 4histone deacetylase A | cullin-3 | |
Modification date | 20200329 | 20200327 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000345617, ENST00000541256, ENST00000543185, ENST00000553145, | ||
Fusion gene scores | * DoF score | 13 X 10 X 9=1170 | 8 X 8 X 5=320 |
# samples | 15 | 9 | |
** MAII score | log2(15/1170*10)=-2.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/320*10)=-1.83007499855769 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HDAC4 [Title/Abstract] AND CUL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | HDAC4(240048151)-CUL3(225422573), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | HDAC4-CUL3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HDAC4-CUL3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HDAC4-CUL3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HDAC4-CUL3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HDAC4-CUL3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. HDAC4-CUL3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. HDAC4-CUL3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. HDAC4-CUL3 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | HDAC4 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10869435|16236793 |
Hgene | HDAC4 | GO:0006338 | chromatin remodeling | 18850004 |
Hgene | HDAC4 | GO:0006476 | protein deacetylation | 27708256 |
Hgene | HDAC4 | GO:0016575 | histone deacetylation | 10869435 |
Hgene | HDAC4 | GO:0033235 | positive regulation of protein sumoylation | 17696781 |
Hgene | HDAC4 | GO:0034983 | peptidyl-lysine deacetylation | 18614528 |
Hgene | HDAC4 | GO:0045892 | negative regulation of transcription, DNA-templated | 10869435 |
Hgene | HDAC4 | GO:0070932 | histone H3 deacetylation | 12590135 |
Hgene | HDAC4 | GO:0070933 | histone H4 deacetylation | 12590135 |
Tgene | CUL3 | GO:0000209 | protein polyubiquitination | 19261606 |
Tgene | CUL3 | GO:0006511 | ubiquitin-dependent protein catabolic process | 25401743|27561354 |
Tgene | CUL3 | GO:0006513 | protein monoubiquitination | 22358839 |
Tgene | CUL3 | GO:0006888 | ER to Golgi vesicle-mediated transport | 22358839 |
Tgene | CUL3 | GO:0016567 | protein ubiquitination | 17543862|19782033|19995937|20389280|23213400 |
Tgene | CUL3 | GO:0031145 | anaphase-promoting complex-dependent catabolic process | 10500095 |
Tgene | CUL3 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 19261606|19782033|20389280 |
Tgene | CUL3 | GO:0071630 | nuclear protein quality control by the ubiquitin-proteasome system | 27561354 |
Fusion gene breakpoints across HDAC4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across CUL3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-VQ-A94O | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
Top |
Fusion Gene ORF analysis for HDAC4-CUL3 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000345617 | ENST00000409096 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
5CDS-5UTR | ENST00000345617 | ENST00000409777 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
5CDS-5UTR | ENST00000541256 | ENST00000409096 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
5CDS-5UTR | ENST00000541256 | ENST00000409777 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
5CDS-5UTR | ENST00000543185 | ENST00000409096 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
5CDS-5UTR | ENST00000543185 | ENST00000409777 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
5CDS-intron | ENST00000345617 | ENST00000344951 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
5CDS-intron | ENST00000345617 | ENST00000432260 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
5CDS-intron | ENST00000541256 | ENST00000344951 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
5CDS-intron | ENST00000541256 | ENST00000432260 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
5CDS-intron | ENST00000543185 | ENST00000344951 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
5CDS-intron | ENST00000543185 | ENST00000432260 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
Frame-shift | ENST00000543185 | ENST00000264414 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
In-frame | ENST00000345617 | ENST00000264414 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
In-frame | ENST00000541256 | ENST00000264414 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
intron-3CDS | ENST00000553145 | ENST00000264414 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
intron-5UTR | ENST00000553145 | ENST00000409096 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
intron-5UTR | ENST00000553145 | ENST00000409777 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
intron-intron | ENST00000553145 | ENST00000344951 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
intron-intron | ENST00000553145 | ENST00000432260 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000345617 | HDAC4 | chr2 | 240048151 | - | ENST00000264414 | CUL3 | chr2 | 225422573 | - | 8646 | 2310 | 783 | 4550 | 1255 |
ENST00000541256 | HDAC4 | chr2 | 240048151 | - | ENST00000264414 | CUL3 | chr2 | 225422573 | - | 7853 | 1517 | 35 | 3757 | 1240 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000345617 | ENST00000264414 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - | 0.000588556 | 0.99941146 |
ENST00000541256 | ENST00000264414 | HDAC4 | chr2 | 240048151 | - | CUL3 | chr2 | 225422573 | - | 0.000127956 | 0.99987197 |
Top |
Fusion Genomic Features for HDAC4-CUL3 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Top |
Fusion Protein Features for HDAC4-CUL3 |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:240048151/chr2:225422573) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | HDAC4 | chr2:240048151 | chr2:225422573 | ENST00000345617 | - | 12 | 27 | 67_177 | 506 | 1085.0 | Coiled coil | Ontology_term=ECO:0000255 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | HDAC4 | chr2:240048151 | chr2:225422573 | ENST00000345617 | - | 12 | 27 | 1051_1084 | 506 | 1085.0 | Motif | Nuclear export signal |
Hgene | HDAC4 | chr2:240048151 | chr2:225422573 | ENST00000345617 | - | 12 | 27 | 655_1084 | 506 | 1085.0 | Region | Note=Histone deacetylase |
Top |
Fusion Gene Sequence for HDAC4-CUL3 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>35831_35831_1_HDAC4-CUL3_HDAC4_chr2_240048151_ENST00000345617_CUL3_chr2_225422573_ENST00000264414_length(transcript)=8646nt_BP=2310nt GGAGGTTGTGGGGCCGCCGCCGCGGAGCACCGTCCCCGCCGCCGCCCGAGCCCGAGCCCGAGCCCGCGCACCCGCCCGCGCCGCCGCCGC CGCCGCCCGAACAGCCTCCCAGCCTGGGCCCCCGGCGGCGCCGTGGCCGCGTCCCGGCTGTCGCCGCCCGAGCCCGAGCCCGCGCGCCGG CGGGTGGCGGCGCAGGCTGAGGAGATGCGGCGCGGAGCGCCGGAGCAGGGCTAGAGCCGGCCGCCGCCGCCCGCCGCGGTAAGCGCAGCC CCGGCCCGGCGCCCGCGGGCCATTGTCCGCCGCCCGCCCCGCGCCCCGCGCAGCCTGCAGGCCTTGGAGCCCGCGGCAGGTGGACGCCGC CGGTCCACACCCGCCCCGCGCGCGGCCGTGGGAGGCGGGGGCCAGCGCTGGCCGCGCGCCGTGGGACCCGCCGGTCCCCAGGGCCGCCCG GCCCCTTCTGGACCTTTCCACCCGCGCCGCGAGGCGGCTTCGCCCGCCGGGGCGGGGGCGCGGGGGTGGGCACGGCAGGCAGCGGCGCCG TCTCCCGGTGCGGGGCCCGCGCCCCCCGAGCAGGTTCATCTGCAGAAGCCAGCGGACGCCTCTGTTCAACTTGTGGGTTACCTGGCTCAT GAGACCTTGCCGGCGAGGCTCGGCGCTTGAACGTCTGTGACCCAGCCCTCACCGTCCCGGTACTTGTATGTGTTGGTGGGAGTTTGGAGC TCGTTGGAGCTATCGTTTCCGTGGAAATTTTGAGCCATTTCGAATCACTTAAAGGAGTGGACATTGCTAGCAATGAGCTCCCAAAGCCAT CCAGATGGACTTTCTGGCCGAGACCAGCCAGTGGAGCTGCTGAATCCTGCCCGCGTGAACCACATGCCCAGCACGGTGGATGTGGCCACG GCGCTGCCTCTGCAAGTGGCCCCCTCGGCAGTGCCCATGGACCTGCGCCTGGACCACCAGTTCTCACTGCCTGTGGCAGAGCCGGCCCTG CGGGAGCAGCAGCTGCAGCAGGAGCTCCTGGCGCTCAAGCAGAAGCAGCAGATCCAGAGGCAGATCCTCATCGCTGAGTTCCAGAGGCAG CACGAGCAGCTCTCCCGGCAGCACGAGGCGCAGCTCCACGAGCACATCAAGCAACAACAGGAGATGCTGGCCATGAAGCACCAGCAGGAG CTGCTGGAACACCAGCGGAAGCTGGAGAGGCACCGCCAGGAGCAGGAGCTGGAGAAGCAGCACCGGGAGCAGAAGCTGCAGCAGCTCAAG AACAAGGAGAAGGGCAAAGAGAGTGCCGTGGCCAGCACAGAAGTGAAGATGAAGTTACAAGAATTTGTCCTCAATAAAAAGAAGGCGCTG GCCCACCGGAATCTGAACCACTGCATTTCCAGCGACCCTCGCTACTGGTACGGGAAAACGCAGCACAGTTCCCTTGACCAGAGTTCTCCA CCCCAGAGCGGAGTGTCGACCTCCTATAACCACCCGGTCCTGGGAATGTACGACGCCAAAGATGACTTCCCTCTTAGGAAAACAGCTTCT GAACCGAATCTGAAATTACGGTCCAGGCTAAAGCAGAAAGTGGCCGAAAGACGGAGCAGCCCCCTGTTACGCAGGAAAGACGGGCCAGTG GTCACTGCTCTAAAAAAGCGTCCGTTGGATGTCACAGACTCCGCGTGCAGCAGCGCCCCAGGCTCCGGACCCAGCTCACCCAACAACAGC TCCGGGAGCGTCAGCGCGGAGAACGGTATCGCGCCCGCCGTCCCCAGCATCCCGGCGGAGACGAGTTTGGCGCACAGACTTGTGGCACGA GAAGGCTCGGCCGCTCCACTTCCCCTCTACACATCGCCATCCTTGCCCAACATCACGCTGGGCCTGCCTGCCACCGGCCCCTCTGCGGGC ACGGCGGGCCAGCAGGACGCCGAGAGACTCACCCTTCCCGCCCTCCAGCAGAGGCTCTCCCTTTTCCCCGGCACCCACCTCACTCCCTAC CTGAGCACCTCGCCCTTGGAGCGGGACGGAGGGGCAGCGCACAGCCCTCTTCTGCAGCACATGGTCTTACTGGAGCAGCCGCCGGCACAA GCACCCCTCGTCACAGGCCTGGGAGCACTGCCCCTCCACGCACAGTCCTTGGTTGGTGCAGACCGGGTGTCCCCCTCCATCCACAAGCTG CGGCAGCACCGCCCACTGGGGCGGACCCAGTCGGCCCCGCTGCCCCAGAACGCCCAGGCTCTGCAGCACCTGGTCATCCAGCAGCAGCAT CAGCAGTTTCTGGAGAAACACAAGCAGCAGTTCCAGCAGCAGCAACTGCAGATGAACAAGATGACCATGGATGAAAAATATGTAAACAGC ATTTGGGACCTTCTGAAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATAT ACAATGGTTTTGCATAAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGAT GTACTAAATTCATTGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATA CTAATGTACATGGACCGTGTGTATGTACAACAAAATAATGTGGAGAACGTCTACAATTTGGGATTAATTATTTTTCGAGATCAAGTTGTA CGTTATGGGTGTATTAGGGATCATCTACGGCAAACTCTATTGGATATGATTGCAAGAGAGCGGAAAGGAGAAGTCGTAGACAGAGGCGCA ATAAGAAATGCTTGCCAGATGTTAATGATTTTAGGTCTCGAAGGAAGATCAGTCTATGAAGAAGATTTTGAGGCTCCTTTTTTGGAAATG TCTGCAGAATTTTTTCAGATGGAAAGCCAGAAATTTTTAGCAGAAAATAGTGCTTCAGTATATATAAAGAAAGTAGAAGCTAGAATTAAT GAAGAAATAGAACGAGTGATGCACTGCCTTGACAAATCAACGGAAGAACCAATTGTAAAGGTGGTTGAAAGGGAACTCATTTCCAAGCAC ATGAAGACTATAGTAGAAATGGAGAATTCTGGGCTAGTACATATGTTGAAAAATGGAAAGACAGAAGACCTTGGTTGCATGTACAAGTTA TTTAGTCGTGTGCCAAATGGTTTGAAAACAATGTGTGAGTGTATGAGTTCCTATTTGAGGGAGCAAGGTAAAGCTCTTGTTTCTGAAGAA GGAGAAGGAAAGAATCCTGTTGACTATATCCAGGGCTTATTGGATCTGAAGAGTAGGTTCGATCGCTTCCTCCTGGAATCATTCAACAAT GACCGTCTCTTTAAACAAACTATTGCGGGTGACTTTGAGTATTTTCTCAACCTCAACTCCAGGTCTCCTGAATACCTCTCATTATTTATT GATGATAAGCTGAAAAAGGGAGTCAAAGGGCTAACAGAACAAGAAGTAGAAACAATATTGGATAAAGCAATGGTCCTTTTTAGGTTTATG CAAGAAAAAGATGTATTTGAACGTTATTATAAACAACACTTGGCAAGGAGACTTCTCACAAATAAAAGTGTTTCTGATGACTCTGAAAAA AACATGATATCTAAGTTAAAGACTGAATGTGGATGTCAGTTCACGTCAAAACTGGAAGGAATGTTTAGGGATATGAGCATCTCAAACACA ACGATGGATGAATTCAGGCAACATCTACAGGCAACTGGTGTATCTTTAGGTGGTGTTGATCTTACAGTCCGGGTGCTCACGACAGGATAT TGGCCCACTCAGTCAGCCACACCAAAGTGCAACATCCCACCAGCACCAAGACATGCTTTTGAGATATTCAGAAGGTTCTACTTAGCCAAA CACAGTGGTCGACAGCTCACACTCCAGCATCATATGGGTTCTGCAGATCTCAATGCCACATTTTATGGACCAGTTAAAAAGGAAGATGGA TCTGAAGTTGGTGTTGGAGGTGCACAAGTAACTGGCTCTAATACACGGAAGCACATATTGCAAGTTTCCACTTTCCAGATGACCATATTA ATGCTCTTTAATAATAGAGAAAAATACACATTTGAGGAAATTCAGCAAGAGACAGATATCCCTGAAAGAGAGCTTGTTAGAGCCCTACAG TCCCTCGCCTGTGGTAAACCAACACAGCGGGTTCTTACAAAAGAACCCAAATCAAAGGAAATAGAAAATGGTCATATATTTACAGTTAAT GATCAATTCACATCCAAACTACACAGAGTCAAGATTCAAACAGTTGCTGCCAAACAAGGTGAATCCGACCCAGAGAGGAAAGAAACAAGG CAGAAAGTAGACGACGACAGAAAACATGAGATAGAAGCTGCTATAGTGCGGATAATGAAATCTAGAAAGAAGATGCAGCACAATGTTCTA GTAGCGGAGGTAACTCAGCAGTTGAAGGCGCGATTCTTACCAAGTCCAGTTGTTATTAAGAAACGTATTGAAGGACTTATTGAGAGAGAA TATTTGGCACGAACACCTGAGGATCGCAAAGTATACACATATGTAGCATAAAATGCGTTCAGAAATTTGATTTATTCTTGGACTGTACTC TTCGCATGGACTGGGAAGTTCTTTTAAATCATTAAATATTAAGACGACCATCTCTTCTATTAAATTACAGTACATGTTCTAGACCATTGA GATCAAGCCTTTACTCCCTTTGAGAGTTTCCAACATCAGTTGATTGAGCTTCAGGCTTTACAACGTTTATCCCTGTAGAGATCATCTTTA CAGTTCCTCGGGAAAATGTGAATGTGCTGCGTTTTGTTTTCTTTACTGTATGAAAACAGGAAAATAAAAGAGAAATTTAGAAAATACAGC TCATTACAATAAAATTGTTGGATTTCATTTCCCCAGGTCTTCAGTGTTGATGTAAATGTGTTTTGTAGTGTTGCTTAGCACTTTGCGCAT TGTGTAAGTTGGGTAACAAAAATGGCAAAAGAAATGCAGATTTCCCAGTTATCTTGCTCTGAAGACATTTCTTTAGCTAGTCTTATTTAA TTTTAAAGGTTTGATAAATATACAAAGACCCAAGCATACAATTTGAGCATGCTGTATTCTACCACTTGCACTTACTCATCTTCTAGCCTT ATGACCAGGAACCTTTGTTTTGGGCTCAAGTACACATCCTGATTTGGTTTCTCCCTGTTGTAATTTGAGATTTCCCAAATTAAGTCTTAT AATGATTAGGTTTTGTTCTGAGTTATTTCTAGAGAAAGAAAGTATTTTAGTATGTGTAAATTGTACAATAATTTTTTTGCTGTTGTACTC ACTGCTAATAGTGGATTGTATAGGGTGGTGTTTTTATTTCATTTATTGTAGACAAAAATAATGAATTTAGTATACACATACCCACTAATT CAAGTATGTCAGAGCACAAAGTTGGCAGCTGGTTATATTTAATTCAGCCCCTCTGAAAAGCACATACAGTCTATACTTTGTTTATAAATA CCCTAGGTCCTCCCTGCCCCTAAATATATATTTTGGTGAAGCTGTGGTGCACTATTAATTTTCTGTTTCAAAATGCAATCTAAAGATGCA ATAAATATGATGACCTTGATAGTTTTAATGAAATCTTCAATTCTTGCAGCTGTGTTTTGGAAAGTGATTAAGCAATATTTCTCAAACCTG ATGATTCTTGGATATTTAGCTATTGTCCTCCAAAGAGTCATCGTTTCACGTTTTCAAACATGTGCTTTGTGCTGAAGATTCTTGTCAGAT ATCCTGTGCTTCCAGAGTATTTTTATCTTCAATTTTATTTAATTTTGTTTCATTTTGTTTTCATAAGACAATGTTTCAGATATGTAATGG GGCAAACCACTATAGATTTCTGTTGGATAGAAAAATGAAATGTTACTAATAAGTTTAAATTGACCCTTCGTTGACTATCAGTACTGTTGA TACATTTATTAGAATGTATGTCTCAGAAGATGGTTTCTGTTTAAATTTATGGTCAAGTTACAACAACTGAATTCTAATATGGATTAAAAA CTCCACATAAATATTTTTCCCCATGCGTCTTGGGTTATAATTTTCCTTTTAGACTTGCAAATATGCTTTTATTGCAATTTTGTCTCCATC TGTACTGTAGAATTACAAGCCTTGTGCTCTTTATCTCTACATTTTCCACTTCTACATGATGCAATTAAGATGCCAATGAAAAGTATTGTG AACATTATTCTCAGGACACTTTTACCATACTTGAGTAGTACTAAGTCAGGTGTAACATGGAAAGCTAAGGGTTTCACCTTCTGATTTTGA CATAATTGGAAATTTTCTATAATGGTAAGATGTTTATAGGAAAGTAATGGTAGTTCATGTTTGAGAATTTTTTTATTGCTTTCATTTCCC AGTTAAATGATATTTAACACCTGGGAAAACAGGACAGCTCAGATTGTCGAGTTAGTAAACATGAGCGATGTAAAAACTTTATTTGAAATC TCCTAAGTGAGACATTAAACATTTTAGTGCTAGTTTAAGCCATTAAAAGTAAAGTTTAAGTTTACGTCATTGTCTCAAGTGTGGCTGTAA AAATCAGATCTAGAGTTTAGAGACATACTTGTTAACTTTGGAGCACAGGTTTGATATTTATGCTTCTAAATACATTAAAACATTTCTGAA TTGCAGTTGAATGGTTGGAGATTGCTGGCGATGTGATGCTGCACTGAAAAAACTGGTCACACAAAATGTTTATATGTTTGACTGCATAAG TATTATTTTAGGTCATAAAGGTTATAACAAAATACATTTAACATTGCTTTCTTTTTAGCAAGAGGTCACAGATGCTATTTTTTCTCAGTT TTTAATGCTTTAATTTGAAAGAAAAATGCATCCTAACCATTCCATCCTGTTGGTGCAGAGAAATTTTGGTGATTTATTAGAAGACTTTTA AGGAGGGTGGATACATAGTTTTTCAACTGCAAAAATCATGTCATCTCTTCAGTAACTGTTAAAGTGTAATTCTCTGCCTTCATTATCAAG TCCAGGACAGTGTTTATTTTGAATCGTTAACATTATTTAAAGACTGAAAATTCATTGCAATTAGGGAACGCACAGCCTCACAAAAAGTGG TTGTGATTGCAAGGATTCTTTATGTCAGTGAACTTAAAAAGGGAATGGGGGAAGAGATGCATGCCTTTCTAAAGGTATGCTAGAGTCACC TGTGTAGCATTGTAATTATGTACTATCAAACCCCCAAGATGCTGATGATAGGCCTTCTCTGTAAGAATCCTTCTCATAGTGAAGCACTGT TGATGTTTTGTTCACCGGATATGTTGGGTAGCAGAAAAGGCCTAGAACCAGTTTTAAGATTATGCCTACATCTCTAGAAGACTAGTACAC TGGCATCATCTTAGGTTTCTAAATATTATTTAATTCCTTAATTTGGAAAGCAGTTTTAATGTTTACAGTTTAAGATACTCATTTTCAGTA ACTAGTGTTAAAGATTTTTATCTTTGCCTGTCTACTGTAACTTAAGACTTTCATAGAATAATTTTTTATAGAGTATATGGTATATTGTGT CAATCTTGGAAGGAAAGCTGTTGCATATCAATTGTAGGTCATGTATTTTACTATATGTTGCATAGTATTTTGCATTCTGTAAATACGAAT GTTAAAACATTTCAGGTCAGCAAAATTAGAAGTCATTTCTAGTCCTCAAAGCAGAAATAATTAGAAATGTTAACATTTAAGTGCTTATCA TATGCCAGATACTATTCTGAATATTTTATGTATATTCATTCATTTAGTTGTCATATTGGCTTTATGTGACATAACTGTCATTATACCAGT GTTGTCCAAGGTTGCTAGCAGGAAATGGCAGAGCCAGGAGTTGGACCTAGGTTTAATCCTATCCATATTCCATGTTACAAATTGACATGA TTTTCCATATTAAAAAATTTTCATTTATTTTGTACCTCATTCACATGAATAGTAATGTGACAAACTAAAGTTAATACATGAAGCATTGCA ATATGGAATTTTGCACATTTTTGTTAGCTTTACATTATTTGCTGATACCAACTTTTGGTAGGAAGGAAAACAGGGAAGGTGATTGCTGCT ATTCTGGAATGTGTCCATTGAAAAGAAAATAGGCGCTTTGTCTCCTACAATCTTAGAGAAAGTTTTACATACTTAAGTGGGTACCACAGA TAGGCATGTACCTTAAATTCAAATCTACAGTTTTACAAAATGTTTTCCTTTGTGTGCCTTTCCTATGTCAAATTAGCCAGAAGGAAGAAG AGACGTTAAGAATGGCAGATAAATTTAACAGGTAATGATACAGAGATTGGCCATTACGCCAGCTCTCAGGAGAAAAACAACTAGGATGTC TTGAAACCCGTGCATTTAATTTTAGAAATGGCAAATTTGTAAGCGTGTCATTTAAGTAATTTGATGCTCAGTTTTAGGGTCTAAGTTGAC CTCGAGTGAGCCATGCAAAAATAGCTTTAAAATTATACATGAGCAGCTCAAAGTAAACGTGTATTTTTTAGTAACAATGAAATTGTCAAA TTTCAAGATTTTAATAACAGGACAGTTCAACTAATAAACTTTATTGCATACAAGATTTATTGCAATGTGGGAAAATTAAAATTCTCAGTC >35831_35831_1_HDAC4-CUL3_HDAC4_chr2_240048151_ENST00000345617_CUL3_chr2_225422573_ENST00000264414_length(amino acids)=1255AA_BP=509 MLAMSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQ ILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQE FVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSP LLRRKDGPVVTALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLG LPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVTGLGALPLHAQSLVGAD RVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLS FEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLG LIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVY IKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLRE QGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILD KAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDL TVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQ VSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVNDQFTSKLHRVKIQTVAAKQGE -------------------------------------------------------------- >35831_35831_2_HDAC4-CUL3_HDAC4_chr2_240048151_ENST00000541256_CUL3_chr2_225422573_ENST00000264414_length(transcript)=7853nt_BP=1517nt AGTTTTCGGCAGAGTCGCGTGTCTGAGAAGTGACGCTGGGATGTCCCTGGGCTGTGCCAGGAGCAGTGCTGGCTCAGATGGATGTGGCCA CGGCGCTGCCTCTGCAAGTGGCCCCCTCGGCAGTGCCCATGGACCTGCGCCTGGACCACCAGTTCTCACTGCCTGTGGCAGAGCCGGCCC TGCGGGAGCAGCAGCTGCAGCAGGAGCTCCTGGCGCTCAAGCAGAAGCAGCAGATCCAGAGGCAGATCCTCATCGCTGAGTTCCAGAGGC AGCACGAGCAGCTCTCCCGGCAGCACGAGGCGCAGCTCCACGAGCACATCAAGCAACAACAGGAGATGCTGGCCATGAAGCACCAGCAGG AGCTGCTGGAACACCAGCGGAAGCTGGAGAGGCACCGCCAGGAGCAGGAGCTGGAGAAGCAGCACCGGGAGCAGAAGCTGCAGCAGCTCA AGAACAAGGAGAAGGGCAAAGAGAGTGCCGTGGCCAGCACAGAAGTGAAGATGAAGTTACAAGAATTTGTCCTCAATAAAAAGAAGGCGC TGGCCCACCGGAATCTGAACCACTGCATTTCCAGCGACCCTCGCTACTGGTACGGGAAAACGCAGCACAGTTCCCTTGACCAGAGTTCTC CACCCCAGAGCGGAGTGTCGACCTCCTATAACCACCCGGTCCTGGGAATGTACGACGCCAAAGATGACTTCCCTCTTAGGAAAACAGCTT CTGAACCGAATCTGAAATTACGGTCCAGGCTAAAGCAGAAAGTGGCCGAAAGACGGAGCAGCCCCCTGTTACGCAGGAAAGACGGGCCAG TGGTCACTGCTCTAAAAAAGCGTCCGTTGGATGTCACAGACTCCGCGTGCAGCAGCGCCCCAGGCTCCGGACCCAGCTCACCCAACAACA GCTCCGGGAGCGTCAGCGCGGAGAACGGTATCGCGCCCGCCGTCCCCAGCATCCCGGCGGAGACGAGTTTGGCGCACAGACTTGTGGCAC GAGAAGGCTCGGCCGCTCCACTTCCCCTCTACACATCGCCATCCTTGCCCAACATCACGCTGGGCCTGCCTGCCACCGGCCCCTCTGCGG GCACGGCGGGCCAGCAGGACGCCGAGAGACTCACCCTTCCCGCCCTCCAGCAGAGGCTCTCCCTTTTCCCCGGCACCCACCTCACTCCCT ACCTGAGCACCTCGCCCTTGGAGCGGGACGGAGGGGCAGCGCACAGCCCTCTTCTGCAGCACATGGTCTTACTGGAGCAGCCGCCGGCAC AAGCACCCCTCGTCACAGACTGGTATCTTTCAGGCCTGGGAGCACTGCCCCTCCACGCACAGTCCTTGGTTGGTGCAGACCGGGTGTCCC CCTCCATCCACAAGCTGCGGCAGCACCGCCCACTGGGGCGGACCCAGTCGGCCCCGCTGCCCCAGAACGCCCAGGCTCTGCAGCACCTGG TCATCCAGCAGCAGCATCAGCAGTTTCTGGAGAAACACAAGCAGCAGTTCCAGCAGCAGCAACTGCAGATGAACAAGATGACCATGGATG AAAAATATGTAAACAGCATTTGGGACCTTCTGAAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGC TCTATAGAAATGCATATACAATGGTTTTGCATAAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAA ATAAGGTGCGAGAAGATGTACTAAATTCATTGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGG TGATGATTAGAGACATACTAATGTACATGGACCGTGTGTATGTACAACAAAATAATGTGGAGAACGTCTACAATTTGGGATTAATTATTT TTCGAGATCAAGTTGTACGTTATGGGTGTATTAGGGATCATCTACGGCAAACTCTATTGGATATGATTGCAAGAGAGCGGAAAGGAGAAG TCGTAGACAGAGGCGCAATAAGAAATGCTTGCCAGATGTTAATGATTTTAGGTCTCGAAGGAAGATCAGTCTATGAAGAAGATTTTGAGG CTCCTTTTTTGGAAATGTCTGCAGAATTTTTTCAGATGGAAAGCCAGAAATTTTTAGCAGAAAATAGTGCTTCAGTATATATAAAGAAAG TAGAAGCTAGAATTAATGAAGAAATAGAACGAGTGATGCACTGCCTTGACAAATCAACGGAAGAACCAATTGTAAAGGTGGTTGAAAGGG AACTCATTTCCAAGCACATGAAGACTATAGTAGAAATGGAGAATTCTGGGCTAGTACATATGTTGAAAAATGGAAAGACAGAAGACCTTG GTTGCATGTACAAGTTATTTAGTCGTGTGCCAAATGGTTTGAAAACAATGTGTGAGTGTATGAGTTCCTATTTGAGGGAGCAAGGTAAAG CTCTTGTTTCTGAAGAAGGAGAAGGAAAGAATCCTGTTGACTATATCCAGGGCTTATTGGATCTGAAGAGTAGGTTCGATCGCTTCCTCC TGGAATCATTCAACAATGACCGTCTCTTTAAACAAACTATTGCGGGTGACTTTGAGTATTTTCTCAACCTCAACTCCAGGTCTCCTGAAT ACCTCTCATTATTTATTGATGATAAGCTGAAAAAGGGAGTCAAAGGGCTAACAGAACAAGAAGTAGAAACAATATTGGATAAAGCAATGG TCCTTTTTAGGTTTATGCAAGAAAAAGATGTATTTGAACGTTATTATAAACAACACTTGGCAAGGAGACTTCTCACAAATAAAAGTGTTT CTGATGACTCTGAAAAAAACATGATATCTAAGTTAAAGACTGAATGTGGATGTCAGTTCACGTCAAAACTGGAAGGAATGTTTAGGGATA TGAGCATCTCAAACACAACGATGGATGAATTCAGGCAACATCTACAGGCAACTGGTGTATCTTTAGGTGGTGTTGATCTTACAGTCCGGG TGCTCACGACAGGATATTGGCCCACTCAGTCAGCCACACCAAAGTGCAACATCCCACCAGCACCAAGACATGCTTTTGAGATATTCAGAA GGTTCTACTTAGCCAAACACAGTGGTCGACAGCTCACACTCCAGCATCATATGGGTTCTGCAGATCTCAATGCCACATTTTATGGACCAG TTAAAAAGGAAGATGGATCTGAAGTTGGTGTTGGAGGTGCACAAGTAACTGGCTCTAATACACGGAAGCACATATTGCAAGTTTCCACTT TCCAGATGACCATATTAATGCTCTTTAATAATAGAGAAAAATACACATTTGAGGAAATTCAGCAAGAGACAGATATCCCTGAAAGAGAGC TTGTTAGAGCCCTACAGTCCCTCGCCTGTGGTAAACCAACACAGCGGGTTCTTACAAAAGAACCCAAATCAAAGGAAATAGAAAATGGTC ATATATTTACAGTTAATGATCAATTCACATCCAAACTACACAGAGTCAAGATTCAAACAGTTGCTGCCAAACAAGGTGAATCCGACCCAG AGAGGAAAGAAACAAGGCAGAAAGTAGACGACGACAGAAAACATGAGATAGAAGCTGCTATAGTGCGGATAATGAAATCTAGAAAGAAGA TGCAGCACAATGTTCTAGTAGCGGAGGTAACTCAGCAGTTGAAGGCGCGATTCTTACCAAGTCCAGTTGTTATTAAGAAACGTATTGAAG GACTTATTGAGAGAGAATATTTGGCACGAACACCTGAGGATCGCAAAGTATACACATATGTAGCATAAAATGCGTTCAGAAATTTGATTT ATTCTTGGACTGTACTCTTCGCATGGACTGGGAAGTTCTTTTAAATCATTAAATATTAAGACGACCATCTCTTCTATTAAATTACAGTAC ATGTTCTAGACCATTGAGATCAAGCCTTTACTCCCTTTGAGAGTTTCCAACATCAGTTGATTGAGCTTCAGGCTTTACAACGTTTATCCC TGTAGAGATCATCTTTACAGTTCCTCGGGAAAATGTGAATGTGCTGCGTTTTGTTTTCTTTACTGTATGAAAACAGGAAAATAAAAGAGA AATTTAGAAAATACAGCTCATTACAATAAAATTGTTGGATTTCATTTCCCCAGGTCTTCAGTGTTGATGTAAATGTGTTTTGTAGTGTTG CTTAGCACTTTGCGCATTGTGTAAGTTGGGTAACAAAAATGGCAAAAGAAATGCAGATTTCCCAGTTATCTTGCTCTGAAGACATTTCTT TAGCTAGTCTTATTTAATTTTAAAGGTTTGATAAATATACAAAGACCCAAGCATACAATTTGAGCATGCTGTATTCTACCACTTGCACTT ACTCATCTTCTAGCCTTATGACCAGGAACCTTTGTTTTGGGCTCAAGTACACATCCTGATTTGGTTTCTCCCTGTTGTAATTTGAGATTT CCCAAATTAAGTCTTATAATGATTAGGTTTTGTTCTGAGTTATTTCTAGAGAAAGAAAGTATTTTAGTATGTGTAAATTGTACAATAATT TTTTTGCTGTTGTACTCACTGCTAATAGTGGATTGTATAGGGTGGTGTTTTTATTTCATTTATTGTAGACAAAAATAATGAATTTAGTAT ACACATACCCACTAATTCAAGTATGTCAGAGCACAAAGTTGGCAGCTGGTTATATTTAATTCAGCCCCTCTGAAAAGCACATACAGTCTA TACTTTGTTTATAAATACCCTAGGTCCTCCCTGCCCCTAAATATATATTTTGGTGAAGCTGTGGTGCACTATTAATTTTCTGTTTCAAAA TGCAATCTAAAGATGCAATAAATATGATGACCTTGATAGTTTTAATGAAATCTTCAATTCTTGCAGCTGTGTTTTGGAAAGTGATTAAGC AATATTTCTCAAACCTGATGATTCTTGGATATTTAGCTATTGTCCTCCAAAGAGTCATCGTTTCACGTTTTCAAACATGTGCTTTGTGCT GAAGATTCTTGTCAGATATCCTGTGCTTCCAGAGTATTTTTATCTTCAATTTTATTTAATTTTGTTTCATTTTGTTTTCATAAGACAATG TTTCAGATATGTAATGGGGCAAACCACTATAGATTTCTGTTGGATAGAAAAATGAAATGTTACTAATAAGTTTAAATTGACCCTTCGTTG ACTATCAGTACTGTTGATACATTTATTAGAATGTATGTCTCAGAAGATGGTTTCTGTTTAAATTTATGGTCAAGTTACAACAACTGAATT CTAATATGGATTAAAAACTCCACATAAATATTTTTCCCCATGCGTCTTGGGTTATAATTTTCCTTTTAGACTTGCAAATATGCTTTTATT GCAATTTTGTCTCCATCTGTACTGTAGAATTACAAGCCTTGTGCTCTTTATCTCTACATTTTCCACTTCTACATGATGCAATTAAGATGC CAATGAAAAGTATTGTGAACATTATTCTCAGGACACTTTTACCATACTTGAGTAGTACTAAGTCAGGTGTAACATGGAAAGCTAAGGGTT TCACCTTCTGATTTTGACATAATTGGAAATTTTCTATAATGGTAAGATGTTTATAGGAAAGTAATGGTAGTTCATGTTTGAGAATTTTTT TATTGCTTTCATTTCCCAGTTAAATGATATTTAACACCTGGGAAAACAGGACAGCTCAGATTGTCGAGTTAGTAAACATGAGCGATGTAA AAACTTTATTTGAAATCTCCTAAGTGAGACATTAAACATTTTAGTGCTAGTTTAAGCCATTAAAAGTAAAGTTTAAGTTTACGTCATTGT CTCAAGTGTGGCTGTAAAAATCAGATCTAGAGTTTAGAGACATACTTGTTAACTTTGGAGCACAGGTTTGATATTTATGCTTCTAAATAC ATTAAAACATTTCTGAATTGCAGTTGAATGGTTGGAGATTGCTGGCGATGTGATGCTGCACTGAAAAAACTGGTCACACAAAATGTTTAT ATGTTTGACTGCATAAGTATTATTTTAGGTCATAAAGGTTATAACAAAATACATTTAACATTGCTTTCTTTTTAGCAAGAGGTCACAGAT GCTATTTTTTCTCAGTTTTTAATGCTTTAATTTGAAAGAAAAATGCATCCTAACCATTCCATCCTGTTGGTGCAGAGAAATTTTGGTGAT TTATTAGAAGACTTTTAAGGAGGGTGGATACATAGTTTTTCAACTGCAAAAATCATGTCATCTCTTCAGTAACTGTTAAAGTGTAATTCT CTGCCTTCATTATCAAGTCCAGGACAGTGTTTATTTTGAATCGTTAACATTATTTAAAGACTGAAAATTCATTGCAATTAGGGAACGCAC AGCCTCACAAAAAGTGGTTGTGATTGCAAGGATTCTTTATGTCAGTGAACTTAAAAAGGGAATGGGGGAAGAGATGCATGCCTTTCTAAA GGTATGCTAGAGTCACCTGTGTAGCATTGTAATTATGTACTATCAAACCCCCAAGATGCTGATGATAGGCCTTCTCTGTAAGAATCCTTC TCATAGTGAAGCACTGTTGATGTTTTGTTCACCGGATATGTTGGGTAGCAGAAAAGGCCTAGAACCAGTTTTAAGATTATGCCTACATCT CTAGAAGACTAGTACACTGGCATCATCTTAGGTTTCTAAATATTATTTAATTCCTTAATTTGGAAAGCAGTTTTAATGTTTACAGTTTAA GATACTCATTTTCAGTAACTAGTGTTAAAGATTTTTATCTTTGCCTGTCTACTGTAACTTAAGACTTTCATAGAATAATTTTTTATAGAG TATATGGTATATTGTGTCAATCTTGGAAGGAAAGCTGTTGCATATCAATTGTAGGTCATGTATTTTACTATATGTTGCATAGTATTTTGC ATTCTGTAAATACGAATGTTAAAACATTTCAGGTCAGCAAAATTAGAAGTCATTTCTAGTCCTCAAAGCAGAAATAATTAGAAATGTTAA CATTTAAGTGCTTATCATATGCCAGATACTATTCTGAATATTTTATGTATATTCATTCATTTAGTTGTCATATTGGCTTTATGTGACATA ACTGTCATTATACCAGTGTTGTCCAAGGTTGCTAGCAGGAAATGGCAGAGCCAGGAGTTGGACCTAGGTTTAATCCTATCCATATTCCAT GTTACAAATTGACATGATTTTCCATATTAAAAAATTTTCATTTATTTTGTACCTCATTCACATGAATAGTAATGTGACAAACTAAAGTTA ATACATGAAGCATTGCAATATGGAATTTTGCACATTTTTGTTAGCTTTACATTATTTGCTGATACCAACTTTTGGTAGGAAGGAAAACAG GGAAGGTGATTGCTGCTATTCTGGAATGTGTCCATTGAAAAGAAAATAGGCGCTTTGTCTCCTACAATCTTAGAGAAAGTTTTACATACT TAAGTGGGTACCACAGATAGGCATGTACCTTAAATTCAAATCTACAGTTTTACAAAATGTTTTCCTTTGTGTGCCTTTCCTATGTCAAAT TAGCCAGAAGGAAGAAGAGACGTTAAGAATGGCAGATAAATTTAACAGGTAATGATACAGAGATTGGCCATTACGCCAGCTCTCAGGAGA AAAACAACTAGGATGTCTTGAAACCCGTGCATTTAATTTTAGAAATGGCAAATTTGTAAGCGTGTCATTTAAGTAATTTGATGCTCAGTT TTAGGGTCTAAGTTGACCTCGAGTGAGCCATGCAAAAATAGCTTTAAAATTATACATGAGCAGCTCAAAGTAAACGTGTATTTTTTAGTA ACAATGAAATTGTCAAATTTCAAGATTTTAATAACAGGACAGTTCAACTAATAAACTTTATTGCATACAAGATTTATTGCAATGTGGGAA >35831_35831_2_HDAC4-CUL3_HDAC4_chr2_240048151_ENST00000541256_CUL3_chr2_225422573_ENST00000264414_length(amino acids)=1240AA_BP=494 MGCPWAVPGAVLAQMDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQ LHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISS DPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDV TDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLT LPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVTDWYLSGLGALPLHAQSLVGADRVSPSIHKLRQHRPL GRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHK HGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIR DHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERV MHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNP VDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVF ERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSA TPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNR EKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDD -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for HDAC4-CUL3 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Hgene | HDAC4 | chr2:240048151 | chr2:225422573 | ENST00000345617 | - | 12 | 27 | 118_313 | 506.0 | 1085.0 | MEF2A |
Tgene | CUL3 | chr2:240048151 | chr2:225422573 | ENST00000344951 | 0 | 15 | 2_41 | 0 | 703.0 | KLHL18 | |
Tgene | CUL3 | chr2:240048151 | chr2:225422573 | ENST00000409096 | 0 | 16 | 2_41 | 0 | 745.0 | KLHL18 | |
Tgene | CUL3 | chr2:240048151 | chr2:225422573 | ENST00000409777 | 0 | 16 | 2_41 | 0 | 745.0 | KLHL18 |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | CUL3 | chr2:240048151 | chr2:225422573 | ENST00000264414 | 0 | 16 | 2_41 | 22.0 | 769.0 | KLHL18 |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for HDAC4-CUL3 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for HDAC4-CUL3 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HDAC4 | C2931817 | Chromosome 2q37 deletion syndrome | 4 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
Hgene | HDAC4 | C0036341 | Schizophrenia | 2 | PSYGENET |
Hgene | HDAC4 | C0005684 | Malignant neoplasm of urinary bladder | 1 | CTD_human |
Hgene | HDAC4 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Hgene | HDAC4 | C0009171 | Cocaine Abuse | 1 | CTD_human |
Hgene | HDAC4 | C0011570 | Mental Depression | 1 | PSYGENET |
Hgene | HDAC4 | C0011616 | Contact Dermatitis | 1 | CTD_human |
Hgene | HDAC4 | C0020796 | Profound Mental Retardation | 1 | CTD_human |
Hgene | HDAC4 | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human |
Hgene | HDAC4 | C0162351 | Contact hypersensitivity | 1 | CTD_human |
Hgene | HDAC4 | C0221357 | Brachydactyly | 1 | CTD_human |
Hgene | HDAC4 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
Hgene | HDAC4 | C0340543 | Familial primary pulmonary hypertension | 1 | CTD_human |
Hgene | HDAC4 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Hgene | HDAC4 | C0525045 | Mood Disorders | 1 | PSYGENET |
Hgene | HDAC4 | C0600427 | Cocaine Dependence | 1 | CTD_human |
Hgene | HDAC4 | C0917816 | Mental deficiency | 1 | CTD_human |
Hgene | HDAC4 | C1862102 | BRACHYDACTYLY, TYPE E1 | 1 | CTD_human |
Hgene | HDAC4 | C1969342 | PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED | 1 | CTD_human |
Hgene | HDAC4 | C1969343 | Pulmonary Hypertension, Primary, Fenfluramine-Associated | 1 | CTD_human |
Hgene | HDAC4 | C3203102 | Idiopathic pulmonary arterial hypertension | 1 | CTD_human |
Hgene | HDAC4 | C3714756 | Intellectual Disability | 1 | CTD_human |
Hgene | HDAC4 | C3714844 | Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia | 1 | CTD_human |
Hgene | HDAC4 | C4552070 | Pulmonary Hypertension, Primary, 1 | 1 | CTD_human |
Tgene | C0025202 | melanoma | 1 | CTD_human | |
Tgene | C0033578 | Prostatic Neoplasms | 1 | CTD_human | |
Tgene | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human | |
Tgene | C1535926 | Neurodevelopmental Disorders | 1 | CTD_human | |
Tgene | C3469606 | PSEUDOHYPOALDOSTERONISM, TYPE IIE | 1 | CTD_human;GENOMICS_ENGLAND;UNIPROT |