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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:RAPGEF5-STK4 (FusionGDB2 ID:HG9771TG6789) |
Fusion Gene Summary for RAPGEF5-STK4 |
Fusion gene summary |
Fusion gene information | Fusion gene name: RAPGEF5-STK4 | Fusion gene ID: hg9771tg6789 | Hgene | Tgene | Gene symbol | RAPGEF5 | STK4 | Gene ID | 9771 | 6789 |
Gene name | Rap guanine nucleotide exchange factor 5 | serine/threonine kinase 4 | |
Synonyms | GFR|MR-GEF|REPAC | KRS2|MST1|YSK3 | |
Cytomap | ('RAPGEF5')('STK4') 7p15.3 | 20q13.12 | |
Type of gene | protein-coding | protein-coding | |
Description | rap guanine nucleotide exchange factor 5M-Ras-regulated GEFM-Ras-regulated Rap GEFRap guanine nucleotide exchange factor (GEF) 5guanine nucleotide exchange factor for Rap1related to Epac | serine/threonine-protein kinase 4STE20-like kinase MST1kinase responsive to stress 2mammalian STE20-like protein kinase 1mammalian sterile 20-like 1serine/threonine-protein kinase Krs-2 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000344041, ENST00000405243, ENST00000401957, ENST00000475788, | ||
Fusion gene scores | * DoF score | 16 X 14 X 10=2240 | 13 X 13 X 7=1183 |
# samples | 21 | 16 | |
** MAII score | log2(21/2240*10)=-3.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/1183*10)=-2.88630626345243 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RAPGEF5 [Title/Abstract] AND STK4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | RAPGEF5(22347958)-STK4(43607084), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | RAPGEF5-STK4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RAPGEF5-STK4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RAPGEF5-STK4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RAPGEF5-STK4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | STK4 | GO:0000902 | cell morphogenesis | 11805089 |
Tgene | STK4 | GO:0001934 | positive regulation of protein phosphorylation | 19962960 |
Tgene | STK4 | GO:0006468 | protein phosphorylation | 8566796|11805089 |
Tgene | STK4 | GO:0006915 | apoptotic process | 21212262 |
Tgene | STK4 | GO:0018105 | peptidyl-serine phosphorylation | 16751106 |
Tgene | STK4 | GO:0032092 | positive regulation of protein binding | 22292086 |
Tgene | STK4 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19962960 |
Tgene | STK4 | GO:0035329 | hippo signaling | 20412773 |
Tgene | STK4 | GO:0035556 | intracellular signal transduction | 8566796 |
Tgene | STK4 | GO:0043065 | positive regulation of apoptotic process | 15109305 |
Tgene | STK4 | GO:0046777 | protein autophosphorylation | 11805089 |
Tgene | STK4 | GO:0050821 | protein stabilization | 19962960 |
Fusion gene breakpoints across RAPGEF5 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across STK4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-BR-8077-01A | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
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Fusion Gene ORF analysis for RAPGEF5-STK4 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000344041 | ENST00000487587 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
5CDS-intron | ENST00000405243 | ENST00000487587 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
In-frame | ENST00000344041 | ENST00000372801 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
In-frame | ENST00000344041 | ENST00000372806 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
In-frame | ENST00000344041 | ENST00000396731 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
In-frame | ENST00000344041 | ENST00000499879 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
In-frame | ENST00000405243 | ENST00000372801 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
In-frame | ENST00000405243 | ENST00000372806 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
In-frame | ENST00000405243 | ENST00000396731 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
In-frame | ENST00000405243 | ENST00000499879 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
intron-3CDS | ENST00000401957 | ENST00000372801 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
intron-3CDS | ENST00000401957 | ENST00000372806 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
intron-3CDS | ENST00000401957 | ENST00000396731 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
intron-3CDS | ENST00000401957 | ENST00000499879 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
intron-3CDS | ENST00000475788 | ENST00000372801 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
intron-3CDS | ENST00000475788 | ENST00000372806 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
intron-3CDS | ENST00000475788 | ENST00000396731 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
intron-3CDS | ENST00000475788 | ENST00000499879 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
intron-intron | ENST00000401957 | ENST00000487587 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
intron-intron | ENST00000475788 | ENST00000487587 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000344041 | RAPGEF5 | chr7 | 22347958 | - | ENST00000372806 | STK4 | chr20 | 43607084 | + | 6665 | 534 | 1 | 1881 | 626 |
ENST00000344041 | RAPGEF5 | chr7 | 22347958 | - | ENST00000396731 | STK4 | chr20 | 43607084 | + | 1807 | 534 | 1 | 1806 | 602 |
ENST00000344041 | RAPGEF5 | chr7 | 22347958 | - | ENST00000372801 | STK4 | chr20 | 43607084 | + | 2409 | 534 | 1 | 1806 | 601 |
ENST00000344041 | RAPGEF5 | chr7 | 22347958 | - | ENST00000499879 | STK4 | chr20 | 43607084 | + | 5592 | 534 | 1 | 1716 | 571 |
ENST00000405243 | RAPGEF5 | chr7 | 22347958 | - | ENST00000372806 | STK4 | chr20 | 43607084 | + | 6895 | 764 | 9 | 2111 | 700 |
ENST00000405243 | RAPGEF5 | chr7 | 22347958 | - | ENST00000396731 | STK4 | chr20 | 43607084 | + | 2037 | 764 | 9 | 2036 | 675 |
ENST00000405243 | RAPGEF5 | chr7 | 22347958 | - | ENST00000372801 | STK4 | chr20 | 43607084 | + | 2639 | 764 | 9 | 2036 | 675 |
ENST00000405243 | RAPGEF5 | chr7 | 22347958 | - | ENST00000499879 | STK4 | chr20 | 43607084 | + | 5822 | 764 | 9 | 1946 | 645 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000344041 | ENST00000372806 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + | 0.000714862 | 0.99928516 |
ENST00000344041 | ENST00000396731 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + | 0.002865872 | 0.9971341 |
ENST00000344041 | ENST00000372801 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + | 0.001626225 | 0.99837375 |
ENST00000344041 | ENST00000499879 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + | 0.001091768 | 0.9989083 |
ENST00000405243 | ENST00000372806 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + | 0.00139482 | 0.9986052 |
ENST00000405243 | ENST00000396731 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + | 0.00786677 | 0.9921332 |
ENST00000405243 | ENST00000372801 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + | 0.004996639 | 0.9950034 |
ENST00000405243 | ENST00000499879 | RAPGEF5 | chr7 | 22347958 | - | STK4 | chr20 | 43607084 | + | 0.00227656 | 0.9977234 |
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Fusion Genomic Features for RAPGEF5-STK4 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
RAPGEF5 | chr7 | 22347957 | - | STK4 | chr20 | 43607083 | + | 4.57E-06 | 0.99999547 |
RAPGEF5 | chr7 | 22347957 | - | STK4 | chr20 | 43607083 | + | 4.57E-06 | 0.99999547 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for RAPGEF5-STK4 |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:22347958/chr20:43607084) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | STK4 | chr7:22347958 | chr20:43607084 | ENST00000372801 | 1 | 12 | 290_310 | 38 | 632.6666666666666 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | STK4 | chr7:22347958 | chr20:43607084 | ENST00000372806 | 1 | 11 | 290_310 | 38 | 488.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | STK4 | chr7:22347958 | chr20:43607084 | ENST00000396731 | 1 | 11 | 290_310 | 38 | 463.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | STK4 | chr7:22347958 | chr20:43607084 | ENST00000372801 | 1 | 12 | 373_378 | 38 | 632.6666666666666 | Compositional bias | Note=Poly-Glu | |
Tgene | STK4 | chr7:22347958 | chr20:43607084 | ENST00000372806 | 1 | 11 | 373_378 | 38 | 488.0 | Compositional bias | Note=Poly-Glu | |
Tgene | STK4 | chr7:22347958 | chr20:43607084 | ENST00000396731 | 1 | 11 | 373_378 | 38 | 463.0 | Compositional bias | Note=Poly-Glu | |
Tgene | STK4 | chr7:22347958 | chr20:43607084 | ENST00000372801 | 1 | 12 | 433_480 | 38 | 632.6666666666666 | Domain | SARAH | |
Tgene | STK4 | chr7:22347958 | chr20:43607084 | ENST00000372806 | 1 | 11 | 433_480 | 38 | 488.0 | Domain | SARAH | |
Tgene | STK4 | chr7:22347958 | chr20:43607084 | ENST00000396731 | 1 | 11 | 433_480 | 38 | 463.0 | Domain | SARAH | |
Tgene | STK4 | chr7:22347958 | chr20:43607084 | ENST00000372801 | 1 | 12 | 36_44 | 38 | 632.6666666666666 | Nucleotide binding | ATP | |
Tgene | STK4 | chr7:22347958 | chr20:43607084 | ENST00000372806 | 1 | 11 | 36_44 | 38 | 488.0 | Nucleotide binding | ATP | |
Tgene | STK4 | chr7:22347958 | chr20:43607084 | ENST00000396731 | 1 | 11 | 36_44 | 38 | 463.0 | Nucleotide binding | ATP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | RAPGEF5 | chr7:22347958 | chr20:43607084 | ENST00000401957 | - | 1 | 16 | 345_579 | 0 | 581.0 | Domain | Ras-GEF |
Hgene | RAPGEF5 | chr7:22347958 | chr20:43607084 | ENST00000401957 | - | 1 | 16 | 68_201 | 0 | 581.0 | Domain | N-terminal Ras-GEF |
Tgene | STK4 | chr7:22347958 | chr20:43607084 | ENST00000372801 | 1 | 12 | 30_281 | 38 | 632.6666666666666 | Domain | Protein kinase | |
Tgene | STK4 | chr7:22347958 | chr20:43607084 | ENST00000372806 | 1 | 11 | 30_281 | 38 | 488.0 | Domain | Protein kinase | |
Tgene | STK4 | chr7:22347958 | chr20:43607084 | ENST00000396731 | 1 | 11 | 30_281 | 38 | 463.0 | Domain | Protein kinase |
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Fusion Gene Sequence for RAPGEF5-STK4 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>72253_72253_1_RAPGEF5-STK4_RAPGEF5_chr7_22347958_ENST00000344041_STK4_chr20_43607084_ENST00000372801_length(transcript)=2409nt_BP=534nt GCTGCGGCCGCGGCTGAGGGACCTGCCCGCGCTGCTGCGGAGCGGGCTCACGCTGCGGAGGAAGCGGAGCGCCGCTGGGGGCCGGACTCT ATCAAGAAGAATATCTAATCCGTACCTTGAACATACGCCTTCCCAGATTTATGGAGAGAATTCTTCTTGTGCAGGAAGAGCATTGAGGAA TATTATTATCGTTCAAGCAGCTGACCTGATAAAGGACAGAGTGAACCTCAAGGGGTTTTACAGGAGGAGCTGCGTTGGGTCAGAGCTGGT AGACTGGCTTCTAGAACACTGTCCTTTCGTCCAGTGCAGATCTATGGCCATAGGAGTCTGGCAACTCCTACTGGACATGGGAATTATGTT ATCAGTGGACCAGCATCTATACTTTCAAGATACTTATGTTTTCTACCAGTTTTCCTCTGATGAATGTAGCTACTTGTACTGTGAATTTGA AAGAGAAGAAGAATGGCAAAATGGTGTCAAGCTTTTACTGCAACTTGTGCCTCTCATTCCTGCCAGAGGTGGCATCTGTGAACTGTCCTA TGGCAGCGTATACAAAGCTATTCATAAAGAGACCGGCCAGATTGTTGCTATTAAGCAAGTTCCTGTGGAATCAGACCTCCAGGAGATAAT CAAAGAAATCTCTATAATGCAGCAATGTGACAGCCCTCATGTAGTCAAATATTATGGCAGTTATTTTAAGAACACAGACTTATGGATCGT TATGGAGTACTGTGGGGCTGGTTCTGTATCTGATATCATTCGATTACGAAATAAAACGTTAACAGAAGATGAAATAGCTACAATATTACA ATCAACTCTTAAGGGACTTGAATACCTTCATTTTATGAGAAAAATACACCGAGATATCAAGGCAGGAAATATTTTGCTAAATACAGAAGG ACATGCAAAACTTGCAGATTTTGGGGTAGCAGGTCAACTTACAGATACCATGGCCAAGCGGAATACAGTGATAGGAACACCATTTTGGAT GGCTCCAGAAGTGATTCAGGAAATTGGATACAACTGTGTAGCAGACATCTGGTCCCTGGGAATAACTGCCATAGAAATGGCTGAAGGAAA GCCCCCTTATGCTGATATCCATCCAATGAGGGCAATCTTCATGATTCCTACAAATCCTCCTCCCACATTCCGAAAACCAGAGCTATGGTC AGATAACTTTACAGATTTTGTGAAACAGTGTCTTGTAAAGAGCCCTGAGCAGAGGGCCACAGCCACTCAGCTCCTGCAGCACCCATTTGT CAGGAGTGCCAAAGGAGTGTCAATACTGCGAGACTTAATTAATGAAGCCATGGATGTGAAACTGAAACGCCAGGAATCCCAGCAGCGGGA AGTGGACCAGGACGATGAAGAAAACTCAGAAGAGGATGAAATGGATTCTGGCACGATGGTTCGAGCAGTGGGTGATGAGATGGGCACTGT CCGAGTAGCCAGCACCATGACTGATGGAGCCAATACTATGATTGAGCACGATGACACGTTGCCATCACAACTGGGCACCATGGTGATCAA TGCAGAGGATGAGGAAGAGGAAGGAACTATGAAAAGAAGGGATGAGACCATGCAGCCTGCGAAACCATCCTTTCTTGAATATTTTGAACA AAAAGAAAAGGAAAACCAGATCAACAGCTTTGGCAAGAGTGTACCTGGTCCACTGAAAAATTCTTCAGATTGGAAAATACCACAGGATGG AGACTACGAGTTTAAAACTAGCCAAGAACAGCAGTCTGGAAAAGACATATGTATCCAAAATTGCCAGGGAAACCTGCTGTGTAGATACGC TTTCTGAGAAACCACATGCTTAAGAGTTGGACAGTGGAGGACCTTCAGAAGAGGCTCTTGGCCCTGGACCCCATGATGGAGCAGGAGATT GAAGAGATCCGGCAGAAGTACCAGTCCAAGCGGCAGCCCATCCTGGATGCCATAGAGGCTAAGAAGAGACGGCAACAAAACTTCTGAGCA AGGCCAGGCTGTGAGGGCCCCAGCTCCACCCAGGCTTTGGGTGAATTCTGGATGGCTTGCCTCATGTTTGTTAGCCAGCACTTCTGCTCT GTCGTCTCTCCACAGCACCTTTGTGAACTCAGGAATGTGCGCCAGTGGGAAGGGCTCTCTTGACAGTCAGCGTGCCATCTTGATGTGTGT ATGTACATTGGTCAGGTATATTATCTCAAAGGATTTATATTGGCGCTTTTAACTCAGAGTTTTAAACCCCAGGAACAGAGACTCCTAGTT GAGTGATAGCTGGGAAAGTTTTACATTGTCTGTTTTTCTTCTCCCAATAGCTTTCAATTGTTCTTTCTGGAAGACTTTTAAAAAAATATA >72253_72253_1_RAPGEF5-STK4_RAPGEF5_chr7_22347958_ENST00000344041_STK4_chr20_43607084_ENST00000372801_length(amino acids)=601AA_BP=178 LRPRLRDLPALLRSGLTLRRKRSAAGGRTLSRRISNPYLEHTPSQIYGENSSCAGRALRNIIIVQAADLIKDRVNLKGFYRRSCVGSELV DWLLEHCPFVQCRSMAIGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDECSYLYCEFEREEEWQNGVKLLLQLVPLIPARGGICELSY GSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQ STLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGK PPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQRE VDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQ -------------------------------------------------------------- >72253_72253_2_RAPGEF5-STK4_RAPGEF5_chr7_22347958_ENST00000344041_STK4_chr20_43607084_ENST00000372806_length(transcript)=6665nt_BP=534nt GCTGCGGCCGCGGCTGAGGGACCTGCCCGCGCTGCTGCGGAGCGGGCTCACGCTGCGGAGGAAGCGGAGCGCCGCTGGGGGCCGGACTCT ATCAAGAAGAATATCTAATCCGTACCTTGAACATACGCCTTCCCAGATTTATGGAGAGAATTCTTCTTGTGCAGGAAGAGCATTGAGGAA TATTATTATCGTTCAAGCAGCTGACCTGATAAAGGACAGAGTGAACCTCAAGGGGTTTTACAGGAGGAGCTGCGTTGGGTCAGAGCTGGT AGACTGGCTTCTAGAACACTGTCCTTTCGTCCAGTGCAGATCTATGGCCATAGGAGTCTGGCAACTCCTACTGGACATGGGAATTATGTT ATCAGTGGACCAGCATCTATACTTTCAAGATACTTATGTTTTCTACCAGTTTTCCTCTGATGAATGTAGCTACTTGTACTGTGAATTTGA AAGAGAAGAAGAATGGCAAAATGGTGTCAAGCTTTTACTGCAACTTGTGCCTCTCATTCCTGCCAGAGGTGGCATCTGTGAACTGTCCTA TGGCAGCGTATACAAAGCTATTCATAAAGAGACCGGCCAGATTGTTGCTATTAAGCAAGTTCCTGTGGAATCAGACCTCCAGGAGATAAT CAAAGAAATCTCTATAATGCAGCAATGTGACAGCCCTCATGTAGTCAAATATTATGGCAGTTATTTTAAGAACACAGACTTATGGATCGT TATGGAGTACTGTGGGGCTGGTTCTGTATCTGATATCATTCGATTACGAAATAAAACGTTAACAGAAGATGAAATAGCTACAATATTACA ATCAACTCTTAAGGGACTTGAATACCTTCATTTTATGAGAAAAATACACCGAGATATCAAGGCAGGAAATATTTTGCTAAATACAGAAGG ACATGCAAAACTTGCAGATTTTGGGGTAGCAGGTCAACTTACAGATACCATGGCCAAGCGGAATACAGTGATAGGAACACCATTTTGGAT GGCTCCAGAAGTGATTCAGGAAATTGGATACAACTGTGTAGCAGACATCTGGTCCCTGGGAATAACTGCCATAGAAATGGCTGAAGGAAA GCCCCCTTATGCTGATATCCATCCAATGAGGGCAATCTTCATGATTCCTACAAATCCTCCTCCCACATTCCGAAAACCAGAGCTATGGTC AGATAACTTTACAGATTTTGTGAAACAGTGTCTTGTAAAGAGCCCTGAGCAGAGGGCCACAGCCACTCAGCTCCTGCAGCACCCATTTGT CAGGAGTGCCAAAGGAGTGTCAATACTGCGAGACTTAATTAATGAAGCCATGGATGTGAAACTGAAACGCCAGGAATCCCAGCAGCGGGA AGTGGACCAGGACGATGAAGAAAACTCAGAAGAGGATGAAATGGATTCTGGCACGATGGTTCGAGCAGTGGGTGATGAGATGGGCACTGT CCGAGTAGCCAGCACCATGACTGATGGAGCCAATACTATGATTGAGCACGATGACACGTTGCCATCACAACTGGGCACCATGGTGATCAA TGCAGAGGATGAGGAAGAGGAAGGAACTATGAAAAGAAGGGATGAGACCATGCAGCCTGCGAAACCATCCTTTCTTGAATATTTTGAACA AAAAGAAAAGGAAAACCAGATCAACAGCTTTGGCAAGAGTGTACCTGGTCCACTGAAAAATTCTTCAGATTGGAAAATACCACAGGATGG AGACTACGAGTTTCTTAAGAGTTGGACAGTGGAGGACCTTCAGAAGAGGCTCTTGGCCCTGGACCCCATGATGGAGCAGGAGATTGAAGA GATCCGGCAGAAGTACCAGTCCAAGCGGCAGCCCATCCTGGATGCCATAGAGGCTAAGAAGAGACGGCAACAAAACTTCTGAGCAAGGCC AGGCTGTGAGGGCCCCAGCTCCACCCAGGCTTTGGGTGAATTCTGGATGGCTTGCCTCATGTTTGTTAGCCAGCACTTCTGCTCTGTCGT CTCTCCACAGCACCTTTGTGAACTCAGGAATGTGCGCCAGTGGGAAGGGCTCTCTTGACAGTCAGCGTGCCATCTTGATGTGTGTATGTA CATTGGTCAGGTATATTATCTCAAAGGATTTATATTGGCGCTTTTAACTCAGAGTTTTAAACCCCAGGAACAGAGACTCCTAGTTGAGTG ATAGCTGGGAAAGTTTTACATTGTCTGTTTTTCTTCTCCCAATAGCTTTCAATTGTTCTTTCTGGAAGACTTTTAAAAAAATATAAATAT GCATATATATATATAAATTATAAATAGATTCCCCACGCAGTGTGGTGGCATCTCTGTACAGGTACAGTTTTAAACGGTTTGCCTCTTTTC TGTAAGATTATGGTACTGTGGAACATGAGGGCAGAGGACACCGGGAGGCTGTTAGGGGGTCACTGAATCCCAGGAGCCAACCTCCCCCTT TGCAGGGCTGCATTTAAAAATTAGGTTTGGGACAGTTCTTGTACCGTGGTTTCAGCCTTGTGTGGTCATCACTGGCTTCTGGAGCTATTG GTGATGTCCAAGGGAAAGCTTTGAGAGTTTATGTTTACTCTTTGAGTCCCAGGAGAAGCCTGGCACCCTCTTTGCAAATTGGCCTTTGCT CTTTCAATGCCTTTCATCCATCTCCACTCTCTCAACTGCCTAAAGTCACAGCACAGATACTGCCCAGTGCCTTAAGAGGAGACATGATCT CTACCAGGGACTCTCAGCAAACACGGGACTGTGTTCAGTCCACAAAGGAAAAGCGTTTTTGAAGCTCTCATTGTTCATGTAAAAATCATA CACGTGGCATGTTGCTCCACATTCCTTACACACAGGGGTAGAGGGGATTGCTTTTGTGACCCACGTTCAAATATGTGACTGTTTTCTTTT CTCTTTTACTGCTAAGCAGCCTGGAAAGGATAAATGAATATTAGACTAAGATTTGTTTTCCAGGAGGCTCAATCTGAACACACAGAATGT CAGAGCTGGAAGGGACTATAGAGATCATCTGATCTGATCCTCTTGTACGGATGATCGCAAAACTGAGGTGTAGAGAGGGGAATGGCCAAA ATCACAAAGCAAGTTAGCGTTAAGAGCTGAGACTAGAATTCAGGGTCCTCACTCCCAGGCCACCGAACCATGCAGCCCCTTCTTTGGGGG AAGAGACCTGTGTCAGTCTTGGTTAATTGTTCCAGGGAACCTTGCTAACAGAAACTTGCTCTTGCCTTGGCTCTTCAGTAGATGACCTGG CTGTAAAGAGATTCCCTGGACGAGCCAGATCATTCAGTTTCAGCGAGTCCTTGAGCTCCACAACATCTACCAGATATAGCAGACAAGCAC CCATGGAGGCAGGTTTCGGGCCTGAAGCAGATCAGAGGGCTTTGCAAAAGACAGCATAGAGCCATCTTCCTGCAACTTTACCTCTTTCCC TCAGATGGGGAGCCATGACTGGGTTGCACCTCAGGATACTGTAATTTGACTCCATAATTGCTTTTGCTCCTGAAACCTGGGAATCAATGG AAAGGCAGGGAATGTGCCTCTTCTGTGGCCAGATTCTGTTATTTGCAATTAAAGCAAGTTTTTAAAAAATGCAAGAGGCAGTTGTTAGTC TTCAGGGCTTGGCAACTGAAATAGCTATGTGGCGGATACGGAAAACAGAGGACAATTTGAGGATCTTGCTGGAATAATAAATGACAGCTA CCATTTGTTGAGCACCTATTATATATCAGGCACTGAGCTGGGTAGGCTCTAAACTTCACAATAACCCTGTGACTTAACTACTTTATCTCC ATTTTGTAGTTGAAGAAATAAGTTCAGAGAGAAAGATTCCTTCCCAAGGTCATGCAGCTAGTAAATGATAGAATCAGGATTCATAGCATC ACTATAGGGGGTCAATATTTACACAAAAAAGGAAAGTCACAAGCCTGTTTAAAATGAAGTGACCACCTTTTCTTGCATAGACTAAATAAC TCGAACTGGCATTTTTAGGTTGGAAAGACAGCTGAATTAGTAGTTAAGTCTGATAGCCAAGTAAGTTTTAAAAACCAAAGCATCCAGGAT GCACACCCCTGCACCATTTGCTGTGCGAATTAATAGTTCTGTCTCTCTCTCTCTTTCTTTTTTCTTTTTATTCTTTGAGATGGATTTTCG CTCTTGTCGCCCAGGCTGGAGTACAATGGCACGATCTTGGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGCGATTCTTCTGCTGGGATT ACAGCATATGCCACCATGCCCAGATTATTTTTTTGTATTTGTAGTAGAGACGGGGTTTCACCATGTCAGTCAGGCTGGTCTTGAACTCCT GACCTCAGGTGATCCACCCGCCTCAGCCTCCCACACTGCTGGGATTACAGGCATGAGCCACCGCTCCTGGCCTCTCTTTCTTTTTTAAAC AAAGAACTTTGCACTTGGCCAGAGAGGAGGAGAAAGCCCATTTTCTCCCTTCCTAAGCTAGATCCAAATAAAAGAAAGTTCAGTTTTCCC CCATAACTATTCTTGGGTCATGAACTTTGATCTGGAGTTTGTTTTGTTTCAGGAATGTGTGCACCCAGCTTGCTGATCCAACAAAGTCTA TTGCTTACCAGTCTAGCTTGATGAAGCCTTTTGGCCAGAAGTCAATTTGTTTTGGATCAGAGAAATTTCCTGACAAGGTATATTTGTTTT CTAGTGACAGAAAGGCAAAGGAACAAGTCCTAGTTGTTGTTGTTGTTGTTGAATACTAAATTTAAGATATGTCAGCTTGCTTTCAATGAG CCTTGGGCTTCTGTTATTGCTTGAGCATTTGGAACTCGAGCTTCCAGAGAAATTTGAGGTCCTCGCTTGTTCTCTGCCTTCAAGAAACAA TGACCTGATTCTGTCTTTAAAAAAAAAAATCTCAGAATTCTTTTTTTGTTTGTGTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTT GCCCAGGCTGGAGTGCAGTGGCGCCATCTCGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAGGT AGCTGCCACTACAGGTGCTGCACCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATATTAGCCAGGTGGGTC TTGAACTCCTGACCTTGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCTTGCCTGGCCAAAAATCTCA GAATTCTTTAAGACTGTTTTAATTGCTCCATCAGTAATTTTGAAGCACTTTCCTTTTTTTTTTTTTTTCCCCTTTTTGTCCCTTTCCCCA AGCCACCAATTGGATGGATGAATGTTTGACGGGGAAGAGGAAGGGTAGGAGGATGCATGGATGAGTGGATGAGTGGATCGATGGATGTAT TGATAAATAGATAGAACCAGTCATCTGAAGCAACTTAAGAATTGTAGCCTTGACTCCTTGAGACTGTAGATTTCGATCCAGGAAACATTT ATTTAGCACCTGCCAGATGCCAGAAATTTATACCATTTAAAACTCAGTAAGTCTTTTAAATATCAGGAAGGAGAGAAGCGACATCATGAT ACATCCTATGGGTATTAAAAAGCCAATAGAATATTATGAATAATTTTATGCTAATAAATTTAACAACTTCAACATCATAAACAAATTCCT TGAAAAATAAAAAGTACCAAAATTCATTCAAGAAGAAATAGATACCAGCCTGAGCAACATGGCAAAATCCCATCTCTACAAAACATCAAA AAAAAAAAAAATTAGTCGGGCATGGTGGTGCACACCTGTAATCCCAGCTTGTCAGGAGGCTGAAGTGGGAGGATCACCTGAGCCCAGGGA GGTCAAGGATGCAGTGAGCCATGGTCTCACCACTGCACTCTAGCCTGGGTGACAGAATGAGACCCCGTCTCAAAAAAAAAGAAGAAGTAG ATAATCTGAATAGCCCTATATCTATAGAAACTTAATAGTGCTGGGAGATATAGGTATTATTATCCTCATTTTACAGATGTGAAAATTGAG GCTCAGAGAAGTAAAGTCTATTGCTCAAGGTCATGTGGCTAGAATATGGCAGAGCCATGATTCAGATCCAGGTCTTCTGATTCTTATTCC AGTGTCCTTTCTAGCATACCATGTTGCCTCTAAAGATTGCAGCTCCTTATTTACTAGAAAATTGTTCCTGCCCAATCTACATCTCCACCT CACCCCATCTTTTCTTAAGCACTATGTTTGTGTTTTTATCAGTATTATATTCATTGTCTTTGGAATACATGTTCTTGTTTGTGTTTGGAA AAAAAATCTCTTTTACCAGCTTGCACTCGGACCAACTTGGAAAAAAAAAAGCTTAAATGTTTTTGCTATGTACAGTTTAAAAATGTGAAG TTTGTAGCTTTAACTTTTTGTAAGAAAATCTAATAACACTGGCTTAAGTGCTGACTTGAAATGCTATTTTGTAAGGTTTGGATGTAAGTA ATCAATTGAGGTCAGCAGTTTGTATGAGACATAGCTTCCTCCATTGCCCCCACTCCTTTTTTCTTTTTTAAGTTTGAGATGCTTCCTGTG TTTTTATGTTAGAATTGTTGTTCTCCTTCTTTTCTTCTTCCTATACCTCATCACGTTTGTTTTAAATAAACTGTCCTTTGGACCACAAAC >72253_72253_2_RAPGEF5-STK4_RAPGEF5_chr7_22347958_ENST00000344041_STK4_chr20_43607084_ENST00000372806_length(amino acids)=626AA_BP=178 LRPRLRDLPALLRSGLTLRRKRSAAGGRTLSRRISNPYLEHTPSQIYGENSSCAGRALRNIIIVQAADLIKDRVNLKGFYRRSCVGSELV DWLLEHCPFVQCRSMAIGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDECSYLYCEFEREEEWQNGVKLLLQLVPLIPARGGICELSY GSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQ STLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGK PPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQRE VDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQ -------------------------------------------------------------- >72253_72253_3_RAPGEF5-STK4_RAPGEF5_chr7_22347958_ENST00000344041_STK4_chr20_43607084_ENST00000396731_length(transcript)=1807nt_BP=534nt GCTGCGGCCGCGGCTGAGGGACCTGCCCGCGCTGCTGCGGAGCGGGCTCACGCTGCGGAGGAAGCGGAGCGCCGCTGGGGGCCGGACTCT ATCAAGAAGAATATCTAATCCGTACCTTGAACATACGCCTTCCCAGATTTATGGAGAGAATTCTTCTTGTGCAGGAAGAGCATTGAGGAA TATTATTATCGTTCAAGCAGCTGACCTGATAAAGGACAGAGTGAACCTCAAGGGGTTTTACAGGAGGAGCTGCGTTGGGTCAGAGCTGGT AGACTGGCTTCTAGAACACTGTCCTTTCGTCCAGTGCAGATCTATGGCCATAGGAGTCTGGCAACTCCTACTGGACATGGGAATTATGTT ATCAGTGGACCAGCATCTATACTTTCAAGATACTTATGTTTTCTACCAGTTTTCCTCTGATGAATGTAGCTACTTGTACTGTGAATTTGA AAGAGAAGAAGAATGGCAAAATGGTGTCAAGCTTTTACTGCAACTTGTGCCTCTCATTCCTGCCAGAGGTGGCATCTGTGAACTGTCCTA TGGCAGCGTATACAAAGCTATTCATAAAGAGACCGGCCAGATTGTTGCTATTAAGCAAGTTCCTGTGGAATCAGACCTCCAGGAGATAAT CAAAGAAATCTCTATAATGCAGCAATGTGACAGCCCTCATGTAGTCAAATATTATGGCAGTTATTTTAAGAACACAGACTTATGGATCGT TATGGAGTACTGTGGGGCTGGTTCTGTATCTGATATCATTCGATTACGAAATAAAACGTTAACAGAAGATGAAATAGCTACAATATTACA ATCAACTCTTAAGGGACTTGAATACCTTCATTTTATGAGAAAAATACACCGAGATATCAAGGCAGGAAATATTTTGCTAAATACAGAAGG ACATGCAAAACTTGCAGATTTTGGGGTAGCAGGTCAACTTACAGATACCATGGCCAAGCGGAATACAGTGATAGGAACACCATTTTGGAT GGCTCCAGAAGTGATTCAGGAAATTGGATACAACTGTGTAGCAGACATCTGGTCCCTGGGAATAACTGCCATAGAAATGGCTGAAGGAAA GCCCCCTTATGCTGATATCCATCCAATGAGGGCAATCTTCATGATTCCTACAAATCCTCCTCCCACATTCCGAAAACCAGAGCTATGGTC AGATAACTTTACAGATTTTGTGAAACAGTGTCTTGTAAAGAGCCCTGAGCAGAGGGCCACAGCCACTCAGCTCCTGCAGCACCCATTTGT CAGGAGTGCCAAAGGAGTGTCAATACTGCGAGACTTAATTAATGAAGCCATGGATGTGAAACTGAAACGCCAGGAATCCCAGCAGCGGGA AGTGGACCAGGACGATGAAGAAAACTCAGAAGAGGATGAAATGGATTCTGGCACGATGGTTCGAGCAGTGGGTGATGAGATGGGCACTGT CCGAGTAGCCAGCACCATGACTGATGGAGCCAATACTATGATTGAGCACGATGACACGTTGCCATCACAACTGGGCACCATGGTGATCAA TGCAGAGGATGAGGAAGAGGAAGGAACTATGAAAAGAAGGGATGAGACCATGCAGCCTGCGAAACCATCCTTTCTTGAATATTTTGAACA AAAAGAAAAGGAAAACCAGATCAACAGCTTTGGCAAGAGTGTACCTGGTCCACTGAAAAATTCTTCAGATTGGAAAATACCACAGGATGG AGACTACGAGTTTAAAACTAGCCAAGAACAGCAGTCTGGAAAAGACATATGTATCCAAAATTGCCAGGGAAACCTGCTGTGTAGATACGC >72253_72253_3_RAPGEF5-STK4_RAPGEF5_chr7_22347958_ENST00000344041_STK4_chr20_43607084_ENST00000396731_length(amino acids)=602AA_BP=178 LRPRLRDLPALLRSGLTLRRKRSAAGGRTLSRRISNPYLEHTPSQIYGENSSCAGRALRNIIIVQAADLIKDRVNLKGFYRRSCVGSELV DWLLEHCPFVQCRSMAIGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDECSYLYCEFEREEEWQNGVKLLLQLVPLIPARGGICELSY GSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQ STLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGK PPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQRE VDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQ -------------------------------------------------------------- >72253_72253_4_RAPGEF5-STK4_RAPGEF5_chr7_22347958_ENST00000344041_STK4_chr20_43607084_ENST00000499879_length(transcript)=5592nt_BP=534nt GCTGCGGCCGCGGCTGAGGGACCTGCCCGCGCTGCTGCGGAGCGGGCTCACGCTGCGGAGGAAGCGGAGCGCCGCTGGGGGCCGGACTCT ATCAAGAAGAATATCTAATCCGTACCTTGAACATACGCCTTCCCAGATTTATGGAGAGAATTCTTCTTGTGCAGGAAGAGCATTGAGGAA TATTATTATCGTTCAAGCAGCTGACCTGATAAAGGACAGAGTGAACCTCAAGGGGTTTTACAGGAGGAGCTGCGTTGGGTCAGAGCTGGT AGACTGGCTTCTAGAACACTGTCCTTTCGTCCAGTGCAGATCTATGGCCATAGGAGTCTGGCAACTCCTACTGGACATGGGAATTATGTT ATCAGTGGACCAGCATCTATACTTTCAAGATACTTATGTTTTCTACCAGTTTTCCTCTGATGAATGTAGCTACTTGTACTGTGAATTTGA AAGAGAAGAAGAATGGCAAAATGGTGTCAAGCTTTTACTGCAACTTGTGCCTCTCATTCCTGCCAGAGGTGGCATCTGTGAACTGTCCTA TGGCAGCGTATACAAAGCTATTCATAAAGAGACCGGCCAGATTGTTGCTATTAAGCAAGTTCCTGTGGAATCAGACCTCCAGGAGATAAT CAAAGAAATCTCTATAATGCAGCAATGTGACAGCCCTCATGTAGTCAAATATTATGGCAGTTATTTTAAGAACACAGACTTATGGATCGT TATGGAGTACTGTGGGGCTGGTTCTGTATCTGATATCATTCGATTACGAAATAAAACGGATACCATGGCCAAGCGGAATACAGTGATAGG AACACCATTTTGGATGGCTCCAGAAGTGATTCAGGAAATTGGATACAACTGTGTAGCAGACATCTGGTCCCTGGGAATAACTGCCATAGA AATGGCTGAAGGAAAGCCCCCTTATGCTGATATCCATCCAATGAGGGCAATCTTCATGATTCCTACAAATCCTCCTCCCACATTCCGAAA ACCAGAGCTATGGTCAGATAACTTTACAGATTTTGTGAAACAGTGTCTTGTAAAGAGCCCTGAGCAGAGGGCCACAGCCACTCAGCTCCT GCAGCACCCATTTGTCAGGAGTGCCAAAGGAGTGTCAATACTGCGAGACTTAATTAATGAAGCCATGGATGTGAAACTGAAACGCCAGGA ATCCCAGCAGCGGGAAGTGGACCAGGACGATGAAGAAAACTCAGAAGAGGATGAAATGGATTCTGGCACGATGGTTCGAGCAGTGGGTGA TGAGATGGGCACTGTCCGAGTAGCCAGCACCATGACTGATGGAGCCAATACTATGATTGAGCACGATGACACGTTGCCATCACAACTGGG CACCATGGTGATCAATGCAGAGGATGAGGAAGAGGAAGGAACTATGAAAAGAAGGGATGAGACCATGCAGCCTGCGAAACCATCCTTTCT TGAATATTTTGAACAAAAAGAAAAGGAAAACCAGATCAACAGCTTTGGCAAGAGTGTACCTGGTCCACTGAAAAATTCTTCAGATTGGAA AATACCACAGGATGGAGACTACGAGTTTCTTAAGAGTTGGACAGTGGAGGACCTTCAGAAGAGGCTCTTGGCCCTGGACCCCATGATGGA GCAGGAGATTGAAGAGATCCGGCAGAAGTACCAGTCCAAGCGGCAGCCCATCCTGGATGCCATAGAGGCTAAGAAGAGACGGCAACAAAA CTTCTGAGCAAGGCCAGGCTGTGAGGGCCCCAGCTCCACCCAGGCTTTGGGTGAATTCTGGATGGCTTGCCTCATGTTTGTTAGCCAGCA CTTCTGCTCTGTCGTCTCTCCACAGCACCTTTGTGAACTCAGGAATGTGCGCCAGTGGGAAGGGCTCTCTTGACAGTCAGCGTGCCATCT TGATGTGTGTATGTACATTGGTCAGGTATATTATCTCAAAGGATTTATATTGGCGCTTTTAACTCAGAGTTTTAAACCCCAGGAACAGAG ACTCCTAGTTGAGTGATAGCTGGGAAAGTTTTACATTGTCTGTTTTTCTTCTCCCAATAGCTTTCAATTGTTCTTTCTGGAAGACTTTTA AAAAAATATAAATATGCATATATATATATAAATTATAAATAGATTCCCCACGCAGTGTGGTGGCATCTCTGTACAGGTACAGTTTTAAAC GGTTTGCCTCTTTTCTGTAAGATTATGGTACTGTGGAACATGAGGGCAGAGGACACCGGGAGGCTGTTAGGGGGTCACTGAATCCCAGGA GCCAACCTCCCCCTTTGCAGGGCTGCATTTAAAAATTAGGTTTGGGACAGTTCTTGTACCGTGGTTTCAGCCTTGTGTGGTCATCACTGG CTTCTGGAGCTATTGGTGATGTCCAAGGGAAAGCTTTGAGAGTTTATGTTTACTCTTTGAGTCCCAGGAGAAGCCTGGCACCCTCTTTGC AAATTGGCCTTTGCTCTTTCAATGCCTTTCATCCATCTCCACTCTCTCAACTGCCTAAAGTCACAGCACAGATACTGCCCAGTGCCTTAA GAGGAGACATGATCTCTACCAGGGACTCTCAGCAAACACGGGACTGTGTTCAGTCCACAAAGGAAAAGCGTTTTTGAAGCTCTCATTGTT CATGTAAAAATCATACACGTGGCATGTTGCTCCACATTCCTTACACACAGGGGTAGAGGGGATTGCTTTTGTGACCCACGTTCAAATATG TGACTGTTTTCTTTTCTCTTTTACTGCTAAGCAGCCTGGAAAGGATAAATGAATATTAGACTAAGATTTGTTTTCCAGGAGGCTCAATCT GAACACACAGAATGTCAGAGCTGGAAGGGACTATAGAGATCATCTGATCTGATCCTCTTGTACGGATGATCGCAAAACTGAGGTGTAGAG AGGGGAATGGCCAAAATCACAAAGCAAGTTAGCGTTAAGAGCTGAGACTAGAATTCAGGGTCCTCACTCCCAGGCCACCGAACCATGCAG CCCCTTCTTTGGGGGAAGAGACCTGTGTCAGTCTTGGTTAATTGTTCCAGGGAACCTTGCTAACAGAAACTTGCTCTTGCCTTGGCTCTT CAGTAGATGACCTGGCTGTAAAGAGATTCCCTGGACGAGCCAGATCATTCAGTTTCAGCGAGTCCTTGAGCTCCACAACATCTACCAGAT ATAGCAGACAAGCACCCATGGAGGCAGGTTTCGGGCCTGAAGCAGATCAGAGGGCTTTGCAAAAGACAGCATAGAGCCATCTTCCTGCAA CTTTACCTCTTTCCCTCAGATGGGGAGCCATGACTGGGTTGCACCTCAGGATACTGTAATTTGACTCCATAATTGCTTTTGCTCCTGAAA CCTGGGAATCAATGGAAAGGCAGGGAATGTGCCTCTTCTGTGGCCAGATTCTGTTATTTGCAATTAAAGCAAGTTTTTAAAAAATGCAAG AGGCAGTTGTTAGTCTTCAGGGCTTGGCAACTGAAATAGCTATGTGGCGGATACGGAAAACAGAGGACAATTTGAGGATCTTGCTGGAAT AATAAATGACAGCTACCATTTGTTGAGCACCTATTATATATCAGGCACTGAGCTGGGTAGGCTCTAAACTTCACAATAACCCTGTGACTT AACTACTTTATCTCCATTTTGTAGTTGAAGAAATAAGTTCAGAGAGAAAGATTCCTTCCCAAGGTCATGCAGCTAGTAAATGATAGAATC AGGATTCATAGCATCACTATAGGGGGTCAATATTTACACAAAAAAGGAAAGTCACAAGCCTGTTTAAAATGAAGTGACCACCTTTTCTTG CATAGACTAAATAACTCGAACTGGCATTTTTAGGTTGGAAAGACAGCTGAATTAGTAGTTAAGTCTGATAGCCAAGTAAGTTTTAAAAAC CAAAGCATCCAGGATGCACACCCCTGCACCATTTGCTGTGCGAATTAATAGTTCTGTCTCTCTCTCTCTTTCTTTTTTCTTTTTATTCTT TGAGATGGATTTTCGCTCTTGTCGCCCAGGCTGGAGTACAATGGCACGATCTTGGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGCGAT TCTTCTGCTGGGATTACAGCATATGCCACCATGCCCAGATTATTTTTTTGTATTTGTAGTAGAGACGGGGTTTCACCATGTCAGTCAGGC TGGTCTTGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCCACACTGCTGGGATTACAGGCATGAGCCACCGCTCCTGGCCTCT CTTTCTTTTTTAAACAAAGAACTTTGCACTTGGCCAGAGAGGAGGAGAAAGCCCATTTTCTCCCTTCCTAAGCTAGATCCAAATAAAAGA AAGTTCAGTTTTCCCCCATAACTATTCTTGGGTCATGAACTTTGATCTGGAGTTTGTTTTGTTTCAGGAATGTGTGCACCCAGCTTGCTG ATCCAACAAAGTCTATTGCTTACCAGTCTAGCTTGATGAAGCCTTTTGGCCAGAAGTCAATTTGTTTTGGATCAGAGAAATTTCCTGACA AGGTATATTTGTTTTCTAGTGACAGAAAGGCAAAGGAACAAGTCCTAGTTGTTGTTGTTGTTGTTGAATACTAAATTTAAGATATGTCAG CTTGCTTTCAATGAGCCTTGGGCTTCTGTTATTGCTTGAGCATTTGGAACTCGAGCTTCCAGAGAAATTTGAGGTCCTCGCTTGTTCTCT GCCTTCAAGAAACAATGACCTGATTCTGTCTTTAAAAAAAAAAATCTCAGAATTCTTTTTTTGTTTGTGTTTTTTTTTTTTTTTGAGACA GAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCCATCTCGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGC CTCAGCCTCCCAGGTAGCTGCCACTACAGGTGCTGCACCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATA TTAGCCAGGTGGGTCTTGAACTCCTGACCTTGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCTTGCC TGGCCAAAAATCTCAGAATTCTTTAAGACTGTTTTAATTGCTCCATCAGTAATTTTGAAGCACTTTCCTTTTTTTTTTTTTTTCCCCTTT TTGTCCCTTTCCCCAAGCCACCAATTGGATGGATGAATGTTTGACGGGGAAGAGGAAGGGTAGGAGGATGCATGGATGAGTGGATGAGTG GATCGATGGATGTATTGATAAATAGATAGAACCAGTCATCTGAAGCAACTTAAGAATTGTAGCCTTGACTCCTTGAGACTGTAGATTTCG ATCCAGGAAACATTTATTTAGCACCTGCCAGATGCCAGAAATTTATACCATTTAAAACTCAGTAAGTCTTTTAAATATCAGGAAGGAGAG AAGCGACATCATGATACATCCTATGGGTATTAAAAAGCCAATAGAATATTATGAATAATTTTATGCTAATAAATTTAACAACTTCAACAT CATAAACAAATTCCTTGAAAAATAAAAAGTACCAAAATTCATTCAAGAAGAAATAGATACCAGCCTGAGCAACATGGCAAAATCCCATCT >72253_72253_4_RAPGEF5-STK4_RAPGEF5_chr7_22347958_ENST00000344041_STK4_chr20_43607084_ENST00000499879_length(amino acids)=571AA_BP=178 LRPRLRDLPALLRSGLTLRRKRSAAGGRTLSRRISNPYLEHTPSQIYGENSSCAGRALRNIIIVQAADLIKDRVNLKGFYRRSCVGSELV DWLLEHCPFVQCRSMAIGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDECSYLYCEFEREEEWQNGVKLLLQLVPLIPARGGICELSY GSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTDTMAKRNTVIG TPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLL QHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLG TMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMME -------------------------------------------------------------- >72253_72253_5_RAPGEF5-STK4_RAPGEF5_chr7_22347958_ENST00000405243_STK4_chr20_43607084_ENST00000372801_length(transcript)=2639nt_BP=764nt TCTCGCTTCCTGGCGAAGGCGCGGACGGCGCGCGGAGGCGAGCGCGGTGGAGAGGAGCCCCCGGCGCCGCAGCGCCGTCAGGGCATGAGG ATGGCCGTGGGCTCCGTCAAGATGCAGCCGCCGTGCGAGAGCCCGGCCCTGGCCGCCGCGGCGGCGGTGGTGGCGGCAGACGGCCCCCTG CGCCGCAGCCCCAGCGCCCGGGAGCCCGAGCGCGAGCAGCCGCCGGCGTCGCTGCGGCCGCGGCTGAGGGACCTGCCCGCGCTGCTGCGG AGCGGGCTCACGCTGCGGAGGAAGCGGAGCGCCGCTGGGGGCCGGACTCTATCAAGAAGAATATCTAATCCGTACCTTGAACATACGCCT TCCCAGATTTATGGAGAGAATTCTTCTTGTGCAGGAAGAGCATTGAGGAATATTATTATCGTTCAAGCAGCTGACCTGATAAAGGACAGA GTGAACCTCAAGGGGTTTTACAGGAGGAGCTGCGTTGGGTCAGAGCTGGTAGACTGGCTTCTAGAACACTGTCCTTTCGTCCAGTGCAGA TCTATGGCCATAGGAGTCTGGCAACTCCTACTGGACATGGGAATTATGTTATCAGTGGACCAGCATCTATACTTTCAAGATACTTATGTT TTCTACCAGTTTTCCTCTGATGAATGTAGCTACTTGTACTGTGAATTTGAAAGAGAAGAAGAATGGCAAAATGGTGTCAAGCTTTTACTG CAACTTGTGCCTCTCATTCCTGCCAGAGGTGGCATCTGTGAACTGTCCTATGGCAGCGTATACAAAGCTATTCATAAAGAGACCGGCCAG ATTGTTGCTATTAAGCAAGTTCCTGTGGAATCAGACCTCCAGGAGATAATCAAAGAAATCTCTATAATGCAGCAATGTGACAGCCCTCAT GTAGTCAAATATTATGGCAGTTATTTTAAGAACACAGACTTATGGATCGTTATGGAGTACTGTGGGGCTGGTTCTGTATCTGATATCATT CGATTACGAAATAAAACGTTAACAGAAGATGAAATAGCTACAATATTACAATCAACTCTTAAGGGACTTGAATACCTTCATTTTATGAGA AAAATACACCGAGATATCAAGGCAGGAAATATTTTGCTAAATACAGAAGGACATGCAAAACTTGCAGATTTTGGGGTAGCAGGTCAACTT ACAGATACCATGGCCAAGCGGAATACAGTGATAGGAACACCATTTTGGATGGCTCCAGAAGTGATTCAGGAAATTGGATACAACTGTGTA GCAGACATCTGGTCCCTGGGAATAACTGCCATAGAAATGGCTGAAGGAAAGCCCCCTTATGCTGATATCCATCCAATGAGGGCAATCTTC ATGATTCCTACAAATCCTCCTCCCACATTCCGAAAACCAGAGCTATGGTCAGATAACTTTACAGATTTTGTGAAACAGTGTCTTGTAAAG AGCCCTGAGCAGAGGGCCACAGCCACTCAGCTCCTGCAGCACCCATTTGTCAGGAGTGCCAAAGGAGTGTCAATACTGCGAGACTTAATT AATGAAGCCATGGATGTGAAACTGAAACGCCAGGAATCCCAGCAGCGGGAAGTGGACCAGGACGATGAAGAAAACTCAGAAGAGGATGAA ATGGATTCTGGCACGATGGTTCGAGCAGTGGGTGATGAGATGGGCACTGTCCGAGTAGCCAGCACCATGACTGATGGAGCCAATACTATG ATTGAGCACGATGACACGTTGCCATCACAACTGGGCACCATGGTGATCAATGCAGAGGATGAGGAAGAGGAAGGAACTATGAAAAGAAGG GATGAGACCATGCAGCCTGCGAAACCATCCTTTCTTGAATATTTTGAACAAAAAGAAAAGGAAAACCAGATCAACAGCTTTGGCAAGAGT GTACCTGGTCCACTGAAAAATTCTTCAGATTGGAAAATACCACAGGATGGAGACTACGAGTTTAAAACTAGCCAAGAACAGCAGTCTGGA AAAGACATATGTATCCAAAATTGCCAGGGAAACCTGCTGTGTAGATACGCTTTCTGAGAAACCACATGCTTAAGAGTTGGACAGTGGAGG ACCTTCAGAAGAGGCTCTTGGCCCTGGACCCCATGATGGAGCAGGAGATTGAAGAGATCCGGCAGAAGTACCAGTCCAAGCGGCAGCCCA TCCTGGATGCCATAGAGGCTAAGAAGAGACGGCAACAAAACTTCTGAGCAAGGCCAGGCTGTGAGGGCCCCAGCTCCACCCAGGCTTTGG GTGAATTCTGGATGGCTTGCCTCATGTTTGTTAGCCAGCACTTCTGCTCTGTCGTCTCTCCACAGCACCTTTGTGAACTCAGGAATGTGC GCCAGTGGGAAGGGCTCTCTTGACAGTCAGCGTGCCATCTTGATGTGTGTATGTACATTGGTCAGGTATATTATCTCAAAGGATTTATAT TGGCGCTTTTAACTCAGAGTTTTAAACCCCAGGAACAGAGACTCCTAGTTGAGTGATAGCTGGGAAAGTTTTACATTGTCTGTTTTTCTT CTCCCAATAGCTTTCAATTGTTCTTTCTGGAAGACTTTTAAAAAAATATAAATATGCATATATATATATAAATTATAAATAGATTCCCCA >72253_72253_5_RAPGEF5-STK4_RAPGEF5_chr7_22347958_ENST00000405243_STK4_chr20_43607084_ENST00000372801_length(amino acids)=675AA_BP=252 MAKARTARGGERGGEEPPAPQRRQGMRMAVGSVKMQPPCESPALAAAAAVVAADGPLRRSPSAREPEREQPPASLRPRLRDLPALLRSGL TLRRKRSAAGGRTLSRRISNPYLEHTPSQIYGENSSCAGRALRNIIIVQAADLIKDRVNLKGFYRRSCVGSELVDWLLEHCPFVQCRSMA IGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDECSYLYCEFEREEEWQNGVKLLLQLVPLIPARGGICELSYGSVYKAIHKETGQIVA IKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIH RDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIP TNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDS GTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPG -------------------------------------------------------------- >72253_72253_6_RAPGEF5-STK4_RAPGEF5_chr7_22347958_ENST00000405243_STK4_chr20_43607084_ENST00000372806_length(transcript)=6895nt_BP=764nt TCTCGCTTCCTGGCGAAGGCGCGGACGGCGCGCGGAGGCGAGCGCGGTGGAGAGGAGCCCCCGGCGCCGCAGCGCCGTCAGGGCATGAGG ATGGCCGTGGGCTCCGTCAAGATGCAGCCGCCGTGCGAGAGCCCGGCCCTGGCCGCCGCGGCGGCGGTGGTGGCGGCAGACGGCCCCCTG CGCCGCAGCCCCAGCGCCCGGGAGCCCGAGCGCGAGCAGCCGCCGGCGTCGCTGCGGCCGCGGCTGAGGGACCTGCCCGCGCTGCTGCGG AGCGGGCTCACGCTGCGGAGGAAGCGGAGCGCCGCTGGGGGCCGGACTCTATCAAGAAGAATATCTAATCCGTACCTTGAACATACGCCT TCCCAGATTTATGGAGAGAATTCTTCTTGTGCAGGAAGAGCATTGAGGAATATTATTATCGTTCAAGCAGCTGACCTGATAAAGGACAGA GTGAACCTCAAGGGGTTTTACAGGAGGAGCTGCGTTGGGTCAGAGCTGGTAGACTGGCTTCTAGAACACTGTCCTTTCGTCCAGTGCAGA TCTATGGCCATAGGAGTCTGGCAACTCCTACTGGACATGGGAATTATGTTATCAGTGGACCAGCATCTATACTTTCAAGATACTTATGTT TTCTACCAGTTTTCCTCTGATGAATGTAGCTACTTGTACTGTGAATTTGAAAGAGAAGAAGAATGGCAAAATGGTGTCAAGCTTTTACTG CAACTTGTGCCTCTCATTCCTGCCAGAGGTGGCATCTGTGAACTGTCCTATGGCAGCGTATACAAAGCTATTCATAAAGAGACCGGCCAG ATTGTTGCTATTAAGCAAGTTCCTGTGGAATCAGACCTCCAGGAGATAATCAAAGAAATCTCTATAATGCAGCAATGTGACAGCCCTCAT GTAGTCAAATATTATGGCAGTTATTTTAAGAACACAGACTTATGGATCGTTATGGAGTACTGTGGGGCTGGTTCTGTATCTGATATCATT CGATTACGAAATAAAACGTTAACAGAAGATGAAATAGCTACAATATTACAATCAACTCTTAAGGGACTTGAATACCTTCATTTTATGAGA AAAATACACCGAGATATCAAGGCAGGAAATATTTTGCTAAATACAGAAGGACATGCAAAACTTGCAGATTTTGGGGTAGCAGGTCAACTT ACAGATACCATGGCCAAGCGGAATACAGTGATAGGAACACCATTTTGGATGGCTCCAGAAGTGATTCAGGAAATTGGATACAACTGTGTA GCAGACATCTGGTCCCTGGGAATAACTGCCATAGAAATGGCTGAAGGAAAGCCCCCTTATGCTGATATCCATCCAATGAGGGCAATCTTC ATGATTCCTACAAATCCTCCTCCCACATTCCGAAAACCAGAGCTATGGTCAGATAACTTTACAGATTTTGTGAAACAGTGTCTTGTAAAG AGCCCTGAGCAGAGGGCCACAGCCACTCAGCTCCTGCAGCACCCATTTGTCAGGAGTGCCAAAGGAGTGTCAATACTGCGAGACTTAATT AATGAAGCCATGGATGTGAAACTGAAACGCCAGGAATCCCAGCAGCGGGAAGTGGACCAGGACGATGAAGAAAACTCAGAAGAGGATGAA ATGGATTCTGGCACGATGGTTCGAGCAGTGGGTGATGAGATGGGCACTGTCCGAGTAGCCAGCACCATGACTGATGGAGCCAATACTATG ATTGAGCACGATGACACGTTGCCATCACAACTGGGCACCATGGTGATCAATGCAGAGGATGAGGAAGAGGAAGGAACTATGAAAAGAAGG GATGAGACCATGCAGCCTGCGAAACCATCCTTTCTTGAATATTTTGAACAAAAAGAAAAGGAAAACCAGATCAACAGCTTTGGCAAGAGT GTACCTGGTCCACTGAAAAATTCTTCAGATTGGAAAATACCACAGGATGGAGACTACGAGTTTCTTAAGAGTTGGACAGTGGAGGACCTT CAGAAGAGGCTCTTGGCCCTGGACCCCATGATGGAGCAGGAGATTGAAGAGATCCGGCAGAAGTACCAGTCCAAGCGGCAGCCCATCCTG GATGCCATAGAGGCTAAGAAGAGACGGCAACAAAACTTCTGAGCAAGGCCAGGCTGTGAGGGCCCCAGCTCCACCCAGGCTTTGGGTGAA TTCTGGATGGCTTGCCTCATGTTTGTTAGCCAGCACTTCTGCTCTGTCGTCTCTCCACAGCACCTTTGTGAACTCAGGAATGTGCGCCAG TGGGAAGGGCTCTCTTGACAGTCAGCGTGCCATCTTGATGTGTGTATGTACATTGGTCAGGTATATTATCTCAAAGGATTTATATTGGCG CTTTTAACTCAGAGTTTTAAACCCCAGGAACAGAGACTCCTAGTTGAGTGATAGCTGGGAAAGTTTTACATTGTCTGTTTTTCTTCTCCC AATAGCTTTCAATTGTTCTTTCTGGAAGACTTTTAAAAAAATATAAATATGCATATATATATATAAATTATAAATAGATTCCCCACGCAG TGTGGTGGCATCTCTGTACAGGTACAGTTTTAAACGGTTTGCCTCTTTTCTGTAAGATTATGGTACTGTGGAACATGAGGGCAGAGGACA CCGGGAGGCTGTTAGGGGGTCACTGAATCCCAGGAGCCAACCTCCCCCTTTGCAGGGCTGCATTTAAAAATTAGGTTTGGGACAGTTCTT GTACCGTGGTTTCAGCCTTGTGTGGTCATCACTGGCTTCTGGAGCTATTGGTGATGTCCAAGGGAAAGCTTTGAGAGTTTATGTTTACTC TTTGAGTCCCAGGAGAAGCCTGGCACCCTCTTTGCAAATTGGCCTTTGCTCTTTCAATGCCTTTCATCCATCTCCACTCTCTCAACTGCC TAAAGTCACAGCACAGATACTGCCCAGTGCCTTAAGAGGAGACATGATCTCTACCAGGGACTCTCAGCAAACACGGGACTGTGTTCAGTC CACAAAGGAAAAGCGTTTTTGAAGCTCTCATTGTTCATGTAAAAATCATACACGTGGCATGTTGCTCCACATTCCTTACACACAGGGGTA GAGGGGATTGCTTTTGTGACCCACGTTCAAATATGTGACTGTTTTCTTTTCTCTTTTACTGCTAAGCAGCCTGGAAAGGATAAATGAATA TTAGACTAAGATTTGTTTTCCAGGAGGCTCAATCTGAACACACAGAATGTCAGAGCTGGAAGGGACTATAGAGATCATCTGATCTGATCC TCTTGTACGGATGATCGCAAAACTGAGGTGTAGAGAGGGGAATGGCCAAAATCACAAAGCAAGTTAGCGTTAAGAGCTGAGACTAGAATT CAGGGTCCTCACTCCCAGGCCACCGAACCATGCAGCCCCTTCTTTGGGGGAAGAGACCTGTGTCAGTCTTGGTTAATTGTTCCAGGGAAC CTTGCTAACAGAAACTTGCTCTTGCCTTGGCTCTTCAGTAGATGACCTGGCTGTAAAGAGATTCCCTGGACGAGCCAGATCATTCAGTTT CAGCGAGTCCTTGAGCTCCACAACATCTACCAGATATAGCAGACAAGCACCCATGGAGGCAGGTTTCGGGCCTGAAGCAGATCAGAGGGC TTTGCAAAAGACAGCATAGAGCCATCTTCCTGCAACTTTACCTCTTTCCCTCAGATGGGGAGCCATGACTGGGTTGCACCTCAGGATACT GTAATTTGACTCCATAATTGCTTTTGCTCCTGAAACCTGGGAATCAATGGAAAGGCAGGGAATGTGCCTCTTCTGTGGCCAGATTCTGTT ATTTGCAATTAAAGCAAGTTTTTAAAAAATGCAAGAGGCAGTTGTTAGTCTTCAGGGCTTGGCAACTGAAATAGCTATGTGGCGGATACG GAAAACAGAGGACAATTTGAGGATCTTGCTGGAATAATAAATGACAGCTACCATTTGTTGAGCACCTATTATATATCAGGCACTGAGCTG GGTAGGCTCTAAACTTCACAATAACCCTGTGACTTAACTACTTTATCTCCATTTTGTAGTTGAAGAAATAAGTTCAGAGAGAAAGATTCC TTCCCAAGGTCATGCAGCTAGTAAATGATAGAATCAGGATTCATAGCATCACTATAGGGGGTCAATATTTACACAAAAAAGGAAAGTCAC AAGCCTGTTTAAAATGAAGTGACCACCTTTTCTTGCATAGACTAAATAACTCGAACTGGCATTTTTAGGTTGGAAAGACAGCTGAATTAG TAGTTAAGTCTGATAGCCAAGTAAGTTTTAAAAACCAAAGCATCCAGGATGCACACCCCTGCACCATTTGCTGTGCGAATTAATAGTTCT GTCTCTCTCTCTCTTTCTTTTTTCTTTTTATTCTTTGAGATGGATTTTCGCTCTTGTCGCCCAGGCTGGAGTACAATGGCACGATCTTGG CTCACTGCAACCTCCGCCTCCCGGGTTCAAGCGATTCTTCTGCTGGGATTACAGCATATGCCACCATGCCCAGATTATTTTTTTGTATTT GTAGTAGAGACGGGGTTTCACCATGTCAGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCCACACTGCT GGGATTACAGGCATGAGCCACCGCTCCTGGCCTCTCTTTCTTTTTTAAACAAAGAACTTTGCACTTGGCCAGAGAGGAGGAGAAAGCCCA TTTTCTCCCTTCCTAAGCTAGATCCAAATAAAAGAAAGTTCAGTTTTCCCCCATAACTATTCTTGGGTCATGAACTTTGATCTGGAGTTT GTTTTGTTTCAGGAATGTGTGCACCCAGCTTGCTGATCCAACAAAGTCTATTGCTTACCAGTCTAGCTTGATGAAGCCTTTTGGCCAGAA GTCAATTTGTTTTGGATCAGAGAAATTTCCTGACAAGGTATATTTGTTTTCTAGTGACAGAAAGGCAAAGGAACAAGTCCTAGTTGTTGT TGTTGTTGTTGAATACTAAATTTAAGATATGTCAGCTTGCTTTCAATGAGCCTTGGGCTTCTGTTATTGCTTGAGCATTTGGAACTCGAG CTTCCAGAGAAATTTGAGGTCCTCGCTTGTTCTCTGCCTTCAAGAAACAATGACCTGATTCTGTCTTTAAAAAAAAAAATCTCAGAATTC TTTTTTTGTTTGTGTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCCATCTCGGCTCACTGC AACCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAGGTAGCTGCCACTACAGGTGCTGCACCACCACGCCCGGCTAAT TTTTGTATTTTTAGTAGAGACAGGGTTTCACCATATTAGCCAGGTGGGTCTTGAACTCCTGACCTTGTGATCCACCCGCCTCGGCCTCCC AAAGTGCTGGGATTACAGGCGTGAGCCACCTTGCCTGGCCAAAAATCTCAGAATTCTTTAAGACTGTTTTAATTGCTCCATCAGTAATTT TGAAGCACTTTCCTTTTTTTTTTTTTTTCCCCTTTTTGTCCCTTTCCCCAAGCCACCAATTGGATGGATGAATGTTTGACGGGGAAGAGG AAGGGTAGGAGGATGCATGGATGAGTGGATGAGTGGATCGATGGATGTATTGATAAATAGATAGAACCAGTCATCTGAAGCAACTTAAGA ATTGTAGCCTTGACTCCTTGAGACTGTAGATTTCGATCCAGGAAACATTTATTTAGCACCTGCCAGATGCCAGAAATTTATACCATTTAA AACTCAGTAAGTCTTTTAAATATCAGGAAGGAGAGAAGCGACATCATGATACATCCTATGGGTATTAAAAAGCCAATAGAATATTATGAA TAATTTTATGCTAATAAATTTAACAACTTCAACATCATAAACAAATTCCTTGAAAAATAAAAAGTACCAAAATTCATTCAAGAAGAAATA GATACCAGCCTGAGCAACATGGCAAAATCCCATCTCTACAAAACATCAAAAAAAAAAAAAATTAGTCGGGCATGGTGGTGCACACCTGTA ATCCCAGCTTGTCAGGAGGCTGAAGTGGGAGGATCACCTGAGCCCAGGGAGGTCAAGGATGCAGTGAGCCATGGTCTCACCACTGCACTC TAGCCTGGGTGACAGAATGAGACCCCGTCTCAAAAAAAAAGAAGAAGTAGATAATCTGAATAGCCCTATATCTATAGAAACTTAATAGTG CTGGGAGATATAGGTATTATTATCCTCATTTTACAGATGTGAAAATTGAGGCTCAGAGAAGTAAAGTCTATTGCTCAAGGTCATGTGGCT AGAATATGGCAGAGCCATGATTCAGATCCAGGTCTTCTGATTCTTATTCCAGTGTCCTTTCTAGCATACCATGTTGCCTCTAAAGATTGC AGCTCCTTATTTACTAGAAAATTGTTCCTGCCCAATCTACATCTCCACCTCACCCCATCTTTTCTTAAGCACTATGTTTGTGTTTTTATC AGTATTATATTCATTGTCTTTGGAATACATGTTCTTGTTTGTGTTTGGAAAAAAAATCTCTTTTACCAGCTTGCACTCGGACCAACTTGG AAAAAAAAAAGCTTAAATGTTTTTGCTATGTACAGTTTAAAAATGTGAAGTTTGTAGCTTTAACTTTTTGTAAGAAAATCTAATAACACT GGCTTAAGTGCTGACTTGAAATGCTATTTTGTAAGGTTTGGATGTAAGTAATCAATTGAGGTCAGCAGTTTGTATGAGACATAGCTTCCT CCATTGCCCCCACTCCTTTTTTCTTTTTTAAGTTTGAGATGCTTCCTGTGTTTTTATGTTAGAATTGTTGTTCTCCTTCTTTTCTTCTTC >72253_72253_6_RAPGEF5-STK4_RAPGEF5_chr7_22347958_ENST00000405243_STK4_chr20_43607084_ENST00000372806_length(amino acids)=700AA_BP=252 MAKARTARGGERGGEEPPAPQRRQGMRMAVGSVKMQPPCESPALAAAAAVVAADGPLRRSPSAREPEREQPPASLRPRLRDLPALLRSGL TLRRKRSAAGGRTLSRRISNPYLEHTPSQIYGENSSCAGRALRNIIIVQAADLIKDRVNLKGFYRRSCVGSELVDWLLEHCPFVQCRSMA IGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDECSYLYCEFEREEEWQNGVKLLLQLVPLIPARGGICELSYGSVYKAIHKETGQIVA IKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIH RDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIP TNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDS GTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPG -------------------------------------------------------------- >72253_72253_7_RAPGEF5-STK4_RAPGEF5_chr7_22347958_ENST00000405243_STK4_chr20_43607084_ENST00000396731_length(transcript)=2037nt_BP=764nt TCTCGCTTCCTGGCGAAGGCGCGGACGGCGCGCGGAGGCGAGCGCGGTGGAGAGGAGCCCCCGGCGCCGCAGCGCCGTCAGGGCATGAGG ATGGCCGTGGGCTCCGTCAAGATGCAGCCGCCGTGCGAGAGCCCGGCCCTGGCCGCCGCGGCGGCGGTGGTGGCGGCAGACGGCCCCCTG CGCCGCAGCCCCAGCGCCCGGGAGCCCGAGCGCGAGCAGCCGCCGGCGTCGCTGCGGCCGCGGCTGAGGGACCTGCCCGCGCTGCTGCGG AGCGGGCTCACGCTGCGGAGGAAGCGGAGCGCCGCTGGGGGCCGGACTCTATCAAGAAGAATATCTAATCCGTACCTTGAACATACGCCT TCCCAGATTTATGGAGAGAATTCTTCTTGTGCAGGAAGAGCATTGAGGAATATTATTATCGTTCAAGCAGCTGACCTGATAAAGGACAGA GTGAACCTCAAGGGGTTTTACAGGAGGAGCTGCGTTGGGTCAGAGCTGGTAGACTGGCTTCTAGAACACTGTCCTTTCGTCCAGTGCAGA TCTATGGCCATAGGAGTCTGGCAACTCCTACTGGACATGGGAATTATGTTATCAGTGGACCAGCATCTATACTTTCAAGATACTTATGTT TTCTACCAGTTTTCCTCTGATGAATGTAGCTACTTGTACTGTGAATTTGAAAGAGAAGAAGAATGGCAAAATGGTGTCAAGCTTTTACTG CAACTTGTGCCTCTCATTCCTGCCAGAGGTGGCATCTGTGAACTGTCCTATGGCAGCGTATACAAAGCTATTCATAAAGAGACCGGCCAG ATTGTTGCTATTAAGCAAGTTCCTGTGGAATCAGACCTCCAGGAGATAATCAAAGAAATCTCTATAATGCAGCAATGTGACAGCCCTCAT GTAGTCAAATATTATGGCAGTTATTTTAAGAACACAGACTTATGGATCGTTATGGAGTACTGTGGGGCTGGTTCTGTATCTGATATCATT CGATTACGAAATAAAACGTTAACAGAAGATGAAATAGCTACAATATTACAATCAACTCTTAAGGGACTTGAATACCTTCATTTTATGAGA AAAATACACCGAGATATCAAGGCAGGAAATATTTTGCTAAATACAGAAGGACATGCAAAACTTGCAGATTTTGGGGTAGCAGGTCAACTT ACAGATACCATGGCCAAGCGGAATACAGTGATAGGAACACCATTTTGGATGGCTCCAGAAGTGATTCAGGAAATTGGATACAACTGTGTA GCAGACATCTGGTCCCTGGGAATAACTGCCATAGAAATGGCTGAAGGAAAGCCCCCTTATGCTGATATCCATCCAATGAGGGCAATCTTC ATGATTCCTACAAATCCTCCTCCCACATTCCGAAAACCAGAGCTATGGTCAGATAACTTTACAGATTTTGTGAAACAGTGTCTTGTAAAG AGCCCTGAGCAGAGGGCCACAGCCACTCAGCTCCTGCAGCACCCATTTGTCAGGAGTGCCAAAGGAGTGTCAATACTGCGAGACTTAATT AATGAAGCCATGGATGTGAAACTGAAACGCCAGGAATCCCAGCAGCGGGAAGTGGACCAGGACGATGAAGAAAACTCAGAAGAGGATGAA ATGGATTCTGGCACGATGGTTCGAGCAGTGGGTGATGAGATGGGCACTGTCCGAGTAGCCAGCACCATGACTGATGGAGCCAATACTATG ATTGAGCACGATGACACGTTGCCATCACAACTGGGCACCATGGTGATCAATGCAGAGGATGAGGAAGAGGAAGGAACTATGAAAAGAAGG GATGAGACCATGCAGCCTGCGAAACCATCCTTTCTTGAATATTTTGAACAAAAAGAAAAGGAAAACCAGATCAACAGCTTTGGCAAGAGT GTACCTGGTCCACTGAAAAATTCTTCAGATTGGAAAATACCACAGGATGGAGACTACGAGTTTAAAACTAGCCAAGAACAGCAGTCTGGA >72253_72253_7_RAPGEF5-STK4_RAPGEF5_chr7_22347958_ENST00000405243_STK4_chr20_43607084_ENST00000396731_length(amino acids)=675AA_BP=252 MAKARTARGGERGGEEPPAPQRRQGMRMAVGSVKMQPPCESPALAAAAAVVAADGPLRRSPSAREPEREQPPASLRPRLRDLPALLRSGL TLRRKRSAAGGRTLSRRISNPYLEHTPSQIYGENSSCAGRALRNIIIVQAADLIKDRVNLKGFYRRSCVGSELVDWLLEHCPFVQCRSMA IGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDECSYLYCEFEREEEWQNGVKLLLQLVPLIPARGGICELSYGSVYKAIHKETGQIVA IKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIH RDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIP TNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDS GTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPG -------------------------------------------------------------- >72253_72253_8_RAPGEF5-STK4_RAPGEF5_chr7_22347958_ENST00000405243_STK4_chr20_43607084_ENST00000499879_length(transcript)=5822nt_BP=764nt TCTCGCTTCCTGGCGAAGGCGCGGACGGCGCGCGGAGGCGAGCGCGGTGGAGAGGAGCCCCCGGCGCCGCAGCGCCGTCAGGGCATGAGG ATGGCCGTGGGCTCCGTCAAGATGCAGCCGCCGTGCGAGAGCCCGGCCCTGGCCGCCGCGGCGGCGGTGGTGGCGGCAGACGGCCCCCTG CGCCGCAGCCCCAGCGCCCGGGAGCCCGAGCGCGAGCAGCCGCCGGCGTCGCTGCGGCCGCGGCTGAGGGACCTGCCCGCGCTGCTGCGG AGCGGGCTCACGCTGCGGAGGAAGCGGAGCGCCGCTGGGGGCCGGACTCTATCAAGAAGAATATCTAATCCGTACCTTGAACATACGCCT TCCCAGATTTATGGAGAGAATTCTTCTTGTGCAGGAAGAGCATTGAGGAATATTATTATCGTTCAAGCAGCTGACCTGATAAAGGACAGA GTGAACCTCAAGGGGTTTTACAGGAGGAGCTGCGTTGGGTCAGAGCTGGTAGACTGGCTTCTAGAACACTGTCCTTTCGTCCAGTGCAGA TCTATGGCCATAGGAGTCTGGCAACTCCTACTGGACATGGGAATTATGTTATCAGTGGACCAGCATCTATACTTTCAAGATACTTATGTT TTCTACCAGTTTTCCTCTGATGAATGTAGCTACTTGTACTGTGAATTTGAAAGAGAAGAAGAATGGCAAAATGGTGTCAAGCTTTTACTG CAACTTGTGCCTCTCATTCCTGCCAGAGGTGGCATCTGTGAACTGTCCTATGGCAGCGTATACAAAGCTATTCATAAAGAGACCGGCCAG ATTGTTGCTATTAAGCAAGTTCCTGTGGAATCAGACCTCCAGGAGATAATCAAAGAAATCTCTATAATGCAGCAATGTGACAGCCCTCAT GTAGTCAAATATTATGGCAGTTATTTTAAGAACACAGACTTATGGATCGTTATGGAGTACTGTGGGGCTGGTTCTGTATCTGATATCATT CGATTACGAAATAAAACGGATACCATGGCCAAGCGGAATACAGTGATAGGAACACCATTTTGGATGGCTCCAGAAGTGATTCAGGAAATT GGATACAACTGTGTAGCAGACATCTGGTCCCTGGGAATAACTGCCATAGAAATGGCTGAAGGAAAGCCCCCTTATGCTGATATCCATCCA ATGAGGGCAATCTTCATGATTCCTACAAATCCTCCTCCCACATTCCGAAAACCAGAGCTATGGTCAGATAACTTTACAGATTTTGTGAAA CAGTGTCTTGTAAAGAGCCCTGAGCAGAGGGCCACAGCCACTCAGCTCCTGCAGCACCCATTTGTCAGGAGTGCCAAAGGAGTGTCAATA CTGCGAGACTTAATTAATGAAGCCATGGATGTGAAACTGAAACGCCAGGAATCCCAGCAGCGGGAAGTGGACCAGGACGATGAAGAAAAC TCAGAAGAGGATGAAATGGATTCTGGCACGATGGTTCGAGCAGTGGGTGATGAGATGGGCACTGTCCGAGTAGCCAGCACCATGACTGAT GGAGCCAATACTATGATTGAGCACGATGACACGTTGCCATCACAACTGGGCACCATGGTGATCAATGCAGAGGATGAGGAAGAGGAAGGA ACTATGAAAAGAAGGGATGAGACCATGCAGCCTGCGAAACCATCCTTTCTTGAATATTTTGAACAAAAAGAAAAGGAAAACCAGATCAAC AGCTTTGGCAAGAGTGTACCTGGTCCACTGAAAAATTCTTCAGATTGGAAAATACCACAGGATGGAGACTACGAGTTTCTTAAGAGTTGG ACAGTGGAGGACCTTCAGAAGAGGCTCTTGGCCCTGGACCCCATGATGGAGCAGGAGATTGAAGAGATCCGGCAGAAGTACCAGTCCAAG CGGCAGCCCATCCTGGATGCCATAGAGGCTAAGAAGAGACGGCAACAAAACTTCTGAGCAAGGCCAGGCTGTGAGGGCCCCAGCTCCACC CAGGCTTTGGGTGAATTCTGGATGGCTTGCCTCATGTTTGTTAGCCAGCACTTCTGCTCTGTCGTCTCTCCACAGCACCTTTGTGAACTC AGGAATGTGCGCCAGTGGGAAGGGCTCTCTTGACAGTCAGCGTGCCATCTTGATGTGTGTATGTACATTGGTCAGGTATATTATCTCAAA GGATTTATATTGGCGCTTTTAACTCAGAGTTTTAAACCCCAGGAACAGAGACTCCTAGTTGAGTGATAGCTGGGAAAGTTTTACATTGTC TGTTTTTCTTCTCCCAATAGCTTTCAATTGTTCTTTCTGGAAGACTTTTAAAAAAATATAAATATGCATATATATATATAAATTATAAAT AGATTCCCCACGCAGTGTGGTGGCATCTCTGTACAGGTACAGTTTTAAACGGTTTGCCTCTTTTCTGTAAGATTATGGTACTGTGGAACA TGAGGGCAGAGGACACCGGGAGGCTGTTAGGGGGTCACTGAATCCCAGGAGCCAACCTCCCCCTTTGCAGGGCTGCATTTAAAAATTAGG TTTGGGACAGTTCTTGTACCGTGGTTTCAGCCTTGTGTGGTCATCACTGGCTTCTGGAGCTATTGGTGATGTCCAAGGGAAAGCTTTGAG AGTTTATGTTTACTCTTTGAGTCCCAGGAGAAGCCTGGCACCCTCTTTGCAAATTGGCCTTTGCTCTTTCAATGCCTTTCATCCATCTCC ACTCTCTCAACTGCCTAAAGTCACAGCACAGATACTGCCCAGTGCCTTAAGAGGAGACATGATCTCTACCAGGGACTCTCAGCAAACACG GGACTGTGTTCAGTCCACAAAGGAAAAGCGTTTTTGAAGCTCTCATTGTTCATGTAAAAATCATACACGTGGCATGTTGCTCCACATTCC TTACACACAGGGGTAGAGGGGATTGCTTTTGTGACCCACGTTCAAATATGTGACTGTTTTCTTTTCTCTTTTACTGCTAAGCAGCCTGGA AAGGATAAATGAATATTAGACTAAGATTTGTTTTCCAGGAGGCTCAATCTGAACACACAGAATGTCAGAGCTGGAAGGGACTATAGAGAT CATCTGATCTGATCCTCTTGTACGGATGATCGCAAAACTGAGGTGTAGAGAGGGGAATGGCCAAAATCACAAAGCAAGTTAGCGTTAAGA GCTGAGACTAGAATTCAGGGTCCTCACTCCCAGGCCACCGAACCATGCAGCCCCTTCTTTGGGGGAAGAGACCTGTGTCAGTCTTGGTTA ATTGTTCCAGGGAACCTTGCTAACAGAAACTTGCTCTTGCCTTGGCTCTTCAGTAGATGACCTGGCTGTAAAGAGATTCCCTGGACGAGC CAGATCATTCAGTTTCAGCGAGTCCTTGAGCTCCACAACATCTACCAGATATAGCAGACAAGCACCCATGGAGGCAGGTTTCGGGCCTGA AGCAGATCAGAGGGCTTTGCAAAAGACAGCATAGAGCCATCTTCCTGCAACTTTACCTCTTTCCCTCAGATGGGGAGCCATGACTGGGTT GCACCTCAGGATACTGTAATTTGACTCCATAATTGCTTTTGCTCCTGAAACCTGGGAATCAATGGAAAGGCAGGGAATGTGCCTCTTCTG TGGCCAGATTCTGTTATTTGCAATTAAAGCAAGTTTTTAAAAAATGCAAGAGGCAGTTGTTAGTCTTCAGGGCTTGGCAACTGAAATAGC TATGTGGCGGATACGGAAAACAGAGGACAATTTGAGGATCTTGCTGGAATAATAAATGACAGCTACCATTTGTTGAGCACCTATTATATA TCAGGCACTGAGCTGGGTAGGCTCTAAACTTCACAATAACCCTGTGACTTAACTACTTTATCTCCATTTTGTAGTTGAAGAAATAAGTTC AGAGAGAAAGATTCCTTCCCAAGGTCATGCAGCTAGTAAATGATAGAATCAGGATTCATAGCATCACTATAGGGGGTCAATATTTACACA AAAAAGGAAAGTCACAAGCCTGTTTAAAATGAAGTGACCACCTTTTCTTGCATAGACTAAATAACTCGAACTGGCATTTTTAGGTTGGAA AGACAGCTGAATTAGTAGTTAAGTCTGATAGCCAAGTAAGTTTTAAAAACCAAAGCATCCAGGATGCACACCCCTGCACCATTTGCTGTG CGAATTAATAGTTCTGTCTCTCTCTCTCTTTCTTTTTTCTTTTTATTCTTTGAGATGGATTTTCGCTCTTGTCGCCCAGGCTGGAGTACA ATGGCACGATCTTGGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGCGATTCTTCTGCTGGGATTACAGCATATGCCACCATGCCCAGAT TATTTTTTTGTATTTGTAGTAGAGACGGGGTTTCACCATGTCAGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCGCCTCA GCCTCCCACACTGCTGGGATTACAGGCATGAGCCACCGCTCCTGGCCTCTCTTTCTTTTTTAAACAAAGAACTTTGCACTTGGCCAGAGA GGAGGAGAAAGCCCATTTTCTCCCTTCCTAAGCTAGATCCAAATAAAAGAAAGTTCAGTTTTCCCCCATAACTATTCTTGGGTCATGAAC TTTGATCTGGAGTTTGTTTTGTTTCAGGAATGTGTGCACCCAGCTTGCTGATCCAACAAAGTCTATTGCTTACCAGTCTAGCTTGATGAA GCCTTTTGGCCAGAAGTCAATTTGTTTTGGATCAGAGAAATTTCCTGACAAGGTATATTTGTTTTCTAGTGACAGAAAGGCAAAGGAACA AGTCCTAGTTGTTGTTGTTGTTGTTGAATACTAAATTTAAGATATGTCAGCTTGCTTTCAATGAGCCTTGGGCTTCTGTTATTGCTTGAG CATTTGGAACTCGAGCTTCCAGAGAAATTTGAGGTCCTCGCTTGTTCTCTGCCTTCAAGAAACAATGACCTGATTCTGTCTTTAAAAAAA AAAATCTCAGAATTCTTTTTTTGTTTGTGTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCC ATCTCGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAGGTAGCTGCCACTACAGGTGCTGCACCA CCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATATTAGCCAGGTGGGTCTTGAACTCCTGACCTTGTGATCCAC CCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCTTGCCTGGCCAAAAATCTCAGAATTCTTTAAGACTGTTTTAATTG CTCCATCAGTAATTTTGAAGCACTTTCCTTTTTTTTTTTTTTTCCCCTTTTTGTCCCTTTCCCCAAGCCACCAATTGGATGGATGAATGT TTGACGGGGAAGAGGAAGGGTAGGAGGATGCATGGATGAGTGGATGAGTGGATCGATGGATGTATTGATAAATAGATAGAACCAGTCATC TGAAGCAACTTAAGAATTGTAGCCTTGACTCCTTGAGACTGTAGATTTCGATCCAGGAAACATTTATTTAGCACCTGCCAGATGCCAGAA ATTTATACCATTTAAAACTCAGTAAGTCTTTTAAATATCAGGAAGGAGAGAAGCGACATCATGATACATCCTATGGGTATTAAAAAGCCA ATAGAATATTATGAATAATTTTATGCTAATAAATTTAACAACTTCAACATCATAAACAAATTCCTTGAAAAATAAAAAGTACCAAAATTC >72253_72253_8_RAPGEF5-STK4_RAPGEF5_chr7_22347958_ENST00000405243_STK4_chr20_43607084_ENST00000499879_length(amino acids)=645AA_BP=252 MAKARTARGGERGGEEPPAPQRRQGMRMAVGSVKMQPPCESPALAAAAAVVAADGPLRRSPSAREPEREQPPASLRPRLRDLPALLRSGL TLRRKRSAAGGRTLSRRISNPYLEHTPSQIYGENSSCAGRALRNIIIVQAADLIKDRVNLKGFYRRSCVGSELVDWLLEHCPFVQCRSMA IGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDECSYLYCEFEREEEWQNGVKLLLQLVPLIPARGGICELSYGSVYKAIHKETGQIVA IKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTDTMAKRNTVIGTPFWMAPEVIQEIGYN CVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRD LINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMK RRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQP -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for RAPGEF5-STK4 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RAPGEF5-STK4 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RAPGEF5-STK4 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RAPGEF5 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | RAPGEF5 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Hgene | RAPGEF5 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
Hgene | RAPGEF5 | C0236804 | Amphetamine Addiction | 1 | CTD_human |
Hgene | RAPGEF5 | C0236807 | Amphetamine Abuse | 1 | CTD_human |
Hgene | RAPGEF5 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Tgene | C3553943 | T-CELL IMMUNODEFICIENCY, RECURRENT INFECTIONS, AND AUTOIMMUNITY WITH OR WITHOUT CARDIAC MALFORMATIONS | 2 | CTD_human;GENOMICS_ENGLAND;ORPHANET | |
Tgene | C4016913 | T-CELL IMMUNODEFICIENCY, RECURRENT INFECTIONS, AUTOIMMUNITY, AND CARDIAC MALFORMATIONS | 2 | GENOMICS_ENGLAND | |
Tgene | C0005586 | Bipolar Disorder | 1 | CTD_human | |
Tgene | C0005587 | Depression, Bipolar | 1 | CTD_human | |
Tgene | C0024713 | Manic Disorder | 1 | CTD_human | |
Tgene | C0338831 | Manic | 1 | CTD_human | |
Tgene | C0494261 | Combined immunodeficiency | 1 | GENOMICS_ENGLAND |