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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDC25B-CDC25B (FusionGDB2 ID:HG994TG994)

Fusion Gene Summary for CDC25B-CDC25B

check button Fusion gene summary
Fusion gene informationFusion gene name: CDC25B-CDC25B
Fusion gene ID: hg994tg994
HgeneTgene
Gene symbol

CDC25B

CDC25B

Gene ID

994

994

Gene namecell division cycle 25Bcell division cycle 25B
Synonyms--
Cytomap('CDC25B')('CDC25B')

20p13

20p13

Type of geneprotein-codingprotein-coding
DescriptionM-phase inducer phosphatase 2dual specificity phosphatase Cdc25BM-phase inducer phosphatase 2dual specificity phosphatase Cdc25B
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000245960, ENST00000344256, 
ENST00000439880, ENST00000340833, 
ENST00000379598, ENST00000467519, 
ENST00000245960, ENST00000344256, 
ENST00000439880, ENST00000340833, 
ENST00000379598, ENST00000467519, 
Fusion gene scores* DoF score1 X 3 X 1=32 X 4 X 2=16
# samples 34
** MAII scorelog2(3/3*10)=3.32192809488736log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CDC25B [Title/Abstract] AND CDC25B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDC25B(3786298)-CDC25B(3786398), # samples:1
CDC25B(3785904)-CDC25B(3785902), # samples:1
CDC25B(3785902)-CDC25B(3785983), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDC25B

GO:0006468

protein phosphorylation

17332740

TgeneCDC25B

GO:0006468

protein phosphorylation

17332740



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF205766CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
ChiTaRS5.0N/ABM666733CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
ChiTaRS5.0N/ABM702428CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+


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Fusion Gene ORF analysis for CDC25B-CDC25B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000245960ENST00000245960CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
3UTR-3UTRENST00000245960ENST00000245960CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
3UTR-3UTRENST00000245960ENST00000245960CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
3UTR-3UTRENST00000245960ENST00000344256CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
3UTR-3UTRENST00000245960ENST00000344256CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
3UTR-3UTRENST00000245960ENST00000439880CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
3UTR-3UTRENST00000245960ENST00000439880CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
3UTR-3UTRENST00000245960ENST00000439880CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
3UTR-3UTRENST00000344256ENST00000245960CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
3UTR-3UTRENST00000344256ENST00000245960CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
3UTR-3UTRENST00000344256ENST00000344256CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
3UTR-3UTRENST00000344256ENST00000344256CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
3UTR-3UTRENST00000344256ENST00000439880CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
3UTR-3UTRENST00000344256ENST00000439880CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
3UTR-3UTRENST00000439880ENST00000245960CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
3UTR-3UTRENST00000439880ENST00000245960CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
3UTR-3UTRENST00000439880ENST00000245960CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
3UTR-3UTRENST00000439880ENST00000344256CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
3UTR-3UTRENST00000439880ENST00000344256CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
3UTR-3UTRENST00000439880ENST00000439880CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
3UTR-3UTRENST00000439880ENST00000439880CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
3UTR-3UTRENST00000439880ENST00000439880CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
3UTR-intronENST00000245960ENST00000340833CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
3UTR-intronENST00000245960ENST00000340833CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
3UTR-intronENST00000245960ENST00000340833CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
3UTR-intronENST00000245960ENST00000344256CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
3UTR-intronENST00000245960ENST00000379598CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
3UTR-intronENST00000245960ENST00000379598CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
3UTR-intronENST00000245960ENST00000379598CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
3UTR-intronENST00000245960ENST00000467519CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
3UTR-intronENST00000245960ENST00000467519CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
3UTR-intronENST00000245960ENST00000467519CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
3UTR-intronENST00000344256ENST00000340833CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
3UTR-intronENST00000344256ENST00000340833CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
3UTR-intronENST00000344256ENST00000379598CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
3UTR-intronENST00000344256ENST00000379598CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
3UTR-intronENST00000344256ENST00000467519CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
3UTR-intronENST00000344256ENST00000467519CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
3UTR-intronENST00000439880ENST00000340833CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
3UTR-intronENST00000439880ENST00000340833CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
3UTR-intronENST00000439880ENST00000340833CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
3UTR-intronENST00000439880ENST00000344256CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
3UTR-intronENST00000439880ENST00000379598CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
3UTR-intronENST00000439880ENST00000379598CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
3UTR-intronENST00000439880ENST00000379598CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
3UTR-intronENST00000439880ENST00000467519CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
3UTR-intronENST00000439880ENST00000467519CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
3UTR-intronENST00000439880ENST00000467519CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
intron-3UTRENST00000340833ENST00000245960CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-3UTRENST00000340833ENST00000245960CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
intron-3UTRENST00000340833ENST00000245960CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
intron-3UTRENST00000340833ENST00000344256CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
intron-3UTRENST00000340833ENST00000344256CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
intron-3UTRENST00000340833ENST00000439880CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-3UTRENST00000340833ENST00000439880CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
intron-3UTRENST00000340833ENST00000439880CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
intron-3UTRENST00000344256ENST00000245960CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-3UTRENST00000344256ENST00000439880CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-3UTRENST00000379598ENST00000245960CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-3UTRENST00000379598ENST00000245960CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
intron-3UTRENST00000379598ENST00000245960CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
intron-3UTRENST00000379598ENST00000344256CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
intron-3UTRENST00000379598ENST00000344256CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
intron-3UTRENST00000379598ENST00000439880CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-3UTRENST00000379598ENST00000439880CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
intron-3UTRENST00000379598ENST00000439880CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
intron-3UTRENST00000467519ENST00000245960CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-3UTRENST00000467519ENST00000245960CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
intron-3UTRENST00000467519ENST00000245960CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
intron-3UTRENST00000467519ENST00000344256CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
intron-3UTRENST00000467519ENST00000344256CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
intron-3UTRENST00000467519ENST00000439880CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-3UTRENST00000467519ENST00000439880CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
intron-3UTRENST00000467519ENST00000439880CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
intron-intronENST00000340833ENST00000340833CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-intronENST00000340833ENST00000340833CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
intron-intronENST00000340833ENST00000340833CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
intron-intronENST00000340833ENST00000344256CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-intronENST00000340833ENST00000379598CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-intronENST00000340833ENST00000379598CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
intron-intronENST00000340833ENST00000379598CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
intron-intronENST00000340833ENST00000467519CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-intronENST00000340833ENST00000467519CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
intron-intronENST00000340833ENST00000467519CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
intron-intronENST00000344256ENST00000340833CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-intronENST00000344256ENST00000344256CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-intronENST00000344256ENST00000379598CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-intronENST00000344256ENST00000467519CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-intronENST00000379598ENST00000340833CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-intronENST00000379598ENST00000340833CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
intron-intronENST00000379598ENST00000340833CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
intron-intronENST00000379598ENST00000344256CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-intronENST00000379598ENST00000379598CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-intronENST00000379598ENST00000379598CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
intron-intronENST00000379598ENST00000379598CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
intron-intronENST00000379598ENST00000467519CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-intronENST00000379598ENST00000467519CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
intron-intronENST00000379598ENST00000467519CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
intron-intronENST00000467519ENST00000340833CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-intronENST00000467519ENST00000340833CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
intron-intronENST00000467519ENST00000340833CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
intron-intronENST00000467519ENST00000344256CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-intronENST00000467519ENST00000379598CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-intronENST00000467519ENST00000379598CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
intron-intronENST00000467519ENST00000379598CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+
intron-intronENST00000467519ENST00000467519CDC25Bchr20

3786298

-CDC25Bchr20

3786398

+
intron-intronENST00000467519ENST00000467519CDC25Bchr20

3785904

-CDC25Bchr20

3785902

+
intron-intronENST00000467519ENST00000467519CDC25Bchr20

3785902

-CDC25Bchr20

3785983

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CDC25B-CDC25B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for CDC25B-CDC25B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:3786298/:3786398)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CDC25B-CDC25B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CDC25B-CDC25B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDC25B-CDC25B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDC25B-CDC25B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDC25BC0019193Hepatitis, Toxic1CTD_human
HgeneCDC25BC0860207Drug-Induced Liver Disease1CTD_human
HgeneCDC25BC1135196Heart Failure, Diastolic1CTD_human
HgeneCDC25BC1262760Hepatitis, Drug-Induced1CTD_human
HgeneCDC25BC3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneCDC25BC4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneCDC25BC4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC1135196Heart Failure, Diastolic1CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human