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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP4R1-DPP4 (FusionGDB2 ID:HG9989TG1803)

Fusion Gene Summary for PPP4R1-DPP4

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP4R1-DPP4
Fusion gene ID: hg9989tg1803
HgeneTgene
Gene symbol

PPP4R1

DPP4

Gene ID

9989

1803

Gene nameprotein phosphatase 4 regulatory subunit 1dipeptidyl peptidase 4
SynonymsMEG1|PP4(Rmeg)|PP4R1ADABP|ADCP2|CD26|DPPIV|TP103
Cytomap('PPP4R1')('DPP4')

18p11.22

2q24.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 4 regulatory subunit 1serine/threonine phosphatase 4dipeptidyl peptidase 4ADCP-2DPP IVT-cell activation antigen CD26adenosine deaminase complexing protein 2dipeptidyl peptidase IVdipeptidylpeptidase 4dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
Modification date2020031320200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000400555, ENST00000400556, 
ENST00000580583, 
Fusion gene scores* DoF score13 X 13 X 9=15214 X 4 X 2=32
# samples 145
** MAII scorelog2(14/1521*10)=-3.44152142077953
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PPP4R1 [Title/Abstract] AND DPP4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP4R1(9561978)-DPP4(162851882), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDPP4

GO:0001666

response to hypoxia

16670267

TgeneDPP4

GO:0006508

proteolysis

27198182

TgeneDPP4

GO:0008284

positive regulation of cell proliferation

17549790

TgeneDPP4

GO:0010716

negative regulation of extracellular matrix disassembly

16651416

TgeneDPP4

GO:0031295

T cell costimulation

10900005|17287217

TgeneDPP4

GO:0033632

regulation of cell-cell adhesion mediated by integrin

11772392

TgeneDPP4

GO:0042110

T cell activation

7594462

TgeneDPP4

GO:0043542

endothelial cell migration

16651416


check buttonFusion gene breakpoints across PPP4R1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DPP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-EY-A3L3-01APPP4R1chr18

9561978

-DPP4chr2

162851882

-
ChimerDB4UCECTCGA-EY-A3L3PPP4R1chr18

9561977

-DPP4chr2

162851882

-


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Fusion Gene ORF analysis for PPP4R1-DPP4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000400555ENST00000491591PPP4R1chr18

9561978

-DPP4chr2

162851882

-
5CDS-5UTRENST00000400555ENST00000491591PPP4R1chr18

9561977

-DPP4chr2

162851882

-
5CDS-5UTRENST00000400556ENST00000491591PPP4R1chr18

9561978

-DPP4chr2

162851882

-
5CDS-5UTRENST00000400556ENST00000491591PPP4R1chr18

9561977

-DPP4chr2

162851882

-
In-frameENST00000400555ENST00000360534PPP4R1chr18

9561978

-DPP4chr2

162851882

-
In-frameENST00000400555ENST00000360534PPP4R1chr18

9561977

-DPP4chr2

162851882

-
In-frameENST00000400556ENST00000360534PPP4R1chr18

9561978

-DPP4chr2

162851882

-
In-frameENST00000400556ENST00000360534PPP4R1chr18

9561977

-DPP4chr2

162851882

-
intron-3CDSENST00000580583ENST00000360534PPP4R1chr18

9561978

-DPP4chr2

162851882

-
intron-3CDSENST00000580583ENST00000360534PPP4R1chr18

9561977

-DPP4chr2

162851882

-
intron-5UTRENST00000580583ENST00000491591PPP4R1chr18

9561978

-DPP4chr2

162851882

-
intron-5UTRENST00000580583ENST00000491591PPP4R1chr18

9561977

-DPP4chr2

162851882

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000400556PPP4R1chr189561978-ENST00000360534DPP4chr2162851882-32071916742164696
ENST00000400555PPP4R1chr189561978-ENST00000360534DPP4chr2162851882-31671876852124679
ENST00000400556PPP4R1chr189561977-ENST00000360534DPP4chr2162851882-32071916742164696
ENST00000400555PPP4R1chr189561977-ENST00000360534DPP4chr2162851882-31671876852124679

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000400556ENST00000360534PPP4R1chr189561978-DPP4chr2162851882-0.0003852470.9996147
ENST00000400555ENST00000360534PPP4R1chr189561978-DPP4chr2162851882-0.0009300010.99907
ENST00000400556ENST00000360534PPP4R1chr189561977-DPP4chr2162851882-0.0003852470.9996147
ENST00000400555ENST00000360534PPP4R1chr189561977-DPP4chr2162851882-0.0009300010.99907

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Fusion Genomic Features for PPP4R1-DPP4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for PPP4R1-DPP4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:9561978/chr2:162851882)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320127_164597934.0RepeatNote=HEAT 5
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320168_206597934.0RepeatNote=HEAT 6
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-13201_25597934.0RepeatNote=HEAT 1
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320208_246597934.0RepeatNote=HEAT 7
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320248_285597934.0RepeatNote=HEAT 8
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-132026_63597934.0RepeatNote=HEAT 2
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320287_324597934.0RepeatNote=HEAT 9
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320505_542597934.0RepeatNote=HEAT 10
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-132065_81597934.0RepeatNote=HEAT 3
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-132082_119597934.0RepeatNote=HEAT 4
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320127_164614951.0RepeatNote=HEAT 5
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320168_206614951.0RepeatNote=HEAT 6
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-13201_25614951.0RepeatNote=HEAT 1
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320208_246614951.0RepeatNote=HEAT 7
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320248_285614951.0RepeatNote=HEAT 8
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-132026_63614951.0RepeatNote=HEAT 2
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320287_324614951.0RepeatNote=HEAT 9
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320505_542614951.0RepeatNote=HEAT 10
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320568_606614951.0RepeatNote=HEAT 11
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-132065_81614951.0RepeatNote=HEAT 3
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-132082_119614951.0RepeatNote=HEAT 4
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320127_164597934.0RepeatNote=HEAT 5
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320168_206597934.0RepeatNote=HEAT 6
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-13201_25597934.0RepeatNote=HEAT 1
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320208_246597934.0RepeatNote=HEAT 7
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320248_285597934.0RepeatNote=HEAT 8
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-132026_63597934.0RepeatNote=HEAT 2
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320287_324597934.0RepeatNote=HEAT 9
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320505_542597934.0RepeatNote=HEAT 10
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-132065_81597934.0RepeatNote=HEAT 3
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-132082_119597934.0RepeatNote=HEAT 4
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320127_164614951.0RepeatNote=HEAT 5
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320168_206614951.0RepeatNote=HEAT 6
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-13201_25614951.0RepeatNote=HEAT 1
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320208_246614951.0RepeatNote=HEAT 7
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320248_285614951.0RepeatNote=HEAT 8
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-132026_63614951.0RepeatNote=HEAT 2
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320287_324614951.0RepeatNote=HEAT 9
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320505_542614951.0RepeatNote=HEAT 10
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320568_606614951.0RepeatNote=HEAT 11
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-132065_81614951.0RepeatNote=HEAT 3
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-132082_119614951.0RepeatNote=HEAT 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320568_606597934.0RepeatNote=HEAT 11
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320698_734597934.0RepeatNote=HEAT 12
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320799_837597934.0RepeatNote=HEAT 13
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320861_898597934.0RepeatNote=HEAT 14
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320698_734614951.0RepeatNote=HEAT 12
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320799_837614951.0RepeatNote=HEAT 13
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320861_898614951.0RepeatNote=HEAT 14
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320568_606597934.0RepeatNote=HEAT 11
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320698_734597934.0RepeatNote=HEAT 12
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320799_837597934.0RepeatNote=HEAT 13
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320861_898597934.0RepeatNote=HEAT 14
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320698_734614951.0RepeatNote=HEAT 12
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320799_837614951.0RepeatNote=HEAT 13
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320861_898614951.0RepeatNote=HEAT 14
TgeneDPP4chr18:9561977chr2:162851882ENST0000036053422261_6684767.0Topological domainCytoplasmic
TgeneDPP4chr18:9561977chr2:162851882ENST00000360534222629_766684767.0Topological domainExtracellular
TgeneDPP4chr18:9561978chr2:162851882ENST0000036053422261_6684767.0Topological domainCytoplasmic
TgeneDPP4chr18:9561978chr2:162851882ENST00000360534222629_766684767.0Topological domainExtracellular
TgeneDPP4chr18:9561977chr2:162851882ENST0000036053422267_28684767.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneDPP4chr18:9561978chr2:162851882ENST0000036053422267_28684767.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for PPP4R1-DPP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68181_68181_1_PPP4R1-DPP4_PPP4R1_chr18_9561977_ENST00000400555_DPP4_chr2_162851882_ENST00000360534_length(transcript)=3167nt_BP=1876nt
GCGCGCGTCCACCGGCTCCCCGGCTCGCGCCGCTCCATGTAGCCCCGGCTCCCCGGGCGGCCGCGGAGGAGGGGGCGACCACAAGATGGC
GGACCTCTCGCTGCTTCAGGAGGACCTGCAGGAGGACGCAGACGGATCCCTGGACTTTGTCTCACAAGATGAAATGTTGACGCCCCTGGG
GAGATTGGACAAGTATGCTGCAAGTGAGAACATATTTAACAGACAAATGGTGGCCCGGAGTTTGCTCGATACCTTGAGGGAAGTCTGCGA
TGATGAAAGAGATTGTATTGCTGTTTTGGAAAGAATTAGCAGATTGGCCGATGATTCAGAACCAACTGTGAGAGCGGAGCTGATGGAACA
GGTGCCTCACATCGCACTGTTTTGTCAAGAAAACCGGCCTTCAATACCATATGCTTTTTCAAAATTCTTACTACCTATTGTGGTTAGATA
CCTTGCAGATCAGAATAATCAGGTGAGGAAAACAAGTCAGGCAGCTTTGCTGGCTCTGTTGGAGCAGGAGCTCATTGAACGATTTGATGT
GGAGACCAAAGTGTGCCCTGTCCTCATAGAGCTGACAGCCCCAGATAGCAATGATGATGTGAAAACAGAAGCTGTGGCTATAATGTGCAA
AATGGCTCCCATGGTTGGGAAGGATATTACAGAGCGTCTTATCCTCCCTAGGTTTTGTGAGATGTGCTGCGATTGCAGAATGTTTCACGT
TCGAAAGGTCTGTGCTGCCAATTTTGGAGATATTTGCAGTGTAGTTGGCCAGCAAGCTACTGAAGAAATGTTGCTGCCCAGATTTTTCCA
GCTTTGTTCTGATAATGTATGGGGAGTCCGAAAGGCTTGTGCTGAATGCTTCATGGCGGTTTCATGTGCAACATGTCAAGAAATCCGACG
GACCAAATTATCAGCACTTTTTATTAATTTGATCAGTGATCCTTCACGTTGGGTTCGCCAAGCAGCTTTTCAGTCTCTGGGACCTTTCAT
ATCTACTTTTGCTAATCCATCTAGCTCAGGCCAGTATTTTAAAGAAGAAAGCAAAAGTTCAGAAGAGATGTCAGTAGAAAACAAAAATAG
GACCAGAGATCAAGAAGCCCCAGAGGATGTACAAGTCAGGCCAGAGGATACTCCTTCAGATCTCAGTGTTAGTAATTCCAGTGTCATACT
GGAAAACACGATGGAAGACCATGCTGCTGAGGCATCCGGGAAGCCTCTAGGTGAAATTAGTGTTCCACTGGACAGCTCTTTACTTTGTAC
TTTGTCCTCAGAATCTCACCAGGAAGCAGCTAGTAATGAGAATGATAAAAAACCTGGTAACTACAAATCTATGTTACGACCAGAGGTTGG
CACCACTTCACAAGATTCAGCTCTCTTAGATCAGGAATTGTATAACTCCTTCCATTTCTGGAGGACTCCTCTTCCTGAAATAGATCTAGA
CATAGAGCTTGAACAGAACTCTGGGGGAAAACCCAGCCCAGAGGGACCAGAGGAAGAATCTGAGGGCCCTGTGCCCAGTTCTCCAAACAT
CACCATGGCCACCAGAAAGGAACTGGAAGAAATGATAGAAAATCTAGAGCCCCACATTGATGATCCAGATGTTAAAGCACAAGTGGAAGT
GCTGTCCGCTGCACTACGTGCTTCCAGCCTGGATGCACATGAAGAGACCATCAGTATAGAAAAGAGAAGTGATTTGCAAGATGAACTGGA
TATAAATGAGCTACCAAATTGTAAAATAAATCAAGAAGATTCTGTGCCTTTAATCAGCGATGCTGTTGAGAATATGGACTCCACTCTTCA
CTATATTCACAGCGATTCAGACTTGAGCAACAATAGCAGTTTTAGCCCTGATGAGGAAAGGAGAACTAAAGTACAAAATTCAACAGTCAT
GAGCAGAGCTGAAAATTTTAAACAAGTTGAGTACCTCCTTATTCATGGAACAGCAGATGATAACGTTCACTTTCAGCAGTCAGCTCAGAT
CTCCAAAGCCCTGGTCGATGTTGGAGTGGATTTCCAGGCAATGTGGTATACTGATGAAGACCATGGAATAGCTAGCAGCACAGCACACCA
ACATATATATACCCACATGAGCCACTTCATAAAACAATGTTTCTCTTTACCTTAGCACCTCAAAATACCATGCCATTTAAAGCTTATTAA
AACTCATTTTTGTTTTCATTATCTCAAAACTGCACTGTCAAGATGATGATGATCTTTAAAATACACACTCAAATCAAGAAACTTAAGGTT
ACCTTTGTTCCCAAATTTCATACCTATCATCTTAAGTAGGGACTTCTGTCTTCACAACAGATTATTACCTTACAGAAGTTTGAATTATCC
GGTCGGGTTTTATTGTTTAAAATCATTTCTGCATCAGCTGCTGAAACAACAAATAGGAATTGTTTTTATGGAGGCTTTGCATAGATTCCC
TGAGCAGGATTTTAATCTTTTTCTAACTGGACTGGTTCAAATGTTGTTCTCTTCTTTAAAGGGATGGCAAGATGTGGGCAGTGATGTCAC
TAGGGCAGGGACAGGATAAGAGGGATTAGGGAGAGAAGATAGCAGGGCATGGCTGGGAACCCAAGTCCAAGCATACCAACACGAGCAGGC
TACTGTCAGCTCCCCTCGGAGAAGAGCTGTTCACAGCCAGACTGGCACAGTTTTCTGAGAAAGACTATTCAAACAGTCTCAGGAAATCAA
ATATGCAAAGCACTGACTTCTAAGTAAAACCACAGCAGTTGAAAAGACTCCAAAGAAATGTAAGGGAAACTGCCAGCAACGCAGGCCCCC
AGGTGCCAGTTATGGCTATAGGTGCTACAAAAACACAGCAAGGGTGATGGGAAAGCATTGTAAATGTGCTTTTAAAAAAAAATACTGATG
TTCCTAGTGAAAGAGGCAGCTTGAAACTGAGATGTGAACACATCAGCTTGCCCTGTTAAAAGATGAAAATATTTGTATCACAAATCTTAA
CTTGAAGGAGTCCTTGCATCAATTTTTCTTATTTCATTTCTTTGAGTGTCTTAATTAAAAGAATATTTTAACTTCCTTGGACTCATTTTA
AAAAATGGAACATAAAATACAATGTTATGTATTATTATTCCCATTCTACATACTATGGAATTTCTCCCAGTCATTTAATAAATGTGCCTT

>68181_68181_1_PPP4R1-DPP4_PPP4R1_chr18_9561977_ENST00000400555_DPP4_chr2_162851882_ENST00000360534_length(amino acids)=679AA_BP=596
MADLSLLQEDLQEDADGSLDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELM
EQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSNDDVKTEAVAIM
CKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEI
RRTKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQVRPEDTPSDLSVSNSSV
ILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEID
LDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLDAHEETISIEKRSDLQDE
LDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSA

--------------------------------------------------------------
>68181_68181_2_PPP4R1-DPP4_PPP4R1_chr18_9561977_ENST00000400556_DPP4_chr2_162851882_ENST00000360534_length(transcript)=3207nt_BP=1916nt
CCGGCTCCCCGGCTCGCGCCGCTCCATGTAGCCCCGGCTCCCCGGGCGGCCGCGGAGGAGGGGGCGACCACAAGATGGCGGACCTCTCGC
TGCTTCAGGAGGACCTGCAGGAGGACGCAGACGGATTTGGTGTGGATGACTACAGCTCAGAGTCTGATGTGATTATTATACCTTCAGCCC
TGGACTTTGTCTCACAAGATGAAATGTTGACGCCCCTGGGGAGATTGGACAAGTATGCTGCAAGTGAGAACATATTTAACAGACAAATGG
TGGCCCGGAGTTTGCTCGATACCTTGAGGGAAGTCTGCGATGATGAAAGAGATTGTATTGCTGTTTTGGAAAGAATTAGCAGATTGGCCG
ATGATTCAGAACCAACTGTGAGAGCGGAGCTGATGGAACAGGTGCCTCACATCGCACTGTTTTGTCAAGAAAACCGGCCTTCAATACCAT
ATGCTTTTTCAAAATTCTTACTACCTATTGTGGTTAGATACCTTGCAGATCAGAATAATCAGGTGAGGAAAACAAGTCAGGCAGCTTTGC
TGGCTCTGTTGGAGCAGGAGCTCATTGAACGATTTGATGTGGAGACCAAAGTGTGCCCTGTCCTCATAGAGCTGACAGCCCCAGATAGCA
ATGATGATGTGAAAACAGAAGCTGTGGCTATAATGTGCAAAATGGCTCCCATGGTTGGGAAGGATATTACAGAGCGTCTTATCCTCCCTA
GGTTTTGTGAGATGTGCTGCGATTGCAGAATGTTTCACGTTCGAAAGGTCTGTGCTGCCAATTTTGGAGATATTTGCAGTGTAGTTGGCC
AGCAAGCTACTGAAGAAATGTTGCTGCCCAGATTTTTCCAGCTTTGTTCTGATAATGTATGGGGAGTCCGAAAGGCTTGTGCTGAATGCT
TCATGGCGGTTTCATGTGCAACATGTCAAGAAATCCGACGGACCAAATTATCAGCACTTTTTATTAATTTGATCAGTGATCCTTCACGTT
GGGTTCGCCAAGCAGCTTTTCAGTCTCTGGGACCTTTCATATCTACTTTTGCTAATCCATCTAGCTCAGGCCAGTATTTTAAAGAAGAAA
GCAAAAGTTCAGAAGAGATGTCAGTAGAAAACAAAAATAGGACCAGAGATCAAGAAGCCCCAGAGGATGTACAAGTCAGGCCAGAGGATA
CTCCTTCAGATCTCAGTGTTAGTAATTCCAGTGTCATACTGGAAAACACGATGGAAGACCATGCTGCTGAGGCATCCGGGAAGCCTCTAG
GTGAAATTAGTGTTCCACTGGACAGCTCTTTACTTTGTACTTTGTCCTCAGAATCTCACCAGGAAGCAGCTAGTAATGAGAATGATAAAA
AACCTGGTAACTACAAATCTATGTTACGACCAGAGGTTGGCACCACTTCACAAGATTCAGCTCTCTTAGATCAGGAATTGTATAACTCCT
TCCATTTCTGGAGGACTCCTCTTCCTGAAATAGATCTAGACATAGAGCTTGAACAGAACTCTGGGGGAAAACCCAGCCCAGAGGGACCAG
AGGAAGAATCTGAGGGCCCTGTGCCCAGTTCTCCAAACATCACCATGGCCACCAGAAAGGAACTGGAAGAAATGATAGAAAATCTAGAGC
CCCACATTGATGATCCAGATGTTAAAGCACAAGTGGAAGTGCTGTCCGCTGCACTACGTGCTTCCAGCCTGGATGCACATGAAGAGACCA
TCAGTATAGAAAAGAGAAGTGATTTGCAAGATGAACTGGATATAAATGAGCTACCAAATTGTAAAATAAATCAAGAAGATTCTGTGCCTT
TAATCAGCGATGCTGTTGAGAATATGGACTCCACTCTTCACTATATTCACAGCGATTCAGACTTGAGCAACAATAGCAGTTTTAGCCCTG
ATGAGGAAAGGAGAACTAAAGTACAAAATTCAACAGTCATGAGCAGAGCTGAAAATTTTAAACAAGTTGAGTACCTCCTTATTCATGGAA
CAGCAGATGATAACGTTCACTTTCAGCAGTCAGCTCAGATCTCCAAAGCCCTGGTCGATGTTGGAGTGGATTTCCAGGCAATGTGGTATA
CTGATGAAGACCATGGAATAGCTAGCAGCACAGCACACCAACATATATATACCCACATGAGCCACTTCATAAAACAATGTTTCTCTTTAC
CTTAGCACCTCAAAATACCATGCCATTTAAAGCTTATTAAAACTCATTTTTGTTTTCATTATCTCAAAACTGCACTGTCAAGATGATGAT
GATCTTTAAAATACACACTCAAATCAAGAAACTTAAGGTTACCTTTGTTCCCAAATTTCATACCTATCATCTTAAGTAGGGACTTCTGTC
TTCACAACAGATTATTACCTTACAGAAGTTTGAATTATCCGGTCGGGTTTTATTGTTTAAAATCATTTCTGCATCAGCTGCTGAAACAAC
AAATAGGAATTGTTTTTATGGAGGCTTTGCATAGATTCCCTGAGCAGGATTTTAATCTTTTTCTAACTGGACTGGTTCAAATGTTGTTCT
CTTCTTTAAAGGGATGGCAAGATGTGGGCAGTGATGTCACTAGGGCAGGGACAGGATAAGAGGGATTAGGGAGAGAAGATAGCAGGGCAT
GGCTGGGAACCCAAGTCCAAGCATACCAACACGAGCAGGCTACTGTCAGCTCCCCTCGGAGAAGAGCTGTTCACAGCCAGACTGGCACAG
TTTTCTGAGAAAGACTATTCAAACAGTCTCAGGAAATCAAATATGCAAAGCACTGACTTCTAAGTAAAACCACAGCAGTTGAAAAGACTC
CAAAGAAATGTAAGGGAAACTGCCAGCAACGCAGGCCCCCAGGTGCCAGTTATGGCTATAGGTGCTACAAAAACACAGCAAGGGTGATGG
GAAAGCATTGTAAATGTGCTTTTAAAAAAAAATACTGATGTTCCTAGTGAAAGAGGCAGCTTGAAACTGAGATGTGAACACATCAGCTTG
CCCTGTTAAAAGATGAAAATATTTGTATCACAAATCTTAACTTGAAGGAGTCCTTGCATCAATTTTTCTTATTTCATTTCTTTGAGTGTC
TTAATTAAAAGAATATTTTAACTTCCTTGGACTCATTTTAAAAAATGGAACATAAAATACAATGTTATGTATTATTATTCCCATTCTACA

>68181_68181_2_PPP4R1-DPP4_PPP4R1_chr18_9561977_ENST00000400556_DPP4_chr2_162851882_ENST00000360534_length(amino acids)=696AA_BP=613
MADLSLLQEDLQEDADGFGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLER
ISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIEL
TAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRK
ACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQ
VRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQ
ELYNSFHFWRTPLPEIDLDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLD
AHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQNSTVMSRAENFKQVEY

--------------------------------------------------------------
>68181_68181_3_PPP4R1-DPP4_PPP4R1_chr18_9561978_ENST00000400555_DPP4_chr2_162851882_ENST00000360534_length(transcript)=3167nt_BP=1876nt
GCGCGCGTCCACCGGCTCCCCGGCTCGCGCCGCTCCATGTAGCCCCGGCTCCCCGGGCGGCCGCGGAGGAGGGGGCGACCACAAGATGGC
GGACCTCTCGCTGCTTCAGGAGGACCTGCAGGAGGACGCAGACGGATCCCTGGACTTTGTCTCACAAGATGAAATGTTGACGCCCCTGGG
GAGATTGGACAAGTATGCTGCAAGTGAGAACATATTTAACAGACAAATGGTGGCCCGGAGTTTGCTCGATACCTTGAGGGAAGTCTGCGA
TGATGAAAGAGATTGTATTGCTGTTTTGGAAAGAATTAGCAGATTGGCCGATGATTCAGAACCAACTGTGAGAGCGGAGCTGATGGAACA
GGTGCCTCACATCGCACTGTTTTGTCAAGAAAACCGGCCTTCAATACCATATGCTTTTTCAAAATTCTTACTACCTATTGTGGTTAGATA
CCTTGCAGATCAGAATAATCAGGTGAGGAAAACAAGTCAGGCAGCTTTGCTGGCTCTGTTGGAGCAGGAGCTCATTGAACGATTTGATGT
GGAGACCAAAGTGTGCCCTGTCCTCATAGAGCTGACAGCCCCAGATAGCAATGATGATGTGAAAACAGAAGCTGTGGCTATAATGTGCAA
AATGGCTCCCATGGTTGGGAAGGATATTACAGAGCGTCTTATCCTCCCTAGGTTTTGTGAGATGTGCTGCGATTGCAGAATGTTTCACGT
TCGAAAGGTCTGTGCTGCCAATTTTGGAGATATTTGCAGTGTAGTTGGCCAGCAAGCTACTGAAGAAATGTTGCTGCCCAGATTTTTCCA
GCTTTGTTCTGATAATGTATGGGGAGTCCGAAAGGCTTGTGCTGAATGCTTCATGGCGGTTTCATGTGCAACATGTCAAGAAATCCGACG
GACCAAATTATCAGCACTTTTTATTAATTTGATCAGTGATCCTTCACGTTGGGTTCGCCAAGCAGCTTTTCAGTCTCTGGGACCTTTCAT
ATCTACTTTTGCTAATCCATCTAGCTCAGGCCAGTATTTTAAAGAAGAAAGCAAAAGTTCAGAAGAGATGTCAGTAGAAAACAAAAATAG
GACCAGAGATCAAGAAGCCCCAGAGGATGTACAAGTCAGGCCAGAGGATACTCCTTCAGATCTCAGTGTTAGTAATTCCAGTGTCATACT
GGAAAACACGATGGAAGACCATGCTGCTGAGGCATCCGGGAAGCCTCTAGGTGAAATTAGTGTTCCACTGGACAGCTCTTTACTTTGTAC
TTTGTCCTCAGAATCTCACCAGGAAGCAGCTAGTAATGAGAATGATAAAAAACCTGGTAACTACAAATCTATGTTACGACCAGAGGTTGG
CACCACTTCACAAGATTCAGCTCTCTTAGATCAGGAATTGTATAACTCCTTCCATTTCTGGAGGACTCCTCTTCCTGAAATAGATCTAGA
CATAGAGCTTGAACAGAACTCTGGGGGAAAACCCAGCCCAGAGGGACCAGAGGAAGAATCTGAGGGCCCTGTGCCCAGTTCTCCAAACAT
CACCATGGCCACCAGAAAGGAACTGGAAGAAATGATAGAAAATCTAGAGCCCCACATTGATGATCCAGATGTTAAAGCACAAGTGGAAGT
GCTGTCCGCTGCACTACGTGCTTCCAGCCTGGATGCACATGAAGAGACCATCAGTATAGAAAAGAGAAGTGATTTGCAAGATGAACTGGA
TATAAATGAGCTACCAAATTGTAAAATAAATCAAGAAGATTCTGTGCCTTTAATCAGCGATGCTGTTGAGAATATGGACTCCACTCTTCA
CTATATTCACAGCGATTCAGACTTGAGCAACAATAGCAGTTTTAGCCCTGATGAGGAAAGGAGAACTAAAGTACAAAATTCAACAGTCAT
GAGCAGAGCTGAAAATTTTAAACAAGTTGAGTACCTCCTTATTCATGGAACAGCAGATGATAACGTTCACTTTCAGCAGTCAGCTCAGAT
CTCCAAAGCCCTGGTCGATGTTGGAGTGGATTTCCAGGCAATGTGGTATACTGATGAAGACCATGGAATAGCTAGCAGCACAGCACACCA
ACATATATATACCCACATGAGCCACTTCATAAAACAATGTTTCTCTTTACCTTAGCACCTCAAAATACCATGCCATTTAAAGCTTATTAA
AACTCATTTTTGTTTTCATTATCTCAAAACTGCACTGTCAAGATGATGATGATCTTTAAAATACACACTCAAATCAAGAAACTTAAGGTT
ACCTTTGTTCCCAAATTTCATACCTATCATCTTAAGTAGGGACTTCTGTCTTCACAACAGATTATTACCTTACAGAAGTTTGAATTATCC
GGTCGGGTTTTATTGTTTAAAATCATTTCTGCATCAGCTGCTGAAACAACAAATAGGAATTGTTTTTATGGAGGCTTTGCATAGATTCCC
TGAGCAGGATTTTAATCTTTTTCTAACTGGACTGGTTCAAATGTTGTTCTCTTCTTTAAAGGGATGGCAAGATGTGGGCAGTGATGTCAC
TAGGGCAGGGACAGGATAAGAGGGATTAGGGAGAGAAGATAGCAGGGCATGGCTGGGAACCCAAGTCCAAGCATACCAACACGAGCAGGC
TACTGTCAGCTCCCCTCGGAGAAGAGCTGTTCACAGCCAGACTGGCACAGTTTTCTGAGAAAGACTATTCAAACAGTCTCAGGAAATCAA
ATATGCAAAGCACTGACTTCTAAGTAAAACCACAGCAGTTGAAAAGACTCCAAAGAAATGTAAGGGAAACTGCCAGCAACGCAGGCCCCC
AGGTGCCAGTTATGGCTATAGGTGCTACAAAAACACAGCAAGGGTGATGGGAAAGCATTGTAAATGTGCTTTTAAAAAAAAATACTGATG
TTCCTAGTGAAAGAGGCAGCTTGAAACTGAGATGTGAACACATCAGCTTGCCCTGTTAAAAGATGAAAATATTTGTATCACAAATCTTAA
CTTGAAGGAGTCCTTGCATCAATTTTTCTTATTTCATTTCTTTGAGTGTCTTAATTAAAAGAATATTTTAACTTCCTTGGACTCATTTTA
AAAAATGGAACATAAAATACAATGTTATGTATTATTATTCCCATTCTACATACTATGGAATTTCTCCCAGTCATTTAATAAATGTGCCTT

>68181_68181_3_PPP4R1-DPP4_PPP4R1_chr18_9561978_ENST00000400555_DPP4_chr2_162851882_ENST00000360534_length(amino acids)=679AA_BP=596
MADLSLLQEDLQEDADGSLDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELM
EQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSNDDVKTEAVAIM
CKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEI
RRTKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQVRPEDTPSDLSVSNSSV
ILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEID
LDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLDAHEETISIEKRSDLQDE
LDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSA

--------------------------------------------------------------
>68181_68181_4_PPP4R1-DPP4_PPP4R1_chr18_9561978_ENST00000400556_DPP4_chr2_162851882_ENST00000360534_length(transcript)=3207nt_BP=1916nt
CCGGCTCCCCGGCTCGCGCCGCTCCATGTAGCCCCGGCTCCCCGGGCGGCCGCGGAGGAGGGGGCGACCACAAGATGGCGGACCTCTCGC
TGCTTCAGGAGGACCTGCAGGAGGACGCAGACGGATTTGGTGTGGATGACTACAGCTCAGAGTCTGATGTGATTATTATACCTTCAGCCC
TGGACTTTGTCTCACAAGATGAAATGTTGACGCCCCTGGGGAGATTGGACAAGTATGCTGCAAGTGAGAACATATTTAACAGACAAATGG
TGGCCCGGAGTTTGCTCGATACCTTGAGGGAAGTCTGCGATGATGAAAGAGATTGTATTGCTGTTTTGGAAAGAATTAGCAGATTGGCCG
ATGATTCAGAACCAACTGTGAGAGCGGAGCTGATGGAACAGGTGCCTCACATCGCACTGTTTTGTCAAGAAAACCGGCCTTCAATACCAT
ATGCTTTTTCAAAATTCTTACTACCTATTGTGGTTAGATACCTTGCAGATCAGAATAATCAGGTGAGGAAAACAAGTCAGGCAGCTTTGC
TGGCTCTGTTGGAGCAGGAGCTCATTGAACGATTTGATGTGGAGACCAAAGTGTGCCCTGTCCTCATAGAGCTGACAGCCCCAGATAGCA
ATGATGATGTGAAAACAGAAGCTGTGGCTATAATGTGCAAAATGGCTCCCATGGTTGGGAAGGATATTACAGAGCGTCTTATCCTCCCTA
GGTTTTGTGAGATGTGCTGCGATTGCAGAATGTTTCACGTTCGAAAGGTCTGTGCTGCCAATTTTGGAGATATTTGCAGTGTAGTTGGCC
AGCAAGCTACTGAAGAAATGTTGCTGCCCAGATTTTTCCAGCTTTGTTCTGATAATGTATGGGGAGTCCGAAAGGCTTGTGCTGAATGCT
TCATGGCGGTTTCATGTGCAACATGTCAAGAAATCCGACGGACCAAATTATCAGCACTTTTTATTAATTTGATCAGTGATCCTTCACGTT
GGGTTCGCCAAGCAGCTTTTCAGTCTCTGGGACCTTTCATATCTACTTTTGCTAATCCATCTAGCTCAGGCCAGTATTTTAAAGAAGAAA
GCAAAAGTTCAGAAGAGATGTCAGTAGAAAACAAAAATAGGACCAGAGATCAAGAAGCCCCAGAGGATGTACAAGTCAGGCCAGAGGATA
CTCCTTCAGATCTCAGTGTTAGTAATTCCAGTGTCATACTGGAAAACACGATGGAAGACCATGCTGCTGAGGCATCCGGGAAGCCTCTAG
GTGAAATTAGTGTTCCACTGGACAGCTCTTTACTTTGTACTTTGTCCTCAGAATCTCACCAGGAAGCAGCTAGTAATGAGAATGATAAAA
AACCTGGTAACTACAAATCTATGTTACGACCAGAGGTTGGCACCACTTCACAAGATTCAGCTCTCTTAGATCAGGAATTGTATAACTCCT
TCCATTTCTGGAGGACTCCTCTTCCTGAAATAGATCTAGACATAGAGCTTGAACAGAACTCTGGGGGAAAACCCAGCCCAGAGGGACCAG
AGGAAGAATCTGAGGGCCCTGTGCCCAGTTCTCCAAACATCACCATGGCCACCAGAAAGGAACTGGAAGAAATGATAGAAAATCTAGAGC
CCCACATTGATGATCCAGATGTTAAAGCACAAGTGGAAGTGCTGTCCGCTGCACTACGTGCTTCCAGCCTGGATGCACATGAAGAGACCA
TCAGTATAGAAAAGAGAAGTGATTTGCAAGATGAACTGGATATAAATGAGCTACCAAATTGTAAAATAAATCAAGAAGATTCTGTGCCTT
TAATCAGCGATGCTGTTGAGAATATGGACTCCACTCTTCACTATATTCACAGCGATTCAGACTTGAGCAACAATAGCAGTTTTAGCCCTG
ATGAGGAAAGGAGAACTAAAGTACAAAATTCAACAGTCATGAGCAGAGCTGAAAATTTTAAACAAGTTGAGTACCTCCTTATTCATGGAA
CAGCAGATGATAACGTTCACTTTCAGCAGTCAGCTCAGATCTCCAAAGCCCTGGTCGATGTTGGAGTGGATTTCCAGGCAATGTGGTATA
CTGATGAAGACCATGGAATAGCTAGCAGCACAGCACACCAACATATATATACCCACATGAGCCACTTCATAAAACAATGTTTCTCTTTAC
CTTAGCACCTCAAAATACCATGCCATTTAAAGCTTATTAAAACTCATTTTTGTTTTCATTATCTCAAAACTGCACTGTCAAGATGATGAT
GATCTTTAAAATACACACTCAAATCAAGAAACTTAAGGTTACCTTTGTTCCCAAATTTCATACCTATCATCTTAAGTAGGGACTTCTGTC
TTCACAACAGATTATTACCTTACAGAAGTTTGAATTATCCGGTCGGGTTTTATTGTTTAAAATCATTTCTGCATCAGCTGCTGAAACAAC
AAATAGGAATTGTTTTTATGGAGGCTTTGCATAGATTCCCTGAGCAGGATTTTAATCTTTTTCTAACTGGACTGGTTCAAATGTTGTTCT
CTTCTTTAAAGGGATGGCAAGATGTGGGCAGTGATGTCACTAGGGCAGGGACAGGATAAGAGGGATTAGGGAGAGAAGATAGCAGGGCAT
GGCTGGGAACCCAAGTCCAAGCATACCAACACGAGCAGGCTACTGTCAGCTCCCCTCGGAGAAGAGCTGTTCACAGCCAGACTGGCACAG
TTTTCTGAGAAAGACTATTCAAACAGTCTCAGGAAATCAAATATGCAAAGCACTGACTTCTAAGTAAAACCACAGCAGTTGAAAAGACTC
CAAAGAAATGTAAGGGAAACTGCCAGCAACGCAGGCCCCCAGGTGCCAGTTATGGCTATAGGTGCTACAAAAACACAGCAAGGGTGATGG
GAAAGCATTGTAAATGTGCTTTTAAAAAAAAATACTGATGTTCCTAGTGAAAGAGGCAGCTTGAAACTGAGATGTGAACACATCAGCTTG
CCCTGTTAAAAGATGAAAATATTTGTATCACAAATCTTAACTTGAAGGAGTCCTTGCATCAATTTTTCTTATTTCATTTCTTTGAGTGTC
TTAATTAAAAGAATATTTTAACTTCCTTGGACTCATTTTAAAAAATGGAACATAAAATACAATGTTATGTATTATTATTCCCATTCTACA

>68181_68181_4_PPP4R1-DPP4_PPP4R1_chr18_9561978_ENST00000400556_DPP4_chr2_162851882_ENST00000360534_length(amino acids)=696AA_BP=613
MADLSLLQEDLQEDADGFGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLER
ISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIEL
TAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRK
ACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQ
VRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQ
ELYNSFHFWRTPLPEIDLDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLD
AHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQNSTVMSRAENFKQVEY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPP4R1-DPP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP4R1-DPP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP4R1-DPP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0011570Mental Depression2PSYGENET
TgeneC0011581Depressive disorder2PSYGENET
TgeneC0033687Proteinuria1CTD_human