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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AKT3-SDCCAG8 (FusionGDB2 ID:HG10000TG10806)

Fusion Gene Summary for AKT3-SDCCAG8

check button Fusion gene summary
Fusion gene informationFusion gene name: AKT3-SDCCAG8
Fusion gene ID: hg10000tg10806
HgeneTgene
Gene symbol

AKT3

SDCCAG8

Gene ID

10000

10806

Gene nameAKT serine/threonine kinase 3SHH signaling and ciliogenesis regulator SDCCAG8
SynonymsMPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2BBS16|CCCAP|CCCAP SLSN7|HSPC085|NPHP10|NY-CO-8|SLSN7|hCCCAP
Cytomap('AKT3')('SDCCAG8')

1q43-q44

1q43-q44

Type of geneprotein-codingprotein-coding
DescriptionRAC-gamma serine/threonine-protein kinasePKB gammaRAC-gamma serine/threonine protein kinasev-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)serologically defined colon cancer antigen 8Bardet-Biedl syndrome 16antigen NY-CO-8centrosomal colon cancer autoantigen proteinnephrocystin 10
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263826, ENST00000336199, 
ENST00000366539, ENST00000366540, 
ENST00000492957, 
Fusion gene scores* DoF score18 X 15 X 7=189022 X 19 X 10=4180
# samples 2126
** MAII scorelog2(21/1890*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/4180*10)=-4.00691941393979
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKT3 [Title/Abstract] AND SDCCAG8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKT3(243652316)-SDCCAG8(243652442), # samples:2
Anticipated loss of major functional domain due to fusion event.AKT3-SDCCAG8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-SDCCAG8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-SDCCAG8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-SDCCAG8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-SDCCAG8 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
AKT3-SDCCAG8 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
AKT3-SDCCAG8 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKT3

GO:0043536

positive regulation of blood vessel endothelial cell migration

28254819

HgeneAKT3

GO:1905564

positive regulation of vascular endothelial cell proliferation

28254819


check buttonFusion gene breakpoints across AKT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SDCCAG8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-IN-8462-11AAKT3chr1

243858893

-SDCCAG8chr1

243468015

+
ChiTaRS5.0N/AAX053494AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
ChiTaRS5.0N/ABD345482AKT3chr1

243652316

-SDCCAG8chr1

243652442

-


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Fusion Gene ORF analysis for AKT3-SDCCAG8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000263826ENST00000496361AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
5CDS-3UTRENST00000336199ENST00000496361AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
5CDS-3UTRENST00000366539ENST00000496361AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
5CDS-3UTRENST00000366540ENST00000496361AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
Frame-shiftENST00000263826ENST00000343783AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
Frame-shiftENST00000263826ENST00000355875AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
Frame-shiftENST00000263826ENST00000366541AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
Frame-shiftENST00000263826ENST00000391846AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
Frame-shiftENST00000366540ENST00000343783AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
Frame-shiftENST00000366540ENST00000355875AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
Frame-shiftENST00000366540ENST00000366541AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
Frame-shiftENST00000366540ENST00000391846AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
In-frameENST00000336199ENST00000343783AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
In-frameENST00000336199ENST00000355875AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
In-frameENST00000336199ENST00000366541AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
In-frameENST00000336199ENST00000391846AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
In-frameENST00000366539ENST00000343783AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
In-frameENST00000366539ENST00000355875AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
In-frameENST00000366539ENST00000366541AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
In-frameENST00000366539ENST00000391846AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
intron-3CDSENST00000492957ENST00000343783AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
intron-3CDSENST00000492957ENST00000355875AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
intron-3CDSENST00000492957ENST00000366541AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
intron-3CDSENST00000492957ENST00000391846AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
intron-3UTRENST00000492957ENST00000496361AKT3chr1

243858893

-SDCCAG8chr1

243468015

+
intron-intronENST00000263826ENST00000343783AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000263826ENST00000355875AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000263826ENST00000366541AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000263826ENST00000391846AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000263826ENST00000496361AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000336199ENST00000343783AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000336199ENST00000355875AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000336199ENST00000366541AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000336199ENST00000391846AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000336199ENST00000496361AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000366539ENST00000343783AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000366539ENST00000355875AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000366539ENST00000366541AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000366539ENST00000391846AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000366539ENST00000496361AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000366540ENST00000343783AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000366540ENST00000355875AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000366540ENST00000366541AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000366540ENST00000391846AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000366540ENST00000496361AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000492957ENST00000343783AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000492957ENST00000355875AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000492957ENST00000366541AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000492957ENST00000391846AKT3chr1

243652316

-SDCCAG8chr1

243652442

-
intron-intronENST00000492957ENST00000496361AKT3chr1

243652316

-SDCCAG8chr1

243652442

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336199AKT3chr1243858893-ENST00000355875SDCCAG8chr1243468015+20062381961704502
ENST00000336199AKT3chr1243858893-ENST00000366541SDCCAG8chr1243468015+20122381961704502
ENST00000336199AKT3chr1243858893-ENST00000343783SDCCAG8chr1243468015+20102381961704502
ENST00000336199AKT3chr1243858893-ENST00000391846SDCCAG8chr1243468015+646238196645150
ENST00000366539AKT3chr1243858893-ENST00000355875SDCCAG8chr1243468015+21413733311839502
ENST00000366539AKT3chr1243858893-ENST00000366541SDCCAG8chr1243468015+21473733311839502
ENST00000366539AKT3chr1243858893-ENST00000343783SDCCAG8chr1243468015+21453733311839502
ENST00000366539AKT3chr1243858893-ENST00000391846SDCCAG8chr1243468015+781373331780150

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336199ENST00000355875AKT3chr1243858893-SDCCAG8chr1243468015+0.0030274220.99697256
ENST00000336199ENST00000366541AKT3chr1243858893-SDCCAG8chr1243468015+0.0029969770.997003
ENST00000336199ENST00000343783AKT3chr1243858893-SDCCAG8chr1243468015+0.0029559850.997044
ENST00000336199ENST00000391846AKT3chr1243858893-SDCCAG8chr1243468015+0.0110882540.98891175
ENST00000366539ENST00000355875AKT3chr1243858893-SDCCAG8chr1243468015+0.0036805910.9963194
ENST00000366539ENST00000366541AKT3chr1243858893-SDCCAG8chr1243468015+0.0036398320.9963601
ENST00000366539ENST00000343783AKT3chr1243858893-SDCCAG8chr1243468015+0.0036080920.99639195
ENST00000366539ENST00000391846AKT3chr1243858893-SDCCAG8chr1243468015+0.0113528380.98864716

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Fusion Genomic Features for AKT3-SDCCAG8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AKT3chr1243858892-SDCCAG8chr1243468014+5.81E-050.99994195
AKT3chr1243858892-SDCCAG8chr1243468014+5.81E-050.99994195

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AKT3-SDCCAG8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:243652316/chr1:243652442)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSDCCAG8chr1:243858893chr1:243468015ENST00000366541518223_273225714.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:243858893chr1:243468015ENST00000366541518348_707225714.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:243858893chr1:243468015ENST00000391846510223_273225361.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:243858893chr1:243468015ENST00000391846510348_707225361.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:243858893chr1:243468015ENST00000366541518534_692225714.0Compositional biasNote=Gln-rich
TgeneSDCCAG8chr1:243858893chr1:243468015ENST00000391846510534_692225361.0Compositional biasNote=Gln-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKT3chr1:243858893chr1:243468015ENST00000263826-213148_40557480.0DomainProtein kinase
HgeneAKT3chr1:243858893chr1:243468015ENST00000263826-213406_47957480.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:243858893chr1:243468015ENST00000263826-2135_10757480.0DomainPH
HgeneAKT3chr1:243858893chr1:243468015ENST00000336199-214148_40557476.0DomainProtein kinase
HgeneAKT3chr1:243858893chr1:243468015ENST00000336199-214406_47957476.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:243858893chr1:243468015ENST00000336199-2145_10757476.0DomainPH
HgeneAKT3chr1:243858893chr1:243468015ENST00000366539-314148_40557480.0DomainProtein kinase
HgeneAKT3chr1:243858893chr1:243468015ENST00000366539-314406_47957480.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:243858893chr1:243468015ENST00000366539-3145_10757480.0DomainPH
HgeneAKT3chr1:243858893chr1:243468015ENST00000366540-314148_40557466.0DomainProtein kinase
HgeneAKT3chr1:243858893chr1:243468015ENST00000366540-314406_47957466.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:243858893chr1:243468015ENST00000366540-3145_10757466.0DomainPH
HgeneAKT3chr1:243858893chr1:243468015ENST00000263826-213154_16257480.0Nucleotide bindingATP
HgeneAKT3chr1:243858893chr1:243468015ENST00000336199-214154_16257476.0Nucleotide bindingATP
HgeneAKT3chr1:243858893chr1:243468015ENST00000366539-314154_16257480.0Nucleotide bindingATP
HgeneAKT3chr1:243858893chr1:243468015ENST00000366540-314154_16257466.0Nucleotide bindingATP
TgeneSDCCAG8chr1:243858893chr1:243468015ENST00000366541518129_175225714.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:243858893chr1:243468015ENST00000391846510129_175225361.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:243858893chr1:243468015ENST00000366541518216_713225714.0RegionSufficient for homodimerization
TgeneSDCCAG8chr1:243858893chr1:243468015ENST00000391846510216_713225361.0RegionSufficient for homodimerization


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Fusion Gene Sequence for AKT3-SDCCAG8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3507_3507_1_AKT3-SDCCAG8_AKT3_chr1_243858893_ENST00000336199_SDCCAG8_chr1_243468015_ENST00000343783_length(transcript)=2010nt_BP=238nt
CCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAA
GAAGGTTGGGTTCAGAAGAGGGGAGAATATATAAAAAACTGGAGGCCAAGATACTTCCTTTTGAAGACAGATGGCTCATTCATAGGATAT
AAAGAGAAACCTCAAGATGTGGATTTACCTTATCCCCTCAACAACTTTTCAGTGGCAAGAGAAGCTAAAACTTACTTATGAGGAAAAGTG
TGAAATTGAGGAATCCCAATTGAAGTTTTTGAGGAACGACTTAGCTGAATATCAGAGAACTTGTGAAGATCTTAAAGAGCAACTAAAGCA
TAAAGAATTTCTTCTGGCTGCTAATACTTGTAACCGTGTTGGTGGTCTTTGTTTGAAATGTGCTCAGCATGAAGCTGTTCTTTCCCAAAC
CCATACTAATGTTCATATGCAGACCATCGAAAGACTGGTTAAAGAAAGAGATGACTTGATGTCTGCACTAGTTTCCGTAAGGAGCAGCTT
GGCAGATACGCAGCAAAGAGAAGCAAGTGCTTATGAACAGGTGAAACAAGTTTTGCAAATATCTGAGGAAGCCAATTTTGAAAAAACCAA
GGCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAG
GGCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGC
CCAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCG
GGAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAG
AGAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACA
CTTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCA
CCTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGA
GCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTT
GACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCA
AGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACA
TGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCA
GCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGG
ATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCC
AGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGA
CTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACA

>3507_3507_1_AKT3-SDCCAG8_AKT3_chr1_243858893_ENST00000336199_SDCCAG8_chr1_243468015_ENST00000343783_length(amino acids)=502AA_BP=14
MWIYLIPSTTFQWQEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVH
MQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKD
MMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAK
TNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKI
QQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ

--------------------------------------------------------------
>3507_3507_2_AKT3-SDCCAG8_AKT3_chr1_243858893_ENST00000336199_SDCCAG8_chr1_243468015_ENST00000355875_length(transcript)=2006nt_BP=238nt
CCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAA
GAAGGTTGGGTTCAGAAGAGGGGAGAATATATAAAAAACTGGAGGCCAAGATACTTCCTTTTGAAGACAGATGGCTCATTCATAGGATAT
AAAGAGAAACCTCAAGATGTGGATTTACCTTATCCCCTCAACAACTTTTCAGTGGCAAGAGAAGCTAAAACTTACTTATGAGGAAAAGTG
TGAAATTGAGGAATCCCAATTGAAGTTTTTGAGGAACGACTTAGCTGAATATCAGAGAACTTGTGAAGATCTTAAAGAGCAACTAAAGCA
TAAAGAATTTCTTCTGGCTGCTAATACTTGTAACCGTGTTGGTGGTCTTTGTTTGAAATGTGCTCAGCATGAAGCTGTTCTTTCCCAAAC
CCATACTAATGTTCATATGCAGACCATCGAAAGACTGGTTAAAGAAAGAGATGACTTGATGTCTGCACTAGTTTCCGTAAGGAGCAGCTT
GGCAGATACGCAGCAAAGAGAAGCAAGTGCTTATGAACAGGTGAAACAAGTTTTGCAAATATCTGAGGAAGCCAATTTTGAAAAAACCAA
GGCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAG
GGCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGC
CCAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCG
GGAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAG
AGAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACA
CTTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCA
CCTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGA
GCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTT
GACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCA
AGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACA
TGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCA
GCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGG
ATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCC
AGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGA
CTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACA

>3507_3507_2_AKT3-SDCCAG8_AKT3_chr1_243858893_ENST00000336199_SDCCAG8_chr1_243468015_ENST00000355875_length(amino acids)=502AA_BP=14
MWIYLIPSTTFQWQEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVH
MQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKD
MMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAK
TNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKI
QQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ

--------------------------------------------------------------
>3507_3507_3_AKT3-SDCCAG8_AKT3_chr1_243858893_ENST00000336199_SDCCAG8_chr1_243468015_ENST00000366541_length(transcript)=2012nt_BP=238nt
CCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAA
GAAGGTTGGGTTCAGAAGAGGGGAGAATATATAAAAAACTGGAGGCCAAGATACTTCCTTTTGAAGACAGATGGCTCATTCATAGGATAT
AAAGAGAAACCTCAAGATGTGGATTTACCTTATCCCCTCAACAACTTTTCAGTGGCAAGAGAAGCTAAAACTTACTTATGAGGAAAAGTG
TGAAATTGAGGAATCCCAATTGAAGTTTTTGAGGAACGACTTAGCTGAATATCAGAGAACTTGTGAAGATCTTAAAGAGCAACTAAAGCA
TAAAGAATTTCTTCTGGCTGCTAATACTTGTAACCGTGTTGGTGGTCTTTGTTTGAAATGTGCTCAGCATGAAGCTGTTCTTTCCCAAAC
CCATACTAATGTTCATATGCAGACCATCGAAAGACTGGTTAAAGAAAGAGATGACTTGATGTCTGCACTAGTTTCCGTAAGGAGCAGCTT
GGCAGATACGCAGCAAAGAGAAGCAAGTGCTTATGAACAGGTGAAACAAGTTTTGCAAATATCTGAGGAAGCCAATTTTGAAAAAACCAA
GGCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAG
GGCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGC
CCAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCG
GGAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAG
AGAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACA
CTTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCA
CCTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGA
GCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTT
GACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCA
AGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACA
TGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCA
GCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGG
ATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCC
AGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGA
CTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACA

>3507_3507_3_AKT3-SDCCAG8_AKT3_chr1_243858893_ENST00000336199_SDCCAG8_chr1_243468015_ENST00000366541_length(amino acids)=502AA_BP=14
MWIYLIPSTTFQWQEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVH
MQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKD
MMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAK
TNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKI
QQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ

--------------------------------------------------------------
>3507_3507_4_AKT3-SDCCAG8_AKT3_chr1_243858893_ENST00000336199_SDCCAG8_chr1_243468015_ENST00000391846_length(transcript)=646nt_BP=238nt
CCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAA
GAAGGTTGGGTTCAGAAGAGGGGAGAATATATAAAAAACTGGAGGCCAAGATACTTCCTTTTGAAGACAGATGGCTCATTCATAGGATAT
AAAGAGAAACCTCAAGATGTGGATTTACCTTATCCCCTCAACAACTTTTCAGTGGCAAGAGAAGCTAAAACTTACTTATGAGGAAAAGTG
TGAAATTGAGGAATCCCAATTGAAGTTTTTGAGGAACGACTTAGCTGAATATCAGAGAACTTGTGAAGATCTTAAAGAGCAACTAAAGCA
TAAAGAATTTCTTCTGGCTGCTAATACTTGTAACCGTGTTGGTGGTCTTTGTTTGAAATGTGCTCAGCATGAAGCTGTTCTTTCCCAAAC
CCATACTAATGTTCATATGCAGACCATCGAAAGACTGGTTAAAGAAAGAGATGACTTGATGTCTGCACTAGTTTCCGTAAGGAGCAGCTT
GGCAGATACGCAGCAAAGAGAAGCAAGTGCTTATGAACAGGTGAAACAAGTTTTGCAAATATCTGAGGAAGCCAATTTTGAAAAAACCAA

>3507_3507_4_AKT3-SDCCAG8_AKT3_chr1_243858893_ENST00000336199_SDCCAG8_chr1_243468015_ENST00000391846_length(amino acids)=150AA_BP=14
MWIYLIPSTTFQWQEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVH

--------------------------------------------------------------
>3507_3507_5_AKT3-SDCCAG8_AKT3_chr1_243858893_ENST00000366539_SDCCAG8_chr1_243468015_ENST00000343783_length(transcript)=2145nt_BP=373nt
CCCTCTCCTCCCCCCGCCCCCCCCCGGCTCCATCCTCCGCCGCCGCCCGAGCAGCTGCGGGGCCGCCACCGCCGCCGCCGCCGTTGCAGG
CTGAGTCATCACTAGAGAGTGGGAAGGGCAGCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTG
GGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGAGAATATATAAAAAACTGGAGG
CCAAGATACTTCCTTTTGAAGACAGATGGCTCATTCATAGGATATAAAGAGAAACCTCAAGATGTGGATTTACCTTATCCCCTCAACAAC
TTTTCAGTGGCAAGAGAAGCTAAAACTTACTTATGAGGAAAAGTGTGAAATTGAGGAATCCCAATTGAAGTTTTTGAGGAACGACTTAGC
TGAATATCAGAGAACTTGTGAAGATCTTAAAGAGCAACTAAAGCATAAAGAATTTCTTCTGGCTGCTAATACTTGTAACCGTGTTGGTGG
TCTTTGTTTGAAATGTGCTCAGCATGAAGCTGTTCTTTCCCAAACCCATACTAATGTTCATATGCAGACCATCGAAAGACTGGTTAAAGA
AAGAGATGACTTGATGTCTGCACTAGTTTCCGTAAGGAGCAGCTTGGCAGATACGCAGCAAAGAGAAGCAAGTGCTTATGAACAGGTGAA
ACAAGTTTTGCAAATATCTGAGGAAGCCAATTTTGAAAAAACCAAGGCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCA
GGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAG
GGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTC
AGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCT
GAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCA
GGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTG
CCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAA
GGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAAC
TGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGA
ACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAG
AAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCA
GGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCT
GCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATT
CATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAAC
GCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTT

>3507_3507_5_AKT3-SDCCAG8_AKT3_chr1_243858893_ENST00000366539_SDCCAG8_chr1_243468015_ENST00000343783_length(amino acids)=502AA_BP=14
MWIYLIPSTTFQWQEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVH
MQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKD
MMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAK
TNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKI
QQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ

--------------------------------------------------------------
>3507_3507_6_AKT3-SDCCAG8_AKT3_chr1_243858893_ENST00000366539_SDCCAG8_chr1_243468015_ENST00000355875_length(transcript)=2141nt_BP=373nt
CCCTCTCCTCCCCCCGCCCCCCCCCGGCTCCATCCTCCGCCGCCGCCCGAGCAGCTGCGGGGCCGCCACCGCCGCCGCCGCCGTTGCAGG
CTGAGTCATCACTAGAGAGTGGGAAGGGCAGCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTG
GGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGAGAATATATAAAAAACTGGAGG
CCAAGATACTTCCTTTTGAAGACAGATGGCTCATTCATAGGATATAAAGAGAAACCTCAAGATGTGGATTTACCTTATCCCCTCAACAAC
TTTTCAGTGGCAAGAGAAGCTAAAACTTACTTATGAGGAAAAGTGTGAAATTGAGGAATCCCAATTGAAGTTTTTGAGGAACGACTTAGC
TGAATATCAGAGAACTTGTGAAGATCTTAAAGAGCAACTAAAGCATAAAGAATTTCTTCTGGCTGCTAATACTTGTAACCGTGTTGGTGG
TCTTTGTTTGAAATGTGCTCAGCATGAAGCTGTTCTTTCCCAAACCCATACTAATGTTCATATGCAGACCATCGAAAGACTGGTTAAAGA
AAGAGATGACTTGATGTCTGCACTAGTTTCCGTAAGGAGCAGCTTGGCAGATACGCAGCAAAGAGAAGCAAGTGCTTATGAACAGGTGAA
ACAAGTTTTGCAAATATCTGAGGAAGCCAATTTTGAAAAAACCAAGGCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCA
GGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAG
GGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTC
AGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCT
GAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCA
GGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTG
CCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAA
GGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAAC
TGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGA
ACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAG
AAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCA
GGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCT
GCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATT
CATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAAC
GCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTT

>3507_3507_6_AKT3-SDCCAG8_AKT3_chr1_243858893_ENST00000366539_SDCCAG8_chr1_243468015_ENST00000355875_length(amino acids)=502AA_BP=14
MWIYLIPSTTFQWQEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVH
MQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKD
MMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAK
TNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKI
QQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ

--------------------------------------------------------------
>3507_3507_7_AKT3-SDCCAG8_AKT3_chr1_243858893_ENST00000366539_SDCCAG8_chr1_243468015_ENST00000366541_length(transcript)=2147nt_BP=373nt
CCCTCTCCTCCCCCCGCCCCCCCCCGGCTCCATCCTCCGCCGCCGCCCGAGCAGCTGCGGGGCCGCCACCGCCGCCGCCGCCGTTGCAGG
CTGAGTCATCACTAGAGAGTGGGAAGGGCAGCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTG
GGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGAGAATATATAAAAAACTGGAGG
CCAAGATACTTCCTTTTGAAGACAGATGGCTCATTCATAGGATATAAAGAGAAACCTCAAGATGTGGATTTACCTTATCCCCTCAACAAC
TTTTCAGTGGCAAGAGAAGCTAAAACTTACTTATGAGGAAAAGTGTGAAATTGAGGAATCCCAATTGAAGTTTTTGAGGAACGACTTAGC
TGAATATCAGAGAACTTGTGAAGATCTTAAAGAGCAACTAAAGCATAAAGAATTTCTTCTGGCTGCTAATACTTGTAACCGTGTTGGTGG
TCTTTGTTTGAAATGTGCTCAGCATGAAGCTGTTCTTTCCCAAACCCATACTAATGTTCATATGCAGACCATCGAAAGACTGGTTAAAGA
AAGAGATGACTTGATGTCTGCACTAGTTTCCGTAAGGAGCAGCTTGGCAGATACGCAGCAAAGAGAAGCAAGTGCTTATGAACAGGTGAA
ACAAGTTTTGCAAATATCTGAGGAAGCCAATTTTGAAAAAACCAAGGCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCA
GGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAG
GGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTC
AGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCT
GAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCA
GGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTG
CCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAA
GGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAAC
TGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGA
ACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAG
AAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCA
GGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCT
GCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATT
CATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAAC
GCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTT

>3507_3507_7_AKT3-SDCCAG8_AKT3_chr1_243858893_ENST00000366539_SDCCAG8_chr1_243468015_ENST00000366541_length(amino acids)=502AA_BP=14
MWIYLIPSTTFQWQEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVH
MQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKD
MMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAK
TNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKI
QQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ

--------------------------------------------------------------
>3507_3507_8_AKT3-SDCCAG8_AKT3_chr1_243858893_ENST00000366539_SDCCAG8_chr1_243468015_ENST00000391846_length(transcript)=781nt_BP=373nt
CCCTCTCCTCCCCCCGCCCCCCCCCGGCTCCATCCTCCGCCGCCGCCCGAGCAGCTGCGGGGCCGCCACCGCCGCCGCCGCCGTTGCAGG
CTGAGTCATCACTAGAGAGTGGGAAGGGCAGCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTG
GGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGAGAATATATAAAAAACTGGAGG
CCAAGATACTTCCTTTTGAAGACAGATGGCTCATTCATAGGATATAAAGAGAAACCTCAAGATGTGGATTTACCTTATCCCCTCAACAAC
TTTTCAGTGGCAAGAGAAGCTAAAACTTACTTATGAGGAAAAGTGTGAAATTGAGGAATCCCAATTGAAGTTTTTGAGGAACGACTTAGC
TGAATATCAGAGAACTTGTGAAGATCTTAAAGAGCAACTAAAGCATAAAGAATTTCTTCTGGCTGCTAATACTTGTAACCGTGTTGGTGG
TCTTTGTTTGAAATGTGCTCAGCATGAAGCTGTTCTTTCCCAAACCCATACTAATGTTCATATGCAGACCATCGAAAGACTGGTTAAAGA
AAGAGATGACTTGATGTCTGCACTAGTTTCCGTAAGGAGCAGCTTGGCAGATACGCAGCAAAGAGAAGCAAGTGCTTATGAACAGGTGAA

>3507_3507_8_AKT3-SDCCAG8_AKT3_chr1_243858893_ENST00000366539_SDCCAG8_chr1_243468015_ENST00000391846_length(amino acids)=150AA_BP=14
MWIYLIPSTTFQWQEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVH

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Fusion Gene PPI Analysis for AKT3-SDCCAG8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AKT3-SDCCAG8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AKT3-SDCCAG8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAKT3C4014738MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 24GENOMICS_ENGLAND;UNIPROT
HgeneAKT3C4012727MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 12GENOMICS_ENGLAND
HgeneAKT3C0152427Polydactyly1GENOMICS_ENGLAND
HgeneAKT3C0431380Cortical Dysplasia1CTD_human
HgeneAKT3C0431391Hemimegalencephaly1ORPHANET
HgeneAKT3C1863924Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome1CTD_human;ORPHANET
HgeneAKT3C1955869Malformations of Cortical Development1CTD_human
TgeneC3150877SENIOR-LOKEN SYNDROME 73GENOMICS_ENGLAND
TgeneC3889474BARDET-BIEDL SYNDROME 163CTD_human;GENOMICS_ENGLAND
TgeneC0403553Renal dysplasia and retinal aplasia (disorder)2GENOMICS_ENGLAND;ORPHANET
TgeneC0752166Bardet-Biedl Syndrome2GENOMICS_ENGLAND;ORPHANET
TgeneC0022679Cystic kidney1CTD_human
TgeneC0035309Retinal Diseases1CTD_human
TgeneC0036341Schizophrenia1PSYGENET
TgeneC1691228Cystic Kidney Diseases1CTD_human
TgeneC3714756Intellectual Disability1GENOMICS_ENGLAND