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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AKT3-CEP170 (FusionGDB2 ID:HG10000TG9859)

Fusion Gene Summary for AKT3-CEP170

check button Fusion gene summary
Fusion gene informationFusion gene name: AKT3-CEP170
Fusion gene ID: hg10000tg9859
HgeneTgene
Gene symbol

AKT3

CEP170

Gene ID

10000

9859

Gene nameAKT serine/threonine kinase 3centrosomal protein 170
SynonymsMPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2FAM68A|KAB|KIAA0470
Cytomap('AKT3')('CEP170')

1q43-q44

1q43

Type of geneprotein-codingprotein-coding
DescriptionRAC-gamma serine/threonine-protein kinasePKB gammaRAC-gamma serine/threonine protein kinasev-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)centrosomal protein of 170 kDaKARP-1-binding proteinXRCC5 binding proteincentrosomal protein 170kDa
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263826, ENST00000336199, 
ENST00000366539, ENST00000366540, 
ENST00000492957, 		ENST00000492957, 
ENST00000263826, ENST00000336199, 
ENST00000366539, ENST00000366540, 
Fusion gene scores* DoF score18 X 15 X 7=18905 X 4 X 4=80
# samples 215
** MAII scorelog2(21/1890*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKT3 [Title/Abstract] AND CEP170 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKT3(244006427)-CEP170(243336148), # samples:1
Anticipated loss of major functional domain due to fusion event.AKT3-CEP170 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-CEP170 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-CEP170 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-CEP170 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CEP170-AKT3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CEP170-AKT3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-CEP170 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
AKT3-CEP170 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
AKT3-CEP170 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
AKT3-CEP170 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKT3

GO:0043536

positive regulation of blood vessel endothelial cell migration

28254819

HgeneAKT3

GO:1905564

positive regulation of vascular endothelial cell proliferation

28254819


check buttonFusion gene breakpoints across AKT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CEP170 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0211-01AAKT3chr1

244006427

-CEP170chr1

243336148

-


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Fusion Gene ORF analysis for AKT3-CEP170

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263826ENST00000468254AKT3chr1

244006427

-CEP170chr1

243336148

-
5CDS-intronENST00000263826ENST00000481987AKT3chr1

244006427

-CEP170chr1

243336148

-
5CDS-intronENST00000263826ENST00000490813AKT3chr1

244006427

-CEP170chr1

243336148

-
5CDS-intronENST00000336199ENST00000468254AKT3chr1

244006427

-CEP170chr1

243336148

-
5CDS-intronENST00000336199ENST00000481987AKT3chr1

244006427

-CEP170chr1

243336148

-
5CDS-intronENST00000336199ENST00000490813AKT3chr1

244006427

-CEP170chr1

243336148

-
5CDS-intronENST00000366539ENST00000468254AKT3chr1

244006427

-CEP170chr1

243336148

-
5CDS-intronENST00000366539ENST00000481987AKT3chr1

244006427

-CEP170chr1

243336148

-
5CDS-intronENST00000366539ENST00000490813AKT3chr1

244006427

-CEP170chr1

243336148

-
5CDS-intronENST00000366540ENST00000468254AKT3chr1

244006427

-CEP170chr1

243336148

-
5CDS-intronENST00000366540ENST00000481987AKT3chr1

244006427

-CEP170chr1

243336148

-
5CDS-intronENST00000366540ENST00000490813AKT3chr1

244006427

-CEP170chr1

243336148

-
Frame-shiftENST00000366540ENST00000366542AKT3chr1

244006427

-CEP170chr1

243336148

-
Frame-shiftENST00000366540ENST00000366543AKT3chr1

244006427

-CEP170chr1

243336148

-
Frame-shiftENST00000366540ENST00000366544AKT3chr1

244006427

-CEP170chr1

243336148

-
In-frameENST00000263826ENST00000366542AKT3chr1

244006427

-CEP170chr1

243336148

-
In-frameENST00000263826ENST00000366543AKT3chr1

244006427

-CEP170chr1

243336148

-
In-frameENST00000263826ENST00000366544AKT3chr1

244006427

-CEP170chr1

243336148

-
In-frameENST00000336199ENST00000366542AKT3chr1

244006427

-CEP170chr1

243336148

-
In-frameENST00000336199ENST00000366543AKT3chr1

244006427

-CEP170chr1

243336148

-
In-frameENST00000336199ENST00000366544AKT3chr1

244006427

-CEP170chr1

243336148

-
In-frameENST00000366539ENST00000366542AKT3chr1

244006427

-CEP170chr1

243336148

-
In-frameENST00000366539ENST00000366543AKT3chr1

244006427

-CEP170chr1

243336148

-
In-frameENST00000366539ENST00000366544AKT3chr1

244006427

-CEP170chr1

243336148

-
intron-3CDSENST00000492957ENST00000366542AKT3chr1

244006427

-CEP170chr1

243336148

-
intron-3CDSENST00000492957ENST00000366543AKT3chr1

244006427

-CEP170chr1

243336148

-
intron-3CDSENST00000492957ENST00000366544AKT3chr1

244006427

-CEP170chr1

243336148

-
intron-intronENST00000492957ENST00000468254AKT3chr1

244006427

-CEP170chr1

243336148

-
intron-intronENST00000492957ENST00000481987AKT3chr1

244006427

-CEP170chr1

243336148

-
intron-intronENST00000492957ENST00000490813AKT3chr1

244006427

-CEP170chr1

243336148

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336199AKT3chr1244006427-ENST00000366542CEP170chr1243336148-532211221433001028
ENST00000336199AKT3chr1244006427-ENST00000366543CEP170chr1243336148-524411221432221002
ENST00000336199AKT3chr1244006427-ENST00000366544CEP170chr1243336148-532211221433001028
ENST00000366539AKT3chr1244006427-ENST00000366542CEP170chr1243336148-545724734934351028
ENST00000366539AKT3chr1244006427-ENST00000366543CEP170chr1243336148-537924734933571002
ENST00000366539AKT3chr1244006427-ENST00000366544CEP170chr1243336148-545724734934351028
ENST00000263826AKT3chr1244006427-ENST00000366542CEP170chr1243336148-533712722933151028
ENST00000263826AKT3chr1244006427-ENST00000366543CEP170chr1243336148-525912722932371002
ENST00000263826AKT3chr1244006427-ENST00000366544CEP170chr1243336148-533712722933151028

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336199ENST00000366542AKT3chr1244006427-CEP170chr1243336148-0.0002194020.9997806
ENST00000336199ENST00000366543AKT3chr1244006427-CEP170chr1243336148-0.00023790.9997621
ENST00000336199ENST00000366544AKT3chr1244006427-CEP170chr1243336148-0.0002194020.9997806
ENST00000366539ENST00000366542AKT3chr1244006427-CEP170chr1243336148-0.000299180.9997009
ENST00000366539ENST00000366543AKT3chr1244006427-CEP170chr1243336148-0.0003228060.9996772
ENST00000366539ENST00000366544AKT3chr1244006427-CEP170chr1243336148-0.000299180.9997009
ENST00000263826ENST00000366542AKT3chr1244006427-CEP170chr1243336148-0.0002339980.99976605
ENST00000263826ENST00000366543AKT3chr1244006427-CEP170chr1243336148-0.0002544180.99974555
ENST00000263826ENST00000366544AKT3chr1244006427-CEP170chr1243336148-0.0002339980.99976605

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Fusion Genomic Features for AKT3-CEP170


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AKT3-CEP170


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:244006427/chr1:243336148)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCEP170chr1:244006427chr1:243336148ENST000003665429201467_14955221585.0Coiled coilOntology_term=ECO:0000255
TgeneCEP170chr1:244006427chr1:243336148ENST000003665438191467_14954241461.0Coiled coilOntology_term=ECO:0000255
TgeneCEP170chr1:244006427chr1:243336148ENST000003665448191467_14954241487.0Coiled coilOntology_term=ECO:0000255
TgeneCEP170chr1:244006427chr1:243336148ENST000003665429201113_15845221585.0RegionNote=Targeting to centrosomes
TgeneCEP170chr1:244006427chr1:243336148ENST00000366542920853_15845221585.0RegionNote=Targeting to microtubules
TgeneCEP170chr1:244006427chr1:243336148ENST000003665438191113_15844241461.0RegionNote=Targeting to centrosomes
TgeneCEP170chr1:244006427chr1:243336148ENST00000366543819853_15844241461.0RegionNote=Targeting to microtubules
TgeneCEP170chr1:244006427chr1:243336148ENST000003665448191113_15844241487.0RegionNote=Targeting to centrosomes
TgeneCEP170chr1:244006427chr1:243336148ENST00000366544819853_15844241487.0RegionNote=Targeting to microtubules

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKT3chr1:244006427chr1:243336148ENST00000263826-113148_40515480.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:243336148ENST00000263826-113406_47915480.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:243336148ENST00000263826-1135_10715480.0DomainPH
HgeneAKT3chr1:244006427chr1:243336148ENST00000336199-114148_40515476.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:243336148ENST00000336199-114406_47915476.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:243336148ENST00000336199-1145_10715476.0DomainPH
HgeneAKT3chr1:244006427chr1:243336148ENST00000366539-214148_40515480.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:243336148ENST00000366539-214406_47915480.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:243336148ENST00000366539-2145_10715480.0DomainPH
HgeneAKT3chr1:244006427chr1:243336148ENST00000366540-214148_40515466.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:243336148ENST00000366540-214406_47915466.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:243336148ENST00000366540-2145_10715466.0DomainPH
HgeneAKT3chr1:244006427chr1:243336148ENST00000263826-113154_16215480.0Nucleotide bindingATP
HgeneAKT3chr1:244006427chr1:243336148ENST00000336199-114154_16215476.0Nucleotide bindingATP
HgeneAKT3chr1:244006427chr1:243336148ENST00000366539-214154_16215480.0Nucleotide bindingATP
HgeneAKT3chr1:244006427chr1:243336148ENST00000366540-214154_16215466.0Nucleotide bindingATP
TgeneCEP170chr1:244006427chr1:243336148ENST0000036654292023_735221585.0DomainFHA
TgeneCEP170chr1:244006427chr1:243336148ENST0000036654381923_734241461.0DomainFHA
TgeneCEP170chr1:244006427chr1:243336148ENST0000036654481923_734241487.0DomainFHA


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Fusion Gene Sequence for AKT3-CEP170


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3497_3497_1_AKT3-CEP170_AKT3_chr1_244006427_ENST00000263826_CEP170_chr1_243336148_ENST00000366542_length(transcript)=5337nt_BP=127nt
GCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGAT
GTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGTGTTTGGAGTAGATGACAATCAGGATTATAATAGGCCTGTTATCAACGAAAA
ACATAAAGATCTAATAAAAGATTGGGCTCTCAGTTCTGCTGCAGCAGTAATGGAAGAAAGAAAACCACTGACTACATCTGGATTTCACCA
CTCAGAGGAAGGCACATCTTCATCTGGAAGCAAACGTTGGGTTTCACAGTGGGCTAGTTTGGCTGCCAATCATACAAGGCATGATCAAGA
AGAAAGGATAATGGAATTTTCTGCACCTCTTCCTTTAGAGAATGAGACAGAGATCAGTGAGTCTGGCATGACAGTGAGAAGTACTGGCTC
TGCAACTTCCTTGGCTAGCCAGGGAGAGAGAAGGAGACGAACTCTTCCCCAGCTTCCAAATGAAGAAAAGTCTCTTGAGAGCCACAGAGC
AAAGGTTGTAACACAGAGGTCAGAGATAGGAGAAAAACAAGACACAGAACTTCAGGAGAAAGAAACACCTACACAGGTATACCAGAAAGA
TAAACAAGATGCTGACAGACCCTTGAGTAAAATGAACAGGGCAGTAAATGGAGAGACTCTCAAAACTGGTGGAGATAATAAAACCCTACT
TCACTTAGGCAGCTCTGCTCCTGGAAAAGAGAAAAGTGAAACTGATAAGGAAACTTCTTTGGTAAAGCAAACATTAGCAAAACTTCAACA
ACAAGAACAAAGGGAGGAGGCTCAGTGGACACCTACTAAATTGTCTTCCAAAAATGTTTCAGGTCAGACAGATAAATGTAGGGAGGAAAC
TTTTAAACAAGAATCACAACCTCCAGAAAAAAATTCAGGACATTCTACAAGCAAAGGAGACAGAGTGGCACAAAGTGAGAGCAAGAGAAG
AAAAGCTGAGGAAATTCTGAAAAGTCAGACTCCAAAGGGAGGAGACAAGAAGGAATCCTCCAAGTCATTAGTGCGACAAGGGAGCTTCAC
TATAGAAAAACCCAGCCCAAACATACCCATAGAACTTATTCCCCATATAAATAAACAGACTTCCTCTACTCCTTCTTCTTTAGCATTAAC
ATCTGCAAGTAGAATACGAGAAAGAAGTGAGTCTTTGGATCCTGATTCTAGTATGGACACAACCCTTATTCTAAAAGACACAGAAGCAGT
AATGGCTTTTCTAGAAGCTAAACTACGTGAAGATAATAAAACTGATGAAGGACCAGATACTCCCAGTTATAATAGAGACAATTCTATTTC
ACCAGAATCTGATGTAGATACAGCTAGTACAATCAGTCTGGTTACTGGAGAAACTGAAAGAAAGTCAACCCAAAAGCGAAAGAGTTTCAC
TAGCCTCTATAAAGATAGGTGTTCCACAGGTTCTCCTTCCAAAGATGTTACAAAATCATCATCTTCAGGTGCTAGGGAAAAAATGGAAAA
GAAAACAAAAAGTCGTTCCACAGATGTGGGTTCAAGAGCAGATGGTCGTAAATTTGTTCAGTCCAGTGGGAGAATAAGACAGCCCTCAGT
AGACTTAACAGATGATGACCAAACCTCTAGTGTACCTCATTCTGCCATCTCTGATATTATGTCATCTGATCAAGAAACTTACTCTTGTAA
ACCTCATGGACGGACTCCACTTACCTCAGCTGATGAGCATGTACATTCCAAACTGGAAGGAAGTAAAGTAACGAAATCTAAGACTTCTCC
GGTGGTATCTGGTTCATCTAGTAAATCAACCACCCTTCCAAGGCCACGACCTACCAGGACTTCCCTCTTGCGCAGAGCACGACTTGGTGA
AGCTTCAGACAGTGAACTTGCTGATGCTGACAAAGCATCTGTTGCTTCTGAAGTATCCACAACAAGTTCTACATCAAAACCTCCCACAGG
AAGGCGTAACATCTCTCGGATTGATTTATTGGCTCAGCCTCGTAGAACACGACTTGGCTCACTGTCAGCTCGTAGTGACTCTGAAGCAAC
AATTTCTAGAAGTAGTGCCTCTTCGAGGACCGCAGAAGCCATCATTAGAAGTGGAGCCAGACTAGTACCATCAGATAAATTTTCTCCTAG
AATTAGAGCTAACAGTATCTCTCGACTCTCAGACTCCAAGGTCAAAAGTATGACCTCAGCTCATGGCTCTGCTTCAGTAAATTCAAGATG
GAGGCGCTTTCCTACTGATTATGCTTCCACCTCAGAAGATGAATTTGGATCAAACCGTAATTCCCCTAAACATACCCGTCTACGTACTTC
TCCAGCCCTGAAAACCACTCGCTTGCAGAGCGCTGGATCAGCAATGCCTACTAGTTCTTCATTCAAACACCGGATTAAAGAGCAGGAAGA
CTACATCCGAGATTGGACTGCTCATCGAGAAGAGATAGCCAGGATCAGCCAAGATCTTGCTCTCATTGCTCGGGAGATCAACGATGTAGC
AGGAGAGATAGATTCAGTGACTTCATCAGGCACTGCCCCTAGTACCACAGTAAGCACTGCTGCCACCACCCCTGGCTCTGCCATAGACAC
TAGAGAAGAGTTGGTTGATCGTGTTTTTGATGAAAGCCTCAACTTCCGAAAGATTCCTCCATTAGTTCATTCCAAAACACCAGAAGGAAA
CAACGGTCGATCTGGTGATCCAAGACCTCAAGCAGCAGAGCCTCCCGATCACTTAACAATTACAAGGCGGAGAACCTGGAGCAGGGATGA
AGTCATGGGAGATAATCTGCTGCTGTCATCCGTCTTTCAGTTCTCTAAGAAGATAAGACAATCTATAGATAAGACAGCTGGAAAGATCAG
AATATTATTTAAAGACAAAGATCGGAATTGGGATGACATAGAAAGCAAATTAAGAGCCGAAAGTGAAGTCCCTATTGTGAAAACCTCAAG
CATGGAGATTTCTTCTATCTTACAGGAACTGAAAAGAGTAGAAAAGCAGCTGCAAGCAATCAATGCTATGATTGATCCTGATGGAACTTT
GGAGGCTCTGAACAACATGGGATTTCCCAGTGCTATGTTGCCATCTCCACCGAAACAGAAGTCCAGCCCTGTGAATAACCACCACAGCCC
GGGTCAGACACCAACACTTGGCCAACCAGAAGCTAGGGCTCTTCATCCTGCTGCTGTTTCAGCCGCAGCTGAATTTGAGAATGCTGAATC
TGAGGCTGATTTCAGTATACATTTCAATAGATTCAACCCCGATGGGGAAGAGGAAGATGTTACAGTACAAGAATGACTTTCTCTTGATTG
TTGAAAAATCATTACCTGTGGAATGGCTAGGAATATTGGAAGCAGCATAGTGTTGATGTACGCAAAACAAGACAGCTTGGTCAGCTACAA
TCTTGGAATCCCTGTCTTCTTAATTTTATTTATTTATTTTTGACGTATAATGTAGTATATCAATCCTTTCAAACTATTTAGATAACCACT
TGATGCACAAATAGGAAAAAGCAGATTGTGGCAGTGTCGCCTTTTGTGGTTTTATGATTTTCAAATTGAATTTAATGATTACACCCTTTC
CCTTCATAGATCTTTTTTCTTTTTTTTAAGCCATGCTGTGACCTACAAGCAAACTAAATAGCCAACATTTCTGAACCCCTAAGTCTCCTG
TGCCAAGCTGCTCCCTGAAATGGACTTCTTCATCTGTACAGATTTGTTAAACCATTCTATTTGCTTCTTAATAATAGGATTTATATTAGT
ACTCATTACCATTGGACACAATGACATAAGTACTCTCCACAGTAAAGCAGACCTTTCACAACAGTCACTCTGTGTCCTAAAATTTTCCAA
CATAGATGTGATTTATATAACTTTGTTGATACGTAAATTGTCTTGGGGTTTACGGAAATTAACTATTATGTTTGCACTAAGATTTGCTGG
GAGTGGTAGGTGGACATATCTATATATCAATAAGGACTAACCGTCTTTTTTGTACATAGGAGATTGATAATACTGTATTTGTTTTAAGCC
CACAGTGTTTTACTCCACTTTCAAAAAGATCAATTTGGCACTTTTTTTCATTTTTTTTAATGGAAATAAGATTTGGTCTCTCATTTTAGG
TTAAATGATAACTAGAAAGATTAAACTAGACAGATAGTTTAGGTGGAGTATATTTTTAAAACTCAGAACATGTATATTGGTCCTGTGTTA
CCAAGTTTATATGTGACAGTTGAAAAAGAAATTCCCTTGAAATGATCATGAGGTTAAAATTTTCTTCATTAGGGGACTTGGAGAACCAGT
AGTCGTAAGATTAGTTGATAGTTTCACTCCCAAGCAATGAATTGCTTCTGTGTGTTTCCCTGTAGGACTCAATAGTAAATGCTGTCTGTC
TTACACATTTATAAGGACCCTGCAAGACGACGACAAAGGCCTTTGGCCTGTGCTACTAAACAAGAAGCCTATGAAAAATTTCTTCTTTAA
ACTTGTTTTTTCTCTTTCCAGTAAGTTCACATTTGGATAATTTTAAAAAGAAAAGTAATTACCTTTGTGTTTCCAGAACACTATAATTGG
GGTGTATCTTAATTCAGTTAAATATTATTAGTAGACCTGGATTTTCCCCCTTGACCCCATCAGTCTATAAAGGTTAAACTGCAACTTTTA
TGAAATGGTCTTTAATATTTCCACAATAATCCTGTGCTATATTTGTTTTAAGAAACAAAGTAACTCTATACACTTCAAGACTTTACAGGA
TTTTTTAAATCCTGTATTGTTGGATCAATTAATAAAGATGCAAAAAAACTTTATAGAGATGTAAAAACAAAACTATAATGGATCTCCTAT
TTTTCTTTAAATACAAAAAAAAAAAGGTAAATGAACTATTCTCCTTGTAAAGCTAAATTCCCCATTCTGTCTAATAAAGGAAGACTGAAA
AAAGGTTTTAAAGAACATAAATGGAAAGATACAAATGCTTTGAAGGAATAAACGAAATGTTAAAACAGGGTCAATCCATTTGAAGAAAAA
GTTGGACAAAATAATCAGCATTGCTCCCTCTTTTATTTAATATTTGGGTACTGATTATATCCACATGGAAGTAGAAGGTAAGGAGTTTAG
GAAAATACTAGAATCTACTCTGCTTACATTCTTGTTTAAGTGTTTACACAGTTTGGTTCAATTATAAACATTTGGCCTTTTACTATGTTA
TTTTTATTTTGTATGAATACATTATCCTCCTTATTTATTTTTGTTACATTTATTACTTATGTTATTTTGTTATGCATTTACAACTCCATT

>3497_3497_1_AKT3-CEP170_AKT3_chr1_244006427_ENST00000263826_CEP170_chr1_243336148_ENST00000366542_length(amino acids)=1028AA_BP=
MEERKPLTTSGFHHSEEGTSSSGSKRWVSQWASLAANHTRHDQEERIMEFSAPLPLENETEISESGMTVRSTGSATSLASQGERRRRTLP
QLPNEEKSLESHRAKVVTQRSEIGEKQDTELQEKETPTQVYQKDKQDADRPLSKMNRAVNGETLKTGGDNKTLLHLGSSAPGKEKSETDK
ETSLVKQTLAKLQQQEQREEAQWTPTKLSSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDRVAQSESKRRKAEEILKSQTPKGGDK
KESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSSLALTSASRIRERSESLDPDSSMDTTLILKDTEAVMAFLEAKLREDNKTDE
GPDTPSYNRDNSISPESDVDTASTISLVTGETERKSTQKRKSFTSLYKDRCSTGSPSKDVTKSSSSGAREKMEKKTKSRSTDVGSRADGR
KFVQSSGRIRQPSVDLTDDDQTSSVPHSAISDIMSSDQETYSCKPHGRTPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPR
PTRTSLLRRARLGEASDSELADADKASVASEVSTTSSTSKPPTGRRNISRIDLLAQPRRTRLGSLSARSDSEATISRSSASSRTAEAIIR
SGARLVPSDKFSPRIRANSISRLSDSKVKSMTSAHGSASVNSRWRRFPTDYASTSEDEFGSNRNSPKHTRLRTSPALKTTRLQSAGSAMP
TSSSFKHRIKEQEDYIRDWTAHREEIARISQDLALIAREINDVAGEIDSVTSSGTAPSTTVSTAATTPGSAIDTREELVDRVFDESLNFR
KIPPLVHSKTPEGNNGRSGDPRPQAAEPPDHLTITRRRTWSRDEVMGDNLLLSSVFQFSKKIRQSIDKTAGKIRILFKDKDRNWDDIESK
LRAESEVPIVKTSSMEISSILQELKRVEKQLQAINAMIDPDGTLEALNNMGFPSAMLPSPPKQKSSPVNNHHSPGQTPTLGQPEARALHP

--------------------------------------------------------------
>3497_3497_2_AKT3-CEP170_AKT3_chr1_244006427_ENST00000263826_CEP170_chr1_243336148_ENST00000366543_length(transcript)=5259nt_BP=127nt
GCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGAT
GTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGTGTTTGGAGTAGATGACAATCAGGATTATAATAGGCCTGTTATCAACGAAAA
ACATAAAGATCTAATAAAAGATTGGGCTCTCAGTTCTGCTGCAGCAGTAATGGAAGAAAGAAAACCACTGACTACATCTGGATTTCACCA
CTCAGAGGAAGGCACATCTTCATCTGGAAGCAAACGTTGGGTTTCACAGTGGGCTAGTTTGGCTGCCAATCATACAAGGCATGATCAAGA
AGAAAGGATAATGGAATTTTCTGCACCTCTTCCTTTAGAGAATGAGACAGAGATCAGTGAGTCTGGCATGACAGTGAGAAGTACTGGCTC
TGCAACTTCCTTGGCTAGCCAGGGAGAGAGAAGGAGACGAACTCTTCCCCAGCTTCCAAATGAAGAAAAGTCTCTTGAGAGCCACAGAGC
AAAGGTTGTAACACAGAGGTCAGAGATAGGAGAAAAACAAGACACAGAACTTCAGGAGAAAGAAACACCTACACAGGTATACCAGAAAGA
TAAACAAGATGCTGACAGACCCTTGAGTAAAATGAACAGGGCAGTAAATGGAGAGACTCTCAAAACTGGTGGAGATAATAAAACCCTACT
TCACTTAGGCAGCTCTGCTCCTGGAAAAGAGAAAAGTGAAACTGATAAGGAAACTTCTTTGGTAAAGCAAACATTAGCAAAACTTCAACA
ACAAGAACAAAGGGAGGAGGCTCAGTGGACACCTACTAAATTGTCTTCCAAAAATGTTTCAGGTCAGACAGATAAATGTAGGGAGGAAAC
TTTTAAACAAGAATCACAACCTCCAGAAAAAAATTCAGGACATTCTACAAGCAAAGGAGACAGAGTGGCACAAAGTGAGAGCAAGAGAAG
AAAAGCTGAGGAAATTCTGAAAAGTCAGACTCCAAAGGGAGGAGACAAGAAGGAATCCTCCAAGTCATTAGTGCGACAAGGGAGCTTCAC
TATAGAAAAACCCAGCCCAAACATACCCATAGAACTTATTCCCCATATAAATAAACAGACTTCCTCTACTCCTTCTTCTTTAGCATTAAC
ATCTGCAAGTAGAATACGAGAAAGAAGTGAGTCTTTGGATCCTGATTCTAGTATGGACACAACCCTTATTCTAAAAGACACAGAAGCAGT
AATGGCTTTTCTAGAAGCTAAACTACGTGAAGATAATAAAACTGATGAAGGACCAGATACTCCCAGTTATAATAGAGACAATTCTATTTC
ACCAGAATCTGATGTAGATACAGCTAGTACAATCAGTCTGGTTACTGGAGAAACTGAAAGAAAGTCAACCCAAAAGCGAAAGAGTTTCAC
TAGCCTCTATAAAGATAGGTGTTCCACAGGTTCTCCTTCCAAAGATGTTACAAAATCATCATCTTCAGGTGCTAGGGAAAAAATGGAAAA
GAAAACAAAAAGTCGTTCCACAGATGTGGGTTCAAGAGCAGATGGTCGTAAATTTGTTCAGTCCAGTGGGAGAATAAGACAGCCCTCAGT
AGACTTAACAGATGATGACCAAACCTCTAGTGTACCTCATTCTGCCATCTCTGATATTATGTCATCTGATCAAGAAACTTACTCTTGTAA
ACCTCATGGACGGACTCCACTTACCTCAGCTGATGAGCATGTACATTCCAAACTGGAAGGAAGTAAAGTAACGAAATCTAAGACTTCTCC
GGTGGTATCTGGTTCATCTAGTAAATCAACCACCCTTCCAAGGCCACGACCTACCAGGACTTCCCTCTTGCGCAGAGCACGACTTGGTGA
AGCTTCAGACAGTGAACTTGCTGATGCTGACAAAGCATCTGTTGCTTCTGAAGTATCCACAACAAGTTCTACATCAAAACCTCCCACAGG
AAGGCGTAACATCTCTCGGATTGATTTATTGGCTCAGCCTCGTAGAACACGACTTGGCTCACTGTCAGCTCGTAGTGACTCTGAAGCAAC
AATTTCTAGAAGTAGTGCCTCTTCGAGGACCGCAGAAGCCATCATTAGAAGTGGAGCCAGACTAGTACCATCAGATAAATTTTCTCCTAG
AATTAGAGCTAACAGTATCTCTCGACTCTCAGACTCCAAGGTCAAAAGTATGACCTCAGCTCATGGCTCTGCTTCAGCCCTGAAAACCAC
TCGCTTGCAGAGCGCTGGATCAGCAATGCCTACTAGTTCTTCATTCAAACACCGGATTAAAGAGCAGGAAGACTACATCCGAGATTGGAC
TGCTCATCGAGAAGAGATAGCCAGGATCAGCCAAGATCTTGCTCTCATTGCTCGGGAGATCAACGATGTAGCAGGAGAGATAGATTCAGT
GACTTCATCAGGCACTGCCCCTAGTACCACAGTAAGCACTGCTGCCACCACCCCTGGCTCTGCCATAGACACTAGAGAAGAGGTAGGAGA
TCTTCATGGAGAAATGCATAAGTTGGTTGATCGTGTTTTTGATGAAAGCCTCAACTTCCGAAAGATTCCTCCATTAGTTCATTCCAAAAC
ACCAGAAGGAAACAACGGTCGATCTGGTGATCCAAGACCTCAAGCAGCAGAGCCTCCCGATCACTTAACAATTACAAGGCGGAGAACCTG
GAGCAGGGATGAAGTCATGGGAGATAATCTGCTGCTGTCATCCGTCTTTCAGTTCTCTAAGAAGATAAGACAATCTATAGATAAGACAGC
TGGAAAGATCAGAATATTATTTAAAGACAAAGATCGGAATTGGGATGACATAGAAAGCAAATTAAGAGCCGAAAGTGAAGTCCCTATTGT
GAAAACCTCAAGCATGGAGATTTCTTCTATCTTACAGGAACTGAAAAGAGTAGAAAAGCAGCTGCAAGCAATCAATGCTATGATTGATCC
TGATGGAACTTTGGAGGCTCTGAACAACATGGGATTTCCCAGTGCTATGTTGCCATCTCCACCGAAACAGAAGTCCAGCCCTGTGAATAA
CCACCACAGCCCGGGTCAGACACCAACACTTGGCCAACCAGAAGCTAGGGCTCTTCATCCTGCTGCTGTTTCAGCCGCAGCTGAATTTGA
GAATGCTGAATCTGAGGCTGATTTCAGTATACATTTCAATAGATTCAACCCCGATGGGGAAGAGGAAGATGTTACAGTACAAGAATGACT
TTCTCTTGATTGTTGAAAAATCATTACCTGTGGAATGGCTAGGAATATTGGAAGCAGCATAGTGTTGATGTACGCAAAACAAGACAGCTT
GGTCAGCTACAATCTTGGAATCCCTGTCTTCTTAATTTTATTTATTTATTTTTGACGTATAATGTAGTATATCAATCCTTTCAAACTATT
TAGATAACCACTTGATGCACAAATAGGAAAAAGCAGATTGTGGCAGTGTCGCCTTTTGTGGTTTTATGATTTTCAAATTGAATTTAATGA
TTACACCCTTTCCCTTCATAGATCTTTTTTCTTTTTTTTAAGCCATGCTGTGACCTACAAGCAAACTAAATAGCCAACATTTCTGAACCC
CTAAGTCTCCTGTGCCAAGCTGCTCCCTGAAATGGACTTCTTCATCTGTACAGATTTGTTAAACCATTCTATTTGCTTCTTAATAATAGG
ATTTATATTAGTACTCATTACCATTGGACACAATGACATAAGTACTCTCCACAGTAAAGCAGACCTTTCACAACAGTCACTCTGTGTCCT
AAAATTTTCCAACATAGATGTGATTTATATAACTTTGTTGATACGTAAATTGTCTTGGGGTTTACGGAAATTAACTATTATGTTTGCACT
AAGATTTGCTGGGAGTGGTAGGTGGACATATCTATATATCAATAAGGACTAACCGTCTTTTTTGTACATAGGAGATTGATAATACTGTAT
TTGTTTTAAGCCCACAGTGTTTTACTCCACTTTCAAAAAGATCAATTTGGCACTTTTTTTCATTTTTTTTAATGGAAATAAGATTTGGTC
TCTCATTTTAGGTTAAATGATAACTAGAAAGATTAAACTAGACAGATAGTTTAGGTGGAGTATATTTTTAAAACTCAGAACATGTATATT
GGTCCTGTGTTACCAAGTTTATATGTGACAGTTGAAAAAGAAATTCCCTTGAAATGATCATGAGGTTAAAATTTTCTTCATTAGGGGACT
TGGAGAACCAGTAGTCGTAAGATTAGTTGATAGTTTCACTCCCAAGCAATGAATTGCTTCTGTGTGTTTCCCTGTAGGACTCAATAGTAA
ATGCTGTCTGTCTTACACATTTATAAGGACCCTGCAAGACGACGACAAAGGCCTTTGGCCTGTGCTACTAAACAAGAAGCCTATGAAAAA
TTTCTTCTTTAAACTTGTTTTTTCTCTTTCCAGTAAGTTCACATTTGGATAATTTTAAAAAGAAAAGTAATTACCTTTGTGTTTCCAGAA
CACTATAATTGGGGTGTATCTTAATTCAGTTAAATATTATTAGTAGACCTGGATTTTCCCCCTTGACCCCATCAGTCTATAAAGGTTAAA
CTGCAACTTTTATGAAATGGTCTTTAATATTTCCACAATAATCCTGTGCTATATTTGTTTTAAGAAACAAAGTAACTCTATACACTTCAA
GACTTTACAGGATTTTTTAAATCCTGTATTGTTGGATCAATTAATAAAGATGCAAAAAAACTTTATAGAGATGTAAAAACAAAACTATAA
TGGATCTCCTATTTTTCTTTAAATACAAAAAAAAAAAGGTAAATGAACTATTCTCCTTGTAAAGCTAAATTCCCCATTCTGTCTAATAAA
GGAAGACTGAAAAAAGGTTTTAAAGAACATAAATGGAAAGATACAAATGCTTTGAAGGAATAAACGAAATGTTAAAACAGGGTCAATCCA
TTTGAAGAAAAAGTTGGACAAAATAATCAGCATTGCTCCCTCTTTTATTTAATATTTGGGTACTGATTATATCCACATGGAAGTAGAAGG
TAAGGAGTTTAGGAAAATACTAGAATCTACTCTGCTTACATTCTTGTTTAAGTGTTTACACAGTTTGGTTCAATTATAAACATTTGGCCT
TTTACTATGTTATTTTTATTTTGTATGAATACATTATCCTCCTTATTTATTTTTGTTACATTTATTACTTATGTTATTTTGTTATGCATT

>3497_3497_2_AKT3-CEP170_AKT3_chr1_244006427_ENST00000263826_CEP170_chr1_243336148_ENST00000366543_length(amino acids)=1002AA_BP=
MEERKPLTTSGFHHSEEGTSSSGSKRWVSQWASLAANHTRHDQEERIMEFSAPLPLENETEISESGMTVRSTGSATSLASQGERRRRTLP
QLPNEEKSLESHRAKVVTQRSEIGEKQDTELQEKETPTQVYQKDKQDADRPLSKMNRAVNGETLKTGGDNKTLLHLGSSAPGKEKSETDK
ETSLVKQTLAKLQQQEQREEAQWTPTKLSSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDRVAQSESKRRKAEEILKSQTPKGGDK
KESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSSLALTSASRIRERSESLDPDSSMDTTLILKDTEAVMAFLEAKLREDNKTDE
GPDTPSYNRDNSISPESDVDTASTISLVTGETERKSTQKRKSFTSLYKDRCSTGSPSKDVTKSSSSGAREKMEKKTKSRSTDVGSRADGR
KFVQSSGRIRQPSVDLTDDDQTSSVPHSAISDIMSSDQETYSCKPHGRTPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPR
PTRTSLLRRARLGEASDSELADADKASVASEVSTTSSTSKPPTGRRNISRIDLLAQPRRTRLGSLSARSDSEATISRSSASSRTAEAIIR
SGARLVPSDKFSPRIRANSISRLSDSKVKSMTSAHGSASALKTTRLQSAGSAMPTSSSFKHRIKEQEDYIRDWTAHREEIARISQDLALI
AREINDVAGEIDSVTSSGTAPSTTVSTAATTPGSAIDTREEVGDLHGEMHKLVDRVFDESLNFRKIPPLVHSKTPEGNNGRSGDPRPQAA
EPPDHLTITRRRTWSRDEVMGDNLLLSSVFQFSKKIRQSIDKTAGKIRILFKDKDRNWDDIESKLRAESEVPIVKTSSMEISSILQELKR
VEKQLQAINAMIDPDGTLEALNNMGFPSAMLPSPPKQKSSPVNNHHSPGQTPTLGQPEARALHPAAVSAAAEFENAESEADFSIHFNRFN

--------------------------------------------------------------
>3497_3497_3_AKT3-CEP170_AKT3_chr1_244006427_ENST00000263826_CEP170_chr1_243336148_ENST00000366544_length(transcript)=5337nt_BP=127nt
GCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGAT
GTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGTGTTTGGAGTAGATGACAATCAGGATTATAATAGGCCTGTTATCAACGAAAA
ACATAAAGATCTAATAAAAGATTGGGCTCTCAGTTCTGCTGCAGCAGTAATGGAAGAAAGAAAACCACTGACTACATCTGGATTTCACCA
CTCAGAGGAAGGCACATCTTCATCTGGAAGCAAACGTTGGGTTTCACAGTGGGCTAGTTTGGCTGCCAATCATACAAGGCATGATCAAGA
AGAAAGGATAATGGAATTTTCTGCACCTCTTCCTTTAGAGAATGAGACAGAGATCAGTGAGTCTGGCATGACAGTGAGAAGTACTGGCTC
TGCAACTTCCTTGGCTAGCCAGGGAGAGAGAAGGAGACGAACTCTTCCCCAGCTTCCAAATGAAGAAAAGTCTCTTGAGAGCCACAGAGC
AAAGGTTGTAACACAGAGGTCAGAGATAGGAGAAAAACAAGACACAGAACTTCAGGAGAAAGAAACACCTACACAGGTATACCAGAAAGA
TAAACAAGATGCTGACAGACCCTTGAGTAAAATGAACAGGGCAGTAAATGGAGAGACTCTCAAAACTGGTGGAGATAATAAAACCCTACT
TCACTTAGGCAGCTCTGCTCCTGGAAAAGAGAAAAGTGAAACTGATAAGGAAACTTCTTTGGTAAAGCAAACATTAGCAAAACTTCAACA
ACAAGAACAAAGGGAGGAGGCTCAGTGGACACCTACTAAATTGTCTTCCAAAAATGTTTCAGGTCAGACAGATAAATGTAGGGAGGAAAC
TTTTAAACAAGAATCACAACCTCCAGAAAAAAATTCAGGACATTCTACAAGCAAAGGAGACAGAGTGGCACAAAGTGAGAGCAAGAGAAG
AAAAGCTGAGGAAATTCTGAAAAGTCAGACTCCAAAGGGAGGAGACAAGAAGGAATCCTCCAAGTCATTAGTGCGACAAGGGAGCTTCAC
TATAGAAAAACCCAGCCCAAACATACCCATAGAACTTATTCCCCATATAAATAAACAGACTTCCTCTACTCCTTCTTCTTTAGCATTAAC
ATCTGCAAGTAGAATACGAGAAAGAAGTGAGTCTTTGGATCCTGATTCTAGTATGGACACAACCCTTATTCTAAAAGACACAGAAGCAGT
AATGGCTTTTCTAGAAGCTAAACTACGTGAAGATAATAAAACTGATGAAGGACCAGATACTCCCAGTTATAATAGAGACAATTCTATTTC
ACCAGAATCTGATGTAGATACAGCTAGTACAATCAGTCTGGTTACTGGAGAAACTGAAAGAAAGTCAACCCAAAAGCGAAAGAGTTTCAC
TAGCCTCTATAAAGATAGGTGTTCCACAGGTTCTCCTTCCAAAGATGTTACAAAATCATCATCTTCAGGTGCTAGGGAAAAAATGGAAAA
GAAAACAAAAAGTCGTTCCACAGATGTGGGTTCAAGAGCAGATGGTCGTAAATTTGTTCAGTCCAGTGGGAGAATAAGACAGCCCTCAGT
AGACTTAACAGATGATGACCAAACCTCTAGTGTACCTCATTCTGCCATCTCTGATATTATGTCATCTGATCAAGAAACTTACTCTTGTAA
ACCTCATGGACGGACTCCACTTACCTCAGCTGATGAGCATGTACATTCCAAACTGGAAGGAAGTAAAGTAACGAAATCTAAGACTTCTCC
GGTGGTATCTGGTTCATCTAGTAAATCAACCACCCTTCCAAGGCCACGACCTACCAGGACTTCCCTCTTGCGCAGAGCACGACTTGGTGA
AGCTTCAGACAGTGAACTTGCTGATGCTGACAAAGCATCTGTTGCTTCTGAAGTATCCACAACAAGTTCTACATCAAAACCTCCCACAGG
AAGGCGTAACATCTCTCGGATTGATTTATTGGCTCAGCCTCGTAGAACACGACTTGGCTCACTGTCAGCTCGTAGTGACTCTGAAGCAAC
AATTTCTAGAAGTAGTGCCTCTTCGAGGACCGCAGAAGCCATCATTAGAAGTGGAGCCAGACTAGTACCATCAGATAAATTTTCTCCTAG
AATTAGAGCTAACAGTATCTCTCGACTCTCAGACTCCAAGGTCAAAAGTATGACCTCAGCTCATGGCTCTGCTTCAGTAAATTCAAGATG
GAGGCGCTTTCCTACTGATTATGCTTCCACCTCAGAAGATGAATTTGGATCAAACCGTAATTCCCCTAAACATACCCGTCTACGTACTTC
TCCAGCCCTGAAAACCACTCGCTTGCAGAGCGCTGGATCAGCAATGCCTACTAGTTCTTCATTCAAACACCGGATTAAAGAGCAGGAAGA
CTACATCCGAGATTGGACTGCTCATCGAGAAGAGATAGCCAGGATCAGCCAAGATCTTGCTCTCATTGCTCGGGAGATCAACGATGTAGC
AGGAGAGATAGATTCAGTGACTTCATCAGGCACTGCCCCTAGTACCACAGTAAGCACTGCTGCCACCACCCCTGGCTCTGCCATAGACAC
TAGAGAAGAGTTGGTTGATCGTGTTTTTGATGAAAGCCTCAACTTCCGAAAGATTCCTCCATTAGTTCATTCCAAAACACCAGAAGGAAA
CAACGGTCGATCTGGTGATCCAAGACCTCAAGCAGCAGAGCCTCCCGATCACTTAACAATTACAAGGCGGAGAACCTGGAGCAGGGATGA
AGTCATGGGAGATAATCTGCTGCTGTCATCCGTCTTTCAGTTCTCTAAGAAGATAAGACAATCTATAGATAAGACAGCTGGAAAGATCAG
AATATTATTTAAAGACAAAGATCGGAATTGGGATGACATAGAAAGCAAATTAAGAGCCGAAAGTGAAGTCCCTATTGTGAAAACCTCAAG
CATGGAGATTTCTTCTATCTTACAGGAACTGAAAAGAGTAGAAAAGCAGCTGCAAGCAATCAATGCTATGATTGATCCTGATGGAACTTT
GGAGGCTCTGAACAACATGGGATTTCCCAGTGCTATGTTGCCATCTCCACCGAAACAGAAGTCCAGCCCTGTGAATAACCACCACAGCCC
GGGTCAGACACCAACACTTGGCCAACCAGAAGCTAGGGCTCTTCATCCTGCTGCTGTTTCAGCCGCAGCTGAATTTGAGAATGCTGAATC
TGAGGCTGATTTCAGTATACATTTCAATAGATTCAACCCCGATGGGGAAGAGGAAGATGTTACAGTACAAGAATGACTTTCTCTTGATTG
TTGAAAAATCATTACCTGTGGAATGGCTAGGAATATTGGAAGCAGCATAGTGTTGATGTACGCAAAACAAGACAGCTTGGTCAGCTACAA
TCTTGGAATCCCTGTCTTCTTAATTTTATTTATTTATTTTTGACGTATAATGTAGTATATCAATCCTTTCAAACTATTTAGATAACCACT
TGATGCACAAATAGGAAAAAGCAGATTGTGGCAGTGTCGCCTTTTGTGGTTTTATGATTTTCAAATTGAATTTAATGATTACACCCTTTC
CCTTCATAGATCTTTTTTCTTTTTTTTAAGCCATGCTGTGACCTACAAGCAAACTAAATAGCCAACATTTCTGAACCCCTAAGTCTCCTG
TGCCAAGCTGCTCCCTGAAATGGACTTCTTCATCTGTACAGATTTGTTAAACCATTCTATTTGCTTCTTAATAATAGGATTTATATTAGT
ACTCATTACCATTGGACACAATGACATAAGTACTCTCCACAGTAAAGCAGACCTTTCACAACAGTCACTCTGTGTCCTAAAATTTTCCAA
CATAGATGTGATTTATATAACTTTGTTGATACGTAAATTGTCTTGGGGTTTACGGAAATTAACTATTATGTTTGCACTAAGATTTGCTGG
GAGTGGTAGGTGGACATATCTATATATCAATAAGGACTAACCGTCTTTTTTGTACATAGGAGATTGATAATACTGTATTTGTTTTAAGCC
CACAGTGTTTTACTCCACTTTCAAAAAGATCAATTTGGCACTTTTTTTCATTTTTTTTAATGGAAATAAGATTTGGTCTCTCATTTTAGG
TTAAATGATAACTAGAAAGATTAAACTAGACAGATAGTTTAGGTGGAGTATATTTTTAAAACTCAGAACATGTATATTGGTCCTGTGTTA
CCAAGTTTATATGTGACAGTTGAAAAAGAAATTCCCTTGAAATGATCATGAGGTTAAAATTTTCTTCATTAGGGGACTTGGAGAACCAGT
AGTCGTAAGATTAGTTGATAGTTTCACTCCCAAGCAATGAATTGCTTCTGTGTGTTTCCCTGTAGGACTCAATAGTAAATGCTGTCTGTC
TTACACATTTATAAGGACCCTGCAAGACGACGACAAAGGCCTTTGGCCTGTGCTACTAAACAAGAAGCCTATGAAAAATTTCTTCTTTAA
ACTTGTTTTTTCTCTTTCCAGTAAGTTCACATTTGGATAATTTTAAAAAGAAAAGTAATTACCTTTGTGTTTCCAGAACACTATAATTGG
GGTGTATCTTAATTCAGTTAAATATTATTAGTAGACCTGGATTTTCCCCCTTGACCCCATCAGTCTATAAAGGTTAAACTGCAACTTTTA
TGAAATGGTCTTTAATATTTCCACAATAATCCTGTGCTATATTTGTTTTAAGAAACAAAGTAACTCTATACACTTCAAGACTTTACAGGA
TTTTTTAAATCCTGTATTGTTGGATCAATTAATAAAGATGCAAAAAAACTTTATAGAGATGTAAAAACAAAACTATAATGGATCTCCTAT
TTTTCTTTAAATACAAAAAAAAAAAGGTAAATGAACTATTCTCCTTGTAAAGCTAAATTCCCCATTCTGTCTAATAAAGGAAGACTGAAA
AAAGGTTTTAAAGAACATAAATGGAAAGATACAAATGCTTTGAAGGAATAAACGAAATGTTAAAACAGGGTCAATCCATTTGAAGAAAAA
GTTGGACAAAATAATCAGCATTGCTCCCTCTTTTATTTAATATTTGGGTACTGATTATATCCACATGGAAGTAGAAGGTAAGGAGTTTAG
GAAAATACTAGAATCTACTCTGCTTACATTCTTGTTTAAGTGTTTACACAGTTTGGTTCAATTATAAACATTTGGCCTTTTACTATGTTA
TTTTTATTTTGTATGAATACATTATCCTCCTTATTTATTTTTGTTACATTTATTACTTATGTTATTTTGTTATGCATTTACAACTCCATT

>3497_3497_3_AKT3-CEP170_AKT3_chr1_244006427_ENST00000263826_CEP170_chr1_243336148_ENST00000366544_length(amino acids)=1028AA_BP=
MEERKPLTTSGFHHSEEGTSSSGSKRWVSQWASLAANHTRHDQEERIMEFSAPLPLENETEISESGMTVRSTGSATSLASQGERRRRTLP
QLPNEEKSLESHRAKVVTQRSEIGEKQDTELQEKETPTQVYQKDKQDADRPLSKMNRAVNGETLKTGGDNKTLLHLGSSAPGKEKSETDK
ETSLVKQTLAKLQQQEQREEAQWTPTKLSSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDRVAQSESKRRKAEEILKSQTPKGGDK
KESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSSLALTSASRIRERSESLDPDSSMDTTLILKDTEAVMAFLEAKLREDNKTDE
GPDTPSYNRDNSISPESDVDTASTISLVTGETERKSTQKRKSFTSLYKDRCSTGSPSKDVTKSSSSGAREKMEKKTKSRSTDVGSRADGR
KFVQSSGRIRQPSVDLTDDDQTSSVPHSAISDIMSSDQETYSCKPHGRTPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPR
PTRTSLLRRARLGEASDSELADADKASVASEVSTTSSTSKPPTGRRNISRIDLLAQPRRTRLGSLSARSDSEATISRSSASSRTAEAIIR
SGARLVPSDKFSPRIRANSISRLSDSKVKSMTSAHGSASVNSRWRRFPTDYASTSEDEFGSNRNSPKHTRLRTSPALKTTRLQSAGSAMP
TSSSFKHRIKEQEDYIRDWTAHREEIARISQDLALIAREINDVAGEIDSVTSSGTAPSTTVSTAATTPGSAIDTREELVDRVFDESLNFR
KIPPLVHSKTPEGNNGRSGDPRPQAAEPPDHLTITRRRTWSRDEVMGDNLLLSSVFQFSKKIRQSIDKTAGKIRILFKDKDRNWDDIESK
LRAESEVPIVKTSSMEISSILQELKRVEKQLQAINAMIDPDGTLEALNNMGFPSAMLPSPPKQKSSPVNNHHSPGQTPTLGQPEARALHP

--------------------------------------------------------------
>3497_3497_4_AKT3-CEP170_AKT3_chr1_244006427_ENST00000336199_CEP170_chr1_243336148_ENST00000366542_length(transcript)=5322nt_BP=112nt
CCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAA
GAAGGTTGGGTTCAGAAGAGGGGTGTTTGGAGTAGATGACAATCAGGATTATAATAGGCCTGTTATCAACGAAAAACATAAAGATCTAAT
AAAAGATTGGGCTCTCAGTTCTGCTGCAGCAGTAATGGAAGAAAGAAAACCACTGACTACATCTGGATTTCACCACTCAGAGGAAGGCAC
ATCTTCATCTGGAAGCAAACGTTGGGTTTCACAGTGGGCTAGTTTGGCTGCCAATCATACAAGGCATGATCAAGAAGAAAGGATAATGGA
ATTTTCTGCACCTCTTCCTTTAGAGAATGAGACAGAGATCAGTGAGTCTGGCATGACAGTGAGAAGTACTGGCTCTGCAACTTCCTTGGC
TAGCCAGGGAGAGAGAAGGAGACGAACTCTTCCCCAGCTTCCAAATGAAGAAAAGTCTCTTGAGAGCCACAGAGCAAAGGTTGTAACACA
GAGGTCAGAGATAGGAGAAAAACAAGACACAGAACTTCAGGAGAAAGAAACACCTACACAGGTATACCAGAAAGATAAACAAGATGCTGA
CAGACCCTTGAGTAAAATGAACAGGGCAGTAAATGGAGAGACTCTCAAAACTGGTGGAGATAATAAAACCCTACTTCACTTAGGCAGCTC
TGCTCCTGGAAAAGAGAAAAGTGAAACTGATAAGGAAACTTCTTTGGTAAAGCAAACATTAGCAAAACTTCAACAACAAGAACAAAGGGA
GGAGGCTCAGTGGACACCTACTAAATTGTCTTCCAAAAATGTTTCAGGTCAGACAGATAAATGTAGGGAGGAAACTTTTAAACAAGAATC
ACAACCTCCAGAAAAAAATTCAGGACATTCTACAAGCAAAGGAGACAGAGTGGCACAAAGTGAGAGCAAGAGAAGAAAAGCTGAGGAAAT
TCTGAAAAGTCAGACTCCAAAGGGAGGAGACAAGAAGGAATCCTCCAAGTCATTAGTGCGACAAGGGAGCTTCACTATAGAAAAACCCAG
CCCAAACATACCCATAGAACTTATTCCCCATATAAATAAACAGACTTCCTCTACTCCTTCTTCTTTAGCATTAACATCTGCAAGTAGAAT
ACGAGAAAGAAGTGAGTCTTTGGATCCTGATTCTAGTATGGACACAACCCTTATTCTAAAAGACACAGAAGCAGTAATGGCTTTTCTAGA
AGCTAAACTACGTGAAGATAATAAAACTGATGAAGGACCAGATACTCCCAGTTATAATAGAGACAATTCTATTTCACCAGAATCTGATGT
AGATACAGCTAGTACAATCAGTCTGGTTACTGGAGAAACTGAAAGAAAGTCAACCCAAAAGCGAAAGAGTTTCACTAGCCTCTATAAAGA
TAGGTGTTCCACAGGTTCTCCTTCCAAAGATGTTACAAAATCATCATCTTCAGGTGCTAGGGAAAAAATGGAAAAGAAAACAAAAAGTCG
TTCCACAGATGTGGGTTCAAGAGCAGATGGTCGTAAATTTGTTCAGTCCAGTGGGAGAATAAGACAGCCCTCAGTAGACTTAACAGATGA
TGACCAAACCTCTAGTGTACCTCATTCTGCCATCTCTGATATTATGTCATCTGATCAAGAAACTTACTCTTGTAAACCTCATGGACGGAC
TCCACTTACCTCAGCTGATGAGCATGTACATTCCAAACTGGAAGGAAGTAAAGTAACGAAATCTAAGACTTCTCCGGTGGTATCTGGTTC
ATCTAGTAAATCAACCACCCTTCCAAGGCCACGACCTACCAGGACTTCCCTCTTGCGCAGAGCACGACTTGGTGAAGCTTCAGACAGTGA
ACTTGCTGATGCTGACAAAGCATCTGTTGCTTCTGAAGTATCCACAACAAGTTCTACATCAAAACCTCCCACAGGAAGGCGTAACATCTC
TCGGATTGATTTATTGGCTCAGCCTCGTAGAACACGACTTGGCTCACTGTCAGCTCGTAGTGACTCTGAAGCAACAATTTCTAGAAGTAG
TGCCTCTTCGAGGACCGCAGAAGCCATCATTAGAAGTGGAGCCAGACTAGTACCATCAGATAAATTTTCTCCTAGAATTAGAGCTAACAG
TATCTCTCGACTCTCAGACTCCAAGGTCAAAAGTATGACCTCAGCTCATGGCTCTGCTTCAGTAAATTCAAGATGGAGGCGCTTTCCTAC
TGATTATGCTTCCACCTCAGAAGATGAATTTGGATCAAACCGTAATTCCCCTAAACATACCCGTCTACGTACTTCTCCAGCCCTGAAAAC
CACTCGCTTGCAGAGCGCTGGATCAGCAATGCCTACTAGTTCTTCATTCAAACACCGGATTAAAGAGCAGGAAGACTACATCCGAGATTG
GACTGCTCATCGAGAAGAGATAGCCAGGATCAGCCAAGATCTTGCTCTCATTGCTCGGGAGATCAACGATGTAGCAGGAGAGATAGATTC
AGTGACTTCATCAGGCACTGCCCCTAGTACCACAGTAAGCACTGCTGCCACCACCCCTGGCTCTGCCATAGACACTAGAGAAGAGTTGGT
TGATCGTGTTTTTGATGAAAGCCTCAACTTCCGAAAGATTCCTCCATTAGTTCATTCCAAAACACCAGAAGGAAACAACGGTCGATCTGG
TGATCCAAGACCTCAAGCAGCAGAGCCTCCCGATCACTTAACAATTACAAGGCGGAGAACCTGGAGCAGGGATGAAGTCATGGGAGATAA
TCTGCTGCTGTCATCCGTCTTTCAGTTCTCTAAGAAGATAAGACAATCTATAGATAAGACAGCTGGAAAGATCAGAATATTATTTAAAGA
CAAAGATCGGAATTGGGATGACATAGAAAGCAAATTAAGAGCCGAAAGTGAAGTCCCTATTGTGAAAACCTCAAGCATGGAGATTTCTTC
TATCTTACAGGAACTGAAAAGAGTAGAAAAGCAGCTGCAAGCAATCAATGCTATGATTGATCCTGATGGAACTTTGGAGGCTCTGAACAA
CATGGGATTTCCCAGTGCTATGTTGCCATCTCCACCGAAACAGAAGTCCAGCCCTGTGAATAACCACCACAGCCCGGGTCAGACACCAAC
ACTTGGCCAACCAGAAGCTAGGGCTCTTCATCCTGCTGCTGTTTCAGCCGCAGCTGAATTTGAGAATGCTGAATCTGAGGCTGATTTCAG
TATACATTTCAATAGATTCAACCCCGATGGGGAAGAGGAAGATGTTACAGTACAAGAATGACTTTCTCTTGATTGTTGAAAAATCATTAC
CTGTGGAATGGCTAGGAATATTGGAAGCAGCATAGTGTTGATGTACGCAAAACAAGACAGCTTGGTCAGCTACAATCTTGGAATCCCTGT
CTTCTTAATTTTATTTATTTATTTTTGACGTATAATGTAGTATATCAATCCTTTCAAACTATTTAGATAACCACTTGATGCACAAATAGG
AAAAAGCAGATTGTGGCAGTGTCGCCTTTTGTGGTTTTATGATTTTCAAATTGAATTTAATGATTACACCCTTTCCCTTCATAGATCTTT
TTTCTTTTTTTTAAGCCATGCTGTGACCTACAAGCAAACTAAATAGCCAACATTTCTGAACCCCTAAGTCTCCTGTGCCAAGCTGCTCCC
TGAAATGGACTTCTTCATCTGTACAGATTTGTTAAACCATTCTATTTGCTTCTTAATAATAGGATTTATATTAGTACTCATTACCATTGG
ACACAATGACATAAGTACTCTCCACAGTAAAGCAGACCTTTCACAACAGTCACTCTGTGTCCTAAAATTTTCCAACATAGATGTGATTTA
TATAACTTTGTTGATACGTAAATTGTCTTGGGGTTTACGGAAATTAACTATTATGTTTGCACTAAGATTTGCTGGGAGTGGTAGGTGGAC
ATATCTATATATCAATAAGGACTAACCGTCTTTTTTGTACATAGGAGATTGATAATACTGTATTTGTTTTAAGCCCACAGTGTTTTACTC
CACTTTCAAAAAGATCAATTTGGCACTTTTTTTCATTTTTTTTAATGGAAATAAGATTTGGTCTCTCATTTTAGGTTAAATGATAACTAG
AAAGATTAAACTAGACAGATAGTTTAGGTGGAGTATATTTTTAAAACTCAGAACATGTATATTGGTCCTGTGTTACCAAGTTTATATGTG
ACAGTTGAAAAAGAAATTCCCTTGAAATGATCATGAGGTTAAAATTTTCTTCATTAGGGGACTTGGAGAACCAGTAGTCGTAAGATTAGT
TGATAGTTTCACTCCCAAGCAATGAATTGCTTCTGTGTGTTTCCCTGTAGGACTCAATAGTAAATGCTGTCTGTCTTACACATTTATAAG
GACCCTGCAAGACGACGACAAAGGCCTTTGGCCTGTGCTACTAAACAAGAAGCCTATGAAAAATTTCTTCTTTAAACTTGTTTTTTCTCT
TTCCAGTAAGTTCACATTTGGATAATTTTAAAAAGAAAAGTAATTACCTTTGTGTTTCCAGAACACTATAATTGGGGTGTATCTTAATTC
AGTTAAATATTATTAGTAGACCTGGATTTTCCCCCTTGACCCCATCAGTCTATAAAGGTTAAACTGCAACTTTTATGAAATGGTCTTTAA
TATTTCCACAATAATCCTGTGCTATATTTGTTTTAAGAAACAAAGTAACTCTATACACTTCAAGACTTTACAGGATTTTTTAAATCCTGT
ATTGTTGGATCAATTAATAAAGATGCAAAAAAACTTTATAGAGATGTAAAAACAAAACTATAATGGATCTCCTATTTTTCTTTAAATACA
AAAAAAAAAAGGTAAATGAACTATTCTCCTTGTAAAGCTAAATTCCCCATTCTGTCTAATAAAGGAAGACTGAAAAAAGGTTTTAAAGAA
CATAAATGGAAAGATACAAATGCTTTGAAGGAATAAACGAAATGTTAAAACAGGGTCAATCCATTTGAAGAAAAAGTTGGACAAAATAAT
CAGCATTGCTCCCTCTTTTATTTAATATTTGGGTACTGATTATATCCACATGGAAGTAGAAGGTAAGGAGTTTAGGAAAATACTAGAATC
TACTCTGCTTACATTCTTGTTTAAGTGTTTACACAGTTTGGTTCAATTATAAACATTTGGCCTTTTACTATGTTATTTTTATTTTGTATG
AATACATTATCCTCCTTATTTATTTTTGTTACATTTATTACTTATGTTATTTTGTTATGCATTTACAACTCCATTTTTAAATAAAGTGTT

>3497_3497_4_AKT3-CEP170_AKT3_chr1_244006427_ENST00000336199_CEP170_chr1_243336148_ENST00000366542_length(amino acids)=1028AA_BP=
MEERKPLTTSGFHHSEEGTSSSGSKRWVSQWASLAANHTRHDQEERIMEFSAPLPLENETEISESGMTVRSTGSATSLASQGERRRRTLP
QLPNEEKSLESHRAKVVTQRSEIGEKQDTELQEKETPTQVYQKDKQDADRPLSKMNRAVNGETLKTGGDNKTLLHLGSSAPGKEKSETDK
ETSLVKQTLAKLQQQEQREEAQWTPTKLSSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDRVAQSESKRRKAEEILKSQTPKGGDK
KESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSSLALTSASRIRERSESLDPDSSMDTTLILKDTEAVMAFLEAKLREDNKTDE
GPDTPSYNRDNSISPESDVDTASTISLVTGETERKSTQKRKSFTSLYKDRCSTGSPSKDVTKSSSSGAREKMEKKTKSRSTDVGSRADGR
KFVQSSGRIRQPSVDLTDDDQTSSVPHSAISDIMSSDQETYSCKPHGRTPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPR
PTRTSLLRRARLGEASDSELADADKASVASEVSTTSSTSKPPTGRRNISRIDLLAQPRRTRLGSLSARSDSEATISRSSASSRTAEAIIR
SGARLVPSDKFSPRIRANSISRLSDSKVKSMTSAHGSASVNSRWRRFPTDYASTSEDEFGSNRNSPKHTRLRTSPALKTTRLQSAGSAMP
TSSSFKHRIKEQEDYIRDWTAHREEIARISQDLALIAREINDVAGEIDSVTSSGTAPSTTVSTAATTPGSAIDTREELVDRVFDESLNFR
KIPPLVHSKTPEGNNGRSGDPRPQAAEPPDHLTITRRRTWSRDEVMGDNLLLSSVFQFSKKIRQSIDKTAGKIRILFKDKDRNWDDIESK
LRAESEVPIVKTSSMEISSILQELKRVEKQLQAINAMIDPDGTLEALNNMGFPSAMLPSPPKQKSSPVNNHHSPGQTPTLGQPEARALHP

--------------------------------------------------------------
>3497_3497_5_AKT3-CEP170_AKT3_chr1_244006427_ENST00000336199_CEP170_chr1_243336148_ENST00000366543_length(transcript)=5244nt_BP=112nt
CCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAA
GAAGGTTGGGTTCAGAAGAGGGGTGTTTGGAGTAGATGACAATCAGGATTATAATAGGCCTGTTATCAACGAAAAACATAAAGATCTAAT
AAAAGATTGGGCTCTCAGTTCTGCTGCAGCAGTAATGGAAGAAAGAAAACCACTGACTACATCTGGATTTCACCACTCAGAGGAAGGCAC
ATCTTCATCTGGAAGCAAACGTTGGGTTTCACAGTGGGCTAGTTTGGCTGCCAATCATACAAGGCATGATCAAGAAGAAAGGATAATGGA
ATTTTCTGCACCTCTTCCTTTAGAGAATGAGACAGAGATCAGTGAGTCTGGCATGACAGTGAGAAGTACTGGCTCTGCAACTTCCTTGGC
TAGCCAGGGAGAGAGAAGGAGACGAACTCTTCCCCAGCTTCCAAATGAAGAAAAGTCTCTTGAGAGCCACAGAGCAAAGGTTGTAACACA
GAGGTCAGAGATAGGAGAAAAACAAGACACAGAACTTCAGGAGAAAGAAACACCTACACAGGTATACCAGAAAGATAAACAAGATGCTGA
CAGACCCTTGAGTAAAATGAACAGGGCAGTAAATGGAGAGACTCTCAAAACTGGTGGAGATAATAAAACCCTACTTCACTTAGGCAGCTC
TGCTCCTGGAAAAGAGAAAAGTGAAACTGATAAGGAAACTTCTTTGGTAAAGCAAACATTAGCAAAACTTCAACAACAAGAACAAAGGGA
GGAGGCTCAGTGGACACCTACTAAATTGTCTTCCAAAAATGTTTCAGGTCAGACAGATAAATGTAGGGAGGAAACTTTTAAACAAGAATC
ACAACCTCCAGAAAAAAATTCAGGACATTCTACAAGCAAAGGAGACAGAGTGGCACAAAGTGAGAGCAAGAGAAGAAAAGCTGAGGAAAT
TCTGAAAAGTCAGACTCCAAAGGGAGGAGACAAGAAGGAATCCTCCAAGTCATTAGTGCGACAAGGGAGCTTCACTATAGAAAAACCCAG
CCCAAACATACCCATAGAACTTATTCCCCATATAAATAAACAGACTTCCTCTACTCCTTCTTCTTTAGCATTAACATCTGCAAGTAGAAT
ACGAGAAAGAAGTGAGTCTTTGGATCCTGATTCTAGTATGGACACAACCCTTATTCTAAAAGACACAGAAGCAGTAATGGCTTTTCTAGA
AGCTAAACTACGTGAAGATAATAAAACTGATGAAGGACCAGATACTCCCAGTTATAATAGAGACAATTCTATTTCACCAGAATCTGATGT
AGATACAGCTAGTACAATCAGTCTGGTTACTGGAGAAACTGAAAGAAAGTCAACCCAAAAGCGAAAGAGTTTCACTAGCCTCTATAAAGA
TAGGTGTTCCACAGGTTCTCCTTCCAAAGATGTTACAAAATCATCATCTTCAGGTGCTAGGGAAAAAATGGAAAAGAAAACAAAAAGTCG
TTCCACAGATGTGGGTTCAAGAGCAGATGGTCGTAAATTTGTTCAGTCCAGTGGGAGAATAAGACAGCCCTCAGTAGACTTAACAGATGA
TGACCAAACCTCTAGTGTACCTCATTCTGCCATCTCTGATATTATGTCATCTGATCAAGAAACTTACTCTTGTAAACCTCATGGACGGAC
TCCACTTACCTCAGCTGATGAGCATGTACATTCCAAACTGGAAGGAAGTAAAGTAACGAAATCTAAGACTTCTCCGGTGGTATCTGGTTC
ATCTAGTAAATCAACCACCCTTCCAAGGCCACGACCTACCAGGACTTCCCTCTTGCGCAGAGCACGACTTGGTGAAGCTTCAGACAGTGA
ACTTGCTGATGCTGACAAAGCATCTGTTGCTTCTGAAGTATCCACAACAAGTTCTACATCAAAACCTCCCACAGGAAGGCGTAACATCTC
TCGGATTGATTTATTGGCTCAGCCTCGTAGAACACGACTTGGCTCACTGTCAGCTCGTAGTGACTCTGAAGCAACAATTTCTAGAAGTAG
TGCCTCTTCGAGGACCGCAGAAGCCATCATTAGAAGTGGAGCCAGACTAGTACCATCAGATAAATTTTCTCCTAGAATTAGAGCTAACAG
TATCTCTCGACTCTCAGACTCCAAGGTCAAAAGTATGACCTCAGCTCATGGCTCTGCTTCAGCCCTGAAAACCACTCGCTTGCAGAGCGC
TGGATCAGCAATGCCTACTAGTTCTTCATTCAAACACCGGATTAAAGAGCAGGAAGACTACATCCGAGATTGGACTGCTCATCGAGAAGA
GATAGCCAGGATCAGCCAAGATCTTGCTCTCATTGCTCGGGAGATCAACGATGTAGCAGGAGAGATAGATTCAGTGACTTCATCAGGCAC
TGCCCCTAGTACCACAGTAAGCACTGCTGCCACCACCCCTGGCTCTGCCATAGACACTAGAGAAGAGGTAGGAGATCTTCATGGAGAAAT
GCATAAGTTGGTTGATCGTGTTTTTGATGAAAGCCTCAACTTCCGAAAGATTCCTCCATTAGTTCATTCCAAAACACCAGAAGGAAACAA
CGGTCGATCTGGTGATCCAAGACCTCAAGCAGCAGAGCCTCCCGATCACTTAACAATTACAAGGCGGAGAACCTGGAGCAGGGATGAAGT
CATGGGAGATAATCTGCTGCTGTCATCCGTCTTTCAGTTCTCTAAGAAGATAAGACAATCTATAGATAAGACAGCTGGAAAGATCAGAAT
ATTATTTAAAGACAAAGATCGGAATTGGGATGACATAGAAAGCAAATTAAGAGCCGAAAGTGAAGTCCCTATTGTGAAAACCTCAAGCAT
GGAGATTTCTTCTATCTTACAGGAACTGAAAAGAGTAGAAAAGCAGCTGCAAGCAATCAATGCTATGATTGATCCTGATGGAACTTTGGA
GGCTCTGAACAACATGGGATTTCCCAGTGCTATGTTGCCATCTCCACCGAAACAGAAGTCCAGCCCTGTGAATAACCACCACAGCCCGGG
TCAGACACCAACACTTGGCCAACCAGAAGCTAGGGCTCTTCATCCTGCTGCTGTTTCAGCCGCAGCTGAATTTGAGAATGCTGAATCTGA
GGCTGATTTCAGTATACATTTCAATAGATTCAACCCCGATGGGGAAGAGGAAGATGTTACAGTACAAGAATGACTTTCTCTTGATTGTTG
AAAAATCATTACCTGTGGAATGGCTAGGAATATTGGAAGCAGCATAGTGTTGATGTACGCAAAACAAGACAGCTTGGTCAGCTACAATCT
TGGAATCCCTGTCTTCTTAATTTTATTTATTTATTTTTGACGTATAATGTAGTATATCAATCCTTTCAAACTATTTAGATAACCACTTGA
TGCACAAATAGGAAAAAGCAGATTGTGGCAGTGTCGCCTTTTGTGGTTTTATGATTTTCAAATTGAATTTAATGATTACACCCTTTCCCT
TCATAGATCTTTTTTCTTTTTTTTAAGCCATGCTGTGACCTACAAGCAAACTAAATAGCCAACATTTCTGAACCCCTAAGTCTCCTGTGC
CAAGCTGCTCCCTGAAATGGACTTCTTCATCTGTACAGATTTGTTAAACCATTCTATTTGCTTCTTAATAATAGGATTTATATTAGTACT
CATTACCATTGGACACAATGACATAAGTACTCTCCACAGTAAAGCAGACCTTTCACAACAGTCACTCTGTGTCCTAAAATTTTCCAACAT
AGATGTGATTTATATAACTTTGTTGATACGTAAATTGTCTTGGGGTTTACGGAAATTAACTATTATGTTTGCACTAAGATTTGCTGGGAG
TGGTAGGTGGACATATCTATATATCAATAAGGACTAACCGTCTTTTTTGTACATAGGAGATTGATAATACTGTATTTGTTTTAAGCCCAC
AGTGTTTTACTCCACTTTCAAAAAGATCAATTTGGCACTTTTTTTCATTTTTTTTAATGGAAATAAGATTTGGTCTCTCATTTTAGGTTA
AATGATAACTAGAAAGATTAAACTAGACAGATAGTTTAGGTGGAGTATATTTTTAAAACTCAGAACATGTATATTGGTCCTGTGTTACCA
AGTTTATATGTGACAGTTGAAAAAGAAATTCCCTTGAAATGATCATGAGGTTAAAATTTTCTTCATTAGGGGACTTGGAGAACCAGTAGT
CGTAAGATTAGTTGATAGTTTCACTCCCAAGCAATGAATTGCTTCTGTGTGTTTCCCTGTAGGACTCAATAGTAAATGCTGTCTGTCTTA
CACATTTATAAGGACCCTGCAAGACGACGACAAAGGCCTTTGGCCTGTGCTACTAAACAAGAAGCCTATGAAAAATTTCTTCTTTAAACT
TGTTTTTTCTCTTTCCAGTAAGTTCACATTTGGATAATTTTAAAAAGAAAAGTAATTACCTTTGTGTTTCCAGAACACTATAATTGGGGT
GTATCTTAATTCAGTTAAATATTATTAGTAGACCTGGATTTTCCCCCTTGACCCCATCAGTCTATAAAGGTTAAACTGCAACTTTTATGA
AATGGTCTTTAATATTTCCACAATAATCCTGTGCTATATTTGTTTTAAGAAACAAAGTAACTCTATACACTTCAAGACTTTACAGGATTT
TTTAAATCCTGTATTGTTGGATCAATTAATAAAGATGCAAAAAAACTTTATAGAGATGTAAAAACAAAACTATAATGGATCTCCTATTTT
TCTTTAAATACAAAAAAAAAAAGGTAAATGAACTATTCTCCTTGTAAAGCTAAATTCCCCATTCTGTCTAATAAAGGAAGACTGAAAAAA
GGTTTTAAAGAACATAAATGGAAAGATACAAATGCTTTGAAGGAATAAACGAAATGTTAAAACAGGGTCAATCCATTTGAAGAAAAAGTT
GGACAAAATAATCAGCATTGCTCCCTCTTTTATTTAATATTTGGGTACTGATTATATCCACATGGAAGTAGAAGGTAAGGAGTTTAGGAA
AATACTAGAATCTACTCTGCTTACATTCTTGTTTAAGTGTTTACACAGTTTGGTTCAATTATAAACATTTGGCCTTTTACTATGTTATTT
TTATTTTGTATGAATACATTATCCTCCTTATTTATTTTTGTTACATTTATTACTTATGTTATTTTGTTATGCATTTACAACTCCATTTTT

>3497_3497_5_AKT3-CEP170_AKT3_chr1_244006427_ENST00000336199_CEP170_chr1_243336148_ENST00000366543_length(amino acids)=1002AA_BP=
MEERKPLTTSGFHHSEEGTSSSGSKRWVSQWASLAANHTRHDQEERIMEFSAPLPLENETEISESGMTVRSTGSATSLASQGERRRRTLP
QLPNEEKSLESHRAKVVTQRSEIGEKQDTELQEKETPTQVYQKDKQDADRPLSKMNRAVNGETLKTGGDNKTLLHLGSSAPGKEKSETDK
ETSLVKQTLAKLQQQEQREEAQWTPTKLSSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDRVAQSESKRRKAEEILKSQTPKGGDK
KESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSSLALTSASRIRERSESLDPDSSMDTTLILKDTEAVMAFLEAKLREDNKTDE
GPDTPSYNRDNSISPESDVDTASTISLVTGETERKSTQKRKSFTSLYKDRCSTGSPSKDVTKSSSSGAREKMEKKTKSRSTDVGSRADGR
KFVQSSGRIRQPSVDLTDDDQTSSVPHSAISDIMSSDQETYSCKPHGRTPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPR
PTRTSLLRRARLGEASDSELADADKASVASEVSTTSSTSKPPTGRRNISRIDLLAQPRRTRLGSLSARSDSEATISRSSASSRTAEAIIR
SGARLVPSDKFSPRIRANSISRLSDSKVKSMTSAHGSASALKTTRLQSAGSAMPTSSSFKHRIKEQEDYIRDWTAHREEIARISQDLALI
AREINDVAGEIDSVTSSGTAPSTTVSTAATTPGSAIDTREEVGDLHGEMHKLVDRVFDESLNFRKIPPLVHSKTPEGNNGRSGDPRPQAA
EPPDHLTITRRRTWSRDEVMGDNLLLSSVFQFSKKIRQSIDKTAGKIRILFKDKDRNWDDIESKLRAESEVPIVKTSSMEISSILQELKR
VEKQLQAINAMIDPDGTLEALNNMGFPSAMLPSPPKQKSSPVNNHHSPGQTPTLGQPEARALHPAAVSAAAEFENAESEADFSIHFNRFN

--------------------------------------------------------------
>3497_3497_6_AKT3-CEP170_AKT3_chr1_244006427_ENST00000336199_CEP170_chr1_243336148_ENST00000366544_length(transcript)=5322nt_BP=112nt
CCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAA
GAAGGTTGGGTTCAGAAGAGGGGTGTTTGGAGTAGATGACAATCAGGATTATAATAGGCCTGTTATCAACGAAAAACATAAAGATCTAAT
AAAAGATTGGGCTCTCAGTTCTGCTGCAGCAGTAATGGAAGAAAGAAAACCACTGACTACATCTGGATTTCACCACTCAGAGGAAGGCAC
ATCTTCATCTGGAAGCAAACGTTGGGTTTCACAGTGGGCTAGTTTGGCTGCCAATCATACAAGGCATGATCAAGAAGAAAGGATAATGGA
ATTTTCTGCACCTCTTCCTTTAGAGAATGAGACAGAGATCAGTGAGTCTGGCATGACAGTGAGAAGTACTGGCTCTGCAACTTCCTTGGC
TAGCCAGGGAGAGAGAAGGAGACGAACTCTTCCCCAGCTTCCAAATGAAGAAAAGTCTCTTGAGAGCCACAGAGCAAAGGTTGTAACACA
GAGGTCAGAGATAGGAGAAAAACAAGACACAGAACTTCAGGAGAAAGAAACACCTACACAGGTATACCAGAAAGATAAACAAGATGCTGA
CAGACCCTTGAGTAAAATGAACAGGGCAGTAAATGGAGAGACTCTCAAAACTGGTGGAGATAATAAAACCCTACTTCACTTAGGCAGCTC
TGCTCCTGGAAAAGAGAAAAGTGAAACTGATAAGGAAACTTCTTTGGTAAAGCAAACATTAGCAAAACTTCAACAACAAGAACAAAGGGA
GGAGGCTCAGTGGACACCTACTAAATTGTCTTCCAAAAATGTTTCAGGTCAGACAGATAAATGTAGGGAGGAAACTTTTAAACAAGAATC
ACAACCTCCAGAAAAAAATTCAGGACATTCTACAAGCAAAGGAGACAGAGTGGCACAAAGTGAGAGCAAGAGAAGAAAAGCTGAGGAAAT
TCTGAAAAGTCAGACTCCAAAGGGAGGAGACAAGAAGGAATCCTCCAAGTCATTAGTGCGACAAGGGAGCTTCACTATAGAAAAACCCAG
CCCAAACATACCCATAGAACTTATTCCCCATATAAATAAACAGACTTCCTCTACTCCTTCTTCTTTAGCATTAACATCTGCAAGTAGAAT
ACGAGAAAGAAGTGAGTCTTTGGATCCTGATTCTAGTATGGACACAACCCTTATTCTAAAAGACACAGAAGCAGTAATGGCTTTTCTAGA
AGCTAAACTACGTGAAGATAATAAAACTGATGAAGGACCAGATACTCCCAGTTATAATAGAGACAATTCTATTTCACCAGAATCTGATGT
AGATACAGCTAGTACAATCAGTCTGGTTACTGGAGAAACTGAAAGAAAGTCAACCCAAAAGCGAAAGAGTTTCACTAGCCTCTATAAAGA
TAGGTGTTCCACAGGTTCTCCTTCCAAAGATGTTACAAAATCATCATCTTCAGGTGCTAGGGAAAAAATGGAAAAGAAAACAAAAAGTCG
TTCCACAGATGTGGGTTCAAGAGCAGATGGTCGTAAATTTGTTCAGTCCAGTGGGAGAATAAGACAGCCCTCAGTAGACTTAACAGATGA
TGACCAAACCTCTAGTGTACCTCATTCTGCCATCTCTGATATTATGTCATCTGATCAAGAAACTTACTCTTGTAAACCTCATGGACGGAC
TCCACTTACCTCAGCTGATGAGCATGTACATTCCAAACTGGAAGGAAGTAAAGTAACGAAATCTAAGACTTCTCCGGTGGTATCTGGTTC
ATCTAGTAAATCAACCACCCTTCCAAGGCCACGACCTACCAGGACTTCCCTCTTGCGCAGAGCACGACTTGGTGAAGCTTCAGACAGTGA
ACTTGCTGATGCTGACAAAGCATCTGTTGCTTCTGAAGTATCCACAACAAGTTCTACATCAAAACCTCCCACAGGAAGGCGTAACATCTC
TCGGATTGATTTATTGGCTCAGCCTCGTAGAACACGACTTGGCTCACTGTCAGCTCGTAGTGACTCTGAAGCAACAATTTCTAGAAGTAG
TGCCTCTTCGAGGACCGCAGAAGCCATCATTAGAAGTGGAGCCAGACTAGTACCATCAGATAAATTTTCTCCTAGAATTAGAGCTAACAG
TATCTCTCGACTCTCAGACTCCAAGGTCAAAAGTATGACCTCAGCTCATGGCTCTGCTTCAGTAAATTCAAGATGGAGGCGCTTTCCTAC
TGATTATGCTTCCACCTCAGAAGATGAATTTGGATCAAACCGTAATTCCCCTAAACATACCCGTCTACGTACTTCTCCAGCCCTGAAAAC
CACTCGCTTGCAGAGCGCTGGATCAGCAATGCCTACTAGTTCTTCATTCAAACACCGGATTAAAGAGCAGGAAGACTACATCCGAGATTG
GACTGCTCATCGAGAAGAGATAGCCAGGATCAGCCAAGATCTTGCTCTCATTGCTCGGGAGATCAACGATGTAGCAGGAGAGATAGATTC
AGTGACTTCATCAGGCACTGCCCCTAGTACCACAGTAAGCACTGCTGCCACCACCCCTGGCTCTGCCATAGACACTAGAGAAGAGTTGGT
TGATCGTGTTTTTGATGAAAGCCTCAACTTCCGAAAGATTCCTCCATTAGTTCATTCCAAAACACCAGAAGGAAACAACGGTCGATCTGG
TGATCCAAGACCTCAAGCAGCAGAGCCTCCCGATCACTTAACAATTACAAGGCGGAGAACCTGGAGCAGGGATGAAGTCATGGGAGATAA
TCTGCTGCTGTCATCCGTCTTTCAGTTCTCTAAGAAGATAAGACAATCTATAGATAAGACAGCTGGAAAGATCAGAATATTATTTAAAGA
CAAAGATCGGAATTGGGATGACATAGAAAGCAAATTAAGAGCCGAAAGTGAAGTCCCTATTGTGAAAACCTCAAGCATGGAGATTTCTTC
TATCTTACAGGAACTGAAAAGAGTAGAAAAGCAGCTGCAAGCAATCAATGCTATGATTGATCCTGATGGAACTTTGGAGGCTCTGAACAA
CATGGGATTTCCCAGTGCTATGTTGCCATCTCCACCGAAACAGAAGTCCAGCCCTGTGAATAACCACCACAGCCCGGGTCAGACACCAAC
ACTTGGCCAACCAGAAGCTAGGGCTCTTCATCCTGCTGCTGTTTCAGCCGCAGCTGAATTTGAGAATGCTGAATCTGAGGCTGATTTCAG
TATACATTTCAATAGATTCAACCCCGATGGGGAAGAGGAAGATGTTACAGTACAAGAATGACTTTCTCTTGATTGTTGAAAAATCATTAC
CTGTGGAATGGCTAGGAATATTGGAAGCAGCATAGTGTTGATGTACGCAAAACAAGACAGCTTGGTCAGCTACAATCTTGGAATCCCTGT
CTTCTTAATTTTATTTATTTATTTTTGACGTATAATGTAGTATATCAATCCTTTCAAACTATTTAGATAACCACTTGATGCACAAATAGG
AAAAAGCAGATTGTGGCAGTGTCGCCTTTTGTGGTTTTATGATTTTCAAATTGAATTTAATGATTACACCCTTTCCCTTCATAGATCTTT
TTTCTTTTTTTTAAGCCATGCTGTGACCTACAAGCAAACTAAATAGCCAACATTTCTGAACCCCTAAGTCTCCTGTGCCAAGCTGCTCCC
TGAAATGGACTTCTTCATCTGTACAGATTTGTTAAACCATTCTATTTGCTTCTTAATAATAGGATTTATATTAGTACTCATTACCATTGG
ACACAATGACATAAGTACTCTCCACAGTAAAGCAGACCTTTCACAACAGTCACTCTGTGTCCTAAAATTTTCCAACATAGATGTGATTTA
TATAACTTTGTTGATACGTAAATTGTCTTGGGGTTTACGGAAATTAACTATTATGTTTGCACTAAGATTTGCTGGGAGTGGTAGGTGGAC
ATATCTATATATCAATAAGGACTAACCGTCTTTTTTGTACATAGGAGATTGATAATACTGTATTTGTTTTAAGCCCACAGTGTTTTACTC
CACTTTCAAAAAGATCAATTTGGCACTTTTTTTCATTTTTTTTAATGGAAATAAGATTTGGTCTCTCATTTTAGGTTAAATGATAACTAG
AAAGATTAAACTAGACAGATAGTTTAGGTGGAGTATATTTTTAAAACTCAGAACATGTATATTGGTCCTGTGTTACCAAGTTTATATGTG
ACAGTTGAAAAAGAAATTCCCTTGAAATGATCATGAGGTTAAAATTTTCTTCATTAGGGGACTTGGAGAACCAGTAGTCGTAAGATTAGT
TGATAGTTTCACTCCCAAGCAATGAATTGCTTCTGTGTGTTTCCCTGTAGGACTCAATAGTAAATGCTGTCTGTCTTACACATTTATAAG
GACCCTGCAAGACGACGACAAAGGCCTTTGGCCTGTGCTACTAAACAAGAAGCCTATGAAAAATTTCTTCTTTAAACTTGTTTTTTCTCT
TTCCAGTAAGTTCACATTTGGATAATTTTAAAAAGAAAAGTAATTACCTTTGTGTTTCCAGAACACTATAATTGGGGTGTATCTTAATTC
AGTTAAATATTATTAGTAGACCTGGATTTTCCCCCTTGACCCCATCAGTCTATAAAGGTTAAACTGCAACTTTTATGAAATGGTCTTTAA
TATTTCCACAATAATCCTGTGCTATATTTGTTTTAAGAAACAAAGTAACTCTATACACTTCAAGACTTTACAGGATTTTTTAAATCCTGT
ATTGTTGGATCAATTAATAAAGATGCAAAAAAACTTTATAGAGATGTAAAAACAAAACTATAATGGATCTCCTATTTTTCTTTAAATACA
AAAAAAAAAAGGTAAATGAACTATTCTCCTTGTAAAGCTAAATTCCCCATTCTGTCTAATAAAGGAAGACTGAAAAAAGGTTTTAAAGAA
CATAAATGGAAAGATACAAATGCTTTGAAGGAATAAACGAAATGTTAAAACAGGGTCAATCCATTTGAAGAAAAAGTTGGACAAAATAAT
CAGCATTGCTCCCTCTTTTATTTAATATTTGGGTACTGATTATATCCACATGGAAGTAGAAGGTAAGGAGTTTAGGAAAATACTAGAATC
TACTCTGCTTACATTCTTGTTTAAGTGTTTACACAGTTTGGTTCAATTATAAACATTTGGCCTTTTACTATGTTATTTTTATTTTGTATG
AATACATTATCCTCCTTATTTATTTTTGTTACATTTATTACTTATGTTATTTTGTTATGCATTTACAACTCCATTTTTAAATAAAGTGTT

>3497_3497_6_AKT3-CEP170_AKT3_chr1_244006427_ENST00000336199_CEP170_chr1_243336148_ENST00000366544_length(amino acids)=1028AA_BP=
MEERKPLTTSGFHHSEEGTSSSGSKRWVSQWASLAANHTRHDQEERIMEFSAPLPLENETEISESGMTVRSTGSATSLASQGERRRRTLP
QLPNEEKSLESHRAKVVTQRSEIGEKQDTELQEKETPTQVYQKDKQDADRPLSKMNRAVNGETLKTGGDNKTLLHLGSSAPGKEKSETDK
ETSLVKQTLAKLQQQEQREEAQWTPTKLSSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDRVAQSESKRRKAEEILKSQTPKGGDK
KESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSSLALTSASRIRERSESLDPDSSMDTTLILKDTEAVMAFLEAKLREDNKTDE
GPDTPSYNRDNSISPESDVDTASTISLVTGETERKSTQKRKSFTSLYKDRCSTGSPSKDVTKSSSSGAREKMEKKTKSRSTDVGSRADGR
KFVQSSGRIRQPSVDLTDDDQTSSVPHSAISDIMSSDQETYSCKPHGRTPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPR
PTRTSLLRRARLGEASDSELADADKASVASEVSTTSSTSKPPTGRRNISRIDLLAQPRRTRLGSLSARSDSEATISRSSASSRTAEAIIR
SGARLVPSDKFSPRIRANSISRLSDSKVKSMTSAHGSASVNSRWRRFPTDYASTSEDEFGSNRNSPKHTRLRTSPALKTTRLQSAGSAMP
TSSSFKHRIKEQEDYIRDWTAHREEIARISQDLALIAREINDVAGEIDSVTSSGTAPSTTVSTAATTPGSAIDTREELVDRVFDESLNFR
KIPPLVHSKTPEGNNGRSGDPRPQAAEPPDHLTITRRRTWSRDEVMGDNLLLSSVFQFSKKIRQSIDKTAGKIRILFKDKDRNWDDIESK
LRAESEVPIVKTSSMEISSILQELKRVEKQLQAINAMIDPDGTLEALNNMGFPSAMLPSPPKQKSSPVNNHHSPGQTPTLGQPEARALHP

--------------------------------------------------------------
>3497_3497_7_AKT3-CEP170_AKT3_chr1_244006427_ENST00000366539_CEP170_chr1_243336148_ENST00000366542_length(transcript)=5457nt_BP=247nt
CCCTCTCCTCCCCCCGCCCCCCCCCGGCTCCATCCTCCGCCGCCGCCCGAGCAGCTGCGGGGCCGCCACCGCCGCCGCCGCCGTTGCAGG
CTGAGTCATCACTAGAGAGTGGGAAGGGCAGCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTG
GGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGTGTTTGGAGTAGATGACAATCA
GGATTATAATAGGCCTGTTATCAACGAAAAACATAAAGATCTAATAAAAGATTGGGCTCTCAGTTCTGCTGCAGCAGTAATGGAAGAAAG
AAAACCACTGACTACATCTGGATTTCACCACTCAGAGGAAGGCACATCTTCATCTGGAAGCAAACGTTGGGTTTCACAGTGGGCTAGTTT
GGCTGCCAATCATACAAGGCATGATCAAGAAGAAAGGATAATGGAATTTTCTGCACCTCTTCCTTTAGAGAATGAGACAGAGATCAGTGA
GTCTGGCATGACAGTGAGAAGTACTGGCTCTGCAACTTCCTTGGCTAGCCAGGGAGAGAGAAGGAGACGAACTCTTCCCCAGCTTCCAAA
TGAAGAAAAGTCTCTTGAGAGCCACAGAGCAAAGGTTGTAACACAGAGGTCAGAGATAGGAGAAAAACAAGACACAGAACTTCAGGAGAA
AGAAACACCTACACAGGTATACCAGAAAGATAAACAAGATGCTGACAGACCCTTGAGTAAAATGAACAGGGCAGTAAATGGAGAGACTCT
CAAAACTGGTGGAGATAATAAAACCCTACTTCACTTAGGCAGCTCTGCTCCTGGAAAAGAGAAAAGTGAAACTGATAAGGAAACTTCTTT
GGTAAAGCAAACATTAGCAAAACTTCAACAACAAGAACAAAGGGAGGAGGCTCAGTGGACACCTACTAAATTGTCTTCCAAAAATGTTTC
AGGTCAGACAGATAAATGTAGGGAGGAAACTTTTAAACAAGAATCACAACCTCCAGAAAAAAATTCAGGACATTCTACAAGCAAAGGAGA
CAGAGTGGCACAAAGTGAGAGCAAGAGAAGAAAAGCTGAGGAAATTCTGAAAAGTCAGACTCCAAAGGGAGGAGACAAGAAGGAATCCTC
CAAGTCATTAGTGCGACAAGGGAGCTTCACTATAGAAAAACCCAGCCCAAACATACCCATAGAACTTATTCCCCATATAAATAAACAGAC
TTCCTCTACTCCTTCTTCTTTAGCATTAACATCTGCAAGTAGAATACGAGAAAGAAGTGAGTCTTTGGATCCTGATTCTAGTATGGACAC
AACCCTTATTCTAAAAGACACAGAAGCAGTAATGGCTTTTCTAGAAGCTAAACTACGTGAAGATAATAAAACTGATGAAGGACCAGATAC
TCCCAGTTATAATAGAGACAATTCTATTTCACCAGAATCTGATGTAGATACAGCTAGTACAATCAGTCTGGTTACTGGAGAAACTGAAAG
AAAGTCAACCCAAAAGCGAAAGAGTTTCACTAGCCTCTATAAAGATAGGTGTTCCACAGGTTCTCCTTCCAAAGATGTTACAAAATCATC
ATCTTCAGGTGCTAGGGAAAAAATGGAAAAGAAAACAAAAAGTCGTTCCACAGATGTGGGTTCAAGAGCAGATGGTCGTAAATTTGTTCA
GTCCAGTGGGAGAATAAGACAGCCCTCAGTAGACTTAACAGATGATGACCAAACCTCTAGTGTACCTCATTCTGCCATCTCTGATATTAT
GTCATCTGATCAAGAAACTTACTCTTGTAAACCTCATGGACGGACTCCACTTACCTCAGCTGATGAGCATGTACATTCCAAACTGGAAGG
AAGTAAAGTAACGAAATCTAAGACTTCTCCGGTGGTATCTGGTTCATCTAGTAAATCAACCACCCTTCCAAGGCCACGACCTACCAGGAC
TTCCCTCTTGCGCAGAGCACGACTTGGTGAAGCTTCAGACAGTGAACTTGCTGATGCTGACAAAGCATCTGTTGCTTCTGAAGTATCCAC
AACAAGTTCTACATCAAAACCTCCCACAGGAAGGCGTAACATCTCTCGGATTGATTTATTGGCTCAGCCTCGTAGAACACGACTTGGCTC
ACTGTCAGCTCGTAGTGACTCTGAAGCAACAATTTCTAGAAGTAGTGCCTCTTCGAGGACCGCAGAAGCCATCATTAGAAGTGGAGCCAG
ACTAGTACCATCAGATAAATTTTCTCCTAGAATTAGAGCTAACAGTATCTCTCGACTCTCAGACTCCAAGGTCAAAAGTATGACCTCAGC
TCATGGCTCTGCTTCAGTAAATTCAAGATGGAGGCGCTTTCCTACTGATTATGCTTCCACCTCAGAAGATGAATTTGGATCAAACCGTAA
TTCCCCTAAACATACCCGTCTACGTACTTCTCCAGCCCTGAAAACCACTCGCTTGCAGAGCGCTGGATCAGCAATGCCTACTAGTTCTTC
ATTCAAACACCGGATTAAAGAGCAGGAAGACTACATCCGAGATTGGACTGCTCATCGAGAAGAGATAGCCAGGATCAGCCAAGATCTTGC
TCTCATTGCTCGGGAGATCAACGATGTAGCAGGAGAGATAGATTCAGTGACTTCATCAGGCACTGCCCCTAGTACCACAGTAAGCACTGC
TGCCACCACCCCTGGCTCTGCCATAGACACTAGAGAAGAGTTGGTTGATCGTGTTTTTGATGAAAGCCTCAACTTCCGAAAGATTCCTCC
ATTAGTTCATTCCAAAACACCAGAAGGAAACAACGGTCGATCTGGTGATCCAAGACCTCAAGCAGCAGAGCCTCCCGATCACTTAACAAT
TACAAGGCGGAGAACCTGGAGCAGGGATGAAGTCATGGGAGATAATCTGCTGCTGTCATCCGTCTTTCAGTTCTCTAAGAAGATAAGACA
ATCTATAGATAAGACAGCTGGAAAGATCAGAATATTATTTAAAGACAAAGATCGGAATTGGGATGACATAGAAAGCAAATTAAGAGCCGA
AAGTGAAGTCCCTATTGTGAAAACCTCAAGCATGGAGATTTCTTCTATCTTACAGGAACTGAAAAGAGTAGAAAAGCAGCTGCAAGCAAT
CAATGCTATGATTGATCCTGATGGAACTTTGGAGGCTCTGAACAACATGGGATTTCCCAGTGCTATGTTGCCATCTCCACCGAAACAGAA
GTCCAGCCCTGTGAATAACCACCACAGCCCGGGTCAGACACCAACACTTGGCCAACCAGAAGCTAGGGCTCTTCATCCTGCTGCTGTTTC
AGCCGCAGCTGAATTTGAGAATGCTGAATCTGAGGCTGATTTCAGTATACATTTCAATAGATTCAACCCCGATGGGGAAGAGGAAGATGT
TACAGTACAAGAATGACTTTCTCTTGATTGTTGAAAAATCATTACCTGTGGAATGGCTAGGAATATTGGAAGCAGCATAGTGTTGATGTA
CGCAAAACAAGACAGCTTGGTCAGCTACAATCTTGGAATCCCTGTCTTCTTAATTTTATTTATTTATTTTTGACGTATAATGTAGTATAT
CAATCCTTTCAAACTATTTAGATAACCACTTGATGCACAAATAGGAAAAAGCAGATTGTGGCAGTGTCGCCTTTTGTGGTTTTATGATTT
TCAAATTGAATTTAATGATTACACCCTTTCCCTTCATAGATCTTTTTTCTTTTTTTTAAGCCATGCTGTGACCTACAAGCAAACTAAATA
GCCAACATTTCTGAACCCCTAAGTCTCCTGTGCCAAGCTGCTCCCTGAAATGGACTTCTTCATCTGTACAGATTTGTTAAACCATTCTAT
TTGCTTCTTAATAATAGGATTTATATTAGTACTCATTACCATTGGACACAATGACATAAGTACTCTCCACAGTAAAGCAGACCTTTCACA
ACAGTCACTCTGTGTCCTAAAATTTTCCAACATAGATGTGATTTATATAACTTTGTTGATACGTAAATTGTCTTGGGGTTTACGGAAATT
AACTATTATGTTTGCACTAAGATTTGCTGGGAGTGGTAGGTGGACATATCTATATATCAATAAGGACTAACCGTCTTTTTTGTACATAGG
AGATTGATAATACTGTATTTGTTTTAAGCCCACAGTGTTTTACTCCACTTTCAAAAAGATCAATTTGGCACTTTTTTTCATTTTTTTTAA
TGGAAATAAGATTTGGTCTCTCATTTTAGGTTAAATGATAACTAGAAAGATTAAACTAGACAGATAGTTTAGGTGGAGTATATTTTTAAA
ACTCAGAACATGTATATTGGTCCTGTGTTACCAAGTTTATATGTGACAGTTGAAAAAGAAATTCCCTTGAAATGATCATGAGGTTAAAAT
TTTCTTCATTAGGGGACTTGGAGAACCAGTAGTCGTAAGATTAGTTGATAGTTTCACTCCCAAGCAATGAATTGCTTCTGTGTGTTTCCC
TGTAGGACTCAATAGTAAATGCTGTCTGTCTTACACATTTATAAGGACCCTGCAAGACGACGACAAAGGCCTTTGGCCTGTGCTACTAAA
CAAGAAGCCTATGAAAAATTTCTTCTTTAAACTTGTTTTTTCTCTTTCCAGTAAGTTCACATTTGGATAATTTTAAAAAGAAAAGTAATT
ACCTTTGTGTTTCCAGAACACTATAATTGGGGTGTATCTTAATTCAGTTAAATATTATTAGTAGACCTGGATTTTCCCCCTTGACCCCAT
CAGTCTATAAAGGTTAAACTGCAACTTTTATGAAATGGTCTTTAATATTTCCACAATAATCCTGTGCTATATTTGTTTTAAGAAACAAAG
TAACTCTATACACTTCAAGACTTTACAGGATTTTTTAAATCCTGTATTGTTGGATCAATTAATAAAGATGCAAAAAAACTTTATAGAGAT
GTAAAAACAAAACTATAATGGATCTCCTATTTTTCTTTAAATACAAAAAAAAAAAGGTAAATGAACTATTCTCCTTGTAAAGCTAAATTC
CCCATTCTGTCTAATAAAGGAAGACTGAAAAAAGGTTTTAAAGAACATAAATGGAAAGATACAAATGCTTTGAAGGAATAAACGAAATGT
TAAAACAGGGTCAATCCATTTGAAGAAAAAGTTGGACAAAATAATCAGCATTGCTCCCTCTTTTATTTAATATTTGGGTACTGATTATAT
CCACATGGAAGTAGAAGGTAAGGAGTTTAGGAAAATACTAGAATCTACTCTGCTTACATTCTTGTTTAAGTGTTTACACAGTTTGGTTCA
ATTATAAACATTTGGCCTTTTACTATGTTATTTTTATTTTGTATGAATACATTATCCTCCTTATTTATTTTTGTTACATTTATTACTTAT

>3497_3497_7_AKT3-CEP170_AKT3_chr1_244006427_ENST00000366539_CEP170_chr1_243336148_ENST00000366542_length(amino acids)=1028AA_BP=
MEERKPLTTSGFHHSEEGTSSSGSKRWVSQWASLAANHTRHDQEERIMEFSAPLPLENETEISESGMTVRSTGSATSLASQGERRRRTLP
QLPNEEKSLESHRAKVVTQRSEIGEKQDTELQEKETPTQVYQKDKQDADRPLSKMNRAVNGETLKTGGDNKTLLHLGSSAPGKEKSETDK
ETSLVKQTLAKLQQQEQREEAQWTPTKLSSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDRVAQSESKRRKAEEILKSQTPKGGDK
KESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSSLALTSASRIRERSESLDPDSSMDTTLILKDTEAVMAFLEAKLREDNKTDE
GPDTPSYNRDNSISPESDVDTASTISLVTGETERKSTQKRKSFTSLYKDRCSTGSPSKDVTKSSSSGAREKMEKKTKSRSTDVGSRADGR
KFVQSSGRIRQPSVDLTDDDQTSSVPHSAISDIMSSDQETYSCKPHGRTPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPR
PTRTSLLRRARLGEASDSELADADKASVASEVSTTSSTSKPPTGRRNISRIDLLAQPRRTRLGSLSARSDSEATISRSSASSRTAEAIIR
SGARLVPSDKFSPRIRANSISRLSDSKVKSMTSAHGSASVNSRWRRFPTDYASTSEDEFGSNRNSPKHTRLRTSPALKTTRLQSAGSAMP
TSSSFKHRIKEQEDYIRDWTAHREEIARISQDLALIAREINDVAGEIDSVTSSGTAPSTTVSTAATTPGSAIDTREELVDRVFDESLNFR
KIPPLVHSKTPEGNNGRSGDPRPQAAEPPDHLTITRRRTWSRDEVMGDNLLLSSVFQFSKKIRQSIDKTAGKIRILFKDKDRNWDDIESK
LRAESEVPIVKTSSMEISSILQELKRVEKQLQAINAMIDPDGTLEALNNMGFPSAMLPSPPKQKSSPVNNHHSPGQTPTLGQPEARALHP

--------------------------------------------------------------
>3497_3497_8_AKT3-CEP170_AKT3_chr1_244006427_ENST00000366539_CEP170_chr1_243336148_ENST00000366543_length(transcript)=5379nt_BP=247nt
CCCTCTCCTCCCCCCGCCCCCCCCCGGCTCCATCCTCCGCCGCCGCCCGAGCAGCTGCGGGGCCGCCACCGCCGCCGCCGCCGTTGCAGG
CTGAGTCATCACTAGAGAGTGGGAAGGGCAGCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTG
GGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGTGTTTGGAGTAGATGACAATCA
GGATTATAATAGGCCTGTTATCAACGAAAAACATAAAGATCTAATAAAAGATTGGGCTCTCAGTTCTGCTGCAGCAGTAATGGAAGAAAG
AAAACCACTGACTACATCTGGATTTCACCACTCAGAGGAAGGCACATCTTCATCTGGAAGCAAACGTTGGGTTTCACAGTGGGCTAGTTT
GGCTGCCAATCATACAAGGCATGATCAAGAAGAAAGGATAATGGAATTTTCTGCACCTCTTCCTTTAGAGAATGAGACAGAGATCAGTGA
GTCTGGCATGACAGTGAGAAGTACTGGCTCTGCAACTTCCTTGGCTAGCCAGGGAGAGAGAAGGAGACGAACTCTTCCCCAGCTTCCAAA
TGAAGAAAAGTCTCTTGAGAGCCACAGAGCAAAGGTTGTAACACAGAGGTCAGAGATAGGAGAAAAACAAGACACAGAACTTCAGGAGAA
AGAAACACCTACACAGGTATACCAGAAAGATAAACAAGATGCTGACAGACCCTTGAGTAAAATGAACAGGGCAGTAAATGGAGAGACTCT
CAAAACTGGTGGAGATAATAAAACCCTACTTCACTTAGGCAGCTCTGCTCCTGGAAAAGAGAAAAGTGAAACTGATAAGGAAACTTCTTT
GGTAAAGCAAACATTAGCAAAACTTCAACAACAAGAACAAAGGGAGGAGGCTCAGTGGACACCTACTAAATTGTCTTCCAAAAATGTTTC
AGGTCAGACAGATAAATGTAGGGAGGAAACTTTTAAACAAGAATCACAACCTCCAGAAAAAAATTCAGGACATTCTACAAGCAAAGGAGA
CAGAGTGGCACAAAGTGAGAGCAAGAGAAGAAAAGCTGAGGAAATTCTGAAAAGTCAGACTCCAAAGGGAGGAGACAAGAAGGAATCCTC
CAAGTCATTAGTGCGACAAGGGAGCTTCACTATAGAAAAACCCAGCCCAAACATACCCATAGAACTTATTCCCCATATAAATAAACAGAC
TTCCTCTACTCCTTCTTCTTTAGCATTAACATCTGCAAGTAGAATACGAGAAAGAAGTGAGTCTTTGGATCCTGATTCTAGTATGGACAC
AACCCTTATTCTAAAAGACACAGAAGCAGTAATGGCTTTTCTAGAAGCTAAACTACGTGAAGATAATAAAACTGATGAAGGACCAGATAC
TCCCAGTTATAATAGAGACAATTCTATTTCACCAGAATCTGATGTAGATACAGCTAGTACAATCAGTCTGGTTACTGGAGAAACTGAAAG
AAAGTCAACCCAAAAGCGAAAGAGTTTCACTAGCCTCTATAAAGATAGGTGTTCCACAGGTTCTCCTTCCAAAGATGTTACAAAATCATC
ATCTTCAGGTGCTAGGGAAAAAATGGAAAAGAAAACAAAAAGTCGTTCCACAGATGTGGGTTCAAGAGCAGATGGTCGTAAATTTGTTCA
GTCCAGTGGGAGAATAAGACAGCCCTCAGTAGACTTAACAGATGATGACCAAACCTCTAGTGTACCTCATTCTGCCATCTCTGATATTAT
GTCATCTGATCAAGAAACTTACTCTTGTAAACCTCATGGACGGACTCCACTTACCTCAGCTGATGAGCATGTACATTCCAAACTGGAAGG
AAGTAAAGTAACGAAATCTAAGACTTCTCCGGTGGTATCTGGTTCATCTAGTAAATCAACCACCCTTCCAAGGCCACGACCTACCAGGAC
TTCCCTCTTGCGCAGAGCACGACTTGGTGAAGCTTCAGACAGTGAACTTGCTGATGCTGACAAAGCATCTGTTGCTTCTGAAGTATCCAC
AACAAGTTCTACATCAAAACCTCCCACAGGAAGGCGTAACATCTCTCGGATTGATTTATTGGCTCAGCCTCGTAGAACACGACTTGGCTC
ACTGTCAGCTCGTAGTGACTCTGAAGCAACAATTTCTAGAAGTAGTGCCTCTTCGAGGACCGCAGAAGCCATCATTAGAAGTGGAGCCAG
ACTAGTACCATCAGATAAATTTTCTCCTAGAATTAGAGCTAACAGTATCTCTCGACTCTCAGACTCCAAGGTCAAAAGTATGACCTCAGC
TCATGGCTCTGCTTCAGCCCTGAAAACCACTCGCTTGCAGAGCGCTGGATCAGCAATGCCTACTAGTTCTTCATTCAAACACCGGATTAA
AGAGCAGGAAGACTACATCCGAGATTGGACTGCTCATCGAGAAGAGATAGCCAGGATCAGCCAAGATCTTGCTCTCATTGCTCGGGAGAT
CAACGATGTAGCAGGAGAGATAGATTCAGTGACTTCATCAGGCACTGCCCCTAGTACCACAGTAAGCACTGCTGCCACCACCCCTGGCTC
TGCCATAGACACTAGAGAAGAGGTAGGAGATCTTCATGGAGAAATGCATAAGTTGGTTGATCGTGTTTTTGATGAAAGCCTCAACTTCCG
AAAGATTCCTCCATTAGTTCATTCCAAAACACCAGAAGGAAACAACGGTCGATCTGGTGATCCAAGACCTCAAGCAGCAGAGCCTCCCGA
TCACTTAACAATTACAAGGCGGAGAACCTGGAGCAGGGATGAAGTCATGGGAGATAATCTGCTGCTGTCATCCGTCTTTCAGTTCTCTAA
GAAGATAAGACAATCTATAGATAAGACAGCTGGAAAGATCAGAATATTATTTAAAGACAAAGATCGGAATTGGGATGACATAGAAAGCAA
ATTAAGAGCCGAAAGTGAAGTCCCTATTGTGAAAACCTCAAGCATGGAGATTTCTTCTATCTTACAGGAACTGAAAAGAGTAGAAAAGCA
GCTGCAAGCAATCAATGCTATGATTGATCCTGATGGAACTTTGGAGGCTCTGAACAACATGGGATTTCCCAGTGCTATGTTGCCATCTCC
ACCGAAACAGAAGTCCAGCCCTGTGAATAACCACCACAGCCCGGGTCAGACACCAACACTTGGCCAACCAGAAGCTAGGGCTCTTCATCC
TGCTGCTGTTTCAGCCGCAGCTGAATTTGAGAATGCTGAATCTGAGGCTGATTTCAGTATACATTTCAATAGATTCAACCCCGATGGGGA
AGAGGAAGATGTTACAGTACAAGAATGACTTTCTCTTGATTGTTGAAAAATCATTACCTGTGGAATGGCTAGGAATATTGGAAGCAGCAT
AGTGTTGATGTACGCAAAACAAGACAGCTTGGTCAGCTACAATCTTGGAATCCCTGTCTTCTTAATTTTATTTATTTATTTTTGACGTAT
AATGTAGTATATCAATCCTTTCAAACTATTTAGATAACCACTTGATGCACAAATAGGAAAAAGCAGATTGTGGCAGTGTCGCCTTTTGTG
GTTTTATGATTTTCAAATTGAATTTAATGATTACACCCTTTCCCTTCATAGATCTTTTTTCTTTTTTTTAAGCCATGCTGTGACCTACAA
GCAAACTAAATAGCCAACATTTCTGAACCCCTAAGTCTCCTGTGCCAAGCTGCTCCCTGAAATGGACTTCTTCATCTGTACAGATTTGTT
AAACCATTCTATTTGCTTCTTAATAATAGGATTTATATTAGTACTCATTACCATTGGACACAATGACATAAGTACTCTCCACAGTAAAGC
AGACCTTTCACAACAGTCACTCTGTGTCCTAAAATTTTCCAACATAGATGTGATTTATATAACTTTGTTGATACGTAAATTGTCTTGGGG
TTTACGGAAATTAACTATTATGTTTGCACTAAGATTTGCTGGGAGTGGTAGGTGGACATATCTATATATCAATAAGGACTAACCGTCTTT
TTTGTACATAGGAGATTGATAATACTGTATTTGTTTTAAGCCCACAGTGTTTTACTCCACTTTCAAAAAGATCAATTTGGCACTTTTTTT
CATTTTTTTTAATGGAAATAAGATTTGGTCTCTCATTTTAGGTTAAATGATAACTAGAAAGATTAAACTAGACAGATAGTTTAGGTGGAG
TATATTTTTAAAACTCAGAACATGTATATTGGTCCTGTGTTACCAAGTTTATATGTGACAGTTGAAAAAGAAATTCCCTTGAAATGATCA
TGAGGTTAAAATTTTCTTCATTAGGGGACTTGGAGAACCAGTAGTCGTAAGATTAGTTGATAGTTTCACTCCCAAGCAATGAATTGCTTC
TGTGTGTTTCCCTGTAGGACTCAATAGTAAATGCTGTCTGTCTTACACATTTATAAGGACCCTGCAAGACGACGACAAAGGCCTTTGGCC
TGTGCTACTAAACAAGAAGCCTATGAAAAATTTCTTCTTTAAACTTGTTTTTTCTCTTTCCAGTAAGTTCACATTTGGATAATTTTAAAA
AGAAAAGTAATTACCTTTGTGTTTCCAGAACACTATAATTGGGGTGTATCTTAATTCAGTTAAATATTATTAGTAGACCTGGATTTTCCC
CCTTGACCCCATCAGTCTATAAAGGTTAAACTGCAACTTTTATGAAATGGTCTTTAATATTTCCACAATAATCCTGTGCTATATTTGTTT
TAAGAAACAAAGTAACTCTATACACTTCAAGACTTTACAGGATTTTTTAAATCCTGTATTGTTGGATCAATTAATAAAGATGCAAAAAAA
CTTTATAGAGATGTAAAAACAAAACTATAATGGATCTCCTATTTTTCTTTAAATACAAAAAAAAAAAGGTAAATGAACTATTCTCCTTGT
AAAGCTAAATTCCCCATTCTGTCTAATAAAGGAAGACTGAAAAAAGGTTTTAAAGAACATAAATGGAAAGATACAAATGCTTTGAAGGAA
TAAACGAAATGTTAAAACAGGGTCAATCCATTTGAAGAAAAAGTTGGACAAAATAATCAGCATTGCTCCCTCTTTTATTTAATATTTGGG
TACTGATTATATCCACATGGAAGTAGAAGGTAAGGAGTTTAGGAAAATACTAGAATCTACTCTGCTTACATTCTTGTTTAAGTGTTTACA
CAGTTTGGTTCAATTATAAACATTTGGCCTTTTACTATGTTATTTTTATTTTGTATGAATACATTATCCTCCTTATTTATTTTTGTTACA

>3497_3497_8_AKT3-CEP170_AKT3_chr1_244006427_ENST00000366539_CEP170_chr1_243336148_ENST00000366543_length(amino acids)=1002AA_BP=
MEERKPLTTSGFHHSEEGTSSSGSKRWVSQWASLAANHTRHDQEERIMEFSAPLPLENETEISESGMTVRSTGSATSLASQGERRRRTLP
QLPNEEKSLESHRAKVVTQRSEIGEKQDTELQEKETPTQVYQKDKQDADRPLSKMNRAVNGETLKTGGDNKTLLHLGSSAPGKEKSETDK
ETSLVKQTLAKLQQQEQREEAQWTPTKLSSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDRVAQSESKRRKAEEILKSQTPKGGDK
KESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSSLALTSASRIRERSESLDPDSSMDTTLILKDTEAVMAFLEAKLREDNKTDE
GPDTPSYNRDNSISPESDVDTASTISLVTGETERKSTQKRKSFTSLYKDRCSTGSPSKDVTKSSSSGAREKMEKKTKSRSTDVGSRADGR
KFVQSSGRIRQPSVDLTDDDQTSSVPHSAISDIMSSDQETYSCKPHGRTPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPR
PTRTSLLRRARLGEASDSELADADKASVASEVSTTSSTSKPPTGRRNISRIDLLAQPRRTRLGSLSARSDSEATISRSSASSRTAEAIIR
SGARLVPSDKFSPRIRANSISRLSDSKVKSMTSAHGSASALKTTRLQSAGSAMPTSSSFKHRIKEQEDYIRDWTAHREEIARISQDLALI
AREINDVAGEIDSVTSSGTAPSTTVSTAATTPGSAIDTREEVGDLHGEMHKLVDRVFDESLNFRKIPPLVHSKTPEGNNGRSGDPRPQAA
EPPDHLTITRRRTWSRDEVMGDNLLLSSVFQFSKKIRQSIDKTAGKIRILFKDKDRNWDDIESKLRAESEVPIVKTSSMEISSILQELKR
VEKQLQAINAMIDPDGTLEALNNMGFPSAMLPSPPKQKSSPVNNHHSPGQTPTLGQPEARALHPAAVSAAAEFENAESEADFSIHFNRFN

--------------------------------------------------------------
>3497_3497_9_AKT3-CEP170_AKT3_chr1_244006427_ENST00000366539_CEP170_chr1_243336148_ENST00000366544_length(transcript)=5457nt_BP=247nt
CCCTCTCCTCCCCCCGCCCCCCCCCGGCTCCATCCTCCGCCGCCGCCCGAGCAGCTGCGGGGCCGCCACCGCCGCCGCCGCCGTTGCAGG
CTGAGTCATCACTAGAGAGTGGGAAGGGCAGCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTG
GGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGTGTTTGGAGTAGATGACAATCA
GGATTATAATAGGCCTGTTATCAACGAAAAACATAAAGATCTAATAAAAGATTGGGCTCTCAGTTCTGCTGCAGCAGTAATGGAAGAAAG
AAAACCACTGACTACATCTGGATTTCACCACTCAGAGGAAGGCACATCTTCATCTGGAAGCAAACGTTGGGTTTCACAGTGGGCTAGTTT
GGCTGCCAATCATACAAGGCATGATCAAGAAGAAAGGATAATGGAATTTTCTGCACCTCTTCCTTTAGAGAATGAGACAGAGATCAGTGA
GTCTGGCATGACAGTGAGAAGTACTGGCTCTGCAACTTCCTTGGCTAGCCAGGGAGAGAGAAGGAGACGAACTCTTCCCCAGCTTCCAAA
TGAAGAAAAGTCTCTTGAGAGCCACAGAGCAAAGGTTGTAACACAGAGGTCAGAGATAGGAGAAAAACAAGACACAGAACTTCAGGAGAA
AGAAACACCTACACAGGTATACCAGAAAGATAAACAAGATGCTGACAGACCCTTGAGTAAAATGAACAGGGCAGTAAATGGAGAGACTCT
CAAAACTGGTGGAGATAATAAAACCCTACTTCACTTAGGCAGCTCTGCTCCTGGAAAAGAGAAAAGTGAAACTGATAAGGAAACTTCTTT
GGTAAAGCAAACATTAGCAAAACTTCAACAACAAGAACAAAGGGAGGAGGCTCAGTGGACACCTACTAAATTGTCTTCCAAAAATGTTTC
AGGTCAGACAGATAAATGTAGGGAGGAAACTTTTAAACAAGAATCACAACCTCCAGAAAAAAATTCAGGACATTCTACAAGCAAAGGAGA
CAGAGTGGCACAAAGTGAGAGCAAGAGAAGAAAAGCTGAGGAAATTCTGAAAAGTCAGACTCCAAAGGGAGGAGACAAGAAGGAATCCTC
CAAGTCATTAGTGCGACAAGGGAGCTTCACTATAGAAAAACCCAGCCCAAACATACCCATAGAACTTATTCCCCATATAAATAAACAGAC
TTCCTCTACTCCTTCTTCTTTAGCATTAACATCTGCAAGTAGAATACGAGAAAGAAGTGAGTCTTTGGATCCTGATTCTAGTATGGACAC
AACCCTTATTCTAAAAGACACAGAAGCAGTAATGGCTTTTCTAGAAGCTAAACTACGTGAAGATAATAAAACTGATGAAGGACCAGATAC
TCCCAGTTATAATAGAGACAATTCTATTTCACCAGAATCTGATGTAGATACAGCTAGTACAATCAGTCTGGTTACTGGAGAAACTGAAAG
AAAGTCAACCCAAAAGCGAAAGAGTTTCACTAGCCTCTATAAAGATAGGTGTTCCACAGGTTCTCCTTCCAAAGATGTTACAAAATCATC
ATCTTCAGGTGCTAGGGAAAAAATGGAAAAGAAAACAAAAAGTCGTTCCACAGATGTGGGTTCAAGAGCAGATGGTCGTAAATTTGTTCA
GTCCAGTGGGAGAATAAGACAGCCCTCAGTAGACTTAACAGATGATGACCAAACCTCTAGTGTACCTCATTCTGCCATCTCTGATATTAT
GTCATCTGATCAAGAAACTTACTCTTGTAAACCTCATGGACGGACTCCACTTACCTCAGCTGATGAGCATGTACATTCCAAACTGGAAGG
AAGTAAAGTAACGAAATCTAAGACTTCTCCGGTGGTATCTGGTTCATCTAGTAAATCAACCACCCTTCCAAGGCCACGACCTACCAGGAC
TTCCCTCTTGCGCAGAGCACGACTTGGTGAAGCTTCAGACAGTGAACTTGCTGATGCTGACAAAGCATCTGTTGCTTCTGAAGTATCCAC
AACAAGTTCTACATCAAAACCTCCCACAGGAAGGCGTAACATCTCTCGGATTGATTTATTGGCTCAGCCTCGTAGAACACGACTTGGCTC
ACTGTCAGCTCGTAGTGACTCTGAAGCAACAATTTCTAGAAGTAGTGCCTCTTCGAGGACCGCAGAAGCCATCATTAGAAGTGGAGCCAG
ACTAGTACCATCAGATAAATTTTCTCCTAGAATTAGAGCTAACAGTATCTCTCGACTCTCAGACTCCAAGGTCAAAAGTATGACCTCAGC
TCATGGCTCTGCTTCAGTAAATTCAAGATGGAGGCGCTTTCCTACTGATTATGCTTCCACCTCAGAAGATGAATTTGGATCAAACCGTAA
TTCCCCTAAACATACCCGTCTACGTACTTCTCCAGCCCTGAAAACCACTCGCTTGCAGAGCGCTGGATCAGCAATGCCTACTAGTTCTTC
ATTCAAACACCGGATTAAAGAGCAGGAAGACTACATCCGAGATTGGACTGCTCATCGAGAAGAGATAGCCAGGATCAGCCAAGATCTTGC
TCTCATTGCTCGGGAGATCAACGATGTAGCAGGAGAGATAGATTCAGTGACTTCATCAGGCACTGCCCCTAGTACCACAGTAAGCACTGC
TGCCACCACCCCTGGCTCTGCCATAGACACTAGAGAAGAGTTGGTTGATCGTGTTTTTGATGAAAGCCTCAACTTCCGAAAGATTCCTCC
ATTAGTTCATTCCAAAACACCAGAAGGAAACAACGGTCGATCTGGTGATCCAAGACCTCAAGCAGCAGAGCCTCCCGATCACTTAACAAT
TACAAGGCGGAGAACCTGGAGCAGGGATGAAGTCATGGGAGATAATCTGCTGCTGTCATCCGTCTTTCAGTTCTCTAAGAAGATAAGACA
ATCTATAGATAAGACAGCTGGAAAGATCAGAATATTATTTAAAGACAAAGATCGGAATTGGGATGACATAGAAAGCAAATTAAGAGCCGA
AAGTGAAGTCCCTATTGTGAAAACCTCAAGCATGGAGATTTCTTCTATCTTACAGGAACTGAAAAGAGTAGAAAAGCAGCTGCAAGCAAT
CAATGCTATGATTGATCCTGATGGAACTTTGGAGGCTCTGAACAACATGGGATTTCCCAGTGCTATGTTGCCATCTCCACCGAAACAGAA
GTCCAGCCCTGTGAATAACCACCACAGCCCGGGTCAGACACCAACACTTGGCCAACCAGAAGCTAGGGCTCTTCATCCTGCTGCTGTTTC
AGCCGCAGCTGAATTTGAGAATGCTGAATCTGAGGCTGATTTCAGTATACATTTCAATAGATTCAACCCCGATGGGGAAGAGGAAGATGT
TACAGTACAAGAATGACTTTCTCTTGATTGTTGAAAAATCATTACCTGTGGAATGGCTAGGAATATTGGAAGCAGCATAGTGTTGATGTA
CGCAAAACAAGACAGCTTGGTCAGCTACAATCTTGGAATCCCTGTCTTCTTAATTTTATTTATTTATTTTTGACGTATAATGTAGTATAT
CAATCCTTTCAAACTATTTAGATAACCACTTGATGCACAAATAGGAAAAAGCAGATTGTGGCAGTGTCGCCTTTTGTGGTTTTATGATTT
TCAAATTGAATTTAATGATTACACCCTTTCCCTTCATAGATCTTTTTTCTTTTTTTTAAGCCATGCTGTGACCTACAAGCAAACTAAATA
GCCAACATTTCTGAACCCCTAAGTCTCCTGTGCCAAGCTGCTCCCTGAAATGGACTTCTTCATCTGTACAGATTTGTTAAACCATTCTAT
TTGCTTCTTAATAATAGGATTTATATTAGTACTCATTACCATTGGACACAATGACATAAGTACTCTCCACAGTAAAGCAGACCTTTCACA
ACAGTCACTCTGTGTCCTAAAATTTTCCAACATAGATGTGATTTATATAACTTTGTTGATACGTAAATTGTCTTGGGGTTTACGGAAATT
AACTATTATGTTTGCACTAAGATTTGCTGGGAGTGGTAGGTGGACATATCTATATATCAATAAGGACTAACCGTCTTTTTTGTACATAGG
AGATTGATAATACTGTATTTGTTTTAAGCCCACAGTGTTTTACTCCACTTTCAAAAAGATCAATTTGGCACTTTTTTTCATTTTTTTTAA
TGGAAATAAGATTTGGTCTCTCATTTTAGGTTAAATGATAACTAGAAAGATTAAACTAGACAGATAGTTTAGGTGGAGTATATTTTTAAA
ACTCAGAACATGTATATTGGTCCTGTGTTACCAAGTTTATATGTGACAGTTGAAAAAGAAATTCCCTTGAAATGATCATGAGGTTAAAAT
TTTCTTCATTAGGGGACTTGGAGAACCAGTAGTCGTAAGATTAGTTGATAGTTTCACTCCCAAGCAATGAATTGCTTCTGTGTGTTTCCC
TGTAGGACTCAATAGTAAATGCTGTCTGTCTTACACATTTATAAGGACCCTGCAAGACGACGACAAAGGCCTTTGGCCTGTGCTACTAAA
CAAGAAGCCTATGAAAAATTTCTTCTTTAAACTTGTTTTTTCTCTTTCCAGTAAGTTCACATTTGGATAATTTTAAAAAGAAAAGTAATT
ACCTTTGTGTTTCCAGAACACTATAATTGGGGTGTATCTTAATTCAGTTAAATATTATTAGTAGACCTGGATTTTCCCCCTTGACCCCAT
CAGTCTATAAAGGTTAAACTGCAACTTTTATGAAATGGTCTTTAATATTTCCACAATAATCCTGTGCTATATTTGTTTTAAGAAACAAAG
TAACTCTATACACTTCAAGACTTTACAGGATTTTTTAAATCCTGTATTGTTGGATCAATTAATAAAGATGCAAAAAAACTTTATAGAGAT
GTAAAAACAAAACTATAATGGATCTCCTATTTTTCTTTAAATACAAAAAAAAAAAGGTAAATGAACTATTCTCCTTGTAAAGCTAAATTC
CCCATTCTGTCTAATAAAGGAAGACTGAAAAAAGGTTTTAAAGAACATAAATGGAAAGATACAAATGCTTTGAAGGAATAAACGAAATGT
TAAAACAGGGTCAATCCATTTGAAGAAAAAGTTGGACAAAATAATCAGCATTGCTCCCTCTTTTATTTAATATTTGGGTACTGATTATAT
CCACATGGAAGTAGAAGGTAAGGAGTTTAGGAAAATACTAGAATCTACTCTGCTTACATTCTTGTTTAAGTGTTTACACAGTTTGGTTCA
ATTATAAACATTTGGCCTTTTACTATGTTATTTTTATTTTGTATGAATACATTATCCTCCTTATTTATTTTTGTTACATTTATTACTTAT

>3497_3497_9_AKT3-CEP170_AKT3_chr1_244006427_ENST00000366539_CEP170_chr1_243336148_ENST00000366544_length(amino acids)=1028AA_BP=
MEERKPLTTSGFHHSEEGTSSSGSKRWVSQWASLAANHTRHDQEERIMEFSAPLPLENETEISESGMTVRSTGSATSLASQGERRRRTLP
QLPNEEKSLESHRAKVVTQRSEIGEKQDTELQEKETPTQVYQKDKQDADRPLSKMNRAVNGETLKTGGDNKTLLHLGSSAPGKEKSETDK
ETSLVKQTLAKLQQQEQREEAQWTPTKLSSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDRVAQSESKRRKAEEILKSQTPKGGDK
KESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSSLALTSASRIRERSESLDPDSSMDTTLILKDTEAVMAFLEAKLREDNKTDE
GPDTPSYNRDNSISPESDVDTASTISLVTGETERKSTQKRKSFTSLYKDRCSTGSPSKDVTKSSSSGAREKMEKKTKSRSTDVGSRADGR
KFVQSSGRIRQPSVDLTDDDQTSSVPHSAISDIMSSDQETYSCKPHGRTPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPR
PTRTSLLRRARLGEASDSELADADKASVASEVSTTSSTSKPPTGRRNISRIDLLAQPRRTRLGSLSARSDSEATISRSSASSRTAEAIIR
SGARLVPSDKFSPRIRANSISRLSDSKVKSMTSAHGSASVNSRWRRFPTDYASTSEDEFGSNRNSPKHTRLRTSPALKTTRLQSAGSAMP
TSSSFKHRIKEQEDYIRDWTAHREEIARISQDLALIAREINDVAGEIDSVTSSGTAPSTTVSTAATTPGSAIDTREELVDRVFDESLNFR
KIPPLVHSKTPEGNNGRSGDPRPQAAEPPDHLTITRRRTWSRDEVMGDNLLLSSVFQFSKKIRQSIDKTAGKIRILFKDKDRNWDDIESK
LRAESEVPIVKTSSMEISSILQELKRVEKQLQAINAMIDPDGTLEALNNMGFPSAMLPSPPKQKSSPVNNHHSPGQTPTLGQPEARALHP

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Fusion Gene PPI Analysis for AKT3-CEP170


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCEP170chr1:244006427chr1:243336148ENST000003665429201015_1460522.01585.0CCDC61
TgeneCEP170chr1:244006427chr1:243336148ENST000003665438191015_1460424.01461.0CCDC61
TgeneCEP170chr1:244006427chr1:243336148ENST000003665448191015_1460424.01487.0CCDC61


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AKT3-CEP170


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AKT3-CEP170


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAKT3C4014738MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 24GENOMICS_ENGLAND;UNIPROT
HgeneAKT3C4012727MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 12GENOMICS_ENGLAND
HgeneAKT3C0152427Polydactyly1GENOMICS_ENGLAND
HgeneAKT3C0431380Cortical Dysplasia1CTD_human
HgeneAKT3C0431391Hemimegalencephaly1ORPHANET
HgeneAKT3C1863924Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome1CTD_human;ORPHANET
HgeneAKT3C1955869Malformations of Cortical Development1CTD_human