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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MIR3615-SLC9A3R1 (FusionGDB2 ID:HG100500847TG9368)

Fusion Gene Summary for MIR3615-SLC9A3R1

check button Fusion gene summary
Fusion gene informationFusion gene name: MIR3615-SLC9A3R1
Fusion gene ID: hg100500847tg9368
HgeneTgene
Gene symbol

MIR3615

SLC9A3R1

Gene ID

100500847

9368

Gene namemicroRNA 3615SLC9A3 regulator 1
Synonymsmir-3615EBP50|NHERF|NHERF-1|NHERF1|NPHLOP2
Cytomap('MIR3615')('SLC9A3R1')

17q25.1

17q25.1

Type of genencRNAprotein-coding
Descriptionhsa-mir-3615Na(+)/H(+) exchange regulatory cofactor NHE-RF1Na+/H+ exchange regulatory co-factorezrin-radixin-moesin binding phosphoprotein-50regulatory cofactor of Na(+)/H(+) exchangersolute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory facto
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000581999, ENST00000585285, 
Fusion gene scores* DoF score1 X 6 X 1=69 X 12 X 6=648
# samples 313
** MAII scorelog2(3/6*10)=2.32192809488736log2(13/648*10)=-2.31748218985617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MIR3615 [Title/Abstract] AND SLC9A3R1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMIR3615(72744775)-SLC9A3R1(72745291), # samples:4
MIR3615(72744768)-SLC9A3R1(72745298), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLC9A3R1

GO:0008285

negative regulation of cell proliferation

20012548

TgeneSLC9A3R1

GO:0070373

negative regulation of ERK1 and ERK2 cascade

20012548

TgeneSLC9A3R1

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

20012548



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-BR-6564-11AMIR3615chr17

72744768

-SLC9A3R1chr17

72745298

+
ChimerDB4Non-CancerTCGA-BR-6564-11AMIR3615chr17

72744772

-SLC9A3R1chr17

72745075

+
ChimerDB4Non-CancerTCGA-BR-6564-11AMIR3615chr17

72744775

-SLC9A3R1chr17

72745291

+
ChimerDB4Non-CancerTCGA-BR-7851-11AMIR3615chr17

72744768

-SLC9A3R1chr17

72745298

+
ChimerDB4Non-CancerTCGA-BR-7851-11AMIR3615chr17

72744775

-SLC9A3R1chr17

72745291

+
ChimerDB4Non-CancerTCGA-IN-8462-11AMIR3615chr17

72744768

-SLC9A3R1chr17

72745298

+
ChimerDB4Non-CancerTCGA-IN-8462-11AMIR3615chr17

72744770

-SLC9A3R1chr17

72745062

+
ChimerDB4Non-CancerTCGA-IN-8462-11AMIR3615chr17

72744771

-SLC9A3R1chr17

72758157

+
ChimerDB4Non-CancerTCGA-IN-8462-11AMIR3615chr17

72744775

-SLC9A3R1chr17

72745291

+
ChimerDB4Non-CancerTCGA-IN-8462-11AMIR3615chr17

72744778

-SLC9A3R1chr17

72758150

+
ChimerDB4Non-CancerTCGA-IP-7968-11AMIR3615chr17

72744768

-SLC9A3R1chr17

72745298

+
ChimerDB4Non-CancerTCGA-IP-7968-11AMIR3615chr17

72744775

-SLC9A3R1chr17

72745291

+
ChimerDB4Non-CancerTCGA-IP-7968-11AMIR3615chr17

72744778

-SLC9A3R1chr17

72758150

+


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Fusion Gene ORF analysis for MIR3615-SLC9A3R1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000581999ENST00000262613MIR3615chr17

72744772

-SLC9A3R1chr17

72745075

+
3UTR-3CDSENST00000581999ENST00000262613MIR3615chr17

72744768

-SLC9A3R1chr17

72745298

+
3UTR-3CDSENST00000581999ENST00000262613MIR3615chr17

72744775

-SLC9A3R1chr17

72745291

+
3UTR-3CDSENST00000581999ENST00000262613MIR3615chr17

72744770

-SLC9A3R1chr17

72745062

+
3UTR-3CDSENST00000581999ENST00000262613MIR3615chr17

72744771

-SLC9A3R1chr17

72758157

+
3UTR-3CDSENST00000581999ENST00000262613MIR3615chr17

72744778

-SLC9A3R1chr17

72758150

+
3UTR-5UTRENST00000581999ENST00000413388MIR3615chr17

72744771

-SLC9A3R1chr17

72758157

+
3UTR-5UTRENST00000581999ENST00000413388MIR3615chr17

72744778

-SLC9A3R1chr17

72758150

+
3UTR-intronENST00000581999ENST00000413388MIR3615chr17

72744772

-SLC9A3R1chr17

72745075

+
3UTR-intronENST00000581999ENST00000413388MIR3615chr17

72744768

-SLC9A3R1chr17

72745298

+
3UTR-intronENST00000581999ENST00000413388MIR3615chr17

72744775

-SLC9A3R1chr17

72745291

+
3UTR-intronENST00000581999ENST00000413388MIR3615chr17

72744770

-SLC9A3R1chr17

72745062

+
intron-3CDSENST00000585285ENST00000262613MIR3615chr17

72744772

-SLC9A3R1chr17

72745075

+
intron-3CDSENST00000585285ENST00000262613MIR3615chr17

72744768

-SLC9A3R1chr17

72745298

+
intron-3CDSENST00000585285ENST00000262613MIR3615chr17

72744775

-SLC9A3R1chr17

72745291

+
intron-3CDSENST00000585285ENST00000262613MIR3615chr17

72744770

-SLC9A3R1chr17

72745062

+
intron-3CDSENST00000585285ENST00000262613MIR3615chr17

72744771

-SLC9A3R1chr17

72758157

+
intron-3CDSENST00000585285ENST00000262613MIR3615chr17

72744778

-SLC9A3R1chr17

72758150

+
intron-5UTRENST00000585285ENST00000413388MIR3615chr17

72744771

-SLC9A3R1chr17

72758157

+
intron-5UTRENST00000585285ENST00000413388MIR3615chr17

72744778

-SLC9A3R1chr17

72758150

+
intron-intronENST00000585285ENST00000413388MIR3615chr17

72744772

-SLC9A3R1chr17

72745075

+
intron-intronENST00000585285ENST00000413388MIR3615chr17

72744768

-SLC9A3R1chr17

72745298

+
intron-intronENST00000585285ENST00000413388MIR3615chr17

72744775

-SLC9A3R1chr17

72745291

+
intron-intronENST00000585285ENST00000413388MIR3615chr17

72744770

-SLC9A3R1chr17

72745062

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MIR3615-SLC9A3R1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for MIR3615-SLC9A3R1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:72744775/:72745291)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MIR3615-SLC9A3R1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MIR3615-SLC9A3R1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MIR3615-SLC9A3R1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MIR3615-SLC9A3R1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMIR3615C0019193Hepatitis, Toxic1CTD_human
HgeneMIR3615C0023891Liver Cirrhosis, Alcoholic1CTD_human
HgeneMIR3615C0860207Drug-Induced Liver Disease1CTD_human
HgeneMIR3615C1262760Hepatitis, Drug-Induced1CTD_human
HgeneMIR3615C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneMIR3615C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneMIR3615C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneC2676782Nephrolithiasis-Osteoporosis, Hypophosphatemic, 23CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0021367Mammary Ductal Carcinoma1CTD_human
TgeneC1134719Invasive Ductal Breast Carcinoma1CTD_human