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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABCC5-TGFBI (FusionGDB2 ID:HG10057TG7045)

Fusion Gene Summary for ABCC5-TGFBI

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCC5-TGFBI
Fusion gene ID: hg10057tg7045
HgeneTgene
Gene symbol

ABCC5

TGFBI

Gene ID

10057

7045

Gene nameATP binding cassette subfamily C member 5transforming growth factor beta induced
SynonymsABC33|EST277145|MOAT-C|MOATC|MRP5|SMRP|pABC11BIGH3|CDB1|CDG2|CDGG1|CSD|CSD1|CSD2|CSD3|EBMD|LCD1
Cytomap('ABCC5')('TGFBI')

3q27.1

5q31.1

Type of geneprotein-codingprotein-coding
Descriptionmultidrug resistance-associated protein 5ATP-binding cassette, sub-family C (CFTR/MRP), member 5canalicular multispecific organic anion transporter Cmulti-specific organic anion transporter Ctransforming growth factor-beta-induced protein ig-h3RGD-CAPRGD-containing collagen-associated proteinbeta ig-h3betaig-h3kerato-epithelintransforming growth factor beta-induced 68kDatransforming growth factor, beta-induced, 68kD
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000265586, ENST00000334444, 
ENST00000382494, ENST00000392579, 
ENST00000427120, ENST00000446941, 
ENST00000492216, 
Fusion gene scores* DoF score16 X 12 X 9=17288 X 9 X 2=144
# samples 159
** MAII scorelog2(15/1728*10)=-3.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/144*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABCC5 [Title/Abstract] AND TGFBI [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABCC5(183705558)-TGFBI(135397183), # samples:1
Anticipated loss of major functional domain due to fusion event.ABCC5-TGFBI seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC5-TGFBI seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC5-TGFBI seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC5-TGFBI seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC5-TGFBI seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ABCC5-TGFBI seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ABCC5-TGFBI seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCC5

GO:0042908

xenobiotic transport

10840050

HgeneABCC5

GO:0140115

export across plasma membrane

10840050


check buttonFusion gene breakpoints across ABCC5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TGFBI (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for ABCC5-TGFBI

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000382494ENST00000442011ABCC5chr3183705558-TGFBIchr5135397183+0.209829970.7901701
ENST00000382494ENST00000305126ABCC5chr3183705558-TGFBIchr5135397183+0.21708260.78291744
ENST00000382494ENST00000508076ABCC5chr3183705558-TGFBIchr5135397183+0.209734890.7902651

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Fusion Genomic Features for ABCC5-TGFBI


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ABCC5chr3183705557-TGFBIchr5135397188+0.0010721350.9989279
ABCC5chr3183705557-TGFBIchr5135397188+0.0010721350.9989279

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ABCC5-TGFBI


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:183705558/chr5:135397183)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC5chr3:183705558chr5:135397183ENST00000334444-530179_1991971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000382494-57179_199197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000392579-56179_199197226.0TransmembraneHelical
TgeneTGFBIchr3:183705558chr5:135397183ENST000004420111317642_644635684.0MotifCell attachment site

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC5chr3:183705558chr5:135397183ENST00000334444-5301193_14271971438.0DomainABC transporter 2
HgeneABCC5chr3:183705558chr5:135397183ENST00000334444-530179_4591971438.0DomainABC transmembrane type-1 1
HgeneABCC5chr3:183705558chr5:135397183ENST00000334444-530562_7831971438.0DomainABC transporter 1
HgeneABCC5chr3:183705558chr5:135397183ENST00000334444-530859_11551971438.0DomainABC transmembrane type-1 2
HgeneABCC5chr3:183705558chr5:135397183ENST00000382494-571193_1427197533.3333333333334DomainABC transporter 2
HgeneABCC5chr3:183705558chr5:135397183ENST00000382494-57179_459197533.3333333333334DomainABC transmembrane type-1 1
HgeneABCC5chr3:183705558chr5:135397183ENST00000382494-57562_783197533.3333333333334DomainABC transporter 1
HgeneABCC5chr3:183705558chr5:135397183ENST00000382494-57859_1155197533.3333333333334DomainABC transmembrane type-1 2
HgeneABCC5chr3:183705558chr5:135397183ENST00000392579-561193_1427197226.0DomainABC transporter 2
HgeneABCC5chr3:183705558chr5:135397183ENST00000392579-56179_459197226.0DomainABC transmembrane type-1 1
HgeneABCC5chr3:183705558chr5:135397183ENST00000392579-56562_783197226.0DomainABC transporter 1
HgeneABCC5chr3:183705558chr5:135397183ENST00000392579-56859_1155197226.0DomainABC transmembrane type-1 2
HgeneABCC5chr3:183705558chr5:135397183ENST00000334444-5301227_12341971438.0Nucleotide bindingATP 2
HgeneABCC5chr3:183705558chr5:135397183ENST00000334444-530595_6021971438.0Nucleotide bindingATP 1
HgeneABCC5chr3:183705558chr5:135397183ENST00000382494-571227_1234197533.3333333333334Nucleotide bindingATP 2
HgeneABCC5chr3:183705558chr5:135397183ENST00000382494-57595_602197533.3333333333334Nucleotide bindingATP 1
HgeneABCC5chr3:183705558chr5:135397183ENST00000392579-561227_1234197226.0Nucleotide bindingATP 2
HgeneABCC5chr3:183705558chr5:135397183ENST00000392579-56595_602197226.0Nucleotide bindingATP 1
HgeneABCC5chr3:183705558chr5:135397183ENST00000334444-5301018_10381971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000334444-5301104_11241971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000334444-5301127_11471971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000334444-530219_2391971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000334444-530296_3161971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000334444-530317_3371971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000334444-530400_4201971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000334444-530434_4541971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000334444-530608_6281971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000334444-530848_8681971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000334444-530917_9371971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000334444-530997_10171971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000382494-571018_1038197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000382494-571104_1124197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000382494-571127_1147197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000382494-57219_239197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000382494-57296_316197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000382494-57317_337197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000382494-57400_420197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000382494-57434_454197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000382494-57608_628197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000382494-57848_868197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000382494-57917_937197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000382494-57997_1017197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000392579-561018_1038197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000392579-561104_1124197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000392579-561127_1147197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000392579-56219_239197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000392579-56296_316197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000392579-56317_337197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000392579-56400_420197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000392579-56434_454197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000392579-56608_628197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000392579-56848_868197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000392579-56917_937197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr5:135397183ENST00000392579-56997_1017197226.0TransmembraneHelical
TgeneTGFBIchr3:183705558chr5:135397183ENST000004420111317103_236635684.0DomainFAS1 1
TgeneTGFBIchr3:183705558chr5:135397183ENST000004420111317240_371635684.0DomainFAS1 2
TgeneTGFBIchr3:183705558chr5:135397183ENST000004420111317375_498635684.0DomainFAS1 3
TgeneTGFBIchr3:183705558chr5:135397183ENST00000442011131745_99635684.0DomainEMI
TgeneTGFBIchr3:183705558chr5:135397183ENST000004420111317502_632635684.0DomainFAS1 4


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Fusion Gene Sequence for ABCC5-TGFBI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>309_309_1_ABCC5-TGFBI_ABCC5_chr3_183705558_ENST00000382494_TGFBI_chr5_135397183_ENST00000305126_length(transcript)=1441nt_BP=706nt
GGCTCATGCTCGGGAGCGTGGTTGAGCGGCTGGCGCGGTTGTCCTGGAGCAGGGGCGCAGGAATTCTGATGTGAAACTAACAGTCTGTGA
GCCCTGGAACCTCCACTCAGAGAAGATGAAGGATATCGACATAGGAAAAGAGTATATCATCCCCAGTCCTGGGTATAGAAGTGTGAGGGA
GAGAACCAGCACTTCTGGGACGCACAGAGACCGTGAAGATTCCAAGTTCAGGAGAACTCGACCGTTGGAATGCCAAGATGCCTTGGAAAC
AGCAGCCCGAGCCGAGGGCCTCTCTCTTGATGCCTCCATGCATTCTCAGCTCAGAATCCTGGATGAGGAGCATCCCAAGGGAAAGTACCA
TCATGGCTTGAGTGCTCTGAAGCCCATCCGGACTACTTCCAAACACCAGCACCCAGTGGACAATGCTGGGCTTTTTTCCTGTATGACTTT
TTCGTGGCTTTCTTCTCTGGCCCGTGTGGCCCACAAGAAGGGGGAGCTCTCAATGGAAGACGTGTGGTCTCTGTCCAAGCACGAGTCTTC
TGACGTGAACTGCAGAAGACTAGAGAGACTGTGGCAAGAAGAGCTGAATGAAGTTGGGCCAGACGCTGCTTCCCTGCGAAGGGTTGTGTG
GATCTTCTGCCGCACCAGGCTCATCCTGTCCATCGTGTGCCTGATGATCACGCAGCTGGCTGGCTTCAGTGGACCACCAACAGACCTCAG
GAAAGAGGGGATGAACTTGCAGACTCTGCGCTTGAGATCTTCAAACAAGCATCAGCGTTTTCCAGGCCTGAGCAGCCTCAGGTCCTCTGT
TCCCCTGTCTATCAAAAGTTATTAGAGAGGATGAAGCATTAGCTTGAAGCACTACAGGAGGAATGCACCACGGCAGCTCTCCGCCAATTT
CTCTCAGATTTCCACAGAGACTGTTTGAATGTTTTCAAAACCAAGTATCACACTTTAATGTACATGGGCCGCACCATAATGAGATGTGAG
CCTTGTGCATGTGGGGGAGGAGGGAGAGAGATGTACTTTTTAAATCATGTTCCCCCTAAACATGGCTGTTAACCCACTGCATGCAGAAAC
TTGGATGTCACTGCCTGACATTCACTTCCAGAGAGGACCTATCCCAAATGTGGAATTGACTGCCTATGCCAAGTCCCTGGAAAAGGAGCT
TCAGTATTGTGGGGCTCATAAAACATGAATCAAGCAATCCAGCCTCATGGGAAGTCCTGGCACAGTTTTTGTAAAGCCCTTGCACAGCTG
GAGAAATGGCATCATTATAAGCTATGAGTTGAAATGTTCTGTCAAATGTGTCTCACATCTACACGTGGCTTGGAGGCTTTTATGGGGCCC
TGTCCAGGTAGAAAAGAAATGGTATGTAGAGCTTAGATTTCCCTATTGTGACAGAGCCATGGTGTGTTTGTAATAATAAAACCAAAGAAA
C

>309_309_1_ABCC5-TGFBI_ABCC5_chr3_183705558_ENST00000382494_TGFBI_chr5_135397183_ENST00000305126_length(amino acids)=263AA_BP=221
MEQGRRNSDVKLTVCEPWNLHSEKMKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLSLDASMH
SQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEE
LNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPPTDLRKEGMNLQTLRLRSSNKHQRFPGLSSLRSSVPLSIKSY

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>309_309_2_ABCC5-TGFBI_ABCC5_chr3_183705558_ENST00000382494_TGFBI_chr5_135397183_ENST00000442011_length(transcript)=1443nt_BP=706nt
GGCTCATGCTCGGGAGCGTGGTTGAGCGGCTGGCGCGGTTGTCCTGGAGCAGGGGCGCAGGAATTCTGATGTGAAACTAACAGTCTGTGA
GCCCTGGAACCTCCACTCAGAGAAGATGAAGGATATCGACATAGGAAAAGAGTATATCATCCCCAGTCCTGGGTATAGAAGTGTGAGGGA
GAGAACCAGCACTTCTGGGACGCACAGAGACCGTGAAGATTCCAAGTTCAGGAGAACTCGACCGTTGGAATGCCAAGATGCCTTGGAAAC
AGCAGCCCGAGCCGAGGGCCTCTCTCTTGATGCCTCCATGCATTCTCAGCTCAGAATCCTGGATGAGGAGCATCCCAAGGGAAAGTACCA
TCATGGCTTGAGTGCTCTGAAGCCCATCCGGACTACTTCCAAACACCAGCACCCAGTGGACAATGCTGGGCTTTTTTCCTGTATGACTTT
TTCGTGGCTTTCTTCTCTGGCCCGTGTGGCCCACAAGAAGGGGGAGCTCTCAATGGAAGACGTGTGGTCTCTGTCCAAGCACGAGTCTTC
TGACGTGAACTGCAGAAGACTAGAGAGACTGTGGCAAGAAGAGCTGAATGAAGTTGGGCCAGACGCTGCTTCCCTGCGAAGGGTTGTGTG
GATCTTCTGCCGCACCAGGCTCATCCTGTCCATCGTGTGCCTGATGATCACGCAGCTGGCTGGCTTCAGTGGACCACCAACAGACCTCAG
GAAAGAGGGGATGAACTTGCAGACTCTGCGCTTGAGATCTTCAAACAAGCATCAGCGTTTTCCAGGGCTTCCCAGAGGTCTGTGCGACTA
GCCCCTGTCTATCAAAAGTTATTAGAGAGGATGAAGCATTAGCTTGAAGCACTACAGGAGGAATGCACCACGGCAGCTCTCCGCCAATTT
CTCTCAGATTTCCACAGAGACTGTTTGAATGTTTTCAAAACCAAGTATCACACTTTAATGTACATGGGCCGCACCATAATGAGATGTGAG
CCTTGTGCATGTGGGGGAGGAGGGAGAGAGATGTACTTTTTAAATCATGTTCCCCCTAAACATGGCTGTTAACCCACTGCATGCAGAAAC
TTGGATGTCACTGCCTGACATTCACTTCCAGAGAGGACCTATCCCAAATGTGGAATTGACTGCCTATGCCAAGTCCCTGGAAAAGGAGCT
TCAGTATTGTGGGGCTCATAAAACATGAATCAAGCAATCCAGCCTCATGGGAAGTCCTGGCACAGTTTTTGTAAAGCCCTTGCACAGCTG
GAGAAATGGCATCATTATAAGCTATGAGTTGAAATGTTCTGTCAAATGTGTCTCACATCTACACGTGGCTTGGAGGCTTTTATGGGGCCC
TGTCCAGGTAGAAAAGAAATGGTATGTAGAGCTTAGATTTCCCTATTGTGACAGAGCCATGGTGTGTTTGTAATAATAAAACCAAAGAAA
CAT

>309_309_2_ABCC5-TGFBI_ABCC5_chr3_183705558_ENST00000382494_TGFBI_chr5_135397183_ENST00000442011_length(amino acids)=255AA_BP=221
MEQGRRNSDVKLTVCEPWNLHSEKMKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLSLDASMH
SQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEE
LNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPPTDLRKEGMNLQTLRLRSSNKHQRFPGLPRGLCD

--------------------------------------------------------------
>309_309_3_ABCC5-TGFBI_ABCC5_chr3_183705558_ENST00000382494_TGFBI_chr5_135397183_ENST00000508076_length(transcript)=1441nt_BP=706nt
GGCTCATGCTCGGGAGCGTGGTTGAGCGGCTGGCGCGGTTGTCCTGGAGCAGGGGCGCAGGAATTCTGATGTGAAACTAACAGTCTGTGA
GCCCTGGAACCTCCACTCAGAGAAGATGAAGGATATCGACATAGGAAAAGAGTATATCATCCCCAGTCCTGGGTATAGAAGTGTGAGGGA
GAGAACCAGCACTTCTGGGACGCACAGAGACCGTGAAGATTCCAAGTTCAGGAGAACTCGACCGTTGGAATGCCAAGATGCCTTGGAAAC
AGCAGCCCGAGCCGAGGGCCTCTCTCTTGATGCCTCCATGCATTCTCAGCTCAGAATCCTGGATGAGGAGCATCCCAAGGGAAAGTACCA
TCATGGCTTGAGTGCTCTGAAGCCCATCCGGACTACTTCCAAACACCAGCACCCAGTGGACAATGCTGGGCTTTTTTCCTGTATGACTTT
TTCGTGGCTTTCTTCTCTGGCCCGTGTGGCCCACAAGAAGGGGGAGCTCTCAATGGAAGACGTGTGGTCTCTGTCCAAGCACGAGTCTTC
TGACGTGAACTGCAGAAGACTAGAGAGACTGTGGCAAGAAGAGCTGAATGAAGTTGGGCCAGACGCTGCTTCCCTGCGAAGGGTTGTGTG
GATCTTCTGCCGCACCAGGCTCATCCTGTCCATCGTGTGCCTGATGATCACGCAGCTGGCTGGCTTCAGTGGACCACCAACAGACCTCAG
GAAAGAGGGGATGAACTTGCAGACTCTGCGCTTGAGATCTTCAAACAAGCATCAGCGTTTTCCAGGGCTTCCCAGAGGTCTGTGCGACTA
GCCCCTGTCTATCAAAAGTTATTAGAGAGGATGAAGCATTAGCTTGAAGCACTACAGGAGGAATGCACCACGGCAGCTCTCCGCCAATTT
CTCTCAGATTTCCACAGAGACTGTTTGAATGTTTTCAAAACCAAGTATCACACTTTAATGTACATGGGCCGCACCATAATGAGATGTGAG
CCTTGTGCATGTGGGGGAGGAGGGAGAGAGATGTACTTTTTAAATCATGTTCCCCCTAAACATGGCTGTTAACCCACTGCATGCAGAAAC
TTGGATGTCACTGCCTGACATTCACTTCCAGAGAGGACCTATCCCAAATGTGGAATTGACTGCCTATGCCAAGTCCCTGGAAAAGGAGCT
TCAGTATTGTGGGGCTCATAAAACATGAATCAAGCAATCCAGCCTCATGGGAAGTCCTGGCACAGTTTTTGTAAAGCCCTTGCACAGCTG
GAGAAATGGCATCATTATAAGCTATGAGTTGAAATGTTCTGTCAAATGTGTCTCACATCTACACGTGGCTTGGAGGCTTTTATGGGGCCC
TGTCCAGGTAGAAAAGAAATGGTATGTAGAGCTTAGATTTCCCTATTGTGACAGAGCCATGGTGTGTTTGTAATAATAAAACCAAAGAAA
C

>309_309_3_ABCC5-TGFBI_ABCC5_chr3_183705558_ENST00000382494_TGFBI_chr5_135397183_ENST00000508076_length(amino acids)=255AA_BP=221
MEQGRRNSDVKLTVCEPWNLHSEKMKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLSLDASMH
SQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEE
LNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPPTDLRKEGMNLQTLRLRSSNKHQRFPGLPRGLCD

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Fusion Gene PPI Analysis for ABCC5-TGFBI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABCC5-TGFBI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABCC5-TGFBI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCC5C0003873Rheumatoid Arthritis1CTD_human
HgeneABCC5C0009402Colorectal Carcinoma1CTD_human
HgeneABCC5C0009404Colorectal Neoplasms1CTD_human
HgeneABCC5C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC1690006Lattice corneal dystrophy Type I12CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0339278Reis-Bucklers' corneal dystrophy6CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC1641846Groenouw corneal dystrophy type I (disorder)4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC1837974Corneal Dystrophy, Lattice Type IIIA4CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0521723Corneal dystrophy, epithelial basement membrane3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC1275685Avellino corneal dystrophy3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC1562894Thiel-Behnke corneal dystrophy3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0000786Spontaneous abortion1CTD_human
TgeneC0000822Abortion, Tubal1CTD_human
TgeneC0011881Diabetic Nephropathy1CTD_human
TgeneC0017667Nodular glomerulosclerosis1CTD_human
TgeneC0034189Pyemia1CTD_human
TgeneC0036690Septicemia1CTD_human
TgeneC0243026Sepsis1CTD_human
TgeneC1719672Severe Sepsis1CTD_human
TgeneC3830362Early Pregnancy Loss1CTD_human
TgeneC4552766Miscarriage1CTD_human