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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:ATP9A-PICALM (FusionGDB2 ID:HG10079TG8301)

Fusion Gene Summary for ATP9A-PICALM

Fusion gene summary

Fusion gene information	Fusion gene name: ATP9A-PICALM
	Fusion gene ID: hg10079tg8301
		Hgene	Tgene
	Gene symbol	ATP9A	PICALM
	Gene ID	10079	8301
	Gene name	ATPase phospholipid transporting 9A (putative)	phosphatidylinositol binding clathrin assembly protein
	Synonyms	ATPIIA	CALM\|CLTH\|LAP
	Cytomap	('ATP9A')('PICALM') 20q13.2	11q14.2
	Type of gene	protein-coding	protein-coding
	Description	probable phospholipid-transporting ATPase IIAATPase type IV, phospholipid-transporting (P-type),(putative)ATPase, class II, type 9Aphospholipid-transporting ATPase IIA	phosphatidylinositol-binding clathrin assembly proteinclathrin assembly lymphoid myeloid leukemia protein
	Modification date	20200313	20200322
	UniProtAcc	.	Q13492
	Ensembl transtripts involved in fusion gene	ENST00000338821, ENST00000311637, ENST00000402822, ENST00000477492,
Fusion gene scores	* DoF score	15 X 13 X 10=1950	35 X 26 X 12=10920
	# samples	16	44
	** MAII score	log2(16/1950*10)=-3.60733031374961 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(44/10920*10)=-4.63332552228256 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ATP9A [Title/Abstract] AND PICALM [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ATP9A(50312631)-PICALM(85742653), # samples:1 ATP9A(50312632)-PICALM(85742653), # samples:1
Anticipated loss of major functional domain due to fusion event.	ATP9A-PICALM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP9A-PICALM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP9A-PICALM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ATP9A-PICALM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PICALM	GO:0006897	endocytosis	22118466
Tgene	PICALM	GO:0006898	receptor-mediated endocytosis	10436022
Tgene	PICALM	GO:0032880	regulation of protein localization	10436022
Tgene	PICALM	GO:0045893	positive regulation of transcription, DNA-templated	11425879
Tgene	PICALM	GO:0048261	negative regulation of receptor-mediated endocytosis	10436022
Tgene	PICALM	GO:1905224	clathrin-coated pit assembly	16262731

Fusion gene breakpoints across ATP9A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PICALM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-27-2526-01A	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
ChimerDB4	GBM	TCGA-27-2526	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-

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Fusion Gene ORF analysis for ATP9A-PICALM

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000338821	ENST00000356360	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
5CDS-5UTR	ENST00000338821	ENST00000356360	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
5CDS-5UTR	ENST00000338821	ENST00000528398	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
5CDS-5UTR	ENST00000338821	ENST00000528398	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
5CDS-5UTR	ENST00000338821	ENST00000528411	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
5CDS-5UTR	ENST00000338821	ENST00000528411	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
In-frame	ENST00000338821	ENST00000393346	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
In-frame	ENST00000338821	ENST00000393346	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
In-frame	ENST00000338821	ENST00000526033	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
In-frame	ENST00000338821	ENST00000526033	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
In-frame	ENST00000338821	ENST00000532317	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
In-frame	ENST00000338821	ENST00000532317	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
intron-3CDS	ENST00000311637	ENST00000393346	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
intron-3CDS	ENST00000311637	ENST00000393346	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
intron-3CDS	ENST00000311637	ENST00000526033	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
intron-3CDS	ENST00000311637	ENST00000526033	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
intron-3CDS	ENST00000311637	ENST00000532317	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
intron-3CDS	ENST00000311637	ENST00000532317	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
intron-3CDS	ENST00000402822	ENST00000393346	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
intron-3CDS	ENST00000402822	ENST00000393346	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
intron-3CDS	ENST00000402822	ENST00000526033	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
intron-3CDS	ENST00000402822	ENST00000526033	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
intron-3CDS	ENST00000402822	ENST00000532317	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
intron-3CDS	ENST00000402822	ENST00000532317	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
intron-3CDS	ENST00000477492	ENST00000393346	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
intron-3CDS	ENST00000477492	ENST00000393346	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
intron-3CDS	ENST00000477492	ENST00000526033	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
intron-3CDS	ENST00000477492	ENST00000526033	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
intron-3CDS	ENST00000477492	ENST00000532317	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
intron-3CDS	ENST00000477492	ENST00000532317	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
intron-5UTR	ENST00000311637	ENST00000356360	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
intron-5UTR	ENST00000311637	ENST00000356360	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
intron-5UTR	ENST00000311637	ENST00000528398	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
intron-5UTR	ENST00000311637	ENST00000528398	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
intron-5UTR	ENST00000311637	ENST00000528411	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
intron-5UTR	ENST00000311637	ENST00000528411	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
intron-5UTR	ENST00000402822	ENST00000356360	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
intron-5UTR	ENST00000402822	ENST00000356360	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
intron-5UTR	ENST00000402822	ENST00000528398	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
intron-5UTR	ENST00000402822	ENST00000528398	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
intron-5UTR	ENST00000402822	ENST00000528411	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
intron-5UTR	ENST00000402822	ENST00000528411	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
intron-5UTR	ENST00000477492	ENST00000356360	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
intron-5UTR	ENST00000477492	ENST00000356360	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
intron-5UTR	ENST00000477492	ENST00000528398	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
intron-5UTR	ENST00000477492	ENST00000528398	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-
intron-5UTR	ENST00000477492	ENST00000528411	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-
intron-5UTR	ENST00000477492	ENST00000528411	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000338821	ATP9A	chr20	50312631	-	ENST00000532317	PICALM	chr11	85742653	-	3877	812	124	2514	796
ENST00000338821	ATP9A	chr20	50312631	-	ENST00000526033	PICALM	chr11	85742653	-	3978	812	124	2619	831
ENST00000338821	ATP9A	chr20	50312631	-	ENST00000393346	PICALM	chr11	85742653	-	2873	812	124	2640	838
ENST00000338821	ATP9A	chr20	50312632	-	ENST00000532317	PICALM	chr11	85742653	-	3877	812	124	2514	796
ENST00000338821	ATP9A	chr20	50312632	-	ENST00000526033	PICALM	chr11	85742653	-	3978	812	124	2619	831
ENST00000338821	ATP9A	chr20	50312632	-	ENST00000393346	PICALM	chr11	85742653	-	2873	812	124	2640	838

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000338821	ENST00000532317	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-	0.000676247	0.9993237
ENST00000338821	ENST00000526033	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-	0.000586146	0.99941385
ENST00000338821	ENST00000393346	ATP9A	chr20	50312631	-	PICALM	chr11	85742653	-	0.001520992	0.99847907
ENST00000338821	ENST00000532317	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-	0.000676247	0.9993237
ENST00000338821	ENST00000526033	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-	0.000586146	0.99941385
ENST00000338821	ENST00000393346	ATP9A	chr20	50312632	-	PICALM	chr11	85742653	-	0.001520992	0.99847907

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Fusion Genomic Features for ATP9A-PICALM

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for ATP9A-PICALM

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:50312631/chr11:85742653)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	PICALM Q13492
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:22118466, PubMed:21808019, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:25241929, PubMed:24067654). {ECO:0000269\|PubMed:10436022, ECO:0000269\|PubMed:16262731, ECO:0000269\|PubMed:21808019, ECO:0000269\|PubMed:22118466, ECO:0000269\|PubMed:23741335, ECO:0000269\|PubMed:24067654, ECO:0000269\|PubMed:25241929, ECO:0000269\|PubMed:25898166, ECO:0000269\|PubMed:27574975}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

2_69

182

1048.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

92_96

182

1048.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

2_69

182

1048.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

92_96

182

1048.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

70_91

182

1048.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

97_119

182

1048.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

70_91

182

1048.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

97_119

182

1048.0

Transmembrane

Helical

Tgene

PICALM

chr20:50312631

chr11:85742653

ENST00000528398

14_145

552.0

Domain

ENTH

Tgene

PICALM

chr20:50312632

chr11:85742653

ENST00000528398

14_145

552.0

Domain

ENTH

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

1000_1006

182

1048.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

1031_1047

182

1048.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

120_303

182

1048.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

326_332

182

1048.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

355_841

182

1048.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

863_874

182

1048.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

894_923

182

1048.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

943_949

182

1048.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

973_978

182

1048.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

1000_1006

927.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

1031_1047

927.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

120_303

927.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

2_69

927.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

326_332

927.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

355_841

927.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

863_874

927.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

894_923

927.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

92_96

927.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

943_949

927.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

973_978

927.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

1000_1006

182

1048.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

1031_1047

182

1048.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

120_303

182

1048.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

326_332

182

1048.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

355_841

182

1048.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

863_874

182

1048.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

894_923

182

1048.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

943_949

182

1048.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

973_978

182

1048.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

1000_1006

927.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

1031_1047

927.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

120_303

927.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

2_69

927.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

326_332

927.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

355_841

927.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

863_874

927.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

894_923

927.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

92_96

927.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

943_949

927.0

Topological domain

Extracellular

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

973_978

927.0

Topological domain

Cytoplasmic

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

1007_1030

182

1048.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

304_325

182

1048.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

333_354

182

1048.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

842_862

182

1048.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

875_893

182

1048.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

924_942

182

1048.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

950_972

182

1048.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000338821

979_999

182

1048.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

1007_1030

927.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

304_325

927.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

333_354

927.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

70_91

927.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

842_862

927.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

875_893

927.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

924_942

927.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

950_972

927.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

979_999

927.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312631

chr11:85742653

ENST00000402822

97_119

927.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

1007_1030

182

1048.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

304_325

182

1048.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

333_354

182

1048.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

842_862

182

1048.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

875_893

182

1048.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

924_942

182

1048.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

950_972

182

1048.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000338821

979_999

182

1048.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

1007_1030

927.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

304_325

927.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

333_354

927.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

70_91

927.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

842_862

927.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

875_893

927.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

924_942

927.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

950_972

927.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

979_999

927.0

Transmembrane

Helical

Hgene

ATP9A

chr20:50312632

chr11:85742653

ENST00000402822

97_119

927.0

Transmembrane

Helical

Tgene

PICALM

chr20:50312631

chr11:85742653

ENST00000356360

14_145

633.0

Domain

ENTH

Tgene

PICALM

chr20:50312631

chr11:85742653

ENST00000393346

14_145

653.0

Domain

ENTH

Tgene

PICALM

chr20:50312631

chr11:85742653

ENST00000526033

14_145

646.0

Domain

ENTH

Tgene

PICALM

chr20:50312631

chr11:85742653

ENST00000532317

14_145

611.0

Domain

ENTH

Tgene

PICALM

chr20:50312632

chr11:85742653

ENST00000356360

14_145

633.0

Domain

ENTH

Tgene

PICALM

chr20:50312632

chr11:85742653

ENST00000393346

14_145

653.0

Domain

ENTH

Tgene

PICALM

chr20:50312632

chr11:85742653

ENST00000526033

14_145

646.0

Domain

ENTH

Tgene

PICALM

chr20:50312632

chr11:85742653

ENST00000532317

14_145

611.0

Domain

ENTH

Top

Fusion Gene Sequence for ATP9A-PICALM

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>8285_8285_1_ATP9A-PICALM_ATP9A_chr20_50312631_ENST00000338821_PICALM_chr11_85742653_ENST00000393346_length(transcript)=2873nt_BP=812nt
GCGCGGCGCGGCGCGGAGCGAGCGGGCGCAGCGCGGAGCTCGGGCCCATGGTGCGCCCGTGTCCGTCGGTCGGGCCGCGCGGGCGCTCCG
CGCGTGGCCCGGCGCTCGCGAGCTCGCCCCCTCGCTGCGGGCCCGGCCCGCCCGCTGCCGCCGCCTCCTCCCCCGGGGCGGCGCGGCGCC
GGCGGGCGGCGGCGCGGAGGCCGGACCGGGCGGCGGCCCAGGCGGCGCGGGGGGCGCGGCGGCCAAGGCGGGCGGCGCCGCCGACATGAC
GGACAACATCCCGCTGCAGCCGGTGCGCCAGAAGAAGCGGATGGACAGCAGGCCCCGCGCCGGGTGCTGCGAGTGGCTGAGATGCTGCGG
TGGAGGGGAGGCCAGGCCCCGCACTGTCTGGCTGGGGCACCCCGAGAAGAGAGACCAGAGGTATCCTCGGAATGTCATCAACAATCAGAA
GTACAATTTCTTCACCTTTCTTCCTGGGGTGCTGTTCAACCAGTTCAAATACTTTTTCAACCTCTATTTCTTACTTCTTGCCTGCTCTCA
GTTTGTTCCCGAAATGAGACTTGGTGCACTCTATACCTACTGGGTTCCCCTGGGCTTCGTGCTGGCCGTCACTGTCATCCGTGAGGCGGT
GGAGGAGATCCGATGCTACGTGCGGGACAAGGAAGTCAACTCCCAGGTCTACAGCCGGCTCACAGCACGAGGCACAGTGAAGGTGAAGAG
TTCTAACATCCAAGTTGGAGACCTTATCATCGTTGAAAAGAACCAGCGGGTCCCTGCCGACATGATCTTCCTGAGGACATCAGAAAAAAA
CGACTTAATTCAGTGCACAAATGAGATGAATGTGAACATCCCACAGTTGGCAGACAGTTTATTTGAAAGAACTACTAATAGTAGTTGGGT
GGTGGTCTTCAAATCTCTCATTACAACTCATCATTTGATGGTGTATGGAAATGAGCGTTTTATTCAGTATTTGGCTTCAAGAAACACGTT
GTTTAACTTAAGCAATTTTTTGGATAAAAGTGGATTGCAAGGATATGACATGTCTACATTTATTAGGCGGTATAGTAGATATTTAAATGA
GAAAGCAGTTTCATACAGACAAGTTGCATTTGATTTCACAAAAGTGAAGAGAGGGGCTGATGGAGTTATGAGAACAATGAACACAGAAAA
ACTCCTAAAAACTGTACCAATTATTCAGAATCAGATGGATGCACTTCTTGATTTTAATGTTAATAGCAATGAACTTACAAATGGGGTAAT
AAATGCTGCCTTCATGCTCCTGTTCAAAGATGCCATTAGACTGTTTGCAGCATACAATGAAGGAATTATTAATTTGTTGGAAAAATATTT
TGATATGAAAAAGAACCAATGCAAAGAAGGTCTTGACATCTATAAGAAGTTCCTAACTAGGATGACAAGAATCTCAGAGTTCCTCAAAGT
TGCAGAGCAAGTTGGAATTGACAGAGGTGATATACCAGACCTTTCACAGGCCCCTAGCAGTCTTCTTGATGCTTTGGAACAACATTTAGC
TTCCTTGGAAGGAAAGAAAATCAAAGATTCTACAGCTGCAAGCAGGGCAACTACACTTTCCAATGCAGTGTCTTCCCTGGCAAGCACTGG
TCTATCTCTGACCAAAGTGGATGAAAGGGAAAAGCAGGCAGCATTAGAGGAAGAACAGGCACGTTTGAAAGCTTTAAAGGAACAGCGCCT
AAAAGAACTTGCAAAGAAACCTCATACCTCTTTAACAACTGCAGCCTCTCCTGTATCCACCTCAGCAGGAGGGATAATGACTGCACCAGC
CATTGACATATTTTCTACCCCTAGTTCTTCTAACAGCACATCAAAGCTGCCCAATGATCTGCTTGATTTGCAGCAGCCAACTTTTCACCC
ATCTGTACATCCTATGTCAACTGCTTCTCAGGTAGCAAGTACATGGGGAGATCCTTTCTCTGCTACTGTAGATGCTGTTGATGATGCCAT
TCCAAGCTTAAATCCTTTCCTCACAAAAAGTAGTGGTGATGTTCACCTTTCCATTTCTTCAGATGTATCTACTTTTACTACTAGGACACC
TACTCATGAAATGTTTGTTGGATTCACTCCTTCTCCAGTTGCACAGCCACACCCTTCAGCTGGCCTTAATGTTGACTTTGAATCTGTGTT
TGGAAATAAATCTACAAATGTTATTGTAGATTCTGGGGGCTTTGATGAACTAGGTGGACTTCTCAAACCAACAGTGGCCTCTCAGAACCA
GAACCTTCCTGTTGCCAAACTCCCACCTAGCAAGTTAGTATCTGATGACTTGGATTCATCTTTAGCCAACCTTGTGGGCAATCTTGGCAT
CGGAAATGGAACCACTAAGAATGATGTAAATTGGAGTCAACCAGGTGAAAAGAAGTTAACTGGGGGATCTAACTGGCAACCAAAGGTTGC
ACCAACAACCGCTTGGAATGCTGCAACAATGGCACCCCCTGTAATGGCCTATCCTGCTACTACACCAACAGGCATGATAGGATATGGAAT
TCCTCCACAAATGGGAAGTGTTCCTGTAATGACGCAACCAACCTTAATATACAGCCAGCCTGTCATGAGACCTCCAAACCCCTTTGGCCC
TGTATCAGGAGCACAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGCTCAAGCAGCAAAATCCTT
ACTTCCAGCAAAATCCAAACTGCTGTCTCTTAAATCTCTTAAACTCTCTTCTTCCATTAGAATGCTACAAGTAACTCAGTGAAGGCCCAT

>8285_8285_1_ATP9A-PICALM_ATP9A_chr20_50312631_ENST00000338821_PICALM_chr11_85742653_ENST00000393346_length(amino acids)=838AA_BP=229
MRARPARCRRLLPRGGAAPAGGGAEAGPGGGPGGAGGAAAKAGGAADMTDNIPLQPVRQKKRMDSRPRAGCCEWLRCCGGGEARPRTVWL
GHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKE
VNSQVYSRLTARGTVKVKSSNIQVGDLIIVEKNQRVPADMIFLRTSEKNDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHH
LMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQ
MDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDI
PDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSL
TTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVDAVDDAIPSLNPFLTKSS
GDVHLSISSDVSTFTTRTPTHEMFVGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSK
LVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATTPTGMIGYGIPPQMGSVPVMT

--------------------------------------------------------------
>8285_8285_2_ATP9A-PICALM_ATP9A_chr20_50312631_ENST00000338821_PICALM_chr11_85742653_ENST00000526033_length(transcript)=3978nt_BP=812nt
GCGCGGCGCGGCGCGGAGCGAGCGGGCGCAGCGCGGAGCTCGGGCCCATGGTGCGCCCGTGTCCGTCGGTCGGGCCGCGCGGGCGCTCCG
CGCGTGGCCCGGCGCTCGCGAGCTCGCCCCCTCGCTGCGGGCCCGGCCCGCCCGCTGCCGCCGCCTCCTCCCCCGGGGCGGCGCGGCGCC
GGCGGGCGGCGGCGCGGAGGCCGGACCGGGCGGCGGCCCAGGCGGCGCGGGGGGCGCGGCGGCCAAGGCGGGCGGCGCCGCCGACATGAC
GGACAACATCCCGCTGCAGCCGGTGCGCCAGAAGAAGCGGATGGACAGCAGGCCCCGCGCCGGGTGCTGCGAGTGGCTGAGATGCTGCGG
TGGAGGGGAGGCCAGGCCCCGCACTGTCTGGCTGGGGCACCCCGAGAAGAGAGACCAGAGGTATCCTCGGAATGTCATCAACAATCAGAA
GTACAATTTCTTCACCTTTCTTCCTGGGGTGCTGTTCAACCAGTTCAAATACTTTTTCAACCTCTATTTCTTACTTCTTGCCTGCTCTCA
GTTTGTTCCCGAAATGAGACTTGGTGCACTCTATACCTACTGGGTTCCCCTGGGCTTCGTGCTGGCCGTCACTGTCATCCGTGAGGCGGT
GGAGGAGATCCGATGCTACGTGCGGGACAAGGAAGTCAACTCCCAGGTCTACAGCCGGCTCACAGCACGAGGCACAGTGAAGGTGAAGAG
TTCTAACATCCAAGTTGGAGACCTTATCATCGTTGAAAAGAACCAGCGGGTCCCTGCCGACATGATCTTCCTGAGGACATCAGAAAAAAA
CGACTTAATTCAGTGCACAAATGAGATGAATGTGAACATCCCACAGTTGGCAGACAGTTTATTTGAAAGAACTACTAATAGTAGTTGGGT
GGTGGTCTTCAAATCTCTCATTACAACTCATCATTTGATGGTGTATGGAAATGAGCGTTTTATTCAGTATTTGGCTTCAAGAAACACGTT
GTTTAACTTAAGCAATTTTTTGGATAAAAGTGGATTGCAAGGATATGACATGTCTACATTTATTAGGCGGTATAGTAGATATTTAAATGA
GAAAGCAGTTTCATACAGACAAGTTGCATTTGATTTCACAAAAGTGAAGAGAGGGGCTGATGGAGTTATGAGAACAATGAACACAGAAAA
ACTCCTAAAAACTGTACCAATTATTCAGAATCAGATGGATGCACTTCTTGATTTTAATGTTAATAGCAATGAACTTACAAATGGGGTAAT
AAATGCTGCCTTCATGCTCCTGTTCAAAGATGCCATTAGACTGTTTGCAGCATACAATGAAGGAATTATTAATTTGTTGGAAAAATATTT
TGATATGAAAAAGAACCAATGCAAAGAAGGTCTTGACATCTATAAGAAGTTCCTAACTAGGATGACAAGAATCTCAGAGTTCCTCAAAGT
TGCAGAGCAAGTTGGAATTGACAGAGGTGATATACCAGACCTTTCACAGGCCCCTAGCAGTCTTCTTGATGCTTTGGAACAACATTTAGC
TTCCTTGGAAGGAAAGAAAATCAAAGATTCTACAGCTGCAAGCAGGGCAACTACACTTTCCAATGCAGTGTCTTCCCTGGCAAGCACTGG
TCTATCTCTGACCAAAGTGGATGAAAGGGAAAAGCAGGCAGCATTAGAGGAAGAACAGGCACGTTTGAAAGCTTTAAAGGAACAGCGCCT
AAAAGAACTTGCAAAGAAACCTCATACCTCTTTAACAACTGCAGCCTCTCCTGTATCCACCTCAGCAGGAGGGATAATGACTGCACCAGC
CATTGACATATTTTCTACCCCTAGTTCTTCTAACAGCACATCAAAGCTGCCCAATGATCTGCTTGATTTGCAGCAGCCAACTTTTCACCC
ATCTGTACATCCTATGTCAACTGCTTCTCAGGTAGCAAGTACATGGGGAGATGCTGTTGATGATGCCATTCCAAGCTTAAATCCTTTCCT
CACAAAAAGTAGTGGTGATGTTCACCTTTCCATTTCTTCAGATGTATCTACTTTTACTACTAGGACACCTACTCATGAAATGTTTGTTGG
ATTCACTCCTTCTCCAGTTGCACAGCCACACCCTTCAGCTGGCCTTAATGTTGACTTTGAATCTGTGTTTGGAAATAAATCTACAAATGT
TATTGTAGATTCTGGGGGCTTTGATGAACTAGGTGGACTTCTCAAACCAACAGTGGCCTCTCAGAACCAGAACCTTCCTGTTGCCAAACT
CCCACCTAGCAAGTTAGTATCTGATGACTTGGATTCATCTTTAGCCAACCTTGTGGGCAATCTTGGCATCGGAAATGGAACCACTAAGAA
TGATGTAAATTGGAGTCAACCAGGTGAAAAGAAGTTAACTGGGGGATCTAACTGGCAACCAAAGGTTGCACCAACAACCGCTTGGAATGC
TGCAACAATGGCACCCCCTGTAATGGCCTATCCTGCTACTACACCAACAGGCATGATAGGATATGGAATTCCTCCACAAATGGGAAGTGT
TCCTGTAATGACGCAACCAACCTTAATATACAGCCAGCCTGTCATGAGACCTCCAAACCCCTTTGGCCCTGTATCAGGAGCACAGATACA
GTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGCTCAAGCAGCAAAATCCTTACTTCCAGCAAAATCCAAACT
GCTGTCTCTTAAATCTCTTAAACTCTCTTCTTCCATTAGAATGCTACAAGTAACTCAGTGAAGGCCCATGAAGGAAATTGGGACTAGTTT
ATAGGAGAACGTATCAATACAGTTTATAAAGCCAAGAATTGCTATGATTTAAGACTAAGATCTGTCTTTTTGGTGACTAACCCTTCAATT
CTTTCAACTCCTGTTAATACCCATAATCAGTAACCTATCAAGAAAAGCCCTTATTTGGAAAGTGTGAAATTTGTATTTGGAAAAGCTGCC
TGGAGAGAAGAACTGTGTCCTTTACTGTATTTCAACAGGACTCTTTTGGGGGATCAAAATTAAAATTCCTAATTATGCATTATCTTTCTT
TTCTCCAGTCCTCACAAATACAGAAACAATAACTGAAATTAACTTTTCTTTTTTTAAAAAAAATTATATTCAGTTTGCAGTAGACATTCC
TTAAGTATTTGTATTTATTTATGATTATCAATTTTACATAACATTAATATTGTATCAGACCTCCTTATGAAAATGAGTATGGATGTGCAC
AGTATGTTTGATTTTTATCCACAAGAATGAATCTGATTCAGAATGCTTTTCTCAGCTGACATACAGAGCACTAAATATTTTAAGGCAAGT
CCATAGGTCTGAATCTCTTAAGAATTCTCGGCCTCTGTGGGATTTAGGGAAGCATTATAAATGCATTAATCCTTATAGTCAATTCTGTGC
CTAGGATTTTGCCAGGGAACAGTTCACTGACTAGGAAAAGCACTACATTTTAAATTCAGCATTAGTGCATTGGGAAGGATCTTTACTGCT
TTGTGCTTGGCATGTCATTATTTTCCATTTGACATTAGGGCCTTTCCAAAATGAATGTGAGGAATTGCTTTCACTTCAAGACTTTCCTTC
TTTTCACTAAAACTCTAGAAGGTGTTACAAGGGGGAGGGAAGGGGGGCAAAGTCCTTGAACATTTTCTTTGGCTCGTGCCATGTTATGAT
CATATACCTTTTAAATAAGGGGAAATAGTATCTTTAAAGTTAATGTCTAGCCAAGAGTTTAGTAAACGAAGAATTAAACTGCACTGTTGA
TCGGTGCTTTGTGTAAATACATCTTTAACATTTGGGTGGAGAGGGGCCTTAAGAAGGACAGTTCATTGTAGGAAAGCAATTCTGTACATG
AGTTTAAGCATTCTTGTTGCATTGTCTCTGCAGATTCTATTTTTGTTTACAATATTAAAATGTATGTTAGCAAAATGGGTGGATTTTCAA

>8285_8285_2_ATP9A-PICALM_ATP9A_chr20_50312631_ENST00000338821_PICALM_chr11_85742653_ENST00000526033_length(amino acids)=831AA_BP=229
MRARPARCRRLLPRGGAAPAGGGAEAGPGGGPGGAGGAAAKAGGAADMTDNIPLQPVRQKKRMDSRPRAGCCEWLRCCGGGEARPRTVWL
GHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKE
VNSQVYSRLTARGTVKVKSSNIQVGDLIIVEKNQRVPADMIFLRTSEKNDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHH
LMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQ
MDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDI
PDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSL
TTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDAVDDAIPSLNPFLTKSSGDVHLSI
SSDVSTFTTRTPTHEMFVGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLD
SSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATTPTGMIGYGIPPQMGSVPVMTQPTLIYS

--------------------------------------------------------------
>8285_8285_3_ATP9A-PICALM_ATP9A_chr20_50312631_ENST00000338821_PICALM_chr11_85742653_ENST00000532317_length(transcript)=3877nt_BP=812nt
GCGCGGCGCGGCGCGGAGCGAGCGGGCGCAGCGCGGAGCTCGGGCCCATGGTGCGCCCGTGTCCGTCGGTCGGGCCGCGCGGGCGCTCCG
CGCGTGGCCCGGCGCTCGCGAGCTCGCCCCCTCGCTGCGGGCCCGGCCCGCCCGCTGCCGCCGCCTCCTCCCCCGGGGCGGCGCGGCGCC
GGCGGGCGGCGGCGCGGAGGCCGGACCGGGCGGCGGCCCAGGCGGCGCGGGGGGCGCGGCGGCCAAGGCGGGCGGCGCCGCCGACATGAC
GGACAACATCCCGCTGCAGCCGGTGCGCCAGAAGAAGCGGATGGACAGCAGGCCCCGCGCCGGGTGCTGCGAGTGGCTGAGATGCTGCGG
TGGAGGGGAGGCCAGGCCCCGCACTGTCTGGCTGGGGCACCCCGAGAAGAGAGACCAGAGGTATCCTCGGAATGTCATCAACAATCAGAA
GTACAATTTCTTCACCTTTCTTCCTGGGGTGCTGTTCAACCAGTTCAAATACTTTTTCAACCTCTATTTCTTACTTCTTGCCTGCTCTCA
GTTTGTTCCCGAAATGAGACTTGGTGCACTCTATACCTACTGGGTTCCCCTGGGCTTCGTGCTGGCCGTCACTGTCATCCGTGAGGCGGT
GGAGGAGATCCGATGCTACGTGCGGGACAAGGAAGTCAACTCCCAGGTCTACAGCCGGCTCACAGCACGAGGCACAGTGAAGGTGAAGAG
TTCTAACATCCAAGTTGGAGACCTTATCATCGTTGAAAAGAACCAGCGGGTCCCTGCCGACATGATCTTCCTGAGGACATCAGAAAAAAA
CGACTTAATTCAGTGCACAAATGAGATGAATGTGAACATCCCACAGTTGGCAGACAGTTTATTTGAAAGAACTACTAATAGTAGTTGGGT
GGTGGTCTTCAAATCTCTCATTACAACTCATCATTTGATGGTGTATGGAAATGAGCGTTTTATTCAGTATTTGGCTTCAAGAAACACGTT
GTTTAACTTAAGCAATTTTTTGGATAAAAGTGGATTGCAAGGATATGACATGTCTACATTTATTAGGCGGTATAGTAGATATTTAAATGA
GAAAGCAGTTTCATACAGACAAGTTGCATTTGATTTCACAAAAGTGAAGAGAGGGGCTGATGGAGTTATGAGAACAATGAACACAGAAAA
ACTCCTAAAAACTGTACCAATTATTCAGAATCAGATGGATGCACTTCTTGATTTTAATGTTAATAGCAATGAACTTACAAATGGGGTAAT
AAATGCTGCCTTCATGCTCCTGTTCAAAGATGCCATTAGACTGTTTGCAGCATACAATGAAGGAATTATTAATTTGTTGGAAAAATATTT
TGATATGAAAAAGAACCAATGCAAAGAAGGTCTTGACATCTATAAGAAGTTCCTAACTAGGATGACAAGAATCTCAGAGTTCCTCAAAGT
TGCAGAGCAAGTTGGAATTGACAGAGGTGATATACCAGACCTTTCACAGGCCCCTAGCAGTCTTCTTGATGCTTTGGAACAACATTTAGC
TTCCTTGGAAGGAAAGAAAATCAAAGATTCTACAGCTGCAAGCAGGGCAACTACACTTTCCAATGCAGTGTCTTCCCTGGCAAGCACTGG
TCTATCTCTGACCAAAGTGGATGAAAGGGAAAAGCAGGCAGCATTAGAGGAAGAACAGGCACGTTTGAAAGCTTTAAAGGAACAGCGCCT
AAAAGAACTTGCAAAGAAACCTCATACCTCTTTAACAACTGCAGCCTCTCCTGTATCCACCTCAGCAGGAGGGATAATGACTGCACCAGC
CATTGACATATTTTCTACCCCTAGTTCTTCTAACAGCACATCAAAGCTGCCCAATGATCTGCTTGATTTGCAGCAGCCAACTTTTCACCC
ATCTGTACATCCTATGTCAACTGCTTCTCAGGTAGCAAGTACATGGGGAGGATTCACTCCTTCTCCAGTTGCACAGCCACACCCTTCAGC
TGGCCTTAATGTTGACTTTGAATCTGTGTTTGGAAATAAATCTACAAATGTTATTGTAGATTCTGGGGGCTTTGATGAACTAGGTGGACT
TCTCAAACCAACAGTGGCCTCTCAGAACCAGAACCTTCCTGTTGCCAAACTCCCACCTAGCAAGTTAGTATCTGATGACTTGGATTCATC
TTTAGCCAACCTTGTGGGCAATCTTGGCATCGGAAATGGAACCACTAAGAATGATGTAAATTGGAGTCAACCAGGTGAAAAGAAGTTAAC
TGGGGGATCTAACTGGCAACCAAAGGTTGCACCAACAACCGCTTGGAATGCTGCAACAATGAATGGCATGCATTTTCCACAATACGCACC
CCCTGTAATGGCCTATCCTGCTACTACACCAACAGGCATGATAGGATATGGAATTCCTCCACAAATGGGAAGTGTTCCTGTAATGACGCA
ACCAACCTTAATATACAGCCAGCCTGTCATGAGACCTCCAAACCCCTTTGGCCCTGTATCAGGAGCACAGATACAGTTTATGTAACTTGA
TGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGCTCAAGCAGCAAAATCCTTACTTCCAGCAAAATCCAAACTGCTGTCTCTTAAATC
TCTTAAACTCTCTTCTTCCATTAGAATGCTACAAGTAACTCAGTGAAGGCCCATGAAGGAAATTGGGACTAGTTTATAGGAGAACGTATC
AATACAGTTTATAAAGCCAAGAATTGCTATGATTTAAGACTAAGATCTGTCTTTTTGGTGACTAACCCTTCAATTCTTTCAACTCCTGTT
AATACCCATAATCAGTAACCTATCAAGAAAAGCCCTTATTTGGAAAGTGTGAAATTTGTATTTGGAAAAGCTGCCTGGAGAGAAGAACTG
TGTCCTTTACTGTATTTCAACAGGACTCTTTTGGGGGATCAAAATTAAAATTCCTAATTATGCATTATCTTTCTTTTCTCCAGTCCTCAC
AAATACAGAAACAATAACTGAAATTAACTTTTCTTTTTTTAAAAAAAATTATATTCAGTTTGCAGTAGACATTCCTTAAGTATTTGTATT
TATTTATGATTATCAATTTTACATAACATTAATATTGTATCAGACCTCCTTATGAAAATGAGTATGGATGTGCACAGTATGTTTGATTTT
TATCCACAAGAATGAATCTGATTCAGAATGCTTTTCTCAGCTGACATACAGAGCACTAAATATTTTAAGGCAAGTCCATAGGTCTGAATC
TCTTAAGAATTCTCGGCCTCTGTGGGATTTAGGGAAGCATTATAAATGCATTAATCCTTATAGTCAATTCTGTGCCTAGGATTTTGCCAG
GGAACAGTTCACTGACTAGGAAAAGCACTACATTTTAAATTCAGCATTAGTGCATTGGGAAGGATCTTTACTGCTTTGTGCTTGGCATGT
CATTATTTTCCATTTGACATTAGGGCCTTTCCAAAATGAATGTGAGGAATTGCTTTCACTTCAAGACTTTCCTTCTTTTCACTAAAACTC
TAGAAGGTGTTACAAGGGGGAGGGAAGGGGGGCAAAGTCCTTGAACATTTTCTTTGGCTCGTGCCATGTTATGATCATATACCTTTTAAA
TAAGGGGAAATAGTATCTTTAAAGTTAATGTCTAGCCAAGAGTTTAGTAAACGAAGAATTAAACTGCACTGTTGATCGGTGCTTTGTGTA
AATACATCTTTAACATTTGGGTGGAGAGGGGCCTTAAGAAGGACAGTTCATTGTAGGAAAGCAATTCTGTACATGAGTTTAAGCATTCTT
GTTGCATTGTCTCTGCAGATTCTATTTTTGTTTACAATATTAAAATGTATGTTAGCAAAATGGGTGGATTTTCAAATAAAATGCAGCTTC

>8285_8285_3_ATP9A-PICALM_ATP9A_chr20_50312631_ENST00000338821_PICALM_chr11_85742653_ENST00000532317_length(amino acids)=796AA_BP=229
MRARPARCRRLLPRGGAAPAGGGAEAGPGGGPGGAGGAAAKAGGAADMTDNIPLQPVRQKKRMDSRPRAGCCEWLRCCGGGEARPRTVWL
GHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKE
VNSQVYSRLTARGTVKVKSSNIQVGDLIIVEKNQRVPADMIFLRTSEKNDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHH
LMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQ
MDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDI
PDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSL
TTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGGFTPSPVAQPHPSAGLNVDFESVFG
NKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAP

--------------------------------------------------------------
>8285_8285_4_ATP9A-PICALM_ATP9A_chr20_50312632_ENST00000338821_PICALM_chr11_85742653_ENST00000393346_length(transcript)=2873nt_BP=812nt
GCGCGGCGCGGCGCGGAGCGAGCGGGCGCAGCGCGGAGCTCGGGCCCATGGTGCGCCCGTGTCCGTCGGTCGGGCCGCGCGGGCGCTCCG
CGCGTGGCCCGGCGCTCGCGAGCTCGCCCCCTCGCTGCGGGCCCGGCCCGCCCGCTGCCGCCGCCTCCTCCCCCGGGGCGGCGCGGCGCC
GGCGGGCGGCGGCGCGGAGGCCGGACCGGGCGGCGGCCCAGGCGGCGCGGGGGGCGCGGCGGCCAAGGCGGGCGGCGCCGCCGACATGAC
GGACAACATCCCGCTGCAGCCGGTGCGCCAGAAGAAGCGGATGGACAGCAGGCCCCGCGCCGGGTGCTGCGAGTGGCTGAGATGCTGCGG
TGGAGGGGAGGCCAGGCCCCGCACTGTCTGGCTGGGGCACCCCGAGAAGAGAGACCAGAGGTATCCTCGGAATGTCATCAACAATCAGAA
GTACAATTTCTTCACCTTTCTTCCTGGGGTGCTGTTCAACCAGTTCAAATACTTTTTCAACCTCTATTTCTTACTTCTTGCCTGCTCTCA
GTTTGTTCCCGAAATGAGACTTGGTGCACTCTATACCTACTGGGTTCCCCTGGGCTTCGTGCTGGCCGTCACTGTCATCCGTGAGGCGGT
GGAGGAGATCCGATGCTACGTGCGGGACAAGGAAGTCAACTCCCAGGTCTACAGCCGGCTCACAGCACGAGGCACAGTGAAGGTGAAGAG
TTCTAACATCCAAGTTGGAGACCTTATCATCGTTGAAAAGAACCAGCGGGTCCCTGCCGACATGATCTTCCTGAGGACATCAGAAAAAAA
CGACTTAATTCAGTGCACAAATGAGATGAATGTGAACATCCCACAGTTGGCAGACAGTTTATTTGAAAGAACTACTAATAGTAGTTGGGT
GGTGGTCTTCAAATCTCTCATTACAACTCATCATTTGATGGTGTATGGAAATGAGCGTTTTATTCAGTATTTGGCTTCAAGAAACACGTT
GTTTAACTTAAGCAATTTTTTGGATAAAAGTGGATTGCAAGGATATGACATGTCTACATTTATTAGGCGGTATAGTAGATATTTAAATGA
GAAAGCAGTTTCATACAGACAAGTTGCATTTGATTTCACAAAAGTGAAGAGAGGGGCTGATGGAGTTATGAGAACAATGAACACAGAAAA
ACTCCTAAAAACTGTACCAATTATTCAGAATCAGATGGATGCACTTCTTGATTTTAATGTTAATAGCAATGAACTTACAAATGGGGTAAT
AAATGCTGCCTTCATGCTCCTGTTCAAAGATGCCATTAGACTGTTTGCAGCATACAATGAAGGAATTATTAATTTGTTGGAAAAATATTT
TGATATGAAAAAGAACCAATGCAAAGAAGGTCTTGACATCTATAAGAAGTTCCTAACTAGGATGACAAGAATCTCAGAGTTCCTCAAAGT
TGCAGAGCAAGTTGGAATTGACAGAGGTGATATACCAGACCTTTCACAGGCCCCTAGCAGTCTTCTTGATGCTTTGGAACAACATTTAGC
TTCCTTGGAAGGAAAGAAAATCAAAGATTCTACAGCTGCAAGCAGGGCAACTACACTTTCCAATGCAGTGTCTTCCCTGGCAAGCACTGG
TCTATCTCTGACCAAAGTGGATGAAAGGGAAAAGCAGGCAGCATTAGAGGAAGAACAGGCACGTTTGAAAGCTTTAAAGGAACAGCGCCT
AAAAGAACTTGCAAAGAAACCTCATACCTCTTTAACAACTGCAGCCTCTCCTGTATCCACCTCAGCAGGAGGGATAATGACTGCACCAGC
CATTGACATATTTTCTACCCCTAGTTCTTCTAACAGCACATCAAAGCTGCCCAATGATCTGCTTGATTTGCAGCAGCCAACTTTTCACCC
ATCTGTACATCCTATGTCAACTGCTTCTCAGGTAGCAAGTACATGGGGAGATCCTTTCTCTGCTACTGTAGATGCTGTTGATGATGCCAT
TCCAAGCTTAAATCCTTTCCTCACAAAAAGTAGTGGTGATGTTCACCTTTCCATTTCTTCAGATGTATCTACTTTTACTACTAGGACACC
TACTCATGAAATGTTTGTTGGATTCACTCCTTCTCCAGTTGCACAGCCACACCCTTCAGCTGGCCTTAATGTTGACTTTGAATCTGTGTT
TGGAAATAAATCTACAAATGTTATTGTAGATTCTGGGGGCTTTGATGAACTAGGTGGACTTCTCAAACCAACAGTGGCCTCTCAGAACCA
GAACCTTCCTGTTGCCAAACTCCCACCTAGCAAGTTAGTATCTGATGACTTGGATTCATCTTTAGCCAACCTTGTGGGCAATCTTGGCAT
CGGAAATGGAACCACTAAGAATGATGTAAATTGGAGTCAACCAGGTGAAAAGAAGTTAACTGGGGGATCTAACTGGCAACCAAAGGTTGC
ACCAACAACCGCTTGGAATGCTGCAACAATGGCACCCCCTGTAATGGCCTATCCTGCTACTACACCAACAGGCATGATAGGATATGGAAT
TCCTCCACAAATGGGAAGTGTTCCTGTAATGACGCAACCAACCTTAATATACAGCCAGCCTGTCATGAGACCTCCAAACCCCTTTGGCCC
TGTATCAGGAGCACAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGCTCAAGCAGCAAAATCCTT
ACTTCCAGCAAAATCCAAACTGCTGTCTCTTAAATCTCTTAAACTCTCTTCTTCCATTAGAATGCTACAAGTAACTCAGTGAAGGCCCAT

>8285_8285_4_ATP9A-PICALM_ATP9A_chr20_50312632_ENST00000338821_PICALM_chr11_85742653_ENST00000393346_length(amino acids)=838AA_BP=229
MRARPARCRRLLPRGGAAPAGGGAEAGPGGGPGGAGGAAAKAGGAADMTDNIPLQPVRQKKRMDSRPRAGCCEWLRCCGGGEARPRTVWL
GHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKE
VNSQVYSRLTARGTVKVKSSNIQVGDLIIVEKNQRVPADMIFLRTSEKNDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHH
LMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQ
MDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDI
PDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSL
TTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVDAVDDAIPSLNPFLTKSS
GDVHLSISSDVSTFTTRTPTHEMFVGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSK
LVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATTPTGMIGYGIPPQMGSVPVMT

--------------------------------------------------------------
>8285_8285_5_ATP9A-PICALM_ATP9A_chr20_50312632_ENST00000338821_PICALM_chr11_85742653_ENST00000526033_length(transcript)=3978nt_BP=812nt
GCGCGGCGCGGCGCGGAGCGAGCGGGCGCAGCGCGGAGCTCGGGCCCATGGTGCGCCCGTGTCCGTCGGTCGGGCCGCGCGGGCGCTCCG
CGCGTGGCCCGGCGCTCGCGAGCTCGCCCCCTCGCTGCGGGCCCGGCCCGCCCGCTGCCGCCGCCTCCTCCCCCGGGGCGGCGCGGCGCC
GGCGGGCGGCGGCGCGGAGGCCGGACCGGGCGGCGGCCCAGGCGGCGCGGGGGGCGCGGCGGCCAAGGCGGGCGGCGCCGCCGACATGAC
GGACAACATCCCGCTGCAGCCGGTGCGCCAGAAGAAGCGGATGGACAGCAGGCCCCGCGCCGGGTGCTGCGAGTGGCTGAGATGCTGCGG
TGGAGGGGAGGCCAGGCCCCGCACTGTCTGGCTGGGGCACCCCGAGAAGAGAGACCAGAGGTATCCTCGGAATGTCATCAACAATCAGAA
GTACAATTTCTTCACCTTTCTTCCTGGGGTGCTGTTCAACCAGTTCAAATACTTTTTCAACCTCTATTTCTTACTTCTTGCCTGCTCTCA
GTTTGTTCCCGAAATGAGACTTGGTGCACTCTATACCTACTGGGTTCCCCTGGGCTTCGTGCTGGCCGTCACTGTCATCCGTGAGGCGGT
GGAGGAGATCCGATGCTACGTGCGGGACAAGGAAGTCAACTCCCAGGTCTACAGCCGGCTCACAGCACGAGGCACAGTGAAGGTGAAGAG
TTCTAACATCCAAGTTGGAGACCTTATCATCGTTGAAAAGAACCAGCGGGTCCCTGCCGACATGATCTTCCTGAGGACATCAGAAAAAAA
CGACTTAATTCAGTGCACAAATGAGATGAATGTGAACATCCCACAGTTGGCAGACAGTTTATTTGAAAGAACTACTAATAGTAGTTGGGT
GGTGGTCTTCAAATCTCTCATTACAACTCATCATTTGATGGTGTATGGAAATGAGCGTTTTATTCAGTATTTGGCTTCAAGAAACACGTT
GTTTAACTTAAGCAATTTTTTGGATAAAAGTGGATTGCAAGGATATGACATGTCTACATTTATTAGGCGGTATAGTAGATATTTAAATGA
GAAAGCAGTTTCATACAGACAAGTTGCATTTGATTTCACAAAAGTGAAGAGAGGGGCTGATGGAGTTATGAGAACAATGAACACAGAAAA
ACTCCTAAAAACTGTACCAATTATTCAGAATCAGATGGATGCACTTCTTGATTTTAATGTTAATAGCAATGAACTTACAAATGGGGTAAT
AAATGCTGCCTTCATGCTCCTGTTCAAAGATGCCATTAGACTGTTTGCAGCATACAATGAAGGAATTATTAATTTGTTGGAAAAATATTT
TGATATGAAAAAGAACCAATGCAAAGAAGGTCTTGACATCTATAAGAAGTTCCTAACTAGGATGACAAGAATCTCAGAGTTCCTCAAAGT
TGCAGAGCAAGTTGGAATTGACAGAGGTGATATACCAGACCTTTCACAGGCCCCTAGCAGTCTTCTTGATGCTTTGGAACAACATTTAGC
TTCCTTGGAAGGAAAGAAAATCAAAGATTCTACAGCTGCAAGCAGGGCAACTACACTTTCCAATGCAGTGTCTTCCCTGGCAAGCACTGG
TCTATCTCTGACCAAAGTGGATGAAAGGGAAAAGCAGGCAGCATTAGAGGAAGAACAGGCACGTTTGAAAGCTTTAAAGGAACAGCGCCT
AAAAGAACTTGCAAAGAAACCTCATACCTCTTTAACAACTGCAGCCTCTCCTGTATCCACCTCAGCAGGAGGGATAATGACTGCACCAGC
CATTGACATATTTTCTACCCCTAGTTCTTCTAACAGCACATCAAAGCTGCCCAATGATCTGCTTGATTTGCAGCAGCCAACTTTTCACCC
ATCTGTACATCCTATGTCAACTGCTTCTCAGGTAGCAAGTACATGGGGAGATGCTGTTGATGATGCCATTCCAAGCTTAAATCCTTTCCT
CACAAAAAGTAGTGGTGATGTTCACCTTTCCATTTCTTCAGATGTATCTACTTTTACTACTAGGACACCTACTCATGAAATGTTTGTTGG
ATTCACTCCTTCTCCAGTTGCACAGCCACACCCTTCAGCTGGCCTTAATGTTGACTTTGAATCTGTGTTTGGAAATAAATCTACAAATGT
TATTGTAGATTCTGGGGGCTTTGATGAACTAGGTGGACTTCTCAAACCAACAGTGGCCTCTCAGAACCAGAACCTTCCTGTTGCCAAACT
CCCACCTAGCAAGTTAGTATCTGATGACTTGGATTCATCTTTAGCCAACCTTGTGGGCAATCTTGGCATCGGAAATGGAACCACTAAGAA
TGATGTAAATTGGAGTCAACCAGGTGAAAAGAAGTTAACTGGGGGATCTAACTGGCAACCAAAGGTTGCACCAACAACCGCTTGGAATGC
TGCAACAATGGCACCCCCTGTAATGGCCTATCCTGCTACTACACCAACAGGCATGATAGGATATGGAATTCCTCCACAAATGGGAAGTGT
TCCTGTAATGACGCAACCAACCTTAATATACAGCCAGCCTGTCATGAGACCTCCAAACCCCTTTGGCCCTGTATCAGGAGCACAGATACA
GTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGCTCAAGCAGCAAAATCCTTACTTCCAGCAAAATCCAAACT
GCTGTCTCTTAAATCTCTTAAACTCTCTTCTTCCATTAGAATGCTACAAGTAACTCAGTGAAGGCCCATGAAGGAAATTGGGACTAGTTT
ATAGGAGAACGTATCAATACAGTTTATAAAGCCAAGAATTGCTATGATTTAAGACTAAGATCTGTCTTTTTGGTGACTAACCCTTCAATT
CTTTCAACTCCTGTTAATACCCATAATCAGTAACCTATCAAGAAAAGCCCTTATTTGGAAAGTGTGAAATTTGTATTTGGAAAAGCTGCC
TGGAGAGAAGAACTGTGTCCTTTACTGTATTTCAACAGGACTCTTTTGGGGGATCAAAATTAAAATTCCTAATTATGCATTATCTTTCTT
TTCTCCAGTCCTCACAAATACAGAAACAATAACTGAAATTAACTTTTCTTTTTTTAAAAAAAATTATATTCAGTTTGCAGTAGACATTCC
TTAAGTATTTGTATTTATTTATGATTATCAATTTTACATAACATTAATATTGTATCAGACCTCCTTATGAAAATGAGTATGGATGTGCAC
AGTATGTTTGATTTTTATCCACAAGAATGAATCTGATTCAGAATGCTTTTCTCAGCTGACATACAGAGCACTAAATATTTTAAGGCAAGT
CCATAGGTCTGAATCTCTTAAGAATTCTCGGCCTCTGTGGGATTTAGGGAAGCATTATAAATGCATTAATCCTTATAGTCAATTCTGTGC
CTAGGATTTTGCCAGGGAACAGTTCACTGACTAGGAAAAGCACTACATTTTAAATTCAGCATTAGTGCATTGGGAAGGATCTTTACTGCT
TTGTGCTTGGCATGTCATTATTTTCCATTTGACATTAGGGCCTTTCCAAAATGAATGTGAGGAATTGCTTTCACTTCAAGACTTTCCTTC
TTTTCACTAAAACTCTAGAAGGTGTTACAAGGGGGAGGGAAGGGGGGCAAAGTCCTTGAACATTTTCTTTGGCTCGTGCCATGTTATGAT
CATATACCTTTTAAATAAGGGGAAATAGTATCTTTAAAGTTAATGTCTAGCCAAGAGTTTAGTAAACGAAGAATTAAACTGCACTGTTGA
TCGGTGCTTTGTGTAAATACATCTTTAACATTTGGGTGGAGAGGGGCCTTAAGAAGGACAGTTCATTGTAGGAAAGCAATTCTGTACATG
AGTTTAAGCATTCTTGTTGCATTGTCTCTGCAGATTCTATTTTTGTTTACAATATTAAAATGTATGTTAGCAAAATGGGTGGATTTTCAA

>8285_8285_5_ATP9A-PICALM_ATP9A_chr20_50312632_ENST00000338821_PICALM_chr11_85742653_ENST00000526033_length(amino acids)=831AA_BP=229
MRARPARCRRLLPRGGAAPAGGGAEAGPGGGPGGAGGAAAKAGGAADMTDNIPLQPVRQKKRMDSRPRAGCCEWLRCCGGGEARPRTVWL
GHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKE
VNSQVYSRLTARGTVKVKSSNIQVGDLIIVEKNQRVPADMIFLRTSEKNDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHH
LMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQ
MDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDI
PDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSL
TTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDAVDDAIPSLNPFLTKSSGDVHLSI
SSDVSTFTTRTPTHEMFVGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLD
SSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATTPTGMIGYGIPPQMGSVPVMTQPTLIYS

--------------------------------------------------------------
>8285_8285_6_ATP9A-PICALM_ATP9A_chr20_50312632_ENST00000338821_PICALM_chr11_85742653_ENST00000532317_length(transcript)=3877nt_BP=812nt
GCGCGGCGCGGCGCGGAGCGAGCGGGCGCAGCGCGGAGCTCGGGCCCATGGTGCGCCCGTGTCCGTCGGTCGGGCCGCGCGGGCGCTCCG
CGCGTGGCCCGGCGCTCGCGAGCTCGCCCCCTCGCTGCGGGCCCGGCCCGCCCGCTGCCGCCGCCTCCTCCCCCGGGGCGGCGCGGCGCC
GGCGGGCGGCGGCGCGGAGGCCGGACCGGGCGGCGGCCCAGGCGGCGCGGGGGGCGCGGCGGCCAAGGCGGGCGGCGCCGCCGACATGAC
GGACAACATCCCGCTGCAGCCGGTGCGCCAGAAGAAGCGGATGGACAGCAGGCCCCGCGCCGGGTGCTGCGAGTGGCTGAGATGCTGCGG
TGGAGGGGAGGCCAGGCCCCGCACTGTCTGGCTGGGGCACCCCGAGAAGAGAGACCAGAGGTATCCTCGGAATGTCATCAACAATCAGAA
GTACAATTTCTTCACCTTTCTTCCTGGGGTGCTGTTCAACCAGTTCAAATACTTTTTCAACCTCTATTTCTTACTTCTTGCCTGCTCTCA
GTTTGTTCCCGAAATGAGACTTGGTGCACTCTATACCTACTGGGTTCCCCTGGGCTTCGTGCTGGCCGTCACTGTCATCCGTGAGGCGGT
GGAGGAGATCCGATGCTACGTGCGGGACAAGGAAGTCAACTCCCAGGTCTACAGCCGGCTCACAGCACGAGGCACAGTGAAGGTGAAGAG
TTCTAACATCCAAGTTGGAGACCTTATCATCGTTGAAAAGAACCAGCGGGTCCCTGCCGACATGATCTTCCTGAGGACATCAGAAAAAAA
CGACTTAATTCAGTGCACAAATGAGATGAATGTGAACATCCCACAGTTGGCAGACAGTTTATTTGAAAGAACTACTAATAGTAGTTGGGT
GGTGGTCTTCAAATCTCTCATTACAACTCATCATTTGATGGTGTATGGAAATGAGCGTTTTATTCAGTATTTGGCTTCAAGAAACACGTT
GTTTAACTTAAGCAATTTTTTGGATAAAAGTGGATTGCAAGGATATGACATGTCTACATTTATTAGGCGGTATAGTAGATATTTAAATGA
GAAAGCAGTTTCATACAGACAAGTTGCATTTGATTTCACAAAAGTGAAGAGAGGGGCTGATGGAGTTATGAGAACAATGAACACAGAAAA
ACTCCTAAAAACTGTACCAATTATTCAGAATCAGATGGATGCACTTCTTGATTTTAATGTTAATAGCAATGAACTTACAAATGGGGTAAT
AAATGCTGCCTTCATGCTCCTGTTCAAAGATGCCATTAGACTGTTTGCAGCATACAATGAAGGAATTATTAATTTGTTGGAAAAATATTT
TGATATGAAAAAGAACCAATGCAAAGAAGGTCTTGACATCTATAAGAAGTTCCTAACTAGGATGACAAGAATCTCAGAGTTCCTCAAAGT
TGCAGAGCAAGTTGGAATTGACAGAGGTGATATACCAGACCTTTCACAGGCCCCTAGCAGTCTTCTTGATGCTTTGGAACAACATTTAGC
TTCCTTGGAAGGAAAGAAAATCAAAGATTCTACAGCTGCAAGCAGGGCAACTACACTTTCCAATGCAGTGTCTTCCCTGGCAAGCACTGG
TCTATCTCTGACCAAAGTGGATGAAAGGGAAAAGCAGGCAGCATTAGAGGAAGAACAGGCACGTTTGAAAGCTTTAAAGGAACAGCGCCT
AAAAGAACTTGCAAAGAAACCTCATACCTCTTTAACAACTGCAGCCTCTCCTGTATCCACCTCAGCAGGAGGGATAATGACTGCACCAGC
CATTGACATATTTTCTACCCCTAGTTCTTCTAACAGCACATCAAAGCTGCCCAATGATCTGCTTGATTTGCAGCAGCCAACTTTTCACCC
ATCTGTACATCCTATGTCAACTGCTTCTCAGGTAGCAAGTACATGGGGAGGATTCACTCCTTCTCCAGTTGCACAGCCACACCCTTCAGC
TGGCCTTAATGTTGACTTTGAATCTGTGTTTGGAAATAAATCTACAAATGTTATTGTAGATTCTGGGGGCTTTGATGAACTAGGTGGACT
TCTCAAACCAACAGTGGCCTCTCAGAACCAGAACCTTCCTGTTGCCAAACTCCCACCTAGCAAGTTAGTATCTGATGACTTGGATTCATC
TTTAGCCAACCTTGTGGGCAATCTTGGCATCGGAAATGGAACCACTAAGAATGATGTAAATTGGAGTCAACCAGGTGAAAAGAAGTTAAC
TGGGGGATCTAACTGGCAACCAAAGGTTGCACCAACAACCGCTTGGAATGCTGCAACAATGAATGGCATGCATTTTCCACAATACGCACC
CCCTGTAATGGCCTATCCTGCTACTACACCAACAGGCATGATAGGATATGGAATTCCTCCACAAATGGGAAGTGTTCCTGTAATGACGCA
ACCAACCTTAATATACAGCCAGCCTGTCATGAGACCTCCAAACCCCTTTGGCCCTGTATCAGGAGCACAGATACAGTTTATGTAACTTGA
TGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGCTCAAGCAGCAAAATCCTTACTTCCAGCAAAATCCAAACTGCTGTCTCTTAAATC
TCTTAAACTCTCTTCTTCCATTAGAATGCTACAAGTAACTCAGTGAAGGCCCATGAAGGAAATTGGGACTAGTTTATAGGAGAACGTATC
AATACAGTTTATAAAGCCAAGAATTGCTATGATTTAAGACTAAGATCTGTCTTTTTGGTGACTAACCCTTCAATTCTTTCAACTCCTGTT
AATACCCATAATCAGTAACCTATCAAGAAAAGCCCTTATTTGGAAAGTGTGAAATTTGTATTTGGAAAAGCTGCCTGGAGAGAAGAACTG
TGTCCTTTACTGTATTTCAACAGGACTCTTTTGGGGGATCAAAATTAAAATTCCTAATTATGCATTATCTTTCTTTTCTCCAGTCCTCAC
AAATACAGAAACAATAACTGAAATTAACTTTTCTTTTTTTAAAAAAAATTATATTCAGTTTGCAGTAGACATTCCTTAAGTATTTGTATT
TATTTATGATTATCAATTTTACATAACATTAATATTGTATCAGACCTCCTTATGAAAATGAGTATGGATGTGCACAGTATGTTTGATTTT
TATCCACAAGAATGAATCTGATTCAGAATGCTTTTCTCAGCTGACATACAGAGCACTAAATATTTTAAGGCAAGTCCATAGGTCTGAATC
TCTTAAGAATTCTCGGCCTCTGTGGGATTTAGGGAAGCATTATAAATGCATTAATCCTTATAGTCAATTCTGTGCCTAGGATTTTGCCAG
GGAACAGTTCACTGACTAGGAAAAGCACTACATTTTAAATTCAGCATTAGTGCATTGGGAAGGATCTTTACTGCTTTGTGCTTGGCATGT
CATTATTTTCCATTTGACATTAGGGCCTTTCCAAAATGAATGTGAGGAATTGCTTTCACTTCAAGACTTTCCTTCTTTTCACTAAAACTC
TAGAAGGTGTTACAAGGGGGAGGGAAGGGGGGCAAAGTCCTTGAACATTTTCTTTGGCTCGTGCCATGTTATGATCATATACCTTTTAAA
TAAGGGGAAATAGTATCTTTAAAGTTAATGTCTAGCCAAGAGTTTAGTAAACGAAGAATTAAACTGCACTGTTGATCGGTGCTTTGTGTA
AATACATCTTTAACATTTGGGTGGAGAGGGGCCTTAAGAAGGACAGTTCATTGTAGGAAAGCAATTCTGTACATGAGTTTAAGCATTCTT
GTTGCATTGTCTCTGCAGATTCTATTTTTGTTTACAATATTAAAATGTATGTTAGCAAAATGGGTGGATTTTCAAATAAAATGCAGCTTC

>8285_8285_6_ATP9A-PICALM_ATP9A_chr20_50312632_ENST00000338821_PICALM_chr11_85742653_ENST00000532317_length(amino acids)=796AA_BP=229
MRARPARCRRLLPRGGAAPAGGGAEAGPGGGPGGAGGAAAKAGGAADMTDNIPLQPVRQKKRMDSRPRAGCCEWLRCCGGGEARPRTVWL
GHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKE
VNSQVYSRLTARGTVKVKSSNIQVGDLIIVEKNQRVPADMIFLRTSEKNDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHH
LMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQ
MDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDI
PDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSL
TTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGGFTPSPVAQPHPSAGLNVDFESVFG
NKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAP

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Fusion Gene PPI Analysis for ATP9A-PICALM

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	PICALM	chr20:50312631	chr11:85742653	ENST00000356360		0	19	221_294	43.333333333333336	633.0	PIMREG
Tgene	PICALM	chr20:50312631	chr11:85742653	ENST00000393346		0	20	221_294	43.333333333333336	653.0	PIMREG
Tgene	PICALM	chr20:50312631	chr11:85742653	ENST00000526033		0	20	221_294	43.333333333333336	646.0	PIMREG
Tgene	PICALM	chr20:50312631	chr11:85742653	ENST00000528398		0	19	221_294	0	552.0	PIMREG
Tgene	PICALM	chr20:50312631	chr11:85742653	ENST00000532317		0	20	221_294	43.333333333333336	611.0	PIMREG
Tgene	PICALM	chr20:50312632	chr11:85742653	ENST00000356360		0	19	221_294	43.333333333333336	633.0	PIMREG
Tgene	PICALM	chr20:50312632	chr11:85742653	ENST00000393346		0	20	221_294	43.333333333333336	653.0	PIMREG
Tgene	PICALM	chr20:50312632	chr11:85742653	ENST00000526033		0	20	221_294	43.333333333333336	646.0	PIMREG
Tgene	PICALM	chr20:50312632	chr11:85742653	ENST00000528398		0	19	221_294	0	552.0	PIMREG
Tgene	PICALM	chr20:50312632	chr11:85742653	ENST00000532317		0	20	221_294	43.333333333333336	611.0	PIMREG

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ATP9A-PICALM

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ATP9A-PICALM

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C0002395	Alzheimer's Disease	2	CTD_human
Tgene		C0011265	Presenile dementia	2	CTD_human
Tgene		C0276496	Familial Alzheimer Disease (FAD)	2	CTD_human
Tgene		C0494463	Alzheimer Disease, Late Onset	2	CTD_human
Tgene		C0546126	Acute Confusional Senile Dementia	2	CTD_human
Tgene		C0750900	Alzheimer's Disease, Focal Onset	2	CTD_human
Tgene		C0750901	Alzheimer Disease, Early Onset	2	CTD_human
Tgene		C0234985	Mental deterioration	1	CTD_human
Tgene		C0338656	Impaired cognition	1	CTD_human
Tgene		C1270972	Mild cognitive disorder	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:ATP9A-PICALM (FusionGDB2 ID:HG10079TG8301)

Fusion Gene Summary for ATP9A-PICALM

Fusion Gene ORF analysis for ATP9A-PICALM

Fusion Genomic Features for ATP9A-PICALM

Fusion Protein Features for ATP9A-PICALM

Fusion Gene Sequence for ATP9A-PICALM

Fusion Gene PPI Analysis for ATP9A-PICALM

Related Drugs for ATP9A-PICALM

Related Diseases for ATP9A-PICALM

Fusion Gene Studies
in Kim Lab