![]() |
||||||
|
![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ACTR3-IGHG1 (FusionGDB2 ID:HG10096TG3500) |
Fusion Gene Summary for ACTR3-IGHG1 |
![]() |
Fusion gene information | Fusion gene name: ACTR3-IGHG1 | Fusion gene ID: hg10096tg3500 | Hgene | Tgene | Gene symbol | ACTR3 | IGHG1 | Gene ID | 10096 | 3500 |
Gene name | actin related protein 3 | ||
Synonyms | ARP3 | ||
Cytomap | ('ACTR3')('IGHG1') 2q14.1 | ||
Type of gene | protein-coding | ||
Description | actin-related protein 3ARP3 actin related protein 3 homologactin-like protein 3 | ||
Modification date | 20200327 | ||
UniProtAcc | . | P01857 | |
Ensembl transtripts involved in fusion gene | ENST00000536059, ENST00000263238, ENST00000535589, | ||
Fusion gene scores | * DoF score | 12 X 10 X 6=720 | 95 X 52 X 17=83980 |
# samples | 13 | 116 | |
** MAII score | log2(13/720*10)=-2.46948528330122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(116/83980*10)=-6.17784907770745 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACTR3 [Title/Abstract] AND IGHG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ACTR3(114647889)-IGHG1(106208463), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | ACTR3-IGHG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ACTR3 | GO:0034314 | Arp2/3 complex-mediated actin nucleation | 11741539|17220302 |
Hgene | ACTR3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17220302 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Top |
Fusion Gene ORF analysis for ACTR3-IGHG1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for ACTR3-IGHG1 |
![]() |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Top |
Fusion Protein Features for ACTR3-IGHG1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:114647889/:106208463) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
![]() |
![]() |
Hgene | Tgene |
. | IGHG1 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for ACTR3-IGHG1 |
![]() |
Top |
Fusion Gene PPI Analysis for ACTR3-IGHG1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for ACTR3-IGHG1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | IGHG1 | P01857 | DB09130 | Copper | Small molecule | Approved|Investigational |
Top |
Related Diseases for ACTR3-IGHG1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACTR3 | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
Hgene | ACTR3 | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
Hgene | ACTR3 | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
Hgene | ACTR3 | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
Hgene | ACTR3 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Hgene | ACTR3 | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
Tgene | C0027121 | Myositis | 1 | CTD_human | |
Tgene | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human | |
Tgene | C0158353 | Infectious Myositis | 1 | CTD_human | |
Tgene | C0544796 | Myositis, Proliferative | 1 | CTD_human | |
Tgene | C0751356 | Idiopathic Inflammatory Myopathies | 1 | CTD_human | |
Tgene | C0751357 | Myositis, Focal | 1 | CTD_human | |
Tgene | C1136382 | Sclerocystic Ovaries | 1 | CTD_human |