Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:NOTCH2NL-PAN3 (FusionGDB2 ID:HG100996763TG255967)

Fusion Gene Summary for NOTCH2NL-PAN3

check button Fusion gene summary
Fusion gene informationFusion gene name: NOTCH2NL-PAN3
Fusion gene ID: hg100996763tg255967
HgeneTgene
Gene symbol

NOTCH2NL

PAN3

Gene ID

100996763

255967

Gene namenotch 2 N-terminal like Bpoly(A) specific ribonuclease subunit PAN3
SynonymsN2N|NOTCH2NL|NOTCH2NLA-
Cytomap('NOTCH2NL')('PAN3')

1q21.2

13q12.2

Type of geneprotein-codingprotein-coding
Descriptionnotch homolog 2 N-terminal-like protein BNotch homolog 2 N-terminal-like protein Anotch homolog 2 N-terminal-like proteinPAN2-PAN3 deadenylation complex subunit PAN3PAB-dependent poly(A)-specific ribonuclease subunit 3PAB-dependent poly(A)-specific ribonuclease subunit PAN3PAB1P-dependent poly(A)-nucleasePAB1P-dependent poly(A)-specific ribonucleasePABP-dependent poly(
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000344859, ENST00000362074, 
ENST00000369340, ENST00000479995, 
Fusion gene scores* DoF score23 X 4 X 14=128814 X 12 X 4=672
# samples 2214
** MAII scorelog2(22/1288*10)=-2.54955716458996
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/672*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOTCH2NL [Title/Abstract] AND PAN3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNOTCH2NL(145281704)-PAN3(28830428), # samples:1
Anticipated loss of major functional domain due to fusion event.NOTCH2NL-PAN3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NOTCH2NL-PAN3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NOTCH2NL-PAN3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NOTCH2NL-PAN3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNOTCH2NL

GO:0021987

cerebral cortex development

29561261|29856954|29856955

HgeneNOTCH2NL

GO:0045747

positive regulation of Notch signaling pathway

29856954|29856955


check buttonFusion gene breakpoints across NOTCH2NL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PAN3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-B7-A5TNNOTCH2NLchr1

145281704

+PAN3chr13

28830428

+


Top

Fusion Gene ORF analysis for NOTCH2NL-PAN3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000344859ENST00000483842NOTCH2NLchr1

145281704

+PAN3chr13

28830428

+
5CDS-3UTRENST00000362074ENST00000483842NOTCH2NLchr1

145281704

+PAN3chr13

28830428

+
5CDS-3UTRENST00000369340ENST00000483842NOTCH2NLchr1

145281704

+PAN3chr13

28830428

+
In-frameENST00000344859ENST00000282391NOTCH2NLchr1

145281704

+PAN3chr13

28830428

+
In-frameENST00000344859ENST00000380958NOTCH2NLchr1

145281704

+PAN3chr13

28830428

+
In-frameENST00000344859ENST00000399613NOTCH2NLchr1

145281704

+PAN3chr13

28830428

+
In-frameENST00000362074ENST00000282391NOTCH2NLchr1

145281704

+PAN3chr13

28830428

+
In-frameENST00000362074ENST00000380958NOTCH2NLchr1

145281704

+PAN3chr13

28830428

+
In-frameENST00000362074ENST00000399613NOTCH2NLchr1

145281704

+PAN3chr13

28830428

+
In-frameENST00000369340ENST00000282391NOTCH2NLchr1

145281704

+PAN3chr13

28830428

+
In-frameENST00000369340ENST00000380958NOTCH2NLchr1

145281704

+PAN3chr13

28830428

+
In-frameENST00000369340ENST00000399613NOTCH2NLchr1

145281704

+PAN3chr13

28830428

+
intron-3CDSENST00000479995ENST00000282391NOTCH2NLchr1

145281704

+PAN3chr13

28830428

+
intron-3CDSENST00000479995ENST00000380958NOTCH2NLchr1

145281704

+PAN3chr13

28830428

+
intron-3CDSENST00000479995ENST00000399613NOTCH2NLchr1

145281704

+PAN3chr13

28830428

+
intron-3UTRENST00000479995ENST00000483842NOTCH2NLchr1

145281704

+PAN3chr13

28830428

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000362074NOTCH2NLchr1145281704+ENST00000380958PAN3chr1328830428+26779961342659841
ENST00000362074NOTCH2NLchr1145281704+ENST00000399613PAN3chr1328830428+54739961342659841
ENST00000362074NOTCH2NLchr1145281704+ENST00000282391PAN3chr1328830428+54769961342659841
ENST00000344859NOTCH2NLchr1145281704+ENST00000380958PAN3chr1328830428+26779961342659841
ENST00000344859NOTCH2NLchr1145281704+ENST00000399613PAN3chr1328830428+54739961342659841
ENST00000344859NOTCH2NLchr1145281704+ENST00000282391PAN3chr1328830428+54769961342659841
ENST00000369340NOTCH2NLchr1145281704+ENST00000380958PAN3chr1328830428+275910784022741779
ENST00000369340NOTCH2NLchr1145281704+ENST00000399613PAN3chr1328830428+555510784022741779
ENST00000369340NOTCH2NLchr1145281704+ENST00000282391PAN3chr1328830428+555810784022741779

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000362074ENST00000380958NOTCH2NLchr1145281704+PAN3chr1328830428+0.0033734080.9966266
ENST00000362074ENST00000399613NOTCH2NLchr1145281704+PAN3chr1328830428+0.0007894210.9992106
ENST00000362074ENST00000282391NOTCH2NLchr1145281704+PAN3chr1328830428+0.0007907610.9992092
ENST00000344859ENST00000380958NOTCH2NLchr1145281704+PAN3chr1328830428+0.0033734080.9966266
ENST00000344859ENST00000399613NOTCH2NLchr1145281704+PAN3chr1328830428+0.0007894210.9992106
ENST00000344859ENST00000282391NOTCH2NLchr1145281704+PAN3chr1328830428+0.0007907610.9992092
ENST00000369340ENST00000380958NOTCH2NLchr1145281704+PAN3chr1328830428+0.0023835670.9976164
ENST00000369340ENST00000399613NOTCH2NLchr1145281704+PAN3chr1328830428+0.000703380.99929655
ENST00000369340ENST00000282391NOTCH2NLchr1145281704+PAN3chr1328830428+0.0007041360.99929583

Top

Fusion Genomic Features for NOTCH2NL-PAN3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NOTCH2NLchr1145281704+PAN3chr1328830428+0.000118080.99988186
NOTCH2NLchr1145281704+PAN3chr1328830428+0.000118080.99988186

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for NOTCH2NL-PAN3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:145281704/chr13:28830428)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOTCH2NLchr1:145281704chr13:28830428ENST00000344859+46105_141211416.3333333333333DomainEGF-like 4
HgeneNOTCH2NLchr1:145281704chr13:28830428ENST00000344859+46143_180211416.3333333333333DomainEGF-like 5%3B calcium-binding
HgeneNOTCH2NLchr1:145281704chr13:28830428ENST00000344859+461_24211416.3333333333333DomainEGF-like 1
HgeneNOTCH2NLchr1:145281704chr13:28830428ENST00000344859+4625_63211416.3333333333333DomainEGF-like 2
HgeneNOTCH2NLchr1:145281704chr13:28830428ENST00000344859+4666_104211416.3333333333333DomainEGF-like 3
HgeneNOTCH2NLchr1:145281704chr13:28830428ENST00000362074+45105_141211237.0DomainEGF-like 4
HgeneNOTCH2NLchr1:145281704chr13:28830428ENST00000362074+45143_180211237.0DomainEGF-like 5%3B calcium-binding
HgeneNOTCH2NLchr1:145281704chr13:28830428ENST00000362074+451_24211237.0DomainEGF-like 1
HgeneNOTCH2NLchr1:145281704chr13:28830428ENST00000362074+4525_63211237.0DomainEGF-like 2
HgeneNOTCH2NLchr1:145281704chr13:28830428ENST00000362074+4566_104211237.0DomainEGF-like 3
HgeneNOTCH2NLchr1:145281704chr13:28830428ENST00000369340+56105_141211237.0DomainEGF-like 4
HgeneNOTCH2NLchr1:145281704chr13:28830428ENST00000369340+56143_180211237.0DomainEGF-like 5%3B calcium-binding
HgeneNOTCH2NLchr1:145281704chr13:28830428ENST00000369340+561_24211237.0DomainEGF-like 1
HgeneNOTCH2NLchr1:145281704chr13:28830428ENST00000369340+5625_63211237.0DomainEGF-like 2
HgeneNOTCH2NLchr1:145281704chr13:28830428ENST00000369340+5666_104211237.0DomainEGF-like 3
TgenePAN3chr1:145281704chr13:28830428ENST00000282391014751_78921576.0Coiled coilOntology_term=ECO:0000255
TgenePAN3chr1:145281704chr13:28830428ENST00000380958519751_789333888.0Coiled coilOntology_term=ECO:0000255
TgenePAN3chr1:145281704chr13:28830428ENST00000399613418751_789133688.0Coiled coilOntology_term=ECO:0000255
TgenePAN3chr1:145281704chr13:28830428ENST00000282391014284_29921576.0MotifPABPC-interacting motif-2 (PAM-2)
TgenePAN3chr1:145281704chr13:28830428ENST00000399613418284_299133688.0MotifPABPC-interacting motif-2 (PAM-2)
TgenePAN3chr1:145281704chr13:28830428ENST00000282391014570_57721576.0Nucleotide bindingATP
TgenePAN3chr1:145281704chr13:28830428ENST00000282391014644_64521576.0Nucleotide bindingATP
TgenePAN3chr1:145281704chr13:28830428ENST00000380958519570_577333888.0Nucleotide bindingATP
TgenePAN3chr1:145281704chr13:28830428ENST00000380958519644_645333888.0Nucleotide bindingATP
TgenePAN3chr1:145281704chr13:28830428ENST00000399613418570_577133688.0Nucleotide bindingATP
TgenePAN3chr1:145281704chr13:28830428ENST00000399613418644_645133688.0Nucleotide bindingATP
TgenePAN3chr1:145281704chr13:28830428ENST00000282391014463_75021576.0RegionPseudokinase domain
TgenePAN3chr1:145281704chr13:28830428ENST00000282391014790_88721576.0RegionKnob domain
TgenePAN3chr1:145281704chr13:28830428ENST00000380958519463_750333888.0RegionPseudokinase domain
TgenePAN3chr1:145281704chr13:28830428ENST00000380958519790_887333888.0RegionKnob domain
TgenePAN3chr1:145281704chr13:28830428ENST00000399613418463_750133688.0RegionPseudokinase domain
TgenePAN3chr1:145281704chr13:28830428ENST00000399613418790_887133688.0RegionKnob domain
TgenePAN3chr1:145281704chr13:28830428ENST0000028239101443_7121576.0Zinc fingerC3H1-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOTCH2NLchr1:145281704chr13:28830428ENST00000344859+46182_219211416.3333333333333DomainEGF-like 6
HgeneNOTCH2NLchr1:145281704chr13:28830428ENST00000362074+45182_219211237.0DomainEGF-like 6
HgeneNOTCH2NLchr1:145281704chr13:28830428ENST00000369340+56182_219211237.0DomainEGF-like 6
TgenePAN3chr1:145281704chr13:28830428ENST00000380958519284_299333888.0MotifPABPC-interacting motif-2 (PAM-2)
TgenePAN3chr1:145281704chr13:28830428ENST0000038095851943_71333888.0Zinc fingerC3H1-type
TgenePAN3chr1:145281704chr13:28830428ENST0000039961341843_71133688.0Zinc fingerC3H1-type


Top

Fusion Gene Sequence for NOTCH2NL-PAN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59748_59748_1_NOTCH2NL-PAN3_NOTCH2NL_chr1_145281704_ENST00000344859_PAN3_chr13_28830428_ENST00000282391_length(transcript)=5476nt_BP=996nt
GCTGCACACCCGAGAAAGTTTCAGCCAAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAG
GCATTTGCGCTGGGCTTCGGAGCGTAGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGA
CCCCCTCCCCATGTGGATCTGCCCAGGCGGCGGCGGCGGCGGCGGCGGAGGAGGCGACCGAGAAGATACCCGCCCTGCGCCCCGCTCTGC
TGTGGGCGCTGCTGGCGCTCTGGCTGTGCTGCGCGACCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAG
GAATGTGTGTTACCTACCACAATGGCACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTG
AGAAGAACCGCTGCCAGAATGGTGGGACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAG
AGGACTGCCAGTACTCGACATCTCATCCATGCTTTGTGTCTCGACCTTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCT
ATGAGTGCACCTGTCAAGTCGGGTTTACAGGTAAGGAGTGCCAATGGACCGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCT
GTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAGTGTGAGACTGATGTCAATGAGTGTGACATTC
CAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCTTCAGGGCTTCACAGGCCAGTACTGTG
ACAGCCTGTATGTGCCCTGTGCACCCTCGCCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCC
TTCCAGGAATGTCGTTGTCTGCTGGGTCTTCCCCTCTTCATTCCCCCAAGATTACTCCACATACTTCTCCTGCTCCCAGAAGAAGAAGTC
ACACTCCAAATCCAGCAAGTTACATGGTGCCTTCTAGTGCCTCTACATCTGTTAATAATCCTGTTTCTCAGACTCCGTCTTCTGGTCAGG
TGATCCAAAAGGAAACTGTTGGTGGGACGACTTACTTCTATACAGACACAACTCCAGCACCTTTGACTGGAATGGTGTTTCCAAACTATC
ATATTTATCCTCCAACTGCACCTCACGTTGCTTATATGCAACCGAAAGCAAACGCACCTTCCTTCTTCATGGCTGATGAACTCCGACAGG
AGCTGATCAACAGACATTTAATAACAATGGCTCAAATTGATCAAGCAGATATGCCAGCAGTTCCTACAGAGGTTGACAGCTACCATAGCC
TATTCCCTCTAGAACCACTGCCACCTCCCAACCGGATACAGAAATCAAGTAATTTTGGATATATTACATCTTGCTACAAAGCTGTAAACA
GCAAAGATGATCTGCCATATTGCCTTCGGAGGATACATGGTTTTCGTCTTGTTAACACAAAGTGCATGGTGTTGGTCGACATGTGGAAGA
AAATTCAACACTCAAATATCGTAACTTTGCGTGAAGTATTTACCACTAAAGCATTTGCTGAGCCCTCTCTTGTGTTTGCATATGATTTCC
ATGCTGGAGGAGAAACTATGATGAGCAGACACTTTAATGACCCTAATGCTGATGCCTACTTCACCAAGAGAAAGTGGGGTCAGCACGAGG
GACCATTGCCCAGGCAGCATGCTGGATTATTGCCAGAATCTCTTATTTGGGCATATATTGTCCAACTAAGTTCTGCATTGCGTACCATTC
ATACAGCAGGTTTGGCATGTCGAGTTATGGATCCAACAAAGATTCTGATAACTGGCAAAACAAGGTTGCGAGTAAATTGTGTTGGAGTTT
TTGATGTTTTAACATTTGATAACAGTCAAAATAATAATCCATTGGCATTAATGGCCCAGTACCAGCAAGCAGATCTGATATCATTAGGAA
AAGTTGTGTTGGCTTTGGCTTGCAACTCTTTGGCAGGAATTCAGCGAGAGAATTTACAGAAAGCCATGGAACTGGTGACAATCAACTATT
CCTCTGACCTGAAGAATCTGATTTTGTATTTGTTGACTGACCAAAACAGGATGCGAAGTGTAAATGACATCATGCCCATGATTGGTGCTC
GATTTTATACTCAATTGGATGCTGCTCAAATGAGAAATGATGTCATAGAGGAAGACCTTGCAAAGGAGGTTCAAAATGGAAGACTGTTTA
GGCTCCTAGCAAAATTGGGAACAATCAATGAGAGGCCGGAGTTTCAGAAGGATCCCACTTGGTCAGAGACTGGAGACCGTTATCTGTTGA
AACTCTTTAGGGATCATCTTTTTCATCAGGTGACAGAAGCAGGTGCTCCCTGGATTGACCTCAGTCATATAATTTCTTGTCTTAACAAGC
TAGATGCTGGTGTGCCAGAAAAAATAAGCCTGATTTCCAGAGATGAGAAGAGTGTACTTGTGGTGACCTACAGTGACTTAAAGCGCTGCT
TTGAAAATACTTTTCAAGAACTGATTGCAGCTGCAAATGGTCAGTTGTAGTATTTGCTAAAAAAGCACGCAGGACATGGCTAAAGACCTT
AACCAATAGCAAATTGCACTACAGCTGAACTTTTCATCATCTCATTCACATTTGGGAAACGAACAGGAGATGAGCAAAGCTGCTTGCACT
TCAGTCAGGTACACTGTTACTTGAAAGGAAGAATGTTTCACTTACCCAAGAGCTATGGCTGCCATTGGAGGCTGTTATCTGTGAAGAATT
TATTTTAGATTTAGGAGCACCATCAGGTGAATGATGTTCCTGCTTTTGTTTTTTCCACTTGTATATGCACTAATTTTAATTTTTTAAAGA
CTTTTTCTGATCTTTGAACTTTTGCCACATTGTATACTTATAATGGGAAACTTTGCAAGGACATTTTTGGGAAGCAATGCTGGGCAGCGT
TTTTGCCATTGAGGGTTGCAGAATTTGCTCTTTTTGGGATGGGTTGCCCTGAATAACATTACGGACCAGGTAAATAATTTCATAGAAGTT
CAGTATAGTACGTAATTCTTGTAAGAGTATCGTATGCAAGCTCTCTGTATGCCACCCACTGTTAGTTCAAATTGAGATTTTTGTTTTGTT
TTGTTCTTAAGAACATACCAAGAAAATACCAGTGAATTGTTGGATATGAATTCCCTGTTAGTTGATTTAAATCCTTTCTGAATAAAGATC
AGATAAACAGTAACTGAAGGAGCATGTATAGCTCTTTCCTTCAAATTCAACTAGAGCCTTTTTAAAAAGACATTTGCCTGCTAGTCAGAT
ACATTTACATTTATGCAAATTTTTTAAATAGGAGAAAATTAAGAAATTGTGTTAAAGGCCTAAAGTTCAGGAGTGTATTACTTTAGGTTC
TTTCCAGTTTGCTGGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGGCGGGGGGGAGGTTTATGAAGTTTTGCTCTTTGAACCACAGCTT
TATTATGGTCCTTTACACTGGAGACAGACACAGAGACACTGTTCAGAAGATGAACTAAACTCAGCAGTGGTCTGGTATCAAGAGCTTTCT
GATGTTTTACAGCCTGAATTTGGAGGGATAACGATCTGCTGTGCCTTTGCAGTCACTGCTTAGCCCAAAGTAATAGTACTTTTGATAATA
ACTCACTCTGTGCGATATTCCTGAATAAGTCCATCTCAAAAGTTTGGGATTTTCCTCCTCTTAACTTTCTTAATATTTGGACATGCAGTT
GTCGCCAAACTTGGGTATTCATGGAATTTCTAGTAAATGAAATACCTATACTTTGATACTGAAGACTGCCAAATACATAGGAATTTTCTT
TCTTAAAAAACAGTAATGAAGACTATATCTCCTTTCCCAGCACTGAATGTTTTACTAGCACTGGGTGCTCACCATGCAACTGAAGAAAAT
GTGGAAACTCAAAAGGTCAGGACAGACTTCCAAGCACTTGCAACTGATGTTACTGTCTTCAATTTTAATAATTACACATATTTGTATATT
TCAGAGAAGTTTTTAATATTTCTCTGTCCACTTTTTATAAGCTTTAAAATGATTTTCTCTGCCTTGAGATTTGCATCAAGAAAAAGCACC
TCTCTTCACCTGAAAGCTTTGAAGACTAGAGACACGCTTTACACGTTTTAACAAGTATATTGAGTCCACGTTTGGTAGCATCAGTTGTTG
AGTTAAAAAGAAAATTATTGCATTTGATCTGGATGGATTTTAAAAGAATATAATGTTCAATATTAAAAGGATAATTCACATTTGCCACCA
TAATGTTCTTTTTTATGTAAAAAGAAGAACTTGGAGACATTAACATGAAAAAGTCTTTTATCATTAGCTCATGTATTTGAGGAAGAGCAG
CTGTCTTTTTATATGTTTTTTGACAAATCATATTGTATTCTTTTGTACAAAAAAGAACTACTTGTATTCTAGAAGAAATATGAAATGCTT
AATTTATAAGCGGGCTGGAGATTTTTTCCAATATTGTTTTCTTTGAAAATGAAAGGGGATCATCTATTTTAGTTTTGGGGTCTGGGAACT
TTTTGAAAATTTAATTTGTGGACCAATGTTTTGTGAAAGCTAAAGAGGGCAGGGGTTAAAATAGGGCTTGAATTTCTCATTCTGTATAGA
CCAGCAAACTTCCCTGTGCAAGGCAAGTTTACATCACAAATCCAAGAATGTTTGCATCCTAAATGCTAGTTTGCTTCAGCCCCTAGTTAA
CCTCAGGACTTGGTTTGCATATAAAAGGTAGACAGCTGATATGTTTTCATGAATAAATATTGTCAGCCAGAAAAGGTTGGTGTCAGGTAA
TGCATATTTTTTTAAGCTTTGTTTTATATTTATTTTTCATTTAGTTTTTATTGGGAATGGTTTTCAAAGAACTCTCAGTTCTGCCTAGGT
GTTTTTGGGGGAGCCCTGTTTTCCATAGTGTAATTCCATTTAAGAGGTTGTCTAAAAGTCTTTTTAATTAATAGAAAGATTTTAATATCC
AAGAGTAGTCAAATTAAGGATATAAACTTTCCACACCTTCCTGTCGTGACAGATAAAAGCACAGAAAGGACAACCCTTGAAATCATGTAA
CGTTGGTCATTTCAATATTTTGTACCTGTTTTAAATTCTGTTAGTGTATTTACTTCATTGTAAATATTTTTGAGGGTACCTTTGTATTTT
GCTTTTGACCTTGGTTCTGTGATTTGGATGTCAACAACTTCCCTAAAAAGCACCAGTGTGTTAGGTTCTAATGTCATGACCCAATTTGTG
TTATTCATCTTTAATCCTGTTTTCAGTCTCTATGTGTACAGCAGTATTTTTAATAAAGAATTACAGAGATAAATTT

>59748_59748_1_NOTCH2NL-PAN3_NOTCH2NL_chr1_145281704_ENST00000344859_PAN3_chr13_28830428_ENST00000282391_length(amino acids)=841AA_BP=287
MKQEEGRREWGSSIGTPSPCGSAQAAAAAAAEEATEKIPALRPALLWALLALWLCCATPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKC
PEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ
WTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNG
GTCRQTGDFTFECNCLPGMSLSAGSSPLHSPKITPHTSPAPRRRSHTPNPASYMVPSSASTSVNNPVSQTPSSGQVIQKETVGGTTYFYT
DTTPAPLTGMVFPNYHIYPPTAPHVAYMQPKANAPSFFMADELRQELINRHLITMAQIDQADMPAVPTEVDSYHSLFPLEPLPPPNRIQK
SSNFGYITSCYKAVNSKDDLPYCLRRIHGFRLVNTKCMVLVDMWKKIQHSNIVTLREVFTTKAFAEPSLVFAYDFHAGGETMMSRHFNDP
NADAYFTKRKWGQHEGPLPRQHAGLLPESLIWAYIVQLSSALRTIHTAGLACRVMDPTKILITGKTRLRVNCVGVFDVLTFDNSQNNNPL
ALMAQYQQADLISLGKVVLALACNSLAGIQRENLQKAMELVTINYSSDLKNLILYLLTDQNRMRSVNDIMPMIGARFYTQLDAAQMRNDV
IEEDLAKEVQNGRLFRLLAKLGTINERPEFQKDPTWSETGDRYLLKLFRDHLFHQVTEAGAPWIDLSHIISCLNKLDAGVPEKISLISRD
EKSVLVVTYSDLKRCFENTFQELIAAANGQL

--------------------------------------------------------------
>59748_59748_2_NOTCH2NL-PAN3_NOTCH2NL_chr1_145281704_ENST00000344859_PAN3_chr13_28830428_ENST00000380958_length(transcript)=2677nt_BP=996nt
GCTGCACACCCGAGAAAGTTTCAGCCAAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAG
GCATTTGCGCTGGGCTTCGGAGCGTAGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGA
CCCCCTCCCCATGTGGATCTGCCCAGGCGGCGGCGGCGGCGGCGGCGGAGGAGGCGACCGAGAAGATACCCGCCCTGCGCCCCGCTCTGC
TGTGGGCGCTGCTGGCGCTCTGGCTGTGCTGCGCGACCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAG
GAATGTGTGTTACCTACCACAATGGCACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTG
AGAAGAACCGCTGCCAGAATGGTGGGACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAG
AGGACTGCCAGTACTCGACATCTCATCCATGCTTTGTGTCTCGACCTTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCT
ATGAGTGCACCTGTCAAGTCGGGTTTACAGGTAAGGAGTGCCAATGGACCGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCT
GTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAGTGTGAGACTGATGTCAATGAGTGTGACATTC
CAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCTTCAGGGCTTCACAGGCCAGTACTGTG
ACAGCCTGTATGTGCCCTGTGCACCCTCGCCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCC
TTCCAGGAATGTCGTTGTCTGCTGGGTCTTCCCCTCTTCATTCCCCCAAGATTACTCCACATACTTCTCCTGCTCCCAGAAGAAGAAGTC
ACACTCCAAATCCAGCAAGTTACATGGTGCCTTCTAGTGCCTCTACATCTGTTAATAATCCTGTTTCTCAGACTCCGTCTTCTGGTCAGG
TGATCCAAAAGGAAACTGTTGGTGGGACGACTTACTTCTATACAGACACAACTCCAGCACCTTTGACTGGAATGGTGTTTCCAAACTATC
ATATTTATCCTCCAACTGCACCTCACGTTGCTTATATGCAACCGAAAGCAAACGCACCTTCCTTCTTCATGGCTGATGAACTCCGACAGG
AGCTGATCAACAGACATTTAATAACAATGGCTCAAATTGATCAAGCAGATATGCCAGCAGTTCCTACAGAGGTTGACAGCTACCATAGCC
TATTCCCTCTAGAACCACTGCCACCTCCCAACCGGATACAGAAATCAAGTAATTTTGGATATATTACATCTTGCTACAAAGCTGTAAACA
GCAAAGATGATCTGCCATATTGCCTTCGGAGGATACATGGTTTTCGTCTTGTTAACACAAAGTGCATGGTGTTGGTCGACATGTGGAAGA
AAATTCAACACTCAAATATCGTAACTTTGCGTGAAGTATTTACCACTAAAGCATTTGCTGAGCCCTCTCTTGTGTTTGCATATGATTTCC
ATGCTGGAGGAGAAACTATGATGAGCAGACACTTTAATGACCCTAATGCTGATGCCTACTTCACCAAGAGAAAGTGGGGTCAGCACGAGG
GACCATTGCCCAGGCAGCATGCTGGATTATTGCCAGAATCTCTTATTTGGGCATATATTGTCCAACTAAGTTCTGCATTGCGTACCATTC
ATACAGCAGGTTTGGCATGTCGAGTTATGGATCCAACAAAGATTCTGATAACTGGCAAAACAAGGTTGCGAGTAAATTGTGTTGGAGTTT
TTGATGTTTTAACATTTGATAACAGTCAAAATAATAATCCATTGGCATTAATGGCCCAGTACCAGCAAGCAGATCTGATATCATTAGGAA
AAGTTGTGTTGGCTTTGGCTTGCAACTCTTTGGCAGGAATTCAGCGAGAGAATTTACAGAAAGCCATGGAACTGGTGACAATCAACTATT
CCTCTGACCTGAAGAATCTGATTTTGTATTTGTTGACTGACCAAAACAGGATGCGAAGTGTAAATGACATCATGCCCATGATTGGTGCTC
GATTTTATACTCAATTGGATGCTGCTCAAATGAGAAATGATGTCATAGAGGAAGACCTTGCAAAGGAGGTTCAAAATGGAAGACTGTTTA
GGCTCCTAGCAAAATTGGGAACAATCAATGAGAGGCCGGAGTTTCAGAAGGATCCCACTTGGTCAGAGACTGGAGACCGTTATCTGTTGA
AACTCTTTAGGGATCATCTTTTTCATCAGGTGACAGAAGCAGGTGCTCCCTGGATTGACCTCAGTCATATAATTTCTTGTCTTAACAAGC
TAGATGCTGGTGTGCCAGAAAAAATAAGCCTGATTTCCAGAGATGAGAAGAGTGTACTTGTGGTGACCTACAGTGACTTAAAGCGCTGCT
TTGAAAATACTTTTCAAGAACTGATTGCAGCTGCAAATGGTCAGTTGTAGTATTTGCTAAAAAAGCA

>59748_59748_2_NOTCH2NL-PAN3_NOTCH2NL_chr1_145281704_ENST00000344859_PAN3_chr13_28830428_ENST00000380958_length(amino acids)=841AA_BP=287
MKQEEGRREWGSSIGTPSPCGSAQAAAAAAAEEATEKIPALRPALLWALLALWLCCATPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKC
PEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ
WTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNG
GTCRQTGDFTFECNCLPGMSLSAGSSPLHSPKITPHTSPAPRRRSHTPNPASYMVPSSASTSVNNPVSQTPSSGQVIQKETVGGTTYFYT
DTTPAPLTGMVFPNYHIYPPTAPHVAYMQPKANAPSFFMADELRQELINRHLITMAQIDQADMPAVPTEVDSYHSLFPLEPLPPPNRIQK
SSNFGYITSCYKAVNSKDDLPYCLRRIHGFRLVNTKCMVLVDMWKKIQHSNIVTLREVFTTKAFAEPSLVFAYDFHAGGETMMSRHFNDP
NADAYFTKRKWGQHEGPLPRQHAGLLPESLIWAYIVQLSSALRTIHTAGLACRVMDPTKILITGKTRLRVNCVGVFDVLTFDNSQNNNPL
ALMAQYQQADLISLGKVVLALACNSLAGIQRENLQKAMELVTINYSSDLKNLILYLLTDQNRMRSVNDIMPMIGARFYTQLDAAQMRNDV
IEEDLAKEVQNGRLFRLLAKLGTINERPEFQKDPTWSETGDRYLLKLFRDHLFHQVTEAGAPWIDLSHIISCLNKLDAGVPEKISLISRD
EKSVLVVTYSDLKRCFENTFQELIAAANGQL

--------------------------------------------------------------
>59748_59748_3_NOTCH2NL-PAN3_NOTCH2NL_chr1_145281704_ENST00000344859_PAN3_chr13_28830428_ENST00000399613_length(transcript)=5473nt_BP=996nt
GCTGCACACCCGAGAAAGTTTCAGCCAAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAG
GCATTTGCGCTGGGCTTCGGAGCGTAGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGA
CCCCCTCCCCATGTGGATCTGCCCAGGCGGCGGCGGCGGCGGCGGCGGAGGAGGCGACCGAGAAGATACCCGCCCTGCGCCCCGCTCTGC
TGTGGGCGCTGCTGGCGCTCTGGCTGTGCTGCGCGACCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAG
GAATGTGTGTTACCTACCACAATGGCACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTG
AGAAGAACCGCTGCCAGAATGGTGGGACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAG
AGGACTGCCAGTACTCGACATCTCATCCATGCTTTGTGTCTCGACCTTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCT
ATGAGTGCACCTGTCAAGTCGGGTTTACAGGTAAGGAGTGCCAATGGACCGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCT
GTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAGTGTGAGACTGATGTCAATGAGTGTGACATTC
CAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCTTCAGGGCTTCACAGGCCAGTACTGTG
ACAGCCTGTATGTGCCCTGTGCACCCTCGCCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCC
TTCCAGGAATGTCGTTGTCTGCTGGGTCTTCCCCTCTTCATTCCCCCAAGATTACTCCACATACTTCTCCTGCTCCCAGAAGAAGAAGTC
ACACTCCAAATCCAGCAAGTTACATGGTGCCTTCTAGTGCCTCTACATCTGTTAATAATCCTGTTTCTCAGACTCCGTCTTCTGGTCAGG
TGATCCAAAAGGAAACTGTTGGTGGGACGACTTACTTCTATACAGACACAACTCCAGCACCTTTGACTGGAATGGTGTTTCCAAACTATC
ATATTTATCCTCCAACTGCACCTCACGTTGCTTATATGCAACCGAAAGCAAACGCACCTTCCTTCTTCATGGCTGATGAACTCCGACAGG
AGCTGATCAACAGACATTTAATAACAATGGCTCAAATTGATCAAGCAGATATGCCAGCAGTTCCTACAGAGGTTGACAGCTACCATAGCC
TATTCCCTCTAGAACCACTGCCACCTCCCAACCGGATACAGAAATCAAGTAATTTTGGATATATTACATCTTGCTACAAAGCTGTAAACA
GCAAAGATGATCTGCCATATTGCCTTCGGAGGATACATGGTTTTCGTCTTGTTAACACAAAGTGCATGGTGTTGGTCGACATGTGGAAGA
AAATTCAACACTCAAATATCGTAACTTTGCGTGAAGTATTTACCACTAAAGCATTTGCTGAGCCCTCTCTTGTGTTTGCATATGATTTCC
ATGCTGGAGGAGAAACTATGATGAGCAGACACTTTAATGACCCTAATGCTGATGCCTACTTCACCAAGAGAAAGTGGGGTCAGCACGAGG
GACCATTGCCCAGGCAGCATGCTGGATTATTGCCAGAATCTCTTATTTGGGCATATATTGTCCAACTAAGTTCTGCATTGCGTACCATTC
ATACAGCAGGTTTGGCATGTCGAGTTATGGATCCAACAAAGATTCTGATAACTGGCAAAACAAGGTTGCGAGTAAATTGTGTTGGAGTTT
TTGATGTTTTAACATTTGATAACAGTCAAAATAATAATCCATTGGCATTAATGGCCCAGTACCAGCAAGCAGATCTGATATCATTAGGAA
AAGTTGTGTTGGCTTTGGCTTGCAACTCTTTGGCAGGAATTCAGCGAGAGAATTTACAGAAAGCCATGGAACTGGTGACAATCAACTATT
CCTCTGACCTGAAGAATCTGATTTTGTATTTGTTGACTGACCAAAACAGGATGCGAAGTGTAAATGACATCATGCCCATGATTGGTGCTC
GATTTTATACTCAATTGGATGCTGCTCAAATGAGAAATGATGTCATAGAGGAAGACCTTGCAAAGGAGGTTCAAAATGGAAGACTGTTTA
GGCTCCTAGCAAAATTGGGAACAATCAATGAGAGGCCGGAGTTTCAGAAGGATCCCACTTGGTCAGAGACTGGAGACCGTTATCTGTTGA
AACTCTTTAGGGATCATCTTTTTCATCAGGTGACAGAAGCAGGTGCTCCCTGGATTGACCTCAGTCATATAATTTCTTGTCTTAACAAGC
TAGATGCTGGTGTGCCAGAAAAAATAAGCCTGATTTCCAGAGATGAGAAGAGTGTACTTGTGGTGACCTACAGTGACTTAAAGCGCTGCT
TTGAAAATACTTTTCAAGAACTGATTGCAGCTGCAAATGGTCAGTTGTAGTATTTGCTAAAAAAGCACGCAGGACATGGCTAAAGACCTT
AACCAATAGCAAATTGCACTACAGCTGAACTTTTCATCATCTCATTCACATTTGGGAAACGAACAGGAGATGAGCAAAGCTGCTTGCACT
TCAGTCAGGTACACTGTTACTTGAAAGGAAGAATGTTTCACTTACCCAAGAGCTATGGCTGCCATTGGAGGCTGTTATCTGTGAAGAATT
TATTTTAGATTTAGGAGCACCATCAGGTGAATGATGTTCCTGCTTTTGTTTTTTCCACTTGTATATGCACTAATTTTAATTTTTTAAAGA
CTTTTTCTGATCTTTGAACTTTTGCCACATTGTATACTTATAATGGGAAACTTTGCAAGGACATTTTTGGGAAGCAATGCTGGGCAGCGT
TTTTGCCATTGAGGGTTGCAGAATTTGCTCTTTTTGGGATGGGTTGCCCTGAATAACATTACGGACCAGGTAAATAATTTCATAGAAGTT
CAGTATAGTACGTAATTCTTGTAAGAGTATCGTATGCAAGCTCTCTGTATGCCACCCACTGTTAGTTCAAATTGAGATTTTTGTTTTGTT
TTGTTCTTAAGAACATACCAAGAAAATACCAGTGAATTGTTGGATATGAATTCCCTGTTAGTTGATTTAAATCCTTTCTGAATAAAGATC
AGATAAACAGTAACTGAAGGAGCATGTATAGCTCTTTCCTTCAAATTCAACTAGAGCCTTTTTAAAAAGACATTTGCCTGCTAGTCAGAT
ACATTTACATTTATGCAAATTTTTTAAATAGGAGAAAATTAAGAAATTGTGTTAAAGGCCTAAAGTTCAGGAGTGTATTACTTTAGGTTC
TTTCCAGTTTGCTGGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGGCGGGGGGGAGGTTTATGAAGTTTTGCTCTTTGAACCACAGCTT
TATTATGGTCCTTTACACTGGAGACAGACACAGAGACACTGTTCAGAAGATGAACTAAACTCAGCAGTGGTCTGGTATCAAGAGCTTTCT
GATGTTTTACAGCCTGAATTTGGAGGGATAACGATCTGCTGTGCCTTTGCAGTCACTGCTTAGCCCAAAGTAATAGTACTTTTGATAATA
ACTCACTCTGTGCGATATTCCTGAATAAGTCCATCTCAAAAGTTTGGGATTTTCCTCCTCTTAACTTTCTTAATATTTGGACATGCAGTT
GTCGCCAAACTTGGGTATTCATGGAATTTCTAGTAAATGAAATACCTATACTTTGATACTGAAGACTGCCAAATACATAGGAATTTTCTT
TCTTAAAAAACAGTAATGAAGACTATATCTCCTTTCCCAGCACTGAATGTTTTACTAGCACTGGGTGCTCACCATGCAACTGAAGAAAAT
GTGGAAACTCAAAAGGTCAGGACAGACTTCCAAGCACTTGCAACTGATGTTACTGTCTTCAATTTTAATAATTACACATATTTGTATATT
TCAGAGAAGTTTTTAATATTTCTCTGTCCACTTTTTATAAGCTTTAAAATGATTTTCTCTGCCTTGAGATTTGCATCAAGAAAAAGCACC
TCTCTTCACCTGAAAGCTTTGAAGACTAGAGACACGCTTTACACGTTTTAACAAGTATATTGAGTCCACGTTTGGTAGCATCAGTTGTTG
AGTTAAAAAGAAAATTATTGCATTTGATCTGGATGGATTTTAAAAGAATATAATGTTCAATATTAAAAGGATAATTCACATTTGCCACCA
TAATGTTCTTTTTTATGTAAAAAGAAGAACTTGGAGACATTAACATGAAAAAGTCTTTTATCATTAGCTCATGTATTTGAGGAAGAGCAG
CTGTCTTTTTATATGTTTTTTGACAAATCATATTGTATTCTTTTGTACAAAAAAGAACTACTTGTATTCTAGAAGAAATATGAAATGCTT
AATTTATAAGCGGGCTGGAGATTTTTTCCAATATTGTTTTCTTTGAAAATGAAAGGGGATCATCTATTTTAGTTTTGGGGTCTGGGAACT
TTTTGAAAATTTAATTTGTGGACCAATGTTTTGTGAAAGCTAAAGAGGGCAGGGGTTAAAATAGGGCTTGAATTTCTCATTCTGTATAGA
CCAGCAAACTTCCCTGTGCAAGGCAAGTTTACATCACAAATCCAAGAATGTTTGCATCCTAAATGCTAGTTTGCTTCAGCCCCTAGTTAA
CCTCAGGACTTGGTTTGCATATAAAAGGTAGACAGCTGATATGTTTTCATGAATAAATATTGTCAGCCAGAAAAGGTTGGTGTCAGGTAA
TGCATATTTTTTTAAGCTTTGTTTTATATTTATTTTTCATTTAGTTTTTATTGGGAATGGTTTTCAAAGAACTCTCAGTTCTGCCTAGGT
GTTTTTGGGGGAGCCCTGTTTTCCATAGTGTAATTCCATTTAAGAGGTTGTCTAAAAGTCTTTTTAATTAATAGAAAGATTTTAATATCC
AAGAGTAGTCAAATTAAGGATATAAACTTTCCACACCTTCCTGTCGTGACAGATAAAAGCACAGAAAGGACAACCCTTGAAATCATGTAA
CGTTGGTCATTTCAATATTTTGTACCTGTTTTAAATTCTGTTAGTGTATTTACTTCATTGTAAATATTTTTGAGGGTACCTTTGTATTTT
GCTTTTGACCTTGGTTCTGTGATTTGGATGTCAACAACTTCCCTAAAAAGCACCAGTGTGTTAGGTTCTAATGTCATGACCCAATTTGTG
TTATTCATCTTTAATCCTGTTTTCAGTCTCTATGTGTACAGCAGTATTTTTAATAAAGAATTACAGAGATAAA

>59748_59748_3_NOTCH2NL-PAN3_NOTCH2NL_chr1_145281704_ENST00000344859_PAN3_chr13_28830428_ENST00000399613_length(amino acids)=841AA_BP=287
MKQEEGRREWGSSIGTPSPCGSAQAAAAAAAEEATEKIPALRPALLWALLALWLCCATPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKC
PEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ
WTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNG
GTCRQTGDFTFECNCLPGMSLSAGSSPLHSPKITPHTSPAPRRRSHTPNPASYMVPSSASTSVNNPVSQTPSSGQVIQKETVGGTTYFYT
DTTPAPLTGMVFPNYHIYPPTAPHVAYMQPKANAPSFFMADELRQELINRHLITMAQIDQADMPAVPTEVDSYHSLFPLEPLPPPNRIQK
SSNFGYITSCYKAVNSKDDLPYCLRRIHGFRLVNTKCMVLVDMWKKIQHSNIVTLREVFTTKAFAEPSLVFAYDFHAGGETMMSRHFNDP
NADAYFTKRKWGQHEGPLPRQHAGLLPESLIWAYIVQLSSALRTIHTAGLACRVMDPTKILITGKTRLRVNCVGVFDVLTFDNSQNNNPL
ALMAQYQQADLISLGKVVLALACNSLAGIQRENLQKAMELVTINYSSDLKNLILYLLTDQNRMRSVNDIMPMIGARFYTQLDAAQMRNDV
IEEDLAKEVQNGRLFRLLAKLGTINERPEFQKDPTWSETGDRYLLKLFRDHLFHQVTEAGAPWIDLSHIISCLNKLDAGVPEKISLISRD
EKSVLVVTYSDLKRCFENTFQELIAAANGQL

--------------------------------------------------------------
>59748_59748_4_NOTCH2NL-PAN3_NOTCH2NL_chr1_145281704_ENST00000362074_PAN3_chr13_28830428_ENST00000282391_length(transcript)=5476nt_BP=996nt
GCTGCACACCCGAGAAAGTTTCAGCCAAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAG
GCATTTGCGCTGGGCTTCGGAGCGTAGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGA
CCCCCTCCCCATGTGGATCTGCCCAGGCGGCGGCGGCGGCGGCGGCGGAGGAGGCGACCGAGAAGATACCCGCCCTGCGCCCCGCTCTGC
TGTGGGCGCTGCTGGCGCTCTGGCTGTGCTGCGCGACCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAG
GAATGTGTGTTACCTACCACAATGGCACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTG
AGAAGAACCGCTGCCAGAATGGTGGGACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAG
AGGACTGCCAGTACTCGACATCTCATCCATGCTTTGTGTCTCGACCTTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCT
ATGAGTGCACCTGTCAAGTCGGGTTTACAGGTAAGGAGTGCCAATGGACCGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCT
GTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAGTGTGAGACTGATGTCAATGAGTGTGACATTC
CAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCTTCAGGGCTTCACAGGCCAGTACTGTG
ACAGCCTGTATGTGCCCTGTGCACCCTCGCCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCC
TTCCAGGAATGTCGTTGTCTGCTGGGTCTTCCCCTCTTCATTCCCCCAAGATTACTCCACATACTTCTCCTGCTCCCAGAAGAAGAAGTC
ACACTCCAAATCCAGCAAGTTACATGGTGCCTTCTAGTGCCTCTACATCTGTTAATAATCCTGTTTCTCAGACTCCGTCTTCTGGTCAGG
TGATCCAAAAGGAAACTGTTGGTGGGACGACTTACTTCTATACAGACACAACTCCAGCACCTTTGACTGGAATGGTGTTTCCAAACTATC
ATATTTATCCTCCAACTGCACCTCACGTTGCTTATATGCAACCGAAAGCAAACGCACCTTCCTTCTTCATGGCTGATGAACTCCGACAGG
AGCTGATCAACAGACATTTAATAACAATGGCTCAAATTGATCAAGCAGATATGCCAGCAGTTCCTACAGAGGTTGACAGCTACCATAGCC
TATTCCCTCTAGAACCACTGCCACCTCCCAACCGGATACAGAAATCAAGTAATTTTGGATATATTACATCTTGCTACAAAGCTGTAAACA
GCAAAGATGATCTGCCATATTGCCTTCGGAGGATACATGGTTTTCGTCTTGTTAACACAAAGTGCATGGTGTTGGTCGACATGTGGAAGA
AAATTCAACACTCAAATATCGTAACTTTGCGTGAAGTATTTACCACTAAAGCATTTGCTGAGCCCTCTCTTGTGTTTGCATATGATTTCC
ATGCTGGAGGAGAAACTATGATGAGCAGACACTTTAATGACCCTAATGCTGATGCCTACTTCACCAAGAGAAAGTGGGGTCAGCACGAGG
GACCATTGCCCAGGCAGCATGCTGGATTATTGCCAGAATCTCTTATTTGGGCATATATTGTCCAACTAAGTTCTGCATTGCGTACCATTC
ATACAGCAGGTTTGGCATGTCGAGTTATGGATCCAACAAAGATTCTGATAACTGGCAAAACAAGGTTGCGAGTAAATTGTGTTGGAGTTT
TTGATGTTTTAACATTTGATAACAGTCAAAATAATAATCCATTGGCATTAATGGCCCAGTACCAGCAAGCAGATCTGATATCATTAGGAA
AAGTTGTGTTGGCTTTGGCTTGCAACTCTTTGGCAGGAATTCAGCGAGAGAATTTACAGAAAGCCATGGAACTGGTGACAATCAACTATT
CCTCTGACCTGAAGAATCTGATTTTGTATTTGTTGACTGACCAAAACAGGATGCGAAGTGTAAATGACATCATGCCCATGATTGGTGCTC
GATTTTATACTCAATTGGATGCTGCTCAAATGAGAAATGATGTCATAGAGGAAGACCTTGCAAAGGAGGTTCAAAATGGAAGACTGTTTA
GGCTCCTAGCAAAATTGGGAACAATCAATGAGAGGCCGGAGTTTCAGAAGGATCCCACTTGGTCAGAGACTGGAGACCGTTATCTGTTGA
AACTCTTTAGGGATCATCTTTTTCATCAGGTGACAGAAGCAGGTGCTCCCTGGATTGACCTCAGTCATATAATTTCTTGTCTTAACAAGC
TAGATGCTGGTGTGCCAGAAAAAATAAGCCTGATTTCCAGAGATGAGAAGAGTGTACTTGTGGTGACCTACAGTGACTTAAAGCGCTGCT
TTGAAAATACTTTTCAAGAACTGATTGCAGCTGCAAATGGTCAGTTGTAGTATTTGCTAAAAAAGCACGCAGGACATGGCTAAAGACCTT
AACCAATAGCAAATTGCACTACAGCTGAACTTTTCATCATCTCATTCACATTTGGGAAACGAACAGGAGATGAGCAAAGCTGCTTGCACT
TCAGTCAGGTACACTGTTACTTGAAAGGAAGAATGTTTCACTTACCCAAGAGCTATGGCTGCCATTGGAGGCTGTTATCTGTGAAGAATT
TATTTTAGATTTAGGAGCACCATCAGGTGAATGATGTTCCTGCTTTTGTTTTTTCCACTTGTATATGCACTAATTTTAATTTTTTAAAGA
CTTTTTCTGATCTTTGAACTTTTGCCACATTGTATACTTATAATGGGAAACTTTGCAAGGACATTTTTGGGAAGCAATGCTGGGCAGCGT
TTTTGCCATTGAGGGTTGCAGAATTTGCTCTTTTTGGGATGGGTTGCCCTGAATAACATTACGGACCAGGTAAATAATTTCATAGAAGTT
CAGTATAGTACGTAATTCTTGTAAGAGTATCGTATGCAAGCTCTCTGTATGCCACCCACTGTTAGTTCAAATTGAGATTTTTGTTTTGTT
TTGTTCTTAAGAACATACCAAGAAAATACCAGTGAATTGTTGGATATGAATTCCCTGTTAGTTGATTTAAATCCTTTCTGAATAAAGATC
AGATAAACAGTAACTGAAGGAGCATGTATAGCTCTTTCCTTCAAATTCAACTAGAGCCTTTTTAAAAAGACATTTGCCTGCTAGTCAGAT
ACATTTACATTTATGCAAATTTTTTAAATAGGAGAAAATTAAGAAATTGTGTTAAAGGCCTAAAGTTCAGGAGTGTATTACTTTAGGTTC
TTTCCAGTTTGCTGGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGGCGGGGGGGAGGTTTATGAAGTTTTGCTCTTTGAACCACAGCTT
TATTATGGTCCTTTACACTGGAGACAGACACAGAGACACTGTTCAGAAGATGAACTAAACTCAGCAGTGGTCTGGTATCAAGAGCTTTCT
GATGTTTTACAGCCTGAATTTGGAGGGATAACGATCTGCTGTGCCTTTGCAGTCACTGCTTAGCCCAAAGTAATAGTACTTTTGATAATA
ACTCACTCTGTGCGATATTCCTGAATAAGTCCATCTCAAAAGTTTGGGATTTTCCTCCTCTTAACTTTCTTAATATTTGGACATGCAGTT
GTCGCCAAACTTGGGTATTCATGGAATTTCTAGTAAATGAAATACCTATACTTTGATACTGAAGACTGCCAAATACATAGGAATTTTCTT
TCTTAAAAAACAGTAATGAAGACTATATCTCCTTTCCCAGCACTGAATGTTTTACTAGCACTGGGTGCTCACCATGCAACTGAAGAAAAT
GTGGAAACTCAAAAGGTCAGGACAGACTTCCAAGCACTTGCAACTGATGTTACTGTCTTCAATTTTAATAATTACACATATTTGTATATT
TCAGAGAAGTTTTTAATATTTCTCTGTCCACTTTTTATAAGCTTTAAAATGATTTTCTCTGCCTTGAGATTTGCATCAAGAAAAAGCACC
TCTCTTCACCTGAAAGCTTTGAAGACTAGAGACACGCTTTACACGTTTTAACAAGTATATTGAGTCCACGTTTGGTAGCATCAGTTGTTG
AGTTAAAAAGAAAATTATTGCATTTGATCTGGATGGATTTTAAAAGAATATAATGTTCAATATTAAAAGGATAATTCACATTTGCCACCA
TAATGTTCTTTTTTATGTAAAAAGAAGAACTTGGAGACATTAACATGAAAAAGTCTTTTATCATTAGCTCATGTATTTGAGGAAGAGCAG
CTGTCTTTTTATATGTTTTTTGACAAATCATATTGTATTCTTTTGTACAAAAAAGAACTACTTGTATTCTAGAAGAAATATGAAATGCTT
AATTTATAAGCGGGCTGGAGATTTTTTCCAATATTGTTTTCTTTGAAAATGAAAGGGGATCATCTATTTTAGTTTTGGGGTCTGGGAACT
TTTTGAAAATTTAATTTGTGGACCAATGTTTTGTGAAAGCTAAAGAGGGCAGGGGTTAAAATAGGGCTTGAATTTCTCATTCTGTATAGA
CCAGCAAACTTCCCTGTGCAAGGCAAGTTTACATCACAAATCCAAGAATGTTTGCATCCTAAATGCTAGTTTGCTTCAGCCCCTAGTTAA
CCTCAGGACTTGGTTTGCATATAAAAGGTAGACAGCTGATATGTTTTCATGAATAAATATTGTCAGCCAGAAAAGGTTGGTGTCAGGTAA
TGCATATTTTTTTAAGCTTTGTTTTATATTTATTTTTCATTTAGTTTTTATTGGGAATGGTTTTCAAAGAACTCTCAGTTCTGCCTAGGT
GTTTTTGGGGGAGCCCTGTTTTCCATAGTGTAATTCCATTTAAGAGGTTGTCTAAAAGTCTTTTTAATTAATAGAAAGATTTTAATATCC
AAGAGTAGTCAAATTAAGGATATAAACTTTCCACACCTTCCTGTCGTGACAGATAAAAGCACAGAAAGGACAACCCTTGAAATCATGTAA
CGTTGGTCATTTCAATATTTTGTACCTGTTTTAAATTCTGTTAGTGTATTTACTTCATTGTAAATATTTTTGAGGGTACCTTTGTATTTT
GCTTTTGACCTTGGTTCTGTGATTTGGATGTCAACAACTTCCCTAAAAAGCACCAGTGTGTTAGGTTCTAATGTCATGACCCAATTTGTG
TTATTCATCTTTAATCCTGTTTTCAGTCTCTATGTGTACAGCAGTATTTTTAATAAAGAATTACAGAGATAAATTT

>59748_59748_4_NOTCH2NL-PAN3_NOTCH2NL_chr1_145281704_ENST00000362074_PAN3_chr13_28830428_ENST00000282391_length(amino acids)=841AA_BP=287
MKQEEGRREWGSSIGTPSPCGSAQAAAAAAAEEATEKIPALRPALLWALLALWLCCATPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKC
PEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ
WTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNG
GTCRQTGDFTFECNCLPGMSLSAGSSPLHSPKITPHTSPAPRRRSHTPNPASYMVPSSASTSVNNPVSQTPSSGQVIQKETVGGTTYFYT
DTTPAPLTGMVFPNYHIYPPTAPHVAYMQPKANAPSFFMADELRQELINRHLITMAQIDQADMPAVPTEVDSYHSLFPLEPLPPPNRIQK
SSNFGYITSCYKAVNSKDDLPYCLRRIHGFRLVNTKCMVLVDMWKKIQHSNIVTLREVFTTKAFAEPSLVFAYDFHAGGETMMSRHFNDP
NADAYFTKRKWGQHEGPLPRQHAGLLPESLIWAYIVQLSSALRTIHTAGLACRVMDPTKILITGKTRLRVNCVGVFDVLTFDNSQNNNPL
ALMAQYQQADLISLGKVVLALACNSLAGIQRENLQKAMELVTINYSSDLKNLILYLLTDQNRMRSVNDIMPMIGARFYTQLDAAQMRNDV
IEEDLAKEVQNGRLFRLLAKLGTINERPEFQKDPTWSETGDRYLLKLFRDHLFHQVTEAGAPWIDLSHIISCLNKLDAGVPEKISLISRD
EKSVLVVTYSDLKRCFENTFQELIAAANGQL

--------------------------------------------------------------
>59748_59748_5_NOTCH2NL-PAN3_NOTCH2NL_chr1_145281704_ENST00000362074_PAN3_chr13_28830428_ENST00000380958_length(transcript)=2677nt_BP=996nt
GCTGCACACCCGAGAAAGTTTCAGCCAAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAG
GCATTTGCGCTGGGCTTCGGAGCGTAGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGA
CCCCCTCCCCATGTGGATCTGCCCAGGCGGCGGCGGCGGCGGCGGCGGAGGAGGCGACCGAGAAGATACCCGCCCTGCGCCCCGCTCTGC
TGTGGGCGCTGCTGGCGCTCTGGCTGTGCTGCGCGACCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAG
GAATGTGTGTTACCTACCACAATGGCACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTG
AGAAGAACCGCTGCCAGAATGGTGGGACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAG
AGGACTGCCAGTACTCGACATCTCATCCATGCTTTGTGTCTCGACCTTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCT
ATGAGTGCACCTGTCAAGTCGGGTTTACAGGTAAGGAGTGCCAATGGACCGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCT
GTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAGTGTGAGACTGATGTCAATGAGTGTGACATTC
CAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCTTCAGGGCTTCACAGGCCAGTACTGTG
ACAGCCTGTATGTGCCCTGTGCACCCTCGCCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCC
TTCCAGGAATGTCGTTGTCTGCTGGGTCTTCCCCTCTTCATTCCCCCAAGATTACTCCACATACTTCTCCTGCTCCCAGAAGAAGAAGTC
ACACTCCAAATCCAGCAAGTTACATGGTGCCTTCTAGTGCCTCTACATCTGTTAATAATCCTGTTTCTCAGACTCCGTCTTCTGGTCAGG
TGATCCAAAAGGAAACTGTTGGTGGGACGACTTACTTCTATACAGACACAACTCCAGCACCTTTGACTGGAATGGTGTTTCCAAACTATC
ATATTTATCCTCCAACTGCACCTCACGTTGCTTATATGCAACCGAAAGCAAACGCACCTTCCTTCTTCATGGCTGATGAACTCCGACAGG
AGCTGATCAACAGACATTTAATAACAATGGCTCAAATTGATCAAGCAGATATGCCAGCAGTTCCTACAGAGGTTGACAGCTACCATAGCC
TATTCCCTCTAGAACCACTGCCACCTCCCAACCGGATACAGAAATCAAGTAATTTTGGATATATTACATCTTGCTACAAAGCTGTAAACA
GCAAAGATGATCTGCCATATTGCCTTCGGAGGATACATGGTTTTCGTCTTGTTAACACAAAGTGCATGGTGTTGGTCGACATGTGGAAGA
AAATTCAACACTCAAATATCGTAACTTTGCGTGAAGTATTTACCACTAAAGCATTTGCTGAGCCCTCTCTTGTGTTTGCATATGATTTCC
ATGCTGGAGGAGAAACTATGATGAGCAGACACTTTAATGACCCTAATGCTGATGCCTACTTCACCAAGAGAAAGTGGGGTCAGCACGAGG
GACCATTGCCCAGGCAGCATGCTGGATTATTGCCAGAATCTCTTATTTGGGCATATATTGTCCAACTAAGTTCTGCATTGCGTACCATTC
ATACAGCAGGTTTGGCATGTCGAGTTATGGATCCAACAAAGATTCTGATAACTGGCAAAACAAGGTTGCGAGTAAATTGTGTTGGAGTTT
TTGATGTTTTAACATTTGATAACAGTCAAAATAATAATCCATTGGCATTAATGGCCCAGTACCAGCAAGCAGATCTGATATCATTAGGAA
AAGTTGTGTTGGCTTTGGCTTGCAACTCTTTGGCAGGAATTCAGCGAGAGAATTTACAGAAAGCCATGGAACTGGTGACAATCAACTATT
CCTCTGACCTGAAGAATCTGATTTTGTATTTGTTGACTGACCAAAACAGGATGCGAAGTGTAAATGACATCATGCCCATGATTGGTGCTC
GATTTTATACTCAATTGGATGCTGCTCAAATGAGAAATGATGTCATAGAGGAAGACCTTGCAAAGGAGGTTCAAAATGGAAGACTGTTTA
GGCTCCTAGCAAAATTGGGAACAATCAATGAGAGGCCGGAGTTTCAGAAGGATCCCACTTGGTCAGAGACTGGAGACCGTTATCTGTTGA
AACTCTTTAGGGATCATCTTTTTCATCAGGTGACAGAAGCAGGTGCTCCCTGGATTGACCTCAGTCATATAATTTCTTGTCTTAACAAGC
TAGATGCTGGTGTGCCAGAAAAAATAAGCCTGATTTCCAGAGATGAGAAGAGTGTACTTGTGGTGACCTACAGTGACTTAAAGCGCTGCT
TTGAAAATACTTTTCAAGAACTGATTGCAGCTGCAAATGGTCAGTTGTAGTATTTGCTAAAAAAGCA

>59748_59748_5_NOTCH2NL-PAN3_NOTCH2NL_chr1_145281704_ENST00000362074_PAN3_chr13_28830428_ENST00000380958_length(amino acids)=841AA_BP=287
MKQEEGRREWGSSIGTPSPCGSAQAAAAAAAEEATEKIPALRPALLWALLALWLCCATPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKC
PEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ
WTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNG
GTCRQTGDFTFECNCLPGMSLSAGSSPLHSPKITPHTSPAPRRRSHTPNPASYMVPSSASTSVNNPVSQTPSSGQVIQKETVGGTTYFYT
DTTPAPLTGMVFPNYHIYPPTAPHVAYMQPKANAPSFFMADELRQELINRHLITMAQIDQADMPAVPTEVDSYHSLFPLEPLPPPNRIQK
SSNFGYITSCYKAVNSKDDLPYCLRRIHGFRLVNTKCMVLVDMWKKIQHSNIVTLREVFTTKAFAEPSLVFAYDFHAGGETMMSRHFNDP
NADAYFTKRKWGQHEGPLPRQHAGLLPESLIWAYIVQLSSALRTIHTAGLACRVMDPTKILITGKTRLRVNCVGVFDVLTFDNSQNNNPL
ALMAQYQQADLISLGKVVLALACNSLAGIQRENLQKAMELVTINYSSDLKNLILYLLTDQNRMRSVNDIMPMIGARFYTQLDAAQMRNDV
IEEDLAKEVQNGRLFRLLAKLGTINERPEFQKDPTWSETGDRYLLKLFRDHLFHQVTEAGAPWIDLSHIISCLNKLDAGVPEKISLISRD
EKSVLVVTYSDLKRCFENTFQELIAAANGQL

--------------------------------------------------------------
>59748_59748_6_NOTCH2NL-PAN3_NOTCH2NL_chr1_145281704_ENST00000362074_PAN3_chr13_28830428_ENST00000399613_length(transcript)=5473nt_BP=996nt
GCTGCACACCCGAGAAAGTTTCAGCCAAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAG
GCATTTGCGCTGGGCTTCGGAGCGTAGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGA
CCCCCTCCCCATGTGGATCTGCCCAGGCGGCGGCGGCGGCGGCGGCGGAGGAGGCGACCGAGAAGATACCCGCCCTGCGCCCCGCTCTGC
TGTGGGCGCTGCTGGCGCTCTGGCTGTGCTGCGCGACCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAG
GAATGTGTGTTACCTACCACAATGGCACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTG
AGAAGAACCGCTGCCAGAATGGTGGGACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAG
AGGACTGCCAGTACTCGACATCTCATCCATGCTTTGTGTCTCGACCTTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCT
ATGAGTGCACCTGTCAAGTCGGGTTTACAGGTAAGGAGTGCCAATGGACCGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCT
GTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAGTGTGAGACTGATGTCAATGAGTGTGACATTC
CAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCTTCAGGGCTTCACAGGCCAGTACTGTG
ACAGCCTGTATGTGCCCTGTGCACCCTCGCCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCC
TTCCAGGAATGTCGTTGTCTGCTGGGTCTTCCCCTCTTCATTCCCCCAAGATTACTCCACATACTTCTCCTGCTCCCAGAAGAAGAAGTC
ACACTCCAAATCCAGCAAGTTACATGGTGCCTTCTAGTGCCTCTACATCTGTTAATAATCCTGTTTCTCAGACTCCGTCTTCTGGTCAGG
TGATCCAAAAGGAAACTGTTGGTGGGACGACTTACTTCTATACAGACACAACTCCAGCACCTTTGACTGGAATGGTGTTTCCAAACTATC
ATATTTATCCTCCAACTGCACCTCACGTTGCTTATATGCAACCGAAAGCAAACGCACCTTCCTTCTTCATGGCTGATGAACTCCGACAGG
AGCTGATCAACAGACATTTAATAACAATGGCTCAAATTGATCAAGCAGATATGCCAGCAGTTCCTACAGAGGTTGACAGCTACCATAGCC
TATTCCCTCTAGAACCACTGCCACCTCCCAACCGGATACAGAAATCAAGTAATTTTGGATATATTACATCTTGCTACAAAGCTGTAAACA
GCAAAGATGATCTGCCATATTGCCTTCGGAGGATACATGGTTTTCGTCTTGTTAACACAAAGTGCATGGTGTTGGTCGACATGTGGAAGA
AAATTCAACACTCAAATATCGTAACTTTGCGTGAAGTATTTACCACTAAAGCATTTGCTGAGCCCTCTCTTGTGTTTGCATATGATTTCC
ATGCTGGAGGAGAAACTATGATGAGCAGACACTTTAATGACCCTAATGCTGATGCCTACTTCACCAAGAGAAAGTGGGGTCAGCACGAGG
GACCATTGCCCAGGCAGCATGCTGGATTATTGCCAGAATCTCTTATTTGGGCATATATTGTCCAACTAAGTTCTGCATTGCGTACCATTC
ATACAGCAGGTTTGGCATGTCGAGTTATGGATCCAACAAAGATTCTGATAACTGGCAAAACAAGGTTGCGAGTAAATTGTGTTGGAGTTT
TTGATGTTTTAACATTTGATAACAGTCAAAATAATAATCCATTGGCATTAATGGCCCAGTACCAGCAAGCAGATCTGATATCATTAGGAA
AAGTTGTGTTGGCTTTGGCTTGCAACTCTTTGGCAGGAATTCAGCGAGAGAATTTACAGAAAGCCATGGAACTGGTGACAATCAACTATT
CCTCTGACCTGAAGAATCTGATTTTGTATTTGTTGACTGACCAAAACAGGATGCGAAGTGTAAATGACATCATGCCCATGATTGGTGCTC
GATTTTATACTCAATTGGATGCTGCTCAAATGAGAAATGATGTCATAGAGGAAGACCTTGCAAAGGAGGTTCAAAATGGAAGACTGTTTA
GGCTCCTAGCAAAATTGGGAACAATCAATGAGAGGCCGGAGTTTCAGAAGGATCCCACTTGGTCAGAGACTGGAGACCGTTATCTGTTGA
AACTCTTTAGGGATCATCTTTTTCATCAGGTGACAGAAGCAGGTGCTCCCTGGATTGACCTCAGTCATATAATTTCTTGTCTTAACAAGC
TAGATGCTGGTGTGCCAGAAAAAATAAGCCTGATTTCCAGAGATGAGAAGAGTGTACTTGTGGTGACCTACAGTGACTTAAAGCGCTGCT
TTGAAAATACTTTTCAAGAACTGATTGCAGCTGCAAATGGTCAGTTGTAGTATTTGCTAAAAAAGCACGCAGGACATGGCTAAAGACCTT
AACCAATAGCAAATTGCACTACAGCTGAACTTTTCATCATCTCATTCACATTTGGGAAACGAACAGGAGATGAGCAAAGCTGCTTGCACT
TCAGTCAGGTACACTGTTACTTGAAAGGAAGAATGTTTCACTTACCCAAGAGCTATGGCTGCCATTGGAGGCTGTTATCTGTGAAGAATT
TATTTTAGATTTAGGAGCACCATCAGGTGAATGATGTTCCTGCTTTTGTTTTTTCCACTTGTATATGCACTAATTTTAATTTTTTAAAGA
CTTTTTCTGATCTTTGAACTTTTGCCACATTGTATACTTATAATGGGAAACTTTGCAAGGACATTTTTGGGAAGCAATGCTGGGCAGCGT
TTTTGCCATTGAGGGTTGCAGAATTTGCTCTTTTTGGGATGGGTTGCCCTGAATAACATTACGGACCAGGTAAATAATTTCATAGAAGTT
CAGTATAGTACGTAATTCTTGTAAGAGTATCGTATGCAAGCTCTCTGTATGCCACCCACTGTTAGTTCAAATTGAGATTTTTGTTTTGTT
TTGTTCTTAAGAACATACCAAGAAAATACCAGTGAATTGTTGGATATGAATTCCCTGTTAGTTGATTTAAATCCTTTCTGAATAAAGATC
AGATAAACAGTAACTGAAGGAGCATGTATAGCTCTTTCCTTCAAATTCAACTAGAGCCTTTTTAAAAAGACATTTGCCTGCTAGTCAGAT
ACATTTACATTTATGCAAATTTTTTAAATAGGAGAAAATTAAGAAATTGTGTTAAAGGCCTAAAGTTCAGGAGTGTATTACTTTAGGTTC
TTTCCAGTTTGCTGGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGGCGGGGGGGAGGTTTATGAAGTTTTGCTCTTTGAACCACAGCTT
TATTATGGTCCTTTACACTGGAGACAGACACAGAGACACTGTTCAGAAGATGAACTAAACTCAGCAGTGGTCTGGTATCAAGAGCTTTCT
GATGTTTTACAGCCTGAATTTGGAGGGATAACGATCTGCTGTGCCTTTGCAGTCACTGCTTAGCCCAAAGTAATAGTACTTTTGATAATA
ACTCACTCTGTGCGATATTCCTGAATAAGTCCATCTCAAAAGTTTGGGATTTTCCTCCTCTTAACTTTCTTAATATTTGGACATGCAGTT
GTCGCCAAACTTGGGTATTCATGGAATTTCTAGTAAATGAAATACCTATACTTTGATACTGAAGACTGCCAAATACATAGGAATTTTCTT
TCTTAAAAAACAGTAATGAAGACTATATCTCCTTTCCCAGCACTGAATGTTTTACTAGCACTGGGTGCTCACCATGCAACTGAAGAAAAT
GTGGAAACTCAAAAGGTCAGGACAGACTTCCAAGCACTTGCAACTGATGTTACTGTCTTCAATTTTAATAATTACACATATTTGTATATT
TCAGAGAAGTTTTTAATATTTCTCTGTCCACTTTTTATAAGCTTTAAAATGATTTTCTCTGCCTTGAGATTTGCATCAAGAAAAAGCACC
TCTCTTCACCTGAAAGCTTTGAAGACTAGAGACACGCTTTACACGTTTTAACAAGTATATTGAGTCCACGTTTGGTAGCATCAGTTGTTG
AGTTAAAAAGAAAATTATTGCATTTGATCTGGATGGATTTTAAAAGAATATAATGTTCAATATTAAAAGGATAATTCACATTTGCCACCA
TAATGTTCTTTTTTATGTAAAAAGAAGAACTTGGAGACATTAACATGAAAAAGTCTTTTATCATTAGCTCATGTATTTGAGGAAGAGCAG
CTGTCTTTTTATATGTTTTTTGACAAATCATATTGTATTCTTTTGTACAAAAAAGAACTACTTGTATTCTAGAAGAAATATGAAATGCTT
AATTTATAAGCGGGCTGGAGATTTTTTCCAATATTGTTTTCTTTGAAAATGAAAGGGGATCATCTATTTTAGTTTTGGGGTCTGGGAACT
TTTTGAAAATTTAATTTGTGGACCAATGTTTTGTGAAAGCTAAAGAGGGCAGGGGTTAAAATAGGGCTTGAATTTCTCATTCTGTATAGA
CCAGCAAACTTCCCTGTGCAAGGCAAGTTTACATCACAAATCCAAGAATGTTTGCATCCTAAATGCTAGTTTGCTTCAGCCCCTAGTTAA
CCTCAGGACTTGGTTTGCATATAAAAGGTAGACAGCTGATATGTTTTCATGAATAAATATTGTCAGCCAGAAAAGGTTGGTGTCAGGTAA
TGCATATTTTTTTAAGCTTTGTTTTATATTTATTTTTCATTTAGTTTTTATTGGGAATGGTTTTCAAAGAACTCTCAGTTCTGCCTAGGT
GTTTTTGGGGGAGCCCTGTTTTCCATAGTGTAATTCCATTTAAGAGGTTGTCTAAAAGTCTTTTTAATTAATAGAAAGATTTTAATATCC
AAGAGTAGTCAAATTAAGGATATAAACTTTCCACACCTTCCTGTCGTGACAGATAAAAGCACAGAAAGGACAACCCTTGAAATCATGTAA
CGTTGGTCATTTCAATATTTTGTACCTGTTTTAAATTCTGTTAGTGTATTTACTTCATTGTAAATATTTTTGAGGGTACCTTTGTATTTT
GCTTTTGACCTTGGTTCTGTGATTTGGATGTCAACAACTTCCCTAAAAAGCACCAGTGTGTTAGGTTCTAATGTCATGACCCAATTTGTG
TTATTCATCTTTAATCCTGTTTTCAGTCTCTATGTGTACAGCAGTATTTTTAATAAAGAATTACAGAGATAAA

>59748_59748_6_NOTCH2NL-PAN3_NOTCH2NL_chr1_145281704_ENST00000362074_PAN3_chr13_28830428_ENST00000399613_length(amino acids)=841AA_BP=287
MKQEEGRREWGSSIGTPSPCGSAQAAAAAAAEEATEKIPALRPALLWALLALWLCCATPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKC
PEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ
WTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNG
GTCRQTGDFTFECNCLPGMSLSAGSSPLHSPKITPHTSPAPRRRSHTPNPASYMVPSSASTSVNNPVSQTPSSGQVIQKETVGGTTYFYT
DTTPAPLTGMVFPNYHIYPPTAPHVAYMQPKANAPSFFMADELRQELINRHLITMAQIDQADMPAVPTEVDSYHSLFPLEPLPPPNRIQK
SSNFGYITSCYKAVNSKDDLPYCLRRIHGFRLVNTKCMVLVDMWKKIQHSNIVTLREVFTTKAFAEPSLVFAYDFHAGGETMMSRHFNDP
NADAYFTKRKWGQHEGPLPRQHAGLLPESLIWAYIVQLSSALRTIHTAGLACRVMDPTKILITGKTRLRVNCVGVFDVLTFDNSQNNNPL
ALMAQYQQADLISLGKVVLALACNSLAGIQRENLQKAMELVTINYSSDLKNLILYLLTDQNRMRSVNDIMPMIGARFYTQLDAAQMRNDV
IEEDLAKEVQNGRLFRLLAKLGTINERPEFQKDPTWSETGDRYLLKLFRDHLFHQVTEAGAPWIDLSHIISCLNKLDAGVPEKISLISRD
EKSVLVVTYSDLKRCFENTFQELIAAANGQL

--------------------------------------------------------------
>59748_59748_7_NOTCH2NL-PAN3_NOTCH2NL_chr1_145281704_ENST00000369340_PAN3_chr13_28830428_ENST00000282391_length(transcript)=5558nt_BP=1078nt
ACATGTGGGTTCTTTCAAACATACTGGACTTCCTCCTTAGGTTTTAGTTGTGTTAGTCAATAGTTGAATGTTGAAGGAGAGGATGCCAAG
GGATATTAAAGAAGTTGTCCAGTGTACAGAAGCTTACTGGAAGGAGTGGCCAACTAGTTAAAGGTTTGACACCTCAATATCAACAAAATG
CCAAGTGGATCATTTTGACTCTCACAGCAATCCAACTGGACATTTGACCATGCCCCGTGGTCAGTGGAGAGCTTCTTCTCTGAAGGCCAC
TTTTATCTAGCACATCAAGGCTATACACCTCTTTCACTAAGAAGAATTTGACACTTTTATGTTGTGAGAGCTGAGATTCACCATTCTCCA
CCATCCTGAGAAGAGCTTTGATAGAAGGGCTACTCGTGAGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGTGT
GTTACCTACCACAATGGCACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTGAGAAGAAC
CGCTGCCAGAATGGTGGGACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAGAGGACTGC
CAGTACTCGACATCTCATCCATGCTTTGTGTCTCGACCTTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCTATGAGTGC
ACCTGTCAAGTCGGGTTTACAGGTAAGGAGTGCCAATGGACCGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACT
GTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAGTGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACAC
TGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCTTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTG
TATGTGCCCTGTGCACCCTCGCCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGGA
ATGTCGTTGTCTGCTGGGTCTTCCCCTCTTCATTCCCCCAAGATTACTCCACATACTTCTCCTGCTCCCAGAAGAAGAAGTCACACTCCA
AATCCAGCAAGTTACATGGTGCCTTCTAGTGCCTCTACATCTGTTAATAATCCTGTTTCTCAGACTCCGTCTTCTGGTCAGGTGATCCAA
AAGGAAACTGTTGGTGGGACGACTTACTTCTATACAGACACAACTCCAGCACCTTTGACTGGAATGGTGTTTCCAAACTATCATATTTAT
CCTCCAACTGCACCTCACGTTGCTTATATGCAACCGAAAGCAAACGCACCTTCCTTCTTCATGGCTGATGAACTCCGACAGGAGCTGATC
AACAGACATTTAATAACAATGGCTCAAATTGATCAAGCAGATATGCCAGCAGTTCCTACAGAGGTTGACAGCTACCATAGCCTATTCCCT
CTAGAACCACTGCCACCTCCCAACCGGATACAGAAATCAAGTAATTTTGGATATATTACATCTTGCTACAAAGCTGTAAACAGCAAAGAT
GATCTGCCATATTGCCTTCGGAGGATACATGGTTTTCGTCTTGTTAACACAAAGTGCATGGTGTTGGTCGACATGTGGAAGAAAATTCAA
CACTCAAATATCGTAACTTTGCGTGAAGTATTTACCACTAAAGCATTTGCTGAGCCCTCTCTTGTGTTTGCATATGATTTCCATGCTGGA
GGAGAAACTATGATGAGCAGACACTTTAATGACCCTAATGCTGATGCCTACTTCACCAAGAGAAAGTGGGGTCAGCACGAGGGACCATTG
CCCAGGCAGCATGCTGGATTATTGCCAGAATCTCTTATTTGGGCATATATTGTCCAACTAAGTTCTGCATTGCGTACCATTCATACAGCA
GGTTTGGCATGTCGAGTTATGGATCCAACAAAGATTCTGATAACTGGCAAAACAAGGTTGCGAGTAAATTGTGTTGGAGTTTTTGATGTT
TTAACATTTGATAACAGTCAAAATAATAATCCATTGGCATTAATGGCCCAGTACCAGCAAGCAGATCTGATATCATTAGGAAAAGTTGTG
TTGGCTTTGGCTTGCAACTCTTTGGCAGGAATTCAGCGAGAGAATTTACAGAAAGCCATGGAACTGGTGACAATCAACTATTCCTCTGAC
CTGAAGAATCTGATTTTGTATTTGTTGACTGACCAAAACAGGATGCGAAGTGTAAATGACATCATGCCCATGATTGGTGCTCGATTTTAT
ACTCAATTGGATGCTGCTCAAATGAGAAATGATGTCATAGAGGAAGACCTTGCAAAGGAGGTTCAAAATGGAAGACTGTTTAGGCTCCTA
GCAAAATTGGGAACAATCAATGAGAGGCCGGAGTTTCAGAAGGATCCCACTTGGTCAGAGACTGGAGACCGTTATCTGTTGAAACTCTTT
AGGGATCATCTTTTTCATCAGGTGACAGAAGCAGGTGCTCCCTGGATTGACCTCAGTCATATAATTTCTTGTCTTAACAAGCTAGATGCT
GGTGTGCCAGAAAAAATAAGCCTGATTTCCAGAGATGAGAAGAGTGTACTTGTGGTGACCTACAGTGACTTAAAGCGCTGCTTTGAAAAT
ACTTTTCAAGAACTGATTGCAGCTGCAAATGGTCAGTTGTAGTATTTGCTAAAAAAGCACGCAGGACATGGCTAAAGACCTTAACCAATA
GCAAATTGCACTACAGCTGAACTTTTCATCATCTCATTCACATTTGGGAAACGAACAGGAGATGAGCAAAGCTGCTTGCACTTCAGTCAG
GTACACTGTTACTTGAAAGGAAGAATGTTTCACTTACCCAAGAGCTATGGCTGCCATTGGAGGCTGTTATCTGTGAAGAATTTATTTTAG
ATTTAGGAGCACCATCAGGTGAATGATGTTCCTGCTTTTGTTTTTTCCACTTGTATATGCACTAATTTTAATTTTTTAAAGACTTTTTCT
GATCTTTGAACTTTTGCCACATTGTATACTTATAATGGGAAACTTTGCAAGGACATTTTTGGGAAGCAATGCTGGGCAGCGTTTTTGCCA
TTGAGGGTTGCAGAATTTGCTCTTTTTGGGATGGGTTGCCCTGAATAACATTACGGACCAGGTAAATAATTTCATAGAAGTTCAGTATAG
TACGTAATTCTTGTAAGAGTATCGTATGCAAGCTCTCTGTATGCCACCCACTGTTAGTTCAAATTGAGATTTTTGTTTTGTTTTGTTCTT
AAGAACATACCAAGAAAATACCAGTGAATTGTTGGATATGAATTCCCTGTTAGTTGATTTAAATCCTTTCTGAATAAAGATCAGATAAAC
AGTAACTGAAGGAGCATGTATAGCTCTTTCCTTCAAATTCAACTAGAGCCTTTTTAAAAAGACATTTGCCTGCTAGTCAGATACATTTAC
ATTTATGCAAATTTTTTAAATAGGAGAAAATTAAGAAATTGTGTTAAAGGCCTAAAGTTCAGGAGTGTATTACTTTAGGTTCTTTCCAGT
TTGCTGGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGGCGGGGGGGAGGTTTATGAAGTTTTGCTCTTTGAACCACAGCTTTATTATGG
TCCTTTACACTGGAGACAGACACAGAGACACTGTTCAGAAGATGAACTAAACTCAGCAGTGGTCTGGTATCAAGAGCTTTCTGATGTTTT
ACAGCCTGAATTTGGAGGGATAACGATCTGCTGTGCCTTTGCAGTCACTGCTTAGCCCAAAGTAATAGTACTTTTGATAATAACTCACTC
TGTGCGATATTCCTGAATAAGTCCATCTCAAAAGTTTGGGATTTTCCTCCTCTTAACTTTCTTAATATTTGGACATGCAGTTGTCGCCAA
ACTTGGGTATTCATGGAATTTCTAGTAAATGAAATACCTATACTTTGATACTGAAGACTGCCAAATACATAGGAATTTTCTTTCTTAAAA
AACAGTAATGAAGACTATATCTCCTTTCCCAGCACTGAATGTTTTACTAGCACTGGGTGCTCACCATGCAACTGAAGAAAATGTGGAAAC
TCAAAAGGTCAGGACAGACTTCCAAGCACTTGCAACTGATGTTACTGTCTTCAATTTTAATAATTACACATATTTGTATATTTCAGAGAA
GTTTTTAATATTTCTCTGTCCACTTTTTATAAGCTTTAAAATGATTTTCTCTGCCTTGAGATTTGCATCAAGAAAAAGCACCTCTCTTCA
CCTGAAAGCTTTGAAGACTAGAGACACGCTTTACACGTTTTAACAAGTATATTGAGTCCACGTTTGGTAGCATCAGTTGTTGAGTTAAAA
AGAAAATTATTGCATTTGATCTGGATGGATTTTAAAAGAATATAATGTTCAATATTAAAAGGATAATTCACATTTGCCACCATAATGTTC
TTTTTTATGTAAAAAGAAGAACTTGGAGACATTAACATGAAAAAGTCTTTTATCATTAGCTCATGTATTTGAGGAAGAGCAGCTGTCTTT
TTATATGTTTTTTGACAAATCATATTGTATTCTTTTGTACAAAAAAGAACTACTTGTATTCTAGAAGAAATATGAAATGCTTAATTTATA
AGCGGGCTGGAGATTTTTTCCAATATTGTTTTCTTTGAAAATGAAAGGGGATCATCTATTTTAGTTTTGGGGTCTGGGAACTTTTTGAAA
ATTTAATTTGTGGACCAATGTTTTGTGAAAGCTAAAGAGGGCAGGGGTTAAAATAGGGCTTGAATTTCTCATTCTGTATAGACCAGCAAA
CTTCCCTGTGCAAGGCAAGTTTACATCACAAATCCAAGAATGTTTGCATCCTAAATGCTAGTTTGCTTCAGCCCCTAGTTAACCTCAGGA
CTTGGTTTGCATATAAAAGGTAGACAGCTGATATGTTTTCATGAATAAATATTGTCAGCCAGAAAAGGTTGGTGTCAGGTAATGCATATT
TTTTTAAGCTTTGTTTTATATTTATTTTTCATTTAGTTTTTATTGGGAATGGTTTTCAAAGAACTCTCAGTTCTGCCTAGGTGTTTTTGG
GGGAGCCCTGTTTTCCATAGTGTAATTCCATTTAAGAGGTTGTCTAAAAGTCTTTTTAATTAATAGAAAGATTTTAATATCCAAGAGTAG
TCAAATTAAGGATATAAACTTTCCACACCTTCCTGTCGTGACAGATAAAAGCACAGAAAGGACAACCCTTGAAATCATGTAACGTTGGTC
ATTTCAATATTTTGTACCTGTTTTAAATTCTGTTAGTGTATTTACTTCATTGTAAATATTTTTGAGGGTACCTTTGTATTTTGCTTTTGA
CCTTGGTTCTGTGATTTGGATGTCAACAACTTCCCTAAAAAGCACCAGTGTGTTAGGTTCTAATGTCATGACCCAATTTGTGTTATTCAT
CTTTAATCCTGTTTTCAGTCTCTATGTGTACAGCAGTATTTTTAATAAAGAATTACAGAGATAAATTT

>59748_59748_7_NOTCH2NL-PAN3_NOTCH2NL_chr1_145281704_ENST00000369340_PAN3_chr13_28830428_ENST00000282391_length(amino acids)=779AA_BP=225
MQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPC
LNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSY
QCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGMSLSAGSSPLHSPKITPHTSPAPRRRSHTPNPASYMVPSSASTS
VNNPVSQTPSSGQVIQKETVGGTTYFYTDTTPAPLTGMVFPNYHIYPPTAPHVAYMQPKANAPSFFMADELRQELINRHLITMAQIDQAD
MPAVPTEVDSYHSLFPLEPLPPPNRIQKSSNFGYITSCYKAVNSKDDLPYCLRRIHGFRLVNTKCMVLVDMWKKIQHSNIVTLREVFTTK
AFAEPSLVFAYDFHAGGETMMSRHFNDPNADAYFTKRKWGQHEGPLPRQHAGLLPESLIWAYIVQLSSALRTIHTAGLACRVMDPTKILI
TGKTRLRVNCVGVFDVLTFDNSQNNNPLALMAQYQQADLISLGKVVLALACNSLAGIQRENLQKAMELVTINYSSDLKNLILYLLTDQNR
MRSVNDIMPMIGARFYTQLDAAQMRNDVIEEDLAKEVQNGRLFRLLAKLGTINERPEFQKDPTWSETGDRYLLKLFRDHLFHQVTEAGAP
WIDLSHIISCLNKLDAGVPEKISLISRDEKSVLVVTYSDLKRCFENTFQELIAAANGQL

--------------------------------------------------------------
>59748_59748_8_NOTCH2NL-PAN3_NOTCH2NL_chr1_145281704_ENST00000369340_PAN3_chr13_28830428_ENST00000380958_length(transcript)=2759nt_BP=1078nt
ACATGTGGGTTCTTTCAAACATACTGGACTTCCTCCTTAGGTTTTAGTTGTGTTAGTCAATAGTTGAATGTTGAAGGAGAGGATGCCAAG
GGATATTAAAGAAGTTGTCCAGTGTACAGAAGCTTACTGGAAGGAGTGGCCAACTAGTTAAAGGTTTGACACCTCAATATCAACAAAATG
CCAAGTGGATCATTTTGACTCTCACAGCAATCCAACTGGACATTTGACCATGCCCCGTGGTCAGTGGAGAGCTTCTTCTCTGAAGGCCAC
TTTTATCTAGCACATCAAGGCTATACACCTCTTTCACTAAGAAGAATTTGACACTTTTATGTTGTGAGAGCTGAGATTCACCATTCTCCA
CCATCCTGAGAAGAGCTTTGATAGAAGGGCTACTCGTGAGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGTGT
GTTACCTACCACAATGGCACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTGAGAAGAAC
CGCTGCCAGAATGGTGGGACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAGAGGACTGC
CAGTACTCGACATCTCATCCATGCTTTGTGTCTCGACCTTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCTATGAGTGC
ACCTGTCAAGTCGGGTTTACAGGTAAGGAGTGCCAATGGACCGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACT
GTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAGTGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACAC
TGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCTTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTG
TATGTGCCCTGTGCACCCTCGCCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGGA
ATGTCGTTGTCTGCTGGGTCTTCCCCTCTTCATTCCCCCAAGATTACTCCACATACTTCTCCTGCTCCCAGAAGAAGAAGTCACACTCCA
AATCCAGCAAGTTACATGGTGCCTTCTAGTGCCTCTACATCTGTTAATAATCCTGTTTCTCAGACTCCGTCTTCTGGTCAGGTGATCCAA
AAGGAAACTGTTGGTGGGACGACTTACTTCTATACAGACACAACTCCAGCACCTTTGACTGGAATGGTGTTTCCAAACTATCATATTTAT
CCTCCAACTGCACCTCACGTTGCTTATATGCAACCGAAAGCAAACGCACCTTCCTTCTTCATGGCTGATGAACTCCGACAGGAGCTGATC
AACAGACATTTAATAACAATGGCTCAAATTGATCAAGCAGATATGCCAGCAGTTCCTACAGAGGTTGACAGCTACCATAGCCTATTCCCT
CTAGAACCACTGCCACCTCCCAACCGGATACAGAAATCAAGTAATTTTGGATATATTACATCTTGCTACAAAGCTGTAAACAGCAAAGAT
GATCTGCCATATTGCCTTCGGAGGATACATGGTTTTCGTCTTGTTAACACAAAGTGCATGGTGTTGGTCGACATGTGGAAGAAAATTCAA
CACTCAAATATCGTAACTTTGCGTGAAGTATTTACCACTAAAGCATTTGCTGAGCCCTCTCTTGTGTTTGCATATGATTTCCATGCTGGA
GGAGAAACTATGATGAGCAGACACTTTAATGACCCTAATGCTGATGCCTACTTCACCAAGAGAAAGTGGGGTCAGCACGAGGGACCATTG
CCCAGGCAGCATGCTGGATTATTGCCAGAATCTCTTATTTGGGCATATATTGTCCAACTAAGTTCTGCATTGCGTACCATTCATACAGCA
GGTTTGGCATGTCGAGTTATGGATCCAACAAAGATTCTGATAACTGGCAAAACAAGGTTGCGAGTAAATTGTGTTGGAGTTTTTGATGTT
TTAACATTTGATAACAGTCAAAATAATAATCCATTGGCATTAATGGCCCAGTACCAGCAAGCAGATCTGATATCATTAGGAAAAGTTGTG
TTGGCTTTGGCTTGCAACTCTTTGGCAGGAATTCAGCGAGAGAATTTACAGAAAGCCATGGAACTGGTGACAATCAACTATTCCTCTGAC
CTGAAGAATCTGATTTTGTATTTGTTGACTGACCAAAACAGGATGCGAAGTGTAAATGACATCATGCCCATGATTGGTGCTCGATTTTAT
ACTCAATTGGATGCTGCTCAAATGAGAAATGATGTCATAGAGGAAGACCTTGCAAAGGAGGTTCAAAATGGAAGACTGTTTAGGCTCCTA
GCAAAATTGGGAACAATCAATGAGAGGCCGGAGTTTCAGAAGGATCCCACTTGGTCAGAGACTGGAGACCGTTATCTGTTGAAACTCTTT
AGGGATCATCTTTTTCATCAGGTGACAGAAGCAGGTGCTCCCTGGATTGACCTCAGTCATATAATTTCTTGTCTTAACAAGCTAGATGCT
GGTGTGCCAGAAAAAATAAGCCTGATTTCCAGAGATGAGAAGAGTGTACTTGTGGTGACCTACAGTGACTTAAAGCGCTGCTTTGAAAAT
ACTTTTCAAGAACTGATTGCAGCTGCAAATGGTCAGTTGTAGTATTTGCTAAAAAAGCA

>59748_59748_8_NOTCH2NL-PAN3_NOTCH2NL_chr1_145281704_ENST00000369340_PAN3_chr13_28830428_ENST00000380958_length(amino acids)=779AA_BP=225
MQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPC
LNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSY
QCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGMSLSAGSSPLHSPKITPHTSPAPRRRSHTPNPASYMVPSSASTS
VNNPVSQTPSSGQVIQKETVGGTTYFYTDTTPAPLTGMVFPNYHIYPPTAPHVAYMQPKANAPSFFMADELRQELINRHLITMAQIDQAD
MPAVPTEVDSYHSLFPLEPLPPPNRIQKSSNFGYITSCYKAVNSKDDLPYCLRRIHGFRLVNTKCMVLVDMWKKIQHSNIVTLREVFTTK
AFAEPSLVFAYDFHAGGETMMSRHFNDPNADAYFTKRKWGQHEGPLPRQHAGLLPESLIWAYIVQLSSALRTIHTAGLACRVMDPTKILI
TGKTRLRVNCVGVFDVLTFDNSQNNNPLALMAQYQQADLISLGKVVLALACNSLAGIQRENLQKAMELVTINYSSDLKNLILYLLTDQNR
MRSVNDIMPMIGARFYTQLDAAQMRNDVIEEDLAKEVQNGRLFRLLAKLGTINERPEFQKDPTWSETGDRYLLKLFRDHLFHQVTEAGAP
WIDLSHIISCLNKLDAGVPEKISLISRDEKSVLVVTYSDLKRCFENTFQELIAAANGQL

--------------------------------------------------------------
>59748_59748_9_NOTCH2NL-PAN3_NOTCH2NL_chr1_145281704_ENST00000369340_PAN3_chr13_28830428_ENST00000399613_length(transcript)=5555nt_BP=1078nt
ACATGTGGGTTCTTTCAAACATACTGGACTTCCTCCTTAGGTTTTAGTTGTGTTAGTCAATAGTTGAATGTTGAAGGAGAGGATGCCAAG
GGATATTAAAGAAGTTGTCCAGTGTACAGAAGCTTACTGGAAGGAGTGGCCAACTAGTTAAAGGTTTGACACCTCAATATCAACAAAATG
CCAAGTGGATCATTTTGACTCTCACAGCAATCCAACTGGACATTTGACCATGCCCCGTGGTCAGTGGAGAGCTTCTTCTCTGAAGGCCAC
TTTTATCTAGCACATCAAGGCTATACACCTCTTTCACTAAGAAGAATTTGACACTTTTATGTTGTGAGAGCTGAGATTCACCATTCTCCA
CCATCCTGAGAAGAGCTTTGATAGAAGGGCTACTCGTGAGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGTGT
GTTACCTACCACAATGGCACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTGAGAAGAAC
CGCTGCCAGAATGGTGGGACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAGAGGACTGC
CAGTACTCGACATCTCATCCATGCTTTGTGTCTCGACCTTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCTATGAGTGC
ACCTGTCAAGTCGGGTTTACAGGTAAGGAGTGCCAATGGACCGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACT
GTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAGTGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACAC
TGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCTTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTG
TATGTGCCCTGTGCACCCTCGCCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGGA
ATGTCGTTGTCTGCTGGGTCTTCCCCTCTTCATTCCCCCAAGATTACTCCACATACTTCTCCTGCTCCCAGAAGAAGAAGTCACACTCCA
AATCCAGCAAGTTACATGGTGCCTTCTAGTGCCTCTACATCTGTTAATAATCCTGTTTCTCAGACTCCGTCTTCTGGTCAGGTGATCCAA
AAGGAAACTGTTGGTGGGACGACTTACTTCTATACAGACACAACTCCAGCACCTTTGACTGGAATGGTGTTTCCAAACTATCATATTTAT
CCTCCAACTGCACCTCACGTTGCTTATATGCAACCGAAAGCAAACGCACCTTCCTTCTTCATGGCTGATGAACTCCGACAGGAGCTGATC
AACAGACATTTAATAACAATGGCTCAAATTGATCAAGCAGATATGCCAGCAGTTCCTACAGAGGTTGACAGCTACCATAGCCTATTCCCT
CTAGAACCACTGCCACCTCCCAACCGGATACAGAAATCAAGTAATTTTGGATATATTACATCTTGCTACAAAGCTGTAAACAGCAAAGAT
GATCTGCCATATTGCCTTCGGAGGATACATGGTTTTCGTCTTGTTAACACAAAGTGCATGGTGTTGGTCGACATGTGGAAGAAAATTCAA
CACTCAAATATCGTAACTTTGCGTGAAGTATTTACCACTAAAGCATTTGCTGAGCCCTCTCTTGTGTTTGCATATGATTTCCATGCTGGA
GGAGAAACTATGATGAGCAGACACTTTAATGACCCTAATGCTGATGCCTACTTCACCAAGAGAAAGTGGGGTCAGCACGAGGGACCATTG
CCCAGGCAGCATGCTGGATTATTGCCAGAATCTCTTATTTGGGCATATATTGTCCAACTAAGTTCTGCATTGCGTACCATTCATACAGCA
GGTTTGGCATGTCGAGTTATGGATCCAACAAAGATTCTGATAACTGGCAAAACAAGGTTGCGAGTAAATTGTGTTGGAGTTTTTGATGTT
TTAACATTTGATAACAGTCAAAATAATAATCCATTGGCATTAATGGCCCAGTACCAGCAAGCAGATCTGATATCATTAGGAAAAGTTGTG
TTGGCTTTGGCTTGCAACTCTTTGGCAGGAATTCAGCGAGAGAATTTACAGAAAGCCATGGAACTGGTGACAATCAACTATTCCTCTGAC
CTGAAGAATCTGATTTTGTATTTGTTGACTGACCAAAACAGGATGCGAAGTGTAAATGACATCATGCCCATGATTGGTGCTCGATTTTAT
ACTCAATTGGATGCTGCTCAAATGAGAAATGATGTCATAGAGGAAGACCTTGCAAAGGAGGTTCAAAATGGAAGACTGTTTAGGCTCCTA
GCAAAATTGGGAACAATCAATGAGAGGCCGGAGTTTCAGAAGGATCCCACTTGGTCAGAGACTGGAGACCGTTATCTGTTGAAACTCTTT
AGGGATCATCTTTTTCATCAGGTGACAGAAGCAGGTGCTCCCTGGATTGACCTCAGTCATATAATTTCTTGTCTTAACAAGCTAGATGCT
GGTGTGCCAGAAAAAATAAGCCTGATTTCCAGAGATGAGAAGAGTGTACTTGTGGTGACCTACAGTGACTTAAAGCGCTGCTTTGAAAAT
ACTTTTCAAGAACTGATTGCAGCTGCAAATGGTCAGTTGTAGTATTTGCTAAAAAAGCACGCAGGACATGGCTAAAGACCTTAACCAATA
GCAAATTGCACTACAGCTGAACTTTTCATCATCTCATTCACATTTGGGAAACGAACAGGAGATGAGCAAAGCTGCTTGCACTTCAGTCAG
GTACACTGTTACTTGAAAGGAAGAATGTTTCACTTACCCAAGAGCTATGGCTGCCATTGGAGGCTGTTATCTGTGAAGAATTTATTTTAG
ATTTAGGAGCACCATCAGGTGAATGATGTTCCTGCTTTTGTTTTTTCCACTTGTATATGCACTAATTTTAATTTTTTAAAGACTTTTTCT
GATCTTTGAACTTTTGCCACATTGTATACTTATAATGGGAAACTTTGCAAGGACATTTTTGGGAAGCAATGCTGGGCAGCGTTTTTGCCA
TTGAGGGTTGCAGAATTTGCTCTTTTTGGGATGGGTTGCCCTGAATAACATTACGGACCAGGTAAATAATTTCATAGAAGTTCAGTATAG
TACGTAATTCTTGTAAGAGTATCGTATGCAAGCTCTCTGTATGCCACCCACTGTTAGTTCAAATTGAGATTTTTGTTTTGTTTTGTTCTT
AAGAACATACCAAGAAAATACCAGTGAATTGTTGGATATGAATTCCCTGTTAGTTGATTTAAATCCTTTCTGAATAAAGATCAGATAAAC
AGTAACTGAAGGAGCATGTATAGCTCTTTCCTTCAAATTCAACTAGAGCCTTTTTAAAAAGACATTTGCCTGCTAGTCAGATACATTTAC
ATTTATGCAAATTTTTTAAATAGGAGAAAATTAAGAAATTGTGTTAAAGGCCTAAAGTTCAGGAGTGTATTACTTTAGGTTCTTTCCAGT
TTGCTGGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGGCGGGGGGGAGGTTTATGAAGTTTTGCTCTTTGAACCACAGCTTTATTATGG
TCCTTTACACTGGAGACAGACACAGAGACACTGTTCAGAAGATGAACTAAACTCAGCAGTGGTCTGGTATCAAGAGCTTTCTGATGTTTT
ACAGCCTGAATTTGGAGGGATAACGATCTGCTGTGCCTTTGCAGTCACTGCTTAGCCCAAAGTAATAGTACTTTTGATAATAACTCACTC
TGTGCGATATTCCTGAATAAGTCCATCTCAAAAGTTTGGGATTTTCCTCCTCTTAACTTTCTTAATATTTGGACATGCAGTTGTCGCCAA
ACTTGGGTATTCATGGAATTTCTAGTAAATGAAATACCTATACTTTGATACTGAAGACTGCCAAATACATAGGAATTTTCTTTCTTAAAA
AACAGTAATGAAGACTATATCTCCTTTCCCAGCACTGAATGTTTTACTAGCACTGGGTGCTCACCATGCAACTGAAGAAAATGTGGAAAC
TCAAAAGGTCAGGACAGACTTCCAAGCACTTGCAACTGATGTTACTGTCTTCAATTTTAATAATTACACATATTTGTATATTTCAGAGAA
GTTTTTAATATTTCTCTGTCCACTTTTTATAAGCTTTAAAATGATTTTCTCTGCCTTGAGATTTGCATCAAGAAAAAGCACCTCTCTTCA
CCTGAAAGCTTTGAAGACTAGAGACACGCTTTACACGTTTTAACAAGTATATTGAGTCCACGTTTGGTAGCATCAGTTGTTGAGTTAAAA
AGAAAATTATTGCATTTGATCTGGATGGATTTTAAAAGAATATAATGTTCAATATTAAAAGGATAATTCACATTTGCCACCATAATGTTC
TTTTTTATGTAAAAAGAAGAACTTGGAGACATTAACATGAAAAAGTCTTTTATCATTAGCTCATGTATTTGAGGAAGAGCAGCTGTCTTT
TTATATGTTTTTTGACAAATCATATTGTATTCTTTTGTACAAAAAAGAACTACTTGTATTCTAGAAGAAATATGAAATGCTTAATTTATA
AGCGGGCTGGAGATTTTTTCCAATATTGTTTTCTTTGAAAATGAAAGGGGATCATCTATTTTAGTTTTGGGGTCTGGGAACTTTTTGAAA
ATTTAATTTGTGGACCAATGTTTTGTGAAAGCTAAAGAGGGCAGGGGTTAAAATAGGGCTTGAATTTCTCATTCTGTATAGACCAGCAAA
CTTCCCTGTGCAAGGCAAGTTTACATCACAAATCCAAGAATGTTTGCATCCTAAATGCTAGTTTGCTTCAGCCCCTAGTTAACCTCAGGA
CTTGGTTTGCATATAAAAGGTAGACAGCTGATATGTTTTCATGAATAAATATTGTCAGCCAGAAAAGGTTGGTGTCAGGTAATGCATATT
TTTTTAAGCTTTGTTTTATATTTATTTTTCATTTAGTTTTTATTGGGAATGGTTTTCAAAGAACTCTCAGTTCTGCCTAGGTGTTTTTGG
GGGAGCCCTGTTTTCCATAGTGTAATTCCATTTAAGAGGTTGTCTAAAAGTCTTTTTAATTAATAGAAAGATTTTAATATCCAAGAGTAG
TCAAATTAAGGATATAAACTTTCCACACCTTCCTGTCGTGACAGATAAAAGCACAGAAAGGACAACCCTTGAAATCATGTAACGTTGGTC
ATTTCAATATTTTGTACCTGTTTTAAATTCTGTTAGTGTATTTACTTCATTGTAAATATTTTTGAGGGTACCTTTGTATTTTGCTTTTGA
CCTTGGTTCTGTGATTTGGATGTCAACAACTTCCCTAAAAAGCACCAGTGTGTTAGGTTCTAATGTCATGACCCAATTTGTGTTATTCAT
CTTTAATCCTGTTTTCAGTCTCTATGTGTACAGCAGTATTTTTAATAAAGAATTACAGAGATAAA

>59748_59748_9_NOTCH2NL-PAN3_NOTCH2NL_chr1_145281704_ENST00000369340_PAN3_chr13_28830428_ENST00000399613_length(amino acids)=779AA_BP=225
MQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPC
LNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSY
QCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGMSLSAGSSPLHSPKITPHTSPAPRRRSHTPNPASYMVPSSASTS
VNNPVSQTPSSGQVIQKETVGGTTYFYTDTTPAPLTGMVFPNYHIYPPTAPHVAYMQPKANAPSFFMADELRQELINRHLITMAQIDQAD
MPAVPTEVDSYHSLFPLEPLPPPNRIQKSSNFGYITSCYKAVNSKDDLPYCLRRIHGFRLVNTKCMVLVDMWKKIQHSNIVTLREVFTTK
AFAEPSLVFAYDFHAGGETMMSRHFNDPNADAYFTKRKWGQHEGPLPRQHAGLLPESLIWAYIVQLSSALRTIHTAGLACRVMDPTKILI
TGKTRLRVNCVGVFDVLTFDNSQNNNPLALMAQYQQADLISLGKVVLALACNSLAGIQRENLQKAMELVTINYSSDLKNLILYLLTDQNR
MRSVNDIMPMIGARFYTQLDAAQMRNDVIEEDLAKEVQNGRLFRLLAKLGTINERPEFQKDPTWSETGDRYLLKLFRDHLFHQVTEAGAP
WIDLSHIISCLNKLDAGVPEKISLISRDEKSVLVVTYSDLKRCFENTFQELIAAANGQL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NOTCH2NL-PAN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for NOTCH2NL-PAN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for NOTCH2NL-PAN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource