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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CLEC3A-SPTLC2 (FusionGDB2 ID:HG10143TG9517)

Fusion Gene Summary for CLEC3A-SPTLC2

check button Fusion gene summary
Fusion gene informationFusion gene name: CLEC3A-SPTLC2
Fusion gene ID: hg10143tg9517
HgeneTgene
Gene symbol

CLEC3A

SPTLC2

Gene ID

10143

9517

Gene nameC-type lectin domain family 3 member Aserine palmitoyltransferase long chain base subunit 2
SynonymsCLECSF1HSN1C|LCB2|LCB2A|NSAN1C|SPT2|hLCB2a
Cytomap('CLEC3A')('SPTLC2')

16q23.1

14q24.3

Type of geneprotein-codingprotein-coding
DescriptionC-type lectin domain family 3 member AC-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 1 (cartilage-derived)serine palmitoyltransferase 2LCB 2SPT 2long chain base biosynthesis protein 2aserine palmitoyltransferase, subunit IIserine-palmitoyl-CoA transferase 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000299642, ENST00000575655, 
ENST00000565808, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 6 X 3=108
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLEC3A [Title/Abstract] AND SPTLC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCLEC3A(78056638)-SPTLC2(77987924), # samples:1
Anticipated loss of major functional domain due to fusion event.CLEC3A-SPTLC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLEC3A-SPTLC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSPTLC2

GO:0030148

sphingolipid biosynthetic process

25332431|26573920

TgeneSPTLC2

GO:0046513

ceramide biosynthetic process

25691431

TgeneSPTLC2

GO:1904504

positive regulation of lipophagy

25332431


check buttonFusion gene breakpoints across CLEC3A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SPTLC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0YI-01ACLEC3Achr16

78056638

+SPTLC2chr14

77987924

-


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Fusion Gene ORF analysis for CLEC3A-SPTLC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000299642ENST00000556264CLEC3Achr16

78056638

+SPTLC2chr14

77987924

-
5CDS-intronENST00000575655ENST00000556264CLEC3Achr16

78056638

+SPTLC2chr14

77987924

-
In-frameENST00000299642ENST00000216484CLEC3Achr16

78056638

+SPTLC2chr14

77987924

-
In-frameENST00000575655ENST00000216484CLEC3Achr16

78056638

+SPTLC2chr14

77987924

-
intron-3CDSENST00000565808ENST00000216484CLEC3Achr16

78056638

+SPTLC2chr14

77987924

-
intron-intronENST00000565808ENST00000556264CLEC3Achr16

78056638

+SPTLC2chr14

77987924

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000299642CLEC3Achr1678056638+ENST00000216484SPTLC2chr1477987924-690022785612175
ENST00000575655CLEC3Achr1678056638+ENST00000216484SPTLC2chr1477987924-686919654581175

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000299642ENST00000216484CLEC3Achr1678056638+SPTLC2chr1477987924-0.0043104410.9956896
ENST00000575655ENST00000216484CLEC3Achr1678056638+SPTLC2chr1477987924-0.0042512310.9957488

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Fusion Genomic Features for CLEC3A-SPTLC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CLEC3A-SPTLC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:78056638/chr14:77987924)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLEC3Achr16:78056638chr14:77987924ENST00000575655+1374_19238198.0DomainC-type lectin
TgeneSPTLC2chr16:78056638chr14:77987924ENST0000021648481267_87434563.0TransmembraneHelical


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Fusion Gene Sequence for CLEC3A-SPTLC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>17096_17096_1_CLEC3A-SPTLC2_CLEC3A_chr16_78056638_ENST00000299642_SPTLC2_chr14_77987924_ENST00000216484_length(transcript)=6900nt_BP=227nt
ACTTTTATAAGCCAGCCCCAGGCATCCCAGAGCAAGATGTAGCTGTGTAGTCTCCTTCCATAGCTGCTCTAAGGGGGCTGGCAACATGGC
TCAGCAGGCTTGCCCCAGAGCCATGGCAAAGAATGGACTTGTAATTTGCATCCTGGTGATCACCTTACTCCTGGACCAGACCACCAGCCA
CACATCCAGATTAAAAGCCAGGAAGCACAGCAAACGTCGAGTGAGAGGTAAAGAGTGTGTACAACAGTTAGCTGAAAACACCAGGTATTT
CAGGAGACGCCTGAAAGAGATGGGCTTCATCATCTATGGAAATGAAGACTCTCCAGTAGTGCCTTTGATGCTCTACATGCCTGCCAAAAT
TGGCGCCTTTGGACGGGAGATGCTGAAGCGGAACATCGGTGTCGTTGTGGTTGGATTTCCTGCCACCCCAATTATTGAGTCCAGAGCCAG
GTTTTGCCTGTCAGCAGCTCATACCAAAGAAATACTTGATACTGCTTTAAAGGAGATAGATGAAGTTGGGGACCTATTGCAGCTGAAGTA
TTCCCGTCATCGGTTGGTACCTCTACTGGACAGGCCCTTTGACGAGACGACGTATGAAGAAACAGAAGACTGAGCCTTTTTGGTGCTCCC
TCAGAGGAACTCTCCCTCACCCAGGACAGCCTGTGGCCTTTGTGAGCCAGTTCCAGGAACCACACTTCTGTGGCCATCTCACGTGAAAGA
CATTGCCTCAGCTACTGAAGGTGGCCACCTCCACTCTAAATGACATTTTGTAAATAGTAAAAAACTGCTTCTAATCCTTCCTTTGCTAAA
TCTCACCTTTAAAAACGAAGGTGACTCACTTTGCTTTTTCAGTCCATTAAAAAAACATTTTATTTTGCAACCATTCTACTTGTGAAATCA
CGCTGACCCTAGCCTGTCTCTGGCTAACCACACAGGCCATTCCCCTCTCCCAGCACCTTGCAGACTTGGGCCCATCAAGAGCTACTGCTG
GCCCTGGCTCCGCAGCCTGGATACTTACCTGGCCCTCCTCCCTAGGGAGCAAGTGCCTTCCACTTACTTCCCATCCAGGTCTCAGAGGTC
TCAAGGCCAACCTTGGAATCCTTATTTAACCATTCAAGTAATCAACGGAAGTTTTCACCCTTTAATCTTAAGTTTAGCCTTTTAAGAAAA
ACAGTAAGCGATGACTGCTGAAAGGCTCATTGTGTAATCTCCCAAGGGTTTGGTCTTATTCCATTTTCTTCTGGTCACCAGATGATTTCT
TCCTTTACCATCAAATACTTCTTCATAATGGTCACAGTCTGAGGATGTGCGCAAATTCTGGTTCTTCCCAAGCTCTAACCGTAACACGTC
CCACCCCCTTTTTAAAGCACTTACTGTTTTCAGAGCACCCATATCCCACCCTGGTGAGAAGGCCACTCTCACATCTGAGTGTTGGGTACA
AAGCTGCTCCGTAGAGTGATGTGCACTCCTGGTGGGTGAGGGGCAGGGGCAGTGGCAGTGTGCAAAGAATTGATTACTCCTTGCAGAGCC
TGTGGCTTGCATTTCCTACTGCTTTCTACGTTTGAAAATTATGACAGTCTCTGGCTAGGTCTGGGTCCAGATTAGGATTTAAACTGATAA
AGGAAACTGTTGGTAAATCCTCTGCTCAGAAAGCATTTATCATGTTCCTATTTAAGGATTAGGTTTATTAATTTAGGCCTCTTAGAAGCT
AACCCACTTAAATATTACTCTTCTGAATGCTAGTTCTCTTTTATTCTTGATGTCCTAAGTCAATTGAATCTGGCATCTGGGGCTAGGGTC
TGCCTGTCTACATATTTTTTATTTTTTTCTGAGAAATTCTGAACACATAGATCTCTTTCCTAAACTGACATTTTCTATTTTGACTGTTTT
CATACTATAACCAGGTAAAGGGACTTCTTTCAGAGAGCTTTATACTGCCTGACCAAAGAACAAATCTGAAAATCACCATTTTAAAGTTAT
TTTTTCAGTTGAACCAAAGTTTAAGTGAAGAGGACTTTTGGCATATTATACCCAGGATCAGTTTGTCTTTTTGTATCCATCAAGTATTAC
AGGAGAAGGATTGGGAACAGAATGGAAAAACAGTGTATGAAAGTCATGTTACAGGCCGAGTGCGGTGGCTCACACCTGTAATCCTAGCAC
TTTGGGAGGCTGAGGCAGGTGGCTCACTTGAGGTCAGGAATTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAAGA
CAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTATAATCCCACCTACTTGGTAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGG
AGGTTGCAGTGAGACGAGATTGTGCCACTGCACTCTAGCCTGGGTGACAGAGCAAAACTGTGTCTCAAAAAAAAAAGTCATGTTACACAT
TTAAGTTTTTGAAATTGCTCCTTTTATCGGTAAAGATTCTCAATCCAAATTCTCCTGGGTGTGTTGTCATCAGCTGTGATATGTTTGTGC
ACATTACGTATAGCAGAGGATGTAAGCAATATTATTGTTTGTGAAGTTTTGTTTTTAATGTCTTGAGTATGAGTTATGTTTAGTCACTGT
CAGCATCTGAGAACTTTAATAAGCCCTTGAGATATTCCAAAGTTTTATTTTACTTTTTTAAAGAACAGAAAAAGATGAATGAAAGAACCA
AGGAGAGATGCAGAGACTATATTTAGCATGTATAGGTTAAAGTAAGAAGGAGGTTGTGGTAACTAAATAGGAGTCCTATAAAATCAAATA
CATTGTCAACCTTTTCTGCACATCTAGTTTCCTACCATAGAATCCCACTGGAATACCACATAGCTTTTGCACTGCAGTTACTATTTACTA
ATGTAAACGTAGGGTTTGTAAAAGTCACAAACTTATAAGCAATGAACTTACCTGCTAGTCTTTTTATTTTGGCTTGCATGAAGTCACTGC
AAATTCAAATGTCAGTACCGGCATTTAAAATATATCTATATCACTTTGTTGGTACAAAGTTATTTCAAGATAAGTGTAATTTTGTTACAA
GTTTATTTTGAAGAGACAAATCTCCTGTGATCTATGCAGGACCTCTGTACTTTCTAAAGAACAAAATGTTATGTAGACATTATACATGGT
TGGTTGTCTCTTCTTGAAACTGTAATGTAAATCTAGGGTCCAGTCATATCCTAGGTATCATCATTTATCCAAGTACTTGGAGGAATACAA
GTATATATAAATACAGTCATTGAGAATAAGTCGATTTGAGGCATACAAGAGTAGTTTCTTACACAGTTTAACACGGCCTGATTCAAGACT
CTGATAGGATTCAAACAGATACCGGTTAACCATGACTACCAAAACTGATCATCTGAGTCGATTGATAGAGGTGTGACTAGTCCTTAGCAC
TTTTTCTCATTCCTCTTTTTATTCAGCATTGCTGTTACCTATTTCAGGTTTATAAGACCTCTTTCAGCAGATCACATCAGAAGCCAGGAA
ATGCATAGCTAGGAGATGTCAAAAGCCCATATGAGGAGTGGACCAAGCAGCAGTGGCGGTTTCTCCTCGCATCTTTTTTTTTTTAAGCTT
TAACTTAGCAGGGGCATGGACTTTATAGCACTTTTTCAACTTTTTGCTTTGCTTTGGATAAGAAATCCTTACCTTTAAAAAAAGCTTCTA
GTCTCCATAACCCCCAAAGTACTGCTTATTTGTTTGAAGAATCCAGCCATCGTAGTGCTTTAGTCACTATCGTAAACATTCATGATAGGG
CAAGGATTTTAAAACAGGATTCTTGCTTCTGTAGTCATCAAGGTGAACAGAAGCATCCTACACAACCACTAAGGGCTCTATGTTTGTGTC
ATGCCTCTTCAAACACCAAGGAGTTGAACATGCTTCCAGTGATTTGTCTCCGTAATGCCTTCTTCCTTTATTTGGCCTTTCTTTCTTTCT
GTACCTTCAAGTTCTTGATTTTTAAAATTCCAACTCTAGAGAAAACCAATATATGGTGGTGCTGGGCTTTGAAGATAGCATATCAGACGC
CTTGGTTCTGTTTGTACACTTAGCCTTACATTTCAGGAGGAGGCTTTTCATTAGGGGCTTAAGCTAGCTCCTTTGGCTTTTAAAAAAAAT
TTTTTTTCAAATTTCTTCATTACCTAAGGGAGCCTGCATCTAAATTTCTCAACTAGTTCAGCCTAGCTGAATTTTCTAGTGTGTTATACA
CTTTGCTTCCTTCTTATTGGTGAAAACCAGGGGGATGAGTGGCTTCCATGGAGAGATTTCCTGATTTCTCAGGGAGGAAAAAAGTGATGA
CATTTACCACTACTTTTATGTTTTTCCCCTTTTTCCAAATTGATAAGGATTTCTGGTTCCTAGTGATCCGGGATTGGGCAACAGTGCAGA
ACTGCCAGTCATGCCGTAGGCCGTGAAGAAAGAATGTGAGTAACTGTTGTTTTGCAAGGATTTGTAGGGTTATGGGCAGTTGTTGTTTGA
AGCATTGCTATGACCTAATTCCCAAGGTATCTTTCCTCTCTTGGTGTTCTAGGTAAGCCAATGAGCTTTAATCTCTACTTGCTATAACCG
TGTGCTTAGAAAAAGAGGTGAGAGTAGTGGTTTTCCTTCAAACTGTCCACATTCATGAAGATTATGAATTGTTAGGACAGCCAGGGCAAG
ATAGACCCTGTCTCTACAAAAATTTTTTTCTAAATTAACCGGGCATGGTGGTGCCTGCCTGTAGTCCCACCTGTGTGGGAGAATCACTTG
AGCCTGGGAGGTCAAGGCTGCAGTGAGCCATGATTGCACCCCTGCACTCCAGCCTGGGTGACAGAGTGAGACCCTGGCTCAATAAGAGGG
GGAAAAAAAATTGTTAGGAGCTGGGTGCGGATGCAGCCTGCAATCCCAGCTACTTGAGAGGCTGAGGCCGGAGGATTGCTTAAACCCAAG
AATTTGAGCGTAGCCTGGGCAACACAGCAAGACCCCATCTAAGAAAAAAATGTTTTTTAAATCAGCTTAGCCCAAAGGGGTTGTGAATGG
GGAGGTATAAAAAGCAAAGATTATTTTTTGGCTACTAAGCCAAGAACTTACAGGGATTTTTTTTTTCAGTCCCAGAACCTACAGATACCC
TGCTACTTGCTTCACGTGGATGCTCAGTGCCCAGCAGCCATCTTAATACATTAAACCAGTTTAAAAAATACCTTCCATGTGGAGAAAAAC
ATGTCTTTTTCTCGCCTCAACTTTATCCACATGAAATATGTGCCCATGGCTGGGCGCAGTGGCTCACCTGTAATCCCAACACTTTGGGAG
GCTGAAGCAGGCAGATTGCTTGAGGCCAGGAGTTCGAGAACAGTCTGGCCAACATGGCGAAACCTCATCTCTACTAAAATTACAAAAATT
AGCCGGGCATGGTGGCACATGCCTGTAATCCCAGCTACGTCAGGAGGCTGAGGCACAGGAATTGCTTGAACCCAAGAGGCAGAGGATGCA
ATGAGCCAAGATCACACCACTGCACTCCAGCCTTGGCGACAGAGGGAGACTCTGTCTCAAAAAAAAAAAAAAAAGGTGTGCCCAGGCCCC
TAGCCATTGCCATGTGCCCAGCCAGAGAGCCAAATTAGAGGGCTGGCTTCCCTATCACACAGAATAAATGCTAGTGCTAGCCAATGATCC
CTTTGCTTTTAATGTATAGAAAATACTGTTGTTCCTTTTGTCATTTCCAGTGACATCTGTTTTCTAAGCAGCTCTTTTCTAGGGAGGAAA
CCAAAGGGGCTAGGTTAAGACCCTAATAGAAATGTTTTTTCTAATCTCTGGTGAGTCTGGAAGTGTCACATTCACAGTCCACCCTTGGGA
GTGGCTTGGTGGAGCTGGGGACAAGGTTTTGTTTACTACATAGTGCACATGATAAATGGCCTTAAACTGTGATTCTTTCTGGTAGGATAA
GTTATAATAAACTGACCCTAAAGAATGCAATGGCTTTTAAACTGCAGTTACTGTGTTCTTAATGAAGCAATACCCAAAGCTCTGTTCTTT
TGGAGCACTTGAGGGGAGCTTGAATGAAAGGTGCAGATAAGAGCAGTACCTTGATCTTATGCTTTCTGAGTGTCCTGCCTTGTTGCCATC
TGCATGGATGAGTGAATGCTTCTATGCACGAGGAGACTCAAGCCAACTCAGAGTCTGCTTTTTCCAACGCTCTTCCCAGGTTTCTTTTGC
AAAGCTTGGTCATTTGGCCCAGGTCTTCCTGGAAAGTGGAGTACATGTCACTGACTAGGGTGGCGTGGTGTCTTTACCCTTAACATTAAG
TCTTGTTACCTCAGTGATGTGAAGCCAATGGTTGGAATTATAAAAAGCATCCTTGCTGGTTCTTCACAGGACACTGGAACCCACCCTGTC
AATTCAGCTAGCATGTCCACACAGTCTTGATGATCCCTCTCTGTAACAGGCAGCTAACATTAAGAGAAGGGGGAAAGAGAAGAAGAGAGC
AATAGCTTATGGGAGAGCTGAGATCTTACTTCGTTGACCCATATTTTTCCCCTGACCAAGTTACCTGTAAACTGGAATTTGCAAGGGGAT
GCTGTGATGATAACCCCTTTCTATTGCTGTAATGTTCATATAACCTGGGAAACTGAGAGAAGGGGATGTGTAAATAAAAGCTTAAACATT
TTAGTAATGTGTTAAAATGTCACTCTCTCTTACCCTGTTTCCCTTTTTTGCCAGATGATGATTTTTTTATTTTTATTTTGTACTTTACTG
GATGACTGTGAAGCGATGAGTATTGGGTTGGGGTAGGTGTGTTGATTTTGAGAGTGCATGTTAAGAACTGAAGGGGAACTACTTGAGATG
ACTTAAGAAGCATCCCATGCAAATATCTTGTTTTGCCCTAATAAAATATTCAGAAAGATA

>17096_17096_1_CLEC3A-SPTLC2_CLEC3A_chr16_78056638_ENST00000299642_SPTLC2_chr14_77987924_ENST00000216484_length(amino acids)=175AA_BP=47
MAQQACPRAMAKNGLVICILVITLLLDQTTSHTSRLKARKHSKRRVRGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPA
KIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRPFDETTYEETED

--------------------------------------------------------------
>17096_17096_2_CLEC3A-SPTLC2_CLEC3A_chr16_78056638_ENST00000575655_SPTLC2_chr14_77987924_ENST00000216484_length(transcript)=6869nt_BP=196nt
GCAAGATGTAGCTGTGTAGTCTCCTTCCATAGCTGCTCTAAGGGGGCTGGCAACATGGCTCAGCAGGCTTGCCCCAGAGCCATGGCAAAG
AATGGACTTGTAATTTGCATCCTGGTGATCACCTTACTCCTGGACCAGACCACCAGCCACACATCCAGATTAAAAGCCAGGAAGCACAGC
AAACGTCGAGTGAGAGGTAAAGAGTGTGTACAACAGTTAGCTGAAAACACCAGGTATTTCAGGAGACGCCTGAAAGAGATGGGCTTCATC
ATCTATGGAAATGAAGACTCTCCAGTAGTGCCTTTGATGCTCTACATGCCTGCCAAAATTGGCGCCTTTGGACGGGAGATGCTGAAGCGG
AACATCGGTGTCGTTGTGGTTGGATTTCCTGCCACCCCAATTATTGAGTCCAGAGCCAGGTTTTGCCTGTCAGCAGCTCATACCAAAGAA
ATACTTGATACTGCTTTAAAGGAGATAGATGAAGTTGGGGACCTATTGCAGCTGAAGTATTCCCGTCATCGGTTGGTACCTCTACTGGAC
AGGCCCTTTGACGAGACGACGTATGAAGAAACAGAAGACTGAGCCTTTTTGGTGCTCCCTCAGAGGAACTCTCCCTCACCCAGGACAGCC
TGTGGCCTTTGTGAGCCAGTTCCAGGAACCACACTTCTGTGGCCATCTCACGTGAAAGACATTGCCTCAGCTACTGAAGGTGGCCACCTC
CACTCTAAATGACATTTTGTAAATAGTAAAAAACTGCTTCTAATCCTTCCTTTGCTAAATCTCACCTTTAAAAACGAAGGTGACTCACTT
TGCTTTTTCAGTCCATTAAAAAAACATTTTATTTTGCAACCATTCTACTTGTGAAATCACGCTGACCCTAGCCTGTCTCTGGCTAACCAC
ACAGGCCATTCCCCTCTCCCAGCACCTTGCAGACTTGGGCCCATCAAGAGCTACTGCTGGCCCTGGCTCCGCAGCCTGGATACTTACCTG
GCCCTCCTCCCTAGGGAGCAAGTGCCTTCCACTTACTTCCCATCCAGGTCTCAGAGGTCTCAAGGCCAACCTTGGAATCCTTATTTAACC
ATTCAAGTAATCAACGGAAGTTTTCACCCTTTAATCTTAAGTTTAGCCTTTTAAGAAAAACAGTAAGCGATGACTGCTGAAAGGCTCATT
GTGTAATCTCCCAAGGGTTTGGTCTTATTCCATTTTCTTCTGGTCACCAGATGATTTCTTCCTTTACCATCAAATACTTCTTCATAATGG
TCACAGTCTGAGGATGTGCGCAAATTCTGGTTCTTCCCAAGCTCTAACCGTAACACGTCCCACCCCCTTTTTAAAGCACTTACTGTTTTC
AGAGCACCCATATCCCACCCTGGTGAGAAGGCCACTCTCACATCTGAGTGTTGGGTACAAAGCTGCTCCGTAGAGTGATGTGCACTCCTG
GTGGGTGAGGGGCAGGGGCAGTGGCAGTGTGCAAAGAATTGATTACTCCTTGCAGAGCCTGTGGCTTGCATTTCCTACTGCTTTCTACGT
TTGAAAATTATGACAGTCTCTGGCTAGGTCTGGGTCCAGATTAGGATTTAAACTGATAAAGGAAACTGTTGGTAAATCCTCTGCTCAGAA
AGCATTTATCATGTTCCTATTTAAGGATTAGGTTTATTAATTTAGGCCTCTTAGAAGCTAACCCACTTAAATATTACTCTTCTGAATGCT
AGTTCTCTTTTATTCTTGATGTCCTAAGTCAATTGAATCTGGCATCTGGGGCTAGGGTCTGCCTGTCTACATATTTTTTATTTTTTTCTG
AGAAATTCTGAACACATAGATCTCTTTCCTAAACTGACATTTTCTATTTTGACTGTTTTCATACTATAACCAGGTAAAGGGACTTCTTTC
AGAGAGCTTTATACTGCCTGACCAAAGAACAAATCTGAAAATCACCATTTTAAAGTTATTTTTTCAGTTGAACCAAAGTTTAAGTGAAGA
GGACTTTTGGCATATTATACCCAGGATCAGTTTGTCTTTTTGTATCCATCAAGTATTACAGGAGAAGGATTGGGAACAGAATGGAAAAAC
AGTGTATGAAAGTCATGTTACAGGCCGAGTGCGGTGGCTCACACCTGTAATCCTAGCACTTTGGGAGGCTGAGGCAGGTGGCTCACTTGA
GGTCAGGAATTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAAGACAAAAAATTAGCTGGGCGTGGTGGCGGGCAC
CTATAATCCCACCTACTTGGTAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGACGAGATTGTGCCACTGC
ACTCTAGCCTGGGTGACAGAGCAAAACTGTGTCTCAAAAAAAAAAGTCATGTTACACATTTAAGTTTTTGAAATTGCTCCTTTTATCGGT
AAAGATTCTCAATCCAAATTCTCCTGGGTGTGTTGTCATCAGCTGTGATATGTTTGTGCACATTACGTATAGCAGAGGATGTAAGCAATA
TTATTGTTTGTGAAGTTTTGTTTTTAATGTCTTGAGTATGAGTTATGTTTAGTCACTGTCAGCATCTGAGAACTTTAATAAGCCCTTGAG
ATATTCCAAAGTTTTATTTTACTTTTTTAAAGAACAGAAAAAGATGAATGAAAGAACCAAGGAGAGATGCAGAGACTATATTTAGCATGT
ATAGGTTAAAGTAAGAAGGAGGTTGTGGTAACTAAATAGGAGTCCTATAAAATCAAATACATTGTCAACCTTTTCTGCACATCTAGTTTC
CTACCATAGAATCCCACTGGAATACCACATAGCTTTTGCACTGCAGTTACTATTTACTAATGTAAACGTAGGGTTTGTAAAAGTCACAAA
CTTATAAGCAATGAACTTACCTGCTAGTCTTTTTATTTTGGCTTGCATGAAGTCACTGCAAATTCAAATGTCAGTACCGGCATTTAAAAT
ATATCTATATCACTTTGTTGGTACAAAGTTATTTCAAGATAAGTGTAATTTTGTTACAAGTTTATTTTGAAGAGACAAATCTCCTGTGAT
CTATGCAGGACCTCTGTACTTTCTAAAGAACAAAATGTTATGTAGACATTATACATGGTTGGTTGTCTCTTCTTGAAACTGTAATGTAAA
TCTAGGGTCCAGTCATATCCTAGGTATCATCATTTATCCAAGTACTTGGAGGAATACAAGTATATATAAATACAGTCATTGAGAATAAGT
CGATTTGAGGCATACAAGAGTAGTTTCTTACACAGTTTAACACGGCCTGATTCAAGACTCTGATAGGATTCAAACAGATACCGGTTAACC
ATGACTACCAAAACTGATCATCTGAGTCGATTGATAGAGGTGTGACTAGTCCTTAGCACTTTTTCTCATTCCTCTTTTTATTCAGCATTG
CTGTTACCTATTTCAGGTTTATAAGACCTCTTTCAGCAGATCACATCAGAAGCCAGGAAATGCATAGCTAGGAGATGTCAAAAGCCCATA
TGAGGAGTGGACCAAGCAGCAGTGGCGGTTTCTCCTCGCATCTTTTTTTTTTTAAGCTTTAACTTAGCAGGGGCATGGACTTTATAGCAC
TTTTTCAACTTTTTGCTTTGCTTTGGATAAGAAATCCTTACCTTTAAAAAAAGCTTCTAGTCTCCATAACCCCCAAAGTACTGCTTATTT
GTTTGAAGAATCCAGCCATCGTAGTGCTTTAGTCACTATCGTAAACATTCATGATAGGGCAAGGATTTTAAAACAGGATTCTTGCTTCTG
TAGTCATCAAGGTGAACAGAAGCATCCTACACAACCACTAAGGGCTCTATGTTTGTGTCATGCCTCTTCAAACACCAAGGAGTTGAACAT
GCTTCCAGTGATTTGTCTCCGTAATGCCTTCTTCCTTTATTTGGCCTTTCTTTCTTTCTGTACCTTCAAGTTCTTGATTTTTAAAATTCC
AACTCTAGAGAAAACCAATATATGGTGGTGCTGGGCTTTGAAGATAGCATATCAGACGCCTTGGTTCTGTTTGTACACTTAGCCTTACAT
TTCAGGAGGAGGCTTTTCATTAGGGGCTTAAGCTAGCTCCTTTGGCTTTTAAAAAAAATTTTTTTTCAAATTTCTTCATTACCTAAGGGA
GCCTGCATCTAAATTTCTCAACTAGTTCAGCCTAGCTGAATTTTCTAGTGTGTTATACACTTTGCTTCCTTCTTATTGGTGAAAACCAGG
GGGATGAGTGGCTTCCATGGAGAGATTTCCTGATTTCTCAGGGAGGAAAAAAGTGATGACATTTACCACTACTTTTATGTTTTTCCCCTT
TTTCCAAATTGATAAGGATTTCTGGTTCCTAGTGATCCGGGATTGGGCAACAGTGCAGAACTGCCAGTCATGCCGTAGGCCGTGAAGAAA
GAATGTGAGTAACTGTTGTTTTGCAAGGATTTGTAGGGTTATGGGCAGTTGTTGTTTGAAGCATTGCTATGACCTAATTCCCAAGGTATC
TTTCCTCTCTTGGTGTTCTAGGTAAGCCAATGAGCTTTAATCTCTACTTGCTATAACCGTGTGCTTAGAAAAAGAGGTGAGAGTAGTGGT
TTTCCTTCAAACTGTCCACATTCATGAAGATTATGAATTGTTAGGACAGCCAGGGCAAGATAGACCCTGTCTCTACAAAAATTTTTTTCT
AAATTAACCGGGCATGGTGGTGCCTGCCTGTAGTCCCACCTGTGTGGGAGAATCACTTGAGCCTGGGAGGTCAAGGCTGCAGTGAGCCAT
GATTGCACCCCTGCACTCCAGCCTGGGTGACAGAGTGAGACCCTGGCTCAATAAGAGGGGGAAAAAAAATTGTTAGGAGCTGGGTGCGGA
TGCAGCCTGCAATCCCAGCTACTTGAGAGGCTGAGGCCGGAGGATTGCTTAAACCCAAGAATTTGAGCGTAGCCTGGGCAACACAGCAAG
ACCCCATCTAAGAAAAAAATGTTTTTTAAATCAGCTTAGCCCAAAGGGGTTGTGAATGGGGAGGTATAAAAAGCAAAGATTATTTTTTGG
CTACTAAGCCAAGAACTTACAGGGATTTTTTTTTTCAGTCCCAGAACCTACAGATACCCTGCTACTTGCTTCACGTGGATGCTCAGTGCC
CAGCAGCCATCTTAATACATTAAACCAGTTTAAAAAATACCTTCCATGTGGAGAAAAACATGTCTTTTTCTCGCCTCAACTTTATCCACA
TGAAATATGTGCCCATGGCTGGGCGCAGTGGCTCACCTGTAATCCCAACACTTTGGGAGGCTGAAGCAGGCAGATTGCTTGAGGCCAGGA
GTTCGAGAACAGTCTGGCCAACATGGCGAAACCTCATCTCTACTAAAATTACAAAAATTAGCCGGGCATGGTGGCACATGCCTGTAATCC
CAGCTACGTCAGGAGGCTGAGGCACAGGAATTGCTTGAACCCAAGAGGCAGAGGATGCAATGAGCCAAGATCACACCACTGCACTCCAGC
CTTGGCGACAGAGGGAGACTCTGTCTCAAAAAAAAAAAAAAAAGGTGTGCCCAGGCCCCTAGCCATTGCCATGTGCCCAGCCAGAGAGCC
AAATTAGAGGGCTGGCTTCCCTATCACACAGAATAAATGCTAGTGCTAGCCAATGATCCCTTTGCTTTTAATGTATAGAAAATACTGTTG
TTCCTTTTGTCATTTCCAGTGACATCTGTTTTCTAAGCAGCTCTTTTCTAGGGAGGAAACCAAAGGGGCTAGGTTAAGACCCTAATAGAA
ATGTTTTTTCTAATCTCTGGTGAGTCTGGAAGTGTCACATTCACAGTCCACCCTTGGGAGTGGCTTGGTGGAGCTGGGGACAAGGTTTTG
TTTACTACATAGTGCACATGATAAATGGCCTTAAACTGTGATTCTTTCTGGTAGGATAAGTTATAATAAACTGACCCTAAAGAATGCAAT
GGCTTTTAAACTGCAGTTACTGTGTTCTTAATGAAGCAATACCCAAAGCTCTGTTCTTTTGGAGCACTTGAGGGGAGCTTGAATGAAAGG
TGCAGATAAGAGCAGTACCTTGATCTTATGCTTTCTGAGTGTCCTGCCTTGTTGCCATCTGCATGGATGAGTGAATGCTTCTATGCACGA
GGAGACTCAAGCCAACTCAGAGTCTGCTTTTTCCAACGCTCTTCCCAGGTTTCTTTTGCAAAGCTTGGTCATTTGGCCCAGGTCTTCCTG
GAAAGTGGAGTACATGTCACTGACTAGGGTGGCGTGGTGTCTTTACCCTTAACATTAAGTCTTGTTACCTCAGTGATGTGAAGCCAATGG
TTGGAATTATAAAAAGCATCCTTGCTGGTTCTTCACAGGACACTGGAACCCACCCTGTCAATTCAGCTAGCATGTCCACACAGTCTTGAT
GATCCCTCTCTGTAACAGGCAGCTAACATTAAGAGAAGGGGGAAAGAGAAGAAGAGAGCAATAGCTTATGGGAGAGCTGAGATCTTACTT
CGTTGACCCATATTTTTCCCCTGACCAAGTTACCTGTAAACTGGAATTTGCAAGGGGATGCTGTGATGATAACCCCTTTCTATTGCTGTA
ATGTTCATATAACCTGGGAAACTGAGAGAAGGGGATGTGTAAATAAAAGCTTAAACATTTTAGTAATGTGTTAAAATGTCACTCTCTCTT
ACCCTGTTTCCCTTTTTTGCCAGATGATGATTTTTTTATTTTTATTTTGTACTTTACTGGATGACTGTGAAGCGATGAGTATTGGGTTGG
GGTAGGTGTGTTGATTTTGAGAGTGCATGTTAAGAACTGAAGGGGAACTACTTGAGATGACTTAAGAAGCATCCCATGCAAATATCTTGT
TTTGCCCTAATAAAATATTCAGAAAGATA

>17096_17096_2_CLEC3A-SPTLC2_CLEC3A_chr16_78056638_ENST00000575655_SPTLC2_chr14_77987924_ENST00000216484_length(amino acids)=175AA_BP=47
MAQQACPRAMAKNGLVICILVITLLLDQTTSHTSRLKARKHSKRRVRGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPA
KIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRPFDETTYEETED

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Fusion Gene PPI Analysis for CLEC3A-SPTLC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CLEC3A-SPTLC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CLEC3A-SPTLC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC3150896NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE IC5CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0020071Hereditary Sensory Autonomic Neuropathy, Type 13GENOMICS_ENGLAND;ORPHANET
TgeneC0007959Charcot-Marie-Tooth Disease1GENOMICS_ENGLAND
TgeneC0013364Dysautonomia, Familial1GENOMICS_ENGLAND