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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CDK4-IL1R1 (FusionGDB2 ID:HG1019TG3554) |
Fusion Gene Summary for CDK4-IL1R1 |
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Fusion gene information | Fusion gene name: CDK4-IL1R1 | Fusion gene ID: hg1019tg3554 | Hgene | Tgene | Gene symbol | CDK4 | IL1R1 | Gene ID | 1019 | 3554 |
Gene name | cyclin dependent kinase 4 | interleukin 1 receptor type 1 | |
Synonyms | CMM3|PSK-J3 | CD121A|D2S1473|IL-1R-alpha|IL1R|IL1RA|P80 | |
Cytomap | ('CDK4')('IL1R1') 12q14.1 | 2q11.2-q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | cyclin-dependent kinase 4cell division protein kinase 4 | interleukin-1 receptor type 1CD121 antigen-like family member AIL-1R-1IL-1RT-1IL-1RT1interleukin 1 receptor alpha, type Iinterleukin-1 receptor alphainterleukin-1 receptor type I | |
Modification date | 20200329 | 20200313 | |
UniProtAcc | P11802 | . | |
Ensembl transtripts involved in fusion gene | ENST00000257904, ENST00000312990, ENST00000540325, ENST00000549606, ENST00000551888, | ||
Fusion gene scores | * DoF score | 8 X 7 X 3=168 | 5 X 6 X 2=60 |
# samples | 8 | 6 | |
** MAII score | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/60*10)=0 | |
Context | PubMed: CDK4 [Title/Abstract] AND IL1R1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CDK4(58141808)-IL1R1(102793174), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CDK4 | GO:0006468 | protein phosphorylation | 8114739 |
Hgene | CDK4 | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle | 19124461 |
Hgene | CDK4 | GO:0071157 | negative regulation of cell cycle arrest | 19124461 |
Tgene | IL1R1 | GO:0032729 | positive regulation of interferon-gamma production | 10653850 |
Tgene | IL1R1 | GO:0070498 | interleukin-1-mediated signaling pathway | 10383454 |
Tgene | IL1R1 | GO:0070555 | response to interleukin-1 | 10383454 |
Tgene | IL1R1 | GO:2000556 | positive regulation of T-helper 1 cell cytokine production | 10653850 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for CDK4-IL1R1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CDK4-IL1R1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CDK4-IL1R1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:58141808/:102793174) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CDK4 | . |
FUNCTION: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:18827403, ECO:0000269|PubMed:9003781}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CDK4-IL1R1 |
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Fusion Gene PPI Analysis for CDK4-IL1R1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CDK4-IL1R1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | CDK4 | P11802 | DB09073 | Palbociclib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | CDK4 | P11802 | DB11730 | Ribociclib | Antagonist|Inhibitor | Small molecule | Approved|Investigational |
Hgene | CDK4 | P11802 | DB12001 | Abemaciclib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | CDK4 | P11802 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
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Related Diseases for CDK4-IL1R1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CDK4 | C1836892 | MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3 | 9 | CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | CDK4 | C0024668 | Mammary Neoplasms, Experimental | 3 | CTD_human |
Hgene | CDK4 | C0007097 | Carcinoma | 2 | CTD_human |
Hgene | CDK4 | C0023827 | liposarcoma | 2 | CGI;CTD_human |
Hgene | CDK4 | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
Hgene | CDK4 | C0205696 | Anaplastic carcinoma | 2 | CTD_human |
Hgene | CDK4 | C0205697 | Carcinoma, Spindle-Cell | 2 | CTD_human |
Hgene | CDK4 | C0205698 | Undifferentiated carcinoma | 2 | CTD_human |
Hgene | CDK4 | C0205699 | Carcinomatosis | 2 | CTD_human |
Hgene | CDK4 | C0205824 | Liposarcoma, Dedifferentiated | 2 | CTD_human;ORPHANET |
Hgene | CDK4 | C0205825 | Liposarcoma, Pleomorphic | 2 | CTD_human |
Hgene | CDK4 | C1257925 | Mammary Carcinoma, Animal | 2 | CTD_human |
Hgene | CDK4 | C1370889 | Liposarcoma, well differentiated | 2 | CTD_human;ORPHANET |
Hgene | CDK4 | C0006118 | Brain Neoplasms | 1 | CTD_human |
Hgene | CDK4 | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
Hgene | CDK4 | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
Hgene | CDK4 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | CDK4 | C0153633 | Malignant neoplasm of brain | 1 | CTD_human |
Hgene | CDK4 | C0496899 | Benign neoplasm of brain, unspecified | 1 | CTD_human |
Hgene | CDK4 | C0677866 | Brain Stem Neoplasms | 1 | CTD_human |
Hgene | CDK4 | C0750974 | Brain Tumor, Primary | 1 | CTD_human |
Hgene | CDK4 | C0750977 | Recurrent Brain Neoplasm | 1 | CTD_human |
Hgene | CDK4 | C0750979 | Primary malignant neoplasm of brain | 1 | CTD_human |
Hgene | CDK4 | C0751886 | Brain Stem Neoplasms, Primary | 1 | CTD_human |
Hgene | CDK4 | C0751887 | Medullary Neoplasms | 1 | CTD_human |
Hgene | CDK4 | C0751888 | Mesencephalic Neoplasms | 1 | CTD_human |
Hgene | CDK4 | C0751889 | Pontine Tumors | 1 | CTD_human |
Hgene | CDK4 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
Hgene | CDK4 | C1527390 | Neoplasms, Intracranial | 1 | CTD_human |
Hgene | CDK4 | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
Hgene | CDK4 | C2239176 | Liver carcinoma | 1 | CTD_human |
Hgene | CDK4 | C2314896 | Familial Atypical Mole Melanoma Syndrome | 1 | ORPHANET |
Tgene | C0014175 | Endometriosis | 2 | CTD_human | |
Tgene | C0269102 | Endometrioma | 2 | CTD_human | |
Tgene | C0020517 | Hypersensitivity | 1 | CTD_human | |
Tgene | C0032285 | Pneumonia | 1 | CTD_human | |
Tgene | C0032300 | Lobar Pneumonia | 1 | CTD_human | |
Tgene | C0037274 | Dermatologic disorders | 1 | CTD_human | |
Tgene | C0887898 | Experimental Lung Inflammation | 1 | CTD_human | |
Tgene | C1527304 | Allergic Reaction | 1 | CTD_human | |
Tgene | C3714636 | Pneumonitis | 1 | CTD_human |