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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EIF1-PPA2 (FusionGDB2 ID:HG10209TG27068)

Fusion Gene Summary for EIF1-PPA2

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF1-PPA2
Fusion gene ID: hg10209tg27068
HgeneTgene
Gene symbol

EIF1

PPA2

Gene ID

10209

27068

Gene nameeukaryotic translation initiation factor 1inorganic pyrophosphatase 2
SynonymsA121|EIF-1|EIF1A|ISO1|SUI1HSPC124|SCFAI|SCFI|SID6-306
Cytomap('EIF1')('PPA2')

17q21.2

4q24

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 1protein translation factor SUI1 homologsui1iso1inorganic pyrophosphatase 2, mitochondrialPPase 2pyrophosphatase (inorganic) 2pyrophosphatase SID6-306pyrophosphate phospho-hydrolase 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000310837, ENST00000469257, 
ENST00000591776, 
Fusion gene scores* DoF score13 X 10 X 3=39017 X 10 X 8=1360
# samples 1418
** MAII scorelog2(14/390*10)=-1.47804729680464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1360*10)=-2.91753783980803
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF1 [Title/Abstract] AND PPA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEIF1(39845321)-PPA2(106320321), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF1

GO:0006446

regulation of translational initiation

22156057


check buttonFusion gene breakpoints across EIF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PPA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-6455EIF1chr17

39845321

+PPA2chr4

106320321

-


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Fusion Gene ORF analysis for EIF1-PPA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000310837ENST00000341695EIF1chr17

39845321

+PPA2chr4

106320321

-
3UTR-3CDSENST00000310837ENST00000348706EIF1chr17

39845321

+PPA2chr4

106320321

-
3UTR-3CDSENST00000310837ENST00000354147EIF1chr17

39845321

+PPA2chr4

106320321

-
3UTR-3CDSENST00000310837ENST00000357415EIF1chr17

39845321

+PPA2chr4

106320321

-
3UTR-3CDSENST00000310837ENST00000380004EIF1chr17

39845321

+PPA2chr4

106320321

-
3UTR-3CDSENST00000310837ENST00000432483EIF1chr17

39845321

+PPA2chr4

106320321

-
3UTR-5UTRENST00000310837ENST00000509426EIF1chr17

39845321

+PPA2chr4

106320321

-
3UTR-intronENST00000310837ENST00000310267EIF1chr17

39845321

+PPA2chr4

106320321

-
5CDS-5UTRENST00000469257ENST00000509426EIF1chr17

39845321

+PPA2chr4

106320321

-
5CDS-5UTRENST00000591776ENST00000509426EIF1chr17

39845321

+PPA2chr4

106320321

-
5CDS-intronENST00000469257ENST00000310267EIF1chr17

39845321

+PPA2chr4

106320321

-
5CDS-intronENST00000591776ENST00000310267EIF1chr17

39845321

+PPA2chr4

106320321

-
In-frameENST00000469257ENST00000341695EIF1chr17

39845321

+PPA2chr4

106320321

-
In-frameENST00000469257ENST00000348706EIF1chr17

39845321

+PPA2chr4

106320321

-
In-frameENST00000469257ENST00000354147EIF1chr17

39845321

+PPA2chr4

106320321

-
In-frameENST00000469257ENST00000357415EIF1chr17

39845321

+PPA2chr4

106320321

-
In-frameENST00000469257ENST00000380004EIF1chr17

39845321

+PPA2chr4

106320321

-
In-frameENST00000469257ENST00000432483EIF1chr17

39845321

+PPA2chr4

106320321

-
In-frameENST00000591776ENST00000341695EIF1chr17

39845321

+PPA2chr4

106320321

-
In-frameENST00000591776ENST00000348706EIF1chr17

39845321

+PPA2chr4

106320321

-
In-frameENST00000591776ENST00000354147EIF1chr17

39845321

+PPA2chr4

106320321

-
In-frameENST00000591776ENST00000357415EIF1chr17

39845321

+PPA2chr4

106320321

-
In-frameENST00000591776ENST00000380004EIF1chr17

39845321

+PPA2chr4

106320321

-
In-frameENST00000591776ENST00000432483EIF1chr17

39845321

+PPA2chr4

106320321

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000591776EIF1chr1739845321+ENST00000341695PPA2chr4106320321-11811838532174
ENST00000591776EIF1chr1739845321+ENST00000348706PPA2chr4106320321-10151838532174
ENST00000591776EIF1chr1739845321+ENST00000432483PPA2chr4106320321-6931838532174
ENST00000591776EIF1chr1739845321+ENST00000354147PPA2chr4106320321-6931838532174
ENST00000591776EIF1chr1739845321+ENST00000380004PPA2chr4106320321-6901838532174
ENST00000591776EIF1chr1739845321+ENST00000357415PPA2chr4106320321-6901838532174
ENST00000469257EIF1chr1739845321+ENST00000341695PPA2chr4106320321-11751772526174
ENST00000469257EIF1chr1739845321+ENST00000348706PPA2chr4106320321-10091772526174
ENST00000469257EIF1chr1739845321+ENST00000432483PPA2chr4106320321-6871772526174
ENST00000469257EIF1chr1739845321+ENST00000354147PPA2chr4106320321-6871772526174
ENST00000469257EIF1chr1739845321+ENST00000380004PPA2chr4106320321-6841772526174
ENST00000469257EIF1chr1739845321+ENST00000357415PPA2chr4106320321-6841772526174

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000591776ENST00000341695EIF1chr1739845321+PPA2chr4106320321-0.0158542060.9841458
ENST00000591776ENST00000348706EIF1chr1739845321+PPA2chr4106320321-0.0184236280.98157644
ENST00000591776ENST00000432483EIF1chr1739845321+PPA2chr4106320321-0.0092231250.9907769
ENST00000591776ENST00000354147EIF1chr1739845321+PPA2chr4106320321-0.0092231250.9907769
ENST00000591776ENST00000380004EIF1chr1739845321+PPA2chr4106320321-0.0087800590.99121994
ENST00000591776ENST00000357415EIF1chr1739845321+PPA2chr4106320321-0.0087800590.99121994
ENST00000469257ENST00000341695EIF1chr1739845321+PPA2chr4106320321-0.0146222640.98537767
ENST00000469257ENST00000348706EIF1chr1739845321+PPA2chr4106320321-0.0173819830.98261803
ENST00000469257ENST00000432483EIF1chr1739845321+PPA2chr4106320321-0.0088022880.99119765
ENST00000469257ENST00000354147EIF1chr1739845321+PPA2chr4106320321-0.0088022880.99119765
ENST00000469257ENST00000380004EIF1chr1739845321+PPA2chr4106320321-0.0082840930.99171597
ENST00000469257ENST00000357415EIF1chr1739845321+PPA2chr4106320321-0.0082840930.99171597

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Fusion Genomic Features for EIF1-PPA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for EIF1-PPA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:39845321/chr4:106320321)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for EIF1-PPA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>25639_25639_1_EIF1-PPA2_EIF1_chr17_39845321_ENST00000469257_PPA2_chr4_106320321_ENST00000341695_length(transcript)=1175nt_BP=177nt
CACTGAGCCGCCGCCGAGGATTCAGCAGCCTCCCCCTTGAGCCCCCTCGCTTCCCGACGTTCCGTTCCCCCCTGCCCGCCTTCTCCCGCC
ACCGCCGCCGCCGCCTTCCGCAGGCCGTTTCCACCGAGGAAAAGGAATCGTATCGTATGTCCGCTATCCAGAACCTCCACTCTTTCGATA
TTGATGATGTTAAGAAGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAA
ACCAGTTTGCTTTTAATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTA
TGAAGAAGTGTAATGGAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCAT
TAGTTGAATCGGTATCATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGA
AATTCTGCTGTCAAGATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTT
CATTTTTTCAAACTTTTTGAGCTATGCAATATATAAATAAACAGTAAGAATTTTAAATTACTCTCCTTTGGACATTTATTGATATAAAAA
GAAGATTTTGGCCAGGCACGGTGGCTCATGCCTGTAATTTCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACAAGGTCAGGAGTTCAAG
ACCAGCCTGGCCAGTATGTTGAAACCCCATCTCTATTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGCATGCCTGTAGACCCAGCTAC
TCAGGAGGCTGAGGCAGAAGAACTGCTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGCAGAGATTGTGCCACTGCACTCCAGCCTAGGCGA
CAGAGAGAGACTCCGTCTCAAAAAAAAAAAAAAGATTTTGTTTCATTTCATAGCACAAATTTAGAGGCATTGAGTTGACCATTTCTAGTT
TCTATACCTGAAGGAACCCATTGATTTTACCAGTTTTTATTTCTGTAGATTGGATGTAAAAATCACAGATTCAATAAATTAATAAACTTT

>25639_25639_1_EIF1-PPA2_EIF1_chr17_39845321_ENST00000469257_PPA2_chr4_106320321_ENST00000341695_length(amino acids)=174AA_BP=58
LSRRRGFSSLPLEPPRFPTFRSPLPAFSRHRRRRLPQAVSTEEKESYRMSAIQNLHSFDIDDVKKFKPGYLEATLNWFRLYKVPDGKPEN

--------------------------------------------------------------
>25639_25639_2_EIF1-PPA2_EIF1_chr17_39845321_ENST00000469257_PPA2_chr4_106320321_ENST00000348706_length(transcript)=1009nt_BP=177nt
CACTGAGCCGCCGCCGAGGATTCAGCAGCCTCCCCCTTGAGCCCCCTCGCTTCCCGACGTTCCGTTCCCCCCTGCCCGCCTTCTCCCGCC
ACCGCCGCCGCCGCCTTCCGCAGGCCGTTTCCACCGAGGAAAAGGAATCGTATCGTATGTCCGCTATCCAGAACCTCCACTCTTTCGATA
TTGATGATGTTAAGAAGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAA
ACCAGTTTGCTTTTAATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTA
TGAAGAAGTGTAATGGAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCAT
TAGTTGAATCGGTATCATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGA
AATTCTGCTGTCAAGATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTT
CATTTTTTCAAACTTTTTGAGCTATGCAATATATAAATAAACAGTAAGAATTTTAAATTACTCTCCTTTGGACATTTATTGATATAAAAA
GAAGATTTTGGCCAGGCACGGTGGCTCATGCCTGTAATTTCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACAAGGTCAGGAGTTCAAG
ACCAGCCTGGCCAGTATGTTGAAACCCCATCTCTATTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGCATGCCTGTAGACCCAGCTAC
TCAGGAGGCTGAGGCAGAAGAACTGCTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGCAGAGATTGTGCCACTGCACTCCAGCCTAGGCGA

>25639_25639_2_EIF1-PPA2_EIF1_chr17_39845321_ENST00000469257_PPA2_chr4_106320321_ENST00000348706_length(amino acids)=174AA_BP=58
LSRRRGFSSLPLEPPRFPTFRSPLPAFSRHRRRRLPQAVSTEEKESYRMSAIQNLHSFDIDDVKKFKPGYLEATLNWFRLYKVPDGKPEN

--------------------------------------------------------------
>25639_25639_3_EIF1-PPA2_EIF1_chr17_39845321_ENST00000469257_PPA2_chr4_106320321_ENST00000354147_length(transcript)=687nt_BP=177nt
CACTGAGCCGCCGCCGAGGATTCAGCAGCCTCCCCCTTGAGCCCCCTCGCTTCCCGACGTTCCGTTCCCCCCTGCCCGCCTTCTCCCGCC
ACCGCCGCCGCCGCCTTCCGCAGGCCGTTTCCACCGAGGAAAAGGAATCGTATCGTATGTCCGCTATCCAGAACCTCCACTCTTTCGATA
TTGATGATGTTAAGAAGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAA
ACCAGTTTGCTTTTAATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTA
TGAAGAAGTGTAATGGAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCAT
TAGTTGAATCGGTATCATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGA
AATTCTGCTGTCAAGATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTT

>25639_25639_3_EIF1-PPA2_EIF1_chr17_39845321_ENST00000469257_PPA2_chr4_106320321_ENST00000354147_length(amino acids)=174AA_BP=58
LSRRRGFSSLPLEPPRFPTFRSPLPAFSRHRRRRLPQAVSTEEKESYRMSAIQNLHSFDIDDVKKFKPGYLEATLNWFRLYKVPDGKPEN

--------------------------------------------------------------
>25639_25639_4_EIF1-PPA2_EIF1_chr17_39845321_ENST00000469257_PPA2_chr4_106320321_ENST00000357415_length(transcript)=684nt_BP=177nt
CACTGAGCCGCCGCCGAGGATTCAGCAGCCTCCCCCTTGAGCCCCCTCGCTTCCCGACGTTCCGTTCCCCCCTGCCCGCCTTCTCCCGCC
ACCGCCGCCGCCGCCTTCCGCAGGCCGTTTCCACCGAGGAAAAGGAATCGTATCGTATGTCCGCTATCCAGAACCTCCACTCTTTCGATA
TTGATGATGTTAAGAAGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAA
ACCAGTTTGCTTTTAATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTA
TGAAGAAGTGTAATGGAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCAT
TAGTTGAATCGGTATCATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGA
AATTCTGCTGTCAAGATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTT

>25639_25639_4_EIF1-PPA2_EIF1_chr17_39845321_ENST00000469257_PPA2_chr4_106320321_ENST00000357415_length(amino acids)=174AA_BP=58
LSRRRGFSSLPLEPPRFPTFRSPLPAFSRHRRRRLPQAVSTEEKESYRMSAIQNLHSFDIDDVKKFKPGYLEATLNWFRLYKVPDGKPEN

--------------------------------------------------------------
>25639_25639_5_EIF1-PPA2_EIF1_chr17_39845321_ENST00000469257_PPA2_chr4_106320321_ENST00000380004_length(transcript)=684nt_BP=177nt
CACTGAGCCGCCGCCGAGGATTCAGCAGCCTCCCCCTTGAGCCCCCTCGCTTCCCGACGTTCCGTTCCCCCCTGCCCGCCTTCTCCCGCC
ACCGCCGCCGCCGCCTTCCGCAGGCCGTTTCCACCGAGGAAAAGGAATCGTATCGTATGTCCGCTATCCAGAACCTCCACTCTTTCGATA
TTGATGATGTTAAGAAGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAA
ACCAGTTTGCTTTTAATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTA
TGAAGAAGTGTAATGGAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCAT
TAGTTGAATCGGTATCATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGA
AATTCTGCTGTCAAGATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTT

>25639_25639_5_EIF1-PPA2_EIF1_chr17_39845321_ENST00000469257_PPA2_chr4_106320321_ENST00000380004_length(amino acids)=174AA_BP=58
LSRRRGFSSLPLEPPRFPTFRSPLPAFSRHRRRRLPQAVSTEEKESYRMSAIQNLHSFDIDDVKKFKPGYLEATLNWFRLYKVPDGKPEN

--------------------------------------------------------------
>25639_25639_6_EIF1-PPA2_EIF1_chr17_39845321_ENST00000469257_PPA2_chr4_106320321_ENST00000432483_length(transcript)=687nt_BP=177nt
CACTGAGCCGCCGCCGAGGATTCAGCAGCCTCCCCCTTGAGCCCCCTCGCTTCCCGACGTTCCGTTCCCCCCTGCCCGCCTTCTCCCGCC
ACCGCCGCCGCCGCCTTCCGCAGGCCGTTTCCACCGAGGAAAAGGAATCGTATCGTATGTCCGCTATCCAGAACCTCCACTCTTTCGATA
TTGATGATGTTAAGAAGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAACCAGAAA
ACCAGTTTGCTTTTAATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTA
TGAAGAAGTGTAATGGAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAAGATCAT
TAGTTGAATCGGTATCATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAACATCTGA
AATTCTGCTGTCAAGATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTAAAACTT

>25639_25639_6_EIF1-PPA2_EIF1_chr17_39845321_ENST00000469257_PPA2_chr4_106320321_ENST00000432483_length(amino acids)=174AA_BP=58
LSRRRGFSSLPLEPPRFPTFRSPLPAFSRHRRRRLPQAVSTEEKESYRMSAIQNLHSFDIDDVKKFKPGYLEATLNWFRLYKVPDGKPEN

--------------------------------------------------------------
>25639_25639_7_EIF1-PPA2_EIF1_chr17_39845321_ENST00000591776_PPA2_chr4_106320321_ENST00000341695_length(transcript)=1181nt_BP=183nt
CCCAGTCACTGAGCCGCCGCCGAGGATTCAGCAGCCTCCCCCTTGAGCCCCCTCGCTTCCCGACGTTCCGTTCCCCCCTGCCCGCCTTCT
CCCGCCACCGCCGCCGCCGCCTTCCGCAGGCCGTTTCCACCGAGGAAAAGGAATCGTATCGTATGTCCGCTATCCAGAACCTCCACTCTT
TCGATATTGATGATGTTAAGAAGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAAC
CAGAAAACCAGTTTGCTTTTAATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCAT
TGCTTATGAAGAAGTGTAATGGAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAA
GATCATTAGTTGAATCGGTATCATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAAC
ATCTGAAATTCTGCTGTCAAGATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTA
AAACTTCATTTTTTCAAACTTTTTGAGCTATGCAATATATAAATAAACAGTAAGAATTTTAAATTACTCTCCTTTGGACATTTATTGATA
TAAAAAGAAGATTTTGGCCAGGCACGGTGGCTCATGCCTGTAATTTCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACAAGGTCAGGAG
TTCAAGACCAGCCTGGCCAGTATGTTGAAACCCCATCTCTATTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGCATGCCTGTAGACCC
AGCTACTCAGGAGGCTGAGGCAGAAGAACTGCTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGCAGAGATTGTGCCACTGCACTCCAGCCT
AGGCGACAGAGAGAGACTCCGTCTCAAAAAAAAAAAAAAGATTTTGTTTCATTTCATAGCACAAATTTAGAGGCATTGAGTTGACCATTT
CTAGTTTCTATACCTGAAGGAACCCATTGATTTTACCAGTTTTTATTTCTGTAGATTGGATGTAAAAATCACAGATTCAATAAATTAATA

>25639_25639_7_EIF1-PPA2_EIF1_chr17_39845321_ENST00000591776_PPA2_chr4_106320321_ENST00000341695_length(amino acids)=174AA_BP=58
MSRRRGFSSLPLEPPRFPTFRSPLPAFSRHRRRRLPQAVSTEEKESYRMSAIQNLHSFDIDDVKKFKPGYLEATLNWFRLYKVPDGKPEN

--------------------------------------------------------------
>25639_25639_8_EIF1-PPA2_EIF1_chr17_39845321_ENST00000591776_PPA2_chr4_106320321_ENST00000348706_length(transcript)=1015nt_BP=183nt
CCCAGTCACTGAGCCGCCGCCGAGGATTCAGCAGCCTCCCCCTTGAGCCCCCTCGCTTCCCGACGTTCCGTTCCCCCCTGCCCGCCTTCT
CCCGCCACCGCCGCCGCCGCCTTCCGCAGGCCGTTTCCACCGAGGAAAAGGAATCGTATCGTATGTCCGCTATCCAGAACCTCCACTCTT
TCGATATTGATGATGTTAAGAAGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAAC
CAGAAAACCAGTTTGCTTTTAATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCAT
TGCTTATGAAGAAGTGTAATGGAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAA
GATCATTAGTTGAATCGGTATCATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAAC
ATCTGAAATTCTGCTGTCAAGATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTA
AAACTTCATTTTTTCAAACTTTTTGAGCTATGCAATATATAAATAAACAGTAAGAATTTTAAATTACTCTCCTTTGGACATTTATTGATA
TAAAAAGAAGATTTTGGCCAGGCACGGTGGCTCATGCCTGTAATTTCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACAAGGTCAGGAG
TTCAAGACCAGCCTGGCCAGTATGTTGAAACCCCATCTCTATTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGCATGCCTGTAGACCC
AGCTACTCAGGAGGCTGAGGCAGAAGAACTGCTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGCAGAGATTGTGCCACTGCACTCCAGCCT

>25639_25639_8_EIF1-PPA2_EIF1_chr17_39845321_ENST00000591776_PPA2_chr4_106320321_ENST00000348706_length(amino acids)=174AA_BP=58
MSRRRGFSSLPLEPPRFPTFRSPLPAFSRHRRRRLPQAVSTEEKESYRMSAIQNLHSFDIDDVKKFKPGYLEATLNWFRLYKVPDGKPEN

--------------------------------------------------------------
>25639_25639_9_EIF1-PPA2_EIF1_chr17_39845321_ENST00000591776_PPA2_chr4_106320321_ENST00000354147_length(transcript)=693nt_BP=183nt
CCCAGTCACTGAGCCGCCGCCGAGGATTCAGCAGCCTCCCCCTTGAGCCCCCTCGCTTCCCGACGTTCCGTTCCCCCCTGCCCGCCTTCT
CCCGCCACCGCCGCCGCCGCCTTCCGCAGGCCGTTTCCACCGAGGAAAAGGAATCGTATCGTATGTCCGCTATCCAGAACCTCCACTCTT
TCGATATTGATGATGTTAAGAAGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAAC
CAGAAAACCAGTTTGCTTTTAATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCAT
TGCTTATGAAGAAGTGTAATGGAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAA
GATCATTAGTTGAATCGGTATCATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAAC
ATCTGAAATTCTGCTGTCAAGATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTA

>25639_25639_9_EIF1-PPA2_EIF1_chr17_39845321_ENST00000591776_PPA2_chr4_106320321_ENST00000354147_length(amino acids)=174AA_BP=58
MSRRRGFSSLPLEPPRFPTFRSPLPAFSRHRRRRLPQAVSTEEKESYRMSAIQNLHSFDIDDVKKFKPGYLEATLNWFRLYKVPDGKPEN

--------------------------------------------------------------
>25639_25639_10_EIF1-PPA2_EIF1_chr17_39845321_ENST00000591776_PPA2_chr4_106320321_ENST00000357415_length(transcript)=690nt_BP=183nt
CCCAGTCACTGAGCCGCCGCCGAGGATTCAGCAGCCTCCCCCTTGAGCCCCCTCGCTTCCCGACGTTCCGTTCCCCCCTGCCCGCCTTCT
CCCGCCACCGCCGCCGCCGCCTTCCGCAGGCCGTTTCCACCGAGGAAAAGGAATCGTATCGTATGTCCGCTATCCAGAACCTCCACTCTT
TCGATATTGATGATGTTAAGAAGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAAC
CAGAAAACCAGTTTGCTTTTAATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCAT
TGCTTATGAAGAAGTGTAATGGAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAA
GATCATTAGTTGAATCGGTATCATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAAC
ATCTGAAATTCTGCTGTCAAGATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTA

>25639_25639_10_EIF1-PPA2_EIF1_chr17_39845321_ENST00000591776_PPA2_chr4_106320321_ENST00000357415_length(amino acids)=174AA_BP=58
MSRRRGFSSLPLEPPRFPTFRSPLPAFSRHRRRRLPQAVSTEEKESYRMSAIQNLHSFDIDDVKKFKPGYLEATLNWFRLYKVPDGKPEN

--------------------------------------------------------------
>25639_25639_11_EIF1-PPA2_EIF1_chr17_39845321_ENST00000591776_PPA2_chr4_106320321_ENST00000380004_length(transcript)=690nt_BP=183nt
CCCAGTCACTGAGCCGCCGCCGAGGATTCAGCAGCCTCCCCCTTGAGCCCCCTCGCTTCCCGACGTTCCGTTCCCCCCTGCCCGCCTTCT
CCCGCCACCGCCGCCGCCGCCTTCCGCAGGCCGTTTCCACCGAGGAAAAGGAATCGTATCGTATGTCCGCTATCCAGAACCTCCACTCTT
TCGATATTGATGATGTTAAGAAGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAAC
CAGAAAACCAGTTTGCTTTTAATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCAT
TGCTTATGAAGAAGTGTAATGGAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAA
GATCATTAGTTGAATCGGTATCATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAAC
ATCTGAAATTCTGCTGTCAAGATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTA

>25639_25639_11_EIF1-PPA2_EIF1_chr17_39845321_ENST00000591776_PPA2_chr4_106320321_ENST00000380004_length(amino acids)=174AA_BP=58
MSRRRGFSSLPLEPPRFPTFRSPLPAFSRHRRRRLPQAVSTEEKESYRMSAIQNLHSFDIDDVKKFKPGYLEATLNWFRLYKVPDGKPEN

--------------------------------------------------------------
>25639_25639_12_EIF1-PPA2_EIF1_chr17_39845321_ENST00000591776_PPA2_chr4_106320321_ENST00000432483_length(transcript)=693nt_BP=183nt
CCCAGTCACTGAGCCGCCGCCGAGGATTCAGCAGCCTCCCCCTTGAGCCCCCTCGCTTCCCGACGTTCCGTTCCCCCCTGCCCGCCTTCT
CCCGCCACCGCCGCCGCCGCCTTCCGCAGGCCGTTTCCACCGAGGAAAAGGAATCGTATCGTATGTCCGCTATCCAGAACCTCCACTCTT
TCGATATTGATGATGTTAAGAAGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTATATAAGGTACCAGATGGAAAAC
CAGAAAACCAGTTTGCTTTTAATGGAGAATTCAAAAACAAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCAT
TGCTTATGAAGAAGTGTAATGGAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTCCGTTGCACTCAAGAGGAAGCAA
GATCATTAGTTGAATCGGTATCATCTTCACCAAATAAAGAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGATTGAAAC
ATCTGAAATTCTGCTGTCAAGATTCCCATCTCTAAGGACTCCAAGTGCTAGAGACAAGGGGGTCTATGAGCATTTACTGACTTCCTGTTA

>25639_25639_12_EIF1-PPA2_EIF1_chr17_39845321_ENST00000591776_PPA2_chr4_106320321_ENST00000432483_length(amino acids)=174AA_BP=58
MSRRRGFSSLPLEPPRFPTFRSPLPAFSRHRRRRLPQAVSTEEKESYRMSAIQNLHSFDIDDVKKFKPGYLEATLNWFRLYKVPDGKPEN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EIF1-PPA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EIF1-PPA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EIF1-PPA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC4310663SUDDEN CARDIAC FAILURE, ALCOHOL-INDUCED2CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC4310664SUDDEN CARDIAC FAILURE, INFANTILE2CTD_human;GENOMICS_ENGLAND;UNIPROT