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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CDK6-KLC1 (FusionGDB2 ID:HG1021TG3831) |
Fusion Gene Summary for CDK6-KLC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDK6-KLC1 | Fusion gene ID: hg1021tg3831 | Hgene | Tgene | Gene symbol | CDK6 | KLC1 | Gene ID | 1021 | 3831 |
| Gene name | cyclin dependent kinase 6 | kinesin light chain 1 | |
| Synonyms | MCPH12|PLSTIRE | KLC|KNS2|KNS2A | |
| Cytomap | ('CDK6')('KLC1') 7q21.2 | 14q32.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclin-dependent kinase 6cell division protein kinase 6serine/threonine-protein kinase PLSTIRE | kinesin light chain 1kinesin 2 60/70kDamedulloblastoma antigen MU-MB-2.50 | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | Q00534 | Q07866 | |
| Ensembl transtripts involved in fusion gene | ENST00000265734, ENST00000424848, ENST00000491250, | ||
| Fusion gene scores | * DoF score | 12 X 9 X 7=756 | 20 X 16 X 10=3200 |
| # samples | 17 | 22 | |
| ** MAII score | log2(17/756*10)=-2.15285148808337 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(22/3200*10)=-3.86249647625007 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CDK6 [Title/Abstract] AND KLC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CDK6(92377348)-KLC1(104152201), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CDK6 | GO:0001954 | positive regulation of cell-matrix adhesion | 10205165 |
| Hgene | CDK6 | GO:0003323 | type B pancreatic cell development | 20668294 |
| Hgene | CDK6 | GO:0006468 | protein phosphorylation | 8114739 |
| Hgene | CDK6 | GO:0010468 | regulation of gene expression | 15254224 |
| Hgene | CDK6 | GO:0045638 | negative regulation of myeloid cell differentiation | 17431401 |
| Hgene | CDK6 | GO:0045656 | negative regulation of monocyte differentiation | 26542173 |
| Hgene | CDK6 | GO:0045668 | negative regulation of osteoblast differentiation | 15254224 |
| Hgene | CDK6 | GO:0045786 | negative regulation of cell cycle | 14985467 |
| Hgene | CDK6 | GO:2000773 | negative regulation of cellular senescence | 17420273 |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for CDK6-KLC1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CDK6-KLC1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CDK6-KLC1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:92377348/:104152201) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDK6 | KLC1 |
| FUNCTION: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137, ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224, ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273, ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249, ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663, ECO:0000269|PubMed:8114739}. | FUNCTION: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CDK6-KLC1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for CDK6-KLC1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CDK6-KLC1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | CDK6 | Q00534 | DB09073 | Palbociclib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | CDK6 | Q00534 | DB09073 | Palbociclib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | CDK6 | Q00534 | DB11730 | Ribociclib | Antagonist|Inhibitor | Small molecule | Approved|Investigational |
| Hgene | CDK6 | Q00534 | DB11730 | Ribociclib | Antagonist|Inhibitor | Small molecule | Approved|Investigational |
| Hgene | CDK6 | Q00534 | DB12001 | Abemaciclib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | CDK6 | Q00534 | DB12001 | Abemaciclib | Inhibitor | Small molecule | Approved|Investigational |
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Related Diseases for CDK6-KLC1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CDK6 | C0004238 | Atrial Fibrillation | 2 | CTD_human |
| Hgene | CDK6 | C0025149 | Medulloblastoma | 2 | CTD_human |
| Hgene | CDK6 | C0205833 | Medullomyoblastoma | 2 | CTD_human |
| Hgene | CDK6 | C0235480 | Paroxysmal atrial fibrillation | 2 | CTD_human |
| Hgene | CDK6 | C0278510 | Childhood Medulloblastoma | 2 | CTD_human |
| Hgene | CDK6 | C0278876 | Adult Medulloblastoma | 2 | CTD_human |
| Hgene | CDK6 | C0751291 | Desmoplastic Medulloblastoma | 2 | CTD_human |
| Hgene | CDK6 | C1275668 | Melanotic medulloblastoma | 2 | CTD_human |
| Hgene | CDK6 | C2585653 | Persistent atrial fibrillation | 2 | CTD_human |
| Hgene | CDK6 | C3468561 | familial atrial fibrillation | 2 | CTD_human |
| Hgene | CDK6 | C0002871 | Anemia | 1 | CTD_human |
| Hgene | CDK6 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Hgene | CDK6 | C0004403 | Autosome Abnormalities | 1 | CTD_human |
| Hgene | CDK6 | C0008625 | Chromosome Aberrations | 1 | CTD_human |
| Hgene | CDK6 | C0017636 | Glioblastoma | 1 | CTD_human |
| Hgene | CDK6 | C0023452 | Childhood Acute Lymphoblastic Leukemia | 1 | CTD_human |
| Hgene | CDK6 | C0023453 | L2 Acute Lymphoblastic Leukemia | 1 | CTD_human |
| Hgene | CDK6 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Hgene | CDK6 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Hgene | CDK6 | C0026998 | Acute Myeloid Leukemia, M1 | 1 | CTD_human |
| Hgene | CDK6 | C0038454 | Cerebrovascular accident | 1 | CTD_human |
| Hgene | CDK6 | C0263454 | Chloracne | 1 | CTD_human |
| Hgene | CDK6 | C0334588 | Giant Cell Glioblastoma | 1 | CTD_human |
| Hgene | CDK6 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Hgene | CDK6 | C0677866 | Brain Stem Neoplasms | 1 | CTD_human |
| Hgene | CDK6 | C0751886 | Brain Stem Neoplasms, Primary | 1 | CTD_human |
| Hgene | CDK6 | C0751887 | Medullary Neoplasms | 1 | CTD_human |
| Hgene | CDK6 | C0751888 | Mesencephalic Neoplasms | 1 | CTD_human |
| Hgene | CDK6 | C0751889 | Pontine Tumors | 1 | CTD_human |
| Hgene | CDK6 | C0751956 | Acute Cerebrovascular Accidents | 1 | CTD_human |
| Hgene | CDK6 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
| Hgene | CDK6 | C1621958 | Glioblastoma Multiforme | 1 | CTD_human |
| Hgene | CDK6 | C1879321 | Acute Myeloid Leukemia (AML-M2) | 1 | CTD_human |
| Hgene | CDK6 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
| Hgene | CDK6 | C3711387 | Autosomal Recessive Primary Microcephaly | 1 | ORPHANET |
| Hgene | CDK6 | C4015156 | MICROCEPHALY 12, PRIMARY, AUTOSOMAL RECESSIVE | 1 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
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