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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AP3S2-CERS3 (FusionGDB2 ID:HG10239TG204219)

Fusion Gene Summary for AP3S2-CERS3

check button Fusion gene summary
Fusion gene informationFusion gene name: AP3S2-CERS3
Fusion gene ID: hg10239tg204219
HgeneTgene
Gene symbol

AP3S2

CERS3

Gene ID

10239

204219

Gene nameadaptor related protein complex 3 subunit sigma 2ceramide synthase 3
SynonymsAP3S3|sigma3bARCI9|LASS3
Cytomap('AP3S2')('CERS3')

15q26.1

15q26.3

Type of geneprotein-codingprotein-coding
DescriptionAP-3 complex subunit sigma-2AP-3 complex subunit sigma-3Badapter-related protein complex 3 subunit sigma-2adaptor complex sigma3Badaptor related protein complex 3 sigma 2 subunitclathrin-associated/assembly/adaptor protein, small 4, 22-kDsigma-3B-adceramide synthase 3LAG1 homolog, ceramide synthase 3LAG1 longevity assurance homolog 3dihydroceramide synthase 3sphingosine N-acyltransferase CERS3
Modification date2020031320200313
UniProtAcc

P59780

.
Ensembl transtripts involved in fusion geneENST00000336418, ENST00000558011, 
ENST00000560940, ENST00000560771, 
Fusion gene scores* DoF score3 X 1 X 2=68 X 7 X 7=392
# samples 311
** MAII scorelog2(3/6*10)=2.32192809488736log2(11/392*10)=-1.83335013059055
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AP3S2 [Title/Abstract] AND CERS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAP3S2(90414707)-CERS3(101024873), # samples:1
Anticipated loss of major functional domain due to fusion event.AP3S2-CERS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AP3S2-CERS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AP3S2-CERS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AP3S2-CERS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCERS3

GO:0046513

ceramide biosynthetic process

17977534|22038835


check buttonFusion gene breakpoints across AP3S2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CERS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A1HI-01AAP3S2chr15

90414707

-CERS3chr15

101024873

-


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Fusion Gene ORF analysis for AP3S2-CERS3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336418ENST00000560944AP3S2chr15

90414707

-CERS3chr15

101024873

-
5CDS-intronENST00000558011ENST00000560944AP3S2chr15

90414707

-CERS3chr15

101024873

-
5CDS-intronENST00000560940ENST00000560944AP3S2chr15

90414707

-CERS3chr15

101024873

-
In-frameENST00000336418ENST00000284382AP3S2chr15

90414707

-CERS3chr15

101024873

-
In-frameENST00000336418ENST00000394113AP3S2chr15

90414707

-CERS3chr15

101024873

-
In-frameENST00000336418ENST00000538112AP3S2chr15

90414707

-CERS3chr15

101024873

-
In-frameENST00000558011ENST00000284382AP3S2chr15

90414707

-CERS3chr15

101024873

-
In-frameENST00000558011ENST00000394113AP3S2chr15

90414707

-CERS3chr15

101024873

-
In-frameENST00000558011ENST00000538112AP3S2chr15

90414707

-CERS3chr15

101024873

-
In-frameENST00000560940ENST00000284382AP3S2chr15

90414707

-CERS3chr15

101024873

-
In-frameENST00000560940ENST00000394113AP3S2chr15

90414707

-CERS3chr15

101024873

-
In-frameENST00000560940ENST00000538112AP3S2chr15

90414707

-CERS3chr15

101024873

-
intron-3CDSENST00000560771ENST00000284382AP3S2chr15

90414707

-CERS3chr15

101024873

-
intron-3CDSENST00000560771ENST00000394113AP3S2chr15

90414707

-CERS3chr15

101024873

-
intron-3CDSENST00000560771ENST00000538112AP3S2chr15

90414707

-CERS3chr15

101024873

-
intron-intronENST00000560771ENST00000560944AP3S2chr15

90414707

-CERS3chr15

101024873

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336418AP3S2chr1590414707-ENST00000284382CERS3chr15101024873-39207383691601410
ENST00000336418AP3S2chr1590414707-ENST00000538112CERS3chr15101024873-18047383691601410
ENST00000336418AP3S2chr1590414707-ENST00000394113CERS3chr15101024873-18047383691601410
ENST00000558011AP3S2chr1590414707-ENST00000284382CERS3chr15101024873-3608426211289422
ENST00000558011AP3S2chr1590414707-ENST00000538112CERS3chr15101024873-1492426211289422
ENST00000558011AP3S2chr1590414707-ENST00000394113CERS3chr15101024873-1492426211289422
ENST00000560940AP3S2chr1590414707-ENST00000284382CERS3chr15101024873-355937781240410
ENST00000560940AP3S2chr1590414707-ENST00000538112CERS3chr15101024873-144337781240410
ENST00000560940AP3S2chr1590414707-ENST00000394113CERS3chr15101024873-144337781240410

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336418ENST00000284382AP3S2chr1590414707-CERS3chr15101024873-0.0026858120.99731416
ENST00000336418ENST00000538112AP3S2chr1590414707-CERS3chr15101024873-0.0046447950.99535525
ENST00000336418ENST00000394113AP3S2chr1590414707-CERS3chr15101024873-0.0046447950.99535525
ENST00000558011ENST00000284382AP3S2chr1590414707-CERS3chr15101024873-0.0018745650.9981254
ENST00000558011ENST00000538112AP3S2chr1590414707-CERS3chr15101024873-0.0022653930.99773455
ENST00000558011ENST00000394113AP3S2chr1590414707-CERS3chr15101024873-0.0022653930.99773455
ENST00000560940ENST00000284382AP3S2chr1590414707-CERS3chr15101024873-0.0016900840.99830997
ENST00000560940ENST00000538112AP3S2chr1590414707-CERS3chr15101024873-0.0020347830.9979652
ENST00000560940ENST00000394113AP3S2chr1590414707-CERS3chr15101024873-0.0020347830.9979652

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Fusion Genomic Features for AP3S2-CERS3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AP3S2-CERS3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:90414707/chr15:101024873)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AP3S2

P59780

.
FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCERS3chr15:90414707chr15:101024873ENST00000284382413346_35596384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr15:90414707chr15:101024873ENST00000394113514346_35596384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr15:90414707chr15:101024873ENST00000538112413346_35596384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr15:90414707chr15:101024873ENST00000284382413130_33196384.0DomainTLC
TgeneCERS3chr15:90414707chr15:101024873ENST00000394113514130_33196384.0DomainTLC
TgeneCERS3chr15:90414707chr15:101024873ENST00000538112413130_33196384.0DomainTLC
TgeneCERS3chr15:90414707chr15:101024873ENST00000284382413319_38396384.0Topological domainCytoplasmic
TgeneCERS3chr15:90414707chr15:101024873ENST00000394113514319_38396384.0Topological domainCytoplasmic
TgeneCERS3chr15:90414707chr15:101024873ENST00000538112413319_38396384.0Topological domainCytoplasmic
TgeneCERS3chr15:90414707chr15:101024873ENST00000284382413139_15996384.0TransmembraneHelical
TgeneCERS3chr15:90414707chr15:101024873ENST00000284382413174_19496384.0TransmembraneHelical
TgeneCERS3chr15:90414707chr15:101024873ENST00000284382413205_22596384.0TransmembraneHelical
TgeneCERS3chr15:90414707chr15:101024873ENST00000284382413264_28496384.0TransmembraneHelical
TgeneCERS3chr15:90414707chr15:101024873ENST00000284382413298_31896384.0TransmembraneHelical
TgeneCERS3chr15:90414707chr15:101024873ENST00000394113514139_15996384.0TransmembraneHelical
TgeneCERS3chr15:90414707chr15:101024873ENST00000394113514174_19496384.0TransmembraneHelical
TgeneCERS3chr15:90414707chr15:101024873ENST00000394113514205_22596384.0TransmembraneHelical
TgeneCERS3chr15:90414707chr15:101024873ENST00000394113514264_28496384.0TransmembraneHelical
TgeneCERS3chr15:90414707chr15:101024873ENST00000394113514298_31896384.0TransmembraneHelical
TgeneCERS3chr15:90414707chr15:101024873ENST00000538112413139_15996384.0TransmembraneHelical
TgeneCERS3chr15:90414707chr15:101024873ENST00000538112413174_19496384.0TransmembraneHelical
TgeneCERS3chr15:90414707chr15:101024873ENST00000538112413205_22596384.0TransmembraneHelical
TgeneCERS3chr15:90414707chr15:101024873ENST00000538112413264_28496384.0TransmembraneHelical
TgeneCERS3chr15:90414707chr15:101024873ENST00000538112413298_31896384.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCERS3chr15:90414707chr15:101024873ENST0000028438241366_12796384.0RegionHomeobox-like
TgeneCERS3chr15:90414707chr15:101024873ENST0000039411351466_12796384.0RegionHomeobox-like
TgeneCERS3chr15:90414707chr15:101024873ENST0000053811241366_12796384.0RegionHomeobox-like
TgeneCERS3chr15:90414707chr15:101024873ENST0000028438241332_5296384.0TransmembraneHelical
TgeneCERS3chr15:90414707chr15:101024873ENST0000039411351432_5296384.0TransmembraneHelical
TgeneCERS3chr15:90414707chr15:101024873ENST0000053811241332_5296384.0TransmembraneHelical


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Fusion Gene Sequence for AP3S2-CERS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5301_5301_1_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000336418_CERS3_chr15_101024873_ENST00000284382_length(transcript)=3920nt_BP=738nt
ACGTTCTGCGAGCGCTAAGGGGATGGCGGGAGTGCATGATTTGGAGCGGGCGGTGAGAAAAGCAAGCTCCCGCCGCCTCTCCGTTTTGGC
AACCCGGCTGACGGTCGTTTCGGCTTCTGGGGCCAGCCGTCGGTCTGGGCGAGGGACATAGATCCGGATTCGCATCCTGACTGGCCAACC
AACGCTGGCCGAGGTGACCACTCTCCTCGGCATCCGCACCTGCCCTCCAAGGCGTCAGAGAGGCCGGACCCTTGGGTGCTAGGGCTCGTG
AGCGCCGGGGCCAAGTTTCCGAGTGCCGCTCTCAGCAGCGCACCAACCGGAAGTGATCGTGTTGTGGCGGAAGGAGGAGCTTTCTGGGAG
TAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTC
TACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTC
TTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCC
TCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTG
ATCTTCCATATGGATAAGACTGATATTTATGGACTGGCAAAGAAGTGTAACTTGACGGAGCGCCAGGTGGAAAGATGGTTTAGGAGTCGG
CGGAATCAAGAGAGGCCTTCCAGGCTGAAGAAATTCCAGGAAGCTTGCTGGAGATTTGCATTTTACTTAATGATCACTGTTGCTGGAATT
GCGTTTCTTTATGATAAACCTTGGCTATATGACTTATGGGAGGTTTGGAATGGCTATCCCAAACAGCCCCTGCTGCCATCCCAGTACTGG
TACTACATTTTAGAAATGAGTTTTTATTGGTCTCTGTTATTTAGACTTGGCTTTGATGTCAAGAGAAAGGATTTTCTAGCTCATATCATC
CACCACCTGGCTGCTATTAGTCTGATGAGCTTCTCTTGGTGTGCTAATTATATTCGCAGTGGGACCCTCGTGATGATTGTACACGATGTG
GCTGACATTTGGCTGGAGTCTGCTAAGATGTTTTCTTATGCTGGATGGACGCAGACCTGTAACACCCTGTTTTTCATCTTCTCCACCATA
TTTTTCATCAGCCGCCTCATTGTTTTTCCTTTCTGGATTTTATATTGCACGCTGATCTTGCCTATGTATCACCTCGAGCCTTTCTTTTCA
TACATCTTCCTCAACCTACAGCTCATGATCTTGCAGGTCCTTCACCTTTACTGGGGTTATTACATCTTGAAGATGCTCAACAGATGTATA
TTCATGAAGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAA
GAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACT
CCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACC
ACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTAACTTGTGTTAAAATGTTAAATATAAGCATGCCCATGGATTTTTAC
TGCAGTTAGGACTCAGACTGGTCAAAGATTTCAAAGATTTCTCCACAGAACCGTCTCAGTTCTAATTGCACTCCCTCATGCATGTCACTT
TCTCAGGGGCTCGCTTTGTTATAGACCCTTTCGCCTCGCCACCTTGCCTGTCCTCAGGACGCTTTCACAGGTGCTAAGTGATCTCATTTT
TCCCAGGTGTGTTTGGCCACAAAGAGCAGCTTCTTTCTCAAAATGAGTTAGAAGTGGCAGTGGGACAGGAGCGGAAGGACCACACCAGGA
GACACTTCCATCCTGAAGCTTAGGTGCCTCATCTCCACAGGGCGGTGGCAGTCCCTGCCTGCCACCCCACAGGGTTACAGCAAGGATTAA
GTGAGATCACAGAAGTTTAAGTACACACTGTCAACCGTGGGGTCATCGTGAACCAACCCACTTTGCACTGTTTGGGAGACAGAAACCTGG
CTAAACATGGCACTGCAATGGGCCTGAACAAAAGGCAGAATCTTTAAAAATTCCTCTTAAATGACTCTGGAGATACCTGGAAATGAAAGT
GCCAAGAAAGGTGTTCCATTTTATTTGCTAACTATTTATGCATTAGCTCCCCAAGGGTCATTCTCAGATTCTCCTGGAATTCTTCTCCCT
CAGGACCCATGGTTCAAGGAAGGAAGCTTAGGCCCTGTTCCTTCCTGTCCTTTGCTGGTCTTTCCCTTTTTTCCTTTCTAGGAGGGAAGC
TTCTGTGCTGCTGCCCTGAGCCCTTCCTTCAGGCCAGCACAGTACCTGGGGACCTCCACGGGGGAATGGGATCCAGGCCAGGTTGCTTGC
TGAGCCTCATCACCCAGGAGGCCTGAGCCTCTGGGGAGGGCACGCATGTACACTGCCAGACCCAGGGGAGATCTTGGGAACAGAGGATGC
TACGTGATTTCCTCTGGCTTCCAACCCAATCAGCCTGCATCACAGTGAAACACAACACAAAAGGCCATAAAAGGCATACCCCTGAGAAAT
GTTTAAGGGCAGGTGCTAGAGTCAGTGCCAGCTCCCTGGGAGGAGGGATAGGGACGGGCAGATCAGTAGCCAGCTTGTCCTCACCCTCCG
GAAGGGAGCACCGGAGAAGACTTGCACACGTCCCTGCCTCCCTTGCGGCCTTGTCACCAGAGGGACACATCTCCTGGGCACAATGTGCAG
GGCTGACCTGGGAGACTTCTCAGGTGGCTGCTGGCTGAGGAGAGGCCAGGCCTTCCCAAGGAAGACCCTGAGTAAAATCTGCATCTGTCC
TCACCACCTGGCACAGTCTCTCATAACGGTCAGATTTTGTATGTTCATCCTATTTATTCAGGGGCTCGTACTAGAAAGCCACAGGAGAGG
TCGGCTTGTAGGGACTGGAAAATCAGCCCCAAGCAGAGCAGCTGCAGGGCCCCTGGAGCCGGAAGGACACTGCACAGAACAGACTGCGTT
ATTGTTATTTTTAAATAAAAATATACATTTGAAACCTTAAGGCTAAACAAAAATAAACAAAAAATCCTTTAGAATTCTTTCCACAACAAT
ATCTCTTTCTGAGAAATTGTTACAAACAAGGTCAGATTTTCTCTGTATAACATTTGCTTTTATGAGGACAATATCATATGCATTATATGC
ATAATATGATATTATAAATCAAAATGCCTGCACCCACTTTAGGGTATAGCTATTGACTTATTATTAATATTATATTATTATTATTTTGCT
GGAAGAAGGTCACACTAAGATATAATTTTTTATGTTTTCAGTTAACGGTATGCTTTCTTCTTTGCTTATTTGGTTTTTGTCTCTGTACCA
AATATCTTCTTGCTTAAGGTAGAAAAGTATTTGTTTACCTCTATCTCCAGTTTTTTTTCTTATTTGAATGTTGAAGGTAAAATTGATATA
CCAATTTTAACTATTTCTGATACAGCTGAAAGCACTAAACTACTTCATAAGAAGTAGATACTCATTTTTGTAACACTATTTAGGGCTTTT
GTGGTTAATTTTAAAGGAAACCACTCTTTCTACAGGAAACAAGGGCTCAGGATTCTTCAGATGACCTTATAAAAATGCAGTCCACAGTGC

>5301_5301_1_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000336418_CERS3_chr15_101024873_ENST00000284382_length(amino acids)=410AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFL
YDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADI
WLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMK

--------------------------------------------------------------
>5301_5301_2_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000336418_CERS3_chr15_101024873_ENST00000394113_length(transcript)=1804nt_BP=738nt
ACGTTCTGCGAGCGCTAAGGGGATGGCGGGAGTGCATGATTTGGAGCGGGCGGTGAGAAAAGCAAGCTCCCGCCGCCTCTCCGTTTTGGC
AACCCGGCTGACGGTCGTTTCGGCTTCTGGGGCCAGCCGTCGGTCTGGGCGAGGGACATAGATCCGGATTCGCATCCTGACTGGCCAACC
AACGCTGGCCGAGGTGACCACTCTCCTCGGCATCCGCACCTGCCCTCCAAGGCGTCAGAGAGGCCGGACCCTTGGGTGCTAGGGCTCGTG
AGCGCCGGGGCCAAGTTTCCGAGTGCCGCTCTCAGCAGCGCACCAACCGGAAGTGATCGTGTTGTGGCGGAAGGAGGAGCTTTCTGGGAG
TAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTC
TACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTC
TTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCC
TCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTG
ATCTTCCATATGGATAAGACTGATATTTATGGACTGGCAAAGAAGTGTAACTTGACGGAGCGCCAGGTGGAAAGATGGTTTAGGAGTCGG
CGGAATCAAGAGAGGCCTTCCAGGCTGAAGAAATTCCAGGAAGCTTGCTGGAGATTTGCATTTTACTTAATGATCACTGTTGCTGGAATT
GCGTTTCTTTATGATAAACCTTGGCTATATGACTTATGGGAGGTTTGGAATGGCTATCCCAAACAGCCCCTGCTGCCATCCCAGTACTGG
TACTACATTTTAGAAATGAGTTTTTATTGGTCTCTGTTATTTAGACTTGGCTTTGATGTCAAGAGAAAGGATTTTCTAGCTCATATCATC
CACCACCTGGCTGCTATTAGTCTGATGAGCTTCTCTTGGTGTGCTAATTATATTCGCAGTGGGACCCTCGTGATGATTGTACACGATGTG
GCTGACATTTGGCTGGAGTCTGCTAAGATGTTTTCTTATGCTGGATGGACGCAGACCTGTAACACCCTGTTTTTCATCTTCTCCACCATA
TTTTTCATCAGCCGCCTCATTGTTTTTCCTTTCTGGATTTTATATTGCACGCTGATCTTGCCTATGTATCACCTCGAGCCTTTCTTTTCA
TACATCTTCCTCAACCTACAGCTCATGATCTTGCAGGTCCTTCACCTTTACTGGGGTTATTACATCTTGAAGATGCTCAACAGATGTATA
TTCATGAAGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAA
GAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACT
CCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACC
ACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTAACTTGTGTTAAAATGTTAAATATAAGCATGCCCATGGATTTTTAC

>5301_5301_2_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000336418_CERS3_chr15_101024873_ENST00000394113_length(amino acids)=410AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFL
YDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADI
WLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMK

--------------------------------------------------------------
>5301_5301_3_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000336418_CERS3_chr15_101024873_ENST00000538112_length(transcript)=1804nt_BP=738nt
ACGTTCTGCGAGCGCTAAGGGGATGGCGGGAGTGCATGATTTGGAGCGGGCGGTGAGAAAAGCAAGCTCCCGCCGCCTCTCCGTTTTGGC
AACCCGGCTGACGGTCGTTTCGGCTTCTGGGGCCAGCCGTCGGTCTGGGCGAGGGACATAGATCCGGATTCGCATCCTGACTGGCCAACC
AACGCTGGCCGAGGTGACCACTCTCCTCGGCATCCGCACCTGCCCTCCAAGGCGTCAGAGAGGCCGGACCCTTGGGTGCTAGGGCTCGTG
AGCGCCGGGGCCAAGTTTCCGAGTGCCGCTCTCAGCAGCGCACCAACCGGAAGTGATCGTGTTGTGGCGGAAGGAGGAGCTTTCTGGGAG
TAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTC
TACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTC
TTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCC
TCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTG
ATCTTCCATATGGATAAGACTGATATTTATGGACTGGCAAAGAAGTGTAACTTGACGGAGCGCCAGGTGGAAAGATGGTTTAGGAGTCGG
CGGAATCAAGAGAGGCCTTCCAGGCTGAAGAAATTCCAGGAAGCTTGCTGGAGATTTGCATTTTACTTAATGATCACTGTTGCTGGAATT
GCGTTTCTTTATGATAAACCTTGGCTATATGACTTATGGGAGGTTTGGAATGGCTATCCCAAACAGCCCCTGCTGCCATCCCAGTACTGG
TACTACATTTTAGAAATGAGTTTTTATTGGTCTCTGTTATTTAGACTTGGCTTTGATGTCAAGAGAAAGGATTTTCTAGCTCATATCATC
CACCACCTGGCTGCTATTAGTCTGATGAGCTTCTCTTGGTGTGCTAATTATATTCGCAGTGGGACCCTCGTGATGATTGTACACGATGTG
GCTGACATTTGGCTGGAGTCTGCTAAGATGTTTTCTTATGCTGGATGGACGCAGACCTGTAACACCCTGTTTTTCATCTTCTCCACCATA
TTTTTCATCAGCCGCCTCATTGTTTTTCCTTTCTGGATTTTATATTGCACGCTGATCTTGCCTATGTATCACCTCGAGCCTTTCTTTTCA
TACATCTTCCTCAACCTACAGCTCATGATCTTGCAGGTCCTTCACCTTTACTGGGGTTATTACATCTTGAAGATGCTCAACAGATGTATA
TTCATGAAGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAA
GAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACT
CCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACC
ACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTAACTTGTGTTAAAATGTTAAATATAAGCATGCCCATGGATTTTTAC

>5301_5301_3_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000336418_CERS3_chr15_101024873_ENST00000538112_length(amino acids)=410AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFL
YDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADI
WLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMK

--------------------------------------------------------------
>5301_5301_4_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000558011_CERS3_chr15_101024873_ENST00000284382_length(transcript)=3608nt_BP=426nt
GCTTTCTGGGAGTAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGG
CTAGTCCGCTTCTACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAAC
ATCTGTAACTTCTTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTT
TGTGTGGATTCCTCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTACATCTGGAAGTTGTTTTCTTCATAGCTCCCAAGGTTTTT
GTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGATCTTCCATATGGATAAGACTGATATTTATGGACTGGCAAAG
AAGTGTAACTTGACGGAGCGCCAGGTGGAAAGATGGTTTAGGAGTCGGCGGAATCAAGAGAGGCCTTCCAGGCTGAAGAAATTCCAGGAA
GCTTGCTGGAGATTTGCATTTTACTTAATGATCACTGTTGCTGGAATTGCGTTTCTTTATGATAAACCTTGGCTATATGACTTATGGGAG
GTTTGGAATGGCTATCCCAAACAGCCCCTGCTGCCATCCCAGTACTGGTACTACATTTTAGAAATGAGTTTTTATTGGTCTCTGTTATTT
AGACTTGGCTTTGATGTCAAGAGAAAGGATTTTCTAGCTCATATCATCCACCACCTGGCTGCTATTAGTCTGATGAGCTTCTCTTGGTGT
GCTAATTATATTCGCAGTGGGACCCTCGTGATGATTGTACACGATGTGGCTGACATTTGGCTGGAGTCTGCTAAGATGTTTTCTTATGCT
GGATGGACGCAGACCTGTAACACCCTGTTTTTCATCTTCTCCACCATATTTTTCATCAGCCGCCTCATTGTTTTTCCTTTCTGGATTTTA
TATTGCACGCTGATCTTGCCTATGTATCACCTCGAGCCTTTCTTTTCATACATCTTCCTCAACCTACAGCTCATGATCTTGCAGGTCCTT
CACCTTTACTGGGGTTATTACATCTTGAAGATGCTCAACAGATGTATATTCATGAAGAGCATCCAGGATGTGAGGAGTGATGACGAGGAT
TATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCAC
CTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTCCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCT
TCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTG
TTAACTTGTGTTAAAATGTTAAATATAAGCATGCCCATGGATTTTTACTGCAGTTAGGACTCAGACTGGTCAAAGATTTCAAAGATTTCT
CCACAGAACCGTCTCAGTTCTAATTGCACTCCCTCATGCATGTCACTTTCTCAGGGGCTCGCTTTGTTATAGACCCTTTCGCCTCGCCAC
CTTGCCTGTCCTCAGGACGCTTTCACAGGTGCTAAGTGATCTCATTTTTCCCAGGTGTGTTTGGCCACAAAGAGCAGCTTCTTTCTCAAA
ATGAGTTAGAAGTGGCAGTGGGACAGGAGCGGAAGGACCACACCAGGAGACACTTCCATCCTGAAGCTTAGGTGCCTCATCTCCACAGGG
CGGTGGCAGTCCCTGCCTGCCACCCCACAGGGTTACAGCAAGGATTAAGTGAGATCACAGAAGTTTAAGTACACACTGTCAACCGTGGGG
TCATCGTGAACCAACCCACTTTGCACTGTTTGGGAGACAGAAACCTGGCTAAACATGGCACTGCAATGGGCCTGAACAAAAGGCAGAATC
TTTAAAAATTCCTCTTAAATGACTCTGGAGATACCTGGAAATGAAAGTGCCAAGAAAGGTGTTCCATTTTATTTGCTAACTATTTATGCA
TTAGCTCCCCAAGGGTCATTCTCAGATTCTCCTGGAATTCTTCTCCCTCAGGACCCATGGTTCAAGGAAGGAAGCTTAGGCCCTGTTCCT
TCCTGTCCTTTGCTGGTCTTTCCCTTTTTTCCTTTCTAGGAGGGAAGCTTCTGTGCTGCTGCCCTGAGCCCTTCCTTCAGGCCAGCACAG
TACCTGGGGACCTCCACGGGGGAATGGGATCCAGGCCAGGTTGCTTGCTGAGCCTCATCACCCAGGAGGCCTGAGCCTCTGGGGAGGGCA
CGCATGTACACTGCCAGACCCAGGGGAGATCTTGGGAACAGAGGATGCTACGTGATTTCCTCTGGCTTCCAACCCAATCAGCCTGCATCA
CAGTGAAACACAACACAAAAGGCCATAAAAGGCATACCCCTGAGAAATGTTTAAGGGCAGGTGCTAGAGTCAGTGCCAGCTCCCTGGGAG
GAGGGATAGGGACGGGCAGATCAGTAGCCAGCTTGTCCTCACCCTCCGGAAGGGAGCACCGGAGAAGACTTGCACACGTCCCTGCCTCCC
TTGCGGCCTTGTCACCAGAGGGACACATCTCCTGGGCACAATGTGCAGGGCTGACCTGGGAGACTTCTCAGGTGGCTGCTGGCTGAGGAG
AGGCCAGGCCTTCCCAAGGAAGACCCTGAGTAAAATCTGCATCTGTCCTCACCACCTGGCACAGTCTCTCATAACGGTCAGATTTTGTAT
GTTCATCCTATTTATTCAGGGGCTCGTACTAGAAAGCCACAGGAGAGGTCGGCTTGTAGGGACTGGAAAATCAGCCCCAAGCAGAGCAGC
TGCAGGGCCCCTGGAGCCGGAAGGACACTGCACAGAACAGACTGCGTTATTGTTATTTTTAAATAAAAATATACATTTGAAACCTTAAGG
CTAAACAAAAATAAACAAAAAATCCTTTAGAATTCTTTCCACAACAATATCTCTTTCTGAGAAATTGTTACAAACAAGGTCAGATTTTCT
CTGTATAACATTTGCTTTTATGAGGACAATATCATATGCATTATATGCATAATATGATATTATAAATCAAAATGCCTGCACCCACTTTAG
GGTATAGCTATTGACTTATTATTAATATTATATTATTATTATTTTGCTGGAAGAAGGTCACACTAAGATATAATTTTTTATGTTTTCAGT
TAACGGTATGCTTTCTTCTTTGCTTATTTGGTTTTTGTCTCTGTACCAAATATCTTCTTGCTTAAGGTAGAAAAGTATTTGTTTACCTCT
ATCTCCAGTTTTTTTTCTTATTTGAATGTTGAAGGTAAAATTGATATACCAATTTTAACTATTTCTGATACAGCTGAAAGCACTAAACTA
CTTCATAAGAAGTAGATACTCATTTTTGTAACACTATTTAGGGCTTTTGTGGTTAATTTTAAAGGAAACCACTCTTTCTACAGGAAACAA
GGGCTCAGGATTCTTCAGATGACCTTATAAAAATGCAGTCCACAGTGCTATCAATATTGTAACAGTAATGACTACAATAAAGCCAAAAGT

>5301_5301_4_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000558011_CERS3_chr15_101024873_ENST00000284382_length(amino acids)=422AA_BP=135
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVHLEVVFFIAPKVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAF
YLMITVAGIAFLYDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSG
TLVMIVHDVADIWLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYY

--------------------------------------------------------------
>5301_5301_5_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000558011_CERS3_chr15_101024873_ENST00000394113_length(transcript)=1492nt_BP=426nt
GCTTTCTGGGAGTAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGG
CTAGTCCGCTTCTACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAAC
ATCTGTAACTTCTTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTT
TGTGTGGATTCCTCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTACATCTGGAAGTTGTTTTCTTCATAGCTCCCAAGGTTTTT
GTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGATCTTCCATATGGATAAGACTGATATTTATGGACTGGCAAAG
AAGTGTAACTTGACGGAGCGCCAGGTGGAAAGATGGTTTAGGAGTCGGCGGAATCAAGAGAGGCCTTCCAGGCTGAAGAAATTCCAGGAA
GCTTGCTGGAGATTTGCATTTTACTTAATGATCACTGTTGCTGGAATTGCGTTTCTTTATGATAAACCTTGGCTATATGACTTATGGGAG
GTTTGGAATGGCTATCCCAAACAGCCCCTGCTGCCATCCCAGTACTGGTACTACATTTTAGAAATGAGTTTTTATTGGTCTCTGTTATTT
AGACTTGGCTTTGATGTCAAGAGAAAGGATTTTCTAGCTCATATCATCCACCACCTGGCTGCTATTAGTCTGATGAGCTTCTCTTGGTGT
GCTAATTATATTCGCAGTGGGACCCTCGTGATGATTGTACACGATGTGGCTGACATTTGGCTGGAGTCTGCTAAGATGTTTTCTTATGCT
GGATGGACGCAGACCTGTAACACCCTGTTTTTCATCTTCTCCACCATATTTTTCATCAGCCGCCTCATTGTTTTTCCTTTCTGGATTTTA
TATTGCACGCTGATCTTGCCTATGTATCACCTCGAGCCTTTCTTTTCATACATCTTCCTCAACCTACAGCTCATGATCTTGCAGGTCCTT
CACCTTTACTGGGGTTATTACATCTTGAAGATGCTCAACAGATGTATATTCATGAAGAGCATCCAGGATGTGAGGAGTGATGACGAGGAT
TATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCAC
CTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTCCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCT
TCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTG

>5301_5301_5_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000558011_CERS3_chr15_101024873_ENST00000394113_length(amino acids)=422AA_BP=135
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVHLEVVFFIAPKVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAF
YLMITVAGIAFLYDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSG
TLVMIVHDVADIWLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYY

--------------------------------------------------------------
>5301_5301_6_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000558011_CERS3_chr15_101024873_ENST00000538112_length(transcript)=1492nt_BP=426nt
GCTTTCTGGGAGTAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGG
CTAGTCCGCTTCTACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAAC
ATCTGTAACTTCTTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTT
TGTGTGGATTCCTCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTACATCTGGAAGTTGTTTTCTTCATAGCTCCCAAGGTTTTT
GTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGATCTTCCATATGGATAAGACTGATATTTATGGACTGGCAAAG
AAGTGTAACTTGACGGAGCGCCAGGTGGAAAGATGGTTTAGGAGTCGGCGGAATCAAGAGAGGCCTTCCAGGCTGAAGAAATTCCAGGAA
GCTTGCTGGAGATTTGCATTTTACTTAATGATCACTGTTGCTGGAATTGCGTTTCTTTATGATAAACCTTGGCTATATGACTTATGGGAG
GTTTGGAATGGCTATCCCAAACAGCCCCTGCTGCCATCCCAGTACTGGTACTACATTTTAGAAATGAGTTTTTATTGGTCTCTGTTATTT
AGACTTGGCTTTGATGTCAAGAGAAAGGATTTTCTAGCTCATATCATCCACCACCTGGCTGCTATTAGTCTGATGAGCTTCTCTTGGTGT
GCTAATTATATTCGCAGTGGGACCCTCGTGATGATTGTACACGATGTGGCTGACATTTGGCTGGAGTCTGCTAAGATGTTTTCTTATGCT
GGATGGACGCAGACCTGTAACACCCTGTTTTTCATCTTCTCCACCATATTTTTCATCAGCCGCCTCATTGTTTTTCCTTTCTGGATTTTA
TATTGCACGCTGATCTTGCCTATGTATCACCTCGAGCCTTTCTTTTCATACATCTTCCTCAACCTACAGCTCATGATCTTGCAGGTCCTT
CACCTTTACTGGGGTTATTACATCTTGAAGATGCTCAACAGATGTATATTCATGAAGAGCATCCAGGATGTGAGGAGTGATGACGAGGAT
TATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCAC
CTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTCCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCT
TCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTG

>5301_5301_6_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000558011_CERS3_chr15_101024873_ENST00000538112_length(amino acids)=422AA_BP=135
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVHLEVVFFIAPKVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAF
YLMITVAGIAFLYDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSG
TLVMIVHDVADIWLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYY

--------------------------------------------------------------
>5301_5301_7_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000560940_CERS3_chr15_101024873_ENST00000284382_length(transcript)=3559nt_BP=377nt
AGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTCT
ACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTCT
TGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCCT
CAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGA
TCTTCCATATGGATAAGACTGATATTTATGGACTGGCAAAGAAGTGTAACTTGACGGAGCGCCAGGTGGAAAGATGGTTTAGGAGTCGGC
GGAATCAAGAGAGGCCTTCCAGGCTGAAGAAATTCCAGGAAGCTTGCTGGAGATTTGCATTTTACTTAATGATCACTGTTGCTGGAATTG
CGTTTCTTTATGATAAACCTTGGCTATATGACTTATGGGAGGTTTGGAATGGCTATCCCAAACAGCCCCTGCTGCCATCCCAGTACTGGT
ACTACATTTTAGAAATGAGTTTTTATTGGTCTCTGTTATTTAGACTTGGCTTTGATGTCAAGAGAAAGGATTTTCTAGCTCATATCATCC
ACCACCTGGCTGCTATTAGTCTGATGAGCTTCTCTTGGTGTGCTAATTATATTCGCAGTGGGACCCTCGTGATGATTGTACACGATGTGG
CTGACATTTGGCTGGAGTCTGCTAAGATGTTTTCTTATGCTGGATGGACGCAGACCTGTAACACCCTGTTTTTCATCTTCTCCACCATAT
TTTTCATCAGCCGCCTCATTGTTTTTCCTTTCTGGATTTTATATTGCACGCTGATCTTGCCTATGTATCACCTCGAGCCTTTCTTTTCAT
ACATCTTCCTCAACCTACAGCTCATGATCTTGCAGGTCCTTCACCTTTACTGGGGTTATTACATCTTGAAGATGCTCAACAGATGTATAT
TCATGAAGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAG
AGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTC
CCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCA
CCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTAACTTGTGTTAAAATGTTAAATATAAGCATGCCCATGGATTTTTACT
GCAGTTAGGACTCAGACTGGTCAAAGATTTCAAAGATTTCTCCACAGAACCGTCTCAGTTCTAATTGCACTCCCTCATGCATGTCACTTT
CTCAGGGGCTCGCTTTGTTATAGACCCTTTCGCCTCGCCACCTTGCCTGTCCTCAGGACGCTTTCACAGGTGCTAAGTGATCTCATTTTT
CCCAGGTGTGTTTGGCCACAAAGAGCAGCTTCTTTCTCAAAATGAGTTAGAAGTGGCAGTGGGACAGGAGCGGAAGGACCACACCAGGAG
ACACTTCCATCCTGAAGCTTAGGTGCCTCATCTCCACAGGGCGGTGGCAGTCCCTGCCTGCCACCCCACAGGGTTACAGCAAGGATTAAG
TGAGATCACAGAAGTTTAAGTACACACTGTCAACCGTGGGGTCATCGTGAACCAACCCACTTTGCACTGTTTGGGAGACAGAAACCTGGC
TAAACATGGCACTGCAATGGGCCTGAACAAAAGGCAGAATCTTTAAAAATTCCTCTTAAATGACTCTGGAGATACCTGGAAATGAAAGTG
CCAAGAAAGGTGTTCCATTTTATTTGCTAACTATTTATGCATTAGCTCCCCAAGGGTCATTCTCAGATTCTCCTGGAATTCTTCTCCCTC
AGGACCCATGGTTCAAGGAAGGAAGCTTAGGCCCTGTTCCTTCCTGTCCTTTGCTGGTCTTTCCCTTTTTTCCTTTCTAGGAGGGAAGCT
TCTGTGCTGCTGCCCTGAGCCCTTCCTTCAGGCCAGCACAGTACCTGGGGACCTCCACGGGGGAATGGGATCCAGGCCAGGTTGCTTGCT
GAGCCTCATCACCCAGGAGGCCTGAGCCTCTGGGGAGGGCACGCATGTACACTGCCAGACCCAGGGGAGATCTTGGGAACAGAGGATGCT
ACGTGATTTCCTCTGGCTTCCAACCCAATCAGCCTGCATCACAGTGAAACACAACACAAAAGGCCATAAAAGGCATACCCCTGAGAAATG
TTTAAGGGCAGGTGCTAGAGTCAGTGCCAGCTCCCTGGGAGGAGGGATAGGGACGGGCAGATCAGTAGCCAGCTTGTCCTCACCCTCCGG
AAGGGAGCACCGGAGAAGACTTGCACACGTCCCTGCCTCCCTTGCGGCCTTGTCACCAGAGGGACACATCTCCTGGGCACAATGTGCAGG
GCTGACCTGGGAGACTTCTCAGGTGGCTGCTGGCTGAGGAGAGGCCAGGCCTTCCCAAGGAAGACCCTGAGTAAAATCTGCATCTGTCCT
CACCACCTGGCACAGTCTCTCATAACGGTCAGATTTTGTATGTTCATCCTATTTATTCAGGGGCTCGTACTAGAAAGCCACAGGAGAGGT
CGGCTTGTAGGGACTGGAAAATCAGCCCCAAGCAGAGCAGCTGCAGGGCCCCTGGAGCCGGAAGGACACTGCACAGAACAGACTGCGTTA
TTGTTATTTTTAAATAAAAATATACATTTGAAACCTTAAGGCTAAACAAAAATAAACAAAAAATCCTTTAGAATTCTTTCCACAACAATA
TCTCTTTCTGAGAAATTGTTACAAACAAGGTCAGATTTTCTCTGTATAACATTTGCTTTTATGAGGACAATATCATATGCATTATATGCA
TAATATGATATTATAAATCAAAATGCCTGCACCCACTTTAGGGTATAGCTATTGACTTATTATTAATATTATATTATTATTATTTTGCTG
GAAGAAGGTCACACTAAGATATAATTTTTTATGTTTTCAGTTAACGGTATGCTTTCTTCTTTGCTTATTTGGTTTTTGTCTCTGTACCAA
ATATCTTCTTGCTTAAGGTAGAAAAGTATTTGTTTACCTCTATCTCCAGTTTTTTTTCTTATTTGAATGTTGAAGGTAAAATTGATATAC
CAATTTTAACTATTTCTGATACAGCTGAAAGCACTAAACTACTTCATAAGAAGTAGATACTCATTTTTGTAACACTATTTAGGGCTTTTG
TGGTTAATTTTAAAGGAAACCACTCTTTCTACAGGAAACAAGGGCTCAGGATTCTTCAGATGACCTTATAAAAATGCAGTCCACAGTGCT

>5301_5301_7_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000560940_CERS3_chr15_101024873_ENST00000284382_length(amino acids)=410AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFL
YDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADI
WLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMK

--------------------------------------------------------------
>5301_5301_8_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000560940_CERS3_chr15_101024873_ENST00000394113_length(transcript)=1443nt_BP=377nt
AGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTCT
ACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTCT
TGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCCT
CAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGA
TCTTCCATATGGATAAGACTGATATTTATGGACTGGCAAAGAAGTGTAACTTGACGGAGCGCCAGGTGGAAAGATGGTTTAGGAGTCGGC
GGAATCAAGAGAGGCCTTCCAGGCTGAAGAAATTCCAGGAAGCTTGCTGGAGATTTGCATTTTACTTAATGATCACTGTTGCTGGAATTG
CGTTTCTTTATGATAAACCTTGGCTATATGACTTATGGGAGGTTTGGAATGGCTATCCCAAACAGCCCCTGCTGCCATCCCAGTACTGGT
ACTACATTTTAGAAATGAGTTTTTATTGGTCTCTGTTATTTAGACTTGGCTTTGATGTCAAGAGAAAGGATTTTCTAGCTCATATCATCC
ACCACCTGGCTGCTATTAGTCTGATGAGCTTCTCTTGGTGTGCTAATTATATTCGCAGTGGGACCCTCGTGATGATTGTACACGATGTGG
CTGACATTTGGCTGGAGTCTGCTAAGATGTTTTCTTATGCTGGATGGACGCAGACCTGTAACACCCTGTTTTTCATCTTCTCCACCATAT
TTTTCATCAGCCGCCTCATTGTTTTTCCTTTCTGGATTTTATATTGCACGCTGATCTTGCCTATGTATCACCTCGAGCCTTTCTTTTCAT
ACATCTTCCTCAACCTACAGCTCATGATCTTGCAGGTCCTTCACCTTTACTGGGGTTATTACATCTTGAAGATGCTCAACAGATGTATAT
TCATGAAGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAG
AGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTC
CCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCA
CCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTAACTTGTGTTAAAATGTTAAATATAAGCATGCCCATGGATTTTTACT

>5301_5301_8_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000560940_CERS3_chr15_101024873_ENST00000394113_length(amino acids)=410AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFL
YDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADI
WLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMK

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>5301_5301_9_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000560940_CERS3_chr15_101024873_ENST00000538112_length(transcript)=1443nt_BP=377nt
AGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTCT
ACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTCT
TGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCCT
CAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGA
TCTTCCATATGGATAAGACTGATATTTATGGACTGGCAAAGAAGTGTAACTTGACGGAGCGCCAGGTGGAAAGATGGTTTAGGAGTCGGC
GGAATCAAGAGAGGCCTTCCAGGCTGAAGAAATTCCAGGAAGCTTGCTGGAGATTTGCATTTTACTTAATGATCACTGTTGCTGGAATTG
CGTTTCTTTATGATAAACCTTGGCTATATGACTTATGGGAGGTTTGGAATGGCTATCCCAAACAGCCCCTGCTGCCATCCCAGTACTGGT
ACTACATTTTAGAAATGAGTTTTTATTGGTCTCTGTTATTTAGACTTGGCTTTGATGTCAAGAGAAAGGATTTTCTAGCTCATATCATCC
ACCACCTGGCTGCTATTAGTCTGATGAGCTTCTCTTGGTGTGCTAATTATATTCGCAGTGGGACCCTCGTGATGATTGTACACGATGTGG
CTGACATTTGGCTGGAGTCTGCTAAGATGTTTTCTTATGCTGGATGGACGCAGACCTGTAACACCCTGTTTTTCATCTTCTCCACCATAT
TTTTCATCAGCCGCCTCATTGTTTTTCCTTTCTGGATTTTATATTGCACGCTGATCTTGCCTATGTATCACCTCGAGCCTTTCTTTTCAT
ACATCTTCCTCAACCTACAGCTCATGATCTTGCAGGTCCTTCACCTTTACTGGGGTTATTACATCTTGAAGATGCTCAACAGATGTATAT
TCATGAAGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAG
AGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTC
CCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCA
CCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTAACTTGTGTTAAAATGTTAAATATAAGCATGCCCATGGATTTTTACT

>5301_5301_9_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000560940_CERS3_chr15_101024873_ENST00000538112_length(amino acids)=410AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFL
YDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADI
WLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMK

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Fusion Gene PPI Analysis for AP3S2-CERS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AP3S2-CERS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AP3S2-CERS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAP3S2C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneC3554349ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 92CTD_human;GENOMICS_ENGLAND
TgeneC0079154Congenital Nonbullous Ichthyosiform Erythroderma1ORPHANET
TgeneC2750787Weill-Marchesani-Like Syndrome1ORPHANET