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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GPHN-MPHOSPH8 (FusionGDB2 ID:HG10243TG54737)

Fusion Gene Summary for GPHN-MPHOSPH8

check button Fusion gene summary
Fusion gene informationFusion gene name: GPHN-MPHOSPH8
Fusion gene ID: hg10243tg54737
HgeneTgene
Gene symbol

GPHN

MPHOSPH8

Gene ID

10243

54737

Gene namegephyrinM-phase phosphoprotein 8
SynonymsGEPH|GPH|GPHRYN|HKPX1|MOCODCHSMPP8|TWA3|mpp8
Cytomap('GPHN')('MPHOSPH8')

14q23.3-q24.1

13q12.11

Type of geneprotein-codingprotein-coding
DescriptiongephyrinM-phase phosphoprotein 8M-phase phosphoprotein, mppM-phase phosphoprotein, mpp8two hybrid-associated protein 3 with RanBPM
Modification date2020031320200313
UniProtAcc

Q9NQX3

.
Ensembl transtripts involved in fusion geneENST00000305960, ENST00000315266, 
ENST00000459628, ENST00000478722, 
ENST00000543237, ENST00000544752, 
Fusion gene scores* DoF score38 X 33 X 10=1254025 X 17 X 10=4250
# samples 4030
** MAII scorelog2(40/12540*10)=-4.97039353791468
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/4250*10)=-3.82442843541655
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPHN [Title/Abstract] AND MPHOSPH8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGPHN(66975309)-MPHOSPH8(20233135), # samples:1
Anticipated loss of major functional domain due to fusion event.GPHN-MPHOSPH8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GPHN-MPHOSPH8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGPHN

GO:0032324

molybdopterin cofactor biosynthetic process

26613940

HgeneGPHN

GO:0097112

gamma-aminobutyric acid receptor clustering

26613940

TgeneMPHOSPH8

GO:0045814

negative regulation of gene expression, epigenetic

26022416|28581500|29211708

TgeneMPHOSPH8

GO:0090309

positive regulation of methylation-dependent chromatin silencing

28581500|29211708


check buttonFusion gene breakpoints across GPHN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MPHOSPH8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4MESOTCGA-MQ-A6BQ-01AGPHNchr14

66975309

+MPHOSPH8chr13

20233135

+


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Fusion Gene ORF analysis for GPHN-MPHOSPH8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000305960ENST00000496525GPHNchr14

66975309

+MPHOSPH8chr13

20233135

+
5CDS-intronENST00000315266ENST00000496525GPHNchr14

66975309

+MPHOSPH8chr13

20233135

+
5CDS-intronENST00000459628ENST00000496525GPHNchr14

66975309

+MPHOSPH8chr13

20233135

+
5CDS-intronENST00000478722ENST00000496525GPHNchr14

66975309

+MPHOSPH8chr13

20233135

+
5CDS-intronENST00000543237ENST00000496525GPHNchr14

66975309

+MPHOSPH8chr13

20233135

+
In-frameENST00000305960ENST00000361479GPHNchr14

66975309

+MPHOSPH8chr13

20233135

+
In-frameENST00000305960ENST00000414242GPHNchr14

66975309

+MPHOSPH8chr13

20233135

+
In-frameENST00000315266ENST00000361479GPHNchr14

66975309

+MPHOSPH8chr13

20233135

+
In-frameENST00000315266ENST00000414242GPHNchr14

66975309

+MPHOSPH8chr13

20233135

+
In-frameENST00000459628ENST00000361479GPHNchr14

66975309

+MPHOSPH8chr13

20233135

+
In-frameENST00000459628ENST00000414242GPHNchr14

66975309

+MPHOSPH8chr13

20233135

+
In-frameENST00000478722ENST00000361479GPHNchr14

66975309

+MPHOSPH8chr13

20233135

+
In-frameENST00000478722ENST00000414242GPHNchr14

66975309

+MPHOSPH8chr13

20233135

+
In-frameENST00000543237ENST00000361479GPHNchr14

66975309

+MPHOSPH8chr13

20233135

+
In-frameENST00000543237ENST00000414242GPHNchr14

66975309

+MPHOSPH8chr13

20233135

+
intron-3CDSENST00000544752ENST00000361479GPHNchr14

66975309

+MPHOSPH8chr13

20233135

+
intron-3CDSENST00000544752ENST00000414242GPHNchr14

66975309

+MPHOSPH8chr13

20233135

+
intron-intronENST00000544752ENST00000496525GPHNchr14

66975309

+MPHOSPH8chr13

20233135

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000315266GPHNchr1466975309+ENST00000414242MPHOSPH8chr1320233135+2213118510252212396
ENST00000315266GPHNchr1466975309+ENST00000361479MPHOSPH8chr1320233135+3776118510252191388
ENST00000478722GPHNchr1466975309+ENST00000414242MPHOSPH8chr1320233135+2213118510252212396
ENST00000478722GPHNchr1466975309+ENST00000361479MPHOSPH8chr1320233135+3776118510252191388
ENST00000459628GPHNchr1466975309+ENST00000414242MPHOSPH8chr1320233135+14824542941481395
ENST00000459628GPHNchr1466975309+ENST00000361479MPHOSPH8chr1320233135+30454542941460388
ENST00000543237GPHNchr1466975309+ENST00000414242MPHOSPH8chr1320233135+111688151115366
ENST00000543237GPHNchr1466975309+ENST00000361479MPHOSPH8chr1320233135+267988151094359
ENST00000305960GPHNchr1466975309+ENST00000414242MPHOSPH8chr1320233135+11077961106366
ENST00000305960GPHNchr1466975309+ENST00000361479MPHOSPH8chr1320233135+26707961085359

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000315266ENST00000414242GPHNchr1466975309+MPHOSPH8chr1320233135+0.0020145370.9979855
ENST00000315266ENST00000361479GPHNchr1466975309+MPHOSPH8chr1320233135+0.0008950030.9991049
ENST00000478722ENST00000414242GPHNchr1466975309+MPHOSPH8chr1320233135+0.0020145370.9979855
ENST00000478722ENST00000361479GPHNchr1466975309+MPHOSPH8chr1320233135+0.0008950030.9991049
ENST00000459628ENST00000414242GPHNchr1466975309+MPHOSPH8chr1320233135+0.0013350920.99866486
ENST00000459628ENST00000361479GPHNchr1466975309+MPHOSPH8chr1320233135+0.0005014520.9994985
ENST00000543237ENST00000414242GPHNchr1466975309+MPHOSPH8chr1320233135+0.0009697340.99903023
ENST00000543237ENST00000361479GPHNchr1466975309+MPHOSPH8chr1320233135+0.0003874580.9996126
ENST00000305960ENST00000414242GPHNchr1466975309+MPHOSPH8chr1320233135+0.0010061550.9989938
ENST00000305960ENST00000361479GPHNchr1466975309+MPHOSPH8chr1320233135+0.0004076050.99959236

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Fusion Genomic Features for GPHN-MPHOSPH8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GPHNchr1466975309+MPHOSPH8chr1320233134+0.0003115420.9996885
GPHNchr1466975309+MPHOSPH8chr1320233134+0.0003115420.9996885

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GPHN-MPHOSPH8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:66975309/chr13:20233135)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPHN

Q9NQX3

.
FUNCTION: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157, PubMed:26613940). {ECO:0000250|UniProtKB:Q03555, ECO:0000269|PubMed:25025157, ECO:0000269|PubMed:26613940}.; FUNCTION: Has also a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. {ECO:0000269|PubMed:26613940}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMPHOSPH8chr14:66975309chr13:20233135ENST00000361479414600_629525861.0RepeatNote=ANK 1
TgeneMPHOSPH8chr14:66975309chr13:20233135ENST00000361479414633_662525861.0RepeatNote=ANK 2
TgeneMPHOSPH8chr14:66975309chr13:20233135ENST00000361479414666_695525861.0RepeatNote=ANK 3
TgeneMPHOSPH8chr14:66975309chr13:20233135ENST00000361479414699_728525861.0RepeatNote=ANK 4
TgeneMPHOSPH8chr14:66975309chr13:20233135ENST00000414242413600_629525868.0RepeatNote=ANK 1
TgeneMPHOSPH8chr14:66975309chr13:20233135ENST00000414242413633_662525868.0RepeatNote=ANK 2
TgeneMPHOSPH8chr14:66975309chr13:20233135ENST00000414242413666_695525868.0RepeatNote=ANK 3
TgeneMPHOSPH8chr14:66975309chr13:20233135ENST00000414242413699_728525868.0RepeatNote=ANK 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPHNchr14:66975309chr13:20233135ENST00000315266+12214_16621737.0RegionNote=MPT Mo-transferase
HgeneGPHNchr14:66975309chr13:20233135ENST00000315266+122326_73621737.0RegionNote=MPT adenylyltransferase
HgeneGPHNchr14:66975309chr13:20233135ENST00000478722+12314_16621770.0RegionNote=MPT Mo-transferase
HgeneGPHNchr14:66975309chr13:20233135ENST00000478722+123326_73621770.0RegionNote=MPT adenylyltransferase
TgeneMPHOSPH8chr14:66975309chr13:20233135ENST00000361479414151_256525861.0Compositional biasNote=Lys-rich
TgeneMPHOSPH8chr14:66975309chr13:20233135ENST00000414242413151_256525868.0Compositional biasNote=Lys-rich
TgeneMPHOSPH8chr14:66975309chr13:20233135ENST0000036147941459_118525861.0DomainChromo
TgeneMPHOSPH8chr14:66975309chr13:20233135ENST0000041424241359_118525868.0DomainChromo
TgeneMPHOSPH8chr14:66975309chr13:20233135ENST0000036147941480_87525861.0RegionHistone H3K9me3 binding
TgeneMPHOSPH8chr14:66975309chr13:20233135ENST0000041424241380_87525868.0RegionHistone H3K9me3 binding


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Fusion Gene Sequence for GPHN-MPHOSPH8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>34257_34257_1_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000305960_MPHOSPH8_chr13_20233135_ENST00000361479_length(transcript)=2670nt_BP=79nt
ACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTGTCGGAGTCCTTACAGATGGCAGGCAG
CAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGCACCTTGATGGGAAAGATGAGAATTTT
GCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTACTGTAAAAGTTGCACTTAATTCAAAT
GAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCGGAGGGCAGGACGACCTCCTGCGACTC
CTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATGCTGCAGAGAAGAACTTTTTAACAACA
GTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCACTGATGAAGGCCTGTAAAAGAGGAAAT
TCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGAATAGTGCCCTGCACTTTGCGAAGCAG
TCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAGAAGAGACAATAAAGGATTACTTTGAA
GCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAGATTTTTCAACAGATTTCAATTACAAA
CCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGGGTAAAGAAGTTATTGCTCGGCTCTGT
GGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGGACAGTCATTTTGTTTACTCATTCAGCCCT
GTTGCAGGTCCCAATAAACTCTTCATAAGGTTGACAGAAGCACCCTCTGCCAAGGTTAAGTTGCTAATAGGTGCATACAGAGTGCAGCTG
CAGTGACCAAACAGAAGGGACTGGGCGGAGTTCTCTTCAGACCGATTCCTATACTCTCTTTGACAGCAGTTTGGAATTCTTCTAGCACAT
CTATGTAAAGTTTTGTCTGTAAACCTCTTGCAGTTAAGCCTGTTGTCTGTTGTAGTCTGTAAGATGCGACATAGCTGTGTCTGTGCCAGT
ATGCCGGAATCTCAGTGCAGTGTCCAGACTGCGTATTTCAGTTTTTCCACAATGTGGATAGTACATATGAGGATTATTTAAGAAAATTAA
AGACTTCACTTTCTTTTTTCTGGAGACGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGCGATCTCGGCTCACTGCAAGCTC
TGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGACACCCGCCATGGCACCCAGCTAATTTTGTAT
TTTTAGTAGAGATGGGGTTTATCCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCGCCCGCCTCGGCCTCCCAAAGTG
CTTGGATTACAGGCATGAGCCACCGCACCCAGCAAGAGTTATTTTCTTAACTTGAAATTTTCTACTAGCCCTGGTGAACTTCTGTGCTTA
AAAAAAAAAAAAAAAAAAGGAAAAATTCAGCTCTAAAACATTTGCTTACAGCAAGGGAGCCATGTTATATTCAAGTTACCCAAGCACCAA
ATAAAGTGTGGGTTTGCTGCCCTTGAAAGGGTTGGGAGGCCTGATCTTTTTCTAGTAGACAGTTGCCACACATTCCCCAAGCACAAAAGG
TGGAGATGGCAGTCACTTTGTAAATATGCTGTAGTCACTTATCATCTTTTCAAAGGGTAACAAGAGAATCTAAGATGTAGTAAGAATGTA
AACCAGTACACTATGAGACCTAAAAGAGAGTATTAAATGTGAACTTTTAGCAGAGCGTGGTGGCTCACACCTATAATCCCAGCGCTTTGG
AGGCTGAGGTTGGAGGATTGCTTAAGTCCAGGAGTTCAAGACCAGCCTGGGTAACATGGGGTGGAACAAGCCTGTAGTCCCAGATACTCA
GGAGGCTGAGGTGAAAGGATTGCTTGAGCCAGGGAGGTCAAGGCTGCAGTGAGCCGTGAAAGGCCACTGCACTCCAGCCTGAGTGACAGA
ATGAGACCTTGTCTCAAAAAAAAAAAAAAGTTTCTTGGAACCTATACGGTTTTTTTTTGTTTTTTTTTTTTGAAAAGCCAGACCTTGTGC
CCTTGTTTTGAACACCGACTGGGAAGATGGGGCTTAGGTAACAGCCAAACCTGGCTGTCAGCTGTGTGGGAGCCACCACCCTCTCTGGGA
AGAGTTCCTGCTTCTGTATGGCAAGCATAAATCAAGCTCAGTCTGGGTTATGGAGAAGTTGAAAATTGTTTTGTTCCTCATTAGTTTATA
ATTGTATGAAATACGATTTTAATGAAAACTTTTCAGAATTCACGTTTGTGTAGATATTTCAGAGAACCATTTTTACTTTACATCCTAAAA
CTGCCTTTTCCTATGGTTTTGTCAATAAAACACTATGATGTTGGTCTGTTTCCTTTTATA

>34257_34257_1_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000305960_MPHOSPH8_chr13_20233135_ENST00000361479_length(amino acids)=359AA_BP=24
MGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEE
YNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSD
IVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSTDFNYKPP
QNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAGPNKLFIRLTEAPSAKVKLLIGAYRVQLQ

--------------------------------------------------------------
>34257_34257_2_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000305960_MPHOSPH8_chr13_20233135_ENST00000414242_length(transcript)=1107nt_BP=79nt
ACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTGTCGGAGTCCTTACAGATGGCAGGCAG
CAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGCACCTTGATGGGAAAGATGAGAATTTT
GCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTACTGTAAAAGTTGCACTTAATTCAAAT
GAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCGGAGGGCAGGACGACCTCCTGCGACTC
CTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATGCTGCAGAGAAGAACTTTTTAACAACA
GTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCACTGATGAAGGCCTGTAAAAGAGGAAAT
TCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGAATAGTGCCCTGCACTTTGCGAAGCAG
TCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAGAAGAGACAATAAAGGATTACTTTGAA
GCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAGATTTTTCAACAGATTTCAATTACAAA
CCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGGGTAAAGAAGTTATTGCTCGGCTCTGT
GGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGACAGGGTCTCGCTCTGTTGTCCAGGCTGGA
GTGCAGTGGCGCGGATTACAGCTCACTGGAGTCTTGACTTCCCAGGCACAAGCAATCCTCCCACCTCAGCCTCCTAACTACCTGGGACTA
AAAATGCACGCCACCACATCCGGCTAA

>34257_34257_2_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000305960_MPHOSPH8_chr13_20233135_ENST00000414242_length(amino acids)=366AA_BP=323
MGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEE
YNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSD
IVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSTDFNYKPP
QNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLTGSRSVVQAGVQWRGLQLTGVLTSQAQAILPPQPPNYLGLKM
HATTSG

--------------------------------------------------------------
>34257_34257_3_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000315266_MPHOSPH8_chr13_20233135_ENST00000361479_length(transcript)=3776nt_BP=1185nt
AGCAGCGCTCATGGCGAAGAGGCTTAAGGCCACAAAACCGTGGGACAGCAGGAGGAAGAGAAGCCAGGTATCTCCACTCCAGCTGCCCTG
CCTCAGACTCCTCAGTTTCGCACGTGAGGATCGTCTTGCAGGCACTGACTGGAGATGGAATCCTAAAGCATAGGTGAAGCGGAAATCCTC
CTTCAGGGAGAGCCCACTGAGGAAGCCAGCGGCTAGCACGAGGCAGGACAGGATACCTCCCTCTTCGCCCACGGCGGCCTCTCTGTCATA
GTAGCCACCGTTCTGCCACTCATGCAGCTTTCTAAGACACCTCTCGGTTCCCCAGCGCTTTCAGTGGGGCGGCCGGCCATTCCCGAGGGT
TGCAAGAGGAGGCCCGGGGTGCTGAGCCAGCCTCGCTGCCCCCGCGTAGAAAGCCGGCCCGCCGGCGAGAGCCAGCCTAAGGCGCGGACA
ACCAACGAGGTGTCAGGCTCGGCAGGGGATTGCTTCTGTCTGGGGCCCGGCCGAGGTTGCGTTCGTGCCTCGCGCGCACACGCTCCGCGT
TCACTCAGCCAATCCGGTGCTACTCGCGCGCCCAGGAGCGATCCGCGGTCCTACTCAGGCTGGGCCGGCTCCTTCCCGCTCCCAATACTC
AGCACCCGAGCTCTCACTCCTCCCCTCACTCTCCACGAGTTCCACGCCTAGGGGTGTAGCTCCGCCCTTGTCCCCGAGTCCGCCCCCGCA
ACCTCCAGAGCGTGTGCTATCCTTTCCTCTCAGTCCTGCCATCTAGCTGCCTTGGGTCTCGCGCTCCGCAGAGCGTTCCGACACTCTCCG
GCCTCGTTCTGCCGCCTCCGCGCGCTCTCCCCGTGCGGCCACCGCGCCCCCCAAGCTTGCCTCCTTCTTGCCGGACTTGGGGCCGCGCGC
CCTGACTCCTTCCCCTCCCGCGGACCCGCGCACTCCCGGCGCGGCCTCTCCCCCACGCAGGCCACCGTGCACTCTGTGGCCTCCCCCTCC
TTCCCCGCTCTCCTCGCGCTTCTCTGGCTCCCTAGCTGTCGCGCTCTCCTCGGCGAGCGCGCTCCCGGCCCGCGCGCTCCGGGCTCCGGT
TTCTCCCGGCTCCTGTCAGTGCGGTGACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTG
TCGGAGTCCTTACAGATGGCAGGCAGCAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGC
ACCTTGATGGGAAAGATGAGAATTTTGCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTA
CTGTAAAAGTTGCACTTAATTCAAATGAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCG
GAGGGCAGGACGACCTCCTGCGACTCCTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATG
CTGCAGAGAAGAACTTTTTAACAACAGTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCAC
TGATGAAGGCCTGTAAAAGAGGAAATTCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGA
ATAGTGCCCTGCACTTTGCGAAGCAGTCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAG
AAGAGACAATAAAGGATTACTTTGAAGCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAG
ATTTTTCAACAGATTTCAATTACAAACCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGG
GTAAAGAAGTTATTGCTCGGCTCTGTGGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGGACA
GTCATTTTGTTTACTCATTCAGCCCTGTTGCAGGTCCCAATAAACTCTTCATAAGGTTGACAGAAGCACCCTCTGCCAAGGTTAAGTTGC
TAATAGGTGCATACAGAGTGCAGCTGCAGTGACCAAACAGAAGGGACTGGGCGGAGTTCTCTTCAGACCGATTCCTATACTCTCTTTGAC
AGCAGTTTGGAATTCTTCTAGCACATCTATGTAAAGTTTTGTCTGTAAACCTCTTGCAGTTAAGCCTGTTGTCTGTTGTAGTCTGTAAGA
TGCGACATAGCTGTGTCTGTGCCAGTATGCCGGAATCTCAGTGCAGTGTCCAGACTGCGTATTTCAGTTTTTCCACAATGTGGATAGTAC
ATATGAGGATTATTTAAGAAAATTAAAGACTTCACTTTCTTTTTTCTGGAGACGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATG
GTGCGATCTCGGCTCACTGCAAGCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGACACCC
GCCATGGCACCCAGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTATCCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGA
TCCGCCCGCCTCGGCCTCCCAAAGTGCTTGGATTACAGGCATGAGCCACCGCACCCAGCAAGAGTTATTTTCTTAACTTGAAATTTTCTA
CTAGCCCTGGTGAACTTCTGTGCTTAAAAAAAAAAAAAAAAAAAGGAAAAATTCAGCTCTAAAACATTTGCTTACAGCAAGGGAGCCATG
TTATATTCAAGTTACCCAAGCACCAAATAAAGTGTGGGTTTGCTGCCCTTGAAAGGGTTGGGAGGCCTGATCTTTTTCTAGTAGACAGTT
GCCACACATTCCCCAAGCACAAAAGGTGGAGATGGCAGTCACTTTGTAAATATGCTGTAGTCACTTATCATCTTTTCAAAGGGTAACAAG
AGAATCTAAGATGTAGTAAGAATGTAAACCAGTACACTATGAGACCTAAAAGAGAGTATTAAATGTGAACTTTTAGCAGAGCGTGGTGGC
TCACACCTATAATCCCAGCGCTTTGGAGGCTGAGGTTGGAGGATTGCTTAAGTCCAGGAGTTCAAGACCAGCCTGGGTAACATGGGGTGG
AACAAGCCTGTAGTCCCAGATACTCAGGAGGCTGAGGTGAAAGGATTGCTTGAGCCAGGGAGGTCAAGGCTGCAGTGAGCCGTGAAAGGC
CACTGCACTCCAGCCTGAGTGACAGAATGAGACCTTGTCTCAAAAAAAAAAAAAAGTTTCTTGGAACCTATACGGTTTTTTTTTGTTTTT
TTTTTTTGAAAAGCCAGACCTTGTGCCCTTGTTTTGAACACCGACTGGGAAGATGGGGCTTAGGTAACAGCCAAACCTGGCTGTCAGCTG
TGTGGGAGCCACCACCCTCTCTGGGAAGAGTTCCTGCTTCTGTATGGCAAGCATAAATCAAGCTCAGTCTGGGTTATGGAGAAGTTGAAA
ATTGTTTTGTTCCTCATTAGTTTATAATTGTATGAAATACGATTTTAATGAAAACTTTTCAGAATTCACGTTTGTGTAGATATTTCAGAG
AACCATTTTTACTTTACATCCTAAAACTGCCTTTTCCTATGGTTTTGTCAATAAAACACTATGATGTTGGTCTGTTTCCTTTTATA

>34257_34257_3_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000315266_MPHOSPH8_chr13_20233135_ENST00000361479_length(amino acids)=388AA_BP=53
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAAT
DAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAI
LLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARL
ALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAG
PNKLFIRLTEAPSAKVKLLIGAYRVQLQ

--------------------------------------------------------------
>34257_34257_4_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000315266_MPHOSPH8_chr13_20233135_ENST00000414242_length(transcript)=2213nt_BP=1185nt
AGCAGCGCTCATGGCGAAGAGGCTTAAGGCCACAAAACCGTGGGACAGCAGGAGGAAGAGAAGCCAGGTATCTCCACTCCAGCTGCCCTG
CCTCAGACTCCTCAGTTTCGCACGTGAGGATCGTCTTGCAGGCACTGACTGGAGATGGAATCCTAAAGCATAGGTGAAGCGGAAATCCTC
CTTCAGGGAGAGCCCACTGAGGAAGCCAGCGGCTAGCACGAGGCAGGACAGGATACCTCCCTCTTCGCCCACGGCGGCCTCTCTGTCATA
GTAGCCACCGTTCTGCCACTCATGCAGCTTTCTAAGACACCTCTCGGTTCCCCAGCGCTTTCAGTGGGGCGGCCGGCCATTCCCGAGGGT
TGCAAGAGGAGGCCCGGGGTGCTGAGCCAGCCTCGCTGCCCCCGCGTAGAAAGCCGGCCCGCCGGCGAGAGCCAGCCTAAGGCGCGGACA
ACCAACGAGGTGTCAGGCTCGGCAGGGGATTGCTTCTGTCTGGGGCCCGGCCGAGGTTGCGTTCGTGCCTCGCGCGCACACGCTCCGCGT
TCACTCAGCCAATCCGGTGCTACTCGCGCGCCCAGGAGCGATCCGCGGTCCTACTCAGGCTGGGCCGGCTCCTTCCCGCTCCCAATACTC
AGCACCCGAGCTCTCACTCCTCCCCTCACTCTCCACGAGTTCCACGCCTAGGGGTGTAGCTCCGCCCTTGTCCCCGAGTCCGCCCCCGCA
ACCTCCAGAGCGTGTGCTATCCTTTCCTCTCAGTCCTGCCATCTAGCTGCCTTGGGTCTCGCGCTCCGCAGAGCGTTCCGACACTCTCCG
GCCTCGTTCTGCCGCCTCCGCGCGCTCTCCCCGTGCGGCCACCGCGCCCCCCAAGCTTGCCTCCTTCTTGCCGGACTTGGGGCCGCGCGC
CCTGACTCCTTCCCCTCCCGCGGACCCGCGCACTCCCGGCGCGGCCTCTCCCCCACGCAGGCCACCGTGCACTCTGTGGCCTCCCCCTCC
TTCCCCGCTCTCCTCGCGCTTCTCTGGCTCCCTAGCTGTCGCGCTCTCCTCGGCGAGCGCGCTCCCGGCCCGCGCGCTCCGGGCTCCGGT
TTCTCCCGGCTCCTGTCAGTGCGGTGACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTG
TCGGAGTCCTTACAGATGGCAGGCAGCAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGC
ACCTTGATGGGAAAGATGAGAATTTTGCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTA
CTGTAAAAGTTGCACTTAATTCAAATGAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCG
GAGGGCAGGACGACCTCCTGCGACTCCTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATG
CTGCAGAGAAGAACTTTTTAACAACAGTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCAC
TGATGAAGGCCTGTAAAAGAGGAAATTCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGA
ATAGTGCCCTGCACTTTGCGAAGCAGTCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAG
AAGAGACAATAAAGGATTACTTTGAAGCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAG
ATTTTTCAACAGATTTCAATTACAAACCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGG
GTAAAGAAGTTATTGCTCGGCTCTGTGGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGACAG
GGTCTCGCTCTGTTGTCCAGGCTGGAGTGCAGTGGCGCGGATTACAGCTCACTGGAGTCTTGACTTCCCAGGCACAAGCAATCCTCCCAC
CTCAGCCTCCTAACTACCTGGGACTAAAAATGCACGCCACCACATCCGGCTAA

>34257_34257_4_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000315266_MPHOSPH8_chr13_20233135_ENST00000414242_length(amino acids)=396AA_BP=352
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAAT
DAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAI
LLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARL
ALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLTGSRSVVQAGVQW
RGLQLTGVLTSQAQAILPPQPPNYLGLKMHATTSGX

--------------------------------------------------------------
>34257_34257_5_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000459628_MPHOSPH8_chr13_20233135_ENST00000361479_length(transcript)=3045nt_BP=454nt
GTGTGCTATCCTTTCCTCTCAGTCCTGCCATCTAGCTGCCTTGGGTCTCGCGCTCCGCAGAGCGTTCCGACACTCTCCGGCCTCGTTCTG
CCGCCTCCGCGCGCTCTCCCCGTGCGGCCACCGCGCCCCCCAAGCTTGCCTCCTTCTTGCCGGACTTGGGGCCGCGCGCCCTGACTCCTT
CCCCTCCCGCGGACCCGCGCACTCCCGGCGCGGCCTCTCCCCCACGCAGGCCACCGTGCACTCTGTGGCCTCCCCCTCCTTCCCCGCTCT
CCTCGCGCTTCTCTGGCTCCCTAGCTGTCGCGCTCTCCTCGGCGAGCGCGCTCCCGGCCCGCGCGCTCCGGGCTCCGGTTTCTCCCGGCT
CCTGTCAGTGCGGTGACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTGTCGGAGTCCTT
ACAGATGGCAGGCAGCAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGCACCTTGATGGG
AAAGATGAGAATTTTGCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTACTGTAAAAGTT
GCACTTAATTCAAATGAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCGGAGGGCAGGAC
GACCTCCTGCGACTCCTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATGCTGCAGAGAAG
AACTTTTTAACAACAGTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCACTGATGAAGGCC
TGTAAAAGAGGAAATTCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGAATAGTGCCCTG
CACTTTGCGAAGCAGTCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAGAAGAGACAATA
AAGGATTACTTTGAAGCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAGATTTTTCAACA
GATTTCAATTACAAACCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGGGTAAAGAAGTT
ATTGCTCGGCTCTGTGGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGGACAGTCATTTTGTT
TACTCATTCAGCCCTGTTGCAGGTCCCAATAAACTCTTCATAAGGTTGACAGAAGCACCCTCTGCCAAGGTTAAGTTGCTAATAGGTGCA
TACAGAGTGCAGCTGCAGTGACCAAACAGAAGGGACTGGGCGGAGTTCTCTTCAGACCGATTCCTATACTCTCTTTGACAGCAGTTTGGA
ATTCTTCTAGCACATCTATGTAAAGTTTTGTCTGTAAACCTCTTGCAGTTAAGCCTGTTGTCTGTTGTAGTCTGTAAGATGCGACATAGC
TGTGTCTGTGCCAGTATGCCGGAATCTCAGTGCAGTGTCCAGACTGCGTATTTCAGTTTTTCCACAATGTGGATAGTACATATGAGGATT
ATTTAAGAAAATTAAAGACTTCACTTTCTTTTTTCTGGAGACGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGCGATCTCG
GCTCACTGCAAGCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGACACCCGCCATGGCACC
CAGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTATCCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCGCCCGCCT
CGGCCTCCCAAAGTGCTTGGATTACAGGCATGAGCCACCGCACCCAGCAAGAGTTATTTTCTTAACTTGAAATTTTCTACTAGCCCTGGT
GAACTTCTGTGCTTAAAAAAAAAAAAAAAAAAAGGAAAAATTCAGCTCTAAAACATTTGCTTACAGCAAGGGAGCCATGTTATATTCAAG
TTACCCAAGCACCAAATAAAGTGTGGGTTTGCTGCCCTTGAAAGGGTTGGGAGGCCTGATCTTTTTCTAGTAGACAGTTGCCACACATTC
CCCAAGCACAAAAGGTGGAGATGGCAGTCACTTTGTAAATATGCTGTAGTCACTTATCATCTTTTCAAAGGGTAACAAGAGAATCTAAGA
TGTAGTAAGAATGTAAACCAGTACACTATGAGACCTAAAAGAGAGTATTAAATGTGAACTTTTAGCAGAGCGTGGTGGCTCACACCTATA
ATCCCAGCGCTTTGGAGGCTGAGGTTGGAGGATTGCTTAAGTCCAGGAGTTCAAGACCAGCCTGGGTAACATGGGGTGGAACAAGCCTGT
AGTCCCAGATACTCAGGAGGCTGAGGTGAAAGGATTGCTTGAGCCAGGGAGGTCAAGGCTGCAGTGAGCCGTGAAAGGCCACTGCACTCC
AGCCTGAGTGACAGAATGAGACCTTGTCTCAAAAAAAAAAAAAAGTTTCTTGGAACCTATACGGTTTTTTTTTGTTTTTTTTTTTTGAAA
AGCCAGACCTTGTGCCCTTGTTTTGAACACCGACTGGGAAGATGGGGCTTAGGTAACAGCCAAACCTGGCTGTCAGCTGTGTGGGAGCCA
CCACCCTCTCTGGGAAGAGTTCCTGCTTCTGTATGGCAAGCATAAATCAAGCTCAGTCTGGGTTATGGAGAAGTTGAAAATTGTTTTGTT
CCTCATTAGTTTATAATTGTATGAAATACGATTTTAATGAAAACTTTTCAGAATTCACGTTTGTGTAGATATTTCAGAGAACCATTTTTA
CTTTACATCCTAAAACTGCCTTTTCCTATGGTTTTGTCAATAAAACACTATGATGTTGGTCTGTTTCCTTTTATA

>34257_34257_5_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000459628_MPHOSPH8_chr13_20233135_ENST00000361479_length(amino acids)=388AA_BP=53
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAAT
DAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAI
LLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARL
ALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAG
PNKLFIRLTEAPSAKVKLLIGAYRVQLQ

--------------------------------------------------------------
>34257_34257_6_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000459628_MPHOSPH8_chr13_20233135_ENST00000414242_length(transcript)=1482nt_BP=454nt
GTGTGCTATCCTTTCCTCTCAGTCCTGCCATCTAGCTGCCTTGGGTCTCGCGCTCCGCAGAGCGTTCCGACACTCTCCGGCCTCGTTCTG
CCGCCTCCGCGCGCTCTCCCCGTGCGGCCACCGCGCCCCCCAAGCTTGCCTCCTTCTTGCCGGACTTGGGGCCGCGCGCCCTGACTCCTT
CCCCTCCCGCGGACCCGCGCACTCCCGGCGCGGCCTCTCCCCCACGCAGGCCACCGTGCACTCTGTGGCCTCCCCCTCCTTCCCCGCTCT
CCTCGCGCTTCTCTGGCTCCCTAGCTGTCGCGCTCTCCTCGGCGAGCGCGCTCCCGGCCCGCGCGCTCCGGGCTCCGGTTTCTCCCGGCT
CCTGTCAGTGCGGTGACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTGTCGGAGTCCTT
ACAGATGGCAGGCAGCAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGCACCTTGATGGG
AAAGATGAGAATTTTGCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTACTGTAAAAGTT
GCACTTAATTCAAATGAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCGGAGGGCAGGAC
GACCTCCTGCGACTCCTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATGCTGCAGAGAAG
AACTTTTTAACAACAGTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCACTGATGAAGGCC
TGTAAAAGAGGAAATTCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGAATAGTGCCCTG
CACTTTGCGAAGCAGTCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAGAAGAGACAATA
AAGGATTACTTTGAAGCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAGATTTTTCAACA
GATTTCAATTACAAACCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGGGTAAAGAAGTT
ATTGCTCGGCTCTGTGGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGACAGGGTCTCGCTCT
GTTGTCCAGGCTGGAGTGCAGTGGCGCGGATTACAGCTCACTGGAGTCTTGACTTCCCAGGCACAAGCAATCCTCCCACCTCAGCCTCCT
AACTACCTGGGACTAAAAATGCACGCCACCACATCCGGCTAA

>34257_34257_6_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000459628_MPHOSPH8_chr13_20233135_ENST00000414242_length(amino acids)=395AA_BP=352
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAAT
DAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAI
LLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARL
ALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLTGSRSVVQAGVQW
RGLQLTGVLTSQAQAILPPQPPNYLGLKMHATTSG

--------------------------------------------------------------
>34257_34257_7_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000478722_MPHOSPH8_chr13_20233135_ENST00000361479_length(transcript)=3776nt_BP=1185nt
AGCAGCGCTCATGGCGAAGAGGCTTAAGGCCACAAAACCGTGGGACAGCAGGAGGAAGAGAAGCCAGGTATCTCCACTCCAGCTGCCCTG
CCTCAGACTCCTCAGTTTCGCACGTGAGGATCGTCTTGCAGGCACTGACTGGAGATGGAATCCTAAAGCATAGGTGAAGCGGAAATCCTC
CTTCAGGGAGAGCCCACTGAGGAAGCCAGCGGCTAGCACGAGGCAGGACAGGATACCTCCCTCTTCGCCCACGGCGGCCTCTCTGTCATA
GTAGCCACCGTTCTGCCACTCATGCAGCTTTCTAAGACACCTCTCGGTTCCCCAGCGCTTTCAGTGGGGCGGCCGGCCATTCCCGAGGGT
TGCAAGAGGAGGCCCGGGGTGCTGAGCCAGCCTCGCTGCCCCCGCGTAGAAAGCCGGCCCGCCGGCGAGAGCCAGCCTAAGGCGCGGACA
ACCAACGAGGTGTCAGGCTCGGCAGGGGATTGCTTCTGTCTGGGGCCCGGCCGAGGTTGCGTTCGTGCCTCGCGCGCACACGCTCCGCGT
TCACTCAGCCAATCCGGTGCTACTCGCGCGCCCAGGAGCGATCCGCGGTCCTACTCAGGCTGGGCCGGCTCCTTCCCGCTCCCAATACTC
AGCACCCGAGCTCTCACTCCTCCCCTCACTCTCCACGAGTTCCACGCCTAGGGGTGTAGCTCCGCCCTTGTCCCCGAGTCCGCCCCCGCA
ACCTCCAGAGCGTGTGCTATCCTTTCCTCTCAGTCCTGCCATCTAGCTGCCTTGGGTCTCGCGCTCCGCAGAGCGTTCCGACACTCTCCG
GCCTCGTTCTGCCGCCTCCGCGCGCTCTCCCCGTGCGGCCACCGCGCCCCCCAAGCTTGCCTCCTTCTTGCCGGACTTGGGGCCGCGCGC
CCTGACTCCTTCCCCTCCCGCGGACCCGCGCACTCCCGGCGCGGCCTCTCCCCCACGCAGGCCACCGTGCACTCTGTGGCCTCCCCCTCC
TTCCCCGCTCTCCTCGCGCTTCTCTGGCTCCCTAGCTGTCGCGCTCTCCTCGGCGAGCGCGCTCCCGGCCCGCGCGCTCCGGGCTCCGGT
TTCTCCCGGCTCCTGTCAGTGCGGTGACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTG
TCGGAGTCCTTACAGATGGCAGGCAGCAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGC
ACCTTGATGGGAAAGATGAGAATTTTGCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTA
CTGTAAAAGTTGCACTTAATTCAAATGAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCG
GAGGGCAGGACGACCTCCTGCGACTCCTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATG
CTGCAGAGAAGAACTTTTTAACAACAGTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCAC
TGATGAAGGCCTGTAAAAGAGGAAATTCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGA
ATAGTGCCCTGCACTTTGCGAAGCAGTCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAG
AAGAGACAATAAAGGATTACTTTGAAGCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAG
ATTTTTCAACAGATTTCAATTACAAACCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGG
GTAAAGAAGTTATTGCTCGGCTCTGTGGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGGACA
GTCATTTTGTTTACTCATTCAGCCCTGTTGCAGGTCCCAATAAACTCTTCATAAGGTTGACAGAAGCACCCTCTGCCAAGGTTAAGTTGC
TAATAGGTGCATACAGAGTGCAGCTGCAGTGACCAAACAGAAGGGACTGGGCGGAGTTCTCTTCAGACCGATTCCTATACTCTCTTTGAC
AGCAGTTTGGAATTCTTCTAGCACATCTATGTAAAGTTTTGTCTGTAAACCTCTTGCAGTTAAGCCTGTTGTCTGTTGTAGTCTGTAAGA
TGCGACATAGCTGTGTCTGTGCCAGTATGCCGGAATCTCAGTGCAGTGTCCAGACTGCGTATTTCAGTTTTTCCACAATGTGGATAGTAC
ATATGAGGATTATTTAAGAAAATTAAAGACTTCACTTTCTTTTTTCTGGAGACGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATG
GTGCGATCTCGGCTCACTGCAAGCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGACACCC
GCCATGGCACCCAGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTATCCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGA
TCCGCCCGCCTCGGCCTCCCAAAGTGCTTGGATTACAGGCATGAGCCACCGCACCCAGCAAGAGTTATTTTCTTAACTTGAAATTTTCTA
CTAGCCCTGGTGAACTTCTGTGCTTAAAAAAAAAAAAAAAAAAAGGAAAAATTCAGCTCTAAAACATTTGCTTACAGCAAGGGAGCCATG
TTATATTCAAGTTACCCAAGCACCAAATAAAGTGTGGGTTTGCTGCCCTTGAAAGGGTTGGGAGGCCTGATCTTTTTCTAGTAGACAGTT
GCCACACATTCCCCAAGCACAAAAGGTGGAGATGGCAGTCACTTTGTAAATATGCTGTAGTCACTTATCATCTTTTCAAAGGGTAACAAG
AGAATCTAAGATGTAGTAAGAATGTAAACCAGTACACTATGAGACCTAAAAGAGAGTATTAAATGTGAACTTTTAGCAGAGCGTGGTGGC
TCACACCTATAATCCCAGCGCTTTGGAGGCTGAGGTTGGAGGATTGCTTAAGTCCAGGAGTTCAAGACCAGCCTGGGTAACATGGGGTGG
AACAAGCCTGTAGTCCCAGATACTCAGGAGGCTGAGGTGAAAGGATTGCTTGAGCCAGGGAGGTCAAGGCTGCAGTGAGCCGTGAAAGGC
CACTGCACTCCAGCCTGAGTGACAGAATGAGACCTTGTCTCAAAAAAAAAAAAAAGTTTCTTGGAACCTATACGGTTTTTTTTTGTTTTT
TTTTTTTGAAAAGCCAGACCTTGTGCCCTTGTTTTGAACACCGACTGGGAAGATGGGGCTTAGGTAACAGCCAAACCTGGCTGTCAGCTG
TGTGGGAGCCACCACCCTCTCTGGGAAGAGTTCCTGCTTCTGTATGGCAAGCATAAATCAAGCTCAGTCTGGGTTATGGAGAAGTTGAAA
ATTGTTTTGTTCCTCATTAGTTTATAATTGTATGAAATACGATTTTAATGAAAACTTTTCAGAATTCACGTTTGTGTAGATATTTCAGAG
AACCATTTTTACTTTACATCCTAAAACTGCCTTTTCCTATGGTTTTGTCAATAAAACACTATGATGTTGGTCTGTTTCCTTTTATA

>34257_34257_7_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000478722_MPHOSPH8_chr13_20233135_ENST00000361479_length(amino acids)=388AA_BP=53
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAAT
DAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAI
LLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARL
ALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAG
PNKLFIRLTEAPSAKVKLLIGAYRVQLQ

--------------------------------------------------------------
>34257_34257_8_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000478722_MPHOSPH8_chr13_20233135_ENST00000414242_length(transcript)=2213nt_BP=1185nt
AGCAGCGCTCATGGCGAAGAGGCTTAAGGCCACAAAACCGTGGGACAGCAGGAGGAAGAGAAGCCAGGTATCTCCACTCCAGCTGCCCTG
CCTCAGACTCCTCAGTTTCGCACGTGAGGATCGTCTTGCAGGCACTGACTGGAGATGGAATCCTAAAGCATAGGTGAAGCGGAAATCCTC
CTTCAGGGAGAGCCCACTGAGGAAGCCAGCGGCTAGCACGAGGCAGGACAGGATACCTCCCTCTTCGCCCACGGCGGCCTCTCTGTCATA
GTAGCCACCGTTCTGCCACTCATGCAGCTTTCTAAGACACCTCTCGGTTCCCCAGCGCTTTCAGTGGGGCGGCCGGCCATTCCCGAGGGT
TGCAAGAGGAGGCCCGGGGTGCTGAGCCAGCCTCGCTGCCCCCGCGTAGAAAGCCGGCCCGCCGGCGAGAGCCAGCCTAAGGCGCGGACA
ACCAACGAGGTGTCAGGCTCGGCAGGGGATTGCTTCTGTCTGGGGCCCGGCCGAGGTTGCGTTCGTGCCTCGCGCGCACACGCTCCGCGT
TCACTCAGCCAATCCGGTGCTACTCGCGCGCCCAGGAGCGATCCGCGGTCCTACTCAGGCTGGGCCGGCTCCTTCCCGCTCCCAATACTC
AGCACCCGAGCTCTCACTCCTCCCCTCACTCTCCACGAGTTCCACGCCTAGGGGTGTAGCTCCGCCCTTGTCCCCGAGTCCGCCCCCGCA
ACCTCCAGAGCGTGTGCTATCCTTTCCTCTCAGTCCTGCCATCTAGCTGCCTTGGGTCTCGCGCTCCGCAGAGCGTTCCGACACTCTCCG
GCCTCGTTCTGCCGCCTCCGCGCGCTCTCCCCGTGCGGCCACCGCGCCCCCCAAGCTTGCCTCCTTCTTGCCGGACTTGGGGCCGCGCGC
CCTGACTCCTTCCCCTCCCGCGGACCCGCGCACTCCCGGCGCGGCCTCTCCCCCACGCAGGCCACCGTGCACTCTGTGGCCTCCCCCTCC
TTCCCCGCTCTCCTCGCGCTTCTCTGGCTCCCTAGCTGTCGCGCTCTCCTCGGCGAGCGCGCTCCCGGCCCGCGCGCTCCGGGCTCCGGT
TTCTCCCGGCTCCTGTCAGTGCGGTGACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTG
TCGGAGTCCTTACAGATGGCAGGCAGCAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGC
ACCTTGATGGGAAAGATGAGAATTTTGCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTA
CTGTAAAAGTTGCACTTAATTCAAATGAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCG
GAGGGCAGGACGACCTCCTGCGACTCCTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATG
CTGCAGAGAAGAACTTTTTAACAACAGTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCAC
TGATGAAGGCCTGTAAAAGAGGAAATTCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGA
ATAGTGCCCTGCACTTTGCGAAGCAGTCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAG
AAGAGACAATAAAGGATTACTTTGAAGCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAG
ATTTTTCAACAGATTTCAATTACAAACCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGG
GTAAAGAAGTTATTGCTCGGCTCTGTGGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGACAG
GGTCTCGCTCTGTTGTCCAGGCTGGAGTGCAGTGGCGCGGATTACAGCTCACTGGAGTCTTGACTTCCCAGGCACAAGCAATCCTCCCAC
CTCAGCCTCCTAACTACCTGGGACTAAAAATGCACGCCACCACATCCGGCTAA

>34257_34257_8_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000478722_MPHOSPH8_chr13_20233135_ENST00000414242_length(amino acids)=396AA_BP=352
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAAT
DAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAI
LLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARL
ALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLTGSRSVVQAGVQW
RGLQLTGVLTSQAQAILPPQPPNYLGLKMHATTSGX

--------------------------------------------------------------
>34257_34257_9_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000543237_MPHOSPH8_chr13_20233135_ENST00000361479_length(transcript)=2679nt_BP=88nt
AGTGCGGTGACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTGTCGGAGTCCTTACAGAT
GGCAGGCAGCAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGCACCTTGATGGGAAAGAT
GAGAATTTTGCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTACTGTAAAAGTTGCACTT
AATTCAAATGAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCGGAGGGCAGGACGACCTC
CTGCGACTCCTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATGCTGCAGAGAAGAACTTT
TTAACAACAGTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCACTGATGAAGGCCTGTAAA
AGAGGAAATTCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGAATAGTGCCCTGCACTTT
GCGAAGCAGTCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAGAAGAGACAATAAAGGAT
TACTTTGAAGCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAGATTTTTCAACAGATTTC
AATTACAAACCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGGGTAAAGAAGTTATTGCT
CGGCTCTGTGGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGGACAGTCATTTTGTTTACTCA
TTCAGCCCTGTTGCAGGTCCCAATAAACTCTTCATAAGGTTGACAGAAGCACCCTCTGCCAAGGTTAAGTTGCTAATAGGTGCATACAGA
GTGCAGCTGCAGTGACCAAACAGAAGGGACTGGGCGGAGTTCTCTTCAGACCGATTCCTATACTCTCTTTGACAGCAGTTTGGAATTCTT
CTAGCACATCTATGTAAAGTTTTGTCTGTAAACCTCTTGCAGTTAAGCCTGTTGTCTGTTGTAGTCTGTAAGATGCGACATAGCTGTGTC
TGTGCCAGTATGCCGGAATCTCAGTGCAGTGTCCAGACTGCGTATTTCAGTTTTTCCACAATGTGGATAGTACATATGAGGATTATTTAA
GAAAATTAAAGACTTCACTTTCTTTTTTCTGGAGACGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGCGATCTCGGCTCAC
TGCAAGCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGACACCCGCCATGGCACCCAGCTA
ATTTTGTATTTTTAGTAGAGATGGGGTTTATCCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCGCCCGCCTCGGCCT
CCCAAAGTGCTTGGATTACAGGCATGAGCCACCGCACCCAGCAAGAGTTATTTTCTTAACTTGAAATTTTCTACTAGCCCTGGTGAACTT
CTGTGCTTAAAAAAAAAAAAAAAAAAAGGAAAAATTCAGCTCTAAAACATTTGCTTACAGCAAGGGAGCCATGTTATATTCAAGTTACCC
AAGCACCAAATAAAGTGTGGGTTTGCTGCCCTTGAAAGGGTTGGGAGGCCTGATCTTTTTCTAGTAGACAGTTGCCACACATTCCCCAAG
CACAAAAGGTGGAGATGGCAGTCACTTTGTAAATATGCTGTAGTCACTTATCATCTTTTCAAAGGGTAACAAGAGAATCTAAGATGTAGT
AAGAATGTAAACCAGTACACTATGAGACCTAAAAGAGAGTATTAAATGTGAACTTTTAGCAGAGCGTGGTGGCTCACACCTATAATCCCA
GCGCTTTGGAGGCTGAGGTTGGAGGATTGCTTAAGTCCAGGAGTTCAAGACCAGCCTGGGTAACATGGGGTGGAACAAGCCTGTAGTCCC
AGATACTCAGGAGGCTGAGGTGAAAGGATTGCTTGAGCCAGGGAGGTCAAGGCTGCAGTGAGCCGTGAAAGGCCACTGCACTCCAGCCTG
AGTGACAGAATGAGACCTTGTCTCAAAAAAAAAAAAAAGTTTCTTGGAACCTATACGGTTTTTTTTTGTTTTTTTTTTTTGAAAAGCCAG
ACCTTGTGCCCTTGTTTTGAACACCGACTGGGAAGATGGGGCTTAGGTAACAGCCAAACCTGGCTGTCAGCTGTGTGGGAGCCACCACCC
TCTCTGGGAAGAGTTCCTGCTTCTGTATGGCAAGCATAAATCAAGCTCAGTCTGGGTTATGGAGAAGTTGAAAATTGTTTTGTTCCTCAT
TAGTTTATAATTGTATGAAATACGATTTTAATGAAAACTTTTCAGAATTCACGTTTGTGTAGATATTTCAGAGAACCATTTTTACTTTAC
ATCCTAAAACTGCCTTTTCCTATGGTTTTGTCAATAAAACACTATGATGTTGGTCTGTTTCCTTTTATA

>34257_34257_9_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000543237_MPHOSPH8_chr13_20233135_ENST00000361479_length(amino acids)=359AA_BP=24
MGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEE
YNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSD
IVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSTDFNYKPP
QNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAGPNKLFIRLTEAPSAKVKLLIGAYRVQLQ

--------------------------------------------------------------
>34257_34257_10_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000543237_MPHOSPH8_chr13_20233135_ENST00000414242_length(transcript)=1116nt_BP=88nt
AGTGCGGTGACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTGTCGGAGTCCTTACAGAT
GGCAGGCAGCAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGCACCTTGATGGGAAAGAT
GAGAATTTTGCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTACTGTAAAAGTTGCACTT
AATTCAAATGAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCGGAGGGCAGGACGACCTC
CTGCGACTCCTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATGCTGCAGAGAAGAACTTT
TTAACAACAGTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCACTGATGAAGGCCTGTAAA
AGAGGAAATTCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGAATAGTGCCCTGCACTTT
GCGAAGCAGTCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAGAAGAGACAATAAAGGAT
TACTTTGAAGCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAGATTTTTCAACAGATTTC
AATTACAAACCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGGGTAAAGAAGTTATTGCT
CGGCTCTGTGGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGACAGGGTCTCGCTCTGTTGTC
CAGGCTGGAGTGCAGTGGCGCGGATTACAGCTCACTGGAGTCTTGACTTCCCAGGCACAAGCAATCCTCCCACCTCAGCCTCCTAACTAC
CTGGGACTAAAAATGCACGCCACCACATCCGGCTAA

>34257_34257_10_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000543237_MPHOSPH8_chr13_20233135_ENST00000414242_length(amino acids)=366AA_BP=323
MGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEE
YNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSD
IVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSTDFNYKPP
QNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLTGSRSVVQAGVQWRGLQLTGVLTSQAQAILPPQPPNYLGLKM
HATTSG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GPHN-MPHOSPH8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneGPHNchr14:66975309chr13:20233135ENST00000315266+122140_31621.333333333333332737.0GABARAP
HgeneGPHNchr14:66975309chr13:20233135ENST00000478722+123140_31621.333333333333332770.0GABARAP


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GPHN-MPHOSPH8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGPHNQ9NQX3DB03766Propanoic acidSmall moleculeApproved|Vet_approved
HgeneGPHNQ9NQX3DB03766Propanoic acidSmall moleculeApproved|Vet_approved
HgeneGPHNQ9NQX3DB03766Propanoic acidSmall moleculeApproved|Vet_approved

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Related Diseases for GPHN-MPHOSPH8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGPHNC1854990Molybdenum Cofactor Deficiency, Complementation Group C5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneGPHNC0001956Alcohol Use Disorder1CTD_human
HgeneGPHNC0001973Alcoholic Intoxication, Chronic1CTD_human
HgeneGPHNC0009171Cocaine Abuse1CTD_human
HgeneGPHNC0085762Alcohol abuse1CTD_human
HgeneGPHNC0236736Cocaine-Related Disorders1CTD_human
HgeneGPHNC0543888Epileptic encephalopathy1GENOMICS_ENGLAND
HgeneGPHNC0600427Cocaine Dependence1CTD_human