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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:GPHN-MPHOSPH8 (FusionGDB2 ID:HG10243TG54737) |
Fusion Gene Summary for GPHN-MPHOSPH8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GPHN-MPHOSPH8 | Fusion gene ID: hg10243tg54737 | Hgene | Tgene | Gene symbol | GPHN | MPHOSPH8 | Gene ID | 10243 | 54737 |
| Gene name | gephyrin | M-phase phosphoprotein 8 | |
| Synonyms | GEPH|GPH|GPHRYN|HKPX1|MOCODC | HSMPP8|TWA3|mpp8 | |
| Cytomap | ('GPHN')('MPHOSPH8') 14q23.3-q24.1 | 13q12.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | gephyrin | M-phase phosphoprotein 8M-phase phosphoprotein, mppM-phase phosphoprotein, mpp8two hybrid-associated protein 3 with RanBPM | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9NQX3 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000305960, ENST00000315266, ENST00000459628, ENST00000478722, ENST00000543237, ENST00000544752, | ||
| Fusion gene scores | * DoF score | 38 X 33 X 10=12540 | 25 X 17 X 10=4250 |
| # samples | 40 | 30 | |
| ** MAII score | log2(40/12540*10)=-4.97039353791468 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(30/4250*10)=-3.82442843541655 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GPHN [Title/Abstract] AND MPHOSPH8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | GPHN(66975309)-MPHOSPH8(20233135), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | GPHN-MPHOSPH8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GPHN-MPHOSPH8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GPHN | GO:0032324 | molybdopterin cofactor biosynthetic process | 26613940 |
| Hgene | GPHN | GO:0097112 | gamma-aminobutyric acid receptor clustering | 26613940 |
| Tgene | MPHOSPH8 | GO:0045814 | negative regulation of gene expression, epigenetic | 26022416|28581500|29211708 |
| Tgene | MPHOSPH8 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing | 28581500|29211708 |
| Fusion gene breakpoints across GPHN (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MPHOSPH8 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | MESO | TCGA-MQ-A6BQ-01A | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + |
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Fusion Gene ORF analysis for GPHN-MPHOSPH8 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000305960 | ENST00000496525 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + |
| 5CDS-intron | ENST00000315266 | ENST00000496525 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + |
| 5CDS-intron | ENST00000459628 | ENST00000496525 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + |
| 5CDS-intron | ENST00000478722 | ENST00000496525 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + |
| 5CDS-intron | ENST00000543237 | ENST00000496525 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + |
| In-frame | ENST00000305960 | ENST00000361479 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + |
| In-frame | ENST00000305960 | ENST00000414242 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + |
| In-frame | ENST00000315266 | ENST00000361479 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + |
| In-frame | ENST00000315266 | ENST00000414242 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + |
| In-frame | ENST00000459628 | ENST00000361479 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + |
| In-frame | ENST00000459628 | ENST00000414242 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + |
| In-frame | ENST00000478722 | ENST00000361479 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + |
| In-frame | ENST00000478722 | ENST00000414242 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + |
| In-frame | ENST00000543237 | ENST00000361479 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + |
| In-frame | ENST00000543237 | ENST00000414242 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + |
| intron-3CDS | ENST00000544752 | ENST00000361479 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + |
| intron-3CDS | ENST00000544752 | ENST00000414242 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + |
| intron-intron | ENST00000544752 | ENST00000496525 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000315266 | GPHN | chr14 | 66975309 | + | ENST00000414242 | MPHOSPH8 | chr13 | 20233135 | + | 2213 | 1185 | 1025 | 2212 | 396 |
| ENST00000315266 | GPHN | chr14 | 66975309 | + | ENST00000361479 | MPHOSPH8 | chr13 | 20233135 | + | 3776 | 1185 | 1025 | 2191 | 388 |
| ENST00000478722 | GPHN | chr14 | 66975309 | + | ENST00000414242 | MPHOSPH8 | chr13 | 20233135 | + | 2213 | 1185 | 1025 | 2212 | 396 |
| ENST00000478722 | GPHN | chr14 | 66975309 | + | ENST00000361479 | MPHOSPH8 | chr13 | 20233135 | + | 3776 | 1185 | 1025 | 2191 | 388 |
| ENST00000459628 | GPHN | chr14 | 66975309 | + | ENST00000414242 | MPHOSPH8 | chr13 | 20233135 | + | 1482 | 454 | 294 | 1481 | 395 |
| ENST00000459628 | GPHN | chr14 | 66975309 | + | ENST00000361479 | MPHOSPH8 | chr13 | 20233135 | + | 3045 | 454 | 294 | 1460 | 388 |
| ENST00000543237 | GPHN | chr14 | 66975309 | + | ENST00000414242 | MPHOSPH8 | chr13 | 20233135 | + | 1116 | 88 | 15 | 1115 | 366 |
| ENST00000543237 | GPHN | chr14 | 66975309 | + | ENST00000361479 | MPHOSPH8 | chr13 | 20233135 | + | 2679 | 88 | 15 | 1094 | 359 |
| ENST00000305960 | GPHN | chr14 | 66975309 | + | ENST00000414242 | MPHOSPH8 | chr13 | 20233135 | + | 1107 | 79 | 6 | 1106 | 366 |
| ENST00000305960 | GPHN | chr14 | 66975309 | + | ENST00000361479 | MPHOSPH8 | chr13 | 20233135 | + | 2670 | 79 | 6 | 1085 | 359 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000315266 | ENST00000414242 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + | 0.002014537 | 0.9979855 |
| ENST00000315266 | ENST00000361479 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + | 0.000895003 | 0.9991049 |
| ENST00000478722 | ENST00000414242 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + | 0.002014537 | 0.9979855 |
| ENST00000478722 | ENST00000361479 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + | 0.000895003 | 0.9991049 |
| ENST00000459628 | ENST00000414242 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + | 0.001335092 | 0.99866486 |
| ENST00000459628 | ENST00000361479 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + | 0.000501452 | 0.9994985 |
| ENST00000543237 | ENST00000414242 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + | 0.000969734 | 0.99903023 |
| ENST00000543237 | ENST00000361479 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + | 0.000387458 | 0.9996126 |
| ENST00000305960 | ENST00000414242 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + | 0.001006155 | 0.9989938 |
| ENST00000305960 | ENST00000361479 | GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233135 | + | 0.000407605 | 0.99959236 |
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Fusion Genomic Features for GPHN-MPHOSPH8 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233134 | + | 0.000311542 | 0.9996885 |
| GPHN | chr14 | 66975309 | + | MPHOSPH8 | chr13 | 20233134 | + | 0.000311542 | 0.9996885 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for GPHN-MPHOSPH8 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:66975309/chr13:20233135) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GPHN | . |
| FUNCTION: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157, PubMed:26613940). {ECO:0000250|UniProtKB:Q03555, ECO:0000269|PubMed:25025157, ECO:0000269|PubMed:26613940}.; FUNCTION: Has also a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. {ECO:0000269|PubMed:26613940}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | MPHOSPH8 | chr14:66975309 | chr13:20233135 | ENST00000361479 | 4 | 14 | 600_629 | 525 | 861.0 | Repeat | Note=ANK 1 | |
| Tgene | MPHOSPH8 | chr14:66975309 | chr13:20233135 | ENST00000361479 | 4 | 14 | 633_662 | 525 | 861.0 | Repeat | Note=ANK 2 | |
| Tgene | MPHOSPH8 | chr14:66975309 | chr13:20233135 | ENST00000361479 | 4 | 14 | 666_695 | 525 | 861.0 | Repeat | Note=ANK 3 | |
| Tgene | MPHOSPH8 | chr14:66975309 | chr13:20233135 | ENST00000361479 | 4 | 14 | 699_728 | 525 | 861.0 | Repeat | Note=ANK 4 | |
| Tgene | MPHOSPH8 | chr14:66975309 | chr13:20233135 | ENST00000414242 | 4 | 13 | 600_629 | 525 | 868.0 | Repeat | Note=ANK 1 | |
| Tgene | MPHOSPH8 | chr14:66975309 | chr13:20233135 | ENST00000414242 | 4 | 13 | 633_662 | 525 | 868.0 | Repeat | Note=ANK 2 | |
| Tgene | MPHOSPH8 | chr14:66975309 | chr13:20233135 | ENST00000414242 | 4 | 13 | 666_695 | 525 | 868.0 | Repeat | Note=ANK 3 | |
| Tgene | MPHOSPH8 | chr14:66975309 | chr13:20233135 | ENST00000414242 | 4 | 13 | 699_728 | 525 | 868.0 | Repeat | Note=ANK 4 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GPHN | chr14:66975309 | chr13:20233135 | ENST00000315266 | + | 1 | 22 | 14_166 | 21 | 737.0 | Region | Note=MPT Mo-transferase |
| Hgene | GPHN | chr14:66975309 | chr13:20233135 | ENST00000315266 | + | 1 | 22 | 326_736 | 21 | 737.0 | Region | Note=MPT adenylyltransferase |
| Hgene | GPHN | chr14:66975309 | chr13:20233135 | ENST00000478722 | + | 1 | 23 | 14_166 | 21 | 770.0 | Region | Note=MPT Mo-transferase |
| Hgene | GPHN | chr14:66975309 | chr13:20233135 | ENST00000478722 | + | 1 | 23 | 326_736 | 21 | 770.0 | Region | Note=MPT adenylyltransferase |
| Tgene | MPHOSPH8 | chr14:66975309 | chr13:20233135 | ENST00000361479 | 4 | 14 | 151_256 | 525 | 861.0 | Compositional bias | Note=Lys-rich | |
| Tgene | MPHOSPH8 | chr14:66975309 | chr13:20233135 | ENST00000414242 | 4 | 13 | 151_256 | 525 | 868.0 | Compositional bias | Note=Lys-rich | |
| Tgene | MPHOSPH8 | chr14:66975309 | chr13:20233135 | ENST00000361479 | 4 | 14 | 59_118 | 525 | 861.0 | Domain | Chromo | |
| Tgene | MPHOSPH8 | chr14:66975309 | chr13:20233135 | ENST00000414242 | 4 | 13 | 59_118 | 525 | 868.0 | Domain | Chromo | |
| Tgene | MPHOSPH8 | chr14:66975309 | chr13:20233135 | ENST00000361479 | 4 | 14 | 80_87 | 525 | 861.0 | Region | Histone H3K9me3 binding | |
| Tgene | MPHOSPH8 | chr14:66975309 | chr13:20233135 | ENST00000414242 | 4 | 13 | 80_87 | 525 | 868.0 | Region | Histone H3K9me3 binding |
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Fusion Gene Sequence for GPHN-MPHOSPH8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >34257_34257_1_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000305960_MPHOSPH8_chr13_20233135_ENST00000361479_length(transcript)=2670nt_BP=79nt ACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTGTCGGAGTCCTTACAGATGGCAGGCAG CAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGCACCTTGATGGGAAAGATGAGAATTTT GCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTACTGTAAAAGTTGCACTTAATTCAAAT GAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCGGAGGGCAGGACGACCTCCTGCGACTC CTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATGCTGCAGAGAAGAACTTTTTAACAACA GTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCACTGATGAAGGCCTGTAAAAGAGGAAAT TCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGAATAGTGCCCTGCACTTTGCGAAGCAG TCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAGAAGAGACAATAAAGGATTACTTTGAA GCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAGATTTTTCAACAGATTTCAATTACAAA CCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGGGTAAAGAAGTTATTGCTCGGCTCTGT GGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGGACAGTCATTTTGTTTACTCATTCAGCCCT GTTGCAGGTCCCAATAAACTCTTCATAAGGTTGACAGAAGCACCCTCTGCCAAGGTTAAGTTGCTAATAGGTGCATACAGAGTGCAGCTG CAGTGACCAAACAGAAGGGACTGGGCGGAGTTCTCTTCAGACCGATTCCTATACTCTCTTTGACAGCAGTTTGGAATTCTTCTAGCACAT CTATGTAAAGTTTTGTCTGTAAACCTCTTGCAGTTAAGCCTGTTGTCTGTTGTAGTCTGTAAGATGCGACATAGCTGTGTCTGTGCCAGT ATGCCGGAATCTCAGTGCAGTGTCCAGACTGCGTATTTCAGTTTTTCCACAATGTGGATAGTACATATGAGGATTATTTAAGAAAATTAA AGACTTCACTTTCTTTTTTCTGGAGACGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGCGATCTCGGCTCACTGCAAGCTC TGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGACACCCGCCATGGCACCCAGCTAATTTTGTAT TTTTAGTAGAGATGGGGTTTATCCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCGCCCGCCTCGGCCTCCCAAAGTG CTTGGATTACAGGCATGAGCCACCGCACCCAGCAAGAGTTATTTTCTTAACTTGAAATTTTCTACTAGCCCTGGTGAACTTCTGTGCTTA AAAAAAAAAAAAAAAAAAGGAAAAATTCAGCTCTAAAACATTTGCTTACAGCAAGGGAGCCATGTTATATTCAAGTTACCCAAGCACCAA ATAAAGTGTGGGTTTGCTGCCCTTGAAAGGGTTGGGAGGCCTGATCTTTTTCTAGTAGACAGTTGCCACACATTCCCCAAGCACAAAAGG TGGAGATGGCAGTCACTTTGTAAATATGCTGTAGTCACTTATCATCTTTTCAAAGGGTAACAAGAGAATCTAAGATGTAGTAAGAATGTA AACCAGTACACTATGAGACCTAAAAGAGAGTATTAAATGTGAACTTTTAGCAGAGCGTGGTGGCTCACACCTATAATCCCAGCGCTTTGG AGGCTGAGGTTGGAGGATTGCTTAAGTCCAGGAGTTCAAGACCAGCCTGGGTAACATGGGGTGGAACAAGCCTGTAGTCCCAGATACTCA GGAGGCTGAGGTGAAAGGATTGCTTGAGCCAGGGAGGTCAAGGCTGCAGTGAGCCGTGAAAGGCCACTGCACTCCAGCCTGAGTGACAGA ATGAGACCTTGTCTCAAAAAAAAAAAAAAGTTTCTTGGAACCTATACGGTTTTTTTTTGTTTTTTTTTTTTGAAAAGCCAGACCTTGTGC CCTTGTTTTGAACACCGACTGGGAAGATGGGGCTTAGGTAACAGCCAAACCTGGCTGTCAGCTGTGTGGGAGCCACCACCCTCTCTGGGA AGAGTTCCTGCTTCTGTATGGCAAGCATAAATCAAGCTCAGTCTGGGTTATGGAGAAGTTGAAAATTGTTTTGTTCCTCATTAGTTTATA ATTGTATGAAATACGATTTTAATGAAAACTTTTCAGAATTCACGTTTGTGTAGATATTTCAGAGAACCATTTTTACTTTACATCCTAAAA CTGCCTTTTCCTATGGTTTTGTCAATAAAACACTATGATGTTGGTCTGTTTCCTTTTATA >34257_34257_1_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000305960_MPHOSPH8_chr13_20233135_ENST00000361479_length(amino acids)=359AA_BP=24 MGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEE YNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSD IVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSTDFNYKPP QNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAGPNKLFIRLTEAPSAKVKLLIGAYRVQLQ -------------------------------------------------------------- >34257_34257_2_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000305960_MPHOSPH8_chr13_20233135_ENST00000414242_length(transcript)=1107nt_BP=79nt ACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTGTCGGAGTCCTTACAGATGGCAGGCAG CAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGCACCTTGATGGGAAAGATGAGAATTTT GCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTACTGTAAAAGTTGCACTTAATTCAAAT GAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCGGAGGGCAGGACGACCTCCTGCGACTC CTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATGCTGCAGAGAAGAACTTTTTAACAACA GTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCACTGATGAAGGCCTGTAAAAGAGGAAAT TCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGAATAGTGCCCTGCACTTTGCGAAGCAG TCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAGAAGAGACAATAAAGGATTACTTTGAA GCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAGATTTTTCAACAGATTTCAATTACAAA CCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGGGTAAAGAAGTTATTGCTCGGCTCTGT GGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGACAGGGTCTCGCTCTGTTGTCCAGGCTGGA GTGCAGTGGCGCGGATTACAGCTCACTGGAGTCTTGACTTCCCAGGCACAAGCAATCCTCCCACCTCAGCCTCCTAACTACCTGGGACTA AAAATGCACGCCACCACATCCGGCTAA >34257_34257_2_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000305960_MPHOSPH8_chr13_20233135_ENST00000414242_length(amino acids)=366AA_BP=323 MGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEE YNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSD IVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSTDFNYKPP QNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLTGSRSVVQAGVQWRGLQLTGVLTSQAQAILPPQPPNYLGLKM HATTSG -------------------------------------------------------------- >34257_34257_3_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000315266_MPHOSPH8_chr13_20233135_ENST00000361479_length(transcript)=3776nt_BP=1185nt AGCAGCGCTCATGGCGAAGAGGCTTAAGGCCACAAAACCGTGGGACAGCAGGAGGAAGAGAAGCCAGGTATCTCCACTCCAGCTGCCCTG CCTCAGACTCCTCAGTTTCGCACGTGAGGATCGTCTTGCAGGCACTGACTGGAGATGGAATCCTAAAGCATAGGTGAAGCGGAAATCCTC CTTCAGGGAGAGCCCACTGAGGAAGCCAGCGGCTAGCACGAGGCAGGACAGGATACCTCCCTCTTCGCCCACGGCGGCCTCTCTGTCATA GTAGCCACCGTTCTGCCACTCATGCAGCTTTCTAAGACACCTCTCGGTTCCCCAGCGCTTTCAGTGGGGCGGCCGGCCATTCCCGAGGGT TGCAAGAGGAGGCCCGGGGTGCTGAGCCAGCCTCGCTGCCCCCGCGTAGAAAGCCGGCCCGCCGGCGAGAGCCAGCCTAAGGCGCGGACA ACCAACGAGGTGTCAGGCTCGGCAGGGGATTGCTTCTGTCTGGGGCCCGGCCGAGGTTGCGTTCGTGCCTCGCGCGCACACGCTCCGCGT TCACTCAGCCAATCCGGTGCTACTCGCGCGCCCAGGAGCGATCCGCGGTCCTACTCAGGCTGGGCCGGCTCCTTCCCGCTCCCAATACTC AGCACCCGAGCTCTCACTCCTCCCCTCACTCTCCACGAGTTCCACGCCTAGGGGTGTAGCTCCGCCCTTGTCCCCGAGTCCGCCCCCGCA ACCTCCAGAGCGTGTGCTATCCTTTCCTCTCAGTCCTGCCATCTAGCTGCCTTGGGTCTCGCGCTCCGCAGAGCGTTCCGACACTCTCCG GCCTCGTTCTGCCGCCTCCGCGCGCTCTCCCCGTGCGGCCACCGCGCCCCCCAAGCTTGCCTCCTTCTTGCCGGACTTGGGGCCGCGCGC CCTGACTCCTTCCCCTCCCGCGGACCCGCGCACTCCCGGCGCGGCCTCTCCCCCACGCAGGCCACCGTGCACTCTGTGGCCTCCCCCTCC TTCCCCGCTCTCCTCGCGCTTCTCTGGCTCCCTAGCTGTCGCGCTCTCCTCGGCGAGCGCGCTCCCGGCCCGCGCGCTCCGGGCTCCGGT TTCTCCCGGCTCCTGTCAGTGCGGTGACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTG TCGGAGTCCTTACAGATGGCAGGCAGCAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGC ACCTTGATGGGAAAGATGAGAATTTTGCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTA CTGTAAAAGTTGCACTTAATTCAAATGAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCG GAGGGCAGGACGACCTCCTGCGACTCCTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATG CTGCAGAGAAGAACTTTTTAACAACAGTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCAC TGATGAAGGCCTGTAAAAGAGGAAATTCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGA ATAGTGCCCTGCACTTTGCGAAGCAGTCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAG AAGAGACAATAAAGGATTACTTTGAAGCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAG ATTTTTCAACAGATTTCAATTACAAACCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGG GTAAAGAAGTTATTGCTCGGCTCTGTGGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGGACA GTCATTTTGTTTACTCATTCAGCCCTGTTGCAGGTCCCAATAAACTCTTCATAAGGTTGACAGAAGCACCCTCTGCCAAGGTTAAGTTGC TAATAGGTGCATACAGAGTGCAGCTGCAGTGACCAAACAGAAGGGACTGGGCGGAGTTCTCTTCAGACCGATTCCTATACTCTCTTTGAC AGCAGTTTGGAATTCTTCTAGCACATCTATGTAAAGTTTTGTCTGTAAACCTCTTGCAGTTAAGCCTGTTGTCTGTTGTAGTCTGTAAGA TGCGACATAGCTGTGTCTGTGCCAGTATGCCGGAATCTCAGTGCAGTGTCCAGACTGCGTATTTCAGTTTTTCCACAATGTGGATAGTAC ATATGAGGATTATTTAAGAAAATTAAAGACTTCACTTTCTTTTTTCTGGAGACGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATG GTGCGATCTCGGCTCACTGCAAGCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGACACCC GCCATGGCACCCAGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTATCCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGA TCCGCCCGCCTCGGCCTCCCAAAGTGCTTGGATTACAGGCATGAGCCACCGCACCCAGCAAGAGTTATTTTCTTAACTTGAAATTTTCTA CTAGCCCTGGTGAACTTCTGTGCTTAAAAAAAAAAAAAAAAAAAGGAAAAATTCAGCTCTAAAACATTTGCTTACAGCAAGGGAGCCATG TTATATTCAAGTTACCCAAGCACCAAATAAAGTGTGGGTTTGCTGCCCTTGAAAGGGTTGGGAGGCCTGATCTTTTTCTAGTAGACAGTT GCCACACATTCCCCAAGCACAAAAGGTGGAGATGGCAGTCACTTTGTAAATATGCTGTAGTCACTTATCATCTTTTCAAAGGGTAACAAG AGAATCTAAGATGTAGTAAGAATGTAAACCAGTACACTATGAGACCTAAAAGAGAGTATTAAATGTGAACTTTTAGCAGAGCGTGGTGGC TCACACCTATAATCCCAGCGCTTTGGAGGCTGAGGTTGGAGGATTGCTTAAGTCCAGGAGTTCAAGACCAGCCTGGGTAACATGGGGTGG AACAAGCCTGTAGTCCCAGATACTCAGGAGGCTGAGGTGAAAGGATTGCTTGAGCCAGGGAGGTCAAGGCTGCAGTGAGCCGTGAAAGGC CACTGCACTCCAGCCTGAGTGACAGAATGAGACCTTGTCTCAAAAAAAAAAAAAAGTTTCTTGGAACCTATACGGTTTTTTTTTGTTTTT TTTTTTTGAAAAGCCAGACCTTGTGCCCTTGTTTTGAACACCGACTGGGAAGATGGGGCTTAGGTAACAGCCAAACCTGGCTGTCAGCTG TGTGGGAGCCACCACCCTCTCTGGGAAGAGTTCCTGCTTCTGTATGGCAAGCATAAATCAAGCTCAGTCTGGGTTATGGAGAAGTTGAAA ATTGTTTTGTTCCTCATTAGTTTATAATTGTATGAAATACGATTTTAATGAAAACTTTTCAGAATTCACGTTTGTGTAGATATTTCAGAG AACCATTTTTACTTTACATCCTAAAACTGCCTTTTCCTATGGTTTTGTCAATAAAACACTATGATGTTGGTCTGTTTCCTTTTATA >34257_34257_3_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000315266_MPHOSPH8_chr13_20233135_ENST00000361479_length(amino acids)=388AA_BP=53 MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAAT DAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAI LLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARL ALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAG PNKLFIRLTEAPSAKVKLLIGAYRVQLQ -------------------------------------------------------------- >34257_34257_4_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000315266_MPHOSPH8_chr13_20233135_ENST00000414242_length(transcript)=2213nt_BP=1185nt AGCAGCGCTCATGGCGAAGAGGCTTAAGGCCACAAAACCGTGGGACAGCAGGAGGAAGAGAAGCCAGGTATCTCCACTCCAGCTGCCCTG CCTCAGACTCCTCAGTTTCGCACGTGAGGATCGTCTTGCAGGCACTGACTGGAGATGGAATCCTAAAGCATAGGTGAAGCGGAAATCCTC CTTCAGGGAGAGCCCACTGAGGAAGCCAGCGGCTAGCACGAGGCAGGACAGGATACCTCCCTCTTCGCCCACGGCGGCCTCTCTGTCATA GTAGCCACCGTTCTGCCACTCATGCAGCTTTCTAAGACACCTCTCGGTTCCCCAGCGCTTTCAGTGGGGCGGCCGGCCATTCCCGAGGGT TGCAAGAGGAGGCCCGGGGTGCTGAGCCAGCCTCGCTGCCCCCGCGTAGAAAGCCGGCCCGCCGGCGAGAGCCAGCCTAAGGCGCGGACA ACCAACGAGGTGTCAGGCTCGGCAGGGGATTGCTTCTGTCTGGGGCCCGGCCGAGGTTGCGTTCGTGCCTCGCGCGCACACGCTCCGCGT TCACTCAGCCAATCCGGTGCTACTCGCGCGCCCAGGAGCGATCCGCGGTCCTACTCAGGCTGGGCCGGCTCCTTCCCGCTCCCAATACTC AGCACCCGAGCTCTCACTCCTCCCCTCACTCTCCACGAGTTCCACGCCTAGGGGTGTAGCTCCGCCCTTGTCCCCGAGTCCGCCCCCGCA ACCTCCAGAGCGTGTGCTATCCTTTCCTCTCAGTCCTGCCATCTAGCTGCCTTGGGTCTCGCGCTCCGCAGAGCGTTCCGACACTCTCCG GCCTCGTTCTGCCGCCTCCGCGCGCTCTCCCCGTGCGGCCACCGCGCCCCCCAAGCTTGCCTCCTTCTTGCCGGACTTGGGGCCGCGCGC CCTGACTCCTTCCCCTCCCGCGGACCCGCGCACTCCCGGCGCGGCCTCTCCCCCACGCAGGCCACCGTGCACTCTGTGGCCTCCCCCTCC TTCCCCGCTCTCCTCGCGCTTCTCTGGCTCCCTAGCTGTCGCGCTCTCCTCGGCGAGCGCGCTCCCGGCCCGCGCGCTCCGGGCTCCGGT TTCTCCCGGCTCCTGTCAGTGCGGTGACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTG TCGGAGTCCTTACAGATGGCAGGCAGCAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGC ACCTTGATGGGAAAGATGAGAATTTTGCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTA CTGTAAAAGTTGCACTTAATTCAAATGAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCG GAGGGCAGGACGACCTCCTGCGACTCCTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATG CTGCAGAGAAGAACTTTTTAACAACAGTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCAC TGATGAAGGCCTGTAAAAGAGGAAATTCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGA ATAGTGCCCTGCACTTTGCGAAGCAGTCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAG AAGAGACAATAAAGGATTACTTTGAAGCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAG ATTTTTCAACAGATTTCAATTACAAACCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGG GTAAAGAAGTTATTGCTCGGCTCTGTGGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGACAG GGTCTCGCTCTGTTGTCCAGGCTGGAGTGCAGTGGCGCGGATTACAGCTCACTGGAGTCTTGACTTCCCAGGCACAAGCAATCCTCCCAC CTCAGCCTCCTAACTACCTGGGACTAAAAATGCACGCCACCACATCCGGCTAA >34257_34257_4_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000315266_MPHOSPH8_chr13_20233135_ENST00000414242_length(amino acids)=396AA_BP=352 MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAAT DAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAI LLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARL ALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLTGSRSVVQAGVQW RGLQLTGVLTSQAQAILPPQPPNYLGLKMHATTSGX -------------------------------------------------------------- >34257_34257_5_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000459628_MPHOSPH8_chr13_20233135_ENST00000361479_length(transcript)=3045nt_BP=454nt GTGTGCTATCCTTTCCTCTCAGTCCTGCCATCTAGCTGCCTTGGGTCTCGCGCTCCGCAGAGCGTTCCGACACTCTCCGGCCTCGTTCTG CCGCCTCCGCGCGCTCTCCCCGTGCGGCCACCGCGCCCCCCAAGCTTGCCTCCTTCTTGCCGGACTTGGGGCCGCGCGCCCTGACTCCTT CCCCTCCCGCGGACCCGCGCACTCCCGGCGCGGCCTCTCCCCCACGCAGGCCACCGTGCACTCTGTGGCCTCCCCCTCCTTCCCCGCTCT CCTCGCGCTTCTCTGGCTCCCTAGCTGTCGCGCTCTCCTCGGCGAGCGCGCTCCCGGCCCGCGCGCTCCGGGCTCCGGTTTCTCCCGGCT CCTGTCAGTGCGGTGACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTGTCGGAGTCCTT ACAGATGGCAGGCAGCAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGCACCTTGATGGG AAAGATGAGAATTTTGCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTACTGTAAAAGTT GCACTTAATTCAAATGAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCGGAGGGCAGGAC GACCTCCTGCGACTCCTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATGCTGCAGAGAAG AACTTTTTAACAACAGTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCACTGATGAAGGCC TGTAAAAGAGGAAATTCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGAATAGTGCCCTG CACTTTGCGAAGCAGTCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAGAAGAGACAATA AAGGATTACTTTGAAGCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAGATTTTTCAACA GATTTCAATTACAAACCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGGGTAAAGAAGTT ATTGCTCGGCTCTGTGGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGGACAGTCATTTTGTT TACTCATTCAGCCCTGTTGCAGGTCCCAATAAACTCTTCATAAGGTTGACAGAAGCACCCTCTGCCAAGGTTAAGTTGCTAATAGGTGCA TACAGAGTGCAGCTGCAGTGACCAAACAGAAGGGACTGGGCGGAGTTCTCTTCAGACCGATTCCTATACTCTCTTTGACAGCAGTTTGGA ATTCTTCTAGCACATCTATGTAAAGTTTTGTCTGTAAACCTCTTGCAGTTAAGCCTGTTGTCTGTTGTAGTCTGTAAGATGCGACATAGC TGTGTCTGTGCCAGTATGCCGGAATCTCAGTGCAGTGTCCAGACTGCGTATTTCAGTTTTTCCACAATGTGGATAGTACATATGAGGATT ATTTAAGAAAATTAAAGACTTCACTTTCTTTTTTCTGGAGACGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGCGATCTCG GCTCACTGCAAGCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGACACCCGCCATGGCACC CAGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTATCCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCGCCCGCCT CGGCCTCCCAAAGTGCTTGGATTACAGGCATGAGCCACCGCACCCAGCAAGAGTTATTTTCTTAACTTGAAATTTTCTACTAGCCCTGGT GAACTTCTGTGCTTAAAAAAAAAAAAAAAAAAAGGAAAAATTCAGCTCTAAAACATTTGCTTACAGCAAGGGAGCCATGTTATATTCAAG TTACCCAAGCACCAAATAAAGTGTGGGTTTGCTGCCCTTGAAAGGGTTGGGAGGCCTGATCTTTTTCTAGTAGACAGTTGCCACACATTC CCCAAGCACAAAAGGTGGAGATGGCAGTCACTTTGTAAATATGCTGTAGTCACTTATCATCTTTTCAAAGGGTAACAAGAGAATCTAAGA TGTAGTAAGAATGTAAACCAGTACACTATGAGACCTAAAAGAGAGTATTAAATGTGAACTTTTAGCAGAGCGTGGTGGCTCACACCTATA ATCCCAGCGCTTTGGAGGCTGAGGTTGGAGGATTGCTTAAGTCCAGGAGTTCAAGACCAGCCTGGGTAACATGGGGTGGAACAAGCCTGT AGTCCCAGATACTCAGGAGGCTGAGGTGAAAGGATTGCTTGAGCCAGGGAGGTCAAGGCTGCAGTGAGCCGTGAAAGGCCACTGCACTCC AGCCTGAGTGACAGAATGAGACCTTGTCTCAAAAAAAAAAAAAAGTTTCTTGGAACCTATACGGTTTTTTTTTGTTTTTTTTTTTTGAAA AGCCAGACCTTGTGCCCTTGTTTTGAACACCGACTGGGAAGATGGGGCTTAGGTAACAGCCAAACCTGGCTGTCAGCTGTGTGGGAGCCA CCACCCTCTCTGGGAAGAGTTCCTGCTTCTGTATGGCAAGCATAAATCAAGCTCAGTCTGGGTTATGGAGAAGTTGAAAATTGTTTTGTT CCTCATTAGTTTATAATTGTATGAAATACGATTTTAATGAAAACTTTTCAGAATTCACGTTTGTGTAGATATTTCAGAGAACCATTTTTA CTTTACATCCTAAAACTGCCTTTTCCTATGGTTTTGTCAATAAAACACTATGATGTTGGTCTGTTTCCTTTTATA >34257_34257_5_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000459628_MPHOSPH8_chr13_20233135_ENST00000361479_length(amino acids)=388AA_BP=53 MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAAT DAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAI LLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARL ALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAG PNKLFIRLTEAPSAKVKLLIGAYRVQLQ -------------------------------------------------------------- >34257_34257_6_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000459628_MPHOSPH8_chr13_20233135_ENST00000414242_length(transcript)=1482nt_BP=454nt GTGTGCTATCCTTTCCTCTCAGTCCTGCCATCTAGCTGCCTTGGGTCTCGCGCTCCGCAGAGCGTTCCGACACTCTCCGGCCTCGTTCTG CCGCCTCCGCGCGCTCTCCCCGTGCGGCCACCGCGCCCCCCAAGCTTGCCTCCTTCTTGCCGGACTTGGGGCCGCGCGCCCTGACTCCTT CCCCTCCCGCGGACCCGCGCACTCCCGGCGCGGCCTCTCCCCCACGCAGGCCACCGTGCACTCTGTGGCCTCCCCCTCCTTCCCCGCTCT CCTCGCGCTTCTCTGGCTCCCTAGCTGTCGCGCTCTCCTCGGCGAGCGCGCTCCCGGCCCGCGCGCTCCGGGCTCCGGTTTCTCCCGGCT CCTGTCAGTGCGGTGACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTGTCGGAGTCCTT ACAGATGGCAGGCAGCAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGCACCTTGATGGG AAAGATGAGAATTTTGCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTACTGTAAAAGTT GCACTTAATTCAAATGAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCGGAGGGCAGGAC GACCTCCTGCGACTCCTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATGCTGCAGAGAAG AACTTTTTAACAACAGTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCACTGATGAAGGCC TGTAAAAGAGGAAATTCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGAATAGTGCCCTG CACTTTGCGAAGCAGTCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAGAAGAGACAATA AAGGATTACTTTGAAGCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAGATTTTTCAACA GATTTCAATTACAAACCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGGGTAAAGAAGTT ATTGCTCGGCTCTGTGGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGACAGGGTCTCGCTCT GTTGTCCAGGCTGGAGTGCAGTGGCGCGGATTACAGCTCACTGGAGTCTTGACTTCCCAGGCACAAGCAATCCTCCCACCTCAGCCTCCT AACTACCTGGGACTAAAAATGCACGCCACCACATCCGGCTAA >34257_34257_6_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000459628_MPHOSPH8_chr13_20233135_ENST00000414242_length(amino acids)=395AA_BP=352 MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAAT DAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAI LLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARL ALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLTGSRSVVQAGVQW RGLQLTGVLTSQAQAILPPQPPNYLGLKMHATTSG -------------------------------------------------------------- >34257_34257_7_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000478722_MPHOSPH8_chr13_20233135_ENST00000361479_length(transcript)=3776nt_BP=1185nt AGCAGCGCTCATGGCGAAGAGGCTTAAGGCCACAAAACCGTGGGACAGCAGGAGGAAGAGAAGCCAGGTATCTCCACTCCAGCTGCCCTG CCTCAGACTCCTCAGTTTCGCACGTGAGGATCGTCTTGCAGGCACTGACTGGAGATGGAATCCTAAAGCATAGGTGAAGCGGAAATCCTC CTTCAGGGAGAGCCCACTGAGGAAGCCAGCGGCTAGCACGAGGCAGGACAGGATACCTCCCTCTTCGCCCACGGCGGCCTCTCTGTCATA GTAGCCACCGTTCTGCCACTCATGCAGCTTTCTAAGACACCTCTCGGTTCCCCAGCGCTTTCAGTGGGGCGGCCGGCCATTCCCGAGGGT TGCAAGAGGAGGCCCGGGGTGCTGAGCCAGCCTCGCTGCCCCCGCGTAGAAAGCCGGCCCGCCGGCGAGAGCCAGCCTAAGGCGCGGACA ACCAACGAGGTGTCAGGCTCGGCAGGGGATTGCTTCTGTCTGGGGCCCGGCCGAGGTTGCGTTCGTGCCTCGCGCGCACACGCTCCGCGT TCACTCAGCCAATCCGGTGCTACTCGCGCGCCCAGGAGCGATCCGCGGTCCTACTCAGGCTGGGCCGGCTCCTTCCCGCTCCCAATACTC AGCACCCGAGCTCTCACTCCTCCCCTCACTCTCCACGAGTTCCACGCCTAGGGGTGTAGCTCCGCCCTTGTCCCCGAGTCCGCCCCCGCA ACCTCCAGAGCGTGTGCTATCCTTTCCTCTCAGTCCTGCCATCTAGCTGCCTTGGGTCTCGCGCTCCGCAGAGCGTTCCGACACTCTCCG GCCTCGTTCTGCCGCCTCCGCGCGCTCTCCCCGTGCGGCCACCGCGCCCCCCAAGCTTGCCTCCTTCTTGCCGGACTTGGGGCCGCGCGC CCTGACTCCTTCCCCTCCCGCGGACCCGCGCACTCCCGGCGCGGCCTCTCCCCCACGCAGGCCACCGTGCACTCTGTGGCCTCCCCCTCC TTCCCCGCTCTCCTCGCGCTTCTCTGGCTCCCTAGCTGTCGCGCTCTCCTCGGCGAGCGCGCTCCCGGCCCGCGCGCTCCGGGCTCCGGT TTCTCCCGGCTCCTGTCAGTGCGGTGACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTG TCGGAGTCCTTACAGATGGCAGGCAGCAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGC ACCTTGATGGGAAAGATGAGAATTTTGCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTA CTGTAAAAGTTGCACTTAATTCAAATGAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCG GAGGGCAGGACGACCTCCTGCGACTCCTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATG CTGCAGAGAAGAACTTTTTAACAACAGTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCAC TGATGAAGGCCTGTAAAAGAGGAAATTCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGA ATAGTGCCCTGCACTTTGCGAAGCAGTCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAG AAGAGACAATAAAGGATTACTTTGAAGCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAG ATTTTTCAACAGATTTCAATTACAAACCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGG GTAAAGAAGTTATTGCTCGGCTCTGTGGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGGACA GTCATTTTGTTTACTCATTCAGCCCTGTTGCAGGTCCCAATAAACTCTTCATAAGGTTGACAGAAGCACCCTCTGCCAAGGTTAAGTTGC TAATAGGTGCATACAGAGTGCAGCTGCAGTGACCAAACAGAAGGGACTGGGCGGAGTTCTCTTCAGACCGATTCCTATACTCTCTTTGAC AGCAGTTTGGAATTCTTCTAGCACATCTATGTAAAGTTTTGTCTGTAAACCTCTTGCAGTTAAGCCTGTTGTCTGTTGTAGTCTGTAAGA TGCGACATAGCTGTGTCTGTGCCAGTATGCCGGAATCTCAGTGCAGTGTCCAGACTGCGTATTTCAGTTTTTCCACAATGTGGATAGTAC ATATGAGGATTATTTAAGAAAATTAAAGACTTCACTTTCTTTTTTCTGGAGACGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATG GTGCGATCTCGGCTCACTGCAAGCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGACACCC GCCATGGCACCCAGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTATCCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGA TCCGCCCGCCTCGGCCTCCCAAAGTGCTTGGATTACAGGCATGAGCCACCGCACCCAGCAAGAGTTATTTTCTTAACTTGAAATTTTCTA CTAGCCCTGGTGAACTTCTGTGCTTAAAAAAAAAAAAAAAAAAAGGAAAAATTCAGCTCTAAAACATTTGCTTACAGCAAGGGAGCCATG TTATATTCAAGTTACCCAAGCACCAAATAAAGTGTGGGTTTGCTGCCCTTGAAAGGGTTGGGAGGCCTGATCTTTTTCTAGTAGACAGTT GCCACACATTCCCCAAGCACAAAAGGTGGAGATGGCAGTCACTTTGTAAATATGCTGTAGTCACTTATCATCTTTTCAAAGGGTAACAAG AGAATCTAAGATGTAGTAAGAATGTAAACCAGTACACTATGAGACCTAAAAGAGAGTATTAAATGTGAACTTTTAGCAGAGCGTGGTGGC TCACACCTATAATCCCAGCGCTTTGGAGGCTGAGGTTGGAGGATTGCTTAAGTCCAGGAGTTCAAGACCAGCCTGGGTAACATGGGGTGG AACAAGCCTGTAGTCCCAGATACTCAGGAGGCTGAGGTGAAAGGATTGCTTGAGCCAGGGAGGTCAAGGCTGCAGTGAGCCGTGAAAGGC CACTGCACTCCAGCCTGAGTGACAGAATGAGACCTTGTCTCAAAAAAAAAAAAAAGTTTCTTGGAACCTATACGGTTTTTTTTTGTTTTT TTTTTTTGAAAAGCCAGACCTTGTGCCCTTGTTTTGAACACCGACTGGGAAGATGGGGCTTAGGTAACAGCCAAACCTGGCTGTCAGCTG TGTGGGAGCCACCACCCTCTCTGGGAAGAGTTCCTGCTTCTGTATGGCAAGCATAAATCAAGCTCAGTCTGGGTTATGGAGAAGTTGAAA ATTGTTTTGTTCCTCATTAGTTTATAATTGTATGAAATACGATTTTAATGAAAACTTTTCAGAATTCACGTTTGTGTAGATATTTCAGAG AACCATTTTTACTTTACATCCTAAAACTGCCTTTTCCTATGGTTTTGTCAATAAAACACTATGATGTTGGTCTGTTTCCTTTTATA >34257_34257_7_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000478722_MPHOSPH8_chr13_20233135_ENST00000361479_length(amino acids)=388AA_BP=53 MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAAT DAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAI LLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARL ALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAG PNKLFIRLTEAPSAKVKLLIGAYRVQLQ -------------------------------------------------------------- >34257_34257_8_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000478722_MPHOSPH8_chr13_20233135_ENST00000414242_length(transcript)=2213nt_BP=1185nt AGCAGCGCTCATGGCGAAGAGGCTTAAGGCCACAAAACCGTGGGACAGCAGGAGGAAGAGAAGCCAGGTATCTCCACTCCAGCTGCCCTG CCTCAGACTCCTCAGTTTCGCACGTGAGGATCGTCTTGCAGGCACTGACTGGAGATGGAATCCTAAAGCATAGGTGAAGCGGAAATCCTC CTTCAGGGAGAGCCCACTGAGGAAGCCAGCGGCTAGCACGAGGCAGGACAGGATACCTCCCTCTTCGCCCACGGCGGCCTCTCTGTCATA GTAGCCACCGTTCTGCCACTCATGCAGCTTTCTAAGACACCTCTCGGTTCCCCAGCGCTTTCAGTGGGGCGGCCGGCCATTCCCGAGGGT TGCAAGAGGAGGCCCGGGGTGCTGAGCCAGCCTCGCTGCCCCCGCGTAGAAAGCCGGCCCGCCGGCGAGAGCCAGCCTAAGGCGCGGACA ACCAACGAGGTGTCAGGCTCGGCAGGGGATTGCTTCTGTCTGGGGCCCGGCCGAGGTTGCGTTCGTGCCTCGCGCGCACACGCTCCGCGT TCACTCAGCCAATCCGGTGCTACTCGCGCGCCCAGGAGCGATCCGCGGTCCTACTCAGGCTGGGCCGGCTCCTTCCCGCTCCCAATACTC AGCACCCGAGCTCTCACTCCTCCCCTCACTCTCCACGAGTTCCACGCCTAGGGGTGTAGCTCCGCCCTTGTCCCCGAGTCCGCCCCCGCA ACCTCCAGAGCGTGTGCTATCCTTTCCTCTCAGTCCTGCCATCTAGCTGCCTTGGGTCTCGCGCTCCGCAGAGCGTTCCGACACTCTCCG GCCTCGTTCTGCCGCCTCCGCGCGCTCTCCCCGTGCGGCCACCGCGCCCCCCAAGCTTGCCTCCTTCTTGCCGGACTTGGGGCCGCGCGC CCTGACTCCTTCCCCTCCCGCGGACCCGCGCACTCCCGGCGCGGCCTCTCCCCCACGCAGGCCACCGTGCACTCTGTGGCCTCCCCCTCC TTCCCCGCTCTCCTCGCGCTTCTCTGGCTCCCTAGCTGTCGCGCTCTCCTCGGCGAGCGCGCTCCCGGCCCGCGCGCTCCGGGCTCCGGT TTCTCCCGGCTCCTGTCAGTGCGGTGACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTG TCGGAGTCCTTACAGATGGCAGGCAGCAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGC ACCTTGATGGGAAAGATGAGAATTTTGCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTA CTGTAAAAGTTGCACTTAATTCAAATGAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCG GAGGGCAGGACGACCTCCTGCGACTCCTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATG CTGCAGAGAAGAACTTTTTAACAACAGTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCAC TGATGAAGGCCTGTAAAAGAGGAAATTCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGA ATAGTGCCCTGCACTTTGCGAAGCAGTCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAG AAGAGACAATAAAGGATTACTTTGAAGCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAG ATTTTTCAACAGATTTCAATTACAAACCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGG GTAAAGAAGTTATTGCTCGGCTCTGTGGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGACAG GGTCTCGCTCTGTTGTCCAGGCTGGAGTGCAGTGGCGCGGATTACAGCTCACTGGAGTCTTGACTTCCCAGGCACAAGCAATCCTCCCAC CTCAGCCTCCTAACTACCTGGGACTAAAAATGCACGCCACCACATCCGGCTAA >34257_34257_8_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000478722_MPHOSPH8_chr13_20233135_ENST00000414242_length(amino acids)=396AA_BP=352 MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAAT DAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAI LLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARL ALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLTGSRSVVQAGVQW RGLQLTGVLTSQAQAILPPQPPNYLGLKMHATTSGX -------------------------------------------------------------- >34257_34257_9_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000543237_MPHOSPH8_chr13_20233135_ENST00000361479_length(transcript)=2679nt_BP=88nt AGTGCGGTGACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTGTCGGAGTCCTTACAGAT GGCAGGCAGCAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGCACCTTGATGGGAAAGAT GAGAATTTTGCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTACTGTAAAAGTTGCACTT AATTCAAATGAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCGGAGGGCAGGACGACCTC CTGCGACTCCTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATGCTGCAGAGAAGAACTTT TTAACAACAGTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCACTGATGAAGGCCTGTAAA AGAGGAAATTCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGAATAGTGCCCTGCACTTT GCGAAGCAGTCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAGAAGAGACAATAAAGGAT TACTTTGAAGCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAGATTTTTCAACAGATTTC AATTACAAACCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGGGTAAAGAAGTTATTGCT CGGCTCTGTGGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGGACAGTCATTTTGTTTACTCA TTCAGCCCTGTTGCAGGTCCCAATAAACTCTTCATAAGGTTGACAGAAGCACCCTCTGCCAAGGTTAAGTTGCTAATAGGTGCATACAGA GTGCAGCTGCAGTGACCAAACAGAAGGGACTGGGCGGAGTTCTCTTCAGACCGATTCCTATACTCTCTTTGACAGCAGTTTGGAATTCTT CTAGCACATCTATGTAAAGTTTTGTCTGTAAACCTCTTGCAGTTAAGCCTGTTGTCTGTTGTAGTCTGTAAGATGCGACATAGCTGTGTC TGTGCCAGTATGCCGGAATCTCAGTGCAGTGTCCAGACTGCGTATTTCAGTTTTTCCACAATGTGGATAGTACATATGAGGATTATTTAA GAAAATTAAAGACTTCACTTTCTTTTTTCTGGAGACGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGCGATCTCGGCTCAC TGCAAGCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGACACCCGCCATGGCACCCAGCTA ATTTTGTATTTTTAGTAGAGATGGGGTTTATCCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCGCCCGCCTCGGCCT CCCAAAGTGCTTGGATTACAGGCATGAGCCACCGCACCCAGCAAGAGTTATTTTCTTAACTTGAAATTTTCTACTAGCCCTGGTGAACTT CTGTGCTTAAAAAAAAAAAAAAAAAAAGGAAAAATTCAGCTCTAAAACATTTGCTTACAGCAAGGGAGCCATGTTATATTCAAGTTACCC AAGCACCAAATAAAGTGTGGGTTTGCTGCCCTTGAAAGGGTTGGGAGGCCTGATCTTTTTCTAGTAGACAGTTGCCACACATTCCCCAAG CACAAAAGGTGGAGATGGCAGTCACTTTGTAAATATGCTGTAGTCACTTATCATCTTTTCAAAGGGTAACAAGAGAATCTAAGATGTAGT AAGAATGTAAACCAGTACACTATGAGACCTAAAAGAGAGTATTAAATGTGAACTTTTAGCAGAGCGTGGTGGCTCACACCTATAATCCCA GCGCTTTGGAGGCTGAGGTTGGAGGATTGCTTAAGTCCAGGAGTTCAAGACCAGCCTGGGTAACATGGGGTGGAACAAGCCTGTAGTCCC AGATACTCAGGAGGCTGAGGTGAAAGGATTGCTTGAGCCAGGGAGGTCAAGGCTGCAGTGAGCCGTGAAAGGCCACTGCACTCCAGCCTG AGTGACAGAATGAGACCTTGTCTCAAAAAAAAAAAAAAGTTTCTTGGAACCTATACGGTTTTTTTTTGTTTTTTTTTTTTGAAAAGCCAG ACCTTGTGCCCTTGTTTTGAACACCGACTGGGAAGATGGGGCTTAGGTAACAGCCAAACCTGGCTGTCAGCTGTGTGGGAGCCACCACCC TCTCTGGGAAGAGTTCCTGCTTCTGTATGGCAAGCATAAATCAAGCTCAGTCTGGGTTATGGAGAAGTTGAAAATTGTTTTGTTCCTCAT TAGTTTATAATTGTATGAAATACGATTTTAATGAAAACTTTTCAGAATTCACGTTTGTGTAGATATTTCAGAGAACCATTTTTACTTTAC ATCCTAAAACTGCCTTTTCCTATGGTTTTGTCAATAAAACACTATGATGTTGGTCTGTTTCCTTTTATA >34257_34257_9_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000543237_MPHOSPH8_chr13_20233135_ENST00000361479_length(amino acids)=359AA_BP=24 MGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEE YNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSD IVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSTDFNYKPP QNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAGPNKLFIRLTEAPSAKVKLLIGAYRVQLQ -------------------------------------------------------------- >34257_34257_10_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000543237_MPHOSPH8_chr13_20233135_ENST00000414242_length(transcript)=1116nt_BP=88nt AGTGCGGTGACTGCGCTGGGAAACATGGCGACCGAGGGAATGATCCTTACTAACCACGACCATCAAATCCGTGTCGGAGTCCTTACAGAT GGCAGGCAGCAGATTCTGAGTTTGGGCATGGACCTGCAGTTGGAATGGATGAAGTTGGAAGATTTCCAAAAGCACCTTGATGGGAAAGAT GAGAATTTTGCTGCAACAGATGCAATTCCAAGTAATGTGTTAAGGGATGCTGTGAAAAATGGGGATTATATTACTGTAAAAGTTGCACTT AATTCAAATGAAGAATATAACCTGGACCAAGAGGATTCCAGTGGAATGACACTGGTGATGCTTGCCGCCGCCGGAGGGCAGGACGACCTC CTGCGACTCCTCATCACAAAAGGCGCGAAAGTGAACGGTCGGCAGAAGAACGGGACCACCGCCCTCATTCATGCTGCAGAGAAGAACTTT TTAACAACAGTGGCTATTCTTTTGGAAGCAGGAGCTTTTGTAAATGTCCAGCAAAGCAATGGTGAGACTGCACTGATGAAGGCCTGTAAA AGAGGAAATTCAGACATCGTACGACTCGTAATTGAATGTGGAGCTGACTGCAATATTTTGTCAAAGCACCAGAATAGTGCCCTGCACTTT GCGAAGCAGTCTAACAATGTGCTTGTGTACGACTTGCTGAAGAACCATTTAGAGACACTTTCAAGAGTAGCAGAAGAGACAATAAAGGAT TACTTTGAAGCTCGCCTTGCTCTGCTAGAACCAGTTTTTCCAATCGCATGTCATCGACTCTGTGAGGGTCCAGATTTTTCAACAGATTTC AATTACAAACCCCCACAGAACATACCAGAAGGCTCTGGCATCCTGCTGTTTATCTTCCATGCAAACTTTTTGGGTAAAGAAGTTATTGCT CGGCTCTGTGGACCGTGTAGTGTACAAGCTGTAGTTCTGAATGATAAATTTCAGCTTCCTGTTTTTCTGACAGGGTCTCGCTCTGTTGTC CAGGCTGGAGTGCAGTGGCGCGGATTACAGCTCACTGGAGTCTTGACTTCCCAGGCACAAGCAATCCTCCCACCTCAGCCTCCTAACTAC CTGGGACTAAAAATGCACGCCACCACATCCGGCTAA >34257_34257_10_GPHN-MPHOSPH8_GPHN_chr14_66975309_ENST00000543237_MPHOSPH8_chr13_20233135_ENST00000414242_length(amino acids)=366AA_BP=323 MGNMATEGMILTNHDHQIRVGVLTDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEE YNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSD IVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSTDFNYKPP QNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLTGSRSVVQAGVQWRGLQLTGVLTSQAQAILPPQPPNYLGLKM HATTSG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for GPHN-MPHOSPH8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | GPHN | chr14:66975309 | chr13:20233135 | ENST00000315266 | + | 1 | 22 | 140_316 | 21.333333333333332 | 737.0 | GABARAP |
| Hgene | GPHN | chr14:66975309 | chr13:20233135 | ENST00000478722 | + | 1 | 23 | 140_316 | 21.333333333333332 | 770.0 | GABARAP |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for GPHN-MPHOSPH8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | GPHN | Q9NQX3 | DB03766 | Propanoic acid | Small molecule | Approved|Vet_approved | |
| Hgene | GPHN | Q9NQX3 | DB03766 | Propanoic acid | Small molecule | Approved|Vet_approved | |
| Hgene | GPHN | Q9NQX3 | DB03766 | Propanoic acid | Small molecule | Approved|Vet_approved |
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Related Diseases for GPHN-MPHOSPH8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GPHN | C1854990 | Molybdenum Cofactor Deficiency, Complementation Group C | 5 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Hgene | GPHN | C0001956 | Alcohol Use Disorder | 1 | CTD_human |
| Hgene | GPHN | C0001973 | Alcoholic Intoxication, Chronic | 1 | CTD_human |
| Hgene | GPHN | C0009171 | Cocaine Abuse | 1 | CTD_human |
| Hgene | GPHN | C0085762 | Alcohol abuse | 1 | CTD_human |
| Hgene | GPHN | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| Hgene | GPHN | C0543888 | Epileptic encephalopathy | 1 | GENOMICS_ENGLAND |
| Hgene | GPHN | C0600427 | Cocaine Dependence | 1 | CTD_human |
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