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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABCC4-UPF3A (FusionGDB2 ID:HG10257TG65110)

Fusion Gene Summary for ABCC4-UPF3A

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCC4-UPF3A
Fusion gene ID: hg10257tg65110
HgeneTgene
Gene symbol

ABCC4

UPF3A

Gene ID

10257

65110

Gene nameATP binding cassette subfamily C member 4UPF3A regulator of nonsense mediated mRNA decay
SynonymsMOAT-B|MOATB|MRP4HUPF3A|RENT3A|UPF3
Cytomap('ABCC4')('UPF3A')

13q32.1

13q34

Type of geneprotein-codingprotein-coding
Descriptionmultidrug resistance-associated protein 4MRP/cMOAT-related ABC transporterbA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)canalicular multispecific organic anion transporter (ABC superfamily)multi-specific organic anion transporter regulator of nonsense transcripts 3AUPF3 regulator of nonsense transcripts homolog AhUpf3nonsense mRNA reducing factor 3Aup-frameshift suppressor 3 homolog A
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000538287, ENST00000376887, 
ENST00000412704, ENST00000431522, 
ENST00000536256, ENST00000474158, 
Fusion gene scores* DoF score23 X 21 X 11=53137 X 7 X 5=245
# samples 257
** MAII scorelog2(25/5313*10)=-4.40952671281098
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABCC4 [Title/Abstract] AND UPF3A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABCC4(95899228)-UPF3A(115070263), # samples:1
Anticipated loss of major functional domain due to fusion event.ABCC4-UPF3A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC4-UPF3A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC4-UPF3A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC4-UPF3A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCC4

GO:0032310

prostaglandin secretion

25173977

TgeneUPF3A

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

16601204

TgeneUPF3A

GO:0045727

positive regulation of translation

16601204


check buttonFusion gene breakpoints across ABCC4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across UPF3A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-2020ABCC4chr13

95899228

-UPF3Achr13

115070263

+


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Fusion Gene ORF analysis for ABCC4-UPF3A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000538287ENST00000351487ABCC4chr13

95899228

-UPF3Achr13

115070263

+
3UTR-3CDSENST00000538287ENST00000375299ABCC4chr13

95899228

-UPF3Achr13

115070263

+
3UTR-3UTRENST00000538287ENST00000475218ABCC4chr13

95899228

-UPF3Achr13

115070263

+
5CDS-3UTRENST00000376887ENST00000475218ABCC4chr13

95899228

-UPF3Achr13

115070263

+
5CDS-3UTRENST00000412704ENST00000475218ABCC4chr13

95899228

-UPF3Achr13

115070263

+
5CDS-3UTRENST00000431522ENST00000475218ABCC4chr13

95899228

-UPF3Achr13

115070263

+
5CDS-3UTRENST00000536256ENST00000475218ABCC4chr13

95899228

-UPF3Achr13

115070263

+
In-frameENST00000376887ENST00000351487ABCC4chr13

95899228

-UPF3Achr13

115070263

+
In-frameENST00000376887ENST00000375299ABCC4chr13

95899228

-UPF3Achr13

115070263

+
In-frameENST00000412704ENST00000351487ABCC4chr13

95899228

-UPF3Achr13

115070263

+
In-frameENST00000412704ENST00000375299ABCC4chr13

95899228

-UPF3Achr13

115070263

+
In-frameENST00000431522ENST00000351487ABCC4chr13

95899228

-UPF3Achr13

115070263

+
In-frameENST00000431522ENST00000375299ABCC4chr13

95899228

-UPF3Achr13

115070263

+
In-frameENST00000536256ENST00000351487ABCC4chr13

95899228

-UPF3Achr13

115070263

+
In-frameENST00000536256ENST00000375299ABCC4chr13

95899228

-UPF3Achr13

115070263

+
intron-3CDSENST00000474158ENST00000351487ABCC4chr13

95899228

-UPF3Achr13

115070263

+
intron-3CDSENST00000474158ENST00000375299ABCC4chr13

95899228

-UPF3Achr13

115070263

+
intron-3UTRENST00000474158ENST00000475218ABCC4chr13

95899228

-UPF3Achr13

115070263

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000412704ABCC4chr1395899228-ENST00000375299UPF3Achr13115070263+1445425119553144
ENST00000412704ABCC4chr1395899228-ENST00000351487UPF3Achr13115070263+1445425119553144
ENST00000376887ABCC4chr1395899228-ENST00000375299UPF3Achr13115070263+1441421115549144
ENST00000376887ABCC4chr1395899228-ENST00000351487UPF3Achr13115070263+1441421115549144
ENST00000536256ABCC4chr1395899228-ENST00000375299UPF3Achr13115070263+1445425119553144
ENST00000536256ABCC4chr1395899228-ENST00000351487UPF3Achr13115070263+1445425119553144
ENST00000431522ABCC4chr1395899228-ENST00000375299UPF3Achr13115070263+1445425119553144
ENST00000431522ABCC4chr1395899228-ENST00000351487UPF3Achr13115070263+1445425119553144

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000412704ENST00000375299ABCC4chr1395899228-UPF3Achr13115070263+0.0170041490.9829958
ENST00000412704ENST00000351487ABCC4chr1395899228-UPF3Achr13115070263+0.0170041490.9829958
ENST00000376887ENST00000375299ABCC4chr1395899228-UPF3Achr13115070263+0.014533360.9854666
ENST00000376887ENST00000351487ABCC4chr1395899228-UPF3Achr13115070263+0.014533360.9854666
ENST00000536256ENST00000375299ABCC4chr1395899228-UPF3Achr13115070263+0.0170041490.9829958
ENST00000536256ENST00000351487ABCC4chr1395899228-UPF3Achr13115070263+0.0170041490.9829958
ENST00000431522ENST00000375299ABCC4chr1395899228-UPF3Achr13115070263+0.0170041490.9829958
ENST00000431522ENST00000351487ABCC4chr1395899228-UPF3Achr13115070263+0.0170041490.9829958

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Fusion Genomic Features for ABCC4-UPF3A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ABCC4chr1395899228-UPF3Achr13115070263+0.174786930.8252131
ABCC4chr1395899228-UPF3Achr13115070263+0.174786930.8252131

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ABCC4-UPF3A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:95899228/chr13:115070263)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUPF3Achr13:95899228chr13:115070263ENST0000035148779421_434401444.0RegionNote=Required for association with EIF4A3 and ECJ core components CASC3%2C MAGOH and RBM8A

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-3311041_12741021326.0DomainABC transporter 2
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-331410_6331021326.0DomainABC transporter 1
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-331714_10051021326.0DomainABC transmembrane type-1 2
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-33192_3771021326.0DomainABC transmembrane type-1 1
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-3301041_12741021279.0DomainABC transporter 2
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-330410_6331021279.0DomainABC transporter 1
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-330714_10051021279.0DomainABC transmembrane type-1 2
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-33092_3771021279.0DomainABC transmembrane type-1 1
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-3211041_1274102860.0DomainABC transporter 2
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-321410_633102860.0DomainABC transporter 1
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-321714_1005102860.0DomainABC transmembrane type-1 2
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-32192_377102860.0DomainABC transmembrane type-1 1
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-3311322_13251021326.0MotifNote=PDZ-binding
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-3301322_13251021279.0MotifNote=PDZ-binding
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-3211322_1325102860.0MotifNote=PDZ-binding
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-3311075_10821021326.0Nucleotide bindingATP 2
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-331445_4521021326.0Nucleotide bindingATP 1
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-3301075_10821021279.0Nucleotide bindingATP 2
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-330445_4521021279.0Nucleotide bindingATP 1
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-3211075_1082102860.0Nucleotide bindingATP 2
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-321445_452102860.0Nucleotide bindingATP 1
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-3311038_10581021326.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-331136_1561021326.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-331207_2271021326.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-331228_2481021326.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-331328_3481021326.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-331351_3711021326.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-331440_4601021326.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-331710_7301021326.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-331771_7911021326.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-331836_8561021326.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-331858_8781021326.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-33193_1131021326.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-331954_9741021326.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000376887-331977_9971021326.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-3301038_10581021279.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-330136_1561021279.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-330207_2271021279.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-330228_2481021279.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-330328_3481021279.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-330351_3711021279.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-330440_4601021279.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-330710_7301021279.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-330771_7911021279.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-330836_8561021279.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-330858_8781021279.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-33093_1131021279.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-330954_9741021279.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000412704-330977_9971021279.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-3211038_1058102860.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-321136_156102860.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-321207_227102860.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-321228_248102860.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-321328_348102860.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-321351_371102860.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-321440_460102860.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-321710_730102860.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-321771_791102860.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-321836_856102860.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-321858_878102860.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-32193_113102860.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-321954_974102860.0TransmembraneHelical
HgeneABCC4chr13:95899228chr13:115070263ENST00000431522-321977_997102860.0TransmembraneHelical
TgeneUPF3Achr13:95899228chr13:115070263ENST00000375299810421_434434477.0RegionNote=Required for association with EIF4A3 and ECJ core components CASC3%2C MAGOH and RBM8A


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Fusion Gene Sequence for ABCC4-UPF3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>291_291_1_ABCC4-UPF3A_ABCC4_chr13_95899228_ENST00000376887_UPF3A_chr13_115070263_ENST00000351487_length(transcript)=1441nt_BP=421nt
GGACAGGCGTGGCGGCCGGAGCCCCAGCATCCCTGCTTGAGGTCCAGGAGCGGAGCCCGCGGCCACCGCCGCCTGATCAGCGCGACCCCG
GCCCGCGCCCGCCCCGCCCGGCAAGATGCTGCCCGTGTACCAGGAGGTGAAGCCCAACCCGCTGCAGGACGCGAACCTCTGCTCACGCGT
GTTCTTCTGGTGGCTCAATCCCTTGTTTAAAATTGGCCATAAACGGAGATTAGAGGAAGATGATATGTATTCAGTGCTGCCAGAAGACCG
CTCACAGCACCTTGGAGAGGAGTTGCAAGGGTTCTGGGATAAAGAAGTTTTAAGAGCTGAGAATGACGCACAGAAGCCTTCTTTAACAAG
AGCAATCATAAAGTGTTACTGGAAATCTTATTTAGTTTTGGGAATTTTTACGTTAATTGAGGACCGGCCAGCCTTGCAGCTGTATGATCC
AGGAGCTCGCTTCCGAGCGCGAGAGTGTGGCGGAAACAGGAGGATCTGCAAGGCAGAAGGTTCGGGGACTGGTCCTGAGAAGAGGGAAGA
GGCAGAGTGAGTCACTGCACGCACCTGGCCTCCATGGACGAGCAAGGGCATCCCAGAAACGTGTAAATGACCCCGAGTGTGACTGGGAAG
GAGAACTTATTCCTTACCAGGAAACTGGAAGCTAAAAATACAGAGGGTGACGTAGAAACACGCAGAAACCATTCTAAAGAAAGTAGTGAT
CTTGTATTAAATTGAGCAGAATTCTCACAGATTTTACCATTCCTGTTATAAACTAGTATTTGTTGTTTAGCCAAAACAGAAAATGATTTC
CACTGGACAGTAGAAAAATATGTGTAAAATAGGGAAGAAAGTTAGTATTGGATCAGTGTGAGTCCTGAAGCACTTTCAGTGCTGTGAGAA
CGACATCCACTTTGGGTTTCATTCGTTTGTAAGCAGAGGAGCTGTCAGTCACTCGTGCTTCTCGGTGGCCTCTGAGCCATGGTGTCGAGT
GAAGAGTAGTTCTTGTTTGTTACAACCTTTGTGAGTCAGCCATGCCCGCAAAGCGTGCTGTGTTTTAGTCCTGGTAGGAATATTTATCAG
AGTTCACACTATATAAAACCCAACAGCTTCAACTATTGCCCTTTCAACAGTTTTGCCACTGACCGGATAGAAACGGTTTCAGTCTCTGGA
TGGATGTGTTTGTGGTTTGTAACCATTACGGTTTAAACCATGGTTTAAGAATTTGCCCAAATAACAGAAATTTTGTTCGGGAAGGGATAA
ACTAGATATAGCATACAGAGCCTGTTTTTGAGTTTTAGATACTTTATTTGTAAATAACTTAAAATAGCTTTCTGAAACCGTGCATTCTGT
AGTTTCTTCCTTTCAGTGAAATTGCTAAATGTCAATGTATTTTTGGCACTGCGATTTTAACCATTTATTAAATAAAAATTTTGTTAAAGA

>291_291_1_ABCC4-UPF3A_ABCC4_chr13_95899228_ENST00000376887_UPF3A_chr13_115070263_ENST00000351487_length(amino acids)=144AA_BP=102
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK

--------------------------------------------------------------
>291_291_2_ABCC4-UPF3A_ABCC4_chr13_95899228_ENST00000376887_UPF3A_chr13_115070263_ENST00000375299_length(transcript)=1441nt_BP=421nt
GGACAGGCGTGGCGGCCGGAGCCCCAGCATCCCTGCTTGAGGTCCAGGAGCGGAGCCCGCGGCCACCGCCGCCTGATCAGCGCGACCCCG
GCCCGCGCCCGCCCCGCCCGGCAAGATGCTGCCCGTGTACCAGGAGGTGAAGCCCAACCCGCTGCAGGACGCGAACCTCTGCTCACGCGT
GTTCTTCTGGTGGCTCAATCCCTTGTTTAAAATTGGCCATAAACGGAGATTAGAGGAAGATGATATGTATTCAGTGCTGCCAGAAGACCG
CTCACAGCACCTTGGAGAGGAGTTGCAAGGGTTCTGGGATAAAGAAGTTTTAAGAGCTGAGAATGACGCACAGAAGCCTTCTTTAACAAG
AGCAATCATAAAGTGTTACTGGAAATCTTATTTAGTTTTGGGAATTTTTACGTTAATTGAGGACCGGCCAGCCTTGCAGCTGTATGATCC
AGGAGCTCGCTTCCGAGCGCGAGAGTGTGGCGGAAACAGGAGGATCTGCAAGGCAGAAGGTTCGGGGACTGGTCCTGAGAAGAGGGAAGA
GGCAGAGTGAGTCACTGCACGCACCTGGCCTCCATGGACGAGCAAGGGCATCCCAGAAACGTGTAAATGACCCCGAGTGTGACTGGGAAG
GAGAACTTATTCCTTACCAGGAAACTGGAAGCTAAAAATACAGAGGGTGACGTAGAAACACGCAGAAACCATTCTAAAGAAAGTAGTGAT
CTTGTATTAAATTGAGCAGAATTCTCACAGATTTTACCATTCCTGTTATAAACTAGTATTTGTTGTTTAGCCAAAACAGAAAATGATTTC
CACTGGACAGTAGAAAAATATGTGTAAAATAGGGAAGAAAGTTAGTATTGGATCAGTGTGAGTCCTGAAGCACTTTCAGTGCTGTGAGAA
CGACATCCACTTTGGGTTTCATTCGTTTGTAAGCAGAGGAGCTGTCAGTCACTCGTGCTTCTCGGTGGCCTCTGAGCCATGGTGTCGAGT
GAAGAGTAGTTCTTGTTTGTTACAACCTTTGTGAGTCAGCCATGCCCGCAAAGCGTGCTGTGTTTTAGTCCTGGTAGGAATATTTATCAG
AGTTCACACTATATAAAACCCAACAGCTTCAACTATTGCCCTTTCAACAGTTTTGCCACTGACCGGATAGAAACGGTTTCAGTCTCTGGA
TGGATGTGTTTGTGGTTTGTAACCATTACGGTTTAAACCATGGTTTAAGAATTTGCCCAAATAACAGAAATTTTGTTCGGGAAGGGATAA
ACTAGATATAGCATACAGAGCCTGTTTTTGAGTTTTAGATACTTTATTTGTAAATAACTTAAAATAGCTTTCTGAAACCGTGCATTCTGT
AGTTTCTTCCTTTCAGTGAAATTGCTAAATGTCAATGTATTTTTGGCACTGCGATTTTAACCATTTATTAAATAAAAATTTTGTTAAAGA

>291_291_2_ABCC4-UPF3A_ABCC4_chr13_95899228_ENST00000376887_UPF3A_chr13_115070263_ENST00000375299_length(amino acids)=144AA_BP=102
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK

--------------------------------------------------------------
>291_291_3_ABCC4-UPF3A_ABCC4_chr13_95899228_ENST00000412704_UPF3A_chr13_115070263_ENST00000351487_length(transcript)=1445nt_BP=425nt
GAGCGGACAGGCGTGGCGGCCGGAGCCCCAGCATCCCTGCTTGAGGTCCAGGAGCGGAGCCCGCGGCCACCGCCGCCTGATCAGCGCGAC
CCCGGCCCGCGCCCGCCCCGCCCGGCAAGATGCTGCCCGTGTACCAGGAGGTGAAGCCCAACCCGCTGCAGGACGCGAACCTCTGCTCAC
GCGTGTTCTTCTGGTGGCTCAATCCCTTGTTTAAAATTGGCCATAAACGGAGATTAGAGGAAGATGATATGTATTCAGTGCTGCCAGAAG
ACCGCTCACAGCACCTTGGAGAGGAGTTGCAAGGGTTCTGGGATAAAGAAGTTTTAAGAGCTGAGAATGACGCACAGAAGCCTTCTTTAA
CAAGAGCAATCATAAAGTGTTACTGGAAATCTTATTTAGTTTTGGGAATTTTTACGTTAATTGAGGACCGGCCAGCCTTGCAGCTGTATG
ATCCAGGAGCTCGCTTCCGAGCGCGAGAGTGTGGCGGAAACAGGAGGATCTGCAAGGCAGAAGGTTCGGGGACTGGTCCTGAGAAGAGGG
AAGAGGCAGAGTGAGTCACTGCACGCACCTGGCCTCCATGGACGAGCAAGGGCATCCCAGAAACGTGTAAATGACCCCGAGTGTGACTGG
GAAGGAGAACTTATTCCTTACCAGGAAACTGGAAGCTAAAAATACAGAGGGTGACGTAGAAACACGCAGAAACCATTCTAAAGAAAGTAG
TGATCTTGTATTAAATTGAGCAGAATTCTCACAGATTTTACCATTCCTGTTATAAACTAGTATTTGTTGTTTAGCCAAAACAGAAAATGA
TTTCCACTGGACAGTAGAAAAATATGTGTAAAATAGGGAAGAAAGTTAGTATTGGATCAGTGTGAGTCCTGAAGCACTTTCAGTGCTGTG
AGAACGACATCCACTTTGGGTTTCATTCGTTTGTAAGCAGAGGAGCTGTCAGTCACTCGTGCTTCTCGGTGGCCTCTGAGCCATGGTGTC
GAGTGAAGAGTAGTTCTTGTTTGTTACAACCTTTGTGAGTCAGCCATGCCCGCAAAGCGTGCTGTGTTTTAGTCCTGGTAGGAATATTTA
TCAGAGTTCACACTATATAAAACCCAACAGCTTCAACTATTGCCCTTTCAACAGTTTTGCCACTGACCGGATAGAAACGGTTTCAGTCTC
TGGATGGATGTGTTTGTGGTTTGTAACCATTACGGTTTAAACCATGGTTTAAGAATTTGCCCAAATAACAGAAATTTTGTTCGGGAAGGG
ATAAACTAGATATAGCATACAGAGCCTGTTTTTGAGTTTTAGATACTTTATTTGTAAATAACTTAAAATAGCTTTCTGAAACCGTGCATT
CTGTAGTTTCTTCCTTTCAGTGAAATTGCTAAATGTCAATGTATTTTTGGCACTGCGATTTTAACCATTTATTAAATAAAAATTTTGTTA

>291_291_3_ABCC4-UPF3A_ABCC4_chr13_95899228_ENST00000412704_UPF3A_chr13_115070263_ENST00000351487_length(amino acids)=144AA_BP=102
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK

--------------------------------------------------------------
>291_291_4_ABCC4-UPF3A_ABCC4_chr13_95899228_ENST00000412704_UPF3A_chr13_115070263_ENST00000375299_length(transcript)=1445nt_BP=425nt
GAGCGGACAGGCGTGGCGGCCGGAGCCCCAGCATCCCTGCTTGAGGTCCAGGAGCGGAGCCCGCGGCCACCGCCGCCTGATCAGCGCGAC
CCCGGCCCGCGCCCGCCCCGCCCGGCAAGATGCTGCCCGTGTACCAGGAGGTGAAGCCCAACCCGCTGCAGGACGCGAACCTCTGCTCAC
GCGTGTTCTTCTGGTGGCTCAATCCCTTGTTTAAAATTGGCCATAAACGGAGATTAGAGGAAGATGATATGTATTCAGTGCTGCCAGAAG
ACCGCTCACAGCACCTTGGAGAGGAGTTGCAAGGGTTCTGGGATAAAGAAGTTTTAAGAGCTGAGAATGACGCACAGAAGCCTTCTTTAA
CAAGAGCAATCATAAAGTGTTACTGGAAATCTTATTTAGTTTTGGGAATTTTTACGTTAATTGAGGACCGGCCAGCCTTGCAGCTGTATG
ATCCAGGAGCTCGCTTCCGAGCGCGAGAGTGTGGCGGAAACAGGAGGATCTGCAAGGCAGAAGGTTCGGGGACTGGTCCTGAGAAGAGGG
AAGAGGCAGAGTGAGTCACTGCACGCACCTGGCCTCCATGGACGAGCAAGGGCATCCCAGAAACGTGTAAATGACCCCGAGTGTGACTGG
GAAGGAGAACTTATTCCTTACCAGGAAACTGGAAGCTAAAAATACAGAGGGTGACGTAGAAACACGCAGAAACCATTCTAAAGAAAGTAG
TGATCTTGTATTAAATTGAGCAGAATTCTCACAGATTTTACCATTCCTGTTATAAACTAGTATTTGTTGTTTAGCCAAAACAGAAAATGA
TTTCCACTGGACAGTAGAAAAATATGTGTAAAATAGGGAAGAAAGTTAGTATTGGATCAGTGTGAGTCCTGAAGCACTTTCAGTGCTGTG
AGAACGACATCCACTTTGGGTTTCATTCGTTTGTAAGCAGAGGAGCTGTCAGTCACTCGTGCTTCTCGGTGGCCTCTGAGCCATGGTGTC
GAGTGAAGAGTAGTTCTTGTTTGTTACAACCTTTGTGAGTCAGCCATGCCCGCAAAGCGTGCTGTGTTTTAGTCCTGGTAGGAATATTTA
TCAGAGTTCACACTATATAAAACCCAACAGCTTCAACTATTGCCCTTTCAACAGTTTTGCCACTGACCGGATAGAAACGGTTTCAGTCTC
TGGATGGATGTGTTTGTGGTTTGTAACCATTACGGTTTAAACCATGGTTTAAGAATTTGCCCAAATAACAGAAATTTTGTTCGGGAAGGG
ATAAACTAGATATAGCATACAGAGCCTGTTTTTGAGTTTTAGATACTTTATTTGTAAATAACTTAAAATAGCTTTCTGAAACCGTGCATT
CTGTAGTTTCTTCCTTTCAGTGAAATTGCTAAATGTCAATGTATTTTTGGCACTGCGATTTTAACCATTTATTAAATAAAAATTTTGTTA

>291_291_4_ABCC4-UPF3A_ABCC4_chr13_95899228_ENST00000412704_UPF3A_chr13_115070263_ENST00000375299_length(amino acids)=144AA_BP=102
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK

--------------------------------------------------------------
>291_291_5_ABCC4-UPF3A_ABCC4_chr13_95899228_ENST00000431522_UPF3A_chr13_115070263_ENST00000351487_length(transcript)=1445nt_BP=425nt
GAGCGGACAGGCGTGGCGGCCGGAGCCCCAGCATCCCTGCTTGAGGTCCAGGAGCGGAGCCCGCGGCCACCGCCGCCTGATCAGCGCGAC
CCCGGCCCGCGCCCGCCCCGCCCGGCAAGATGCTGCCCGTGTACCAGGAGGTGAAGCCCAACCCGCTGCAGGACGCGAACCTCTGCTCAC
GCGTGTTCTTCTGGTGGCTCAATCCCTTGTTTAAAATTGGCCATAAACGGAGATTAGAGGAAGATGATATGTATTCAGTGCTGCCAGAAG
ACCGCTCACAGCACCTTGGAGAGGAGTTGCAAGGGTTCTGGGATAAAGAAGTTTTAAGAGCTGAGAATGACGCACAGAAGCCTTCTTTAA
CAAGAGCAATCATAAAGTGTTACTGGAAATCTTATTTAGTTTTGGGAATTTTTACGTTAATTGAGGACCGGCCAGCCTTGCAGCTGTATG
ATCCAGGAGCTCGCTTCCGAGCGCGAGAGTGTGGCGGAAACAGGAGGATCTGCAAGGCAGAAGGTTCGGGGACTGGTCCTGAGAAGAGGG
AAGAGGCAGAGTGAGTCACTGCACGCACCTGGCCTCCATGGACGAGCAAGGGCATCCCAGAAACGTGTAAATGACCCCGAGTGTGACTGG
GAAGGAGAACTTATTCCTTACCAGGAAACTGGAAGCTAAAAATACAGAGGGTGACGTAGAAACACGCAGAAACCATTCTAAAGAAAGTAG
TGATCTTGTATTAAATTGAGCAGAATTCTCACAGATTTTACCATTCCTGTTATAAACTAGTATTTGTTGTTTAGCCAAAACAGAAAATGA
TTTCCACTGGACAGTAGAAAAATATGTGTAAAATAGGGAAGAAAGTTAGTATTGGATCAGTGTGAGTCCTGAAGCACTTTCAGTGCTGTG
AGAACGACATCCACTTTGGGTTTCATTCGTTTGTAAGCAGAGGAGCTGTCAGTCACTCGTGCTTCTCGGTGGCCTCTGAGCCATGGTGTC
GAGTGAAGAGTAGTTCTTGTTTGTTACAACCTTTGTGAGTCAGCCATGCCCGCAAAGCGTGCTGTGTTTTAGTCCTGGTAGGAATATTTA
TCAGAGTTCACACTATATAAAACCCAACAGCTTCAACTATTGCCCTTTCAACAGTTTTGCCACTGACCGGATAGAAACGGTTTCAGTCTC
TGGATGGATGTGTTTGTGGTTTGTAACCATTACGGTTTAAACCATGGTTTAAGAATTTGCCCAAATAACAGAAATTTTGTTCGGGAAGGG
ATAAACTAGATATAGCATACAGAGCCTGTTTTTGAGTTTTAGATACTTTATTTGTAAATAACTTAAAATAGCTTTCTGAAACCGTGCATT
CTGTAGTTTCTTCCTTTCAGTGAAATTGCTAAATGTCAATGTATTTTTGGCACTGCGATTTTAACCATTTATTAAATAAAAATTTTGTTA

>291_291_5_ABCC4-UPF3A_ABCC4_chr13_95899228_ENST00000431522_UPF3A_chr13_115070263_ENST00000351487_length(amino acids)=144AA_BP=102
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK

--------------------------------------------------------------
>291_291_6_ABCC4-UPF3A_ABCC4_chr13_95899228_ENST00000431522_UPF3A_chr13_115070263_ENST00000375299_length(transcript)=1445nt_BP=425nt
GAGCGGACAGGCGTGGCGGCCGGAGCCCCAGCATCCCTGCTTGAGGTCCAGGAGCGGAGCCCGCGGCCACCGCCGCCTGATCAGCGCGAC
CCCGGCCCGCGCCCGCCCCGCCCGGCAAGATGCTGCCCGTGTACCAGGAGGTGAAGCCCAACCCGCTGCAGGACGCGAACCTCTGCTCAC
GCGTGTTCTTCTGGTGGCTCAATCCCTTGTTTAAAATTGGCCATAAACGGAGATTAGAGGAAGATGATATGTATTCAGTGCTGCCAGAAG
ACCGCTCACAGCACCTTGGAGAGGAGTTGCAAGGGTTCTGGGATAAAGAAGTTTTAAGAGCTGAGAATGACGCACAGAAGCCTTCTTTAA
CAAGAGCAATCATAAAGTGTTACTGGAAATCTTATTTAGTTTTGGGAATTTTTACGTTAATTGAGGACCGGCCAGCCTTGCAGCTGTATG
ATCCAGGAGCTCGCTTCCGAGCGCGAGAGTGTGGCGGAAACAGGAGGATCTGCAAGGCAGAAGGTTCGGGGACTGGTCCTGAGAAGAGGG
AAGAGGCAGAGTGAGTCACTGCACGCACCTGGCCTCCATGGACGAGCAAGGGCATCCCAGAAACGTGTAAATGACCCCGAGTGTGACTGG
GAAGGAGAACTTATTCCTTACCAGGAAACTGGAAGCTAAAAATACAGAGGGTGACGTAGAAACACGCAGAAACCATTCTAAAGAAAGTAG
TGATCTTGTATTAAATTGAGCAGAATTCTCACAGATTTTACCATTCCTGTTATAAACTAGTATTTGTTGTTTAGCCAAAACAGAAAATGA
TTTCCACTGGACAGTAGAAAAATATGTGTAAAATAGGGAAGAAAGTTAGTATTGGATCAGTGTGAGTCCTGAAGCACTTTCAGTGCTGTG
AGAACGACATCCACTTTGGGTTTCATTCGTTTGTAAGCAGAGGAGCTGTCAGTCACTCGTGCTTCTCGGTGGCCTCTGAGCCATGGTGTC
GAGTGAAGAGTAGTTCTTGTTTGTTACAACCTTTGTGAGTCAGCCATGCCCGCAAAGCGTGCTGTGTTTTAGTCCTGGTAGGAATATTTA
TCAGAGTTCACACTATATAAAACCCAACAGCTTCAACTATTGCCCTTTCAACAGTTTTGCCACTGACCGGATAGAAACGGTTTCAGTCTC
TGGATGGATGTGTTTGTGGTTTGTAACCATTACGGTTTAAACCATGGTTTAAGAATTTGCCCAAATAACAGAAATTTTGTTCGGGAAGGG
ATAAACTAGATATAGCATACAGAGCCTGTTTTTGAGTTTTAGATACTTTATTTGTAAATAACTTAAAATAGCTTTCTGAAACCGTGCATT
CTGTAGTTTCTTCCTTTCAGTGAAATTGCTAAATGTCAATGTATTTTTGGCACTGCGATTTTAACCATTTATTAAATAAAAATTTTGTTA

>291_291_6_ABCC4-UPF3A_ABCC4_chr13_95899228_ENST00000431522_UPF3A_chr13_115070263_ENST00000375299_length(amino acids)=144AA_BP=102
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK

--------------------------------------------------------------
>291_291_7_ABCC4-UPF3A_ABCC4_chr13_95899228_ENST00000536256_UPF3A_chr13_115070263_ENST00000351487_length(transcript)=1445nt_BP=425nt
GAGCGGACAGGCGTGGCGGCCGGAGCCCCAGCATCCCTGCTTGAGGTCCAGGAGCGGAGCCCGCGGCCACCGCCGCCTGATCAGCGCGAC
CCCGGCCCGCGCCCGCCCCGCCCGGCAAGATGCTGCCCGTGTACCAGGAGGTGAAGCCCAACCCGCTGCAGGACGCGAACCTCTGCTCAC
GCGTGTTCTTCTGGTGGCTCAATCCCTTGTTTAAAATTGGCCATAAACGGAGATTAGAGGAAGATGATATGTATTCAGTGCTGCCAGAAG
ACCGCTCACAGCACCTTGGAGAGGAGTTGCAAGGGTTCTGGGATAAAGAAGTTTTAAGAGCTGAGAATGACGCACAGAAGCCTTCTTTAA
CAAGAGCAATCATAAAGTGTTACTGGAAATCTTATTTAGTTTTGGGAATTTTTACGTTAATTGAGGACCGGCCAGCCTTGCAGCTGTATG
ATCCAGGAGCTCGCTTCCGAGCGCGAGAGTGTGGCGGAAACAGGAGGATCTGCAAGGCAGAAGGTTCGGGGACTGGTCCTGAGAAGAGGG
AAGAGGCAGAGTGAGTCACTGCACGCACCTGGCCTCCATGGACGAGCAAGGGCATCCCAGAAACGTGTAAATGACCCCGAGTGTGACTGG
GAAGGAGAACTTATTCCTTACCAGGAAACTGGAAGCTAAAAATACAGAGGGTGACGTAGAAACACGCAGAAACCATTCTAAAGAAAGTAG
TGATCTTGTATTAAATTGAGCAGAATTCTCACAGATTTTACCATTCCTGTTATAAACTAGTATTTGTTGTTTAGCCAAAACAGAAAATGA
TTTCCACTGGACAGTAGAAAAATATGTGTAAAATAGGGAAGAAAGTTAGTATTGGATCAGTGTGAGTCCTGAAGCACTTTCAGTGCTGTG
AGAACGACATCCACTTTGGGTTTCATTCGTTTGTAAGCAGAGGAGCTGTCAGTCACTCGTGCTTCTCGGTGGCCTCTGAGCCATGGTGTC
GAGTGAAGAGTAGTTCTTGTTTGTTACAACCTTTGTGAGTCAGCCATGCCCGCAAAGCGTGCTGTGTTTTAGTCCTGGTAGGAATATTTA
TCAGAGTTCACACTATATAAAACCCAACAGCTTCAACTATTGCCCTTTCAACAGTTTTGCCACTGACCGGATAGAAACGGTTTCAGTCTC
TGGATGGATGTGTTTGTGGTTTGTAACCATTACGGTTTAAACCATGGTTTAAGAATTTGCCCAAATAACAGAAATTTTGTTCGGGAAGGG
ATAAACTAGATATAGCATACAGAGCCTGTTTTTGAGTTTTAGATACTTTATTTGTAAATAACTTAAAATAGCTTTCTGAAACCGTGCATT
CTGTAGTTTCTTCCTTTCAGTGAAATTGCTAAATGTCAATGTATTTTTGGCACTGCGATTTTAACCATTTATTAAATAAAAATTTTGTTA

>291_291_7_ABCC4-UPF3A_ABCC4_chr13_95899228_ENST00000536256_UPF3A_chr13_115070263_ENST00000351487_length(amino acids)=144AA_BP=102
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK

--------------------------------------------------------------
>291_291_8_ABCC4-UPF3A_ABCC4_chr13_95899228_ENST00000536256_UPF3A_chr13_115070263_ENST00000375299_length(transcript)=1445nt_BP=425nt
GAGCGGACAGGCGTGGCGGCCGGAGCCCCAGCATCCCTGCTTGAGGTCCAGGAGCGGAGCCCGCGGCCACCGCCGCCTGATCAGCGCGAC
CCCGGCCCGCGCCCGCCCCGCCCGGCAAGATGCTGCCCGTGTACCAGGAGGTGAAGCCCAACCCGCTGCAGGACGCGAACCTCTGCTCAC
GCGTGTTCTTCTGGTGGCTCAATCCCTTGTTTAAAATTGGCCATAAACGGAGATTAGAGGAAGATGATATGTATTCAGTGCTGCCAGAAG
ACCGCTCACAGCACCTTGGAGAGGAGTTGCAAGGGTTCTGGGATAAAGAAGTTTTAAGAGCTGAGAATGACGCACAGAAGCCTTCTTTAA
CAAGAGCAATCATAAAGTGTTACTGGAAATCTTATTTAGTTTTGGGAATTTTTACGTTAATTGAGGACCGGCCAGCCTTGCAGCTGTATG
ATCCAGGAGCTCGCTTCCGAGCGCGAGAGTGTGGCGGAAACAGGAGGATCTGCAAGGCAGAAGGTTCGGGGACTGGTCCTGAGAAGAGGG
AAGAGGCAGAGTGAGTCACTGCACGCACCTGGCCTCCATGGACGAGCAAGGGCATCCCAGAAACGTGTAAATGACCCCGAGTGTGACTGG
GAAGGAGAACTTATTCCTTACCAGGAAACTGGAAGCTAAAAATACAGAGGGTGACGTAGAAACACGCAGAAACCATTCTAAAGAAAGTAG
TGATCTTGTATTAAATTGAGCAGAATTCTCACAGATTTTACCATTCCTGTTATAAACTAGTATTTGTTGTTTAGCCAAAACAGAAAATGA
TTTCCACTGGACAGTAGAAAAATATGTGTAAAATAGGGAAGAAAGTTAGTATTGGATCAGTGTGAGTCCTGAAGCACTTTCAGTGCTGTG
AGAACGACATCCACTTTGGGTTTCATTCGTTTGTAAGCAGAGGAGCTGTCAGTCACTCGTGCTTCTCGGTGGCCTCTGAGCCATGGTGTC
GAGTGAAGAGTAGTTCTTGTTTGTTACAACCTTTGTGAGTCAGCCATGCCCGCAAAGCGTGCTGTGTTTTAGTCCTGGTAGGAATATTTA
TCAGAGTTCACACTATATAAAACCCAACAGCTTCAACTATTGCCCTTTCAACAGTTTTGCCACTGACCGGATAGAAACGGTTTCAGTCTC
TGGATGGATGTGTTTGTGGTTTGTAACCATTACGGTTTAAACCATGGTTTAAGAATTTGCCCAAATAACAGAAATTTTGTTCGGGAAGGG
ATAAACTAGATATAGCATACAGAGCCTGTTTTTGAGTTTTAGATACTTTATTTGTAAATAACTTAAAATAGCTTTCTGAAACCGTGCATT
CTGTAGTTTCTTCCTTTCAGTGAAATTGCTAAATGTCAATGTATTTTTGGCACTGCGATTTTAACCATTTATTAAATAAAAATTTTGTTA

>291_291_8_ABCC4-UPF3A_ABCC4_chr13_95899228_ENST00000536256_UPF3A_chr13_115070263_ENST00000375299_length(amino acids)=144AA_BP=102
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ABCC4-UPF3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABCC4-UPF3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABCC4-UPF3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCC4C0003873Rheumatoid Arthritis1CTD_human
HgeneABCC4C0009241Cognition Disorders1CTD_human
HgeneABCC4C0009402Colorectal Carcinoma1CTD_human
HgeneABCC4C0009404Colorectal Neoplasms1CTD_human
HgeneABCC4C0013146Drug abuse1CTD_human
HgeneABCC4C0013170Drug habituation1CTD_human
HgeneABCC4C0013221Drug toxicity1CTD_human
HgeneABCC4C0013222Drug Use Disorders1CTD_human
HgeneABCC4C0014175Endometriosis1CTD_human
HgeneABCC4C0027627Neoplasm Metastasis1CTD_human
HgeneABCC4C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneABCC4C0033578Prostatic Neoplasms1CTD_human
HgeneABCC4C0038580Substance Dependence1CTD_human
HgeneABCC4C0038586Substance Use Disorders1CTD_human
HgeneABCC4C0041755Adverse reaction to drug1CTD_human
HgeneABCC4C0236969Substance-Related Disorders1CTD_human
HgeneABCC4C0269102Endometrioma1CTD_human
HgeneABCC4C0342257Complications of Diabetes Mellitus1CTD_human
HgeneABCC4C0376358Malignant neoplasm of prostate1CTD_human
HgeneABCC4C0740858Substance abuse problem1CTD_human
HgeneABCC4C1510472Drug Dependence1CTD_human
HgeneABCC4C4316881Prescription Drug Abuse1CTD_human