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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:AKAP8-BRD4 (FusionGDB2 ID:HG10270TG23476) |
Fusion Gene Summary for AKAP8-BRD4 |
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Fusion gene information | Fusion gene name: AKAP8-BRD4 | Fusion gene ID: hg10270tg23476 | Hgene | Tgene | Gene symbol | AKAP8 | BRD4 | Gene ID | 10270 | 23476 |
Gene name | A-kinase anchoring protein 8 | bromodomain containing 4 | |
Synonyms | AKAP 95|AKAP-8|AKAP-95|AKAP95 | CAP|HUNK1|HUNKI|MCAP | |
Cytomap | ('AKAP8')('BRD4') 19p13.12 | 19p13.12 | |
Type of gene | protein-coding | protein-coding | |
Description | A-kinase anchor protein 8A kinase (PRKA) anchor protein 8A-kinase anchor protein, 95kDa | bromodomain-containing protein 4chromosome-associated proteinmitotic chromosome-associated protein | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | . | O60885 | |
Ensembl transtripts involved in fusion gene | ENST00000269701, | ||
Fusion gene scores | * DoF score | 13 X 14 X 9=1638 | 15 X 19 X 13=3705 |
# samples | 17 | 28 | |
** MAII score | log2(17/1638*10)=-3.26832870550331 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(28/3705*10)=-3.72597481024823 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: AKAP8 [Title/Abstract] AND BRD4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | AKAP8(15465385)-BRD4(15359824), # samples:1 AKAP8(15487787)-BRD4(15367984), # samples:1 AKAP8(15490524)-BRD4(15367984), # samples:1 AKAP8(15487787)-BRD4(15366403), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | AKAP8-BRD4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AKAP8-BRD4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AKAP8-BRD4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AKAP8-BRD4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AKAP8-BRD4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. AKAP8-BRD4 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. AKAP8-BRD4 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. AKAP8-BRD4 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. AKAP8-BRD4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. AKAP8-BRD4 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | BRD4 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter | 19103749|23086925 |
Tgene | BRD4 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 19103749 |
Tgene | BRD4 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 23086925|23317504|24360279 |
Tgene | BRD4 | GO:0050727 | regulation of inflammatory response | 19103749 |
Tgene | BRD4 | GO:1901407 | regulation of phosphorylation of RNA polymerase II C-terminal domain | 23086925 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BLCA | TCGA-GV-A3QI-01A | AKAP8 | chr19 | 15465385 | - | BRD4 | chr19 | 15359824 | - |
ChimerDB4 | BLCA | TCGA-ZF-AA4V-01A | AKAP8 | chr19 | 15487787 | - | BRD4 | chr19 | 15367984 | - |
ChimerDB4 | BLCA | TCGA-ZF-AA4V-01A | AKAP8 | chr19 | 15490524 | - | BRD4 | chr19 | 15367984 | - |
ChimerDB4 | OV | TCGA-04-1338-01A | AKAP8 | chr19 | 15487787 | - | BRD4 | chr19 | 15366403 | - |
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Fusion Gene ORF analysis for AKAP8-BRD4 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000269701 | ENST00000602230 | AKAP8 | chr19 | 15487787 | - | BRD4 | chr19 | 15367984 | - |
5CDS-5UTR | ENST00000269701 | ENST00000602230 | AKAP8 | chr19 | 15490524 | - | BRD4 | chr19 | 15367984 | - |
5CDS-intron | ENST00000269701 | ENST00000602230 | AKAP8 | chr19 | 15487787 | - | BRD4 | chr19 | 15366403 | - |
Frame-shift | ENST00000269701 | ENST00000263377 | AKAP8 | chr19 | 15487787 | - | BRD4 | chr19 | 15367984 | - |
Frame-shift | ENST00000269701 | ENST00000263377 | AKAP8 | chr19 | 15487787 | - | BRD4 | chr19 | 15366403 | - |
Frame-shift | ENST00000269701 | ENST00000360016 | AKAP8 | chr19 | 15487787 | - | BRD4 | chr19 | 15367984 | - |
Frame-shift | ENST00000269701 | ENST00000360016 | AKAP8 | chr19 | 15487787 | - | BRD4 | chr19 | 15366403 | - |
Frame-shift | ENST00000269701 | ENST00000371835 | AKAP8 | chr19 | 15487787 | - | BRD4 | chr19 | 15367984 | - |
Frame-shift | ENST00000269701 | ENST00000371835 | AKAP8 | chr19 | 15487787 | - | BRD4 | chr19 | 15366403 | - |
In-frame | ENST00000269701 | ENST00000263377 | AKAP8 | chr19 | 15490524 | - | BRD4 | chr19 | 15367984 | - |
In-frame | ENST00000269701 | ENST00000360016 | AKAP8 | chr19 | 15490524 | - | BRD4 | chr19 | 15367984 | - |
In-frame | ENST00000269701 | ENST00000371835 | AKAP8 | chr19 | 15490524 | - | BRD4 | chr19 | 15367984 | - |
intron-3UTR | ENST00000269701 | ENST00000371835 | AKAP8 | chr19 | 15465385 | - | BRD4 | chr19 | 15359824 | - |
intron-intron | ENST00000269701 | ENST00000263377 | AKAP8 | chr19 | 15465385 | - | BRD4 | chr19 | 15359824 | - |
intron-intron | ENST00000269701 | ENST00000360016 | AKAP8 | chr19 | 15465385 | - | BRD4 | chr19 | 15359824 | - |
intron-intron | ENST00000269701 | ENST00000602230 | AKAP8 | chr19 | 15465385 | - | BRD4 | chr19 | 15359824 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000269701 | AKAP8 | chr19 | 15490524 | - | ENST00000263377 | BRD4 | chr19 | 15367984 | - | 4369 | 80 | 14 | 2827 | 937 |
ENST00000269701 | AKAP8 | chr19 | 15490524 | - | ENST00000371835 | BRD4 | chr19 | 15367984 | - | 3131 | 80 | 14 | 907 | 297 |
ENST00000269701 | AKAP8 | chr19 | 15490524 | - | ENST00000360016 | BRD4 | chr19 | 15367984 | - | 1689 | 80 | 14 | 1123 | 369 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000269701 | ENST00000263377 | AKAP8 | chr19 | 15490524 | - | BRD4 | chr19 | 15367984 | - | 0.010930412 | 0.98906964 |
ENST00000269701 | ENST00000371835 | AKAP8 | chr19 | 15490524 | - | BRD4 | chr19 | 15367984 | - | 0.00372581 | 0.99627423 |
ENST00000269701 | ENST00000360016 | AKAP8 | chr19 | 15490524 | - | BRD4 | chr19 | 15367984 | - | 0.007903014 | 0.992097 |
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Fusion Genomic Features for AKAP8-BRD4 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for AKAP8-BRD4 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:15465385/chr19:15359824) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | BRD4 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:23589332, PubMed:23317504, PubMed:22334664). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters. Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6. BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:23589332, PubMed:19596240, PubMed:16109377, PubMed:16109376, PubMed:24360279). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 1011_1014 | 447 | 1363.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 1028_1033 | 447 | 1363.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 1283_1300 | 447 | 1363.0 | Compositional bias | Note=Poly-Gln | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 1301_1308 | 447 | 1363.0 | Compositional bias | Note=Poly-Ala | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 1335_1338 | 447 | 1363.0 | Compositional bias | Note=Poly-Arg | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 535_594 | 447 | 1363.0 | Compositional bias | Note=Lys-rich | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 692_717 | 447 | 1363.0 | Compositional bias | Note=Ser-rich | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 703_714 | 447 | 1363.0 | Compositional bias | Note=Poly-Ser | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 738_743 | 447 | 1363.0 | Compositional bias | Note=Poly-His | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 757_761 | 447 | 1363.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 764_770 | 447 | 1363.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 771_775 | 447 | 1363.0 | Compositional bias | Note=Poly-Gln | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 776_783 | 447 | 1363.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 954_964 | 447 | 1363.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 974_986 | 447 | 1363.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 1011_1014 | 447 | 795.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 1028_1033 | 447 | 795.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 1283_1300 | 447 | 795.0 | Compositional bias | Note=Poly-Gln | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 1301_1308 | 447 | 795.0 | Compositional bias | Note=Poly-Ala | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 1335_1338 | 447 | 795.0 | Compositional bias | Note=Poly-Arg | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 535_594 | 447 | 795.0 | Compositional bias | Note=Lys-rich | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 692_717 | 447 | 795.0 | Compositional bias | Note=Ser-rich | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 703_714 | 447 | 795.0 | Compositional bias | Note=Poly-Ser | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 738_743 | 447 | 795.0 | Compositional bias | Note=Poly-His | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 757_761 | 447 | 795.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 764_770 | 447 | 795.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 771_775 | 447 | 795.0 | Compositional bias | Note=Poly-Gln | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 776_783 | 447 | 795.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 954_964 | 447 | 795.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 974_986 | 447 | 795.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 1011_1014 | 447 | 723.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 1028_1033 | 447 | 723.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 1283_1300 | 447 | 723.0 | Compositional bias | Note=Poly-Gln | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 1301_1308 | 447 | 723.0 | Compositional bias | Note=Poly-Ala | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 1335_1338 | 447 | 723.0 | Compositional bias | Note=Poly-Arg | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 535_594 | 447 | 723.0 | Compositional bias | Note=Lys-rich | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 692_717 | 447 | 723.0 | Compositional bias | Note=Ser-rich | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 703_714 | 447 | 723.0 | Compositional bias | Note=Poly-Ser | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 738_743 | 447 | 723.0 | Compositional bias | Note=Poly-His | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 757_761 | 447 | 723.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 764_770 | 447 | 723.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 771_775 | 447 | 723.0 | Compositional bias | Note=Poly-Gln | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 776_783 | 447 | 723.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 954_964 | 447 | 723.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 974_986 | 447 | 723.0 | Compositional bias | Note=Poly-Pro | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 600_682 | 447 | 1363.0 | Domain | NET | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 600_682 | 447 | 795.0 | Domain | NET | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 600_682 | 447 | 723.0 | Domain | NET | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 1047_1362 | 447 | 1363.0 | Region | Note=C-terminal (CTD) region | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 484_503 | 447 | 1363.0 | Region | Note=NPS region | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 524_579 | 447 | 1363.0 | Region | Note=BID region | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 1047_1362 | 447 | 795.0 | Region | Note=C-terminal (CTD) region | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 484_503 | 447 | 795.0 | Region | Note=NPS region | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 524_579 | 447 | 795.0 | Region | Note=BID region | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 1047_1362 | 447 | 723.0 | Region | Note=C-terminal (CTD) region | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 484_503 | 447 | 723.0 | Region | Note=NPS region | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 524_579 | 447 | 723.0 | Region | Note=BID region |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | AKAP8 | chr19:15490524 | chr19:15367984 | ENST00000269701 | - | 1 | 14 | 107_118 | 6 | 693.0 | Compositional bias | Note=Poly-Gly |
Hgene | AKAP8 | chr19:15490524 | chr19:15367984 | ENST00000269701 | - | 1 | 14 | 289_306 | 6 | 693.0 | Motif | Bipartite nuclear localization signal |
Hgene | AKAP8 | chr19:15490524 | chr19:15367984 | ENST00000269701 | - | 1 | 14 | 387_450 | 6 | 693.0 | Region | Involved in chromatin-binding |
Hgene | AKAP8 | chr19:15490524 | chr19:15367984 | ENST00000269701 | - | 1 | 14 | 525_569 | 6 | 693.0 | Region | Involved in condensin complex recruitment |
Hgene | AKAP8 | chr19:15490524 | chr19:15367984 | ENST00000269701 | - | 1 | 14 | 572_589 | 6 | 693.0 | Region | RII-binding |
Hgene | AKAP8 | chr19:15490524 | chr19:15367984 | ENST00000269701 | - | 1 | 14 | 392_414 | 6 | 693.0 | Zinc finger | C2H2 AKAP95-type 1 |
Hgene | AKAP8 | chr19:15490524 | chr19:15367984 | ENST00000269701 | - | 1 | 14 | 481_504 | 6 | 693.0 | Zinc finger | C2H2 AKAP95-type 2 |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 368_440 | 447 | 1363.0 | Domain | Bromo 2 | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000263377 | 6 | 20 | 75_147 | 447 | 1363.0 | Domain | Bromo 1 | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 368_440 | 447 | 795.0 | Domain | Bromo 2 | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000360016 | 6 | 12 | 75_147 | 447 | 795.0 | Domain | Bromo 1 | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 368_440 | 447 | 723.0 | Domain | Bromo 2 | |
Tgene | BRD4 | chr19:15490524 | chr19:15367984 | ENST00000371835 | 6 | 12 | 75_147 | 447 | 723.0 | Domain | Bromo 1 |
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Fusion Gene Sequence for AKAP8-BRD4 |
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>3365_3365_1_AKAP8-BRD4_AKAP8_chr19_15490524_ENST00000269701_BRD4_chr19_15367984_ENST00000263377_length(transcript)=4369nt_BP=80nt TGAACGCATGCGTGCTGTGGTCGCCTAGTAAACGGGGCTGCTGGTGGGCCGCGTCGAAGACATGGACCAGGGCTACGGAGGATGTGTTCG AAATGCGCTTTGCCAAGATGCCGGACGAGCCTGAGGAGCCAGTGGTGGCCGTGTCCTCCCCGGCAGTGCCCCCTCCCACCAAGGTTGTGG CCCCGCCCTCATCCAGCGACAGCAGCAGCGATAGCTCCTCGGACAGTGACAGTTCGACTGATGACTCTGAGGAGGAGCGAGCCCAGCGGC TGGCTGAGCTCCAGGAGCAGCTCAAAGCCGTGCACGAGCAGCTTGCAGCCCTCTCTCAGCCCCAGCAGAACAAACCAAAGAAAAAGGAGA AAGACAAGAAGGAAAAGAAAAAAGAAAAGCACAAAAGGAAAGAGGAAGTGGAAGAGAATAAAAAAAGCAAAGCCAAGGAACCTCCTCCTA AAAAGACGAAGAAAAATAATAGCAGCAACAGCAATGTGAGCAAGAAGGAGCCAGCGCCCATGAAGAGCAAGCCCCCTCCCACGTATGAGT CGGAGGAAGAGGACAAGTGCAAGCCTATGTCCTATGAGGAGAAGCGGCAGCTCAGCTTGGACATCAACAAGCTCCCCGGCGAGAAGCTGG GCCGCGTGGTGCACATCATCCAGTCACGGGAGCCCTCCCTGAAGAATTCCAACCCCGACGAGATTGAAATCGACTTTGAGACCCTGAAGC CGTCCACACTGCGTGAGCTGGAGCGCTATGTCACCTCCTGTTTGCGGAAGAAAAGGAAACCTCAAGCTGAGAAAGTTGATGTGATTGCCG GCTCCTCCAAGATGAAGGGCTTCTCGTCCTCAGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACAGAGA TGGCTCCGAAGTCAAAAAAGAAGGGGCACCCCGGGAGGGAGCAGAAGAAGCACCATCATCACCACCATCAGCAGATGCAGCAGGCCCCGG CTCCTGTGCCCCAGCAGCCGCCCCCGCCTCCCCAGCAGCCCCCACCGCCTCCACCTCCGCAGCAGCAACAGCAGCCGCCACCCCCGCCTC CCCCACCCTCCATGCCGCAGCAGGCAGCCCCGGCGATGAAGTCCTCGCCCCCACCCTTCATTGCCACCCAGGTGCCCGTCCTGGAGCCCC AGCTCCCAGGCAGCGTCTTTGACCCCATCGGCCACTTCACCCAGCCCATCCTGCACCTGCCGCAGCCTGAGCTGCCCCCTCACCTGCCCC AGCCGCCTGAGCACAGCACTCCACCCCATCTCAACCAGCACGCAGTGGTCTCTCCTCCAGCTTTGCACAACGCACTACCCCAGCAGCCAT CACGGCCCAGCAACCGAGCCGCTGCCCTGCCTCCCAAGCCCGCCCGGCCCCCAGCCGTGTCACCAGCCTTGACCCAAACACCCCTGCTCC CACAGCCCCCCATGGCCCAACCCCCCCAAGTGCTGCTGGAGGATGAAGAGCCACCTGCCCCACCCCTCACCTCCATGCAGATGCAGCTGT ACCTGCAGCAGCTGCAGAAGGTGCAGCCCCCTACGCCGCTACTCCCTTCCGTGAAGGTGCAGTCCCAGCCCCCACCCCCCCTGCCGCCCC CACCCCACCCCTCTGTGCAGCAGCAGCTGCAGCAGCAGCCGCCACCACCCCCACCACCCCAGCCCCAGCCTCCACCCCAGCAGCAGCATC AGCCCCCTCCACGGCCCGTGCACTTGCAGCCCATGCAGTTTTCCACCCACATCCAACAGCCCCCGCCACCCCAGGGCCAGCAGCCCCCCC ATCCGCCCCCAGGCCAGCAGCCACCCCCGCCGCAGCCTGCCAAGCCTCAGCAAGTCATCCAGCACCACCATTCACCCCGGCACCACAAGT CGGACCCCTACTCAACCGGTCACCTCCGCGAAGCCCCCTCCCCGCTTATGATACATTCCCCCCAGATGTCACAGTTCCAGAGCCTGACCC ACCAGTCTCCACCCCAGCAAAACGTCCAGCCTAAGAAACAGGAGCTGCGTGCTGCCTCCGTGGTCCAGCCCCAGCCCCTCGTGGTGGTGA AGGAGGAGAAGATCCACTCACCCATCATCCGCAGCGAGCCCTTCAGCCCCTCGCTGCGGCCGGAGCCCCCCAAGCACCCGGAGAGCATCA AGGCCCCCGTCCACCTGCCCCAGCGGCCGGAAATGAAGCCTGTGGATGTCGGGAGGCCTGTGATCCGGCCCCCAGAGCAGAACGCACCGC CACCAGGGGCCCCTGACAAGGACAAACAGAAACAGGAGCCGAAGACTCCAGTTGCGCCCAAAAAGGACCTGAAAATCAAGAACATGGGCT CCTGGGCCAGCCTAGTGCAGAAGCATCCGACCACCCCCTCCTCCACAGCCAAGTCATCCAGCGACAGCTTCGAGCAGTTCCGCCGCGCCG CTCGGGAGAAAGAGGAGCGTGAGAAGGCCCTGAAGGCTCAGGCCGAGCACGCTGAGAAGGAGAAGGAGCGGCTGCGGCAGGAGCGCATGA GGAGCCGAGAGGACGAGGATGCGCTGGAGCAGGCCCGGCGGGCCCATGAGGAGGCACGTCGGCGCCAGGAGCAGCAGCAGCAGCAGCGCC AGGAGCAACAGCAGCAGCAGCAACAGCAAGCAGCTGCGGTGGCTGCCGCCGCCACCCCACAGGCCCAGAGCTCCCAGCCCCAGTCCATGC TGGACCAGCAGAGGGAGTTGGCCCGGAAGCGGGAGCAGGAGCGAAGACGCCGGGAAGCCATGGCAGCTACCATTGACATGAATTTCCAGA GTGATCTATTGTCAATATTTGAAGAAAATCTTTTCTGAGCGCACCTAGGTGGCTTCTGACTTTGATTTTCTGGCAAAACATTGACTTTCC ATAGTGTTAGGGGCGGTGGTGGAGGTGGGATCAGCGGCCAGGGGATGCCTCAGGGCCTGGCCCTCCTGCATGCTATGCCCGGGGCAGGCC TGACGGGCAGCTGAGGATTGCAGAGCCTGTCTGCCTTACGGCCAGTCGGACAGACGTCCCGCCACCCACCACCCCTCACAGGACGTCCGC TCAGCACACGCCTTGTTACGAGCAAGTGCCGGCTGGACCCAAGCCCTGCATCCCCACATGCGGGGCAGAGGCCCTTCTCTCCGCCAAATG TCTACACAGTATACACAGGACATCGTTGCTGCCGCCGTGACTGGTTTTCTGTCCCCAAGAACGTGACGTTCGTGATGTCCTGCCCGCCGG GAGTCTTTCCCCACACCCCAGCCATCGCCGCCCGCTCCCAGGAGGCCAGGGCAGGCCTGCGTGGGCTGGAGGCGGGCGAGGCCGGCCCAC CCCCTCGCTGGCACTGACTTTGCCTTGAACAGACCCCCCGACCCTCCCCCACAAGCCTTTAATTGAGAGCCGCTCTCTGTAAGTGTTTGC TTGTGCAAAAGGGAATAGTGCCGTGGAGGTGTGTGTGTCCATGGCATCCGGAGCGAGGCGACTGTCCTGCGTGGGTAGCCCTCGGCCGGG GAGTGAGGCCACCAACCAAAGTCAGTTCCTTCCCACCTGTGTTTCTGTTTCGTTTTTTTTTTTCTTTTTTTTCTATATATATTTTTTGTT GAATTCTATTTTATTTTTAATTCTCTCTTCTCCTCCAGACACAATGGCACTGCTTATCTCCGAAATGGTGTGATCGTCTCCTCATTGAGC AGCGGCTGCCACCGCGCTGTGGGTAGTGTGTGACCGTGGCTGTACTGTATAGTGAACATAGTTGGCATATCTTTGTTTGAAGTTTGTTGG TGACTCCACCAAACTGGTGTGAAAAAAGAAAAAAGCTCAAAAAAATCCACAAAAAGACAAAACACACAAAAAAAATCCTGCCTATATTTT ACTCAGTTTCAAACTTTATTAGTCTATTTTTAATTATAAAACCAGAAAGCTACAATTTCTTTTCTTTCCCCTCCACCCCCCCCCCCCCCA CCCATTTGTTGGCTTTTTTGTTTTTTAATGTCAGATCTGTTGAGTTGGTTTTTTTGGTTTTGGTTTTTGTTTTTGTTTTTGTTTTTTACT GAGAAAGGAAGGGCCAAGGGATGAGGTGGGAACCGGGCCCTGGGGGCGCCACAGACTAAGGCAGAGACTCCCCTACCTGGCGCCCAGCCC CAACCAGCTGGCCGCTCCTGCCCATGCTTTTTTTTTTTTTTTTTTTTAATTTTTATAATTGGAGCCCCTGGTGAGGTTACGCGTGCCATG AGAACCCACTCTACACCACGACGCTGGTGCCTCAGTGTTGGCCAAACTCTGGAGTCACTGACTGGTTTGACTTTCATACGGTGAATATGC >3365_3365_1_AKAP8-BRD4_AKAP8_chr19_15490524_ENST00000269701_BRD4_chr19_15367984_ENST00000263377_length(amino acids)=937AA_BP=547 MWSPSKRGCWWAASKTWTRATEDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQ EQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEED KCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKM KGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSM PQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSN RAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPS VQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYS TGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESIKAPVH LPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKE EREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSMLDQQR -------------------------------------------------------------- >3365_3365_2_AKAP8-BRD4_AKAP8_chr19_15490524_ENST00000269701_BRD4_chr19_15367984_ENST00000360016_length(transcript)=1689nt_BP=80nt TGAACGCATGCGTGCTGTGGTCGCCTAGTAAACGGGGCTGCTGGTGGGCCGCGTCGAAGACATGGACCAGGGCTACGGAGGATGTGTTCG AAATGCGCTTTGCCAAGATGCCGGACGAGCCTGAGGAGCCAGTGGTGGCCGTGTCCTCCCCGGCAGTGCCCCCTCCCACCAAGGTTGTGG CCCCGCCCTCATCCAGCGACAGCAGCAGCGATAGCTCCTCGGACAGTGACAGTTCGACTGATGACTCTGAGGAGGAGCGAGCCCAGCGGC TGGCTGAGCTCCAGGAGCAGCTCAAAGCCGTGCACGAGCAGCTTGCAGCCCTCTCTCAGCCCCAGCAGAACAAACCAAAGAAAAAGGAGA AAGACAAGAAGGAAAAGAAAAAAGAAAAGCACAAAAGGAAAGAGGAAGTGGAAGAGAATAAAAAAAGCAAAGCCAAGGAACCTCCTCCTA AAAAGACGAAGAAAAATAATAGCAGCAACAGCAATGTGAGCAAGAAGGAGCCAGCGCCCATGAAGAGCAAGCCCCCTCCCACGTATGAGT CGGAGGAAGAGGACAAGTGCAAGCCTATGTCCTATGAGGAGAAGCGGCAGCTCAGCTTGGACATCAACAAGCTCCCCGGCGAGAAGCTGG GCCGCGTGGTGCACATCATCCAGTCACGGGAGCCCTCCCTGAAGAATTCCAACCCCGACGAGATTGAAATCGACTTTGAGACCCTGAAGC CGTCCACACTGCGTGAGCTGGAGCGCTATGTCACCTCCTGTTTGCGGAAGAAAAGGAAACCTCAAGCTGAGAAAGTTGATGTGATTGCCG GCTCCTCCAAGATGAAGGGCTTCTCGTCCTCAGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACAGCTT TCTGCACCAGTGGAGACTTCGTGTCCCCAGGGCCTTCCCCGTATCACAGTCACGTGCAGTGCGGCCGCTTCAGGGAGATGCTTCGCTGGT TTCTGGTGGATGTGGAGCAGACTGCAGCTGGCCAGCCGCATCGCCAGTCTGCTGCTGGCCCTGCCATCACCTGGGCCCCAGCCATTGCCT ACCCCTCCCCAGAGTGTGCTCGTTGCTGTGTTGGCTGCTCCTGAATCTGCCCTAACTCCACACGCACCTGGACTTGCGTGTCCCTCCTGC AGTTCTAACTAACAGTCCCTTCTTTTCAAGCCCCGTGGGTCTGCACGTTGGACCCTGGGTTCCCCATTAGAGCCCACCTTCTGAGCAGCA GCCTCAGTGGGAGGTGGAGGCAGGTAGTGATGCTGGGTGCCAGGTGGGAGTGGAGAGGGGACTGCTCTCCTCCAAGTGTGCACTTTCCTC ATTATTCTCAGGGGCGCAGATGCTCAGGCTGGCGCAGGGGAGAGGCTAGGGAGGGAGCCATGGTGCCCAGAAGGCCTGGCGACCAGCCCC TGCTGAGAGATGGAGCTAACATCCTGTGTTTACGGCCAACGGGGTTGCCGCTAGGCTGGTGCAGCTGTCAGTGAGCTGGCGTGCTGCAGA CCACCTGAGAGCTGGCCCTAGGGTCTCAGGCAGACTGGGGAGTGGGGATCCACAGTGGGAAACCTGTGTTTTGGCAGTAGACTCCTGCAT >3365_3365_2_AKAP8-BRD4_AKAP8_chr19_15490524_ENST00000269701_BRD4_chr19_15367984_ENST00000360016_length(amino acids)=369AA_BP=1 MWSPSKRGCWWAASKTWTRATEDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQ EQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEED KCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKM KGFSSSESESSSESSSSDSEDSETAFCTSGDFVSPGPSPYHSHVQCGRFREMLRWFLVDVEQTAAGQPHRQSAAGPAITWAPAIAYPSPE -------------------------------------------------------------- >3365_3365_3_AKAP8-BRD4_AKAP8_chr19_15490524_ENST00000269701_BRD4_chr19_15367984_ENST00000371835_length(transcript)=3131nt_BP=80nt TGAACGCATGCGTGCTGTGGTCGCCTAGTAAACGGGGCTGCTGGTGGGCCGCGTCGAAGACATGGACCAGGGCTACGGAGGATGTGTTCG AAATGCGCTTTGCCAAGATGCCGGACGAGCCTGAGGAGCCAGTGGTGGCCGTGTCCTCCCCGGCAGTGCCCCCTCCCACCAAGGTTGTGG CCCCGCCCTCATCCAGCGACAGCAGCAGCGATAGCTCCTCGGACAGTGACAGTTCGACTGATGACTCTGAGGAGGAGCGAGCCCAGCGGC TGGCTGAGCTCCAGGAGCAGCTCAAAGCCGTGCACGAGCAGCTTGCAGCCCTCTCTCAGCCCCAGCAGAACAAACCAAAGAAAAAGGAGA AAGACAAGAAGGAAAAGAAAAAAGAAAAGCACAAAAGGAAAGAGGAAGTGGAAGAGAATAAAAAAAGCAAAGCCAAGGAACCTCCTCCTA AAAAGACGAAGAAAAATAATAGCAGCAACAGCAATGTGAGCAAGAAGGAGCCAGCGCCCATGAAGAGCAAGCCCCCTCCCACGTATGAGT CGGAGGAAGAGGACAAGTGCAAGCCTATGTCCTATGAGGAGAAGCGGCAGCTCAGCTTGGACATCAACAAGCTCCCCGGCGAGAAGCTGG GCCGCGTGGTGCACATCATCCAGTCACGGGAGCCCTCCCTGAAGAATTCCAACCCCGACGAGATTGAAATCGACTTTGAGACCCTGAAGC CGTCCACACTGCGTGAGCTGGAGCGCTATGTCACCTCCTGTTTGCGGAAGAAAAGGAAACCTCAAGCTGAGAAAGTTGATGTGATTGCCG GCTCCTCCAAGATGAAGGGCTTCTCGTCCTCAGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACAGGTC CTGCCTAATCATTGGACACGGACTCTTAATAAAACGGTCTTCAGTTCCAGATTCCTTCCCAGCAAGCTATAGCTTAAGTCCATTTTCTTC CGTGAAAGGGACAGGACTCCATCAAGTTATGGAATTCCTCAGAGCCCTGGGCCTGTCCCCCGGGGTGGATTAGTCATGTCCAGCAGCACA CGCCTAGTCCCGCCTTCGGGAAGGCTGCCTGCCTGGCCAGCCGCCCAGGCCTCTCTGTGTAAAGACTGCCTGGCTGTCCTGCCCAGCCTT CCTGGTTCTCTGGGGTCCTCTGGGTGGGTGGCATCTCCTGGAGGGTGATGACAATCCCCAACACATGCATTCATGTGGTGCTACTCTGTG TGCAAAGCCAGACCCCAAGTATGTTTTCTCTCTTTGTCCCATCCCTCTTTTTCTGGGACTTTGGACCCTAACTACTTCCCTCCTGAACCT TGCAGTGACATCAGTCCAGGAGAGCTCTCGTTCAGTGTGCGGAAGAACACTCTGACCTCTAGAGCTGTCCTAGATAAGGAGTGGGAGCTT TAGAGGCAAGGCCTCTAGACCCTGGAAGGCTCAGTGAGGCTCTTCCCACAGCATGCTTCTCACTGGTGCCCTGTAAGGCTCGAGCCACCG CTGACTCTGAGCCTTTTGGAGTCTTTCCTCCTTCGTCTCCATTGTTCCCGTGCATTTCCAAAAGCTTAAGTTGCCTGGTGGGCATTTCCC CAGTTTCTTTGGCCTCCGTCTTCTCAAGTCACATAGGGAAAGTACCTCCTGGAACCAGGCTGCAGTATGCAGGACCTGCCAGGCAGGCAC TGGTGAAGGGCCTTGGGCCTATCATCCCCCCAACCCCACCTCACCCCACCCGCCTCCTCTAGTGGGGTGAGTCTGGGCTGGTGGACCAGA GAGGGTGTCACAGACCCTCAGGGACTGCCCCATGGACACCTCTGACTGGTGTTAACAGTGTGAACATTTTCCCCGTCTTCAGTCCCTTAG AATGACGACAGCCCCTGGGGTTGGGGCAGGCGAGTGTGGCCACATCATCCAAGCCCTCCCAGAGACACAAATAGGCTTTTTTGCTCTAAA AATAAATACCAGCCCTTTTTTGGTCACAAATCCAGCATCTCAGCAGAAAACTGCCTGACATGAAAAGTCCCCTGAGGAACTGCATCTGCG TTTCAGGGGCTTTTCATTTTTTCTCCTTTTTTAAAGTGTAGATTGTGGGTGCTTCCTAGAGGCCTGCCTTCTTCTGGAACTGGAAGTGGG CTATCACCATGGGCAAGCCCTTGGGTGCAGGCTCCCCACCTGCCTGGGAACTCTGGCAGCTCTCCTCAGCTCCTTGGGCTTGAGCAGCTG CAACTGCCCCAGATTTGCTGTGGAAGCAGGGGCTAGCCCTGGCCTCACCAGGGCCTCCCGGGGCCCTGCATTGATGCTCAGGAGTTCCTG GGCTGCTCTTGATCCTTTCTGGGCATCCAGCTTCCAGTTAAGCTCTGTTTGCCAAACAAACTATTCTCAGCTGCCCTTTGGCCTGCGCCT GATGTGTTCCTGTTGCAGTCCCGCCTGCCTGAGACAGGAGCAGGCAGGAGAGCCTTCATGCCCAGATTCCCACAGGACAATTGGGGAGCT GCTGGCATTGTCTTTCTGGGAAGATTCTGCTTTCTTGGACCAAATGGCAGCCTGATTACCAGTGTCGGGCCTGCATGCTGCCCCCGACAC ACGCACGCACGCGCACACACGTGTGCACATGGGCCATAGCCACAAGCCAGCTCTCCTCCAGGGTCCTTTCAACCTCGCTGTCCAGGGACC CTGTCCTTCTTGCCCGTGGGGCTTCCATCTGGCAGAGAACGTTCAGGGCTTGTTGAACTTGAAAGCTCATTAGACTTAAGCTGTCACCTG TGCTTGGTGCCCCAGGAACAGCCAGAGAGGACAGTGCCCACTCACTTCTTGTTGGCAGCCTCCTGTGCAGGAAGTGCCAGCCGGGCCTCG ACGCACCAGCTGGCTGTGGGTCCTGAGGAGGGGCGGGAGGCGGCCGCTCAGTGCAGATGGGGACTCCTCTCCTCTGCCCTGACCTTACCC TCCATTACCTCCTTCACTGGAGTGGGGCTGGGGGGTGGGTGGAATCAGTGTTTTAATCGGATTTTTAAAAAACATTTTATTTCTTTGTAC >3365_3365_3_AKAP8-BRD4_AKAP8_chr19_15490524_ENST00000269701_BRD4_chr19_15367984_ENST00000371835_length(amino acids)=297AA_BP=1 MWSPSKRGCWWAASKTWTRATEDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQ EQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEED KCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKM -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for AKAP8-BRD4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | AKAP8 | chr19:15490524 | chr19:15367984 | ENST00000269701 | - | 1 | 14 | 109_201 | 6.333333333333333 | 693.0 | DDX5 |
Hgene | AKAP8 | chr19:15490524 | chr19:15367984 | ENST00000269701 | - | 1 | 14 | 1_210 | 6.333333333333333 | 693.0 | DPY30 |
Hgene | AKAP8 | chr19:15490524 | chr19:15367984 | ENST00000269701 | - | 1 | 14 | 1_195 | 6.333333333333333 | 693.0 | MCM2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for AKAP8-BRD4 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for AKAP8-BRD4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | AKAP8 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Hgene | AKAP8 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Tgene | C0017636 | Glioblastoma | 2 | CTD_human | |
Tgene | C0334588 | Giant Cell Glioblastoma | 2 | CTD_human | |
Tgene | C1621958 | Glioblastoma Multiforme | 2 | CTD_human | |
Tgene | C0002170 | Alopecia | 1 | CTD_human | |
Tgene | C0007102 | Malignant tumor of colon | 1 | CTD_human | |
Tgene | C0009375 | Colonic Neoplasms | 1 | CTD_human | |
Tgene | C0018798 | Congenital Heart Defects | 1 | GENOMICS_ENGLAND | |
Tgene | C0019193 | Hepatitis, Toxic | 1 | CTD_human | |
Tgene | C0020507 | Hyperplasia | 1 | CTD_human | |
Tgene | C0020542 | Pulmonary Hypertension | 1 | CTD_human | |
Tgene | C0025149 | Medulloblastoma | 1 | CTD_human | |
Tgene | C0025958 | Microcephaly | 1 | GENOMICS_ENGLAND | |
Tgene | C0029463 | Osteosarcoma | 1 | CTD_human | |
Tgene | C0033578 | Prostatic Neoplasms | 1 | CTD_human | |
Tgene | C0040136 | Thyroid Neoplasm | 1 | CTD_human | |
Tgene | C0085413 | Polycystic Kidney, Autosomal Dominant | 1 | CTD_human | |
Tgene | C0086873 | Pseudopelade | 1 | CTD_human | |
Tgene | C0151468 | Thyroid Gland Follicular Adenoma | 1 | CTD_human | |
Tgene | C0162311 | Androgenetic Alopecia | 1 | CTD_human | |
Tgene | C0205833 | Medullomyoblastoma | 1 | CTD_human | |
Tgene | C0263477 | Female pattern alopecia (disorder) | 1 | CTD_human | |
Tgene | C0270972 | Cornelia De Lange Syndrome | 1 | CTD_human | |
Tgene | C0278510 | Childhood Medulloblastoma | 1 | CTD_human | |
Tgene | C0278876 | Adult Medulloblastoma | 1 | CTD_human | |
Tgene | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human | |
Tgene | C0549473 | Thyroid carcinoma | 1 | CTD_human | |
Tgene | C0751291 | Desmoplastic Medulloblastoma | 1 | CTD_human | |
Tgene | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human | |
Tgene | C0887850 | Polycystic Kidney, Type 1 Autosomal Dominant Disease | 1 | CTD_human | |
Tgene | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human | |
Tgene | C1275668 | Melanotic medulloblastoma | 1 | CTD_human | |
Tgene | C1707291 | NUT midline carcinoma | 1 | ORPHANET | |
Tgene | C1802395 | Congenital muscular hypertrophy-cerebral syndrome | 1 | CTD_human | |
Tgene | C1853099 | Cornelia de Lange Syndrome 3 | 1 | CTD_human | |
Tgene | C2751306 | Polycystic kidney disease, type 2 | 1 | CTD_human | |
Tgene | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human | |
Tgene | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND | |
Tgene | C4025871 | Abnormality of the face | 1 | GENOMICS_ENGLAND | |
Tgene | C4083212 | Alopecia, Male Pattern | 1 | CTD_human | |
Tgene | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human | |
Tgene | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human | |
Tgene | C4551851 | Cornelia de Lange Syndrome 1 | 1 | CTD_human |