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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:PAK4-EIF3K (FusionGDB2 ID:HG10298TG27335) |
Fusion Gene Summary for PAK4-EIF3K |
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Fusion gene information | Fusion gene name: PAK4-EIF3K | Fusion gene ID: hg10298tg27335 | Hgene | Tgene | Gene symbol | PAK4 | EIF3K | Gene ID | 10298 | 27335 |
Gene name | p21 (RAC1) activated kinase 4 | eukaryotic translation initiation factor 3 subunit K | |
Synonyms | - | ARG134|EIF3-p28|EIF3S12|HSPC029|M9|MSTP001|PLAC-24|PLAC24|PRO1474|PTD001 | |
Cytomap | ('PAK4')('EIF3K') 19q13.2 | 19q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase PAK 4p21 protein (Cdc42/Rac)-activated kinase 4p21(CDKN1A)-activated kinase 4protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs | eukaryotic translation initiation factor 3 subunit KeIF-3 p28eukaryotic translation initiation factor 3, subunit 12muscle specificmuscle-specific gene M9 protein | |
Modification date | 20200313 | 20200322 | |
UniProtAcc | . | Q9UBQ5 | |
Ensembl transtripts involved in fusion gene | ENST00000597766, ENST00000321944, ENST00000358301, ENST00000593690, ENST00000599386, ENST00000599470, ENST00000360442, ENST00000435673, | ||
Fusion gene scores | * DoF score | 16 X 6 X 9=864 | 9 X 11 X 9=891 |
# samples | 20 | 14 | |
** MAII score | log2(20/864*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/891*10)=-2.66999860457696 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PAK4 [Title/Abstract] AND EIF3K [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | PAK4(39616559)-EIF3K(39110976), # samples:1 PAK4(39616559)-EIF3K(39110977), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | EIF3K | GO:0006413 | translational initiation | 17581632 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | Non-Cancer | TCGA-BT-A20W-11A | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
ChimerDB4 | Non-Cancer | TCGA-BT-A20W-11A | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
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Fusion Gene ORF analysis for PAK4-EIF3K |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000597766 | ENST00000593062 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
3UTR-3UTR | ENST00000597766 | ENST00000593062 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
3UTR-5UTR | ENST00000597766 | ENST00000248342 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
3UTR-5UTR | ENST00000597766 | ENST00000248342 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
3UTR-5UTR | ENST00000597766 | ENST00000593149 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
3UTR-5UTR | ENST00000597766 | ENST00000593149 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
3UTR-intron | ENST00000597766 | ENST00000538434 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
3UTR-intron | ENST00000597766 | ENST00000538434 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
3UTR-intron | ENST00000597766 | ENST00000545173 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
3UTR-intron | ENST00000597766 | ENST00000545173 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
3UTR-intron | ENST00000597766 | ENST00000588934 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
3UTR-intron | ENST00000597766 | ENST00000588934 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
3UTR-intron | ENST00000597766 | ENST00000592558 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
3UTR-intron | ENST00000597766 | ENST00000592558 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-3UTR | ENST00000321944 | ENST00000593062 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-3UTR | ENST00000321944 | ENST00000593062 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-3UTR | ENST00000358301 | ENST00000593062 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-3UTR | ENST00000358301 | ENST00000593062 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-3UTR | ENST00000593690 | ENST00000593062 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-3UTR | ENST00000593690 | ENST00000593062 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-3UTR | ENST00000599386 | ENST00000593062 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-3UTR | ENST00000599386 | ENST00000593062 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-3UTR | ENST00000599470 | ENST00000593062 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-3UTR | ENST00000599470 | ENST00000593062 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-5UTR | ENST00000321944 | ENST00000248342 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-5UTR | ENST00000321944 | ENST00000248342 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-5UTR | ENST00000321944 | ENST00000593149 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-5UTR | ENST00000321944 | ENST00000593149 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-5UTR | ENST00000358301 | ENST00000248342 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-5UTR | ENST00000358301 | ENST00000248342 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-5UTR | ENST00000358301 | ENST00000593149 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-5UTR | ENST00000358301 | ENST00000593149 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-5UTR | ENST00000593690 | ENST00000248342 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-5UTR | ENST00000593690 | ENST00000248342 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-5UTR | ENST00000593690 | ENST00000593149 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-5UTR | ENST00000593690 | ENST00000593149 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-5UTR | ENST00000599386 | ENST00000248342 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-5UTR | ENST00000599386 | ENST00000248342 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-5UTR | ENST00000599386 | ENST00000593149 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-5UTR | ENST00000599386 | ENST00000593149 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-5UTR | ENST00000599470 | ENST00000248342 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-5UTR | ENST00000599470 | ENST00000248342 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-5UTR | ENST00000599470 | ENST00000593149 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-5UTR | ENST00000599470 | ENST00000593149 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000321944 | ENST00000538434 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000321944 | ENST00000538434 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000321944 | ENST00000545173 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000321944 | ENST00000545173 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000321944 | ENST00000588934 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000321944 | ENST00000588934 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000321944 | ENST00000592558 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000321944 | ENST00000592558 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000358301 | ENST00000538434 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000358301 | ENST00000538434 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000358301 | ENST00000545173 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000358301 | ENST00000545173 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000358301 | ENST00000588934 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000358301 | ENST00000588934 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000358301 | ENST00000592558 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000358301 | ENST00000592558 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000593690 | ENST00000538434 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000593690 | ENST00000538434 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000593690 | ENST00000545173 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000593690 | ENST00000545173 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000593690 | ENST00000588934 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000593690 | ENST00000588934 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000593690 | ENST00000592558 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000593690 | ENST00000592558 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000599386 | ENST00000538434 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000599386 | ENST00000538434 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000599386 | ENST00000545173 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000599386 | ENST00000545173 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000599386 | ENST00000588934 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000599386 | ENST00000588934 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000599386 | ENST00000592558 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000599386 | ENST00000592558 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000599470 | ENST00000538434 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000599470 | ENST00000538434 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000599470 | ENST00000545173 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000599470 | ENST00000545173 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000599470 | ENST00000588934 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000599470 | ENST00000588934 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
5UTR-intron | ENST00000599470 | ENST00000592558 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
5UTR-intron | ENST00000599470 | ENST00000592558 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
intron-3UTR | ENST00000360442 | ENST00000593062 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
intron-3UTR | ENST00000360442 | ENST00000593062 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
intron-3UTR | ENST00000435673 | ENST00000593062 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
intron-3UTR | ENST00000435673 | ENST00000593062 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
intron-5UTR | ENST00000360442 | ENST00000248342 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
intron-5UTR | ENST00000360442 | ENST00000248342 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
intron-5UTR | ENST00000360442 | ENST00000593149 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
intron-5UTR | ENST00000360442 | ENST00000593149 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
intron-5UTR | ENST00000435673 | ENST00000248342 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
intron-5UTR | ENST00000435673 | ENST00000248342 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
intron-5UTR | ENST00000435673 | ENST00000593149 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
intron-5UTR | ENST00000435673 | ENST00000593149 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
intron-intron | ENST00000360442 | ENST00000538434 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
intron-intron | ENST00000360442 | ENST00000538434 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
intron-intron | ENST00000360442 | ENST00000545173 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
intron-intron | ENST00000360442 | ENST00000545173 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
intron-intron | ENST00000360442 | ENST00000588934 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
intron-intron | ENST00000360442 | ENST00000588934 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
intron-intron | ENST00000360442 | ENST00000592558 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
intron-intron | ENST00000360442 | ENST00000592558 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
intron-intron | ENST00000435673 | ENST00000538434 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
intron-intron | ENST00000435673 | ENST00000538434 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
intron-intron | ENST00000435673 | ENST00000545173 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
intron-intron | ENST00000435673 | ENST00000545173 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
intron-intron | ENST00000435673 | ENST00000588934 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
intron-intron | ENST00000435673 | ENST00000588934 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
intron-intron | ENST00000435673 | ENST00000592558 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + |
intron-intron | ENST00000435673 | ENST00000592558 | PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110977 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for PAK4-EIF3K |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + | 2.72E-07 | 0.99999976 |
PAK4 | chr19 | 39616559 | + | EIF3K | chr19 | 39110976 | + | 2.72E-07 | 0.99999976 |
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Fusion Protein Features for PAK4-EIF3K |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:39616559/:39110976) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | EIF3K |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03010, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for PAK4-EIF3K |
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Fusion Gene PPI Analysis for PAK4-EIF3K |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PAK4-EIF3K |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PAK4-EIF3K |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |