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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ABCA7-ABCA7 (FusionGDB2 ID:HG10347TG10347) |
Fusion Gene Summary for ABCA7-ABCA7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ABCA7-ABCA7 | Fusion gene ID: hg10347tg10347 | Hgene | Tgene | Gene symbol | ABCA7 | ABCA7 | Gene ID | 10347 | 10347 |
| Gene name | ATP binding cassette subfamily A member 7 | ATP binding cassette subfamily A member 7 | |
| Synonyms | ABCA-SSN|ABCX|AD9 | ABCA-SSN|ABCX|AD9 | |
| Cytomap | ('ABCA7')('ABCA7') 19p13.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phospholipid-transporting ATPase ABCA7ATP-binding cassette sub-family A member 7ATP-binding cassette, sub-family A (ABC1), member 7autoantigen SS-Nmacrophage ABC transporter | phospholipid-transporting ATPase ABCA7ATP-binding cassette sub-family A member 7ATP-binding cassette, sub-family A (ABC1), member 7autoantigen SS-Nmacrophage ABC transporter | |
| Modification date | 20200320 | 20200320 | |
| UniProtAcc | Q8IZY2 | Q8IZY2 | |
| Ensembl transtripts involved in fusion gene | ENST00000263094, ENST00000433129, ENST00000435683, ENST00000533574, | ENST00000533574, ENST00000263094, ENST00000433129, ENST00000435683, | |
| Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 5 X 4 X 4=80 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ABCA7 [Title/Abstract] AND ABCA7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ABCA7(1058747)-ABCA7(1058915), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ABCA7-ABCA7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABCA7-ABCA7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABCA7-ABCA7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ABCA7-ABCA7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ABCA7 | GO:0033344 | cholesterol efflux | 14570867 |
| Hgene | ABCA7 | GO:0033700 | phospholipid efflux | 14570867 |
| Hgene | ABCA7 | GO:0034380 | high-density lipoprotein particle assembly | 14570867 |
| Hgene | ABCA7 | GO:0038027 | apolipoprotein A-I-mediated signaling pathway | 14570867 |
| Hgene | ABCA7 | GO:0045332 | phospholipid translocation | 24097981 |
| Tgene | ABCA7 | GO:0033344 | cholesterol efflux | 14570867 |
| Tgene | ABCA7 | GO:0033700 | phospholipid efflux | 14570867 |
| Tgene | ABCA7 | GO:0034380 | high-density lipoprotein particle assembly | 14570867 |
| Tgene | ABCA7 | GO:0038027 | apolipoprotein A-I-mediated signaling pathway | 14570867 |
| Tgene | ABCA7 | GO:0045332 | phospholipid translocation | 24097981 |
| Fusion gene breakpoints across ABCA7 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ABCA7 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for ABCA7-ABCA7 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ABCA7-ABCA7 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for ABCA7-ABCA7 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:1058747/chr19:1058915) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ABCA7 | ABCA7 |
| FUNCTION: Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylserine over phosphatidylcholine (PubMed:24097981). Plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:14592415, PubMed:12917409, PubMed:12925201, PubMed:14570867). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791). {ECO:0000250|UniProtKB:Q91V24, ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:12925201, ECO:0000269|PubMed:14570867, ECO:0000269|PubMed:14592415, ECO:0000269|PubMed:24097981, ECO:0000269|PubMed:26260791}. | FUNCTION: Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylserine over phosphatidylcholine (PubMed:24097981). Plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:14592415, PubMed:12917409, PubMed:12925201, PubMed:14570867). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791). {ECO:0000250|UniProtKB:Q91V24, ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:12925201, ECO:0000269|PubMed:14570867, ECO:0000269|PubMed:14592415, ECO:0000269|PubMed:24097981, ECO:0000269|PubMed:26260791}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 807_1038 | 1759 | 2147.0 | Domain | ABC transporter 1 |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 807_1038 | 1759 | 2147.0 | Domain | ABC transporter 1 |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 807_1038 | 1621 | 2009.0 | Domain | ABC transporter 1 |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 841_848 | 1759 | 2147.0 | Nucleotide binding | ATP 1 |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 841_848 | 1759 | 2147.0 | Nucleotide binding | ATP 1 |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 841_848 | 1621 | 2009.0 | Nucleotide binding | ATP 1 |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 1264_1537 | 1759 | 2147.0 | Topological domain | Extracellular |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 43_549 | 1759 | 2147.0 | Topological domain | Extracellular |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 1264_1537 | 1759 | 2147.0 | Topological domain | Extracellular |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 43_549 | 1759 | 2147.0 | Topological domain | Extracellular |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 1264_1537 | 1621 | 2009.0 | Topological domain | Extracellular |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 43_549 | 1621 | 2009.0 | Topological domain | Extracellular |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 1243_1263 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 1538_1558 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 1584_1604 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 1621_1641 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 1649_1669 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 1683_1703 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 1729_1749 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 22_42 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 550_570 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 593_613 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 626_646 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 655_675 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 687_707 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 727_747 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 849_869 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 1243_1263 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 1538_1558 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 1584_1604 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 1621_1641 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 1649_1669 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 1683_1703 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 1729_1749 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 22_42 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 550_570 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 593_613 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 626_646 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 655_675 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 687_707 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 727_747 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 849_869 | 1759 | 2147.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 1243_1263 | 1621 | 2009.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 1538_1558 | 1621 | 2009.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 1584_1604 | 1621 | 2009.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 22_42 | 1621 | 2009.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 550_570 | 1621 | 2009.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 593_613 | 1621 | 2009.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 626_646 | 1621 | 2009.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 655_675 | 1621 | 2009.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 687_707 | 1621 | 2009.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 727_747 | 1621 | 2009.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 849_869 | 1621 | 2009.0 | Transmembrane | Helical |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 1793_2025 | 0 | 2147.0 | Domain | ABC transporter 2 | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 807_1038 | 0 | 2147.0 | Domain | ABC transporter 1 | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 1793_2025 | 0 | 2147.0 | Domain | ABC transporter 2 | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 807_1038 | 0 | 2147.0 | Domain | ABC transporter 1 | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 1793_2025 | 0 | 2009.0 | Domain | ABC transporter 2 | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 807_1038 | 0 | 2009.0 | Domain | ABC transporter 1 | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 1827_1834 | 0 | 2147.0 | Nucleotide binding | ATP 2 | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 841_848 | 0 | 2147.0 | Nucleotide binding | ATP 1 | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 1827_1834 | 0 | 2147.0 | Nucleotide binding | ATP 2 | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 841_848 | 0 | 2147.0 | Nucleotide binding | ATP 1 | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 1827_1834 | 0 | 2009.0 | Nucleotide binding | ATP 2 | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 841_848 | 0 | 2009.0 | Nucleotide binding | ATP 1 | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 1264_1537 | 0 | 2147.0 | Topological domain | Extracellular | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 43_549 | 0 | 2147.0 | Topological domain | Extracellular | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 1264_1537 | 0 | 2147.0 | Topological domain | Extracellular | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 43_549 | 0 | 2147.0 | Topological domain | Extracellular | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 1264_1537 | 0 | 2009.0 | Topological domain | Extracellular | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 43_549 | 0 | 2009.0 | Topological domain | Extracellular | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 1243_1263 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 1538_1558 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 1584_1604 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 1621_1641 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 1649_1669 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 1683_1703 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 1729_1749 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 22_42 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 550_570 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 593_613 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 626_646 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 655_675 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 687_707 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 727_747 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | 0 | 47 | 849_869 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 1243_1263 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 1538_1558 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 1584_1604 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 1621_1641 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 1649_1669 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 1683_1703 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 1729_1749 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 22_42 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 550_570 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 593_613 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 626_646 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 655_675 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 687_707 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 727_747 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | 0 | 46 | 849_869 | 0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 1243_1263 | 0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 1538_1558 | 0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 1584_1604 | 0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 1621_1641 | 0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 1649_1669 | 0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 1683_1703 | 0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 1729_1749 | 0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 22_42 | 0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 550_570 | 0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 593_613 | 0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 626_646 | 0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 655_675 | 0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 687_707 | 0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 727_747 | 0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | 0 | 41 | 849_869 | 0 | 2009.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 1793_2025 | 1759 | 2147.0 | Domain | ABC transporter 2 |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 1793_2025 | 1759 | 2147.0 | Domain | ABC transporter 2 |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 1793_2025 | 1621 | 2009.0 | Domain | ABC transporter 2 |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000263094 | + | 38 | 47 | 1827_1834 | 1759 | 2147.0 | Nucleotide binding | ATP 2 |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000433129 | + | 37 | 46 | 1827_1834 | 1759 | 2147.0 | Nucleotide binding | ATP 2 |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 1827_1834 | 1621 | 2009.0 | Nucleotide binding | ATP 2 |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 1621_1641 | 1621 | 2009.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 1649_1669 | 1621 | 2009.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 1683_1703 | 1621 | 2009.0 | Transmembrane | Helical |
| Hgene | ABCA7 | chr19:1058747 | chr19:1058915 | ENST00000435683 | + | 32 | 41 | 1729_1749 | 1621 | 2009.0 | Transmembrane | Helical |
Top |
Fusion Gene Sequence for ABCA7-ABCA7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
Top |
Fusion Gene PPI Analysis for ABCA7-ABCA7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for ABCA7-ABCA7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for ABCA7-ABCA7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ABCA7 | C0276496 | Familial Alzheimer Disease (FAD) | 3 | CTD_human;ORPHANET |
| Hgene | ABCA7 | C4282179 | ALZHEIMER DISEASE 9, SUSCEPTIBILITY TO | 3 | UNIPROT |
| Hgene | ABCA7 | C0002395 | Alzheimer's Disease | 2 | CTD_human |
| Hgene | ABCA7 | C0011265 | Presenile dementia | 2 | CTD_human |
| Hgene | ABCA7 | C0494463 | Alzheimer Disease, Late Onset | 2 | CTD_human |
| Hgene | ABCA7 | C0546126 | Acute Confusional Senile Dementia | 2 | CTD_human |
| Hgene | ABCA7 | C0750900 | Alzheimer's Disease, Focal Onset | 2 | CTD_human |
| Hgene | ABCA7 | C0750901 | Alzheimer Disease, Early Onset | 2 | CTD_human |
| Hgene | ABCA7 | C0235874 | Disease Exacerbation | 1 | CTD_human |
| Tgene | C0276496 | Familial Alzheimer Disease (FAD) | 3 | CTD_human;ORPHANET | |
| Tgene | C4282179 | ALZHEIMER DISEASE 9, SUSCEPTIBILITY TO | 3 | UNIPROT | |
| Tgene | C0002395 | Alzheimer's Disease | 2 | CTD_human | |
| Tgene | C0011265 | Presenile dementia | 2 | CTD_human | |
| Tgene | C0494463 | Alzheimer Disease, Late Onset | 2 | CTD_human | |
| Tgene | C0546126 | Acute Confusional Senile Dementia | 2 | CTD_human | |
| Tgene | C0750900 | Alzheimer's Disease, Focal Onset | 2 | CTD_human | |
| Tgene | C0750901 | Alzheimer Disease, Early Onset | 2 | CTD_human | |
| Tgene | C0235874 | Disease Exacerbation | 1 | CTD_human |
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