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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARIH2-CAMP (FusionGDB2 ID:HG10425TG820)

Fusion Gene Summary for ARIH2-CAMP

check button Fusion gene summary
Fusion gene informationFusion gene name: ARIH2-CAMP
Fusion gene ID: hg10425tg820
HgeneTgene
Gene symbol

ARIH2

CAMP

Gene ID

10425

820

Gene nameariadne RBR E3 ubiquitin protein ligase 2cathelicidin antimicrobial peptide
SynonymsARI2|TRIAD1CAP-18|CAP18|CRAMP|FALL-39|FALL39|HSD26|LL37
Cytomap('ARIH2')('CAMP')

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase ARIH2RING-type E3 ubiquitin transferase ARIH2all-trans retinoic acid inducible RING fingerariadne homolog 2protein ariadne-2 homologcathelicidin antimicrobial peptide18 kDa cationic antimicrobial proteinepididymis secretory sperm binding protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000490095, ENST00000356401, 
ENST00000449376, 
Fusion gene scores* DoF score10 X 9 X 7=6302 X 2 X 2=8
# samples 123
** MAII scorelog2(12/630*10)=-2.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/8*10)=1.90689059560852
Context

PubMed: ARIH2 [Title/Abstract] AND CAMP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARIH2(48965246)-CAMP(48265844), # samples:2
Anticipated loss of major functional domain due to fusion event.ARIH2-CAMP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARIH2-CAMP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARIH2

GO:0000209

protein polyubiquitination

16118314|19340006

HgeneARIH2

GO:0006511

ubiquitin-dependent protein catabolic process

16118314

HgeneARIH2

GO:0016567

protein ubiquitination

24076655

HgeneARIH2

GO:0048588

developmental cell growth

19340006

HgeneARIH2

GO:0070534

protein K63-linked ubiquitination

19340006

HgeneARIH2

GO:0070936

protein K48-linked ubiquitination

16118314|19340006

HgeneARIH2

GO:0071425

hematopoietic stem cell proliferation

16118314|19340006

TgeneCAMP

GO:0002227

innate immune response in mucosa

12860195

TgeneCAMP

GO:0019731

antibacterial humoral response

12860195

TgeneCAMP

GO:0050830

defense response to Gram-positive bacterium

12860195

TgeneCAMP

GO:0051873

killing by host of symbiont cells

16020269|16177355

TgeneCAMP

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

12860195


check buttonFusion gene breakpoints across ARIH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CAMP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-14-2554-01AARIH2chr3

48956431

+CAMPchr3

48265844

+
ChimerDB4GBMTCGA-14-2554-01AARIH2chr3

48965246

-CAMPchr3

48265844

+
ChimerDB4GBMTCGA-14-2554-01AARIH2chr3

48965246

+CAMPchr3

48265844

+
ChimerDB4GBMTCGA-14-2554ARIH2chr3

48956431

+CAMPchr3

48265843

+
ChimerDB4GBMTCGA-14-2554ARIH2chr3

48965246

+CAMPchr3

48265843

+


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Fusion Gene ORF analysis for ARIH2-CAMP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000490095ENST00000296435ARIH2chr3

48956431

+CAMPchr3

48265844

+
3UTR-3CDSENST00000490095ENST00000296435ARIH2chr3

48956431

+CAMPchr3

48265843

+
3UTR-3CDSENST00000490095ENST00000576243ARIH2chr3

48956431

+CAMPchr3

48265844

+
3UTR-3CDSENST00000490095ENST00000576243ARIH2chr3

48956431

+CAMPchr3

48265843

+
5UTR-3CDSENST00000356401ENST00000296435ARIH2chr3

48956431

+CAMPchr3

48265844

+
5UTR-3CDSENST00000356401ENST00000296435ARIH2chr3

48956431

+CAMPchr3

48265843

+
5UTR-3CDSENST00000356401ENST00000576243ARIH2chr3

48956431

+CAMPchr3

48265844

+
5UTR-3CDSENST00000356401ENST00000576243ARIH2chr3

48956431

+CAMPchr3

48265843

+
5UTR-3CDSENST00000449376ENST00000296435ARIH2chr3

48956431

+CAMPchr3

48265844

+
5UTR-3CDSENST00000449376ENST00000296435ARIH2chr3

48956431

+CAMPchr3

48265843

+
5UTR-3CDSENST00000449376ENST00000576243ARIH2chr3

48956431

+CAMPchr3

48265844

+
5UTR-3CDSENST00000449376ENST00000576243ARIH2chr3

48956431

+CAMPchr3

48265843

+
In-frameENST00000356401ENST00000296435ARIH2chr3

48965246

+CAMPchr3

48265844

+
In-frameENST00000356401ENST00000296435ARIH2chr3

48965246

+CAMPchr3

48265843

+
In-frameENST00000356401ENST00000576243ARIH2chr3

48965246

+CAMPchr3

48265844

+
In-frameENST00000356401ENST00000576243ARIH2chr3

48965246

+CAMPchr3

48265843

+
In-frameENST00000449376ENST00000296435ARIH2chr3

48965246

+CAMPchr3

48265844

+
In-frameENST00000449376ENST00000296435ARIH2chr3

48965246

+CAMPchr3

48265843

+
In-frameENST00000449376ENST00000576243ARIH2chr3

48965246

+CAMPchr3

48265844

+
In-frameENST00000449376ENST00000576243ARIH2chr3

48965246

+CAMPchr3

48265843

+
intron-3CDSENST00000490095ENST00000296435ARIH2chr3

48965246

+CAMPchr3

48265844

+
intron-3CDSENST00000490095ENST00000296435ARIH2chr3

48965246

+CAMPchr3

48265843

+
intron-3CDSENST00000490095ENST00000576243ARIH2chr3

48965246

+CAMPchr3

48265844

+
intron-3CDSENST00000490095ENST00000576243ARIH2chr3

48965246

+CAMPchr3

48265843

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356401ARIH2chr348965246+ENST00000296435CAMPchr348265843+973594327905192
ENST00000356401ARIH2chr348965246+ENST00000576243CAMPchr348265843+967594327905192
ENST00000449376ARIH2chr348965246+ENST00000296435CAMPchr348265843+10807014341012192
ENST00000449376ARIH2chr348965246+ENST00000576243CAMPchr348265843+10747014341012192
ENST00000356401ARIH2chr348965246+ENST00000296435CAMPchr348265844+973594327905192
ENST00000356401ARIH2chr348965246+ENST00000576243CAMPchr348265844+967594327905192
ENST00000449376ARIH2chr348965246+ENST00000296435CAMPchr348265844+10807014341012192
ENST00000449376ARIH2chr348965246+ENST00000576243CAMPchr348265844+10747014341012192

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356401ENST00000296435ARIH2chr348965246+CAMPchr348265843+0.0017711910.99822885
ENST00000356401ENST00000576243ARIH2chr348965246+CAMPchr348265843+0.0018391170.9981609
ENST00000449376ENST00000296435ARIH2chr348965246+CAMPchr348265843+0.0016589140.9983411
ENST00000449376ENST00000576243ARIH2chr348965246+CAMPchr348265843+0.0017221930.9982778
ENST00000356401ENST00000296435ARIH2chr348965246+CAMPchr348265844+0.0017711910.99822885
ENST00000356401ENST00000576243ARIH2chr348965246+CAMPchr348265844+0.0018391170.9981609
ENST00000449376ENST00000296435ARIH2chr348965246+CAMPchr348265844+0.0016589140.9983411
ENST00000449376ENST00000576243ARIH2chr348965246+CAMPchr348265844+0.0017221930.9982778

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Fusion Genomic Features for ARIH2-CAMP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARIH2chr348965246+CAMPchr348265843+1.42E-091
ARIH2chr348956431+CAMPchr348265843+6.02E-091
ARIH2chr348965246+CAMPchr348265843+1.42E-091
ARIH2chr348956431+CAMPchr348265843+6.02E-091
ARIH2chr348965246+CAMPchr348265843+1.42E-091
ARIH2chr348956431+CAMPchr348265843+6.02E-091
ARIH2chr348965246+CAMPchr348265843+1.42E-091
ARIH2chr348956431+CAMPchr348265843+6.02E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARIH2-CAMP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:48965246/chr3:48265844)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARIH2chr3:48965246chr3:48265843ENST00000356401+316135_34485494.0RegionTRIAD supradomain
HgeneARIH2chr3:48965246chr3:48265843ENST00000356401+316359_49385494.0RegionAriadne domain
HgeneARIH2chr3:48965246chr3:48265843ENST00000356401+31665_11285494.0RegionUBA-like
HgeneARIH2chr3:48965246chr3:48265843ENST00000449376+417135_34485494.0RegionTRIAD supradomain
HgeneARIH2chr3:48965246chr3:48265843ENST00000449376+417359_49385494.0RegionAriadne domain
HgeneARIH2chr3:48965246chr3:48265843ENST00000449376+41765_11285494.0RegionUBA-like
HgeneARIH2chr3:48965246chr3:48265844ENST00000356401+316135_34485494.0RegionTRIAD supradomain
HgeneARIH2chr3:48965246chr3:48265844ENST00000356401+316359_49385494.0RegionAriadne domain
HgeneARIH2chr3:48965246chr3:48265844ENST00000356401+31665_11285494.0RegionUBA-like
HgeneARIH2chr3:48965246chr3:48265844ENST00000449376+417135_34485494.0RegionTRIAD supradomain
HgeneARIH2chr3:48965246chr3:48265844ENST00000449376+417359_49385494.0RegionAriadne domain
HgeneARIH2chr3:48965246chr3:48265844ENST00000449376+41765_11285494.0RegionUBA-like
HgeneARIH2chr3:48965246chr3:48265843ENST00000356401+316139_18885494.0Zinc fingerRING-type 1
HgeneARIH2chr3:48965246chr3:48265843ENST00000356401+316208_27085494.0Zinc fingerIBR-type
HgeneARIH2chr3:48965246chr3:48265843ENST00000356401+316297_32685494.0Zinc fingerRING-type 2%3B atypical
HgeneARIH2chr3:48965246chr3:48265843ENST00000449376+417139_18885494.0Zinc fingerRING-type 1
HgeneARIH2chr3:48965246chr3:48265843ENST00000449376+417208_27085494.0Zinc fingerIBR-type
HgeneARIH2chr3:48965246chr3:48265843ENST00000449376+417297_32685494.0Zinc fingerRING-type 2%3B atypical
HgeneARIH2chr3:48965246chr3:48265844ENST00000356401+316139_18885494.0Zinc fingerRING-type 1
HgeneARIH2chr3:48965246chr3:48265844ENST00000356401+316208_27085494.0Zinc fingerIBR-type
HgeneARIH2chr3:48965246chr3:48265844ENST00000356401+316297_32685494.0Zinc fingerRING-type 2%3B atypical
HgeneARIH2chr3:48965246chr3:48265844ENST00000449376+417139_18885494.0Zinc fingerRING-type 1
HgeneARIH2chr3:48965246chr3:48265844ENST00000449376+417208_27085494.0Zinc fingerIBR-type
HgeneARIH2chr3:48965246chr3:48265844ENST00000449376+417297_32685494.0Zinc fingerRING-type 2%3B atypical


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Fusion Gene Sequence for ARIH2-CAMP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6529_6529_1_ARIH2-CAMP_ARIH2_chr3_48965246_ENST00000356401_CAMP_chr3_48265843_ENST00000296435_length(transcript)=973nt_BP=594nt
GCAACGGCGCCAAGCACTTCCGGAGCTGTGGGGACGACTCTTCTGGAGGAAGCAGCGCGGGCTTGACCGGCGTCGGCCCGCCGCCTCCGC
TGCCGCTTCGCCCCAATCCGGTCCCTCTGGCCCGGCCTGACCCGGTCTGGCTTGTTCGGGCTCAGCGGCCGCGAGGCCGCAGCTCCCGAT
GGAAATCATATTATGTAGAATACTTGGGTGACATCTGCCTGAGAGATCTCCAAGAATTACAGAAGACAAAAATACTAATGCATTTGAGAA
AGCGGTAGTTTTGGGGGGAGGGGGAAAAAGCAACTGCTTTCCTGATCTGCAACTTGGCTGGATGCTAAGATGTCAGTGGACATGAATAGC
CAGGGGTCTGACAGCAATGAAGAGGACTATGACCCAAATTGTGAGGAAGAGGAAGAAGAAGAAGAAGACGACCCTGGGGACATAGAGGAC
TATTACGTGGGAGTAGCCAGCGATGTGGAGCAGCAGGGGGCTGATGCCTTTGATCCCGAGGAGTACCAGTTCACTTGCTTGACCTACAAG
GAATCTGAGGGTGCCCTCAATGAGCACATGACCAGCTTAGCTTCTGTCCTAAAGGATGGGGACCCAGACACGCCAAAGCCTGTGAGCTTC
ACAGTGAAGGAGACAGTGTGCCCCAGGACGACACAGCAGTCACCAGAGGATTGTGACTTCAAGAAGGACGGGCTGGTGAAGCGGTGTATG
GGGACAGTGACCCTCAACCAGGCCAGGGGCTCCTTTGACATCAGTTGTGATAAGGATAACAAGAGATTTGCCCTGCTGGGTGATTTCTTC
CGGAAATCTAAAGAGAAGATTGGCAAAGAGTTTAAAAGAATTGTCCAGAGAATCAAGGATTTTTTGCGGAATCTTGTACCCAGGACAGAG
TCCTAGTGTGTGCCCTACCCTGGCTCAGGCTTCTGGGCTCTGAGAAATAAACTATGAGAGCAATTTCCTCAGG

>6529_6529_1_ARIH2-CAMP_ARIH2_chr3_48965246_ENST00000356401_CAMP_chr3_48265843_ENST00000296435_length(amino acids)=192AA_BP=89
MDAKMSVDMNSQGSDSNEEDYDPNCEEEEEEEEDDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALNEHMTSLASVLKD
GDPDTPKPVSFTVKETVCPRTTQQSPEDCDFKKDGLVKRCMGTVTLNQARGSFDISCDKDNKRFALLGDFFRKSKEKIGKEFKRIVQRIK
DFLRNLVPRTES

--------------------------------------------------------------
>6529_6529_2_ARIH2-CAMP_ARIH2_chr3_48965246_ENST00000356401_CAMP_chr3_48265843_ENST00000576243_length(transcript)=967nt_BP=594nt
GCAACGGCGCCAAGCACTTCCGGAGCTGTGGGGACGACTCTTCTGGAGGAAGCAGCGCGGGCTTGACCGGCGTCGGCCCGCCGCCTCCGC
TGCCGCTTCGCCCCAATCCGGTCCCTCTGGCCCGGCCTGACCCGGTCTGGCTTGTTCGGGCTCAGCGGCCGCGAGGCCGCAGCTCCCGAT
GGAAATCATATTATGTAGAATACTTGGGTGACATCTGCCTGAGAGATCTCCAAGAATTACAGAAGACAAAAATACTAATGCATTTGAGAA
AGCGGTAGTTTTGGGGGGAGGGGGAAAAAGCAACTGCTTTCCTGATCTGCAACTTGGCTGGATGCTAAGATGTCAGTGGACATGAATAGC
CAGGGGTCTGACAGCAATGAAGAGGACTATGACCCAAATTGTGAGGAAGAGGAAGAAGAAGAAGAAGACGACCCTGGGGACATAGAGGAC
TATTACGTGGGAGTAGCCAGCGATGTGGAGCAGCAGGGGGCTGATGCCTTTGATCCCGAGGAGTACCAGTTCACTTGCTTGACCTACAAG
GAATCTGAGGGTGCCCTCAATGAGCACATGACCAGCTTAGCTTCTGTCCTAAAGGATGGGGACCCAGACACGCCAAAGCCTGTGAGCTTC
ACAGTGAAGGAGACAGTGTGCCCCAGGACGACACAGCAGTCACCAGAGGATTGTGACTTCAAGAAGGACGGGCTGGTGAAGCGGTGTATG
GGGACAGTGACCCTCAACCAGGCCAGGGGCTCCTTTGACATCAGTTGTGATAAGGATAACAAGAGATTTGCCCTGCTGGGTGATTTCTTC
CGGAAATCTAAAGAGAAGATTGGCAAAGAGTTTAAAAGAATTGTCCAGAGAATCAAGGATTTTTTGCGGAATCTTGTACCCAGGACAGAG
TCCTAGTGTGTGCCCTACCCTGGCTCAGGCTTCTGGGCTCTGAGAAATAAACTATGAGAGCAATTTC

>6529_6529_2_ARIH2-CAMP_ARIH2_chr3_48965246_ENST00000356401_CAMP_chr3_48265843_ENST00000576243_length(amino acids)=192AA_BP=89
MDAKMSVDMNSQGSDSNEEDYDPNCEEEEEEEEDDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALNEHMTSLASVLKD
GDPDTPKPVSFTVKETVCPRTTQQSPEDCDFKKDGLVKRCMGTVTLNQARGSFDISCDKDNKRFALLGDFFRKSKEKIGKEFKRIVQRIK
DFLRNLVPRTES

--------------------------------------------------------------
>6529_6529_3_ARIH2-CAMP_ARIH2_chr3_48965246_ENST00000356401_CAMP_chr3_48265844_ENST00000296435_length(transcript)=973nt_BP=594nt
GCAACGGCGCCAAGCACTTCCGGAGCTGTGGGGACGACTCTTCTGGAGGAAGCAGCGCGGGCTTGACCGGCGTCGGCCCGCCGCCTCCGC
TGCCGCTTCGCCCCAATCCGGTCCCTCTGGCCCGGCCTGACCCGGTCTGGCTTGTTCGGGCTCAGCGGCCGCGAGGCCGCAGCTCCCGAT
GGAAATCATATTATGTAGAATACTTGGGTGACATCTGCCTGAGAGATCTCCAAGAATTACAGAAGACAAAAATACTAATGCATTTGAGAA
AGCGGTAGTTTTGGGGGGAGGGGGAAAAAGCAACTGCTTTCCTGATCTGCAACTTGGCTGGATGCTAAGATGTCAGTGGACATGAATAGC
CAGGGGTCTGACAGCAATGAAGAGGACTATGACCCAAATTGTGAGGAAGAGGAAGAAGAAGAAGAAGACGACCCTGGGGACATAGAGGAC
TATTACGTGGGAGTAGCCAGCGATGTGGAGCAGCAGGGGGCTGATGCCTTTGATCCCGAGGAGTACCAGTTCACTTGCTTGACCTACAAG
GAATCTGAGGGTGCCCTCAATGAGCACATGACCAGCTTAGCTTCTGTCCTAAAGGATGGGGACCCAGACACGCCAAAGCCTGTGAGCTTC
ACAGTGAAGGAGACAGTGTGCCCCAGGACGACACAGCAGTCACCAGAGGATTGTGACTTCAAGAAGGACGGGCTGGTGAAGCGGTGTATG
GGGACAGTGACCCTCAACCAGGCCAGGGGCTCCTTTGACATCAGTTGTGATAAGGATAACAAGAGATTTGCCCTGCTGGGTGATTTCTTC
CGGAAATCTAAAGAGAAGATTGGCAAAGAGTTTAAAAGAATTGTCCAGAGAATCAAGGATTTTTTGCGGAATCTTGTACCCAGGACAGAG
TCCTAGTGTGTGCCCTACCCTGGCTCAGGCTTCTGGGCTCTGAGAAATAAACTATGAGAGCAATTTCCTCAGG

>6529_6529_3_ARIH2-CAMP_ARIH2_chr3_48965246_ENST00000356401_CAMP_chr3_48265844_ENST00000296435_length(amino acids)=192AA_BP=89
MDAKMSVDMNSQGSDSNEEDYDPNCEEEEEEEEDDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALNEHMTSLASVLKD
GDPDTPKPVSFTVKETVCPRTTQQSPEDCDFKKDGLVKRCMGTVTLNQARGSFDISCDKDNKRFALLGDFFRKSKEKIGKEFKRIVQRIK
DFLRNLVPRTES

--------------------------------------------------------------
>6529_6529_4_ARIH2-CAMP_ARIH2_chr3_48965246_ENST00000356401_CAMP_chr3_48265844_ENST00000576243_length(transcript)=967nt_BP=594nt
GCAACGGCGCCAAGCACTTCCGGAGCTGTGGGGACGACTCTTCTGGAGGAAGCAGCGCGGGCTTGACCGGCGTCGGCCCGCCGCCTCCGC
TGCCGCTTCGCCCCAATCCGGTCCCTCTGGCCCGGCCTGACCCGGTCTGGCTTGTTCGGGCTCAGCGGCCGCGAGGCCGCAGCTCCCGAT
GGAAATCATATTATGTAGAATACTTGGGTGACATCTGCCTGAGAGATCTCCAAGAATTACAGAAGACAAAAATACTAATGCATTTGAGAA
AGCGGTAGTTTTGGGGGGAGGGGGAAAAAGCAACTGCTTTCCTGATCTGCAACTTGGCTGGATGCTAAGATGTCAGTGGACATGAATAGC
CAGGGGTCTGACAGCAATGAAGAGGACTATGACCCAAATTGTGAGGAAGAGGAAGAAGAAGAAGAAGACGACCCTGGGGACATAGAGGAC
TATTACGTGGGAGTAGCCAGCGATGTGGAGCAGCAGGGGGCTGATGCCTTTGATCCCGAGGAGTACCAGTTCACTTGCTTGACCTACAAG
GAATCTGAGGGTGCCCTCAATGAGCACATGACCAGCTTAGCTTCTGTCCTAAAGGATGGGGACCCAGACACGCCAAAGCCTGTGAGCTTC
ACAGTGAAGGAGACAGTGTGCCCCAGGACGACACAGCAGTCACCAGAGGATTGTGACTTCAAGAAGGACGGGCTGGTGAAGCGGTGTATG
GGGACAGTGACCCTCAACCAGGCCAGGGGCTCCTTTGACATCAGTTGTGATAAGGATAACAAGAGATTTGCCCTGCTGGGTGATTTCTTC
CGGAAATCTAAAGAGAAGATTGGCAAAGAGTTTAAAAGAATTGTCCAGAGAATCAAGGATTTTTTGCGGAATCTTGTACCCAGGACAGAG
TCCTAGTGTGTGCCCTACCCTGGCTCAGGCTTCTGGGCTCTGAGAAATAAACTATGAGAGCAATTTC

>6529_6529_4_ARIH2-CAMP_ARIH2_chr3_48965246_ENST00000356401_CAMP_chr3_48265844_ENST00000576243_length(amino acids)=192AA_BP=89
MDAKMSVDMNSQGSDSNEEDYDPNCEEEEEEEEDDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALNEHMTSLASVLKD
GDPDTPKPVSFTVKETVCPRTTQQSPEDCDFKKDGLVKRCMGTVTLNQARGSFDISCDKDNKRFALLGDFFRKSKEKIGKEFKRIVQRIK
DFLRNLVPRTES

--------------------------------------------------------------
>6529_6529_5_ARIH2-CAMP_ARIH2_chr3_48965246_ENST00000449376_CAMP_chr3_48265843_ENST00000296435_length(transcript)=1080nt_BP=701nt
ACTTCCGGAGCTGTGGGGACGACTCTTCTGGAGGAAGCAGCGCGGGCTTGACCGGCGTCGGCCCGCCGCCTCCGCTGCCGCTTCGCCCCA
ATCCGGTCCCTCTGGCCCGGCCTGACCCGGTCTGGCTTGTTCGGGCTCAGCGGCCGCGAGGCCGCAGCTCCCGATGGAAATCATATTATG
TAGAATACTTGGGTGACATCTGCCTGAGAGATCTCCAAGAATTACAGATTGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCA
ATCTCTGCTCACTGCAACCTCCGTCTCCCGAGTTCAAGCAGTTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGAAGACAAAAAT
ACTAATGCATTTGAGAAAGCGGTAGTTTTGGGGGGAGGGGGAAAAAGCAACTGCTTTCCTGATCTGCAACTTGGCTGGATGCTAAGATGT
CAGTGGACATGAATAGCCAGGGGTCTGACAGCAATGAAGAGGACTATGACCCAAATTGTGAGGAAGAGGAAGAAGAAGAAGAAGACGACC
CTGGGGACATAGAGGACTATTACGTGGGAGTAGCCAGCGATGTGGAGCAGCAGGGGGCTGATGCCTTTGATCCCGAGGAGTACCAGTTCA
CTTGCTTGACCTACAAGGAATCTGAGGGTGCCCTCAATGAGCACATGACCAGCTTAGCTTCTGTCCTAAAGGATGGGGACCCAGACACGC
CAAAGCCTGTGAGCTTCACAGTGAAGGAGACAGTGTGCCCCAGGACGACACAGCAGTCACCAGAGGATTGTGACTTCAAGAAGGACGGGC
TGGTGAAGCGGTGTATGGGGACAGTGACCCTCAACCAGGCCAGGGGCTCCTTTGACATCAGTTGTGATAAGGATAACAAGAGATTTGCCC
TGCTGGGTGATTTCTTCCGGAAATCTAAAGAGAAGATTGGCAAAGAGTTTAAAAGAATTGTCCAGAGAATCAAGGATTTTTTGCGGAATC
TTGTACCCAGGACAGAGTCCTAGTGTGTGCCCTACCCTGGCTCAGGCTTCTGGGCTCTGAGAAATAAACTATGAGAGCAATTTCCTCAGG


>6529_6529_5_ARIH2-CAMP_ARIH2_chr3_48965246_ENST00000449376_CAMP_chr3_48265843_ENST00000296435_length(amino acids)=192AA_BP=89
MDAKMSVDMNSQGSDSNEEDYDPNCEEEEEEEEDDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALNEHMTSLASVLKD
GDPDTPKPVSFTVKETVCPRTTQQSPEDCDFKKDGLVKRCMGTVTLNQARGSFDISCDKDNKRFALLGDFFRKSKEKIGKEFKRIVQRIK
DFLRNLVPRTES

--------------------------------------------------------------
>6529_6529_6_ARIH2-CAMP_ARIH2_chr3_48965246_ENST00000449376_CAMP_chr3_48265843_ENST00000576243_length(transcript)=1074nt_BP=701nt
ACTTCCGGAGCTGTGGGGACGACTCTTCTGGAGGAAGCAGCGCGGGCTTGACCGGCGTCGGCCCGCCGCCTCCGCTGCCGCTTCGCCCCA
ATCCGGTCCCTCTGGCCCGGCCTGACCCGGTCTGGCTTGTTCGGGCTCAGCGGCCGCGAGGCCGCAGCTCCCGATGGAAATCATATTATG
TAGAATACTTGGGTGACATCTGCCTGAGAGATCTCCAAGAATTACAGATTGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCA
ATCTCTGCTCACTGCAACCTCCGTCTCCCGAGTTCAAGCAGTTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGAAGACAAAAAT
ACTAATGCATTTGAGAAAGCGGTAGTTTTGGGGGGAGGGGGAAAAAGCAACTGCTTTCCTGATCTGCAACTTGGCTGGATGCTAAGATGT
CAGTGGACATGAATAGCCAGGGGTCTGACAGCAATGAAGAGGACTATGACCCAAATTGTGAGGAAGAGGAAGAAGAAGAAGAAGACGACC
CTGGGGACATAGAGGACTATTACGTGGGAGTAGCCAGCGATGTGGAGCAGCAGGGGGCTGATGCCTTTGATCCCGAGGAGTACCAGTTCA
CTTGCTTGACCTACAAGGAATCTGAGGGTGCCCTCAATGAGCACATGACCAGCTTAGCTTCTGTCCTAAAGGATGGGGACCCAGACACGC
CAAAGCCTGTGAGCTTCACAGTGAAGGAGACAGTGTGCCCCAGGACGACACAGCAGTCACCAGAGGATTGTGACTTCAAGAAGGACGGGC
TGGTGAAGCGGTGTATGGGGACAGTGACCCTCAACCAGGCCAGGGGCTCCTTTGACATCAGTTGTGATAAGGATAACAAGAGATTTGCCC
TGCTGGGTGATTTCTTCCGGAAATCTAAAGAGAAGATTGGCAAAGAGTTTAAAAGAATTGTCCAGAGAATCAAGGATTTTTTGCGGAATC
TTGTACCCAGGACAGAGTCCTAGTGTGTGCCCTACCCTGGCTCAGGCTTCTGGGCTCTGAGAAATAAACTATGAGAGCAATTTC

>6529_6529_6_ARIH2-CAMP_ARIH2_chr3_48965246_ENST00000449376_CAMP_chr3_48265843_ENST00000576243_length(amino acids)=192AA_BP=89
MDAKMSVDMNSQGSDSNEEDYDPNCEEEEEEEEDDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALNEHMTSLASVLKD
GDPDTPKPVSFTVKETVCPRTTQQSPEDCDFKKDGLVKRCMGTVTLNQARGSFDISCDKDNKRFALLGDFFRKSKEKIGKEFKRIVQRIK
DFLRNLVPRTES

--------------------------------------------------------------
>6529_6529_7_ARIH2-CAMP_ARIH2_chr3_48965246_ENST00000449376_CAMP_chr3_48265844_ENST00000296435_length(transcript)=1080nt_BP=701nt
ACTTCCGGAGCTGTGGGGACGACTCTTCTGGAGGAAGCAGCGCGGGCTTGACCGGCGTCGGCCCGCCGCCTCCGCTGCCGCTTCGCCCCA
ATCCGGTCCCTCTGGCCCGGCCTGACCCGGTCTGGCTTGTTCGGGCTCAGCGGCCGCGAGGCCGCAGCTCCCGATGGAAATCATATTATG
TAGAATACTTGGGTGACATCTGCCTGAGAGATCTCCAAGAATTACAGATTGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCA
ATCTCTGCTCACTGCAACCTCCGTCTCCCGAGTTCAAGCAGTTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGAAGACAAAAAT
ACTAATGCATTTGAGAAAGCGGTAGTTTTGGGGGGAGGGGGAAAAAGCAACTGCTTTCCTGATCTGCAACTTGGCTGGATGCTAAGATGT
CAGTGGACATGAATAGCCAGGGGTCTGACAGCAATGAAGAGGACTATGACCCAAATTGTGAGGAAGAGGAAGAAGAAGAAGAAGACGACC
CTGGGGACATAGAGGACTATTACGTGGGAGTAGCCAGCGATGTGGAGCAGCAGGGGGCTGATGCCTTTGATCCCGAGGAGTACCAGTTCA
CTTGCTTGACCTACAAGGAATCTGAGGGTGCCCTCAATGAGCACATGACCAGCTTAGCTTCTGTCCTAAAGGATGGGGACCCAGACACGC
CAAAGCCTGTGAGCTTCACAGTGAAGGAGACAGTGTGCCCCAGGACGACACAGCAGTCACCAGAGGATTGTGACTTCAAGAAGGACGGGC
TGGTGAAGCGGTGTATGGGGACAGTGACCCTCAACCAGGCCAGGGGCTCCTTTGACATCAGTTGTGATAAGGATAACAAGAGATTTGCCC
TGCTGGGTGATTTCTTCCGGAAATCTAAAGAGAAGATTGGCAAAGAGTTTAAAAGAATTGTCCAGAGAATCAAGGATTTTTTGCGGAATC
TTGTACCCAGGACAGAGTCCTAGTGTGTGCCCTACCCTGGCTCAGGCTTCTGGGCTCTGAGAAATAAACTATGAGAGCAATTTCCTCAGG


>6529_6529_7_ARIH2-CAMP_ARIH2_chr3_48965246_ENST00000449376_CAMP_chr3_48265844_ENST00000296435_length(amino acids)=192AA_BP=89
MDAKMSVDMNSQGSDSNEEDYDPNCEEEEEEEEDDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALNEHMTSLASVLKD
GDPDTPKPVSFTVKETVCPRTTQQSPEDCDFKKDGLVKRCMGTVTLNQARGSFDISCDKDNKRFALLGDFFRKSKEKIGKEFKRIVQRIK
DFLRNLVPRTES

--------------------------------------------------------------
>6529_6529_8_ARIH2-CAMP_ARIH2_chr3_48965246_ENST00000449376_CAMP_chr3_48265844_ENST00000576243_length(transcript)=1074nt_BP=701nt
ACTTCCGGAGCTGTGGGGACGACTCTTCTGGAGGAAGCAGCGCGGGCTTGACCGGCGTCGGCCCGCCGCCTCCGCTGCCGCTTCGCCCCA
ATCCGGTCCCTCTGGCCCGGCCTGACCCGGTCTGGCTTGTTCGGGCTCAGCGGCCGCGAGGCCGCAGCTCCCGATGGAAATCATATTATG
TAGAATACTTGGGTGACATCTGCCTGAGAGATCTCCAAGAATTACAGATTGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCA
ATCTCTGCTCACTGCAACCTCCGTCTCCCGAGTTCAAGCAGTTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGAAGACAAAAAT
ACTAATGCATTTGAGAAAGCGGTAGTTTTGGGGGGAGGGGGAAAAAGCAACTGCTTTCCTGATCTGCAACTTGGCTGGATGCTAAGATGT
CAGTGGACATGAATAGCCAGGGGTCTGACAGCAATGAAGAGGACTATGACCCAAATTGTGAGGAAGAGGAAGAAGAAGAAGAAGACGACC
CTGGGGACATAGAGGACTATTACGTGGGAGTAGCCAGCGATGTGGAGCAGCAGGGGGCTGATGCCTTTGATCCCGAGGAGTACCAGTTCA
CTTGCTTGACCTACAAGGAATCTGAGGGTGCCCTCAATGAGCACATGACCAGCTTAGCTTCTGTCCTAAAGGATGGGGACCCAGACACGC
CAAAGCCTGTGAGCTTCACAGTGAAGGAGACAGTGTGCCCCAGGACGACACAGCAGTCACCAGAGGATTGTGACTTCAAGAAGGACGGGC
TGGTGAAGCGGTGTATGGGGACAGTGACCCTCAACCAGGCCAGGGGCTCCTTTGACATCAGTTGTGATAAGGATAACAAGAGATTTGCCC
TGCTGGGTGATTTCTTCCGGAAATCTAAAGAGAAGATTGGCAAAGAGTTTAAAAGAATTGTCCAGAGAATCAAGGATTTTTTGCGGAATC
TTGTACCCAGGACAGAGTCCTAGTGTGTGCCCTACCCTGGCTCAGGCTTCTGGGCTCTGAGAAATAAACTATGAGAGCAATTTC

>6529_6529_8_ARIH2-CAMP_ARIH2_chr3_48965246_ENST00000449376_CAMP_chr3_48265844_ENST00000576243_length(amino acids)=192AA_BP=89
MDAKMSVDMNSQGSDSNEEDYDPNCEEEEEEEEDDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALNEHMTSLASVLKD
GDPDTPKPVSFTVKETVCPRTTQQSPEDCDFKKDGLVKRCMGTVTLNQARGSFDISCDKDNKRFALLGDFFRKSKEKIGKEFKRIVQRIK
DFLRNLVPRTES

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARIH2-CAMP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARIH2-CAMP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARIH2-CAMP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource