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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BAIAP2-RPTOR (FusionGDB2 ID:HG10458TG57521)

Fusion Gene Summary for BAIAP2-RPTOR

check button Fusion gene summary
Fusion gene informationFusion gene name: BAIAP2-RPTOR
Fusion gene ID: hg10458tg57521
HgeneTgene
Gene symbol

BAIAP2

RPTOR

Gene ID

10458

57521

Gene nameBAR/IMD domain containing adaptor protein 2regulatory associated protein of MTOR complex 1
SynonymsBAP2|FLAF3|IRSP53|WAMLKOG1|Mip1
Cytomap('BAIAP2')('RPTOR')

17q25.3

17q25.3

Type of geneprotein-codingprotein-coding
Descriptionbrain-specific angiogenesis inhibitor 1-associated protein 2BAI1 associated protein 2IRS-58IRSp53/58WASP and MIM likefas ligand-associated factor 3insulin receptor substrate of 53 kDainsulin receptor substrate p53/p58insulin receptor substrate proregulatory-associated protein of mTORp150 target of rapamycin (TOR)-scaffold protein containing WD-repeatsraptor
Modification date2020032720200313
UniProtAcc

Q9UQB8

.
Ensembl transtripts involved in fusion geneENST00000573894, ENST00000321280, 
ENST00000321300, ENST00000392411, 
ENST00000416299, ENST00000428708, 
ENST00000435091, ENST00000575245, 
ENST00000575712, 		ENST00000573894, 
ENST00000321280, ENST00000321300, 
ENST00000392411, ENST00000416299, 
ENST00000428708, ENST00000435091, 
ENST00000575245, ENST00000575712, 
Fusion gene scores* DoF score6 X 6 X 7=25220 X 22 X 12=5280
# samples 1025
** MAII scorelog2(10/252*10)=-1.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/5280*10)=-4.40053792958373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BAIAP2 [Title/Abstract] AND RPTOR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBAIAP2(79079946)-RPTOR(78914295), # samples:1
BAIAP2(79031767)-RPTOR(78882610), # samples:1
BAIAP2(79060380)-RPTOR(78914296), # samples:1
BAIAP2(79031767)-RPTOR(78882611), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRPTOR

GO:0031929

TOR signaling

20381137

TgeneRPTOR

GO:0032008

positive regulation of TOR signaling

12150926|18439900

TgeneRPTOR

GO:0071233

cellular response to leucine

22424946

TgeneRPTOR

GO:0071902

positive regulation of protein serine/threonine kinase activity

12150926



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-23-1123BAIAP2chr17

79079946

+RPTORchr17

78914295

+
ChimerDB4SKCMTCGA-FS-A1ZQ-06ABAIAP2chr17

79060380

+RPTORchr17

78914296

+
ChimerDB4STADTCGA-D7-A4YY-01ABAIAP2chr17

79031767

+RPTORchr17

78882611

+
ChimerDB4STADTCGA-D7-A4YYBAIAP2chr17

79031767

+RPTORchr17

78882610

+


Top

Fusion Gene ORF analysis for BAIAP2-RPTOR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000573894ENST00000575542BAIAP2chr17

79060380

+RPTORchr17

78914296

+
3UTR-3UTRENST00000573894ENST00000575542BAIAP2chr17

79031767

+RPTORchr17

78882611

+
3UTR-3UTRENST00000573894ENST00000575542BAIAP2chr17

79031767

+RPTORchr17

78882610

+
3UTR-intronENST00000573894ENST00000306801BAIAP2chr17

79060380

+RPTORchr17

78914296

+
3UTR-intronENST00000573894ENST00000306801BAIAP2chr17

79031767

+RPTORchr17

78882611

+
3UTR-intronENST00000573894ENST00000306801BAIAP2chr17

79031767

+RPTORchr17

78882610

+
3UTR-intronENST00000573894ENST00000537330BAIAP2chr17

79060380

+RPTORchr17

78914296

+
3UTR-intronENST00000573894ENST00000537330BAIAP2chr17

79031767

+RPTORchr17

78882611

+
3UTR-intronENST00000573894ENST00000537330BAIAP2chr17

79031767

+RPTORchr17

78882610

+
3UTR-intronENST00000573894ENST00000544334BAIAP2chr17

79060380

+RPTORchr17

78914296

+
3UTR-intronENST00000573894ENST00000544334BAIAP2chr17

79031767

+RPTORchr17

78882611

+
3UTR-intronENST00000573894ENST00000544334BAIAP2chr17

79031767

+RPTORchr17

78882610

+
3UTR-intronENST00000573894ENST00000570891BAIAP2chr17

79060380

+RPTORchr17

78914296

+
3UTR-intronENST00000573894ENST00000570891BAIAP2chr17

79031767

+RPTORchr17

78882611

+
3UTR-intronENST00000573894ENST00000570891BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-3UTRENST00000321280ENST00000575542BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-3UTRENST00000321280ENST00000575542BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-3UTRENST00000321280ENST00000575542BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-3UTRENST00000321280ENST00000575542BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-3UTRENST00000321300ENST00000575542BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-3UTRENST00000321300ENST00000575542BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-3UTRENST00000321300ENST00000575542BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-3UTRENST00000321300ENST00000575542BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-3UTRENST00000392411ENST00000575542BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-3UTRENST00000392411ENST00000575542BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-3UTRENST00000416299ENST00000575542BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-3UTRENST00000428708ENST00000575542BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-3UTRENST00000428708ENST00000575542BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-3UTRENST00000428708ENST00000575542BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-3UTRENST00000428708ENST00000575542BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-3UTRENST00000435091ENST00000575542BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-3UTRENST00000435091ENST00000575542BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-3UTRENST00000435091ENST00000575542BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-3UTRENST00000435091ENST00000575542BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-3UTRENST00000575245ENST00000575542BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-3UTRENST00000575245ENST00000575542BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-3UTRENST00000575245ENST00000575542BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-3UTRENST00000575245ENST00000575542BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-3UTRENST00000575712ENST00000575542BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-3UTRENST00000575712ENST00000575542BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-3UTRENST00000575712ENST00000575542BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-3UTRENST00000575712ENST00000575542BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000321280ENST00000306801BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000321280ENST00000306801BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000321280ENST00000306801BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000321280ENST00000306801BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000321280ENST00000537330BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000321280ENST00000537330BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000321280ENST00000537330BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000321280ENST00000537330BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000321280ENST00000544334BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000321280ENST00000544334BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000321280ENST00000544334BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000321280ENST00000544334BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000321280ENST00000570891BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000321280ENST00000570891BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000321280ENST00000570891BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000321280ENST00000570891BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000321300ENST00000306801BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000321300ENST00000306801BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000321300ENST00000306801BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000321300ENST00000306801BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000321300ENST00000537330BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000321300ENST00000537330BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000321300ENST00000537330BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000321300ENST00000537330BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000321300ENST00000544334BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000321300ENST00000544334BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000321300ENST00000544334BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000321300ENST00000544334BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000321300ENST00000570891BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000321300ENST00000570891BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000321300ENST00000570891BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000321300ENST00000570891BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000392411ENST00000306801BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000392411ENST00000306801BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000392411ENST00000537330BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000392411ENST00000537330BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000392411ENST00000544334BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000392411ENST00000544334BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000392411ENST00000570891BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000392411ENST00000570891BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000416299ENST00000306801BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000416299ENST00000537330BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000416299ENST00000544334BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000416299ENST00000570891BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000428708ENST00000306801BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000428708ENST00000306801BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000428708ENST00000306801BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000428708ENST00000306801BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000428708ENST00000537330BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000428708ENST00000537330BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000428708ENST00000537330BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000428708ENST00000537330BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000428708ENST00000544334BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000428708ENST00000544334BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000428708ENST00000544334BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000428708ENST00000544334BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000428708ENST00000570891BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000428708ENST00000570891BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000428708ENST00000570891BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000428708ENST00000570891BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000435091ENST00000306801BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000435091ENST00000306801BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000435091ENST00000306801BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000435091ENST00000306801BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000435091ENST00000537330BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000435091ENST00000537330BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000435091ENST00000537330BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000435091ENST00000537330BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000435091ENST00000544334BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000435091ENST00000544334BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000435091ENST00000544334BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000435091ENST00000544334BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000435091ENST00000570891BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000435091ENST00000570891BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000435091ENST00000570891BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000435091ENST00000570891BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000575245ENST00000306801BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000575245ENST00000306801BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000575245ENST00000306801BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000575245ENST00000306801BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000575245ENST00000537330BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000575245ENST00000537330BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000575245ENST00000537330BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000575245ENST00000537330BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000575245ENST00000544334BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000575245ENST00000544334BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000575245ENST00000544334BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000575245ENST00000544334BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000575245ENST00000570891BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000575245ENST00000570891BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000575245ENST00000570891BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000575245ENST00000570891BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000575712ENST00000306801BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000575712ENST00000306801BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000575712ENST00000306801BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000575712ENST00000306801BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000575712ENST00000537330BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000575712ENST00000537330BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000575712ENST00000537330BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000575712ENST00000537330BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000575712ENST00000544334BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000575712ENST00000544334BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000575712ENST00000544334BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000575712ENST00000544334BAIAP2chr17

79031767

+RPTORchr17

78882610

+
5CDS-intronENST00000575712ENST00000570891BAIAP2chr17

79079946

+RPTORchr17

78914295

+
5CDS-intronENST00000575712ENST00000570891BAIAP2chr17

79060380

+RPTORchr17

78914296

+
5CDS-intronENST00000575712ENST00000570891BAIAP2chr17

79031767

+RPTORchr17

78882611

+
5CDS-intronENST00000575712ENST00000570891BAIAP2chr17

79031767

+RPTORchr17

78882610

+
intron-3UTRENST00000392411ENST00000575542BAIAP2chr17

79031767

+RPTORchr17

78882611

+
intron-3UTRENST00000392411ENST00000575542BAIAP2chr17

79031767

+RPTORchr17

78882610

+
intron-3UTRENST00000416299ENST00000575542BAIAP2chr17

79060380

+RPTORchr17

78914296

+
intron-3UTRENST00000416299ENST00000575542BAIAP2chr17

79031767

+RPTORchr17

78882611

+
intron-3UTRENST00000416299ENST00000575542BAIAP2chr17

79031767

+RPTORchr17

78882610

+
intron-3UTRENST00000573894ENST00000575542BAIAP2chr17

79079946

+RPTORchr17

78914295

+
intron-intronENST00000392411ENST00000306801BAIAP2chr17

79031767

+RPTORchr17

78882611

+
intron-intronENST00000392411ENST00000306801BAIAP2chr17

79031767

+RPTORchr17

78882610

+
intron-intronENST00000392411ENST00000537330BAIAP2chr17

79031767

+RPTORchr17

78882611

+
intron-intronENST00000392411ENST00000537330BAIAP2chr17

79031767

+RPTORchr17

78882610

+
intron-intronENST00000392411ENST00000544334BAIAP2chr17

79031767

+RPTORchr17

78882611

+
intron-intronENST00000392411ENST00000544334BAIAP2chr17

79031767

+RPTORchr17

78882610

+
intron-intronENST00000392411ENST00000570891BAIAP2chr17

79031767

+RPTORchr17

78882611

+
intron-intronENST00000392411ENST00000570891BAIAP2chr17

79031767

+RPTORchr17

78882610

+
intron-intronENST00000416299ENST00000306801BAIAP2chr17

79060380

+RPTORchr17

78914296

+
intron-intronENST00000416299ENST00000306801BAIAP2chr17

79031767

+RPTORchr17

78882611

+
intron-intronENST00000416299ENST00000306801BAIAP2chr17

79031767

+RPTORchr17

78882610

+
intron-intronENST00000416299ENST00000537330BAIAP2chr17

79060380

+RPTORchr17

78914296

+
intron-intronENST00000416299ENST00000537330BAIAP2chr17

79031767

+RPTORchr17

78882611

+
intron-intronENST00000416299ENST00000537330BAIAP2chr17

79031767

+RPTORchr17

78882610

+
intron-intronENST00000416299ENST00000544334BAIAP2chr17

79060380

+RPTORchr17

78914296

+
intron-intronENST00000416299ENST00000544334BAIAP2chr17

79031767

+RPTORchr17

78882611

+
intron-intronENST00000416299ENST00000544334BAIAP2chr17

79031767

+RPTORchr17

78882610

+
intron-intronENST00000416299ENST00000570891BAIAP2chr17

79060380

+RPTORchr17

78914296

+
intron-intronENST00000416299ENST00000570891BAIAP2chr17

79031767

+RPTORchr17

78882611

+
intron-intronENST00000416299ENST00000570891BAIAP2chr17

79031767

+RPTORchr17

78882610

+
intron-intronENST00000573894ENST00000306801BAIAP2chr17

79079946

+RPTORchr17

78914295

+
intron-intronENST00000573894ENST00000537330BAIAP2chr17

79079946

+RPTORchr17

78914295

+
intron-intronENST00000573894ENST00000544334BAIAP2chr17

79079946

+RPTORchr17

78914295

+
intron-intronENST00000573894ENST00000570891BAIAP2chr17

79079946

+RPTORchr17

78914295

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for BAIAP2-RPTOR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BAIAP2chr1779079946+RPTORchr1778914295+0.0080878030.9919121
BAIAP2chr1779060380+RPTORchr1778914295+6.96E-070.9999993
BAIAP2chr1779031767+RPTORchr1778882610+2.14E-081
BAIAP2chr1779031767+RPTORchr1778882610+2.14E-081
BAIAP2chr1779079946+RPTORchr1778914295+0.0080878030.9919121
BAIAP2chr1779060380+RPTORchr1778914295+6.96E-070.9999993
BAIAP2chr1779031767+RPTORchr1778882610+2.14E-081
BAIAP2chr1779031767+RPTORchr1778882610+2.14E-081


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BAIAP2-RPTOR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:79079946/:78914295)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BAIAP2

Q9UQB8

.
FUNCTION: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for BAIAP2-RPTOR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for BAIAP2-RPTOR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BAIAP2-RPTOR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BAIAP2-RPTOR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0028043Nicotine Dependence1CTD_human
TgeneC0040332Tobacco Dependence1CTD_human
TgeneC0376384Nicotine Use Disorder1CTD_human