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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FST-FST (FusionGDB2 ID:HG10468TG10468)

Fusion Gene Summary for FST-FST

check button Fusion gene summary
Fusion gene informationFusion gene name: FST-FST
Fusion gene ID: hg10468tg10468
HgeneTgene
Gene symbol

FST

FST

Gene ID

10468

10468

Gene namefollistatinfollistatin
SynonymsFSFS
Cytomap('FST')('FST')

5q11.2

5q11.2

Type of geneprotein-codingprotein-coding
Descriptionfollistatinactivin-binding proteinfollistatin isoform FST317follistatinactivin-binding proteinfollistatin isoform FST317
Modification date2020032220200322
UniProtAcc

P19883

P19883

Ensembl transtripts involved in fusion geneENST00000256759, ENST00000396947, 
ENST00000256759, ENST00000396947, 
Fusion gene scores* DoF score1 X 2 X 1=26 X 6 X 3=108
# samples 27
** MAII scorelog2(2/2*10)=3.32192809488736log2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FST [Title/Abstract] AND FST [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFST(52776574)-FST(52778800), # samples:1
FST(52782465)-FST(52782538), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFST

GO:0000122

negative regulation of transcription by RNA polymerase II

12702211

HgeneFST

GO:0002244

hematopoietic progenitor cell differentiation

15451575

HgeneFST

GO:0032926

negative regulation of activin receptor signaling pathway

11948405|12697670

HgeneFST

GO:0051798

positive regulation of hair follicle development

12514121

TgeneFST

GO:0000122

negative regulation of transcription by RNA polymerase II

12702211

TgeneFST

GO:0002244

hematopoietic progenitor cell differentiation

15451575

TgeneFST

GO:0032926

negative regulation of activin receptor signaling pathway

11948405|12697670

TgeneFST

GO:0051798

positive regulation of hair follicle development

12514121



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for FST-FST

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FST-FST


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for FST-FST


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:52776574/:52778800)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FST

P19883

FST

P19883

FUNCTION: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).FUNCTION: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FST-FST


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FST-FST


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FST-FST


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FST-FST


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFSTC2239176Liver carcinoma2CTD_human
HgeneFSTC0000786Spontaneous abortion1CTD_human
HgeneFSTC0000822Abortion, Tubal1CTD_human
HgeneFSTC0006142Malignant neoplasm of breast1CTD_human
HgeneFSTC0023903Liver neoplasms1CTD_human
HgeneFSTC0024623Malignant neoplasm of stomach1CTD_human
HgeneFSTC0038356Stomach Neoplasms1CTD_human
HgeneFSTC0162557Liver Failure, Acute1CTD_human
HgeneFSTC0345904Malignant neoplasm of liver1CTD_human
HgeneFSTC0678222Breast Carcinoma1CTD_human
HgeneFSTC1257931Mammary Neoplasms, Human1CTD_human
HgeneFSTC1458155Mammary Neoplasms1CTD_human
HgeneFSTC1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneFSTC3830362Early Pregnancy Loss1CTD_human
HgeneFSTC4552766Miscarriage1CTD_human
HgeneFSTC4704874Mammary Carcinoma, Human1CTD_human
TgeneC2239176Liver carcinoma2CTD_human
TgeneC0000786Spontaneous abortion1CTD_human
TgeneC0000822Abortion, Tubal1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0023903Liver neoplasms1CTD_human
TgeneC0024623Malignant neoplasm of stomach1CTD_human
TgeneC0038356Stomach Neoplasms1CTD_human
TgeneC0162557Liver Failure, Acute1CTD_human
TgeneC0345904Malignant neoplasm of liver1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneC3830362Early Pregnancy Loss1CTD_human
TgeneC4552766Miscarriage1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human