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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADARB1-MTOR (FusionGDB2 ID:HG104TG2475)

Fusion Gene Summary for ADARB1-MTOR

check button Fusion gene summary
Fusion gene informationFusion gene name: ADARB1-MTOR
Fusion gene ID: hg104tg2475
HgeneTgene
Gene symbol

ADARB1

MTOR

Gene ID

104

2475

Gene nameadenosine deaminase RNA specific B1mechanistic target of rapamycin kinase
SynonymsADAR2|DRABA2|DRADA2|RED1FRAP|FRAP1|FRAP2|RAFT1|RAPT1|SKS
Cytomap('ADARB1')('MTOR')

21q22.3

1p36.22

Type of geneprotein-codingprotein-coding
Descriptiondouble-stranded RNA-specific editase 1RNA editing deaminase 1RNA-editing enzyme 1adenosine deaminase, RNA-specific, B1 (homolog of rat RED1)dsRNA adenosine deaminase DRADA2serine/threonine-protein kinase mTORFK506 binding protein 12-rapamycin associated protein 2FK506-binding protein 12-rapamycin complex-associated protein 1FKBP-rapamycin associated proteinFKBP12-rapamycin complex-associated protein 1mammalian target o
Modification date2020031520200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000460734, ENST00000348831, 
ENST00000389863, ENST00000437626, 
ENST00000539173, ENST00000360697, 
Fusion gene scores* DoF score3 X 4 X 2=2412 X 11 X 8=1056
# samples 419
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(19/1056*10)=-2.47453851102751
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADARB1 [Title/Abstract] AND MTOR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADARB1(46494708)-MTOR(11227574), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADARB1

GO:0006382

adenosine to inosine editing

18178553|21289159

HgeneADARB1

GO:0008285

negative regulation of cell proliferation

18178553

HgeneADARB1

GO:0030336

negative regulation of cell migration

18178553

HgeneADARB1

GO:0044387

negative regulation of protein kinase activity by regulation of protein phosphorylation

21289159

HgeneADARB1

GO:0051726

regulation of cell cycle

18178553

TgeneMTOR

GO:0001558

regulation of cell growth

18762023

TgeneMTOR

GO:0001934

positive regulation of protein phosphorylation

20233713

TgeneMTOR

GO:0006468

protein phosphorylation

12150926|15467718|18925875

TgeneMTOR

GO:0009267

cellular response to starvation

28223137

TgeneMTOR

GO:0010507

negative regulation of autophagy

30704899

TgeneMTOR

GO:0016242

negative regulation of macroautophagy

25327288

TgeneMTOR

GO:0016310

phosphorylation

11853878|25327288

TgeneMTOR

GO:0031667

response to nutrient levels

29750193

TgeneMTOR

GO:0034198

cellular response to amino acid starvation

22424946

TgeneMTOR

GO:0038202

TORC1 signaling

28223137

TgeneMTOR

GO:0043200

response to amino acid

18497260

TgeneMTOR

GO:0045727

positive regulation of translation

18762023

TgeneMTOR

GO:0046777

protein autophosphorylation

15467718

TgeneMTOR

GO:0071230

cellular response to amino acid stimulus

22424946

TgeneMTOR

GO:0071233

cellular response to leucine

22424946

TgeneMTOR

GO:1990253

cellular response to leucine starvation

22424946



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-B7-5818-01AADARB1chr21

46494708

+MTORchr1

11227574

-


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Fusion Gene ORF analysis for ADARB1-MTOR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000460734ENST00000361445ADARB1chr21

46494708

+MTORchr1

11227574

-
3UTR-intronENST00000460734ENST00000376838ADARB1chr21

46494708

+MTORchr1

11227574

-
3UTR-intronENST00000460734ENST00000495435ADARB1chr21

46494708

+MTORchr1

11227574

-
5UTR-3CDSENST00000348831ENST00000361445ADARB1chr21

46494708

+MTORchr1

11227574

-
5UTR-3CDSENST00000389863ENST00000361445ADARB1chr21

46494708

+MTORchr1

11227574

-
5UTR-3CDSENST00000437626ENST00000361445ADARB1chr21

46494708

+MTORchr1

11227574

-
5UTR-3CDSENST00000539173ENST00000361445ADARB1chr21

46494708

+MTORchr1

11227574

-
5UTR-intronENST00000348831ENST00000376838ADARB1chr21

46494708

+MTORchr1

11227574

-
5UTR-intronENST00000348831ENST00000495435ADARB1chr21

46494708

+MTORchr1

11227574

-
5UTR-intronENST00000389863ENST00000376838ADARB1chr21

46494708

+MTORchr1

11227574

-
5UTR-intronENST00000389863ENST00000495435ADARB1chr21

46494708

+MTORchr1

11227574

-
5UTR-intronENST00000437626ENST00000376838ADARB1chr21

46494708

+MTORchr1

11227574

-
5UTR-intronENST00000437626ENST00000495435ADARB1chr21

46494708

+MTORchr1

11227574

-
5UTR-intronENST00000539173ENST00000376838ADARB1chr21

46494708

+MTORchr1

11227574

-
5UTR-intronENST00000539173ENST00000495435ADARB1chr21

46494708

+MTORchr1

11227574

-
intron-3CDSENST00000360697ENST00000361445ADARB1chr21

46494708

+MTORchr1

11227574

-
intron-intronENST00000360697ENST00000376838ADARB1chr21

46494708

+MTORchr1

11227574

-
intron-intronENST00000360697ENST00000495435ADARB1chr21

46494708

+MTORchr1

11227574

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ADARB1-MTOR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ADARB1-MTOR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:46494708/:11227574)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ADARB1-MTOR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ADARB1-MTOR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADARB1-MTOR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADARB1-MTOR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADARB1C0005586Bipolar Disorder3PSYGENET
HgeneADARB1C0036341Schizophrenia2PSYGENET
HgeneADARB1C0032460Polycystic Ovary Syndrome1CTD_human
HgeneADARB1C0033975Psychotic Disorders1PSYGENET
HgeneADARB1C1136382Sclerocystic Ovaries1CTD_human
TgeneC1846385FOCAL CORTICAL DYSPLASIA OF TAYLOR5CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC4225259SMITH-KINGSMORE SYNDROME5GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0041696Unipolar Depression2PSYGENET
TgeneC0919267ovarian neoplasm2CTD_human
TgeneC1140680Malignant neoplasm of ovary2CTD_human
TgeneC1269683Major Depressive Disorder2PSYGENET
TgeneC0001418Adenocarcinoma1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0007102Malignant tumor of colon1CTD_human
TgeneC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneC0007134Renal Cell Carcinoma1CTD_human
TgeneC0007873Uterine Cervical Neoplasm1CTD_human
TgeneC0009375Colonic Neoplasms1CTD_human
TgeneC0014130Endocrine System Diseases1CTD_human
TgeneC0017636Glioblastoma1CTD_human
TgeneC0020538Hypertensive disease1CTD_human
TgeneC0024232Lymphatic Metastasis1CTD_human
TgeneC0025500Mesothelioma1CTD_human
TgeneC0034069Pulmonary Fibrosis1CTD_human
TgeneC0036341Schizophrenia1CTD_human
TgeneC0149504Encephalopathy, Toxic1CTD_human
TgeneC0149721Left Ventricular Hypertrophy1CTD_human
TgeneC0154659Toxic Encephalitis1CTD_human
TgeneC0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneC0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneC0205643Carcinoma, Cribriform1CTD_human
TgeneC0205644Carcinoma, Granular Cell1CTD_human
TgeneC0205645Adenocarcinoma, Tubular1CTD_human
TgeneC0235032Neurotoxicity Syndromes1CTD_human
TgeneC0262584Carcinoma, Small Cell1CTD_human
TgeneC0267963Exocrine pancreatic insufficiency1CTD_human
TgeneC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CGI;CTD_human
TgeneC0334588Giant Cell Glioblastoma1CTD_human
TgeneC0334634Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse1CTD_human
TgeneC0431380Cortical Dysplasia1CTD_human
TgeneC0431391Hemimegalencephaly1GENOMICS_ENGLAND
TgeneC0543888Epileptic encephalopathy1GENOMICS_ENGLAND
TgeneC0588006Mild depression1PSYGENET
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0751958Lymphoma, Lymphocytic, Intermediate1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneC1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1621958Glioblastoma Multiforme1CTD_human;UNIPROT
TgeneC1955869Malformations of Cortical Development1CTD_human
TgeneC1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
TgeneC2239176Liver carcinoma1CTD_human
TgeneC3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneC4048328cervical cancer1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human
TgeneC4721507Alveolitis, Fibrosing1CTD_human