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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CIB2-OLA1 (FusionGDB2 ID:HG10518TG29789)

Fusion Gene Summary for CIB2-OLA1

check button Fusion gene summary
Fusion gene informationFusion gene name: CIB2-OLA1
Fusion gene ID: hg10518tg29789
HgeneTgene
Gene symbol

CIB2

OLA1

Gene ID

10518

29789

Gene namecalcium and integrin binding family member 2Obg like ATPase 1
SynonymsDFNB48|KIP2|USH1JDOC45|GBP45|GTBP9|GTPBP9|PTD004
Cytomap('CIB2')('OLA1')

15q25.1

2q31.1

Type of geneprotein-codingprotein-coding
Descriptioncalcium and integrin-binding family member 2DNA-dependent protein kinase catalytic subunit-interacting protein 2obg-like ATPase 1DNA damage-regulated overexpressed in cancer 45 proteinGTP-binding protein 9 (putative)GTP-binding protein PTD004homologous yeast-44.2 protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000539011, ENST00000258930, 
ENST00000557846, ENST00000560618, 
Fusion gene scores* DoF score2 X 3 X 2=1214 X 8 X 7=784
# samples 214
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(14/784*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CIB2 [Title/Abstract] AND OLA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCIB2(78396992)-OLA1(174940167), # samples:1
Anticipated loss of major functional domain due to fusion event.CIB2-OLA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CIB2-OLA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CIB2-OLA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CIB2-OLA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCIB2

GO:0007204

positive regulation of cytosolic calcium ion concentration

23023331|26173970

HgeneCIB2

GO:0071318

cellular response to ATP

23023331|26173970

TgeneOLA1

GO:0046034

ATP metabolic process

17430889


check buttonFusion gene breakpoints across CIB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across OLA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-CG-5730-11ACIB2chr15

78396992

-OLA1chr2

174940167

-


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Fusion Gene ORF analysis for CIB2-OLA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000539011ENST00000392560CIB2chr15

78396992

-OLA1chr2

174940167

-
Frame-shiftENST00000539011ENST00000409546CIB2chr15

78396992

-OLA1chr2

174940167

-
In-frameENST00000539011ENST00000284719CIB2chr15

78396992

-OLA1chr2

174940167

-
In-frameENST00000539011ENST00000344357CIB2chr15

78396992

-OLA1chr2

174940167

-
In-frameENST00000539011ENST00000428402CIB2chr15

78396992

-OLA1chr2

174940167

-
intron-3CDSENST00000258930ENST00000284719CIB2chr15

78396992

-OLA1chr2

174940167

-
intron-3CDSENST00000258930ENST00000344357CIB2chr15

78396992

-OLA1chr2

174940167

-
intron-3CDSENST00000258930ENST00000409546CIB2chr15

78396992

-OLA1chr2

174940167

-
intron-3CDSENST00000258930ENST00000428402CIB2chr15

78396992

-OLA1chr2

174940167

-
intron-3CDSENST00000557846ENST00000284719CIB2chr15

78396992

-OLA1chr2

174940167

-
intron-3CDSENST00000557846ENST00000344357CIB2chr15

78396992

-OLA1chr2

174940167

-
intron-3CDSENST00000557846ENST00000409546CIB2chr15

78396992

-OLA1chr2

174940167

-
intron-3CDSENST00000557846ENST00000428402CIB2chr15

78396992

-OLA1chr2

174940167

-
intron-3CDSENST00000560618ENST00000284719CIB2chr15

78396992

-OLA1chr2

174940167

-
intron-3CDSENST00000560618ENST00000344357CIB2chr15

78396992

-OLA1chr2

174940167

-
intron-3CDSENST00000560618ENST00000409546CIB2chr15

78396992

-OLA1chr2

174940167

-
intron-3CDSENST00000560618ENST00000428402CIB2chr15

78396992

-OLA1chr2

174940167

-
intron-5UTRENST00000258930ENST00000392560CIB2chr15

78396992

-OLA1chr2

174940167

-
intron-5UTRENST00000557846ENST00000392560CIB2chr15

78396992

-OLA1chr2

174940167

-
intron-5UTRENST00000560618ENST00000392560CIB2chr15

78396992

-OLA1chr2

174940167

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000539011CIB2chr1578396992-ENST00000284719OLA1chr2174940167-4504151112061700164
ENST00000539011CIB2chr1578396992-ENST00000344357OLA1chr2174940167-1943151112061700164
ENST00000539011CIB2chr1578396992-ENST00000428402OLA1chr2174940167-1941151112061700164

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000539011ENST00000284719CIB2chr1578396992-OLA1chr2174940167-0.0019808690.9980191
ENST00000539011ENST00000344357CIB2chr1578396992-OLA1chr2174940167-0.0048545510.9951454
ENST00000539011ENST00000428402CIB2chr1578396992-OLA1chr2174940167-0.0048414250.9951586

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Fusion Genomic Features for CIB2-OLA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CIB2-OLA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:78396992/chr2:174940167)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneOLA1chr15:78396992chr2:174940167ENST0000028471901123_2830397.0DomainOBG-type G
TgeneOLA1chr15:78396992chr2:174940167ENST00000284719011304_3870397.0DomainTGS
TgeneOLA1chr15:78396992chr2:174940167ENST0000034435701023_2830239.0DomainOBG-type G
TgeneOLA1chr15:78396992chr2:174940167ENST00000344357010304_3870239.0DomainTGS
TgeneOLA1chr15:78396992chr2:174940167ENST000004284020823_2830279.0DomainOBG-type G
TgeneOLA1chr15:78396992chr2:174940167ENST0000042840208304_3870279.0DomainTGS
TgeneOLA1chr15:78396992chr2:174940167ENST00000284719011267_2740397.0MotifNuclear export signal
TgeneOLA1chr15:78396992chr2:174940167ENST00000344357010267_2740239.0MotifNuclear export signal
TgeneOLA1chr15:78396992chr2:174940167ENST0000042840208267_2740279.0MotifNuclear export signal
TgeneOLA1chr15:78396992chr2:174940167ENST0000028471901132_370397.0Nucleotide bindingATP
TgeneOLA1chr15:78396992chr2:174940167ENST0000034435701032_370239.0Nucleotide bindingATP
TgeneOLA1chr15:78396992chr2:174940167ENST000004284020832_370279.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCIB2chr15:78396992chr2:174940167ENST00000258930-16116_1270188.0Calcium binding1
HgeneCIB2chr15:78396992chr2:174940167ENST00000258930-16157_1680188.0Calcium binding2
HgeneCIB2chr15:78396992chr2:174940167ENST00000258930-16103_1380188.0DomainEF-hand 2
HgeneCIB2chr15:78396992chr2:174940167ENST00000258930-16144_1790188.0DomainEF-hand 3
HgeneCIB2chr15:78396992chr2:174940167ENST00000258930-1666_1010188.0DomainEF-hand 1


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Fusion Gene Sequence for CIB2-OLA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16785_16785_1_CIB2-OLA1_CIB2_chr15_78396992_ENST00000539011_OLA1_chr2_174940167_ENST00000284719_length(transcript)=4504nt_BP=1511nt
AAGGGTTCGTGCCGGGCAGCGTCTCCCGGGGCCAGGTCGCCTCCTGCCGGGACCCGGGCGCGCTGCAGCCGCGGAGCCGGGTGCCCCGCC
CTCTTCCCGCCGGCGGCGGAGTCGCTGCCGCTCCGGGTTCCCGTCCCCGCCTCCGAGACCCCCGCGCGCCTCCTCCAGGCGAGCTGCGGG
GCGGGAAGGGTCCGGCCACCGTGGGCCGCTGCCAGCCGCGGGGCTGCCGAGGGCCGCGGGCACGGGGCGCTGGCTCCGGGTCTGGCGGCC
GCTGATGGGAGTCGGAGCCCGGGCGGGCGAGCGGCGGCGCGGCGGCCACCATGGGGAACAAGCAGACCATCTTCACCGAAGAGCAGCTAG
ACAACTACCAGGCTGCATTCGCGATTCTATGAGCTGGCCCCCAACCTCGTCCCAATGGACTACAGGAAGAGCCCCATCGTCCACGTGCCC
ATGAGCCTCATCATCCAGATGCCAGAGCTCCGGGAGAATCCCTTCAAAGAAAGGATCGTGGCGGCGTTTTCCGAGGATGGTGAGGGGAAC
CTCACTTTCAACGACTTTGTGGACATGTTTTCCGTGCTCTGCGAGTCGGCTCCCCGAGAGCTCAAGGCAAACTATGCCTTCAAGATCTAT
GACTTCAACACTGACAACTTCATCTGCAAGGAGGACCTGGAGCTGACGCTGGCCCGGCTCACTAAGTCAGAGCTGGATGAGGAGGAGGTG
GTGCTTGTGTGCGACAAGGTCATTGAGGAGGCTGACTTGGACGGTGACGGCAAGCTGGGCTTTGCTGACTTCGAGGACATGATTGCCAAG
GCCCCTGACTTCCTCAGCACTTTCCACATCCGGATCTGAGGACACTGCCGAGGCTGTAGGGGCCTAGAAGTCCACCATCCTGCCCTGCAG
TCACATGGGTGTGGCCTCCAAGCTCCCCAGGAAAGCAGTGGCAGCCTCTGGGGTTTACACCACAAATATATCCTGTGGCCCTTTCAGCAA
AAAAAAAACCTTAACCAGGAAGGGGGCCTGTGAAGGTTAGGACCCTTCCCACAGCCCCGCTGTGGTCCAGCCCCGGGACCCATGGCCTCT
CTCCAGGCCCTCCGCACCCCGCCCCATGCCCCAGTCCTTTCCTACTCCAGAAATGCTCCCCACCCCCCCAAAGAGGGAAAAGCAGATAAC
CCAACAGGAGGTGGTGGGGTCTGACGTGTCCAAGTGCTGGCAGACACCCTGGTCACCCAGGACAGAGCGGAAAAAAAAAAAAGAGGTCAG
GGTTTTAACGAGCTATGCAATCTTTTTCCAAAACCCAAGGTTGGGCTGCTTCCCACCCCTGCCTGTTCCCCTTCTCCCGGCCTCCTTCAC
AATGTGAAGCTGTGGGTGCAGTGGGCCCAAGGGCTCTTGCTCCTGTCTCTGCCTCTGGGTCATGAGTACCACCCTGCCTGCCTCCCCAAC
ACCGTGGAATCCTCACTGGTGTGCTGTCCACAGATTTGTGAACTCCTGGTAGTAAAACACTTTTGCATCCCCGAAGAAGAAATAAAATTT
AGTTATTGCTCAGATAAACATACAACTTCCAAAAGGCATCTGATTTTTAAAAAATTAAAATTTCTGAAAACCAATGCGACAAATAAAGTT
GGGGAGATGGGAATCTTTGACAAACAAATTATTTTTATTTGTTTTAAAATTAAAATACTGTGTACCCCCCCCCCCCCATGAAATGCAGGT
TCACTAAATGTGAACAGCTTTGCTTTTCACGTGATTAAGACCCTACTCCAAATTGTAGAAGCTTTTCAGGAACCATATTACTCTCATGAT
ACTTCATTAATCTCCATCATGTATGCCAAGCCTGACACATTTGACAGTGAGGACAATGTGGCTTGCTCCTTTTTGAATCTACAGATAATG
CATGTTTTACAGTACTCCAGATGTCTACACTCAATAAAACATTTGACAAAACCAGCCTTGGTGTGTTTGGGGATGTCTGTATTGACTGAC
TGTGGTGTGCTGAATGCGATACGGCACCTGGTGGTTGCTGATTACAGAATTTTAAGGCGTGTGTATGACACAGTAACTGGCAGTGTGGGG
CAGCTGCAATTGTATCTTAAAAGTGAGTCTTTCATGGGAATCAGAAGAATAGTATACCAGGGATTTGTCTCAAAAAAGTTAATTAATTTA
TAGATCAACATTTATTGAAAGATGATAGCAATGATATTATGAGGGATATGAGATAGGTGACTGACCACAAAGAAGAAAATTCTGTCTCAA
AAATTAAAGAATTTTGTTTGTTATTGTTGTTCTGACCATATTGAAAAGAGGTTCACTTTTAATCTTTCCTTTGAAATTATTAAATTGTAA
AAACTGACCCATTGATGTCTGGTGGGTTATGTTTTGCTTCAATTCAGCAATGTGTATAAAAGTTCCTACACTGATTTTGAAATACTAAGA
TCAGACTTTGAAAATTTTAAAAATTCTTTCATTCTTACTTTTCAGATATTTGAGAGCAGTCGAAGTGGTAGTATGGGTAAGTTAAGCACT
TCTTAACATTGTAGCAGAAAATTCCAAAAGAAAGACTAGAACAAATTGGTAATTTGGAGACCCTTTGCCACTTAGCCTTCTCTTGTGATG
ATGGCCTGAAAGCTCTCTCGGCCCTGAGCCTCCCTTTCTCTCCCATGTTTCCATTCCTGTGAGACCTCCCTTCCTTGTCCTTGTCCTCTG
CCCTTTTGTGCTCTTCTGTGATCACAGGACCATTTCCATGGAATGCAGATTCATACCCAGCCAGCCTTTGCCTCTACTGTATCGCTTTGG
GACTTTAAAGATGCAGAAGTATTAGAACACACACAAACTTAAAATGGAAAGTTACCAAATGTAGCACTAGAGGCAAGAAAAGGGGTGATT
TTTTAAAGATTTGGCTATACTTAAGATATTTAAAGAGGATGAGGTTGAGTCGTGAGTATAATTTAGAAGCTCTCCAGTGAGTATTTTTTT
AGTATCAAATAGTGATCTTCTTTTGCTAACATAAAAATGAGTAAACTACAGCAGAGAAATAAGAATAAAACTAATGAAGGGTTTTTTAAA
AGAACTAAATAAAACAAATAAAACTAGGCTACAGGTATAGCTGACCAAGTTTGCTGTGAAAAATCCTTGTTATATCTATTTCTGTATTGG
AGTAATGTGTAGATTAGTGGATTGTTAGGGATTTCAGCAGTATAAGAAAGAATCAAATATCTTGCTTTTGGGTCTTCTCCAAAGTAAATT
GCATGGACTTCTTAAAGAAGTTTGAAATCAGTAAAAAGACATTAGGATCATGCAATTTTACTTTGTCTAGCTTCTAATGTGGTAAATTGC
ACATTGTGCAACAGAACCATTAATAAAAGAAAGGAGTTAGTTTTGAGGTAACTGCATTCATTAGGGGCTGAAAATAAATGTTAAAAATGT
TTAATTTGGTTAGAAGTTCTACAACATTGTATGTACATATACAAAATTTCATTTTCTCTGAAAGTCGAGAATTCCAAGAACTGTTACATA
TAATCATATATATGCCTATATCTAAACGTTTTCCCTCCTTTAATATTGATAAAGTTAATATATTTTAGGATGTTATGTAAATATTTTTGC
ATGTATCTGTAGCTCCATCTTAATCAAATTTATGGTTAAAAGAGATTTGAGGCCAGGCGTGGAGGCTCACACCTATAATCCCAACACTTT
GGGAGGCCGAGGTGGGAGGATCACTTGAGCACAGGAGTTTGAGACCAGCCTGTGCAACATCATGAAACATCATCTCTACATAAAAAAATA
CATATATACAAAAATTAGCTGGGCATCATGGCACACACCTGTAGTCCCAGCTACTTAGGAGGCTGAGATGGGAGGATTGATCGATCGCTT
GAGCCTGGGAGGTGGAGGCTACTGTGAGCCATGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGTGAGACCCTGTCTCCAAAGAGAA
AGAGAAACTTGAGAAGGCTTGTGCCCAAAGCTTGAAGAAAGATTGTAATAGCATTTAGTTGTGTTTTATCATGTTATCTTCATAACATGC
ATTTTGCATATGGCTCAGAGCAGAGCCGGATCTCCCAAGGAAGCACAAATAGTTTTTGTCGCTAACTTAGTTATGAGTGAAGCCTCTGTT
CACTTATAACTTGCCAGTTTCATTGGTGGAATAAGTCCCCTTACTCATGATTCATCAATATTCCTATATTAAAATTCCAGTTTGATGTTT
GTCTCTAGTTGTCTGTGTATAATATTTCCAAAGCTCCTTTGTAAACCCCGTCTCCTTTCATTCAGAGAGTCAGAGACGGTATCTCCTCCT
CCTGCCTCTTCTATTGTTCTGATTAGTCTACTTAAATTCACTTGATGCTCTTTTTATTTTACAAGAGACTTGAGAAATGTCGGTTGTTCC
TAATGGCAAACTACTTTAGCTGGGAAAATTCATTTCAACTTATTTTAAGCTTGTAAAATACACTGTGGTGATAAAATAAAAGAGCTGGGT

>16785_16785_1_CIB2-OLA1_CIB2_chr15_78396992_ENST00000539011_OLA1_chr2_174940167_ENST00000284719_length(amino acids)=164AA_BP=102
MADTLVTQDRAEKKKRGQGFNELCNLFPKPKVGLLPTPACSPSPGLLHNVKLWVQWAQGLLLLSLPLGHEYHPACLPNTVESSLVCCPQI

--------------------------------------------------------------
>16785_16785_2_CIB2-OLA1_CIB2_chr15_78396992_ENST00000539011_OLA1_chr2_174940167_ENST00000344357_length(transcript)=1943nt_BP=1511nt
AAGGGTTCGTGCCGGGCAGCGTCTCCCGGGGCCAGGTCGCCTCCTGCCGGGACCCGGGCGCGCTGCAGCCGCGGAGCCGGGTGCCCCGCC
CTCTTCCCGCCGGCGGCGGAGTCGCTGCCGCTCCGGGTTCCCGTCCCCGCCTCCGAGACCCCCGCGCGCCTCCTCCAGGCGAGCTGCGGG
GCGGGAAGGGTCCGGCCACCGTGGGCCGCTGCCAGCCGCGGGGCTGCCGAGGGCCGCGGGCACGGGGCGCTGGCTCCGGGTCTGGCGGCC
GCTGATGGGAGTCGGAGCCCGGGCGGGCGAGCGGCGGCGCGGCGGCCACCATGGGGAACAAGCAGACCATCTTCACCGAAGAGCAGCTAG
ACAACTACCAGGCTGCATTCGCGATTCTATGAGCTGGCCCCCAACCTCGTCCCAATGGACTACAGGAAGAGCCCCATCGTCCACGTGCCC
ATGAGCCTCATCATCCAGATGCCAGAGCTCCGGGAGAATCCCTTCAAAGAAAGGATCGTGGCGGCGTTTTCCGAGGATGGTGAGGGGAAC
CTCACTTTCAACGACTTTGTGGACATGTTTTCCGTGCTCTGCGAGTCGGCTCCCCGAGAGCTCAAGGCAAACTATGCCTTCAAGATCTAT
GACTTCAACACTGACAACTTCATCTGCAAGGAGGACCTGGAGCTGACGCTGGCCCGGCTCACTAAGTCAGAGCTGGATGAGGAGGAGGTG
GTGCTTGTGTGCGACAAGGTCATTGAGGAGGCTGACTTGGACGGTGACGGCAAGCTGGGCTTTGCTGACTTCGAGGACATGATTGCCAAG
GCCCCTGACTTCCTCAGCACTTTCCACATCCGGATCTGAGGACACTGCCGAGGCTGTAGGGGCCTAGAAGTCCACCATCCTGCCCTGCAG
TCACATGGGTGTGGCCTCCAAGCTCCCCAGGAAAGCAGTGGCAGCCTCTGGGGTTTACACCACAAATATATCCTGTGGCCCTTTCAGCAA
AAAAAAAACCTTAACCAGGAAGGGGGCCTGTGAAGGTTAGGACCCTTCCCACAGCCCCGCTGTGGTCCAGCCCCGGGACCCATGGCCTCT
CTCCAGGCCCTCCGCACCCCGCCCCATGCCCCAGTCCTTTCCTACTCCAGAAATGCTCCCCACCCCCCCAAAGAGGGAAAAGCAGATAAC
CCAACAGGAGGTGGTGGGGTCTGACGTGTCCAAGTGCTGGCAGACACCCTGGTCACCCAGGACAGAGCGGAAAAAAAAAAAAGAGGTCAG
GGTTTTAACGAGCTATGCAATCTTTTTCCAAAACCCAAGGTTGGGCTGCTTCCCACCCCTGCCTGTTCCCCTTCTCCCGGCCTCCTTCAC
AATGTGAAGCTGTGGGTGCAGTGGGCCCAAGGGCTCTTGCTCCTGTCTCTGCCTCTGGGTCATGAGTACCACCCTGCCTGCCTCCCCAAC
ACCGTGGAATCCTCACTGGTGTGCTGTCCACAGATTTGTGAACTCCTGGTAGTAAAACACTTTTGCATCCCCGAAGAAGAAATAAAATTT
AGTTATTGCTCAGATAAACATACAACTTCCAAAAGGCATCTGATTTTTAAAAAATTAAAATTTCTGAAAACCAATGCGACAAATAAAGTT
GGGGAGATGGGAATCTTTGACAAACAAATTATTTTTATTTGTTTTAAAATTAAAATACTGTGTACCCCCCCCCCCCCATGAAATGCAGGT
TCACTAAATGTGAACAGCTTTGCTTTTCACGTGATTAAGACCCTACTCCAAATTGTAGAAGCTTTTCAGGAACCATATTACTCTCATGAT
ACTTCATTAATCTCCATCATGTATGCCAAGCCTGACACATTTGACAGTGAGGACAATGTGGCTTGCTCCTTTTTGAATCTACAGATAATG

>16785_16785_2_CIB2-OLA1_CIB2_chr15_78396992_ENST00000539011_OLA1_chr2_174940167_ENST00000344357_length(amino acids)=164AA_BP=102
MADTLVTQDRAEKKKRGQGFNELCNLFPKPKVGLLPTPACSPSPGLLHNVKLWVQWAQGLLLLSLPLGHEYHPACLPNTVESSLVCCPQI

--------------------------------------------------------------
>16785_16785_3_CIB2-OLA1_CIB2_chr15_78396992_ENST00000539011_OLA1_chr2_174940167_ENST00000428402_length(transcript)=1941nt_BP=1511nt
AAGGGTTCGTGCCGGGCAGCGTCTCCCGGGGCCAGGTCGCCTCCTGCCGGGACCCGGGCGCGCTGCAGCCGCGGAGCCGGGTGCCCCGCC
CTCTTCCCGCCGGCGGCGGAGTCGCTGCCGCTCCGGGTTCCCGTCCCCGCCTCCGAGACCCCCGCGCGCCTCCTCCAGGCGAGCTGCGGG
GCGGGAAGGGTCCGGCCACCGTGGGCCGCTGCCAGCCGCGGGGCTGCCGAGGGCCGCGGGCACGGGGCGCTGGCTCCGGGTCTGGCGGCC
GCTGATGGGAGTCGGAGCCCGGGCGGGCGAGCGGCGGCGCGGCGGCCACCATGGGGAACAAGCAGACCATCTTCACCGAAGAGCAGCTAG
ACAACTACCAGGCTGCATTCGCGATTCTATGAGCTGGCCCCCAACCTCGTCCCAATGGACTACAGGAAGAGCCCCATCGTCCACGTGCCC
ATGAGCCTCATCATCCAGATGCCAGAGCTCCGGGAGAATCCCTTCAAAGAAAGGATCGTGGCGGCGTTTTCCGAGGATGGTGAGGGGAAC
CTCACTTTCAACGACTTTGTGGACATGTTTTCCGTGCTCTGCGAGTCGGCTCCCCGAGAGCTCAAGGCAAACTATGCCTTCAAGATCTAT
GACTTCAACACTGACAACTTCATCTGCAAGGAGGACCTGGAGCTGACGCTGGCCCGGCTCACTAAGTCAGAGCTGGATGAGGAGGAGGTG
GTGCTTGTGTGCGACAAGGTCATTGAGGAGGCTGACTTGGACGGTGACGGCAAGCTGGGCTTTGCTGACTTCGAGGACATGATTGCCAAG
GCCCCTGACTTCCTCAGCACTTTCCACATCCGGATCTGAGGACACTGCCGAGGCTGTAGGGGCCTAGAAGTCCACCATCCTGCCCTGCAG
TCACATGGGTGTGGCCTCCAAGCTCCCCAGGAAAGCAGTGGCAGCCTCTGGGGTTTACACCACAAATATATCCTGTGGCCCTTTCAGCAA
AAAAAAAACCTTAACCAGGAAGGGGGCCTGTGAAGGTTAGGACCCTTCCCACAGCCCCGCTGTGGTCCAGCCCCGGGACCCATGGCCTCT
CTCCAGGCCCTCCGCACCCCGCCCCATGCCCCAGTCCTTTCCTACTCCAGAAATGCTCCCCACCCCCCCAAAGAGGGAAAAGCAGATAAC
CCAACAGGAGGTGGTGGGGTCTGACGTGTCCAAGTGCTGGCAGACACCCTGGTCACCCAGGACAGAGCGGAAAAAAAAAAAAGAGGTCAG
GGTTTTAACGAGCTATGCAATCTTTTTCCAAAACCCAAGGTTGGGCTGCTTCCCACCCCTGCCTGTTCCCCTTCTCCCGGCCTCCTTCAC
AATGTGAAGCTGTGGGTGCAGTGGGCCCAAGGGCTCTTGCTCCTGTCTCTGCCTCTGGGTCATGAGTACCACCCTGCCTGCCTCCCCAAC
ACCGTGGAATCCTCACTGGTGTGCTGTCCACAGATTTGTGAACTCCTGGTAGTAAAACACTTTTGCATCCCCGAAGAAGAAATAAAATTT
AGTTATTGCTCAGATAAACATACAACTTCCAAAAGGCATCTGATTTTTAAAAAATTAAAATTTCTGAAAACCAATGCGACAAATAAAGTT
GGGGAGATGGGAATCTTTGACAAACAAATTATTTTTATTTGTTTTAAAATTAAAATACTGTGTACCCCCCCCCCCCCATGAAATGCAGGT
TCACTAAATGTGAACAGCTTTGCTTTTCACGTGATTAAGACCCTACTCCAAATTGTAGAAGCTTTTCAGGAACCATATTACTCTCATGAT
ACTTCATTAATCTCCATCATGTATGCCAAGCCTGACACATTTGACAGTGAGGACAATGTGGCTTGCTCCTTTTTGAATCTACAGATAATG

>16785_16785_3_CIB2-OLA1_CIB2_chr15_78396992_ENST00000539011_OLA1_chr2_174940167_ENST00000428402_length(amino acids)=164AA_BP=102
MADTLVTQDRAEKKKRGQGFNELCNLFPKPKVGLLPTPACSPSPGLLHNVKLWVQWAQGLLLLSLPLGHEYHPACLPNTVESSLVCCPQI

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Fusion Gene PPI Analysis for CIB2-OLA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CIB2-OLA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CIB2-OLA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCIB2C3711374Nonsyndromic Deafness8CLINGEN
HgeneCIB2C1836199DEAFNESS, AUTOSOMAL RECESSIVE 484CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneCIB2C3553944USHER SYNDROME, TYPE IJ2CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneCIB2C1384666hearing impairment1GENOMICS_ENGLAND
HgeneCIB2C1568247Usher Syndrome, Type I1ORPHANET