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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARFGEF2-TTLL9 (FusionGDB2 ID:HG10564TG164395)

Fusion Gene Summary for ARFGEF2-TTLL9

check button Fusion gene summary
Fusion gene informationFusion gene name: ARFGEF2-TTLL9
Fusion gene ID: hg10564tg164395
HgeneTgene
Gene symbol

ARFGEF2

TTLL9

Gene ID

10564

164395

Gene nameADP ribosylation factor guanine nucleotide exchange factor 2tubulin tyrosine ligase like 9
SynonymsBIG2|PVNH2|dJ1164I10.1C20orf125
Cytomap('ARFGEF2')('TTLL9')

20q13.13

20q11.21

Type of geneprotein-codingprotein-coding
Descriptionbrefeldin A-inhibited guanine nucleotide-exchange protein 2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)brefeldin A-inhibited GEP 2probable tubulin polyglutamylase TTLL9tubulin tyrosine ligase-like family, member 9tubulin--tyrosine ligase-like protein 9
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000371917, ENST00000493140, 
Fusion gene scores* DoF score15 X 13 X 9=17555 X 8 X 6=240
# samples 157
** MAII scorelog2(15/1755*10)=-3.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/240*10)=-1.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARFGEF2 [Title/Abstract] AND TTLL9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARFGEF2(47634087)-TTLL9(30510766), # samples:3
Anticipated loss of major functional domain due to fusion event.ARFGEF2-TTLL9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFGEF2-TTLL9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFGEF2-TTLL9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFGEF2-TTLL9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARFGEF2

GO:0001881

receptor recycling

16477018

HgeneARFGEF2

GO:0035556

intracellular signal transduction

12571360


check buttonFusion gene breakpoints across ARFGEF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TTLL9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-3B-A9HZ-01AARFGEF2chr20

47634087

+TTLL9chr20

30510766

+
ChimerDB4SARCTCGA-X6-A7W8-01AARFGEF2chr20

47634087

-TTLL9chr20

30510766

+
ChimerDB4SARCTCGA-X6-A7W8-01AARFGEF2chr20

47634087

+TTLL9chr20

30510766

+


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Fusion Gene ORF analysis for ARFGEF2-TTLL9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000371917ENST00000310998ARFGEF2chr20

47634087

+TTLL9chr20

30510766

+
In-frameENST00000371917ENST00000375921ARFGEF2chr20

47634087

+TTLL9chr20

30510766

+
In-frameENST00000371917ENST00000375922ARFGEF2chr20

47634087

+TTLL9chr20

30510766

+
In-frameENST00000371917ENST00000375934ARFGEF2chr20

47634087

+TTLL9chr20

30510766

+
In-frameENST00000371917ENST00000375938ARFGEF2chr20

47634087

+TTLL9chr20

30510766

+
In-frameENST00000371917ENST00000535842ARFGEF2chr20

47634087

+TTLL9chr20

30510766

+
intron-3CDSENST00000493140ENST00000310998ARFGEF2chr20

47634087

+TTLL9chr20

30510766

+
intron-3CDSENST00000493140ENST00000375921ARFGEF2chr20

47634087

+TTLL9chr20

30510766

+
intron-3CDSENST00000493140ENST00000375922ARFGEF2chr20

47634087

+TTLL9chr20

30510766

+
intron-3CDSENST00000493140ENST00000375934ARFGEF2chr20

47634087

+TTLL9chr20

30510766

+
intron-3CDSENST00000493140ENST00000375938ARFGEF2chr20

47634087

+TTLL9chr20

30510766

+
intron-3CDSENST00000493140ENST00000535842ARFGEF2chr20

47634087

+TTLL9chr20

30510766

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371917ARFGEF2chr2047634087+ENST00000310998TTLL9chr2030510766+51304509051291709
ENST00000371917ARFGEF2chr2047634087+ENST00000535842TTLL9chr2030510766+52904509052551751
ENST00000371917ARFGEF2chr2047634087+ENST00000375921TTLL9chr2030510766+61544509048471615
ENST00000371917ARFGEF2chr2047634087+ENST00000375938TTLL9chr2030510766+63064509052551751
ENST00000371917ARFGEF2chr2047634087+ENST00000375934TTLL9chr2030510766+51994509048291609
ENST00000371917ARFGEF2chr2047634087+ENST00000375922TTLL9chr2030510766+55634509052221740

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371917ENST00000310998ARFGEF2chr2047634087+TTLL9chr2030510766+0.0020938420.9979062
ENST00000371917ENST00000535842ARFGEF2chr2047634087+TTLL9chr2030510766+0.0012024690.99879754
ENST00000371917ENST00000375921ARFGEF2chr2047634087+TTLL9chr2030510766+0.0013746840.9986253
ENST00000371917ENST00000375938ARFGEF2chr2047634087+TTLL9chr2030510766+0.0008141460.99918586
ENST00000371917ENST00000375934ARFGEF2chr2047634087+TTLL9chr2030510766+0.001378950.9986211
ENST00000371917ENST00000375922ARFGEF2chr2047634087+TTLL9chr2030510766+0.002052140.9979479

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Fusion Genomic Features for ARFGEF2-TTLL9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARFGEF2chr2047634087+TTLL9chr2030510765+1.83E-050.99998176
ARFGEF2chr2047634087+TTLL9chr2030510765+1.83E-050.99998176
ARFGEF2chr2047634087+TTLL9chr2030510765+1.83E-050.99998176
ARFGEF2chr2047634087+TTLL9chr2030510765+1.83E-050.99998176

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARFGEF2-TTLL9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:47634087/chr20:30510766)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARFGEF2chr20:47634087chr20:30510766ENST00000371917+3339654_78515031786.0DomainSEC7
TgeneTTLL9chr20:47634087chr20:30510766ENST00000310998614211_214141348.0Nucleotide bindingATP binding
TgeneTTLL9chr20:47634087chr20:30510766ENST00000375921515211_214118495.3333333333333Nucleotide bindingATP binding
TgeneTTLL9chr20:47634087chr20:30510766ENST00000375938617211_214191671.3333333333334Nucleotide bindingATP binding
TgeneTTLL9chr20:47634087chr20:30510766ENST00000535842615211_214191440.0Nucleotide bindingATP binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTTLL9chr20:47634087chr20:30510766ENST0000031099861440_380141348.0DomainTTL
TgeneTTLL9chr20:47634087chr20:30510766ENST0000037592151540_380118495.3333333333333DomainTTL
TgeneTTLL9chr20:47634087chr20:30510766ENST0000037593861740_380191671.3333333333334DomainTTL
TgeneTTLL9chr20:47634087chr20:30510766ENST0000053584261540_380191440.0DomainTTL


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Fusion Gene Sequence for ARFGEF2-TTLL9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5879_5879_1_ARFGEF2-TTLL9_ARFGEF2_chr20_47634087_ENST00000371917_TTLL9_chr20_30510766_ENST00000310998_length(transcript)=5130nt_BP=4509nt
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC
CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGATGAAATTAAAGCAGAAATAGAAAAGCAGAGGCTTGGCACTGCTGCACCACCAAAGGCA
AACTTCATTGAAGCTGACAAGTATTTTCTTCCATTCGAGCTAGCTTGCCAGTCCAAGTCCCCAAGGGTAGTCAGCACATCCCTTGACTGC
TTGCAGAAACTCATCGCATACGGGCACATCACTGGCAACGCCCCTGACAGTGGAGCCCCTGGGAAGCGGCTGATCGACAGAATTGTTGAA
ACCATTTGCAGTTGTTTTCAGGGCCCTCAGACTGATGAAGGGGTTCAGTTACAAATAATTAAGGCTCTTCTGACTGCAGTGACTTCCCCA
CACATTGAAATTCATGAGGGTACTATCCTGCAGACAGTGAGAACATGTTACAATATCTATTTGGCCAGCAAAAATCTCATCAATCAAACC
ACTGCCAAGGCTACCCTTACTCAGATGCTGAACGTCATTTTCACCCGCATGGAAAACCAAGTGTTGCAGGAGGCCAGAGAACTGGAAAAA
CCAATCCAGTCAAAACCCCAGTCCCCTGTGATCCAAGCTGCAGCAGTATCCCCAAAGTTCGTTCGTTTGAAGCACAGTCAGGCACAAAGC
AAACCAACAACTCCCGAAAAAACAGATTTAACCAACGGTGAACATGCCAGGAGTGATTCTGGAAAAGTAAGCACAGAAAATGGAGACGCA
CCCAGAGAAAGAGGCTCATCACTGTCAGGGACTGATGACGGAGCCCAGGAGGTGGTGAAGGACATCTTGGAAGATGTAGTCACATCTGCC
ATTAAAGAAGCAGCGGAAAAGCATGGTCTGACAGAACCTGAGAGAGTTCTAGGTGAACTGGAGTGCCAGGAATGTGCTATTCCCCCAGGA
GTTGATGAAAACTCACAGACCAACGGGATAGCCGATGACAGGCAGTCCTTGTCGTCAGCAGATAATCTGGAATCGGATGCACAAGGACAT
CAAGTGGCTGCCAGGTTCTCCCACGTTCTGCAGAAGGATGCCTTCCTTGTGTTCCGCTCCCTGTGCAAGCTGTCCATGAAACCCCTTGGT
GAAGGCCCTCCAGACCCAAAATCCCATGAGCTGCGTTCCAAGGTGGTTTCCCTGCAGCTGCTCCTCTCTGTGTTGCAAAATGCTGGCCCC
GTATTCAGGACTCACGAGATGTTCATCAATGCAATCAAGCAATATCTCTGTGTGGCCTTGTCCAAAAACGGCGTCTCTTCAGTGCCTGAT
GTCTTTGAGCTCTCTCTTGCCATTTTTCTTACTCTTCTTTCAAACTTTAAAATGCACTTGAAAATGCAGATAGAGGTCTTTTTCAAAGAG
ATTTTCCTGAACATTTTAGAAACATCAACAAGTTCTTTTGAGCACAGGTGGATGGTCATTCAGACTCTGACGAGGATCTGTGCAGATGCC
CAGTGTGTTGTGGATATTTATGTCAACTACGACTGTGATTTAAATGCTGCTAACATTTTTGAGCGCCTTGTAAATGATTTATCCAAAATT
GCTCAGGGAAGAAGTGGACATGAGCTGGGAATGACACCTCTGCAGGAGCTCAGCCTGAGGAAGAAAGGCCTGGAGTGCCTCGTGTCCATT
CTCAAGTGCATGGTGGAGTGGAGCAAAGACCTGTATGTGAATCCCAACCACCAGACCAGCCTCGGTCAGGAGAGGCTCACGGATCAGGAA
ATAGGGGATGGGAAAGGCCTTGACATGGCAAGACGGTGTAGTGTGACGTCCATGGAGTCCACAGTGTCCTCGGGGACCCAGACAACTGTT
CAGGATGACCCTGAGCAATTTGAGGTCATCAAGCAACAAAAAGAAATCATTGAACACGGCATCGAGCTGTTCAACAAGAAACCCAAGAGG
GGGATCCAGTTTCTCCAGGAGCAGGGCATGCTGGGAACGTCAGTTGAAGACATAGCCCAATTCCTGCACCAGGAGGAGCGCCTGGATTCC
ACCCAAGTAGGCGATTTTCTGGGAGATAGCGCAAGGTTCAACAAGGAGGTGATGTATGCCTACGTGGACCAACTTGACTTCTGTGAAAAA
GAATTTGTCTCAGCCCTGCGGACATTCCTAGAAGGTTTCCGCCTACCTGGAGAAGCCCAAAAGATTGACCGATTAATGGAGAAGTTTGCC
GCAAGATACATAGAATGCAACCAAGGGCAAACTCTGTTTGCTAGTGCTGACACTGCTTATGTCCTAGCGTATTCAATTATTATGCTGACT
ACAGACTTGCACAGTCCTCAGGTAAAAAATAAAATGACGAAAGAGCAGTATATTAAAATGAATCGGGGTATCAATGATAGTAAAGATCTG
CCAGAAGAGTATCTCTCAAGCATCTATGAAGAGATAGAAGGCAAGAAAATTGCAATGAAAGAAACAAAAGAGCTAACGATTGCAACCAAA
TCTACTAAGCAGAATGTAGCTAGTGAAAAGCAGCGGCGGCTGCTGTACAACTTAGAGATGGAGCAAATGGCTAAAACAGCCAAAGCTCTG
ATGGAGGCTGTGAGCCATGCCAAAGCCCCGTTTACCAGTGCCACTCACCTGGACCATGTCCGGCCAATGTTCAAACTGGTGTGGACGCCA
CTATTGGCAGCCTACAGCATCGGACTCCAGAACTGTGATGACACTGAAGTGGCCTCCTTGTGTTTGGAAGGCATCCGATGTGCAATCCGA
ATCGCCTGCATCTTTGGAATGCAGCTGGAACGAGATGCCTATGTTCAGGCTCTTGCTCGCTTCTCCCTACTCACAGCCAGCTCCAGCATC
ACAGAAATGAAGCAGAAAAACATCGACACCATTAAGACGCTTATCACAGTGGCTCACACCGATGGCAACTACCTTGGGAATTCCTGGCAT
GAGATCTTGAAATGCATCAGCCAGCTGGAGCTCGCTCAGCTGATAGGAACCGGTGTGAAGACGCGCTACCTGTCTGGATCTGGGCGTGAA
AGAGAAGGGAGCCTGAAGGGCCACACATTGGCAGGAGAAGAGTTCATGGGCCTTGGCCTCGGTAATTTGGTGAGTGGCGGAGTGGATAAA
AGACAGATGGCCAGCTTCCAAGAATCGGTTGGTGAGACCAGCTCGCAGAGTGTGGTTGTAGCTGTGGACAGGATTTTTACTGGGTCTACC
AGACTGGATGGAAATGCAATAGTTGACTTTGTCCGCTGGCTGTGTGCTGTGTCCATGGATGAACTGGCTTCCCCCCACCATCCTCGCATG
TTCAGCTTGCAGAAGATTGTGGAGATATCATACTACAACATGAATCGGATCCGACTACAGTGGTCTCGAATATGGCATGTGATTGGAGAT
CACTTCAATAAGGTTGGCTGCAACCCTAATGAAGATGTGGCTATCTTTGCTGTTGACTCATTAAGGCAACTCTCCATGAAGTTTCTTGAG
AAGGGTGAATTAGCCAACTTCCGTTTCCAGAAAGATTTTCTGAGGCCCTTTGAGCATATTATGAAGAAAAACAGGTCTCCCACCATCCGG
GACATGGCGATCCGCTGCATTGCCCAGATGGTGAACTCCCAGGCGGCCAACATCCGCTCAGGTTGGAAGAACATCTTTGCCGTGTTCCAC
CAGGCAGCCTCTGATCATGATGGGAACATTGTGGAGCTGGCCTTCCAGACCACTTGCCACATTGTCACAACTATTTTCCAGCACCATTTT
CCTGCAGCCATCGATTCCTTTCAGGATGCTGTGAAGTGCTTATCAGAGTTCGCCTGCAACGCCGCTTTCCCTGACACGAGCATGGAAGCG
ATTCGGCTCATCCGCTTCTGTGGCAAATACGTCTCTGAGAGGCCTCGGGTGCTACAAGAATACACAAGTGATGACATGAATGTAGCTCCT
GGTGACAGAGTCTGGGTCCGAGGCTGGTTCCCCATCTTATTCGAACTCTCCTGCATCATTAATAGATGCAAGTTAGATGTACGAACAAGG
GGACTCACAGTCATGTTTGAGATCATGAAGAGCTATGGCCACACCTTTGAAAAGCACTGGTGGCAGGACCTGTTCAGAATCGTGTTTCGG
ATTTTTGACAATATGAAACTCCCTGAGCAACTGTCAGAGAAATCTGAGTGGATGACAACAACCTGCAATCACGCACTTTATGCTATTTGT
GATGTTTTTACCCAGTTTTATGAAGCTTTGAATGAAGTTCTTCTTTCTGATGTATTTGCACAATTGCAGTGGTGTGTCAAACAAGATAAT
GAACAGTTGGCGCGATCAGGTACAAATTGCTTAGAAAACTTAGTAATATCCAATGGAGAGAAATTCAGTCCTGAAGTCTGGGATGAAACC
TGCAACTGTATGTTGGATATTTTCAAAACAACCATCCCACATGTTTTGCTGACATGGAGACCTGTAGGAATGGAGGAAGATTCATCAGAA
AAGCATTTGGACACAAGAAGCTCTGACGACCAGAAAGATGATATTCCCGTGGAGAACTATGTGGCTCAGCGTTACATTGAAAATCCTTAC
CTGATAGGAGGCCGCAAGTTTGACCTGCGTGTCTATGTGCTGGTGATGTCGTACATCCCGCTGCGGGCCTGGCTCTACCGGGATGGCTTT
GCCCGATTCTCCAACACCCGCTTCACACTGAACAGCATTGATGACCAGTATGTTCACCTCACCAACGTGGCTGTGCAAAAAACATCTCCC
GACTACCACCCAAAGAAGGGCTGCAAGTGGACGCTGCAGCGCTTCCGGCAGTACCTGGCGTCCAAACACGGGCCCGAGGCAGTGGAGACA
CTCTTCAGGGACATCGACAACATCTTTGTCAAAAGCCTGCAGAGTGTGCAGAAGGTGATCATCAGTGACAAGCACTGCTTCGAGCTGTAC
GGCTATGACATCCTCATCGACCAGGACCTCAAGCCGTGGCTCCTGGAGGTCAATGCGTCCCCATCACTGACAGCCAGCAGCCAGGAAGAC
TATGAGCTCAAGACCTGCCTCCTGGAAGACACCCTGCATGTTGTGGACATGGAAGCGAGAAGTTTGAGGGCTGATTCTCCTTGCTGGTAA


>5879_5879_1_ARFGEF2-TTLL9_ARFGEF2_chr20_47634087_ENST00000371917_TTLL9_chr20_30510766_ENST00000310998_length(amino acids)=1709AA_BP=1503
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDC
LQKLIAYGHITGNAPDSGAPGKRLIDRIVETICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQT
TAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDLTNGEHARSDSGKVSTENGDA
PRERGSSLSGTDDGAQEVVKDILEDVVTSAIKEAAEKHGLTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLSSADNLESDAQGH
QVAARFSHVLQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSVPD
VFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKI
AQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQEIGDGKGLDMARRCSVTSMESTVSSGTQTTV
QDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEK
EFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDL
PEEYLSSIYEEIEGKKIAMKETKELTIATKSTKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTP
LLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWH
EILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGST
RLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLE
KGELANFRFQKDFLRPFEHIMKKNRSPTIRDMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHF
PAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTR
GLTVMFEIMKSYGHTFEKHWWQDLFRIVFRIFDNMKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDN
EQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSEKHLDTRSSDDQKDDIPVENYVAQRYIENPY
LIGGRKFDLRVYVLVMSYIPLRAWLYRDGFARFSNTRFTLNSIDDQYVHLTNVAVQKTSPDYHPKKGCKWTLQRFRQYLASKHGPEAVET
LFRDIDNIFVKSLQSVQKVIISDKHCFELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYELKTCLLEDTLHVVDMEARSLRADSPCW

--------------------------------------------------------------
>5879_5879_2_ARFGEF2-TTLL9_ARFGEF2_chr20_47634087_ENST00000371917_TTLL9_chr20_30510766_ENST00000375921_length(transcript)=6154nt_BP=4509nt
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC
CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGATGAAATTAAAGCAGAAATAGAAAAGCAGAGGCTTGGCACTGCTGCACCACCAAAGGCA
AACTTCATTGAAGCTGACAAGTATTTTCTTCCATTCGAGCTAGCTTGCCAGTCCAAGTCCCCAAGGGTAGTCAGCACATCCCTTGACTGC
TTGCAGAAACTCATCGCATACGGGCACATCACTGGCAACGCCCCTGACAGTGGAGCCCCTGGGAAGCGGCTGATCGACAGAATTGTTGAA
ACCATTTGCAGTTGTTTTCAGGGCCCTCAGACTGATGAAGGGGTTCAGTTACAAATAATTAAGGCTCTTCTGACTGCAGTGACTTCCCCA
CACATTGAAATTCATGAGGGTACTATCCTGCAGACAGTGAGAACATGTTACAATATCTATTTGGCCAGCAAAAATCTCATCAATCAAACC
ACTGCCAAGGCTACCCTTACTCAGATGCTGAACGTCATTTTCACCCGCATGGAAAACCAAGTGTTGCAGGAGGCCAGAGAACTGGAAAAA
CCAATCCAGTCAAAACCCCAGTCCCCTGTGATCCAAGCTGCAGCAGTATCCCCAAAGTTCGTTCGTTTGAAGCACAGTCAGGCACAAAGC
AAACCAACAACTCCCGAAAAAACAGATTTAACCAACGGTGAACATGCCAGGAGTGATTCTGGAAAAGTAAGCACAGAAAATGGAGACGCA
CCCAGAGAAAGAGGCTCATCACTGTCAGGGACTGATGACGGAGCCCAGGAGGTGGTGAAGGACATCTTGGAAGATGTAGTCACATCTGCC
ATTAAAGAAGCAGCGGAAAAGCATGGTCTGACAGAACCTGAGAGAGTTCTAGGTGAACTGGAGTGCCAGGAATGTGCTATTCCCCCAGGA
GTTGATGAAAACTCACAGACCAACGGGATAGCCGATGACAGGCAGTCCTTGTCGTCAGCAGATAATCTGGAATCGGATGCACAAGGACAT
CAAGTGGCTGCCAGGTTCTCCCACGTTCTGCAGAAGGATGCCTTCCTTGTGTTCCGCTCCCTGTGCAAGCTGTCCATGAAACCCCTTGGT
GAAGGCCCTCCAGACCCAAAATCCCATGAGCTGCGTTCCAAGGTGGTTTCCCTGCAGCTGCTCCTCTCTGTGTTGCAAAATGCTGGCCCC
GTATTCAGGACTCACGAGATGTTCATCAATGCAATCAAGCAATATCTCTGTGTGGCCTTGTCCAAAAACGGCGTCTCTTCAGTGCCTGAT
GTCTTTGAGCTCTCTCTTGCCATTTTTCTTACTCTTCTTTCAAACTTTAAAATGCACTTGAAAATGCAGATAGAGGTCTTTTTCAAAGAG
ATTTTCCTGAACATTTTAGAAACATCAACAAGTTCTTTTGAGCACAGGTGGATGGTCATTCAGACTCTGACGAGGATCTGTGCAGATGCC
CAGTGTGTTGTGGATATTTATGTCAACTACGACTGTGATTTAAATGCTGCTAACATTTTTGAGCGCCTTGTAAATGATTTATCCAAAATT
GCTCAGGGAAGAAGTGGACATGAGCTGGGAATGACACCTCTGCAGGAGCTCAGCCTGAGGAAGAAAGGCCTGGAGTGCCTCGTGTCCATT
CTCAAGTGCATGGTGGAGTGGAGCAAAGACCTGTATGTGAATCCCAACCACCAGACCAGCCTCGGTCAGGAGAGGCTCACGGATCAGGAA
ATAGGGGATGGGAAAGGCCTTGACATGGCAAGACGGTGTAGTGTGACGTCCATGGAGTCCACAGTGTCCTCGGGGACCCAGACAACTGTT
CAGGATGACCCTGAGCAATTTGAGGTCATCAAGCAACAAAAAGAAATCATTGAACACGGCATCGAGCTGTTCAACAAGAAACCCAAGAGG
GGGATCCAGTTTCTCCAGGAGCAGGGCATGCTGGGAACGTCAGTTGAAGACATAGCCCAATTCCTGCACCAGGAGGAGCGCCTGGATTCC
ACCCAAGTAGGCGATTTTCTGGGAGATAGCGCAAGGTTCAACAAGGAGGTGATGTATGCCTACGTGGACCAACTTGACTTCTGTGAAAAA
GAATTTGTCTCAGCCCTGCGGACATTCCTAGAAGGTTTCCGCCTACCTGGAGAAGCCCAAAAGATTGACCGATTAATGGAGAAGTTTGCC
GCAAGATACATAGAATGCAACCAAGGGCAAACTCTGTTTGCTAGTGCTGACACTGCTTATGTCCTAGCGTATTCAATTATTATGCTGACT
ACAGACTTGCACAGTCCTCAGGTAAAAAATAAAATGACGAAAGAGCAGTATATTAAAATGAATCGGGGTATCAATGATAGTAAAGATCTG
CCAGAAGAGTATCTCTCAAGCATCTATGAAGAGATAGAAGGCAAGAAAATTGCAATGAAAGAAACAAAAGAGCTAACGATTGCAACCAAA
TCTACTAAGCAGAATGTAGCTAGTGAAAAGCAGCGGCGGCTGCTGTACAACTTAGAGATGGAGCAAATGGCTAAAACAGCCAAAGCTCTG
ATGGAGGCTGTGAGCCATGCCAAAGCCCCGTTTACCAGTGCCACTCACCTGGACCATGTCCGGCCAATGTTCAAACTGGTGTGGACGCCA
CTATTGGCAGCCTACAGCATCGGACTCCAGAACTGTGATGACACTGAAGTGGCCTCCTTGTGTTTGGAAGGCATCCGATGTGCAATCCGA
ATCGCCTGCATCTTTGGAATGCAGCTGGAACGAGATGCCTATGTTCAGGCTCTTGCTCGCTTCTCCCTACTCACAGCCAGCTCCAGCATC
ACAGAAATGAAGCAGAAAAACATCGACACCATTAAGACGCTTATCACAGTGGCTCACACCGATGGCAACTACCTTGGGAATTCCTGGCAT
GAGATCTTGAAATGCATCAGCCAGCTGGAGCTCGCTCAGCTGATAGGAACCGGTGTGAAGACGCGCTACCTGTCTGGATCTGGGCGTGAA
AGAGAAGGGAGCCTGAAGGGCCACACATTGGCAGGAGAAGAGTTCATGGGCCTTGGCCTCGGTAATTTGGTGAGTGGCGGAGTGGATAAA
AGACAGATGGCCAGCTTCCAAGAATCGGTTGGTGAGACCAGCTCGCAGAGTGTGGTTGTAGCTGTGGACAGGATTTTTACTGGGTCTACC
AGACTGGATGGAAATGCAATAGTTGACTTTGTCCGCTGGCTGTGTGCTGTGTCCATGGATGAACTGGCTTCCCCCCACCATCCTCGCATG
TTCAGCTTGCAGAAGATTGTGGAGATATCATACTACAACATGAATCGGATCCGACTACAGTGGTCTCGAATATGGCATGTGATTGGAGAT
CACTTCAATAAGGTTGGCTGCAACCCTAATGAAGATGTGGCTATCTTTGCTGTTGACTCATTAAGGCAACTCTCCATGAAGTTTCTTGAG
AAGGGTGAATTAGCCAACTTCCGTTTCCAGAAAGATTTTCTGAGGCCCTTTGAGCATATTATGAAGAAAAACAGGTCTCCCACCATCCGG
GACATGGCGATCCGCTGCATTGCCCAGATGGTGAACTCCCAGGCGGCCAACATCCGCTCAGGTTGGAAGAACATCTTTGCCGTGTTCCAC
CAGGCAGCCTCTGATCATGATGGGAACATTGTGGAGCTGGCCTTCCAGACCACTTGCCACATTGTCACAACTATTTTCCAGCACCATTTT
CCTGCAGCCATCGATTCCTTTCAGGATGCTGTGAAGTGCTTATCAGAGTTCGCCTGCAACGCCGCTTTCCCTGACACGAGCATGGAAGCG
ATTCGGCTCATCCGCTTCTGTGGCAAATACGTCTCTGAGAGGCCTCGGGTGCTACAAGAATACACAAGTGATGACATGAATGTAGCTCCT
GGTGACAGAGTCTGGGTCCGAGGCTGGTTCCCCATCTTATTCGAACTCTCCTGCATCATTAATAGATGCAAGTTAGATGTACGAACAAGG
GGACTCACAGTCATGTTTGAGATCATGAAGAGCTATGGCCACACCTTTGAAAAGCACTGGTGGCAGGACCTGTTCAGAATCGTGTTTCGG
ATTTTTGACAATATGAAACTCCCTGAGCAACTGTCAGAGAAATCTGAGTGGATGACAACAACCTGCAATCACGCACTTTATGCTATTTGT
GATGTTTTTACCCAGTTTTATGAAGCTTTGAATGAAGTTCTTCTTTCTGATGTATTTGCACAATTGCAGTGGTGTGTCAAACAAGATAAT
GAACAGTTGGCGCGATCAGGTACAAATTGCTTAGAAAACTTAGTAATATCCAATGGAGAGAAATTCAGTCCTGAAGTCTGGGATGAAACC
TGCAACTGTATGTTGGATATTTTCAAAACAACCATCCCACATGTTTTGCTGACATGGAGACCTGTAGGAATGGAGGAAGATTCATCAGAA
AAGCATTTGGACACAAGAAGCTCTGACGACCAGAAAGATGATATTCCCGTGGAGAACTATGTGGCTCAGCGTTACATTGAAAATCCTTAC
CTGATAGGAGGCCGCAAGTTTGACCTGCGTGTCTATGTGCTGGTGATGTCGTACATCCCGCTGCGGGCCTGGCTCTACCGGGATGGCTTT
GCCCGATTCTCCAACACCCGCTTCACACTGAACAGCATTGATGACCAGTATGTTCACCTCACCAACGTGGCTGTGCAAAAAACATCTCCC
GACTACCACCCAAAGAAGGTGGCTCCTGGAGGTCAATGCGTCCCCATCACTGACAGCCAGCAGCCAGGAAGACTATGAGCTCAAGACCTG
CCTCCTGGAAGACACCCTGCATGTTGTGGACATGGAAGCGAGGCTCACGGGAAGGGAGAAGCGAGTCGGGGGCTTTGACCTCATGTGGAA
TGATGGCCCTGTTAGCAGAGAGGAGGGGGCTCCTGACCTGTCGGGAATGGGAAACTTTGTGACCAACACACATCTCGGCTGCGTCAACGA
TCGGAAGAAACAACTGAGGCAGCTCTTCTGCTCCCTTCAAGTTCAGAAGAAAGCTTCCAGTTGATCCCCAGCTGCCAGGAGGAAATCAGC
CTTAGCAGGCCTTGTGTTTGAGATTGGGAGCTGAGCCAGAAACCGGAAAACCCTGGGCTCATGGGCAGGACAGCTTCGGGAGTTGAGTGT
CAAGCCCGAAGGGAAGACTTTTGGAAGGAAAATACTGGCAAATCCAAGAAGTGAACCAGCCGACTTTAGGAAAGCCAGAAGCCAGGCTAC
TCTAGACCTTCTGCCTTCAGAGCATGAGGACTTCTCCCACTCATCCCTGTACCTGAGGCACACCAACCCAGACAGGTCCAGGCATGGACT
CCAGGTTCCCTATTTCCAGAAGGAATGCGATTAGCTTTTTTTGGCCCAGCACCCACCCTGCCAGGGAGGAAGGGGCAATTTTCCAGTGAT
GAAATTGTGAATCAGGCAGTCACACTGGACAACATCTAGCAAGGTGAATTCTGCAACTCCCTACTTTATTTACATTTTAAAATAAGCAAT
ATATTCATACGGTTTAAAATCCAAAGTTTACAAAAGGGTATAGGGTGACATCTCCTTCCCTCCCACCTGTGCGCCCCAACCCTGCAGGTG
CTGTTCTGAGGGAATCACACTGTGCTTGCACAAAAATTATTAGCTTATAAGACACCAGCCTTCCCCTTGCTTTCCTCACTTGATGTATCT
TGGAGCTTGTTCCTTATTCTTGATTATAGTTGTATGGTATTGCACTATCTGGAGCTAACACCTGTGACCCACACTCATGTTTTAAAAGTT
TCTGCATTAGTCAAAAATATTTAAAAGGAGATTCAACTTCACAACCCATATGTCTAGCTTCTCTTGAAAACACGTAAGAACTGGCCATGA
CAGCCTGTGTTTCTATGTAACTATGAGCCAGAGCCAAGGAGCGGGGGGACCAGGAGAGGTGTGCCCCTGCCATGCTGCCATTTGTTATCA
CCCGCCTGTCAAATCACAGGTTTATTTCAAGGCAAGAACCATGTTCATAGGTTGTATTCTAAATGGAGTGGCGTGCCCTTACTGAAGGAC
TAGATGAGGCAAATAAAGACTAGTTGCTGCTATT

>5879_5879_2_ARFGEF2-TTLL9_ARFGEF2_chr20_47634087_ENST00000371917_TTLL9_chr20_30510766_ENST00000375921_length(amino acids)=1615AA_BP=1503
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDC
LQKLIAYGHITGNAPDSGAPGKRLIDRIVETICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQT
TAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDLTNGEHARSDSGKVSTENGDA
PRERGSSLSGTDDGAQEVVKDILEDVVTSAIKEAAEKHGLTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLSSADNLESDAQGH
QVAARFSHVLQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSVPD
VFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKI
AQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQEIGDGKGLDMARRCSVTSMESTVSSGTQTTV
QDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEK
EFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDL
PEEYLSSIYEEIEGKKIAMKETKELTIATKSTKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTP
LLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWH
EILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGST
RLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLE
KGELANFRFQKDFLRPFEHIMKKNRSPTIRDMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHF
PAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTR
GLTVMFEIMKSYGHTFEKHWWQDLFRIVFRIFDNMKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDN
EQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSEKHLDTRSSDDQKDDIPVENYVAQRYIENPY
LIGGRKFDLRVYVLVMSYIPLRAWLYRDGFARFSNTRFTLNSIDDQYVHLTNVAVQKTSPDYHPKKVAPGGQCVPITDSQQPGRL

--------------------------------------------------------------
>5879_5879_3_ARFGEF2-TTLL9_ARFGEF2_chr20_47634087_ENST00000371917_TTLL9_chr20_30510766_ENST00000375922_length(transcript)=5563nt_BP=4509nt
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC
CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGATGAAATTAAAGCAGAAATAGAAAAGCAGAGGCTTGGCACTGCTGCACCACCAAAGGCA
AACTTCATTGAAGCTGACAAGTATTTTCTTCCATTCGAGCTAGCTTGCCAGTCCAAGTCCCCAAGGGTAGTCAGCACATCCCTTGACTGC
TTGCAGAAACTCATCGCATACGGGCACATCACTGGCAACGCCCCTGACAGTGGAGCCCCTGGGAAGCGGCTGATCGACAGAATTGTTGAA
ACCATTTGCAGTTGTTTTCAGGGCCCTCAGACTGATGAAGGGGTTCAGTTACAAATAATTAAGGCTCTTCTGACTGCAGTGACTTCCCCA
CACATTGAAATTCATGAGGGTACTATCCTGCAGACAGTGAGAACATGTTACAATATCTATTTGGCCAGCAAAAATCTCATCAATCAAACC
ACTGCCAAGGCTACCCTTACTCAGATGCTGAACGTCATTTTCACCCGCATGGAAAACCAAGTGTTGCAGGAGGCCAGAGAACTGGAAAAA
CCAATCCAGTCAAAACCCCAGTCCCCTGTGATCCAAGCTGCAGCAGTATCCCCAAAGTTCGTTCGTTTGAAGCACAGTCAGGCACAAAGC
AAACCAACAACTCCCGAAAAAACAGATTTAACCAACGGTGAACATGCCAGGAGTGATTCTGGAAAAGTAAGCACAGAAAATGGAGACGCA
CCCAGAGAAAGAGGCTCATCACTGTCAGGGACTGATGACGGAGCCCAGGAGGTGGTGAAGGACATCTTGGAAGATGTAGTCACATCTGCC
ATTAAAGAAGCAGCGGAAAAGCATGGTCTGACAGAACCTGAGAGAGTTCTAGGTGAACTGGAGTGCCAGGAATGTGCTATTCCCCCAGGA
GTTGATGAAAACTCACAGACCAACGGGATAGCCGATGACAGGCAGTCCTTGTCGTCAGCAGATAATCTGGAATCGGATGCACAAGGACAT
CAAGTGGCTGCCAGGTTCTCCCACGTTCTGCAGAAGGATGCCTTCCTTGTGTTCCGCTCCCTGTGCAAGCTGTCCATGAAACCCCTTGGT
GAAGGCCCTCCAGACCCAAAATCCCATGAGCTGCGTTCCAAGGTGGTTTCCCTGCAGCTGCTCCTCTCTGTGTTGCAAAATGCTGGCCCC
GTATTCAGGACTCACGAGATGTTCATCAATGCAATCAAGCAATATCTCTGTGTGGCCTTGTCCAAAAACGGCGTCTCTTCAGTGCCTGAT
GTCTTTGAGCTCTCTCTTGCCATTTTTCTTACTCTTCTTTCAAACTTTAAAATGCACTTGAAAATGCAGATAGAGGTCTTTTTCAAAGAG
ATTTTCCTGAACATTTTAGAAACATCAACAAGTTCTTTTGAGCACAGGTGGATGGTCATTCAGACTCTGACGAGGATCTGTGCAGATGCC
CAGTGTGTTGTGGATATTTATGTCAACTACGACTGTGATTTAAATGCTGCTAACATTTTTGAGCGCCTTGTAAATGATTTATCCAAAATT
GCTCAGGGAAGAAGTGGACATGAGCTGGGAATGACACCTCTGCAGGAGCTCAGCCTGAGGAAGAAAGGCCTGGAGTGCCTCGTGTCCATT
CTCAAGTGCATGGTGGAGTGGAGCAAAGACCTGTATGTGAATCCCAACCACCAGACCAGCCTCGGTCAGGAGAGGCTCACGGATCAGGAA
ATAGGGGATGGGAAAGGCCTTGACATGGCAAGACGGTGTAGTGTGACGTCCATGGAGTCCACAGTGTCCTCGGGGACCCAGACAACTGTT
CAGGATGACCCTGAGCAATTTGAGGTCATCAAGCAACAAAAAGAAATCATTGAACACGGCATCGAGCTGTTCAACAAGAAACCCAAGAGG
GGGATCCAGTTTCTCCAGGAGCAGGGCATGCTGGGAACGTCAGTTGAAGACATAGCCCAATTCCTGCACCAGGAGGAGCGCCTGGATTCC
ACCCAAGTAGGCGATTTTCTGGGAGATAGCGCAAGGTTCAACAAGGAGGTGATGTATGCCTACGTGGACCAACTTGACTTCTGTGAAAAA
GAATTTGTCTCAGCCCTGCGGACATTCCTAGAAGGTTTCCGCCTACCTGGAGAAGCCCAAAAGATTGACCGATTAATGGAGAAGTTTGCC
GCAAGATACATAGAATGCAACCAAGGGCAAACTCTGTTTGCTAGTGCTGACACTGCTTATGTCCTAGCGTATTCAATTATTATGCTGACT
ACAGACTTGCACAGTCCTCAGGTAAAAAATAAAATGACGAAAGAGCAGTATATTAAAATGAATCGGGGTATCAATGATAGTAAAGATCTG
CCAGAAGAGTATCTCTCAAGCATCTATGAAGAGATAGAAGGCAAGAAAATTGCAATGAAAGAAACAAAAGAGCTAACGATTGCAACCAAA
TCTACTAAGCAGAATGTAGCTAGTGAAAAGCAGCGGCGGCTGCTGTACAACTTAGAGATGGAGCAAATGGCTAAAACAGCCAAAGCTCTG
ATGGAGGCTGTGAGCCATGCCAAAGCCCCGTTTACCAGTGCCACTCACCTGGACCATGTCCGGCCAATGTTCAAACTGGTGTGGACGCCA
CTATTGGCAGCCTACAGCATCGGACTCCAGAACTGTGATGACACTGAAGTGGCCTCCTTGTGTTTGGAAGGCATCCGATGTGCAATCCGA
ATCGCCTGCATCTTTGGAATGCAGCTGGAACGAGATGCCTATGTTCAGGCTCTTGCTCGCTTCTCCCTACTCACAGCCAGCTCCAGCATC
ACAGAAATGAAGCAGAAAAACATCGACACCATTAAGACGCTTATCACAGTGGCTCACACCGATGGCAACTACCTTGGGAATTCCTGGCAT
GAGATCTTGAAATGCATCAGCCAGCTGGAGCTCGCTCAGCTGATAGGAACCGGTGTGAAGACGCGCTACCTGTCTGGATCTGGGCGTGAA
AGAGAAGGGAGCCTGAAGGGCCACACATTGGCAGGAGAAGAGTTCATGGGCCTTGGCCTCGGTAATTTGGTGAGTGGCGGAGTGGATAAA
AGACAGATGGCCAGCTTCCAAGAATCGGTTGGTGAGACCAGCTCGCAGAGTGTGGTTGTAGCTGTGGACAGGATTTTTACTGGGTCTACC
AGACTGGATGGAAATGCAATAGTTGACTTTGTCCGCTGGCTGTGTGCTGTGTCCATGGATGAACTGGCTTCCCCCCACCATCCTCGCATG
TTCAGCTTGCAGAAGATTGTGGAGATATCATACTACAACATGAATCGGATCCGACTACAGTGGTCTCGAATATGGCATGTGATTGGAGAT
CACTTCAATAAGGTTGGCTGCAACCCTAATGAAGATGTGGCTATCTTTGCTGTTGACTCATTAAGGCAACTCTCCATGAAGTTTCTTGAG
AAGGGTGAATTAGCCAACTTCCGTTTCCAGAAAGATTTTCTGAGGCCCTTTGAGCATATTATGAAGAAAAACAGGTCTCCCACCATCCGG
GACATGGCGATCCGCTGCATTGCCCAGATGGTGAACTCCCAGGCGGCCAACATCCGCTCAGGTTGGAAGAACATCTTTGCCGTGTTCCAC
CAGGCAGCCTCTGATCATGATGGGAACATTGTGGAGCTGGCCTTCCAGACCACTTGCCACATTGTCACAACTATTTTCCAGCACCATTTT
CCTGCAGCCATCGATTCCTTTCAGGATGCTGTGAAGTGCTTATCAGAGTTCGCCTGCAACGCCGCTTTCCCTGACACGAGCATGGAAGCG
ATTCGGCTCATCCGCTTCTGTGGCAAATACGTCTCTGAGAGGCCTCGGGTGCTACAAGAATACACAAGTGATGACATGAATGTAGCTCCT
GGTGACAGAGTCTGGGTCCGAGGCTGGTTCCCCATCTTATTCGAACTCTCCTGCATCATTAATAGATGCAAGTTAGATGTACGAACAAGG
GGACTCACAGTCATGTTTGAGATCATGAAGAGCTATGGCCACACCTTTGAAAAGCACTGGTGGCAGGACCTGTTCAGAATCGTGTTTCGG
ATTTTTGACAATATGAAACTCCCTGAGCAACTGTCAGAGAAATCTGAGTGGATGACAACAACCTGCAATCACGCACTTTATGCTATTTGT
GATGTTTTTACCCAGTTTTATGAAGCTTTGAATGAAGTTCTTCTTTCTGATGTATTTGCACAATTGCAGTGGTGTGTCAAACAAGATAAT
GAACAGTTGGCGCGATCAGGTACAAATTGCTTAGAAAACTTAGTAATATCCAATGGAGAGAAATTCAGTCCTGAAGTCTGGGATGAAACC
TGCAACTGTATGTTGGATATTTTCAAAACAACCATCCCACATGTTTTGCTGACATGGAGACCTGTAGGAATGGAGGAAGATTCATCAGAA
AAGCATTTGGACACAAGAAGCTCTGACGACCAGAAAGATGATATTCCCGTGGAGAACTATGTGGCTCAGCGTTACATTGAAAATCCTTAC
CTGATAGGAGGCCGCAAGTTTGACCTGCGTGTCTATGTGCTGGTGATGTCGTACATCCCGCTGCGGGCCTGGCTCTACCGGGATGGCTTT
GCCCGATTCTCCAACACCCGCTTCACACTGAACAGCATTGATGACCAGTATGTTCACCTCACCAACGTGGCTGTGCAAAAAACATCTCCC
GACTACCACCCAAAGAAGGGCTGCAAGTGGACGCTGCAGCGCTTCCGGCAGTACCTGGCGTCCAAACACGGGCCCGAGGCAGTGGAGACA
CTCTTCAGGGACATCGACAACATCTTTGTCAAAAGCCTGCAGAGTGTGCAGAAGGTGATCATCAGTGACAAGCACTGCTTCGAGCTGTAC
GGCTATGACATCCTCATCGACCAGGACCTCAAGCCGTGGCTCCTGGAGGTCAATGCGTCCCCATCACTGACAGCCAGCAGCCAGGAAGAC
TATGAGCTCAAGACCTGCCTCCTGGAAGACACCCTGCATGTTGTGGACATGGAAGCGAGGCTGCGTCAACGATCGGAAGAAACAACTGAG
GCAGCTCTTCTGCTCCCTTCAAGTTCAGAAGAAAGCTTCCAGTTGATCCCCAGCTGCCAGGAGGAAATCAGCCTTAGCAGGCCTTGTGTT
TGAGATTGGGAGCTGAGCCAGAAACCGGAAAACCCTGGGCTCATGGGCAGGACAGCTTCGGGAGTTGAGTGTCAAGCCCGAAGGGAAGAC
TTTTGGAAGGAAAATACTGGCAAATCCAAGAAGTGAACCAGCCGACTTTAGGAAAGCCAGAAGCCAGGCTACTCTAGACCTTCTGCCTTC
AGAGCATGAGGACTTCTCCCACTCATCCCTGTACCTGAGGCACACCAACCCAGACAGGTCCAGGCATGGACTCCAGGTTCCCTATTTCCA
GAAGGAATGCGATTAGCTTTTTTTGGCCCAGCACCCACCCTGCCAGGGAGGAAGGGGCAATTTTCCAGTGATG

>5879_5879_3_ARFGEF2-TTLL9_ARFGEF2_chr20_47634087_ENST00000371917_TTLL9_chr20_30510766_ENST00000375922_length(amino acids)=1740AA_BP=1503
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDC
LQKLIAYGHITGNAPDSGAPGKRLIDRIVETICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQT
TAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDLTNGEHARSDSGKVSTENGDA
PRERGSSLSGTDDGAQEVVKDILEDVVTSAIKEAAEKHGLTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLSSADNLESDAQGH
QVAARFSHVLQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSVPD
VFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKI
AQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQEIGDGKGLDMARRCSVTSMESTVSSGTQTTV
QDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEK
EFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDL
PEEYLSSIYEEIEGKKIAMKETKELTIATKSTKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTP
LLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWH
EILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGST
RLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLE
KGELANFRFQKDFLRPFEHIMKKNRSPTIRDMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHF
PAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTR
GLTVMFEIMKSYGHTFEKHWWQDLFRIVFRIFDNMKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDN
EQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSEKHLDTRSSDDQKDDIPVENYVAQRYIENPY
LIGGRKFDLRVYVLVMSYIPLRAWLYRDGFARFSNTRFTLNSIDDQYVHLTNVAVQKTSPDYHPKKGCKWTLQRFRQYLASKHGPEAVET
LFRDIDNIFVKSLQSVQKVIISDKHCFELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYELKTCLLEDTLHVVDMEARLRQRSEETTE
AALLLPSSSEESFQLIPSCQEEISLSRPCV

--------------------------------------------------------------
>5879_5879_4_ARFGEF2-TTLL9_ARFGEF2_chr20_47634087_ENST00000371917_TTLL9_chr20_30510766_ENST00000375934_length(transcript)=5199nt_BP=4509nt
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC
CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGATGAAATTAAAGCAGAAATAGAAAAGCAGAGGCTTGGCACTGCTGCACCACCAAAGGCA
AACTTCATTGAAGCTGACAAGTATTTTCTTCCATTCGAGCTAGCTTGCCAGTCCAAGTCCCCAAGGGTAGTCAGCACATCCCTTGACTGC
TTGCAGAAACTCATCGCATACGGGCACATCACTGGCAACGCCCCTGACAGTGGAGCCCCTGGGAAGCGGCTGATCGACAGAATTGTTGAA
ACCATTTGCAGTTGTTTTCAGGGCCCTCAGACTGATGAAGGGGTTCAGTTACAAATAATTAAGGCTCTTCTGACTGCAGTGACTTCCCCA
CACATTGAAATTCATGAGGGTACTATCCTGCAGACAGTGAGAACATGTTACAATATCTATTTGGCCAGCAAAAATCTCATCAATCAAACC
ACTGCCAAGGCTACCCTTACTCAGATGCTGAACGTCATTTTCACCCGCATGGAAAACCAAGTGTTGCAGGAGGCCAGAGAACTGGAAAAA
CCAATCCAGTCAAAACCCCAGTCCCCTGTGATCCAAGCTGCAGCAGTATCCCCAAAGTTCGTTCGTTTGAAGCACAGTCAGGCACAAAGC
AAACCAACAACTCCCGAAAAAACAGATTTAACCAACGGTGAACATGCCAGGAGTGATTCTGGAAAAGTAAGCACAGAAAATGGAGACGCA
CCCAGAGAAAGAGGCTCATCACTGTCAGGGACTGATGACGGAGCCCAGGAGGTGGTGAAGGACATCTTGGAAGATGTAGTCACATCTGCC
ATTAAAGAAGCAGCGGAAAAGCATGGTCTGACAGAACCTGAGAGAGTTCTAGGTGAACTGGAGTGCCAGGAATGTGCTATTCCCCCAGGA
GTTGATGAAAACTCACAGACCAACGGGATAGCCGATGACAGGCAGTCCTTGTCGTCAGCAGATAATCTGGAATCGGATGCACAAGGACAT
CAAGTGGCTGCCAGGTTCTCCCACGTTCTGCAGAAGGATGCCTTCCTTGTGTTCCGCTCCCTGTGCAAGCTGTCCATGAAACCCCTTGGT
GAAGGCCCTCCAGACCCAAAATCCCATGAGCTGCGTTCCAAGGTGGTTTCCCTGCAGCTGCTCCTCTCTGTGTTGCAAAATGCTGGCCCC
GTATTCAGGACTCACGAGATGTTCATCAATGCAATCAAGCAATATCTCTGTGTGGCCTTGTCCAAAAACGGCGTCTCTTCAGTGCCTGAT
GTCTTTGAGCTCTCTCTTGCCATTTTTCTTACTCTTCTTTCAAACTTTAAAATGCACTTGAAAATGCAGATAGAGGTCTTTTTCAAAGAG
ATTTTCCTGAACATTTTAGAAACATCAACAAGTTCTTTTGAGCACAGGTGGATGGTCATTCAGACTCTGACGAGGATCTGTGCAGATGCC
CAGTGTGTTGTGGATATTTATGTCAACTACGACTGTGATTTAAATGCTGCTAACATTTTTGAGCGCCTTGTAAATGATTTATCCAAAATT
GCTCAGGGAAGAAGTGGACATGAGCTGGGAATGACACCTCTGCAGGAGCTCAGCCTGAGGAAGAAAGGCCTGGAGTGCCTCGTGTCCATT
CTCAAGTGCATGGTGGAGTGGAGCAAAGACCTGTATGTGAATCCCAACCACCAGACCAGCCTCGGTCAGGAGAGGCTCACGGATCAGGAA
ATAGGGGATGGGAAAGGCCTTGACATGGCAAGACGGTGTAGTGTGACGTCCATGGAGTCCACAGTGTCCTCGGGGACCCAGACAACTGTT
CAGGATGACCCTGAGCAATTTGAGGTCATCAAGCAACAAAAAGAAATCATTGAACACGGCATCGAGCTGTTCAACAAGAAACCCAAGAGG
GGGATCCAGTTTCTCCAGGAGCAGGGCATGCTGGGAACGTCAGTTGAAGACATAGCCCAATTCCTGCACCAGGAGGAGCGCCTGGATTCC
ACCCAAGTAGGCGATTTTCTGGGAGATAGCGCAAGGTTCAACAAGGAGGTGATGTATGCCTACGTGGACCAACTTGACTTCTGTGAAAAA
GAATTTGTCTCAGCCCTGCGGACATTCCTAGAAGGTTTCCGCCTACCTGGAGAAGCCCAAAAGATTGACCGATTAATGGAGAAGTTTGCC
GCAAGATACATAGAATGCAACCAAGGGCAAACTCTGTTTGCTAGTGCTGACACTGCTTATGTCCTAGCGTATTCAATTATTATGCTGACT
ACAGACTTGCACAGTCCTCAGGTAAAAAATAAAATGACGAAAGAGCAGTATATTAAAATGAATCGGGGTATCAATGATAGTAAAGATCTG
CCAGAAGAGTATCTCTCAAGCATCTATGAAGAGATAGAAGGCAAGAAAATTGCAATGAAAGAAACAAAAGAGCTAACGATTGCAACCAAA
TCTACTAAGCAGAATGTAGCTAGTGAAAAGCAGCGGCGGCTGCTGTACAACTTAGAGATGGAGCAAATGGCTAAAACAGCCAAAGCTCTG
ATGGAGGCTGTGAGCCATGCCAAAGCCCCGTTTACCAGTGCCACTCACCTGGACCATGTCCGGCCAATGTTCAAACTGGTGTGGACGCCA
CTATTGGCAGCCTACAGCATCGGACTCCAGAACTGTGATGACACTGAAGTGGCCTCCTTGTGTTTGGAAGGCATCCGATGTGCAATCCGA
ATCGCCTGCATCTTTGGAATGCAGCTGGAACGAGATGCCTATGTTCAGGCTCTTGCTCGCTTCTCCCTACTCACAGCCAGCTCCAGCATC
ACAGAAATGAAGCAGAAAAACATCGACACCATTAAGACGCTTATCACAGTGGCTCACACCGATGGCAACTACCTTGGGAATTCCTGGCAT
GAGATCTTGAAATGCATCAGCCAGCTGGAGCTCGCTCAGCTGATAGGAACCGGTGTGAAGACGCGCTACCTGTCTGGATCTGGGCGTGAA
AGAGAAGGGAGCCTGAAGGGCCACACATTGGCAGGAGAAGAGTTCATGGGCCTTGGCCTCGGTAATTTGGTGAGTGGCGGAGTGGATAAA
AGACAGATGGCCAGCTTCCAAGAATCGGTTGGTGAGACCAGCTCGCAGAGTGTGGTTGTAGCTGTGGACAGGATTTTTACTGGGTCTACC
AGACTGGATGGAAATGCAATAGTTGACTTTGTCCGCTGGCTGTGTGCTGTGTCCATGGATGAACTGGCTTCCCCCCACCATCCTCGCATG
TTCAGCTTGCAGAAGATTGTGGAGATATCATACTACAACATGAATCGGATCCGACTACAGTGGTCTCGAATATGGCATGTGATTGGAGAT
CACTTCAATAAGGTTGGCTGCAACCCTAATGAAGATGTGGCTATCTTTGCTGTTGACTCATTAAGGCAACTCTCCATGAAGTTTCTTGAG
AAGGGTGAATTAGCCAACTTCCGTTTCCAGAAAGATTTTCTGAGGCCCTTTGAGCATATTATGAAGAAAAACAGGTCTCCCACCATCCGG
GACATGGCGATCCGCTGCATTGCCCAGATGGTGAACTCCCAGGCGGCCAACATCCGCTCAGGTTGGAAGAACATCTTTGCCGTGTTCCAC
CAGGCAGCCTCTGATCATGATGGGAACATTGTGGAGCTGGCCTTCCAGACCACTTGCCACATTGTCACAACTATTTTCCAGCACCATTTT
CCTGCAGCCATCGATTCCTTTCAGGATGCTGTGAAGTGCTTATCAGAGTTCGCCTGCAACGCCGCTTTCCCTGACACGAGCATGGAAGCG
ATTCGGCTCATCCGCTTCTGTGGCAAATACGTCTCTGAGAGGCCTCGGGTGCTACAAGAATACACAAGTGATGACATGAATGTAGCTCCT
GGTGACAGAGTCTGGGTCCGAGGCTGGTTCCCCATCTTATTCGAACTCTCCTGCATCATTAATAGATGCAAGTTAGATGTACGAACAAGG
GGACTCACAGTCATGTTTGAGATCATGAAGAGCTATGGCCACACCTTTGAAAAGCACTGGTGGCAGGACCTGTTCAGAATCGTGTTTCGG
ATTTTTGACAATATGAAACTCCCTGAGCAACTGTCAGAGAAATCTGAGTGGATGACAACAACCTGCAATCACGCACTTTATGCTATTTGT
GATGTTTTTACCCAGTTTTATGAAGCTTTGAATGAAGTTCTTCTTTCTGATGTATTTGCACAATTGCAGTGGTGTGTCAAACAAGATAAT
GAACAGTTGGCGCGATCAGGTACAAATTGCTTAGAAAACTTAGTAATATCCAATGGAGAGAAATTCAGTCCTGAAGTCTGGGATGAAACC
TGCAACTGTATGTTGGATATTTTCAAAACAACCATCCCACATGTTTTGCTGACATGGAGACCTGTAGGAATGGAGGAAGATTCATCAGAA
AAGCATTTGGACACAAGAAGCTCTGACGACCAGAAAGATGATATTCCCGTGGAGAACTATGTGGCTCAGCGTTACATTGAAAATCCTTAC
CTGATAGGAGGCCGCAAGTTTGACCTGCGTGTCTATGTGCTGGTGATGTCGATGTTCACCTCACCAACGTGGCTGTGCAAAAAACATCTC
CCGACTACCACCCAAAGAAGGGCTGCAAGTGGACGCTGCAGCGCTTCCGGCAGTACCTGGCGTCCAAACACGGGCCCGAGGCAGTGGAGA
CACTCTTCAGGGACATCGACAACATCTTTGTCAAAAGCCTGCAGAGTGTGCAGAAGGTGATCATCAGTGACAAGCACTGCTTCGAGCTGT
ACGGCTATGACATCCTCATCGACCAGGACCTCAAGCCGTGGCTCCTGGAGGTCAATGCGTCCCCATCACTGACAGCCAGCAGCCAGGAAG
ACTATGAGCTCAAGACCTGCCTCCTGGAAGACACCCTGCATGTTGTGGACATGGAAGCGAGGCTCACGGGAAGGGAGAAGCGAGTCGGGG
GCTTTGACCTCATGTGGAATGATGGCCCTGTTAGCAGAGAGGAGGGGGCTCCTGACCTGTCGGGAATGGGAAACTTTGTGACCAACACAC
ATCTCGGCTGCGTCAACGATCGGAAGAAACAACTGAGGCAGCTCTTCTGCTCCCTTCAAGTTCAGAAGA

>5879_5879_4_ARFGEF2-TTLL9_ARFGEF2_chr20_47634087_ENST00000371917_TTLL9_chr20_30510766_ENST00000375934_length(amino acids)=1609AA_BP=1503
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDC
LQKLIAYGHITGNAPDSGAPGKRLIDRIVETICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQT
TAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDLTNGEHARSDSGKVSTENGDA
PRERGSSLSGTDDGAQEVVKDILEDVVTSAIKEAAEKHGLTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLSSADNLESDAQGH
QVAARFSHVLQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSVPD
VFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKI
AQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQEIGDGKGLDMARRCSVTSMESTVSSGTQTTV
QDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEK
EFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDL
PEEYLSSIYEEIEGKKIAMKETKELTIATKSTKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTP
LLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWH
EILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGST
RLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLE
KGELANFRFQKDFLRPFEHIMKKNRSPTIRDMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHF
PAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTR
GLTVMFEIMKSYGHTFEKHWWQDLFRIVFRIFDNMKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDN
EQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSEKHLDTRSSDDQKDDIPVENYVAQRYIENPY
LIGGRKFDLRVYVLVMSMFTSPTWLCKKHLPTTTQRRAASGRCSASGSTWRPNTGPRQWRHSSGTSTTSLSKACRVCRR

--------------------------------------------------------------
>5879_5879_5_ARFGEF2-TTLL9_ARFGEF2_chr20_47634087_ENST00000371917_TTLL9_chr20_30510766_ENST00000375938_length(transcript)=6306nt_BP=4509nt
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC
CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGATGAAATTAAAGCAGAAATAGAAAAGCAGAGGCTTGGCACTGCTGCACCACCAAAGGCA
AACTTCATTGAAGCTGACAAGTATTTTCTTCCATTCGAGCTAGCTTGCCAGTCCAAGTCCCCAAGGGTAGTCAGCACATCCCTTGACTGC
TTGCAGAAACTCATCGCATACGGGCACATCACTGGCAACGCCCCTGACAGTGGAGCCCCTGGGAAGCGGCTGATCGACAGAATTGTTGAA
ACCATTTGCAGTTGTTTTCAGGGCCCTCAGACTGATGAAGGGGTTCAGTTACAAATAATTAAGGCTCTTCTGACTGCAGTGACTTCCCCA
CACATTGAAATTCATGAGGGTACTATCCTGCAGACAGTGAGAACATGTTACAATATCTATTTGGCCAGCAAAAATCTCATCAATCAAACC
ACTGCCAAGGCTACCCTTACTCAGATGCTGAACGTCATTTTCACCCGCATGGAAAACCAAGTGTTGCAGGAGGCCAGAGAACTGGAAAAA
CCAATCCAGTCAAAACCCCAGTCCCCTGTGATCCAAGCTGCAGCAGTATCCCCAAAGTTCGTTCGTTTGAAGCACAGTCAGGCACAAAGC
AAACCAACAACTCCCGAAAAAACAGATTTAACCAACGGTGAACATGCCAGGAGTGATTCTGGAAAAGTAAGCACAGAAAATGGAGACGCA
CCCAGAGAAAGAGGCTCATCACTGTCAGGGACTGATGACGGAGCCCAGGAGGTGGTGAAGGACATCTTGGAAGATGTAGTCACATCTGCC
ATTAAAGAAGCAGCGGAAAAGCATGGTCTGACAGAACCTGAGAGAGTTCTAGGTGAACTGGAGTGCCAGGAATGTGCTATTCCCCCAGGA
GTTGATGAAAACTCACAGACCAACGGGATAGCCGATGACAGGCAGTCCTTGTCGTCAGCAGATAATCTGGAATCGGATGCACAAGGACAT
CAAGTGGCTGCCAGGTTCTCCCACGTTCTGCAGAAGGATGCCTTCCTTGTGTTCCGCTCCCTGTGCAAGCTGTCCATGAAACCCCTTGGT
GAAGGCCCTCCAGACCCAAAATCCCATGAGCTGCGTTCCAAGGTGGTTTCCCTGCAGCTGCTCCTCTCTGTGTTGCAAAATGCTGGCCCC
GTATTCAGGACTCACGAGATGTTCATCAATGCAATCAAGCAATATCTCTGTGTGGCCTTGTCCAAAAACGGCGTCTCTTCAGTGCCTGAT
GTCTTTGAGCTCTCTCTTGCCATTTTTCTTACTCTTCTTTCAAACTTTAAAATGCACTTGAAAATGCAGATAGAGGTCTTTTTCAAAGAG
ATTTTCCTGAACATTTTAGAAACATCAACAAGTTCTTTTGAGCACAGGTGGATGGTCATTCAGACTCTGACGAGGATCTGTGCAGATGCC
CAGTGTGTTGTGGATATTTATGTCAACTACGACTGTGATTTAAATGCTGCTAACATTTTTGAGCGCCTTGTAAATGATTTATCCAAAATT
GCTCAGGGAAGAAGTGGACATGAGCTGGGAATGACACCTCTGCAGGAGCTCAGCCTGAGGAAGAAAGGCCTGGAGTGCCTCGTGTCCATT
CTCAAGTGCATGGTGGAGTGGAGCAAAGACCTGTATGTGAATCCCAACCACCAGACCAGCCTCGGTCAGGAGAGGCTCACGGATCAGGAA
ATAGGGGATGGGAAAGGCCTTGACATGGCAAGACGGTGTAGTGTGACGTCCATGGAGTCCACAGTGTCCTCGGGGACCCAGACAACTGTT
CAGGATGACCCTGAGCAATTTGAGGTCATCAAGCAACAAAAAGAAATCATTGAACACGGCATCGAGCTGTTCAACAAGAAACCCAAGAGG
GGGATCCAGTTTCTCCAGGAGCAGGGCATGCTGGGAACGTCAGTTGAAGACATAGCCCAATTCCTGCACCAGGAGGAGCGCCTGGATTCC
ACCCAAGTAGGCGATTTTCTGGGAGATAGCGCAAGGTTCAACAAGGAGGTGATGTATGCCTACGTGGACCAACTTGACTTCTGTGAAAAA
GAATTTGTCTCAGCCCTGCGGACATTCCTAGAAGGTTTCCGCCTACCTGGAGAAGCCCAAAAGATTGACCGATTAATGGAGAAGTTTGCC
GCAAGATACATAGAATGCAACCAAGGGCAAACTCTGTTTGCTAGTGCTGACACTGCTTATGTCCTAGCGTATTCAATTATTATGCTGACT
ACAGACTTGCACAGTCCTCAGGTAAAAAATAAAATGACGAAAGAGCAGTATATTAAAATGAATCGGGGTATCAATGATAGTAAAGATCTG
CCAGAAGAGTATCTCTCAAGCATCTATGAAGAGATAGAAGGCAAGAAAATTGCAATGAAAGAAACAAAAGAGCTAACGATTGCAACCAAA
TCTACTAAGCAGAATGTAGCTAGTGAAAAGCAGCGGCGGCTGCTGTACAACTTAGAGATGGAGCAAATGGCTAAAACAGCCAAAGCTCTG
ATGGAGGCTGTGAGCCATGCCAAAGCCCCGTTTACCAGTGCCACTCACCTGGACCATGTCCGGCCAATGTTCAAACTGGTGTGGACGCCA
CTATTGGCAGCCTACAGCATCGGACTCCAGAACTGTGATGACACTGAAGTGGCCTCCTTGTGTTTGGAAGGCATCCGATGTGCAATCCGA
ATCGCCTGCATCTTTGGAATGCAGCTGGAACGAGATGCCTATGTTCAGGCTCTTGCTCGCTTCTCCCTACTCACAGCCAGCTCCAGCATC
ACAGAAATGAAGCAGAAAAACATCGACACCATTAAGACGCTTATCACAGTGGCTCACACCGATGGCAACTACCTTGGGAATTCCTGGCAT
GAGATCTTGAAATGCATCAGCCAGCTGGAGCTCGCTCAGCTGATAGGAACCGGTGTGAAGACGCGCTACCTGTCTGGATCTGGGCGTGAA
AGAGAAGGGAGCCTGAAGGGCCACACATTGGCAGGAGAAGAGTTCATGGGCCTTGGCCTCGGTAATTTGGTGAGTGGCGGAGTGGATAAA
AGACAGATGGCCAGCTTCCAAGAATCGGTTGGTGAGACCAGCTCGCAGAGTGTGGTTGTAGCTGTGGACAGGATTTTTACTGGGTCTACC
AGACTGGATGGAAATGCAATAGTTGACTTTGTCCGCTGGCTGTGTGCTGTGTCCATGGATGAACTGGCTTCCCCCCACCATCCTCGCATG
TTCAGCTTGCAGAAGATTGTGGAGATATCATACTACAACATGAATCGGATCCGACTACAGTGGTCTCGAATATGGCATGTGATTGGAGAT
CACTTCAATAAGGTTGGCTGCAACCCTAATGAAGATGTGGCTATCTTTGCTGTTGACTCATTAAGGCAACTCTCCATGAAGTTTCTTGAG
AAGGGTGAATTAGCCAACTTCCGTTTCCAGAAAGATTTTCTGAGGCCCTTTGAGCATATTATGAAGAAAAACAGGTCTCCCACCATCCGG
GACATGGCGATCCGCTGCATTGCCCAGATGGTGAACTCCCAGGCGGCCAACATCCGCTCAGGTTGGAAGAACATCTTTGCCGTGTTCCAC
CAGGCAGCCTCTGATCATGATGGGAACATTGTGGAGCTGGCCTTCCAGACCACTTGCCACATTGTCACAACTATTTTCCAGCACCATTTT
CCTGCAGCCATCGATTCCTTTCAGGATGCTGTGAAGTGCTTATCAGAGTTCGCCTGCAACGCCGCTTTCCCTGACACGAGCATGGAAGCG
ATTCGGCTCATCCGCTTCTGTGGCAAATACGTCTCTGAGAGGCCTCGGGTGCTACAAGAATACACAAGTGATGACATGAATGTAGCTCCT
GGTGACAGAGTCTGGGTCCGAGGCTGGTTCCCCATCTTATTCGAACTCTCCTGCATCATTAATAGATGCAAGTTAGATGTACGAACAAGG
GGACTCACAGTCATGTTTGAGATCATGAAGAGCTATGGCCACACCTTTGAAAAGCACTGGTGGCAGGACCTGTTCAGAATCGTGTTTCGG
ATTTTTGACAATATGAAACTCCCTGAGCAACTGTCAGAGAAATCTGAGTGGATGACAACAACCTGCAATCACGCACTTTATGCTATTTGT
GATGTTTTTACCCAGTTTTATGAAGCTTTGAATGAAGTTCTTCTTTCTGATGTATTTGCACAATTGCAGTGGTGTGTCAAACAAGATAAT
GAACAGTTGGCGCGATCAGGTACAAATTGCTTAGAAAACTTAGTAATATCCAATGGAGAGAAATTCAGTCCTGAAGTCTGGGATGAAACC
TGCAACTGTATGTTGGATATTTTCAAAACAACCATCCCACATGTTTTGCTGACATGGAGACCTGTAGGAATGGAGGAAGATTCATCAGAA
AAGCATTTGGACACAAGAAGCTCTGACGACCAGAAAGATGATATTCCCGTGGAGAACTATGTGGCTCAGCGTTACATTGAAAATCCTTAC
CTGATAGGAGGCCGCAAGTTTGACCTGCGTGTCTATGTGCTGGTGATGTCGGTGTTTGCTGAATGCCTGCTGTGGTCTGGGCACAGGAGA
CAGGATGTTCACCTCACCAACGTGGCTGTGCAAAAAACATCTCCCGACTACCACCCAAAGAAGGGCTGCAAGTGGACGCTGCAGCGCTTC
CGGCAGTACCTGGCGTCCAAACACGGGCCCGAGGCAGTGGAGACACTCTTCAGGGACATCGACAACATCTTTGTCAAAAGCCTGCAGAGT
GTGCAGAAGGTGATCATCAGTGACAAGCACTGCTTCGAGCTGTACGGCTATGACATCCTCATCGACCAGGACCTCAAGCCGTGGCTCCTG
GAGGTCAATGCGTCCCCATCACTGACAGCCAGCAGCCAGGAAGACTATGAGCTCAAGACCTGCCTCCTGGAAGACACCCTGCATGTTGTG
GACATGGAAGCGAGGCTCACGGGAAGGGAGAAGCGAGTCGGGGGCTTTGACCTCATGTGGAATGATGGCCCTGTTAGCAGAGAGGAGGGG
GCTCCTGACCTGTCGGGAATGGGAAACTTTGTGACCAACACACATCTCGGCTGCGTCAACGATCGGAAGAAACAACTGAGGCAGCTCTTC
TGCTCCCTTCAAGTTCAGAAGAAAGCTTCCAGTTGATCCCCAGCTGCCAGGAGGAAATCAGCCTTAGCAGGCCTTGTGTTTGAGATTGGG
AGCTGAGCCAGAAACCGGAAAACCCTGGGCTCATGGGCAGGACAGCTTCGGGAGTTGAGTGTCAAGCCCGAAGGGAAGACTTTTGGAAGG
AAAATACTGGCAAATCCAAGAAGTGAACCAGCCGACTTTAGGAAAGCCAGAAGCCAGGCTACTCTAGACCTTCTGCCTTCAGAGCATGAG
GACTTCTCCCACTCATCCCTGTACCTGAGGCACACCAACCCAGACAGGTCCAGGCATGGACTCCAGGTTCCCTATTTCCAGAAGGAATGC
GATTAGCTTTTTTTGGCCCAGCACCCACCCTGCCAGGGAGGAAGGGGCAATTTTCCAGTGATGAAATTGTGAATCAGGCAGTCACACTGG
ACAACATCTAGCAAGGTGAATTCTGCAACTCCCTACTTTATTTACATTTTAAAATAAGCAATATATTCATACGGTTTAAAATCCAAAGTT
TACAAAAGGGTATAGGGTGACATCTCCTTCCCTCCCACCTGTGCGCCCCAACCCTGCAGGTGCTGTTCTGAGGGAATCACACTGTGCTTG
CACAAAAATTATTAGCTTATAAGACACCAGCCTTCCCCTTGCTTTCCTCACTTGATGTATCTTGGAGCTTGTTCCTTATTCTTGATTATA
GTTGTATGGTATTGCACTATCTGGAGCTAACACCTGTGACCCACACTCATGTTTTAAAAGTTTCTGCATTAGTCAAAAATATTTAAAAGG
AGATTCAACTTCACAACCCATATGTCTAGCTTCTCTTGAAAACACGTAAGAACTGGCCATGACAGCCTGTGTTTCTATGTAACTATGAGC
CAGAGCCAAGGAGCGGGGGGACCAGGAGAGGTGTGCCCCTGCCATGCTGCCATTTGTTATCACCCGCCTGTCAAATCACAGGTTTATTTC
AAGGCAAGAACCATGTTCATAGGTTGTATTCTAAATGGAGTGGCGTGCCCTTACTGAAGGACTAGATGAGGCAAATAAAGACTAGTTGCT
GCTATT

>5879_5879_5_ARFGEF2-TTLL9_ARFGEF2_chr20_47634087_ENST00000371917_TTLL9_chr20_30510766_ENST00000375938_length(amino acids)=1751AA_BP=1503
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDC
LQKLIAYGHITGNAPDSGAPGKRLIDRIVETICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQT
TAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDLTNGEHARSDSGKVSTENGDA
PRERGSSLSGTDDGAQEVVKDILEDVVTSAIKEAAEKHGLTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLSSADNLESDAQGH
QVAARFSHVLQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSVPD
VFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKI
AQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQEIGDGKGLDMARRCSVTSMESTVSSGTQTTV
QDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEK
EFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDL
PEEYLSSIYEEIEGKKIAMKETKELTIATKSTKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTP
LLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWH
EILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGST
RLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLE
KGELANFRFQKDFLRPFEHIMKKNRSPTIRDMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHF
PAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTR
GLTVMFEIMKSYGHTFEKHWWQDLFRIVFRIFDNMKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDN
EQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSEKHLDTRSSDDQKDDIPVENYVAQRYIENPY
LIGGRKFDLRVYVLVMSVFAECLLWSGHRRQDVHLTNVAVQKTSPDYHPKKGCKWTLQRFRQYLASKHGPEAVETLFRDIDNIFVKSLQS
VQKVIISDKHCFELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYELKTCLLEDTLHVVDMEARLTGREKRVGGFDLMWNDGPVSREEG
APDLSGMGNFVTNTHLGCVNDRKKQLRQLFCSLQVQKKASS

--------------------------------------------------------------
>5879_5879_6_ARFGEF2-TTLL9_ARFGEF2_chr20_47634087_ENST00000371917_TTLL9_chr20_30510766_ENST00000535842_length(transcript)=5290nt_BP=4509nt
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC
CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGATGAAATTAAAGCAGAAATAGAAAAGCAGAGGCTTGGCACTGCTGCACCACCAAAGGCA
AACTTCATTGAAGCTGACAAGTATTTTCTTCCATTCGAGCTAGCTTGCCAGTCCAAGTCCCCAAGGGTAGTCAGCACATCCCTTGACTGC
TTGCAGAAACTCATCGCATACGGGCACATCACTGGCAACGCCCCTGACAGTGGAGCCCCTGGGAAGCGGCTGATCGACAGAATTGTTGAA
ACCATTTGCAGTTGTTTTCAGGGCCCTCAGACTGATGAAGGGGTTCAGTTACAAATAATTAAGGCTCTTCTGACTGCAGTGACTTCCCCA
CACATTGAAATTCATGAGGGTACTATCCTGCAGACAGTGAGAACATGTTACAATATCTATTTGGCCAGCAAAAATCTCATCAATCAAACC
ACTGCCAAGGCTACCCTTACTCAGATGCTGAACGTCATTTTCACCCGCATGGAAAACCAAGTGTTGCAGGAGGCCAGAGAACTGGAAAAA
CCAATCCAGTCAAAACCCCAGTCCCCTGTGATCCAAGCTGCAGCAGTATCCCCAAAGTTCGTTCGTTTGAAGCACAGTCAGGCACAAAGC
AAACCAACAACTCCCGAAAAAACAGATTTAACCAACGGTGAACATGCCAGGAGTGATTCTGGAAAAGTAAGCACAGAAAATGGAGACGCA
CCCAGAGAAAGAGGCTCATCACTGTCAGGGACTGATGACGGAGCCCAGGAGGTGGTGAAGGACATCTTGGAAGATGTAGTCACATCTGCC
ATTAAAGAAGCAGCGGAAAAGCATGGTCTGACAGAACCTGAGAGAGTTCTAGGTGAACTGGAGTGCCAGGAATGTGCTATTCCCCCAGGA
GTTGATGAAAACTCACAGACCAACGGGATAGCCGATGACAGGCAGTCCTTGTCGTCAGCAGATAATCTGGAATCGGATGCACAAGGACAT
CAAGTGGCTGCCAGGTTCTCCCACGTTCTGCAGAAGGATGCCTTCCTTGTGTTCCGCTCCCTGTGCAAGCTGTCCATGAAACCCCTTGGT
GAAGGCCCTCCAGACCCAAAATCCCATGAGCTGCGTTCCAAGGTGGTTTCCCTGCAGCTGCTCCTCTCTGTGTTGCAAAATGCTGGCCCC
GTATTCAGGACTCACGAGATGTTCATCAATGCAATCAAGCAATATCTCTGTGTGGCCTTGTCCAAAAACGGCGTCTCTTCAGTGCCTGAT
GTCTTTGAGCTCTCTCTTGCCATTTTTCTTACTCTTCTTTCAAACTTTAAAATGCACTTGAAAATGCAGATAGAGGTCTTTTTCAAAGAG
ATTTTCCTGAACATTTTAGAAACATCAACAAGTTCTTTTGAGCACAGGTGGATGGTCATTCAGACTCTGACGAGGATCTGTGCAGATGCC
CAGTGTGTTGTGGATATTTATGTCAACTACGACTGTGATTTAAATGCTGCTAACATTTTTGAGCGCCTTGTAAATGATTTATCCAAAATT
GCTCAGGGAAGAAGTGGACATGAGCTGGGAATGACACCTCTGCAGGAGCTCAGCCTGAGGAAGAAAGGCCTGGAGTGCCTCGTGTCCATT
CTCAAGTGCATGGTGGAGTGGAGCAAAGACCTGTATGTGAATCCCAACCACCAGACCAGCCTCGGTCAGGAGAGGCTCACGGATCAGGAA
ATAGGGGATGGGAAAGGCCTTGACATGGCAAGACGGTGTAGTGTGACGTCCATGGAGTCCACAGTGTCCTCGGGGACCCAGACAACTGTT
CAGGATGACCCTGAGCAATTTGAGGTCATCAAGCAACAAAAAGAAATCATTGAACACGGCATCGAGCTGTTCAACAAGAAACCCAAGAGG
GGGATCCAGTTTCTCCAGGAGCAGGGCATGCTGGGAACGTCAGTTGAAGACATAGCCCAATTCCTGCACCAGGAGGAGCGCCTGGATTCC
ACCCAAGTAGGCGATTTTCTGGGAGATAGCGCAAGGTTCAACAAGGAGGTGATGTATGCCTACGTGGACCAACTTGACTTCTGTGAAAAA
GAATTTGTCTCAGCCCTGCGGACATTCCTAGAAGGTTTCCGCCTACCTGGAGAAGCCCAAAAGATTGACCGATTAATGGAGAAGTTTGCC
GCAAGATACATAGAATGCAACCAAGGGCAAACTCTGTTTGCTAGTGCTGACACTGCTTATGTCCTAGCGTATTCAATTATTATGCTGACT
ACAGACTTGCACAGTCCTCAGGTAAAAAATAAAATGACGAAAGAGCAGTATATTAAAATGAATCGGGGTATCAATGATAGTAAAGATCTG
CCAGAAGAGTATCTCTCAAGCATCTATGAAGAGATAGAAGGCAAGAAAATTGCAATGAAAGAAACAAAAGAGCTAACGATTGCAACCAAA
TCTACTAAGCAGAATGTAGCTAGTGAAAAGCAGCGGCGGCTGCTGTACAACTTAGAGATGGAGCAAATGGCTAAAACAGCCAAAGCTCTG
ATGGAGGCTGTGAGCCATGCCAAAGCCCCGTTTACCAGTGCCACTCACCTGGACCATGTCCGGCCAATGTTCAAACTGGTGTGGACGCCA
CTATTGGCAGCCTACAGCATCGGACTCCAGAACTGTGATGACACTGAAGTGGCCTCCTTGTGTTTGGAAGGCATCCGATGTGCAATCCGA
ATCGCCTGCATCTTTGGAATGCAGCTGGAACGAGATGCCTATGTTCAGGCTCTTGCTCGCTTCTCCCTACTCACAGCCAGCTCCAGCATC
ACAGAAATGAAGCAGAAAAACATCGACACCATTAAGACGCTTATCACAGTGGCTCACACCGATGGCAACTACCTTGGGAATTCCTGGCAT
GAGATCTTGAAATGCATCAGCCAGCTGGAGCTCGCTCAGCTGATAGGAACCGGTGTGAAGACGCGCTACCTGTCTGGATCTGGGCGTGAA
AGAGAAGGGAGCCTGAAGGGCCACACATTGGCAGGAGAAGAGTTCATGGGCCTTGGCCTCGGTAATTTGGTGAGTGGCGGAGTGGATAAA
AGACAGATGGCCAGCTTCCAAGAATCGGTTGGTGAGACCAGCTCGCAGAGTGTGGTTGTAGCTGTGGACAGGATTTTTACTGGGTCTACC
AGACTGGATGGAAATGCAATAGTTGACTTTGTCCGCTGGCTGTGTGCTGTGTCCATGGATGAACTGGCTTCCCCCCACCATCCTCGCATG
TTCAGCTTGCAGAAGATTGTGGAGATATCATACTACAACATGAATCGGATCCGACTACAGTGGTCTCGAATATGGCATGTGATTGGAGAT
CACTTCAATAAGGTTGGCTGCAACCCTAATGAAGATGTGGCTATCTTTGCTGTTGACTCATTAAGGCAACTCTCCATGAAGTTTCTTGAG
AAGGGTGAATTAGCCAACTTCCGTTTCCAGAAAGATTTTCTGAGGCCCTTTGAGCATATTATGAAGAAAAACAGGTCTCCCACCATCCGG
GACATGGCGATCCGCTGCATTGCCCAGATGGTGAACTCCCAGGCGGCCAACATCCGCTCAGGTTGGAAGAACATCTTTGCCGTGTTCCAC
CAGGCAGCCTCTGATCATGATGGGAACATTGTGGAGCTGGCCTTCCAGACCACTTGCCACATTGTCACAACTATTTTCCAGCACCATTTT
CCTGCAGCCATCGATTCCTTTCAGGATGCTGTGAAGTGCTTATCAGAGTTCGCCTGCAACGCCGCTTTCCCTGACACGAGCATGGAAGCG
ATTCGGCTCATCCGCTTCTGTGGCAAATACGTCTCTGAGAGGCCTCGGGTGCTACAAGAATACACAAGTGATGACATGAATGTAGCTCCT
GGTGACAGAGTCTGGGTCCGAGGCTGGTTCCCCATCTTATTCGAACTCTCCTGCATCATTAATAGATGCAAGTTAGATGTACGAACAAGG
GGACTCACAGTCATGTTTGAGATCATGAAGAGCTATGGCCACACCTTTGAAAAGCACTGGTGGCAGGACCTGTTCAGAATCGTGTTTCGG
ATTTTTGACAATATGAAACTCCCTGAGCAACTGTCAGAGAAATCTGAGTGGATGACAACAACCTGCAATCACGCACTTTATGCTATTTGT
GATGTTTTTACCCAGTTTTATGAAGCTTTGAATGAAGTTCTTCTTTCTGATGTATTTGCACAATTGCAGTGGTGTGTCAAACAAGATAAT
GAACAGTTGGCGCGATCAGGTACAAATTGCTTAGAAAACTTAGTAATATCCAATGGAGAGAAATTCAGTCCTGAAGTCTGGGATGAAACC
TGCAACTGTATGTTGGATATTTTCAAAACAACCATCCCACATGTTTTGCTGACATGGAGACCTGTAGGAATGGAGGAAGATTCATCAGAA
AAGCATTTGGACACAAGAAGCTCTGACGACCAGAAAGATGATATTCCCGTGGAGAACTATGTGGCTCAGCGTTACATTGAAAATCCTTAC
CTGATAGGAGGCCGCAAGTTTGACCTGCGTGTCTATGTGCTGGTGATGTCGGTGTTTGCTGAATGCCTGCTGTGGTCTGGGCACAGGAGA
CAGGATGTTCACCTCACCAACGTGGCTGTGCAAAAAACATCTCCCGACTACCACCCAAAGAAGGGCTGCAAGTGGACGCTGCAGCGCTTC
CGGCAGTACCTGGCGTCCAAACACGGGCCCGAGGCAGTGGAGACACTCTTCAGGGACATCGACAACATCTTTGTCAAAAGCCTGCAGAGT
GTGCAGAAGGTGATCATCAGTGACAAGCACTGCTTCGAGCTGTACGGCTATGACATCCTCATCGACCAGGACCTCAAGCCGTGGCTCCTG
GAGGTCAATGCGTCCCCATCACTGACAGCCAGCAGCCAGGAAGACTATGAGCTCAAGACCTGCCTCCTGGAAGACACCCTGCATGTTGTG
GACATGGAAGCGAGGCTCACGGGAAGGGAGAAGCGAGTCGGGGGCTTTGACCTCATGTGGAATGATGGCCCTGTTAGCAGAGAGGAGGGG
GCTCCTGACCTGTCGGGAATGGGAAACTTTGTGACCAACACACATCTCGGCTGCGTCAACGATCGGAAGAAACAACTGAGGCAGCTCTTC
TGCTCCCTTCAAGTTCAGAAGAAAGCTTCCAGTTGATCCCCAGCTGCCAGGAGGAAATCAGCCTTAGCAG

>5879_5879_6_ARFGEF2-TTLL9_ARFGEF2_chr20_47634087_ENST00000371917_TTLL9_chr20_30510766_ENST00000535842_length(amino acids)=1751AA_BP=1503
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDC
LQKLIAYGHITGNAPDSGAPGKRLIDRIVETICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQT
TAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDLTNGEHARSDSGKVSTENGDA
PRERGSSLSGTDDGAQEVVKDILEDVVTSAIKEAAEKHGLTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLSSADNLESDAQGH
QVAARFSHVLQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSVPD
VFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKI
AQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQEIGDGKGLDMARRCSVTSMESTVSSGTQTTV
QDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEK
EFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDL
PEEYLSSIYEEIEGKKIAMKETKELTIATKSTKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTP
LLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWH
EILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGST
RLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLE
KGELANFRFQKDFLRPFEHIMKKNRSPTIRDMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHF
PAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTR
GLTVMFEIMKSYGHTFEKHWWQDLFRIVFRIFDNMKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDN
EQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSEKHLDTRSSDDQKDDIPVENYVAQRYIENPY
LIGGRKFDLRVYVLVMSVFAECLLWSGHRRQDVHLTNVAVQKTSPDYHPKKGCKWTLQRFRQYLASKHGPEAVETLFRDIDNIFVKSLQS
VQKVIISDKHCFELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYELKTCLLEDTLHVVDMEARLTGREKRVGGFDLMWNDGPVSREEG
APDLSGMGNFVTNTHLGCVNDRKKQLRQLFCSLQVQKKASS

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Fusion Gene PPI Analysis for ARFGEF2-TTLL9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARFGEF2-TTLL9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARFGEF2-TTLL9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARFGEF2C1842563Heterotopia, Periventricular, Autosomal Recessive3CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneARFGEF2C1868720Periventricular Nodular Heterotopia2GENOMICS_ENGLAND;ORPHANET
TgeneC0023903Liver neoplasms1CTD_human
TgeneC0032460Polycystic Ovary Syndrome1CTD_human
TgeneC0032927Precancerous Conditions1CTD_human
TgeneC0282313Condition, Preneoplastic1CTD_human
TgeneC0345904Malignant neoplasm of liver1CTD_human
TgeneC1136382Sclerocystic Ovaries1CTD_human
TgeneC3495676Anorectal Malformations1GENOMICS_ENGLAND