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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARFGEF2-CNIH2 (FusionGDB2 ID:HG10564TG254263)

Fusion Gene Summary for ARFGEF2-CNIH2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARFGEF2-CNIH2
Fusion gene ID: hg10564tg254263
HgeneTgene
Gene symbol

ARFGEF2

CNIH2

Gene ID

10564

254263

Gene nameADP ribosylation factor guanine nucleotide exchange factor 2cornichon family AMPA receptor auxiliary protein 2
SynonymsBIG2|PVNH2|dJ1164I10.1CNIH-2|Cnil
Cytomap('ARFGEF2')('CNIH2')

20q13.13

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionbrefeldin A-inhibited guanine nucleotide-exchange protein 2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)brefeldin A-inhibited GEP 2protein cornichon homolog 2cornichon homolog 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000371917, ENST00000493140, 
Fusion gene scores* DoF score15 X 13 X 9=17552 X 3 X 2=12
# samples 153
** MAII scorelog2(15/1755*10)=-3.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARFGEF2 [Title/Abstract] AND CNIH2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARFGEF2(47558524)-CNIH2(66049730), # samples:3
Anticipated loss of major functional domain due to fusion event.ARFGEF2-CNIH2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFGEF2-CNIH2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARFGEF2

GO:0001881

receptor recycling

16477018

HgeneARFGEF2

GO:0035556

intracellular signal transduction

12571360

TgeneCNIH2

GO:2000311

regulation of AMPA receptor activity

20805473


check buttonFusion gene breakpoints across ARFGEF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CNIH2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0H6-01AARFGEF2chr20

47558524

-CNIH2chr11

66049730

+
ChimerDB4BRCATCGA-BH-A0H6-01AARFGEF2chr20

47558524

+CNIH2chr11

66049730

+
ChimerDB4BRCATCGA-BH-A0H6ARFGEF2chr20

47558524

+CNIH2chr11

66049729

+


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Fusion Gene ORF analysis for ARFGEF2-CNIH2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000371917ENST00000530519ARFGEF2chr20

47558524

+CNIH2chr11

66049730

+
5CDS-3UTRENST00000371917ENST00000530519ARFGEF2chr20

47558524

+CNIH2chr11

66049729

+
In-frameENST00000371917ENST00000311445ARFGEF2chr20

47558524

+CNIH2chr11

66049730

+
In-frameENST00000371917ENST00000311445ARFGEF2chr20

47558524

+CNIH2chr11

66049729

+
In-frameENST00000371917ENST00000528852ARFGEF2chr20

47558524

+CNIH2chr11

66049730

+
In-frameENST00000371917ENST00000528852ARFGEF2chr20

47558524

+CNIH2chr11

66049729

+
intron-3CDSENST00000493140ENST00000311445ARFGEF2chr20

47558524

+CNIH2chr11

66049730

+
intron-3CDSENST00000493140ENST00000311445ARFGEF2chr20

47558524

+CNIH2chr11

66049729

+
intron-3CDSENST00000493140ENST00000528852ARFGEF2chr20

47558524

+CNIH2chr11

66049730

+
intron-3CDSENST00000493140ENST00000528852ARFGEF2chr20

47558524

+CNIH2chr11

66049729

+
intron-3UTRENST00000493140ENST00000530519ARFGEF2chr20

47558524

+CNIH2chr11

66049730

+
intron-3UTRENST00000493140ENST00000530519ARFGEF2chr20

47558524

+CNIH2chr11

66049729

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000371917ARFGEF2chr2047558524+ENST00000528852CNIH2chr1166049730+14522760653217
ENST00000371917ARFGEF2chr2047558524+ENST00000311445CNIH2chr1166049730+12932760677225
ENST00000371917ARFGEF2chr2047558524+ENST00000528852CNIH2chr1166049729+14522760653217
ENST00000371917ARFGEF2chr2047558524+ENST00000311445CNIH2chr1166049729+12932760677225

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371917ENST00000528852ARFGEF2chr2047558524+CNIH2chr1166049730+0.0108744670.9891255
ENST00000371917ENST00000311445ARFGEF2chr2047558524+CNIH2chr1166049730+0.0104382980.98956174
ENST00000371917ENST00000528852ARFGEF2chr2047558524+CNIH2chr1166049729+0.0108744670.9891255
ENST00000371917ENST00000311445ARFGEF2chr2047558524+CNIH2chr1166049729+0.0104382980.98956174

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Fusion Genomic Features for ARFGEF2-CNIH2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARFGEF2chr2047558524+CNIH2chr1166049729+0.0001109820.999889
ARFGEF2chr2047558524+CNIH2chr1166049729+0.0001109820.999889
ARFGEF2chr2047558524+CNIH2chr1166049729+0.0001109820.999889
ARFGEF2chr2047558524+CNIH2chr1166049729+0.0001109820.999889

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARFGEF2-CNIH2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:47558524/chr11:66049730)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCNIH2chr20:47558524chr11:66049729ENST0000031144506160_16027161.0Topological domainLumenal
TgeneCNIH2chr20:47558524chr11:66049729ENST000003114450632_7227161.0Topological domainLumenal
TgeneCNIH2chr20:47558524chr11:66049729ENST000003114450694_13827161.0Topological domainCytoplasmic
TgeneCNIH2chr20:47558524chr11:66049730ENST0000031144506160_16027161.0Topological domainLumenal
TgeneCNIH2chr20:47558524chr11:66049730ENST000003114450632_7227161.0Topological domainLumenal
TgeneCNIH2chr20:47558524chr11:66049730ENST000003114450694_13827161.0Topological domainCytoplasmic
TgeneCNIH2chr20:47558524chr11:66049729ENST0000031144506139_15927161.0TransmembraneHelical
TgeneCNIH2chr20:47558524chr11:66049729ENST000003114450673_9327161.0TransmembraneHelical
TgeneCNIH2chr20:47558524chr11:66049730ENST0000031144506139_15927161.0TransmembraneHelical
TgeneCNIH2chr20:47558524chr11:66049730ENST000003114450673_9327161.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARFGEF2chr20:47558524chr11:66049729ENST00000371917+339654_785921786.0DomainSEC7
HgeneARFGEF2chr20:47558524chr11:66049730ENST00000371917+339654_785921786.0DomainSEC7
TgeneCNIH2chr20:47558524chr11:66049729ENST00000311445061_1027161.0Topological domainCytoplasmic
TgeneCNIH2chr20:47558524chr11:66049730ENST00000311445061_1027161.0Topological domainCytoplasmic
TgeneCNIH2chr20:47558524chr11:66049729ENST000003114450611_3127161.0TransmembraneHelical
TgeneCNIH2chr20:47558524chr11:66049730ENST000003114450611_3127161.0TransmembraneHelical


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Fusion Gene Sequence for ARFGEF2-CNIH2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5867_5867_1_ARFGEF2-CNIH2_ARFGEF2_chr20_47558524_ENST00000371917_CNIH2_chr11_66049729_ENST00000311445_length(transcript)=1293nt_BP=276nt
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC
CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGATGAAATTAAAGCAGAAATAGAAAAGCAGAGGCTTGGCACTGCTGCACCACCAAAGGCA
AACTTCATTGAAGCTGACAAGTATTTTCTTCCATTCGAGCTAGCTTGCCAGTCCAAGTCCCCAAGGGTAGTCAGCACATCCCTTGACTGC
TTGCAGATCATAGCCTTTGATGAGCTGCGGACCGACTTCAAGAACCCCATCGACCAGGGGAACCCTGCGCGGGCACGCGAGCGTTTAAAA
AACATCGAACGCATCTGCTGCCTCCTGAGGAAGCTGGTGGTCCCAGAATACTCCATCCACGGCCTCTTCTGTCTGATGTTTCTGTGTGCA
GCAGAGTGGGTGACCCTGGGCCTCAACATCCCCCTCCTCTTCTACCACCTCTGGAGGTACTTCCACCGTCCTGCAGATGGCTCTGAGGTC
ATGTATGATGCGGTCTCCATCATGAATGCTGACATTCTCAACTACTGCCAGAAGGAGTCCTGGTGCAAACTTGCCTTCTACCTGCTCTCC
TTCTTCTATTACCTGTACAGTATGGTTTATACGTTGGTGAGTTTCTAAGGGGGAAGCCGGCCAGGGAGCGAGCCCAGAACGGACCGGACG
CCTGTGCACCCCCAGCCCTGCCCCTTGGCCGCAGAGGCCTCAGCCCTGGGGAGGGAGGGGGCACTGGTGCCCCCAGCCTCTCCAACCCCC
AAACTGCTGCTGCGGGGAACCCCCCCCACCCCGCCTTCAGAGCCCTCCCCCTTGGACTAGAGCGGCTGGGCAGAGCTCTAAACAGGGGCA
GGGGCTCCTCTGCCAGCCTGTGGGCATGGCAGTCATTCCTGGAAGGGGCAGGACCTCCGGCCTTGTCCATTTCGGGGGAAACTTGGGCCC
TGCCAAGGGGCAGAGCTTGACCCTGGAAATTCTGGGCCATCCCCCTCCACCCCCACCCTGAGGCTCCCCCTGCAGGTGGGGGGGTACCCG
CACCGGGAATGAGCAGGCTCAGCAGGGGGGCAGCCCCACCCCTAGTCTGCCCTCCCCTCTCCCCCAGGCTCTTTCTCCAGCCCTGTCTCC
ATCTGCCCCAACCTCAGCCCACCTTGTCTCTTGGACCTATTTTCTATGTCGCCTGGAGGAGTCCGGCACCCCCTCCCCGGCCATTTGTGA

>5867_5867_1_ARFGEF2-CNIH2_ARFGEF2_chr20_47558524_ENST00000371917_CNIH2_chr11_66049729_ENST00000311445_length(amino acids)=225AA_BP=91
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDC
LQIIAFDELRTDFKNPIDQGNPARARERLKNIERICCLLRKLVVPEYSIHGLFCLMFLCAAEWVTLGLNIPLLFYHLWRYFHRPADGSEV

--------------------------------------------------------------
>5867_5867_2_ARFGEF2-CNIH2_ARFGEF2_chr20_47558524_ENST00000371917_CNIH2_chr11_66049729_ENST00000528852_length(transcript)=1452nt_BP=276nt
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC
CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGATGAAATTAAAGCAGAAATAGAAAAGCAGAGGCTTGGCACTGCTGCACCACCAAAGGCA
AACTTCATTGAAGCTGACAAGTATTTTCTTCCATTCGAGCTAGCTTGCCAGTCCAAGTCCCCAAGGGTAGTCAGCACATCCCTTGACTGC
TTGCAGATCATAGCCTTTGATGAGCTGCGGACCGACTTCAAGAACCCCATCGACCAGGGGAACCCTGCGCGGGCACGCGAGCGTTTAAAA
AACATCGAACGCATCTGCTGCCTCCTGAGGAAGCTGGTGGTCCCAGAATACTCCATCCACGGCCTCTTCTGTCTGATGTTTCTGTGTGCA
GCAGAGTGGGTGACCCTGGGCCTCAACATCCCCCTCCTCTTCTACCACCTCTGGAGGTACTTCCACCGTCCTGCAGATGGCTCTGAGGTC
ATGTATGATGCGGTCTCCATCATGAATGCTGACATTCTCAACTACTGCCAGAAGGAGTCCTGGTGCAAACTTGCCTTCTACCTGCTCTCC
TTCTTCTATTACCTGTACAGGTGAGGCCTTGCCCACAGCAGTCAGAACTCAGGGAAGGGATGTCCCAGCATCACGCTTCCAATCCCAAGT
TCCTGCCTTTTGCCCCTGAGGACTGAGGGCAGCCCAGGGTGTGACCAGGTGGGCATCTGGGTGGCTGTGTGTGTGCAGGGCTAGGCTCAC
TGGCTCATCTTCCTACAGTATGGTTTATACGTTGGTGAGTTTCTAAGGGGGAAGCCGGCCAGGGAGCGAGCCCAGAACGGACCGGACGCC
TGTGCACCCCCAGCCCTGCCCCTTGGCCGCAGAGGCCTCAGCCCTGGGGAGGGAGGGGGCACTGGTGCCCCCAGCCTCTCCAACCCCCAA
ACTGCTGCTGCGGGGAACCCCCCCCACCCCGCCTTCAGAGCCCTCCCCCTTGGACTAGAGCGGCTGGGCAGAGCTCTAAACAGGGGCAGG
GGCTCCTCTGCCAGCCTGTGGGCATGGCAGTCATTCCTGGAAGGGGCAGGACCTCCGGCCTTGTCCATTTCGGGGGAAACTTGGGCCCTG
CCAAGGGGCAGAGCTTGACCCTGGAAATTCTGGGCCATCCCCCTCCACCCCCACCCTGAGGCTCCCCCTGCAGGTGGGGGGGTACCCGCA
CCGGGAATGAGCAGGCTCAGCAGGGGGGCAGCCCCACCCCTAGTCTGCCCTCCCCTCTCCCCCAGGCTCTTTCTCCAGCCCTGTCTCCAT
CTGCCCCAACCTCAGCCCACCTTGTCTCTTGGACCTATTTTCTATGTCGCCTGGAGGAGTCCGGCACCCCCTCCCCGGCCATTTGTGACA

>5867_5867_2_ARFGEF2-CNIH2_ARFGEF2_chr20_47558524_ENST00000371917_CNIH2_chr11_66049729_ENST00000528852_length(amino acids)=217AA_BP=91
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDC
LQIIAFDELRTDFKNPIDQGNPARARERLKNIERICCLLRKLVVPEYSIHGLFCLMFLCAAEWVTLGLNIPLLFYHLWRYFHRPADGSEV

--------------------------------------------------------------
>5867_5867_3_ARFGEF2-CNIH2_ARFGEF2_chr20_47558524_ENST00000371917_CNIH2_chr11_66049730_ENST00000311445_length(transcript)=1293nt_BP=276nt
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC
CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGATGAAATTAAAGCAGAAATAGAAAAGCAGAGGCTTGGCACTGCTGCACCACCAAAGGCA
AACTTCATTGAAGCTGACAAGTATTTTCTTCCATTCGAGCTAGCTTGCCAGTCCAAGTCCCCAAGGGTAGTCAGCACATCCCTTGACTGC
TTGCAGATCATAGCCTTTGATGAGCTGCGGACCGACTTCAAGAACCCCATCGACCAGGGGAACCCTGCGCGGGCACGCGAGCGTTTAAAA
AACATCGAACGCATCTGCTGCCTCCTGAGGAAGCTGGTGGTCCCAGAATACTCCATCCACGGCCTCTTCTGTCTGATGTTTCTGTGTGCA
GCAGAGTGGGTGACCCTGGGCCTCAACATCCCCCTCCTCTTCTACCACCTCTGGAGGTACTTCCACCGTCCTGCAGATGGCTCTGAGGTC
ATGTATGATGCGGTCTCCATCATGAATGCTGACATTCTCAACTACTGCCAGAAGGAGTCCTGGTGCAAACTTGCCTTCTACCTGCTCTCC
TTCTTCTATTACCTGTACAGTATGGTTTATACGTTGGTGAGTTTCTAAGGGGGAAGCCGGCCAGGGAGCGAGCCCAGAACGGACCGGACG
CCTGTGCACCCCCAGCCCTGCCCCTTGGCCGCAGAGGCCTCAGCCCTGGGGAGGGAGGGGGCACTGGTGCCCCCAGCCTCTCCAACCCCC
AAACTGCTGCTGCGGGGAACCCCCCCCACCCCGCCTTCAGAGCCCTCCCCCTTGGACTAGAGCGGCTGGGCAGAGCTCTAAACAGGGGCA
GGGGCTCCTCTGCCAGCCTGTGGGCATGGCAGTCATTCCTGGAAGGGGCAGGACCTCCGGCCTTGTCCATTTCGGGGGAAACTTGGGCCC
TGCCAAGGGGCAGAGCTTGACCCTGGAAATTCTGGGCCATCCCCCTCCACCCCCACCCTGAGGCTCCCCCTGCAGGTGGGGGGGTACCCG
CACCGGGAATGAGCAGGCTCAGCAGGGGGGCAGCCCCACCCCTAGTCTGCCCTCCCCTCTCCCCCAGGCTCTTTCTCCAGCCCTGTCTCC
ATCTGCCCCAACCTCAGCCCACCTTGTCTCTTGGACCTATTTTCTATGTCGCCTGGAGGAGTCCGGCACCCCCTCCCCGGCCATTTGTGA

>5867_5867_3_ARFGEF2-CNIH2_ARFGEF2_chr20_47558524_ENST00000371917_CNIH2_chr11_66049730_ENST00000311445_length(amino acids)=225AA_BP=91
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDC
LQIIAFDELRTDFKNPIDQGNPARARERLKNIERICCLLRKLVVPEYSIHGLFCLMFLCAAEWVTLGLNIPLLFYHLWRYFHRPADGSEV

--------------------------------------------------------------
>5867_5867_4_ARFGEF2-CNIH2_ARFGEF2_chr20_47558524_ENST00000371917_CNIH2_chr11_66049730_ENST00000528852_length(transcript)=1452nt_BP=276nt
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC
CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGATGAAATTAAAGCAGAAATAGAAAAGCAGAGGCTTGGCACTGCTGCACCACCAAAGGCA
AACTTCATTGAAGCTGACAAGTATTTTCTTCCATTCGAGCTAGCTTGCCAGTCCAAGTCCCCAAGGGTAGTCAGCACATCCCTTGACTGC
TTGCAGATCATAGCCTTTGATGAGCTGCGGACCGACTTCAAGAACCCCATCGACCAGGGGAACCCTGCGCGGGCACGCGAGCGTTTAAAA
AACATCGAACGCATCTGCTGCCTCCTGAGGAAGCTGGTGGTCCCAGAATACTCCATCCACGGCCTCTTCTGTCTGATGTTTCTGTGTGCA
GCAGAGTGGGTGACCCTGGGCCTCAACATCCCCCTCCTCTTCTACCACCTCTGGAGGTACTTCCACCGTCCTGCAGATGGCTCTGAGGTC
ATGTATGATGCGGTCTCCATCATGAATGCTGACATTCTCAACTACTGCCAGAAGGAGTCCTGGTGCAAACTTGCCTTCTACCTGCTCTCC
TTCTTCTATTACCTGTACAGGTGAGGCCTTGCCCACAGCAGTCAGAACTCAGGGAAGGGATGTCCCAGCATCACGCTTCCAATCCCAAGT
TCCTGCCTTTTGCCCCTGAGGACTGAGGGCAGCCCAGGGTGTGACCAGGTGGGCATCTGGGTGGCTGTGTGTGTGCAGGGCTAGGCTCAC
TGGCTCATCTTCCTACAGTATGGTTTATACGTTGGTGAGTTTCTAAGGGGGAAGCCGGCCAGGGAGCGAGCCCAGAACGGACCGGACGCC
TGTGCACCCCCAGCCCTGCCCCTTGGCCGCAGAGGCCTCAGCCCTGGGGAGGGAGGGGGCACTGGTGCCCCCAGCCTCTCCAACCCCCAA
ACTGCTGCTGCGGGGAACCCCCCCCACCCCGCCTTCAGAGCCCTCCCCCTTGGACTAGAGCGGCTGGGCAGAGCTCTAAACAGGGGCAGG
GGCTCCTCTGCCAGCCTGTGGGCATGGCAGTCATTCCTGGAAGGGGCAGGACCTCCGGCCTTGTCCATTTCGGGGGAAACTTGGGCCCTG
CCAAGGGGCAGAGCTTGACCCTGGAAATTCTGGGCCATCCCCCTCCACCCCCACCCTGAGGCTCCCCCTGCAGGTGGGGGGGTACCCGCA
CCGGGAATGAGCAGGCTCAGCAGGGGGGCAGCCCCACCCCTAGTCTGCCCTCCCCTCTCCCCCAGGCTCTTTCTCCAGCCCTGTCTCCAT
CTGCCCCAACCTCAGCCCACCTTGTCTCTTGGACCTATTTTCTATGTCGCCTGGAGGAGTCCGGCACCCCCTCCCCGGCCATTTGTGACA

>5867_5867_4_ARFGEF2-CNIH2_ARFGEF2_chr20_47558524_ENST00000371917_CNIH2_chr11_66049730_ENST00000528852_length(amino acids)=217AA_BP=91
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDC
LQIIAFDELRTDFKNPIDQGNPARARERLKNIERICCLLRKLVVPEYSIHGLFCLMFLCAAEWVTLGLNIPLLFYHLWRYFHRPADGSEV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARFGEF2-CNIH2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARFGEF2-CNIH2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARFGEF2-CNIH2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARFGEF2C1842563Heterotopia, Periventricular, Autosomal Recessive3CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneARFGEF2C1868720Periventricular Nodular Heterotopia2GENOMICS_ENGLAND;ORPHANET