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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARFGEF1-PPP1R42 (FusionGDB2 ID:HG10565TG286187)

Fusion Gene Summary for ARFGEF1-PPP1R42

check button Fusion gene summary
Fusion gene informationFusion gene name: ARFGEF1-PPP1R42
Fusion gene ID: hg10565tg286187
HgeneTgene
Gene symbol

ARFGEF1

PPP1R42

Gene ID

10565

286187

Gene nameADP ribosylation factor guanine nucleotide exchange factor 1protein phosphatase 1 regulatory subunit 42
SynonymsARFGEP1|BIG1|P200LRRC67|TLLR|TLRR|dtr
Cytomap('ARFGEF1')('PPP1R42')

8q13.2

8q13.1

Type of geneprotein-codingprotein-coding
Descriptionbrefeldin A-inhibited guanine nucleotide-exchange protein 1ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)p200 ARF guanine nucleotide exchange factorprotein phosphatase 1 regulatory subunit 42leucine rich repeat containing 67leucine-rich repeat-containing protein 67testis leucine-rich repeat
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262215, ENST00000520381, 
ENST00000517955, ENST00000518230, 
Fusion gene scores* DoF score14 X 14 X 6=11764 X 4 X 4=64
# samples 175
** MAII scorelog2(17/1176*10)=-2.79028140869866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARFGEF1 [Title/Abstract] AND PPP1R42 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARFGEF1(68163534)-PPP1R42(67926827), # samples:1
Anticipated loss of major functional domain due to fusion event.ARFGEF1-PPP1R42 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFGEF1-PPP1R42 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARFGEF1

GO:0034260

negative regulation of GTPase activity

15644318


check buttonFusion gene breakpoints across ARFGEF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PPP1R42 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N8-A4PI-01AARFGEF1chr8

68163534

-PPP1R42chr8

67926827

-


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Fusion Gene ORF analysis for ARFGEF1-PPP1R42

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262215ENST00000517834ARFGEF1chr8

68163534

-PPP1R42chr8

67926827

-
5CDS-intronENST00000520381ENST00000517834ARFGEF1chr8

68163534

-PPP1R42chr8

67926827

-
In-frameENST00000262215ENST00000324682ARFGEF1chr8

68163534

-PPP1R42chr8

67926827

-
In-frameENST00000262215ENST00000522909ARFGEF1chr8

68163534

-PPP1R42chr8

67926827

-
In-frameENST00000520381ENST00000324682ARFGEF1chr8

68163534

-PPP1R42chr8

67926827

-
In-frameENST00000520381ENST00000522909ARFGEF1chr8

68163534

-PPP1R42chr8

67926827

-
intron-3CDSENST00000517955ENST00000324682ARFGEF1chr8

68163534

-PPP1R42chr8

67926827

-
intron-3CDSENST00000517955ENST00000522909ARFGEF1chr8

68163534

-PPP1R42chr8

67926827

-
intron-3CDSENST00000518230ENST00000324682ARFGEF1chr8

68163534

-PPP1R42chr8

67926827

-
intron-3CDSENST00000518230ENST00000522909ARFGEF1chr8

68163534

-PPP1R42chr8

67926827

-
intron-intronENST00000517955ENST00000517834ARFGEF1chr8

68163534

-PPP1R42chr8

67926827

-
intron-intronENST00000518230ENST00000517834ARFGEF1chr8

68163534

-PPP1R42chr8

67926827

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000520381ARFGEF1chr868163534-ENST00000522909PPP1R42chr867926827-22481280322080682
ENST00000520381ARFGEF1chr868163534-ENST00000324682PPP1R42chr867926827-20901280321837601
ENST00000262215ARFGEF1chr868163534-ENST00000522909PPP1R42chr867926827-4208324039040401216
ENST00000262215ARFGEF1chr868163534-ENST00000324682PPP1R42chr867926827-4050324039037971135

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000520381ENST00000522909ARFGEF1chr868163534-PPP1R42chr867926827-0.0012287920.99877113
ENST00000520381ENST00000324682ARFGEF1chr868163534-PPP1R42chr867926827-0.000604580.9993954
ENST00000262215ENST00000522909ARFGEF1chr868163534-PPP1R42chr867926827-0.000551360.9994486
ENST00000262215ENST00000324682ARFGEF1chr868163534-PPP1R42chr867926827-0.0003122070.9996878

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Fusion Genomic Features for ARFGEF1-PPP1R42


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ARFGEF1-PPP1R42


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:68163534/chr8:67926827)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARFGEF1chr8:68163534chr8:67926827ENST00000262215-1939709_8409501850.0DomainSEC7
HgeneARFGEF1chr8:68163534chr8:67926827ENST00000262215-1939711_7159501850.0MotifNote=Nuclear localization signal (NLS)
TgenePPP1R42chr8:68163534chr8:67926827ENST0000032468216204_24243229.0DomainNote=LRRCT
TgenePPP1R42chr8:68163534chr8:67926827ENST0000032468216117_13843229.0RepeatNote=LRR 5
TgenePPP1R42chr8:68163534chr8:67926827ENST0000032468216147_16843229.0RepeatNote=LRR 6
TgenePPP1R42chr8:68163534chr8:67926827ENST0000032468216169_19043229.0RepeatNote=LRR 7
TgenePPP1R42chr8:68163534chr8:67926827ENST000003246821651_7243229.0RepeatNote=LRR 2
TgenePPP1R42chr8:68163534chr8:67926827ENST000003246821673_9443229.0RepeatNote=LRR 3
TgenePPP1R42chr8:68163534chr8:67926827ENST000003246821695_11643229.0RepeatNote=LRR 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePPP1R42chr8:68163534chr8:67926827ENST000003246821629_5043229.0RepeatNote=LRR 1


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Fusion Gene Sequence for ARFGEF1-PPP1R42


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5859_5859_1_ARFGEF1-PPP1R42_ARFGEF1_chr8_68163534_ENST00000262215_PPP1R42_chr8_67926827_ENST00000324682_length(transcript)=4050nt_BP=3240nt
GCGGTGCCTCTGAGAGCCGCCGCCACCTCGTCCCTCAGTTCCCGGCAGACAGCCGCCCGGGCCGGGCTCCCTCACCGCCACCAGGGCCGG
AGGGACGAGTGAGAGGGGCGGCCGGGACGCGACCCCCGGGCCGGGAGAAGCGGAGGCCCGACGGGCGCGGCCCTCGAGGTACGGCTTCTT
GGGGGCGGCGAGGACCTCGACGCCCTTCGCCGACACCGCGGCTGGTCCCGCTCGCCCGCCCCTTCCTGATCCTGCCGCTGCCCTCCACGC
CTCCAATCCCCCACCTCCACCCCCTCTCCTTTCTCTCTTCTCTTCCTTCCTCTCCTCCTCCTCCCCTCCAGCCGCTGGGAGCCGCGGGTC
GGACGAGCCGCCGCCTCCTTCTCTGCGTCCATGTATGAGGGGAAGAAGACGAAGAACATGTTCCTGACCCGGGCTCTGGAGAAGATATTG
GCCGACAAGGAAGTGAAGAAGGCGCATCACTCCCAGCTGCGCAAAGCTTGCGAGGTGGCGTTAGAGGAAATAAAAGCGGAAACTGAAAAA
CAGAGTCCTCCTCATGGAGAAGCAAAAGCTGGATCAAGCACCCTTCCACCAGTGAAATCAAAGACAAATTTTATTGAAGCAGACAAGTAC
TTCTTGCCTTTTGAGTTGGCATGCCAGTCCAAATGTCCTCGCATAGTTAGTACATCTCTAGATTGCTTACAGAAACTTATTGCTTATGGG
CACTTGACTGGCAATGCTCCAGATAGTACAACACCAGGCAAAAAATTAATTGATAGAATTATTGAAACAATATGTGGCTGCTTTCAGGGC
CCTCAGACAGATGAAGGAGTTCAGCTGCAGATAATAAAGGCTTTACTTACTGCAGTAACATCACAACACATAGAAATTCATGAAGGGACT
GTACTGCAAGCTGTGAGAACATGTTACAATATCTACTTAGCAAGCAAAAATCTCATCAATCAGACAACAGCCAAAGCTACTCTCACTCAG
ATGCTAAATGTTATCTTTGCACGCATGGAAAACCAAGCATTACAGGAAGCAAAACAAATGGAAAAAGAAAGGCATCGGCAGCATCATCAT
CTGTTACAGTCTCCAGTAAGCCATCACGAGCCTGAATCACCTCAACTTAGATATTTGCCACCTCAGACTGTTGATCATATATCCCAAGAA
CACGAAGGGGACCTTGACCTCCATACAAATGATGTAGATAAAAGTCTTCAGGATGACACAGAGCCTGAAAATGGATCTGATATTTCCAGT
GCAGAAAATGAACAGACTGAAGCTGATCAGGCAACTGCAGCTGAAACATTATCTAAAAATGAAGTGTTATATGACGGAGAAAACCATGAT
TGTGAGGAAAAGCCACAAGACATTGTACAGAACATTGTAGAAGAAATGGTGAACATTGTTGTTGGAGATATGGGAGAAGGGACTACTATA
AATGCAAGTGCAGATGGCAACATTGGAACTATAGAGGATGGTAGTGACAGTGAAAATATTCAAGCAAATGGAATTCCAGGAACACCAATT
TCTGTTGCATATACACCATCCTTACCTGATGATAGATTGTCAGTCTCTTCCAATGATACTCAGGAATCTGGAAATTCTTCAGGACCTTCA
CCTGGTGCTAAGTTTTCCCACATTTTACAAAAGGATGCCTTTCTAGTATTCAGGTCATTGTGTAAACTGTCAATGAAACCACTGTCAGAT
GGACCACCAGATCCAAAGTCTCATGAACTACGATCCAAGATTCTTTCATTGCAGTTACTTCTATCCATTCTGCAGAATGCAGGACCTATT
TTCAGGACAAATGAGATGTTTATTAATGCTATTAAGCAGTATCTTTGTGTTGCACTCTCAAAAAATGGAGTCTCATCTGTTCCAGAGGTT
TTTGAGCTTTCTCTTTCTATATTTCTTACTTTGTTGTCAAATTTCAAGACACATCTGAAGATGCAAATTGAGGTGTTCTTTAAAGAAATT
TTCTTATACATTTTGGAAACTTCTACCAGCTCATTTGATCACAAATGGATGGTTATTCAGACACTGACGAGGATTTGTGCAGATGCTCAG
AGTGTAGTGGATATTTATGTAAACTATGACTGTGACTTAAATGCAGCCAATATATTTGAAAGACTAGTAAATGATCTATCAAAAATTGCT
CAAGGAAGGGGCAGTCAAGAACTTGGTATGAGTAATGTTCAGGAATTGAGCCTGAGGAAAAAAGGTTTAGAATGCTTAGTGTCGATTTTG
AAGTGTATGGTTGAATGGAGTAAGGATCAGTATGTGAATCCCAACTCCCAGACAACTCTTGGTCAGGAAAAACCCTCAGAGCAAGAGATG
AGTGAAATCAAACACCCTGAGACAATAAACAGATACGGAAGTTTAAATTCCCTGGAGTCAACATCATCATCAGGAATAGGCAGCTACAGT
ACACAGATGTCTGGCACTGATAATCCAGAACAATTTGAGGTCCTAAAGCAACAAAAAGAAATAATAGAACAAGGGATAGATTTATTTAAT
AAGAAACCAAAGAGAGGAATACAGTACCTCCAAGAACAAGGGATGCTTGGCACCACACCTGAAGATATTGCCCAATTCTTACATCAAGAG
GAAAGATTAGACTCTACTCAAGTGGGTGAGTTCCTGGGAGATAATGATAAATTTAACAAAGAAGTCATGTATGCATATGTGGACCAACAT
GACTTTTCAGGAAAAGACTTCGTTTCAGCCCTTCGTATGTTTCTAGAAGGATTTCGTCTTCCAGGGGAAGCTCAGAAAATCGATCGATTA
ATGGAAAAATTTGCTGCAAGATACCTAGAATGCAACCAAGGACAAACTCTCTTTGCTAGTGCGGATACAGCTTATGTTTTGGCTTATTCA
ATTATCATGTTGACCACAGACCTTCACAGTCCACAGGTGAAAAATAAAATGACAAAGGAACAATACATTAAGATGAATAGAGGTATCAAT
GACAGTAAAGACCTTCCTGAAGAGTATCTATCAGCCATCTATAATGAAATAGCTGGGAAAAAGATATCAATGAAAGAAACAAAAGAACTA
ACAATCCCTACAAAATCAAGTAAACAGAATGTAGCCAGTGAAAAACAAAGAAGACTTCTGTATAACTTAGAAATGGAGCAGATGGCCAAG
ACAGCTAAAGCACTCATGGAGGCCGTGAGCCATGTTCAGGCACCCTTTACAAGTGCAACACATTTGGAGCATGTGAGGCCCATGTTTAAG
GAAGACCTCTCTCTTTGCAAAAATCTTAGTGTTTTATATTTATATGATAATTGTATTAGTCAAATCACTAACCTGAATTATGCCACAAAT
CTGACCCACTTGTACCTACAAAACAATTGTATTTCATGTATAGAGAACCTCAGGTCATTAAAGAAACTGGAAAAACTGTATCTGGGAGGC
AATTACATTGCTGTCATAGAAGGTTTAGAAGGATTAGGAGAACTAAGAGAGCTTCATGTTGAGAATCAGAGGCTTCCCCTTGGGGAAAAG
CTTCTGTTTGATCCAAGAACTCTTCATTCTCTGGCAAAATCCCTCTGTATATTGAATATCAGCAATAATAATATTGATGACATTACAGAC
TTAGAACTACTAGAGAATCTTAATCAGCTCATAGCCGTTGACAACCAACTTCTGCATGTGAAGGATTTGGAGTTTTTACTGAACAAGTTG
ATGAAGCTGTGGAAAATTGATCTAAATGGAAATCCTGTTTGTCTCAAACCAAAATACAGGGACAGACTGATATTGGTGTCCAAATCACTG
GGTACATATTTATATTAATATAATTTTTAAGAGAATGACACCTAGTTAACTTTTTGGTTATTTTACCAGCAAGCTTTCAGAAATATAAAT
CTGACATCTGGATCTGTGAAAATTGTCAACTTTAAATTCAATATTTTGAATAAGAGCAAAAGTTAAAATTGACAAATAAAGCATGAAAAA
CATCTGCTGTTCAGAAGTAATTAAAGCACCTGATACTTATTCCTTAAGGAGGATATTTTGCTATTACCAATAAAAATGGTTAGTCATAAA

>5859_5859_1_ARFGEF1-PPP1R42_ARFGEF1_chr8_68163534_ENST00000262215_PPP1R42_chr8_67926827_ENST00000324682_length(amino acids)=1135AA_BP=0
MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKAGSSTLPPVKSKTNFIEADKYFLPFELACQS
KCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYN
IYLASKNLINQTTAKATLTQMLNVIFARMENQALQEAKQMEKERHRQHHHLLQSPVSHHEPESPQLRYLPPQTVDHISQEHEGDLDLHTN
DVDKSLQDDTEPENGSDISSAENEQTEADQATAAETLSKNEVLYDGENHDCEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGT
IEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQKDAFLVFRSLCKLSMKPLSDGPPDPKSHEL
RSKILSLQLLLSILQNAGPIFRTNEMFINAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTS
SFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQ
YVNPNSQTTLGQEKPSEQEMSEIKHPETINRYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYL
QEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLE
CNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQN
VASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNC
ISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELLENLNQL

--------------------------------------------------------------
>5859_5859_2_ARFGEF1-PPP1R42_ARFGEF1_chr8_68163534_ENST00000262215_PPP1R42_chr8_67926827_ENST00000522909_length(transcript)=4208nt_BP=3240nt
GCGGTGCCTCTGAGAGCCGCCGCCACCTCGTCCCTCAGTTCCCGGCAGACAGCCGCCCGGGCCGGGCTCCCTCACCGCCACCAGGGCCGG
AGGGACGAGTGAGAGGGGCGGCCGGGACGCGACCCCCGGGCCGGGAGAAGCGGAGGCCCGACGGGCGCGGCCCTCGAGGTACGGCTTCTT
GGGGGCGGCGAGGACCTCGACGCCCTTCGCCGACACCGCGGCTGGTCCCGCTCGCCCGCCCCTTCCTGATCCTGCCGCTGCCCTCCACGC
CTCCAATCCCCCACCTCCACCCCCTCTCCTTTCTCTCTTCTCTTCCTTCCTCTCCTCCTCCTCCCCTCCAGCCGCTGGGAGCCGCGGGTC
GGACGAGCCGCCGCCTCCTTCTCTGCGTCCATGTATGAGGGGAAGAAGACGAAGAACATGTTCCTGACCCGGGCTCTGGAGAAGATATTG
GCCGACAAGGAAGTGAAGAAGGCGCATCACTCCCAGCTGCGCAAAGCTTGCGAGGTGGCGTTAGAGGAAATAAAAGCGGAAACTGAAAAA
CAGAGTCCTCCTCATGGAGAAGCAAAAGCTGGATCAAGCACCCTTCCACCAGTGAAATCAAAGACAAATTTTATTGAAGCAGACAAGTAC
TTCTTGCCTTTTGAGTTGGCATGCCAGTCCAAATGTCCTCGCATAGTTAGTACATCTCTAGATTGCTTACAGAAACTTATTGCTTATGGG
CACTTGACTGGCAATGCTCCAGATAGTACAACACCAGGCAAAAAATTAATTGATAGAATTATTGAAACAATATGTGGCTGCTTTCAGGGC
CCTCAGACAGATGAAGGAGTTCAGCTGCAGATAATAAAGGCTTTACTTACTGCAGTAACATCACAACACATAGAAATTCATGAAGGGACT
GTACTGCAAGCTGTGAGAACATGTTACAATATCTACTTAGCAAGCAAAAATCTCATCAATCAGACAACAGCCAAAGCTACTCTCACTCAG
ATGCTAAATGTTATCTTTGCACGCATGGAAAACCAAGCATTACAGGAAGCAAAACAAATGGAAAAAGAAAGGCATCGGCAGCATCATCAT
CTGTTACAGTCTCCAGTAAGCCATCACGAGCCTGAATCACCTCAACTTAGATATTTGCCACCTCAGACTGTTGATCATATATCCCAAGAA
CACGAAGGGGACCTTGACCTCCATACAAATGATGTAGATAAAAGTCTTCAGGATGACACAGAGCCTGAAAATGGATCTGATATTTCCAGT
GCAGAAAATGAACAGACTGAAGCTGATCAGGCAACTGCAGCTGAAACATTATCTAAAAATGAAGTGTTATATGACGGAGAAAACCATGAT
TGTGAGGAAAAGCCACAAGACATTGTACAGAACATTGTAGAAGAAATGGTGAACATTGTTGTTGGAGATATGGGAGAAGGGACTACTATA
AATGCAAGTGCAGATGGCAACATTGGAACTATAGAGGATGGTAGTGACAGTGAAAATATTCAAGCAAATGGAATTCCAGGAACACCAATT
TCTGTTGCATATACACCATCCTTACCTGATGATAGATTGTCAGTCTCTTCCAATGATACTCAGGAATCTGGAAATTCTTCAGGACCTTCA
CCTGGTGCTAAGTTTTCCCACATTTTACAAAAGGATGCCTTTCTAGTATTCAGGTCATTGTGTAAACTGTCAATGAAACCACTGTCAGAT
GGACCACCAGATCCAAAGTCTCATGAACTACGATCCAAGATTCTTTCATTGCAGTTACTTCTATCCATTCTGCAGAATGCAGGACCTATT
TTCAGGACAAATGAGATGTTTATTAATGCTATTAAGCAGTATCTTTGTGTTGCACTCTCAAAAAATGGAGTCTCATCTGTTCCAGAGGTT
TTTGAGCTTTCTCTTTCTATATTTCTTACTTTGTTGTCAAATTTCAAGACACATCTGAAGATGCAAATTGAGGTGTTCTTTAAAGAAATT
TTCTTATACATTTTGGAAACTTCTACCAGCTCATTTGATCACAAATGGATGGTTATTCAGACACTGACGAGGATTTGTGCAGATGCTCAG
AGTGTAGTGGATATTTATGTAAACTATGACTGTGACTTAAATGCAGCCAATATATTTGAAAGACTAGTAAATGATCTATCAAAAATTGCT
CAAGGAAGGGGCAGTCAAGAACTTGGTATGAGTAATGTTCAGGAATTGAGCCTGAGGAAAAAAGGTTTAGAATGCTTAGTGTCGATTTTG
AAGTGTATGGTTGAATGGAGTAAGGATCAGTATGTGAATCCCAACTCCCAGACAACTCTTGGTCAGGAAAAACCCTCAGAGCAAGAGATG
AGTGAAATCAAACACCCTGAGACAATAAACAGATACGGAAGTTTAAATTCCCTGGAGTCAACATCATCATCAGGAATAGGCAGCTACAGT
ACACAGATGTCTGGCACTGATAATCCAGAACAATTTGAGGTCCTAAAGCAACAAAAAGAAATAATAGAACAAGGGATAGATTTATTTAAT
AAGAAACCAAAGAGAGGAATACAGTACCTCCAAGAACAAGGGATGCTTGGCACCACACCTGAAGATATTGCCCAATTCTTACATCAAGAG
GAAAGATTAGACTCTACTCAAGTGGGTGAGTTCCTGGGAGATAATGATAAATTTAACAAAGAAGTCATGTATGCATATGTGGACCAACAT
GACTTTTCAGGAAAAGACTTCGTTTCAGCCCTTCGTATGTTTCTAGAAGGATTTCGTCTTCCAGGGGAAGCTCAGAAAATCGATCGATTA
ATGGAAAAATTTGCTGCAAGATACCTAGAATGCAACCAAGGACAAACTCTCTTTGCTAGTGCGGATACAGCTTATGTTTTGGCTTATTCA
ATTATCATGTTGACCACAGACCTTCACAGTCCACAGGTGAAAAATAAAATGACAAAGGAACAATACATTAAGATGAATAGAGGTATCAAT
GACAGTAAAGACCTTCCTGAAGAGTATCTATCAGCCATCTATAATGAAATAGCTGGGAAAAAGATATCAATGAAAGAAACAAAAGAACTA
ACAATCCCTACAAAATCAAGTAAACAGAATGTAGCCAGTGAAAAACAAAGAAGACTTCTGTATAACTTAGAAATGGAGCAGATGGCCAAG
ACAGCTAAAGCACTCATGGAGGCCGTGAGCCATGTTCAGGCACCCTTTACAAGTGCAACACATTTGGAGCATGTGAGGCCCATGTTTAAG
GAAGACCTCTCTCTTTGCAAAAATCTTAGTGTTTTATATTTATATGATAATTGTATTAGTCAAATCACTAACCTGAATTATGCCACAAAT
CTGACCCACTTGTACCTACAAAACAATTGTATTTCATGTATAGAGAACCTCAGGTCATTAAAGAAACTGGAAAAACTGTATCTGGGAGGC
AATTACATTGCTGTCATAGAAGGTTTAGAAGGATTAGGAGAACTAAGAGAGCTTCATGTTGAGAATCAGAGGCTTCCCCTTGGGGAAAAG
CTTCTGTTTGATCCAAGAACTCTTCATTCTCTGGCAAAATCCCTCTGTATATTGAATATCAGCAATAATAATATTGATGACATTACAGAC
TTAGAACTACTAGAGAATCTTAATCAGCTCATAGCCGTTGACAACCAACTTCTGCATGTGAAGGATTTGGAGTTTTTACTGAACAAGTTG
ATGAAGCTGTGGAAAATTGATCTAAATGGAAATCCTGTTTGTCTCAAACCAAAATACAGGGACAGACTGATATTGGTGTCCAAATCACTG
GAATTTCTTGATGGAAAAGAAATTAAAAATATAGAAAGACAATTCCTAATGAATTGGAAAGCATCCAAAGATGCCAAGAAAATCAGCAAA
AAAAGGAGCAGTAAAAATGAGGATGCAAGCAATTCACTCATAAGTAACTTCAAAACAATGCATCATATAGTTCCTGTTTATTACCCACAG
GTGGGTAAGCCAAAATTAGCCTTTTTCTCTGAAATACAGAGATACCCTGTAAATGCAAATGCATCTCCAGAAAGTTCCTGAGAAGATTAC
ACTAAAATTATTTAAGAGATGGGGAATCTCTCTTTGAAGCAATCTGAAAGCTTGCTGACAAAAAATGATGTGCATGAACCTCACCTCTTC

>5859_5859_2_ARFGEF1-PPP1R42_ARFGEF1_chr8_68163534_ENST00000262215_PPP1R42_chr8_67926827_ENST00000522909_length(amino acids)=1216AA_BP=0
MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKAGSSTLPPVKSKTNFIEADKYFLPFELACQS
KCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYN
IYLASKNLINQTTAKATLTQMLNVIFARMENQALQEAKQMEKERHRQHHHLLQSPVSHHEPESPQLRYLPPQTVDHISQEHEGDLDLHTN
DVDKSLQDDTEPENGSDISSAENEQTEADQATAAETLSKNEVLYDGENHDCEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGT
IEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQKDAFLVFRSLCKLSMKPLSDGPPDPKSHEL
RSKILSLQLLLSILQNAGPIFRTNEMFINAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTS
SFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQ
YVNPNSQTTLGQEKPSEQEMSEIKHPETINRYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYL
QEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLE
CNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQN
VASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNC
ISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELLENLNQL
IAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPVCLKPKYRDRLILVSKSLEFLDGKEIKNIERQFLMNWKASKDAKKISKKRSSKNEDAS

--------------------------------------------------------------
>5859_5859_3_ARFGEF1-PPP1R42_ARFGEF1_chr8_68163534_ENST00000520381_PPP1R42_chr8_67926827_ENST00000324682_length(transcript)=2090nt_BP=1280nt
AGGTGTTCTTTAAAGAAATTTTCTTATACATTTTGGAAACTTCTACCAGCTCATTTGATCACAAATGGATGGTTATTCAGACACTGACGA
GGATTTGTGCAGATGCTCAGAGTGTAGTGGATATTTATGTAAACTATGACTGTGACTTAAATGCAGCCAATATATTTGAAAGACTAGTAA
ATGATCTATCAAAAATTGCTCAAGGAAGGGGCAGTCAAGAACTTGGTATGAGTAATGTTCAGGAATTGAGCCTGAGGAAAAAAGGTTTAG
AATGCTTAGTGTCGATTTTGAAGTGTATGGTTGAATGGAGTAAGGATCAGTATGTGAATCCCAACTCCCAGACAACTCTTGGTCAGGAAA
AACCCTCAGAGCAAGAGATGAGTGAAATCAAACACCCTGAGACAATAAACAGATACGGAAGTTTAAATTCCCTGGAGTCAACATCATCAT
CAGGAATAGGCAGCTACAGTACACAGATGTCTGGCACTGATAATCCAGAACAATTTGAGGTCCTAAAGCAACAAAAAGAAATAATAGAAC
AAGGGATAGATTTATTTAATAAGAAACCAAAGAGAGGAATACAGTACCTCCAAGAACAAGGGATGCTTGGCACCACACCTGAAGATATTG
CCCAATTCTTACATCAAGAGGAAAGATTAGACTCTACTCAAGTGGGTGAGTTCCTGGGAGATAATGATAAATTTAACAAAGAAGTCATGT
ATGCATATGTGGACCAACATGACTTTTCAGGAAAAGACTTCGTTTCAGCCCTTCGTATGTTTCTAGAAGGATTTCGTCTTCCAGGGGAAG
CTCAGAAAATCGATCGATTAATGGAAAAATTTGCTGCAAGATACCTAGAATGCAACCAAGGACAAACTCTCTTTGCTAGTGCGGATACAG
CTTATGTTTTGGCTTATTCAATTATCATGTTGACCACAGACCTTCACAGTCCACAGGTGAAAAATAAAATGACAAAGGAACAATACATTA
AGATGAATAGAGGTATCAATGACAGTAAAGACCTTCCTGAAGAGTATCTATCAGCCATCTATAATGAAATAGCTGGGAAAAAGATATCAA
TGAAAGAAACAAAAGAACTAACAATCCCTACAAAATCAAGTAAACAGAATGTAGCCAGTGAAAAACAAAGAAGACTTCTGTATAACTTAG
AAATGGAGCAGATGGCCAAGACAGCTAAAGCACTCATGGAGGCCGTGAGCCATGTTCAGGCACCCTTTACAAGTGCAACACATTTGGAGC
ATGTGAGGCCCATGTTTAAGGAAGACCTCTCTCTTTGCAAAAATCTTAGTGTTTTATATTTATATGATAATTGTATTAGTCAAATCACTA
ACCTGAATTATGCCACAAATCTGACCCACTTGTACCTACAAAACAATTGTATTTCATGTATAGAGAACCTCAGGTCATTAAAGAAACTGG
AAAAACTGTATCTGGGAGGCAATTACATTGCTGTCATAGAAGGTTTAGAAGGATTAGGAGAACTAAGAGAGCTTCATGTTGAGAATCAGA
GGCTTCCCCTTGGGGAAAAGCTTCTGTTTGATCCAAGAACTCTTCATTCTCTGGCAAAATCCCTCTGTATATTGAATATCAGCAATAATA
ATATTGATGACATTACAGACTTAGAACTACTAGAGAATCTTAATCAGCTCATAGCCGTTGACAACCAACTTCTGCATGTGAAGGATTTGG
AGTTTTTACTGAACAAGTTGATGAAGCTGTGGAAAATTGATCTAAATGGAAATCCTGTTTGTCTCAAACCAAAATACAGGGACAGACTGA
TATTGGTGTCCAAATCACTGGGTACATATTTATATTAATATAATTTTTAAGAGAATGACACCTAGTTAACTTTTTGGTTATTTTACCAGC
AAGCTTTCAGAAATATAAATCTGACATCTGGATCTGTGAAAATTGTCAACTTTAAATTCAATATTTTGAATAAGAGCAAAAGTTAAAATT
GACAAATAAAGCATGAAAAACATCTGCTGTTCAGAAGTAATTAAAGCACCTGATACTTATTCCTTAAGGAGGATATTTTGCTATTACCAA

>5859_5859_3_ARFGEF1-PPP1R42_ARFGEF1_chr8_68163534_ENST00000520381_PPP1R42_chr8_67926827_ENST00000324682_length(amino acids)=601AA_BP=1
METSTSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSILKCMV
EWSKDQYVNPNSQTTLGQEKPSEQEMSEIKHPETINRYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPK
RGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKF
AARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPT
KSSKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHL
YLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELL

--------------------------------------------------------------
>5859_5859_4_ARFGEF1-PPP1R42_ARFGEF1_chr8_68163534_ENST00000520381_PPP1R42_chr8_67926827_ENST00000522909_length(transcript)=2248nt_BP=1280nt
AGGTGTTCTTTAAAGAAATTTTCTTATACATTTTGGAAACTTCTACCAGCTCATTTGATCACAAATGGATGGTTATTCAGACACTGACGA
GGATTTGTGCAGATGCTCAGAGTGTAGTGGATATTTATGTAAACTATGACTGTGACTTAAATGCAGCCAATATATTTGAAAGACTAGTAA
ATGATCTATCAAAAATTGCTCAAGGAAGGGGCAGTCAAGAACTTGGTATGAGTAATGTTCAGGAATTGAGCCTGAGGAAAAAAGGTTTAG
AATGCTTAGTGTCGATTTTGAAGTGTATGGTTGAATGGAGTAAGGATCAGTATGTGAATCCCAACTCCCAGACAACTCTTGGTCAGGAAA
AACCCTCAGAGCAAGAGATGAGTGAAATCAAACACCCTGAGACAATAAACAGATACGGAAGTTTAAATTCCCTGGAGTCAACATCATCAT
CAGGAATAGGCAGCTACAGTACACAGATGTCTGGCACTGATAATCCAGAACAATTTGAGGTCCTAAAGCAACAAAAAGAAATAATAGAAC
AAGGGATAGATTTATTTAATAAGAAACCAAAGAGAGGAATACAGTACCTCCAAGAACAAGGGATGCTTGGCACCACACCTGAAGATATTG
CCCAATTCTTACATCAAGAGGAAAGATTAGACTCTACTCAAGTGGGTGAGTTCCTGGGAGATAATGATAAATTTAACAAAGAAGTCATGT
ATGCATATGTGGACCAACATGACTTTTCAGGAAAAGACTTCGTTTCAGCCCTTCGTATGTTTCTAGAAGGATTTCGTCTTCCAGGGGAAG
CTCAGAAAATCGATCGATTAATGGAAAAATTTGCTGCAAGATACCTAGAATGCAACCAAGGACAAACTCTCTTTGCTAGTGCGGATACAG
CTTATGTTTTGGCTTATTCAATTATCATGTTGACCACAGACCTTCACAGTCCACAGGTGAAAAATAAAATGACAAAGGAACAATACATTA
AGATGAATAGAGGTATCAATGACAGTAAAGACCTTCCTGAAGAGTATCTATCAGCCATCTATAATGAAATAGCTGGGAAAAAGATATCAA
TGAAAGAAACAAAAGAACTAACAATCCCTACAAAATCAAGTAAACAGAATGTAGCCAGTGAAAAACAAAGAAGACTTCTGTATAACTTAG
AAATGGAGCAGATGGCCAAGACAGCTAAAGCACTCATGGAGGCCGTGAGCCATGTTCAGGCACCCTTTACAAGTGCAACACATTTGGAGC
ATGTGAGGCCCATGTTTAAGGAAGACCTCTCTCTTTGCAAAAATCTTAGTGTTTTATATTTATATGATAATTGTATTAGTCAAATCACTA
ACCTGAATTATGCCACAAATCTGACCCACTTGTACCTACAAAACAATTGTATTTCATGTATAGAGAACCTCAGGTCATTAAAGAAACTGG
AAAAACTGTATCTGGGAGGCAATTACATTGCTGTCATAGAAGGTTTAGAAGGATTAGGAGAACTAAGAGAGCTTCATGTTGAGAATCAGA
GGCTTCCCCTTGGGGAAAAGCTTCTGTTTGATCCAAGAACTCTTCATTCTCTGGCAAAATCCCTCTGTATATTGAATATCAGCAATAATA
ATATTGATGACATTACAGACTTAGAACTACTAGAGAATCTTAATCAGCTCATAGCCGTTGACAACCAACTTCTGCATGTGAAGGATTTGG
AGTTTTTACTGAACAAGTTGATGAAGCTGTGGAAAATTGATCTAAATGGAAATCCTGTTTGTCTCAAACCAAAATACAGGGACAGACTGA
TATTGGTGTCCAAATCACTGGAATTTCTTGATGGAAAAGAAATTAAAAATATAGAAAGACAATTCCTAATGAATTGGAAAGCATCCAAAG
ATGCCAAGAAAATCAGCAAAAAAAGGAGCAGTAAAAATGAGGATGCAAGCAATTCACTCATAAGTAACTTCAAAACAATGCATCATATAG
TTCCTGTTTATTACCCACAGGTGGGTAAGCCAAAATTAGCCTTTTTCTCTGAAATACAGAGATACCCTGTAAATGCAAATGCATCTCCAG
AAAGTTCCTGAGAAGATTACACTAAAATTATTTAAGAGATGGGGAATCTCTCTTTGAAGCAATCTGAAAGCTTGCTGACAAAAAATGATG

>5859_5859_4_ARFGEF1-PPP1R42_ARFGEF1_chr8_68163534_ENST00000520381_PPP1R42_chr8_67926827_ENST00000522909_length(amino acids)=682AA_BP=1
METSTSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSILKCMV
EWSKDQYVNPNSQTTLGQEKPSEQEMSEIKHPETINRYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPK
RGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKF
AARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPT
KSSKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHL
YLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELL
ENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPVCLKPKYRDRLILVSKSLEFLDGKEIKNIERQFLMNWKASKDAKKISKKRSS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARFGEF1-PPP1R42


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARFGEF1-PPP1R42


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARFGEF1-PPP1R42


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource