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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EXOC5-SUCLA2 (FusionGDB2 ID:HG10640TG8803)

Fusion Gene Summary for EXOC5-SUCLA2

check button Fusion gene summary
Fusion gene informationFusion gene name: EXOC5-SUCLA2
Fusion gene ID: hg10640tg8803
HgeneTgene
Gene symbol

EXOC5

SUCLA2

Gene ID

10640

8803

Gene nameexocyst complex component 5succinate-CoA ligase ADP-forming subunit beta
SynonymsHSEC10|PRO1912|SEC10|SEC10L1|SEC10PA-BETA|A-SCS|LINC00444|MTDPS5|SCS-betaA
Cytomap('EXOC5')('SUCLA2')

14q22.3

13q14.2

Type of geneprotein-codingprotein-coding
Descriptionexocyst complex component 5SEC10-like 1exocyst complex component Sec10succinate--CoA ligase [ADP-forming] subunit beta, mitochondrialATP-specific succinyl-CoA synthetase subunit betaATP-specific succinyl-CoA synthetase, beta subunitlong intergenic non-protein coding RNA 444mitochondrial succinyl-CoA ligase [ADP-forming]
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000340918, ENST00000413566, 
ENST00000556911, 
Fusion gene scores* DoF score5 X 5 X 5=12511 X 12 X 6=792
# samples 511
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/792*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EXOC5 [Title/Abstract] AND SUCLA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEXOC5(57702428)-SUCLA2(48517580), # samples:1
Anticipated loss of major functional domain due to fusion event.EXOC5-SUCLA2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EXOC5-SUCLA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EXOC5-SUCLA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EXOC5-SUCLA2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across EXOC5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SUCLA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer173NEXOC5chr14

57702428

-SUCLA2chr13

48517580

-


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Fusion Gene ORF analysis for EXOC5-SUCLA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000340918ENST00000497202EXOC5chr14

57702428

-SUCLA2chr13

48517580

-
5CDS-intronENST00000413566ENST00000497202EXOC5chr14

57702428

-SUCLA2chr13

48517580

-
Frame-shiftENST00000340918ENST00000534875EXOC5chr14

57702428

-SUCLA2chr13

48517580

-
Frame-shiftENST00000340918ENST00000544100EXOC5chr14

57702428

-SUCLA2chr13

48517580

-
Frame-shiftENST00000413566ENST00000534875EXOC5chr14

57702428

-SUCLA2chr13

48517580

-
Frame-shiftENST00000413566ENST00000544100EXOC5chr14

57702428

-SUCLA2chr13

48517580

-
In-frameENST00000340918ENST00000378654EXOC5chr14

57702428

-SUCLA2chr13

48517580

-
In-frameENST00000340918ENST00000543413EXOC5chr14

57702428

-SUCLA2chr13

48517580

-
In-frameENST00000413566ENST00000378654EXOC5chr14

57702428

-SUCLA2chr13

48517580

-
In-frameENST00000413566ENST00000543413EXOC5chr14

57702428

-SUCLA2chr13

48517580

-
intron-3CDSENST00000556911ENST00000378654EXOC5chr14

57702428

-SUCLA2chr13

48517580

-
intron-3CDSENST00000556911ENST00000534875EXOC5chr14

57702428

-SUCLA2chr13

48517580

-
intron-3CDSENST00000556911ENST00000543413EXOC5chr14

57702428

-SUCLA2chr13

48517580

-
intron-3CDSENST00000556911ENST00000544100EXOC5chr14

57702428

-SUCLA2chr13

48517580

-
intron-intronENST00000556911ENST00000497202EXOC5chr14

57702428

-SUCLA2chr13

48517580

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000413566EXOC5chr1457702428-ENST00000378654SUCLA2chr1348517580-181910293601103247
ENST00000413566EXOC5chr1457702428-ENST00000543413SUCLA2chr1348517580-114110293601103247
ENST00000340918EXOC5chr1457702428-ENST00000378654SUCLA2chr1348517580-1515725251799182
ENST00000340918EXOC5chr1457702428-ENST00000543413SUCLA2chr1348517580-837725251799182

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000413566ENST00000378654EXOC5chr1457702428-SUCLA2chr1348517580-0.0012437570.9987563
ENST00000413566ENST00000543413EXOC5chr1457702428-SUCLA2chr1348517580-0.0032430660.996757
ENST00000340918ENST00000378654EXOC5chr1457702428-SUCLA2chr1348517580-0.0012513270.99874866
ENST00000340918ENST00000543413EXOC5chr1457702428-SUCLA2chr1348517580-0.0030839990.99691606

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Fusion Genomic Features for EXOC5-SUCLA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for EXOC5-SUCLA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:57702428/chr13:48517580)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEXOC5chr14:57702428chr13:48517580ENST00000413566-71840_101223709.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSUCLA2chr14:57702428chr13:48517580ENST0000037865491161_288439464.0DomainATP-grasp
TgeneSUCLA2chr14:57702428chr13:48517580ENST00000378654911105_107439464.0Nucleotide bindingATP
TgeneSUCLA2chr14:57702428chr13:48517580ENST00000378654911380_382439464.0RegionSubstrate binding%3B shared with subunit alpha


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Fusion Gene Sequence for EXOC5-SUCLA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>27931_27931_1_EXOC5-SUCLA2_EXOC5_chr14_57702428_ENST00000340918_SUCLA2_chr13_48517580_ENST00000378654_length(transcript)=1515nt_BP=725nt
ACTTCCGGCGTATGAGGCGGTGACAATGGGAGCAGCGCGGGCGGCGCCGGGAGGCAGCTGACAAGCGTTTGCGGCTTCGCTTCATGGCCG
CTCTCCCGCCCCTCCTGGGATCTGTGGGGAGCTGGGGAGCCCGCAGCGGCCCGGAGCCGGAGCTGGCGAGCCGAGCGGAGACCTGTGCGC
CGCGCCTCTGAGGCGCAGCATGTGAAGCGGAGACGGCATCCAGTGGGGGGCGAGCCTCTCAGCCGGCCGGGATGGCTACCACGGCCGAGC
TCTTCGAGGAGCCTTTTGTGGCAGATGAATATATTGAACGTCTTGTATGGAGAACCCCAGGAGGAGGCTCTAGAGGTGGACCTGAAGCTT
TTGATCCTAAAAGATTATTAGAAGAATTTGTAAATCATATTCAGGAACTCCAGATAATGGATGAAAGGATTCAGAGGAAAGTAGAGAAAC
TAGAGCAACAATGTCAGAAAGAAGCCAAGGAATTTGCCAAGAAGGTACAAGAGCTGCAGAAAAGCAATCAGATAAAGGAAGCAGCAGACA
TCATTCAGAAGTTGCACCTAATTGCCCAAGAGTTACCTTTTGATAGATTTTCAGAAGTTAAATCCAAAATTGCAAGTAAATACCATGATT
TAGAATGCCAGCTGATTCAGGAGTTTACCAGTGCTCAAAGAAGAGGTGAAATCTCCAGAATGAGAGAAGTAGCAGCAGTTTTACTTCATT
TTAAGGTTGTAAAGCTCTCTGAAATAGTGACCTTAGCGAAGCAAGCACATGTGGATGTGAAATTTCAGTTGCCAATATGATCTGAAAACC
CAGTGGATGGCTGAAGGTGTTAAATGTGCTATAATCATTAAGAATACTGTGTTCTGTGTTATTGTTCTTTTTCTTTTTAGTGTGTGGAGA
TTGTAATTGCCATCTAGGCACACAAACATTTAAAAGGATTTGGACTGCATTTAATTGTACCATTCAGAATGGACTGTTTGTACGAAGCAT
GTATAATGCAGTTATCTTCTTTCTTTTGTCGCAGCCAGTCTTTTTTGCTTCTCCTACAAAACGTAACTTGCAATTTGCCAGTTTATTATT
GTTGGATACAAAGTTCTTCATTGATAAGAGTCCTATAAATAAGATAAATACGAAGATAAAGCTTTATTCTTTAGTGTTAAAATACAGTAT
ATCTAATAACTAGCCTCATTAGTAGAGCAGTATATTAAAACAATGTTTTATGTAAAAAGTGTTTATCTTCAGCACCAAATACATGATAAA
TGTATCAATCACTATTTATAAACAGAGCTTTCAAACACTCCTCAGAATATTCTTCTAAGTATTTTGATGAAGTAACTTTGTAATTATTTG
AACATTGTTTTAATCATTAGGAAACACTGATTAACTGCAAGTCTTCATGATTCTGTCATATTAAGAAACACCTGTAGGTTTGCTTCAAAT

>27931_27931_1_EXOC5-SUCLA2_EXOC5_chr14_57702428_ENST00000340918_SUCLA2_chr13_48517580_ENST00000378654_length(amino acids)=182AA_BP=154
MATTAELFEEPFVADEYIERLVWRTPGGGSRGGPEAFDPKRLLEEFVNHIQELQIMDERIQRKVEKLEQQCQKEAKEFAKKVQELQKSNQ
IKEAADIIQKLHLIAQELPFDRFSEVKSKIASKYHDLECQLIQEFTSAQRRGEISRMREVAAVLLHFKVVKLSEIVTLAKQAHVDVKFQL

--------------------------------------------------------------
>27931_27931_2_EXOC5-SUCLA2_EXOC5_chr14_57702428_ENST00000340918_SUCLA2_chr13_48517580_ENST00000543413_length(transcript)=837nt_BP=725nt
ACTTCCGGCGTATGAGGCGGTGACAATGGGAGCAGCGCGGGCGGCGCCGGGAGGCAGCTGACAAGCGTTTGCGGCTTCGCTTCATGGCCG
CTCTCCCGCCCCTCCTGGGATCTGTGGGGAGCTGGGGAGCCCGCAGCGGCCCGGAGCCGGAGCTGGCGAGCCGAGCGGAGACCTGTGCGC
CGCGCCTCTGAGGCGCAGCATGTGAAGCGGAGACGGCATCCAGTGGGGGGCGAGCCTCTCAGCCGGCCGGGATGGCTACCACGGCCGAGC
TCTTCGAGGAGCCTTTTGTGGCAGATGAATATATTGAACGTCTTGTATGGAGAACCCCAGGAGGAGGCTCTAGAGGTGGACCTGAAGCTT
TTGATCCTAAAAGATTATTAGAAGAATTTGTAAATCATATTCAGGAACTCCAGATAATGGATGAAAGGATTCAGAGGAAAGTAGAGAAAC
TAGAGCAACAATGTCAGAAAGAAGCCAAGGAATTTGCCAAGAAGGTACAAGAGCTGCAGAAAAGCAATCAGATAAAGGAAGCAGCAGACA
TCATTCAGAAGTTGCACCTAATTGCCCAAGAGTTACCTTTTGATAGATTTTCAGAAGTTAAATCCAAAATTGCAAGTAAATACCATGATT
TAGAATGCCAGCTGATTCAGGAGTTTACCAGTGCTCAAAGAAGAGGTGAAATCTCCAGAATGAGAGAAGTAGCAGCAGTTTTACTTCATT
TTAAGGTTGTAAAGCTCTCTGAAATAGTGACCTTAGCGAAGCAAGCACATGTGGATGTGAAATTTCAGTTGCCAATATGATCTGAAAACC

>27931_27931_2_EXOC5-SUCLA2_EXOC5_chr14_57702428_ENST00000340918_SUCLA2_chr13_48517580_ENST00000543413_length(amino acids)=182AA_BP=154
MATTAELFEEPFVADEYIERLVWRTPGGGSRGGPEAFDPKRLLEEFVNHIQELQIMDERIQRKVEKLEQQCQKEAKEFAKKVQELQKSNQ
IKEAADIIQKLHLIAQELPFDRFSEVKSKIASKYHDLECQLIQEFTSAQRRGEISRMREVAAVLLHFKVVKLSEIVTLAKQAHVDVKFQL

--------------------------------------------------------------
>27931_27931_3_EXOC5-SUCLA2_EXOC5_chr14_57702428_ENST00000413566_SUCLA2_chr13_48517580_ENST00000378654_length(transcript)=1819nt_BP=1029nt
AAGGATCAAAGTTCCTCATACACGGTAGCGTCGAGCCTTTTTTCGGTTCTTTCGCCGCTCGTTTTATTCGCCGGCCCCTCCCGACAACCT
CCCTGGCGCGCGCAGTTCCACTTCCGGCGTATGAGGCGGTGACAATGGGAGCAGCGCGGGCGGCGCCGGGAGGCAGCTGACAAGCGTTTG
CGGCTTCGCTTCATGGCCGCTCTCCCGCCCCTCCTGGGATCTGTGGGGAGCTGGGGAGCCCGCAGCGGCCCGGAGCCGGAGCTGGCGAGC
CGAGCGGAGACCTGTGCGCCGCGCCTCTGAGGCGCAGCATGTGAAGCGGAGACGGCATCCAGTGGGGGGCGAGCCTCTCAGCCGGCCGGG
ATGGCTACCACGGCCGAGCTCTTCGAGGAGCCTTTTGTGGCAGATGAATATATTGAACGTCTTGTATGGAGAACCCCAGGAGGAGGCTCT
AGAGGTGGACCTGAAGCTTTTGATCCTAAAAGATTATTAGAAGAATTTGTAAATCATATTCAGGAACTCCAGATAATGGATGAAAGGATT
CAGAGGAAAGTAGAGAAACTAGAGCAACAATGTCAGAAAGAAGCCAAGGAATTTGCCAAGAAGGTACAAGAGCTGCAGAAAAGCAATCAG
GTTGCCTTCCAACATTTCCAAGAACTAGATGAGCACATTAGCTATGTAGCAACTAAAGTCTGTCACCTTGGAGACCAGTTAGAGGGGGTA
AACACACCCAGACAACGGGCAGTGGAGGCTCAGAAATTGATGAAATACTTTAATGAGTTTCTAGATGGAGAATTGAAATCTGATGTTTTT
ACAAATTCTGAAAAGATAAAGGAAGCAGCAGACATCATTCAGAAGTTGCACCTAATTGCCCAAGAGTTACCTTTTGATAGATTTTCAGAA
GTTAAATCCAAAATTGCAAGTAAATACCATGATTTAGAATGCCAGCTGATTCAGGAGTTTACCAGTGCTCAAAGAAGAGGTGAAATCTCC
AGAATGAGAGAAGTAGCAGCAGTTTTACTTCATTTTAAGGTTGTAAAGCTCTCTGAAATAGTGACCTTAGCGAAGCAAGCACATGTGGAT
GTGAAATTTCAGTTGCCAATATGATCTGAAAACCCAGTGGATGGCTGAAGGTGTTAAATGTGCTATAATCATTAAGAATACTGTGTTCTG
TGTTATTGTTCTTTTTCTTTTTAGTGTGTGGAGATTGTAATTGCCATCTAGGCACACAAACATTTAAAAGGATTTGGACTGCATTTAATT
GTACCATTCAGAATGGACTGTTTGTACGAAGCATGTATAATGCAGTTATCTTCTTTCTTTTGTCGCAGCCAGTCTTTTTTGCTTCTCCTA
CAAAACGTAACTTGCAATTTGCCAGTTTATTATTGTTGGATACAAAGTTCTTCATTGATAAGAGTCCTATAAATAAGATAAATACGAAGA
TAAAGCTTTATTCTTTAGTGTTAAAATACAGTATATCTAATAACTAGCCTCATTAGTAGAGCAGTATATTAAAACAATGTTTTATGTAAA
AAGTGTTTATCTTCAGCACCAAATACATGATAAATGTATCAATCACTATTTATAAACAGAGCTTTCAAACACTCCTCAGAATATTCTTCT
AAGTATTTTGATGAAGTAACTTTGTAATTATTTGAACATTGTTTTAATCATTAGGAAACACTGATTAACTGCAAGTCTTCATGATTCTGT
CATATTAAGAAACACCTGTAGGTTTGCTTCAAATAAAGGCATATATACCAAGGACTTACAGACAAAATTAAGAATGTCAATTTAAGTTAA

>27931_27931_3_EXOC5-SUCLA2_EXOC5_chr14_57702428_ENST00000413566_SUCLA2_chr13_48517580_ENST00000378654_length(amino acids)=247AA_BP=219
MATTAELFEEPFVADEYIERLVWRTPGGGSRGGPEAFDPKRLLEEFVNHIQELQIMDERIQRKVEKLEQQCQKEAKEFAKKVQELQKSNQ
VAFQHFQELDEHISYVATKVCHLGDQLEGVNTPRQRAVEAQKLMKYFNEFLDGELKSDVFTNSEKIKEAADIIQKLHLIAQELPFDRFSE

--------------------------------------------------------------
>27931_27931_4_EXOC5-SUCLA2_EXOC5_chr14_57702428_ENST00000413566_SUCLA2_chr13_48517580_ENST00000543413_length(transcript)=1141nt_BP=1029nt
AAGGATCAAAGTTCCTCATACACGGTAGCGTCGAGCCTTTTTTCGGTTCTTTCGCCGCTCGTTTTATTCGCCGGCCCCTCCCGACAACCT
CCCTGGCGCGCGCAGTTCCACTTCCGGCGTATGAGGCGGTGACAATGGGAGCAGCGCGGGCGGCGCCGGGAGGCAGCTGACAAGCGTTTG
CGGCTTCGCTTCATGGCCGCTCTCCCGCCCCTCCTGGGATCTGTGGGGAGCTGGGGAGCCCGCAGCGGCCCGGAGCCGGAGCTGGCGAGC
CGAGCGGAGACCTGTGCGCCGCGCCTCTGAGGCGCAGCATGTGAAGCGGAGACGGCATCCAGTGGGGGGCGAGCCTCTCAGCCGGCCGGG
ATGGCTACCACGGCCGAGCTCTTCGAGGAGCCTTTTGTGGCAGATGAATATATTGAACGTCTTGTATGGAGAACCCCAGGAGGAGGCTCT
AGAGGTGGACCTGAAGCTTTTGATCCTAAAAGATTATTAGAAGAATTTGTAAATCATATTCAGGAACTCCAGATAATGGATGAAAGGATT
CAGAGGAAAGTAGAGAAACTAGAGCAACAATGTCAGAAAGAAGCCAAGGAATTTGCCAAGAAGGTACAAGAGCTGCAGAAAAGCAATCAG
GTTGCCTTCCAACATTTCCAAGAACTAGATGAGCACATTAGCTATGTAGCAACTAAAGTCTGTCACCTTGGAGACCAGTTAGAGGGGGTA
AACACACCCAGACAACGGGCAGTGGAGGCTCAGAAATTGATGAAATACTTTAATGAGTTTCTAGATGGAGAATTGAAATCTGATGTTTTT
ACAAATTCTGAAAAGATAAAGGAAGCAGCAGACATCATTCAGAAGTTGCACCTAATTGCCCAAGAGTTACCTTTTGATAGATTTTCAGAA
GTTAAATCCAAAATTGCAAGTAAATACCATGATTTAGAATGCCAGCTGATTCAGGAGTTTACCAGTGCTCAAAGAAGAGGTGAAATCTCC
AGAATGAGAGAAGTAGCAGCAGTTTTACTTCATTTTAAGGTTGTAAAGCTCTCTGAAATAGTGACCTTAGCGAAGCAAGCACATGTGGAT

>27931_27931_4_EXOC5-SUCLA2_EXOC5_chr14_57702428_ENST00000413566_SUCLA2_chr13_48517580_ENST00000543413_length(amino acids)=247AA_BP=219
MATTAELFEEPFVADEYIERLVWRTPGGGSRGGPEAFDPKRLLEEFVNHIQELQIMDERIQRKVEKLEQQCQKEAKEFAKKVQELQKSNQ
VAFQHFQELDEHISYVATKVCHLGDQLEGVNTPRQRAVEAQKLMKYFNEFLDGELKSDVFTNSEKIKEAADIIQKLHLIAQELPFDRFSE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EXOC5-SUCLA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EXOC5-SUCLA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EXOC5-SUCLA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0023264Leigh Disease13CLINGEN
TgeneC1838951LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY13CLINGEN
TgeneC1850597Leigh Syndrome Due To Mitochondrial Complex II Deficiency13CLINGEN
TgeneC1850598Leigh Syndrome due to Mitochondrial Complex III Deficiency13CLINGEN
TgeneC1850599Leigh Syndrome due to Mitochondrial Complex IV Deficiency13CLINGEN
TgeneC1850600Leigh Syndrome due to Mitochondrial Complex V Deficiency13CLINGEN
TgeneC2931891Necrotizing encephalopathy, infantile subacute, of Leigh13CLINGEN
TgeneC2749864MITOCHONDRIAL DNA DEPLETION SYNDROME 5 (ENCEPHALOMYOPATHIC WITH OR WITHOUT METHYLMALONIC ACIDURIA)7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0028754Obesity1CTD_human