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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:CELF2-ZMYND11 (FusionGDB2 ID:HG10659TG10771)

Fusion Gene Summary for CELF2-ZMYND11

check button Fusion gene summary
Fusion gene informationFusion gene name: CELF2-ZMYND11
Fusion gene ID: hg10659tg10771
HgeneTgene
Gene symbol

CELF2

ZMYND11

Gene ID

10659

10771

Gene nameCUGBP Elav-like family member 2zinc finger MYND-type containing 11
SynonymsBRUNOL3|CELF-2|CUG-BP2|CUGBP2|ETR-3|ETR3|NAPORBRAM1|BS69|MRD30
Cytomap('CELF2')('ZMYND11')

10p14

10p15.3

Type of geneprotein-codingprotein-coding
DescriptionCUGBP Elav-like family member 2CUG triplet repeat RNA-binding protein 2CUG-BP- and ETR-3-like factor 2ELAV-type RNA-binding protein 3KDM2B/CELF2 fusionRNA-binding protein BRUNOL-3bruno-like protein 3neuroblastoma apoptosis-related RNA-binding protezinc finger MYND domain-containing protein 11adenovirus 5 E1A-binding proteinbone morphogenetic protein receptor-associated molecule 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000450189, ENST00000542579, 
ENST00000399850, ENST00000417956, 
ENST00000315874, ENST00000354440, 
ENST00000354897, ENST00000379261, 
ENST00000416382, ENST00000427450, 
ENST00000537122, ENST00000608830, 
ENST00000609692, 
Fusion gene scores* DoF score18 X 17 X 4=122410 X 8 X 7=560
# samples 2011
** MAII scorelog2(20/1224*10)=-2.61353165291793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/560*10)=-2.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CELF2 [Title/Abstract] AND ZMYND11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCELF2(11060126)-ZMYND11(225934), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCELF2

GO:0006376

mRNA splice site selection

11158314

TgeneZMYND11

GO:0051607

defense response to virus

26845565



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-A6-3810-01ACELF2chr10

11060126

+ZMYND11chr10

225934

+


Top

Fusion Gene ORF analysis for CELF2-ZMYND11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000450189ENST00000309776CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000450189ENST00000381584CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000450189ENST00000381591CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000450189ENST00000381602CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000450189ENST00000381604CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000450189ENST00000381607CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000450189ENST00000397959CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000450189ENST00000397962CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000450189ENST00000402736CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000450189ENST00000403354CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000450189ENST00000509513CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000450189ENST00000602682CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000542579ENST00000309776CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000542579ENST00000381584CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000542579ENST00000381591CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000542579ENST00000381602CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000542579ENST00000381604CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000542579ENST00000381607CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000542579ENST00000397959CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000542579ENST00000397962CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000542579ENST00000402736CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000542579ENST00000403354CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000542579ENST00000509513CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-5UTRENST00000542579ENST00000602682CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-intronENST00000450189ENST00000473115CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-intronENST00000450189ENST00000535374CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-intronENST00000450189ENST00000545619CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-intronENST00000450189ENST00000558098CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-intronENST00000542579ENST00000473115CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-intronENST00000542579ENST00000535374CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-intronENST00000542579ENST00000545619CELF2chr10

11060126

+ZMYND11chr10

225934

+
5CDS-intronENST00000542579ENST00000558098CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000399850ENST00000309776CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000399850ENST00000381584CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000399850ENST00000381591CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000399850ENST00000381602CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000399850ENST00000381604CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000399850ENST00000381607CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000399850ENST00000397959CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000399850ENST00000397962CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000399850ENST00000402736CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000399850ENST00000403354CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000399850ENST00000509513CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000399850ENST00000602682CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000417956ENST00000309776CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000417956ENST00000381584CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000417956ENST00000381591CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000417956ENST00000381602CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000417956ENST00000381604CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000417956ENST00000381607CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000417956ENST00000397959CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000417956ENST00000397962CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000417956ENST00000402736CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000417956ENST00000403354CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000417956ENST00000509513CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-5UTRENST00000417956ENST00000602682CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-intronENST00000399850ENST00000473115CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-intronENST00000399850ENST00000535374CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-intronENST00000399850ENST00000545619CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-intronENST00000399850ENST00000558098CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-intronENST00000417956ENST00000473115CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-intronENST00000417956ENST00000535374CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-intronENST00000417956ENST00000545619CELF2chr10

11060126

+ZMYND11chr10

225934

+
5UTR-intronENST00000417956ENST00000558098CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000315874ENST00000309776CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000315874ENST00000381584CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000315874ENST00000381591CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000315874ENST00000381602CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000315874ENST00000381604CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000315874ENST00000381607CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000315874ENST00000397959CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000315874ENST00000397962CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000315874ENST00000402736CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000315874ENST00000403354CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000315874ENST00000509513CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000315874ENST00000602682CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354440ENST00000309776CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354440ENST00000381584CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354440ENST00000381591CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354440ENST00000381602CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354440ENST00000381604CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354440ENST00000381607CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354440ENST00000397959CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354440ENST00000397962CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354440ENST00000402736CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354440ENST00000403354CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354440ENST00000509513CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354440ENST00000602682CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354897ENST00000309776CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354897ENST00000381584CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354897ENST00000381591CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354897ENST00000381602CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354897ENST00000381604CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354897ENST00000381607CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354897ENST00000397959CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354897ENST00000397962CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354897ENST00000402736CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354897ENST00000403354CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354897ENST00000509513CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000354897ENST00000602682CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000379261ENST00000309776CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000379261ENST00000381584CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000379261ENST00000381591CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000379261ENST00000381602CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000379261ENST00000381604CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000379261ENST00000381607CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000379261ENST00000397959CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000379261ENST00000397962CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000379261ENST00000402736CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000379261ENST00000403354CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000379261ENST00000509513CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000379261ENST00000602682CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000416382ENST00000309776CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000416382ENST00000381584CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000416382ENST00000381591CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000416382ENST00000381602CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000416382ENST00000381604CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000416382ENST00000381607CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000416382ENST00000397959CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000416382ENST00000397962CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000416382ENST00000402736CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000416382ENST00000403354CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000416382ENST00000509513CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000416382ENST00000602682CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000427450ENST00000309776CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000427450ENST00000381584CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000427450ENST00000381591CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000427450ENST00000381602CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000427450ENST00000381604CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000427450ENST00000381607CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000427450ENST00000397959CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000427450ENST00000397962CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000427450ENST00000402736CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000427450ENST00000403354CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000427450ENST00000509513CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000427450ENST00000602682CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000537122ENST00000309776CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000537122ENST00000381584CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000537122ENST00000381591CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000537122ENST00000381602CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000537122ENST00000381604CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000537122ENST00000381607CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000537122ENST00000397959CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000537122ENST00000397962CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000537122ENST00000402736CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000537122ENST00000403354CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000537122ENST00000509513CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000537122ENST00000602682CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000608830ENST00000309776CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000608830ENST00000381584CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000608830ENST00000381591CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000608830ENST00000381602CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000608830ENST00000381604CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000608830ENST00000381607CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000608830ENST00000397959CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000608830ENST00000397962CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000608830ENST00000402736CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000608830ENST00000403354CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000608830ENST00000509513CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000608830ENST00000602682CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000609692ENST00000309776CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000609692ENST00000381584CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000609692ENST00000381591CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000609692ENST00000381602CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000609692ENST00000381604CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000609692ENST00000381607CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000609692ENST00000397959CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000609692ENST00000397962CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000609692ENST00000402736CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000609692ENST00000403354CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000609692ENST00000509513CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-5UTRENST00000609692ENST00000602682CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000315874ENST00000473115CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000315874ENST00000535374CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000315874ENST00000545619CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000315874ENST00000558098CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000354440ENST00000473115CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000354440ENST00000535374CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000354440ENST00000545619CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000354440ENST00000558098CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000354897ENST00000473115CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000354897ENST00000535374CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000354897ENST00000545619CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000354897ENST00000558098CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000379261ENST00000473115CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000379261ENST00000535374CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000379261ENST00000545619CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000379261ENST00000558098CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000416382ENST00000473115CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000416382ENST00000535374CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000416382ENST00000545619CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000416382ENST00000558098CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000427450ENST00000473115CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000427450ENST00000535374CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000427450ENST00000545619CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000427450ENST00000558098CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000537122ENST00000473115CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000537122ENST00000535374CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000537122ENST00000545619CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000537122ENST00000558098CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000608830ENST00000473115CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000608830ENST00000535374CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000608830ENST00000545619CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000608830ENST00000558098CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000609692ENST00000473115CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000609692ENST00000535374CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000609692ENST00000545619CELF2chr10

11060126

+ZMYND11chr10

225934

+
intron-intronENST00000609692ENST00000558098CELF2chr10

11060126

+ZMYND11chr10

225934

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CELF2-ZMYND11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CELF2chr1011060126+ZMYND11chr10225932+3.40E-070.99999964
CELF2chr1011060126+ZMYND11chr10225932+3.40E-070.99999964


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CELF2-ZMYND11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:11060126/:225934)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CELF2-ZMYND11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CELF2-ZMYND11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CELF2-ZMYND11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CELF2-ZMYND11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCELF2C0014518Toxic Epidermal Necrolysis1CTD_human
HgeneCELF2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCELF2C0033578Prostatic Neoplasms1CTD_human
HgeneCELF2C0036341Schizophrenia1CTD_human
HgeneCELF2C0038325Stevens-Johnson Syndrome1CTD_human
HgeneCELF2C0376358Malignant neoplasm of prostate1CTD_human
HgeneCELF2C1274933Drug-Induced Stevens Johnson Syndrome1CTD_human
HgeneCELF2C3658301Mycoplasma-Induced Stevens-Johnson Syndrome1CTD_human
HgeneCELF2C3658302Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum1CTD_human
TgeneC3714756Intellectual Disability2GENOMICS_ENGLAND
TgeneC0004352Autistic Disorder1CTD_human