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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GNA13-TOM1 (FusionGDB2 ID:HG10672TG10043)

Fusion Gene Summary for GNA13-TOM1

check button Fusion gene summary
Fusion gene informationFusion gene name: GNA13-TOM1
Fusion gene ID: hg10672tg10043
HgeneTgene
Gene symbol

GNA13

TOM1

Gene ID

10672

10043

Gene nameG protein subunit alpha 13target of myb1 membrane trafficking protein
SynonymsG13-
Cytomap('GNA13')('TOM1')

17q24.1

22q12.3

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide-binding protein subunit alpha-13g alpha-13guanine nucleotide binding protein (G protein), alpha 13target of Myb protein 1target of myb 1
Modification date2020031320200313
UniProtAcc

Q14344

.
Ensembl transtripts involved in fusion geneENST00000439174, ENST00000541118, 
ENST00000439174, ENST00000541118, 
Fusion gene scores* DoF score11 X 4 X 9=39612 X 10 X 7=840
# samples 1615
** MAII scorelog2(16/396*10)=-1.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/840*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNA13 [Title/Abstract] AND TOM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGNA13(63049620)-TOM1(35713870), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-KB-A93J-01AGNA13chr17

63049620

-TOM1chr22

35713870

+
ChimerDB4STADTCGA-KB-A93JGNA13chr17

63049619

-TOM1chr22

35713869

+


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Fusion Gene ORF analysis for GNA13-TOM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000439174ENST00000382034GNA13chr17

63049620

-TOM1chr22

35713870

+
5CDS-5UTRENST00000439174ENST00000382034GNA13chr17

63049619

-TOM1chr22

35713869

+
5CDS-5UTRENST00000439174ENST00000411850GNA13chr17

63049620

-TOM1chr22

35713870

+
5CDS-5UTRENST00000439174ENST00000411850GNA13chr17

63049619

-TOM1chr22

35713869

+
5CDS-5UTRENST00000439174ENST00000425375GNA13chr17

63049620

-TOM1chr22

35713870

+
5CDS-5UTRENST00000439174ENST00000425375GNA13chr17

63049619

-TOM1chr22

35713869

+
5CDS-5UTRENST00000439174ENST00000436462GNA13chr17

63049620

-TOM1chr22

35713870

+
5CDS-5UTRENST00000439174ENST00000436462GNA13chr17

63049619

-TOM1chr22

35713869

+
5CDS-5UTRENST00000439174ENST00000447733GNA13chr17

63049620

-TOM1chr22

35713870

+
5CDS-5UTRENST00000439174ENST00000447733GNA13chr17

63049619

-TOM1chr22

35713869

+
5CDS-5UTRENST00000439174ENST00000449058GNA13chr17

63049620

-TOM1chr22

35713870

+
5CDS-5UTRENST00000439174ENST00000449058GNA13chr17

63049619

-TOM1chr22

35713869

+
5CDS-5UTRENST00000541118ENST00000382034GNA13chr17

63049620

-TOM1chr22

35713870

+
5CDS-5UTRENST00000541118ENST00000382034GNA13chr17

63049619

-TOM1chr22

35713869

+
5CDS-5UTRENST00000541118ENST00000411850GNA13chr17

63049620

-TOM1chr22

35713870

+
5CDS-5UTRENST00000541118ENST00000411850GNA13chr17

63049619

-TOM1chr22

35713869

+
5CDS-5UTRENST00000541118ENST00000425375GNA13chr17

63049620

-TOM1chr22

35713870

+
5CDS-5UTRENST00000541118ENST00000425375GNA13chr17

63049619

-TOM1chr22

35713869

+
5CDS-5UTRENST00000541118ENST00000436462GNA13chr17

63049620

-TOM1chr22

35713870

+
5CDS-5UTRENST00000541118ENST00000436462GNA13chr17

63049619

-TOM1chr22

35713869

+
5CDS-5UTRENST00000541118ENST00000447733GNA13chr17

63049620

-TOM1chr22

35713870

+
5CDS-5UTRENST00000541118ENST00000447733GNA13chr17

63049619

-TOM1chr22

35713869

+
5CDS-5UTRENST00000541118ENST00000449058GNA13chr17

63049620

-TOM1chr22

35713870

+
5CDS-5UTRENST00000541118ENST00000449058GNA13chr17

63049619

-TOM1chr22

35713869

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GNA13-TOM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GNA13chr1763049619-TOM1chr2235713869+1.26E-081
GNA13chr1763049619-TOM1chr2235713869+1.26E-081
GNA13chr1763049619-TOM1chr2235713869+1.26E-081
GNA13chr1763049619-TOM1chr2235713869+1.26E-081


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GNA13-TOM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:63049620/:35713870)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNA13

Q14344

.
FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333). {ECO:0000250|UniProtKB:P27601, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:12515866, ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:16705036, ECO:0000269|PubMed:16787920, ECO:0000269|PubMed:27084452}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GNA13-TOM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GNA13-TOM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GNA13-TOM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GNA13-TOM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGNA13C0006413Burkitt Lymphoma1CTD_human
HgeneGNA13C0343640African Burkitt's lymphoma1CTD_human
HgeneGNA13C4721444Burkitt Leukemia1CTD_human
TgeneC0005586Bipolar Disorder1PSYGENET
TgeneC1839839MAJOR AFFECTIVE DISORDER 21PSYGENET