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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GMEB1-EIF4G3 (FusionGDB2 ID:HG10691TG8672)

Fusion Gene Summary for GMEB1-EIF4G3

check button Fusion gene summary
Fusion gene informationFusion gene name: GMEB1-EIF4G3
Fusion gene ID: hg10691tg8672
HgeneTgene
Gene symbol

GMEB1

EIF4G3

Gene ID

10691

8672

Gene nameglucocorticoid modulatory element binding protein 1eukaryotic translation initiation factor 4 gamma 3
SynonymsP96PIF|PIF96eIF-4G 3|eIF4G 3|eIF4GII
Cytomap('GMEB1')('EIF4G3')

1p35.3

1p36.12

Type of geneprotein-codingprotein-coding
Descriptionglucocorticoid modulatory element-binding protein 1DNA-binding protein p96PIFPIF p96parvovirus initiation factor p96eukaryotic translation initiation factor 4 gamma 3eIF-4-gamma 3eIF-4-gamma II
Modification date2020032020200313
UniProtAcc

Q9Y692

O43432

Ensembl transtripts involved in fusion geneENST00000480454, ENST00000294409, 
ENST00000361872, ENST00000373816, 
Fusion gene scores* DoF score7 X 7 X 6=29425 X 20 X 9=4500
# samples 1230
** MAII scorelog2(12/294*10)=-1.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/4500*10)=-3.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GMEB1 [Title/Abstract] AND EIF4G3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGMEB1(29023596)-EIF4G3(21167521), # samples:1
Anticipated loss of major functional domain due to fusion event.GMEB1-EIF4G3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
GMEB1-EIF4G3 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
GMEB1-EIF4G3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-BK-A26L-01CGMEB1chr1

29023596

+EIF4G3chr1

21167521

-


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Fusion Gene ORF analysis for GMEB1-EIF4G3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000480454ENST00000264211GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
3UTR-3CDSENST00000480454ENST00000374935GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
3UTR-3CDSENST00000480454ENST00000374937GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
3UTR-3CDSENST00000480454ENST00000400422GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
3UTR-3CDSENST00000480454ENST00000536266GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
3UTR-3CDSENST00000480454ENST00000602326GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
3UTR-intronENST00000480454ENST00000356916GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
3UTR-intronENST00000480454ENST00000374927GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
3UTR-intronENST00000480454ENST00000374933GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
3UTR-intronENST00000480454ENST00000537738GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
3UTR-intronENST00000480454ENST00000544689GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
5CDS-intronENST00000294409ENST00000356916GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
5CDS-intronENST00000294409ENST00000374927GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
5CDS-intronENST00000294409ENST00000374933GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
5CDS-intronENST00000294409ENST00000537738GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
5CDS-intronENST00000294409ENST00000544689GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
5CDS-intronENST00000361872ENST00000356916GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
5CDS-intronENST00000361872ENST00000374927GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
5CDS-intronENST00000361872ENST00000374933GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
5CDS-intronENST00000361872ENST00000537738GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
5CDS-intronENST00000361872ENST00000544689GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
5CDS-intronENST00000373816ENST00000356916GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
5CDS-intronENST00000373816ENST00000374927GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
5CDS-intronENST00000373816ENST00000374933GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
5CDS-intronENST00000373816ENST00000537738GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
5CDS-intronENST00000373816ENST00000544689GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
Frame-shiftENST00000294409ENST00000264211GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
Frame-shiftENST00000294409ENST00000374935GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
Frame-shiftENST00000294409ENST00000374937GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
Frame-shiftENST00000294409ENST00000400422GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
Frame-shiftENST00000294409ENST00000536266GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
Frame-shiftENST00000294409ENST00000602326GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
Frame-shiftENST00000361872ENST00000264211GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
Frame-shiftENST00000361872ENST00000374935GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
Frame-shiftENST00000361872ENST00000374937GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
Frame-shiftENST00000361872ENST00000400422GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
Frame-shiftENST00000361872ENST00000536266GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
Frame-shiftENST00000361872ENST00000602326GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
Frame-shiftENST00000373816ENST00000264211GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
Frame-shiftENST00000373816ENST00000374935GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
Frame-shiftENST00000373816ENST00000374937GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
Frame-shiftENST00000373816ENST00000400422GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
Frame-shiftENST00000373816ENST00000536266GMEB1chr1

29023596

+EIF4G3chr1

21167521

-
Frame-shiftENST00000373816ENST00000602326GMEB1chr1

29023596

+EIF4G3chr1

21167521

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GMEB1-EIF4G3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for GMEB1-EIF4G3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:29023596/:21167521)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GMEB1

Q9Y692

EIF4G3

O43432

FUNCTION: Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.FUNCTION: Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1. {ECO:0000269|PubMed:9418880}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GMEB1-EIF4G3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GMEB1-EIF4G3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GMEB1-EIF4G3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GMEB1-EIF4G3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource