![]() |
||||||
|
![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ADCY2-HSDL2 (FusionGDB2 ID:HG108TG84263) |
Fusion Gene Summary for ADCY2-HSDL2 |
![]() |
Fusion gene information | Fusion gene name: ADCY2-HSDL2 | Fusion gene ID: hg108tg84263 | Hgene | Tgene | Gene symbol | ADCY2 | HSDL2 | Gene ID | 108 | 84263 |
Gene name | adenylate cyclase 2 | hydroxysteroid dehydrogenase like 2 | |
Synonyms | AC2|HBAC2 | C9orf99|SDR13C1 | |
Cytomap | ('ADCY2')('HSDL2') 5p15.31 | 9q32 | |
Type of gene | protein-coding | protein-coding | |
Description | adenylate cyclase type 23',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 2adenylate cyclase 2 (brain)adenylate cyclase IIadenylate cyclase type IIadenylyl cyclase 2type II adenylate cyclase | hydroxysteroid dehydrogenase-like protein 2short chain dehydrogenase/reductase family 13C member 1 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000338316, ENST00000537121, ENST00000513693, | ||
Fusion gene scores | * DoF score | 11 X 9 X 6=594 | 6 X 6 X 6=216 |
# samples | 10 | 7 | |
** MAII score | log2(10/594*10)=-2.57046293102604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/216*10)=-1.6256044852185 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ADCY2 [Title/Abstract] AND HSDL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ADCY2(7773214)-HSDL2(115179121), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | ADCY2-HSDL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADCY2-HSDL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADCY2-HSDL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ADCY2-HSDL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
![]() |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
![]() |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SARC | TCGA-DX-A1KZ-01A | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
Top |
Fusion Gene ORF analysis for ADCY2-HSDL2 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000338316 | ENST00000262542 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
5CDS-3UTR | ENST00000338316 | ENST00000488101 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
5CDS-3UTR | ENST00000537121 | ENST00000262542 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
5CDS-3UTR | ENST00000537121 | ENST00000488101 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
5CDS-intron | ENST00000338316 | ENST00000398803 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
5CDS-intron | ENST00000338316 | ENST00000539114 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
5CDS-intron | ENST00000537121 | ENST00000398803 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
5CDS-intron | ENST00000537121 | ENST00000539114 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
In-frame | ENST00000338316 | ENST00000398805 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
In-frame | ENST00000537121 | ENST00000398805 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
intron-3CDS | ENST00000513693 | ENST00000398805 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
intron-3UTR | ENST00000513693 | ENST00000262542 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
intron-3UTR | ENST00000513693 | ENST00000488101 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
intron-intron | ENST00000513693 | ENST00000398803 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
intron-intron | ENST00000513693 | ENST00000539114 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000338316 | ADCY2 | chr5 | 7773214 | + | ENST00000398805 | HSDL2 | chr9 | 115179121 | + | 5201 | 2473 | 89 | 3334 | 1081 |
ENST00000537121 | ADCY2 | chr5 | 7773214 | + | ENST00000398805 | HSDL2 | chr9 | 115179121 | + | 4638 | 1910 | 66 | 2771 | 901 |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000338316 | ENST00000398805 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + | 0.00027331 | 0.9997267 |
ENST00000537121 | ENST00000398805 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + | 0.000238572 | 0.9997614 |
Top |
Fusion Genomic Features for ADCY2-HSDL2 |
![]() |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179120 | + | 9.67E-06 | 0.99999034 |
ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179120 | + | 9.67E-06 | 0.99999034 |
![]() |
![]() |
![]() |
![]() |
Top |
Fusion Protein Features for ADCY2-HSDL2 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:7773214/chr9:115179121) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
![]() |
![]() |
Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 295_300 | 794 | 1092.0 | Nucleotide binding | ATP |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 337_339 | 794 | 1092.0 | Nucleotide binding | ATP |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 1_45 | 794 | 1092.0 | Topological domain | Cytoplasmic |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 208_601 | 794 | 1092.0 | Topological domain | Cytoplasmic |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 108_128 | 794 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 133_153 | 794 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 159_179 | 794 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 187_207 | 794 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 46_66 | 794 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 602_622 | 794 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 628_652 | 794 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 680_701 | 794 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 734_755 | 794 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 763_780 | 794 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 76_96 | 794 | 1092.0 | Transmembrane | Helical |
Tgene | HSDL2 | chr5:7773214 | chr9:115179121 | ENST00000398803 | 0 | 9 | 306_415 | 0 | 346.0 | Domain | Note=SCP2 | |
Tgene | HSDL2 | chr5:7773214 | chr9:115179121 | ENST00000398805 | 3 | 11 | 306_415 | 131 | 419.0 | Domain | Note=SCP2 | |
Tgene | HSDL2 | chr5:7773214 | chr9:115179121 | ENST00000398803 | 0 | 9 | 17_23 | 0 | 346.0 | Nucleotide binding | NADP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 1019_1021 | 794 | 1092.0 | Nucleotide binding | ATP |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 1026_1030 | 794 | 1092.0 | Nucleotide binding | ATP |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 822_1091 | 794 | 1092.0 | Topological domain | Cytoplasmic |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 801_821 | 794 | 1092.0 | Transmembrane | Helical |
Tgene | HSDL2 | chr5:7773214 | chr9:115179121 | ENST00000398805 | 3 | 11 | 17_23 | 131 | 419.0 | Nucleotide binding | NADP |
Top |
Fusion Gene Sequence for ADCY2-HSDL2 |
![]() |
>2217_2217_1_ADCY2-HSDL2_ADCY2_chr5_7773214_ENST00000338316_HSDL2_chr9_115179121_ENST00000398805_length(transcript)=5201nt_BP=2473nt AGGCGGCGCGGGGGTGGGACGCGGGCGGCCGCGGCGAGCGGCGCTGCCCGGGCCGGGCGCGCACGGCGGGCGCCCTGTGAGCGGCCCCGA TGTGGCAGGAGGCGATGCGGCGCCGCCGCTACCTGCGGGACCGCTCCGAGGAGGCGGCGGGCGGCGGAGACGGGCTGCCGCGGTCCCGGG ACTGGCTCTACGAGTCCTACTACTGCATGAGCCAGCAGCACCCGCTCATCGTCTTCCTGCTGCTCATCGTCATGGGCTCCTGCCTCGCCC TGCTCGCCGTCTTCTTCGCGCTCGGGCTGGAAGTTGAAGACCATGTGGCGTTTCTAATAACAGTTCCAACTGCCCTGGCGATTTTCTTTG CGATATTTATCCTGGTCTGCATCGAGTCTGTGTTTAAGAAGCTGCTGCGCCTCTTCTCGTTGGTGATATGGATATGCCTTGTTGCCATGG GATACCTGTTCATGTGTTTTGGAGGCACCGTCTCTCCCTGGGACCAGGTATCGTTCTTCCTCTTCATCATCTTCGTGGTGTACACCATGC TGCCCTTCAACATGCGAGACGCCATCATTGCCAGCGTCCTCACCTCCTCCTCCCACACCATCGTGCTTAGCGTCTGCCTGTCTGCAACAC CGGGAGGCAAGGAGCACCTGGTCTGGCAGATCCTGGCCAATGTGATCATTTTCATCTGTGGGAACCTGGCGGGAGCCTACCATAAGCACC TCATGGAACTCGCTCTTCAGCAAACATATCAGGACACCTGTAATTGCATCAAGTCGCGGATCAAGTTGGAATTTGAAAAACGTCAACAGG AGCGGCTTCTGCTCTCCCTGCTGCCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGCC AGATGGAGAACACAAATAACTTCCACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACCC GGCTGGCAAGTGACTGCTCCCCGGGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAAT GCATGAGAATTAAAATTTTAGGAGACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAAA TGGGGCTGGACATGTGTGAAGCCATAAAGAAAGTGAGGGATGCTACTGGAGTTGATATCAACATGCGCGTGGGCGTGCATTCTGGGAATG TCCTGTGTGGCGTGATTGGTCTGCAGAAGTGGCAATATGATGTGTGGTCACATGATGTGACCTTGGCCAACCACATGGAAGCTGGAGGGG TCCCTGGACGTGTTCACATTTCTTCTGTCACCCTGGAGCACTTGAATGGCGCTTATAAAGTGGAGGAGGGAGATGGTGACATTAGGGACC CATATTTAAAACAGCACCTGGTGAAAACCTACTTTGTGATCAACCCCAAGGGAGAACGACGGAGCCCCCAGCATCTCTTCAGACCTCGCC ACACCCTTGATGGAGCCAAAATGAGGGCCTCGGTCCGCATGACCCGGTACTTGGAGTCCTGGGGGGCAGCCAAGCCCTTTGCACACCTAC ATCACAGGGACAGCATGACCACAGAGAACGGCAAGATCAGCACCACGGATGTACCCATGGGTCAGCATAATTTTCAAAATCGCACCTTAA GAACCAAGTCACAAAAGAAGAGATTTGAAGAAGAATTGAATGAAAGGATGATTCAAGCAATTGATGGGATTAATGCACAGAAGCAATGGC TCAAGTCTGAAGACATTCAGAGAATCTCACTGCTTTTCTATAACAAAGTACTAGAAAAAGAGTACCGGGCCACGGCACTGCCAGCGTTCA AGTATTATGTGACTTGTGCCTGTCTCATATTCTTCTGCATCTTCATTGTGCAGATTCTCGTGCTGCCAAAAACGTCCGTCCTGGGCATCT CCTTTGGGGCTGCGTTTCTCTTGCTGGCCTTCATCCTCTTCGTCTGCTTTGCTGGACAGCTTCTGCAATGCAGCAAAAAAGCCTCTCCCC TGCTCATGTGGCTTTTGAAGTCCTCGGGCATCATTGCCAACCGCCCCTGGCCACGGATCTCTCTCACGATCATCACCACAGCCATCATAT TAATGATGGCCGTGTTCAACATGTTTTTCCTGAGTGACTCAGAGGAAACAATCCCTCCAACTGCCAACACAACAAACACAAGCTTTTCAG CCTCAAATAATCAGGTGGCGATTCTGCGTGCGCAGAATTTATTTTTCCTCCCGTACTTTATCTACAGCTGCATTCTGGGACTGATATCCT GTTCCGTGTTCCTGCGGGTAAACTATGAGCTGAAGATGTTGATCATGATGGTGGCCTTGGTGGGCTACAACACCATCCTACTCCACACCC ACGCCCACGTCCTGGGCGACTACAGCCAGGTCTTATTTGAGAGATCTAAAGCATGTATTCCTTATTTGAAAAAGAGCAAAGTTGCTCATA TCCTCAATATCAGTCCACCACTGAACCTAAATCCAGTTTGGTTCAAACAGCACTGTGCTTATACCATTGCTAAGTATGGTATGTCTATGT ATGTGCTTGGAATGGCAGAAGAATTTAAAGGTGAAATTGCAGTCAATGCATTATGGCCTAAAACAGCCATACACACTGCTGCTATGGATA TGCTGGGAGGACCTGGTATCGAAAGCCAGTGTAGAAAAGTTGATATCATTGCAGATGCAGCATATTCCATTTTCCAAAAGCCAAAAAGTT TTACTGGCAACTTTGTCATTGATGAAAATATCTTAAAAGAAGAAGGAATAGAAAATTTTGACGTTTATGCAATTAAACCAGGTCATCCTT TGCAACCAGATTTCTTCTTAGATGAATACCCAGAAGCAGTTAGCAAGAAAGTGGAATCAACTGGTGCTGTTCCAGAATTCAAAGAAGAGA AACTGCAGCTGCAACCAAAACCACGTTCTGGAGCTGTGGAAGAAACATTTAGAATTGTTAAGGACTCTCTCAGTGATGATGTTGTTAAAG CCACTCAAGCAATCTATCTGTTTGAACTCTCCGGTGAAGATGGTGGCACGTGGTTTCTTGATCTGAAAAGCAAGGGTGGGAATGTCGGAT ATGGAGAGCCTTCTGATCAGGCAGATGTGGTGATGAGTATGACTACTGATGACTTTGTAAAAATGTTTTCAGGGAAACTAAAACCAACAA TGGCATTCATGTCAGGGAAATTGAAGATTAAAGGTAACATGGCCCTAGCAATCAAATTGGAGAAGCTAATGAATCAGATGAATGCCAGAC TGTGAAGGAAAATATAAAAAAAAAGTCGACTGCTATGCTCAAAAAGTAAAAAAAGCTCAACAGTTAAAATCTAATGTTTGTTTTCTTTCC TGTTATATTATAAGGATATGCACGTTTGTTCTGGAAAAGATAGAATTTGTCTCTAAAAGACTTGAAATTGTAATTAAAATGGCAAGCTAA TCAAACATAAGCTTCATTAAGTGGGATTCTAAGACAGTCTGTGTTTTTATATTTCAAGGGTTTAACCCTTTGAGCCTTACATCTCATTCA CTGTCTTTCTCCAAGAAAAGTATTTTGGGCGGACAGTCAGATCAAGCAGTAAAATTAGCTCTTTCAAATCTTCTTGTCATGTAAAATGAA GCTAGTCTGTTTTAAAATTTTTAGTTTTGGATTGTATACTAATGAAAATCTTAATGATGTTTTTGATTTTTATATACTTATTTTAAAGAA AATCTTATATAGTACATTTTACAAAAATTATAAAAAATGAATTAGTACTGGCGAGGACTAAATGAAACAATAATTTTTCATTTTGATAAC TAGCTTTCCAGGTGGACTTAGCCATAGGAAAATATTACTAATGTAATTTAACAAATTGCTGCATGTATTCCATTTAAAAATATGTTTAAA TTGTCCTAAAACAAAATAATTTTCTCCCTAGGAGTATGCATTTGGCTACAGTGTTTTGAAACAGAAACCTTAGAATAGGTCATTGGTATG GGCTGAACTGTGTATCCCCCAATTCATTTGTTGAGGTCCTAACTCCCATTTCTTTTGAATGTGACTGTTCGGAGATGAGGCCTTTAAAGA GGTGACTTAAGTTCAAAGGAGGCTGTTAGTCTAATCCAACATGGTGTCCTTTGGACATAAGAGATACCAGCAATGTGTGCACAGAACAAA GACCAGGAGAGGACACAGTGAGAAGGCAGTTATCTGCAAGCAAAGAGAGAGGCTTCAGAAGAAACAAAATCACCAGCACCTTGATCTTTG ACTTCTAATCTCCAGAATAGTGAGAAATAAATTTCTGTTGTTAAGCCGTCCACTGTGGGAGGCCGACGCAGGAGGATTGCTTGAGGCCAG GAGTTCAAGGCCAGCCTGGACAACATAGTAAGACCCTATCTCTACCCCCCTAATAAATTAATTTAAAAAGCCCCCCAATCTGTGGTATTT TATTATGGCAGCCCTAGCAAGCTAATACAGTGGTTTGAGAGGCTGGGAGGGTTGAGGGGAAGATAAACTTTTAAAAAGCTCTTATCTTTC ATTTCAATCAGTTAAAAATACTTGCTCAGTGTAACAATTTTGCTTCTCAGCTTCCACTCTAATATTGTTGTGCCATTAAGCAATTTAGCT AATCCTGACATTTCTTAGATTCATAATGTTAGGAGCATTTAATCTGTATTTTACAAGTTAGGAAGCAGAGGATCAGAGATGGGAAAGGAC TAGCCCAAGGCCAACATTAACAAGCCCTCTAACAAAAACTTTACAATACATTTATGTTGAATGGAACTCCAAGATCTCACCTCTCCATCC AGGAATGGAGTCCATGTAATCAAAGTGAACTTAAAAATAGGACAGTTTCAACAAGTCAGGAGATTCACAGCAACTGATCAAAGGGAGTCC AGTCAACGTGAGCAAGCGTGATTATGATGAGGAAGCCCCCTCTGCTTTAATCCACACAAGGAACGTAACCTGAAGTAACCTGATGTTAAC CAATCTGCTGTGTCTACTATGCTGTTTCCTTGTTCCTGCTAGTGCTGCTTTACAAATGCAGACCATTCTATCATACCTGGCGGGGCTTCT >2217_2217_1_ADCY2-HSDL2_ADCY2_chr5_7773214_ENST00000338316_HSDL2_chr9_115179121_ENST00000398805_length(amino acids)=1081AA_BP=794 MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFF AIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSAT PGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAG QMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRD PYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL RTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGI SFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFS ASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERSKACIPYLKKSKVAH ILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVLGMAEEFKGEIAVNALWPKTAIHTAAMDMLGGPGIESQCRKVDIIADAAYSIFQKPKS FTGNFVIDENILKEEGIENFDVYAIKPGHPLQPDFFLDEYPEAVSKKVESTGAVPEFKEEKLQLQPKPRSGAVEETFRIVKDSLSDDVVK ATQAIYLFELSGEDGGTWFLDLKSKGGNVGYGEPSDQADVVMSMTTDDFVKMFSGKLKPTMAFMSGKLKIKGNMALAIKLEKLMNQMNAR -------------------------------------------------------------- >2217_2217_2_ADCY2-HSDL2_ADCY2_chr5_7773214_ENST00000537121_HSDL2_chr9_115179121_ENST00000398805_length(transcript)=4638nt_BP=1910nt GAGGAGTTTGGTAGAAATCCCAGAAGAGCTGTTGAGAAGACCAGTGGAGCCACACGTCTAGAGGTCATGGACCTGCGCTGGGCCAGAGAT CTGCATTTGAGAGAAGCCAGCAGATCAGTAGCATTTACCACCCTGAGGCTGGGCGCAGTCACCACGGGACTCCTGACATTCAGAGAGCCA GGAGATAAAGAGAAGTCAGGAAAGGGCCTTGGGAAGAGATGGCGCATCCAGCGAGAGGAAAGCCAGGAGCGGCTTCTGCTCTCCCTGCTG CCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGCCAGATGGAGAACACAAATAACTTC CACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACCCGGCTGGCAAGTGACTGCTCCCCG GGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAATGCATGAGAATTAAAATTTTAGGA GACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAAATGGGGCTGGACATGTGTGAAGCC ATAAAGAAAGTGAGGGATGCTACTGGAGTTGATATCAACATGCGCGTGGGCGTGCATTCTGGGAATGTCCTGTGTGGCGTGATTGGTCTG CAGAAGTGGCAATATGATGTGTGGTCACATGATGTGACCTTGGCCAACCACATGGAAGCTGGAGGGGTCCCTGGACGTGTTCACATTTCT TCTGTCACCCTGGAGCACTTGAATGGCGCTTATAAAGTGGAGGAGGGAGATGGTGACATTAGGGACCCATATTTAAAACAGCACCTGGTG AAAACCTACTTTGTGATCAACCCCAAGGGAGAACGACGGAGCCCCCAGCATCTCTTCAGACCTCGCCACACCCTTGATGGAGCCAAAATG AGGGCCTCGGTCCGCATGACCCGGTACTTGGAGTCCTGGGGGGCAGCCAAGCCCTTTGCACACCTACATCACAGGGACAGCATGACCACA GAGAACGGCAAGATCAGCACCACGGATGTACCCATGGGTCAGCATAATTTTCAAAATCGCACCTTAAGAACCAAGTCACAAAAGAAGAGA TTTGAAGAAGAATTGAATGAAAGGATGATTCAAGCAATTGATGGGATTAATGCACAGAAGCAATGGCTCAAGTCTGAAGACATTCAGAGA ATCTCACTGCTTTTCTATAACAAAGTACTAGAAAAAGAGTACCGGGCCACGGCACTGCCAGCGTTCAAGTATTATGTGACTTGTGCCTGT CTCATATTCTTCTGCATCTTCATTGTGCAGATTCTCGTGCTGCCAAAAACGTCCGTCCTGGGCATCTCCTTTGGGGCTGCGTTTCTCTTG CTGGCCTTCATCCTCTTCGTCTGCTTTGCTGGACAGCTTCTGCAATGCAGCAAAAAAGCCTCTCCCCTGCTCATGTGGCTTTTGAAGTCC TCGGGCATCATTGCCAACCGCCCCTGGCCACGGATCTCTCTCACGATCATCACCACAGCCATCATATTAATGATGGCCGTGTTCAACATG TTTTTCCTGAGTGACTCAGAGGAAACAATCCCTCCAACTGCCAACACAACAAACACAAGCTTTTCAGCCTCAAATAATCAGGTGGCGATT CTGCGTGCGCAGAATTTATTTTTCCTCCCGTACTTTATCTACAGCTGCATTCTGGGACTGATATCCTGTTCCGTGTTCCTGCGGGTAAAC TATGAGCTGAAGATGTTGATCATGATGGTGGCCTTGGTGGGCTACAACACCATCCTACTCCACACCCACGCCCACGTCCTGGGCGACTAC AGCCAGGTCTTATTTGAGAGATCTAAAGCATGTATTCCTTATTTGAAAAAGAGCAAAGTTGCTCATATCCTCAATATCAGTCCACCACTG AACCTAAATCCAGTTTGGTTCAAACAGCACTGTGCTTATACCATTGCTAAGTATGGTATGTCTATGTATGTGCTTGGAATGGCAGAAGAA TTTAAAGGTGAAATTGCAGTCAATGCATTATGGCCTAAAACAGCCATACACACTGCTGCTATGGATATGCTGGGAGGACCTGGTATCGAA AGCCAGTGTAGAAAAGTTGATATCATTGCAGATGCAGCATATTCCATTTTCCAAAAGCCAAAAAGTTTTACTGGCAACTTTGTCATTGAT GAAAATATCTTAAAAGAAGAAGGAATAGAAAATTTTGACGTTTATGCAATTAAACCAGGTCATCCTTTGCAACCAGATTTCTTCTTAGAT GAATACCCAGAAGCAGTTAGCAAGAAAGTGGAATCAACTGGTGCTGTTCCAGAATTCAAAGAAGAGAAACTGCAGCTGCAACCAAAACCA CGTTCTGGAGCTGTGGAAGAAACATTTAGAATTGTTAAGGACTCTCTCAGTGATGATGTTGTTAAAGCCACTCAAGCAATCTATCTGTTT GAACTCTCCGGTGAAGATGGTGGCACGTGGTTTCTTGATCTGAAAAGCAAGGGTGGGAATGTCGGATATGGAGAGCCTTCTGATCAGGCA GATGTGGTGATGAGTATGACTACTGATGACTTTGTAAAAATGTTTTCAGGGAAACTAAAACCAACAATGGCATTCATGTCAGGGAAATTG AAGATTAAAGGTAACATGGCCCTAGCAATCAAATTGGAGAAGCTAATGAATCAGATGAATGCCAGACTGTGAAGGAAAATATAAAAAAAA AGTCGACTGCTATGCTCAAAAAGTAAAAAAAGCTCAACAGTTAAAATCTAATGTTTGTTTTCTTTCCTGTTATATTATAAGGATATGCAC GTTTGTTCTGGAAAAGATAGAATTTGTCTCTAAAAGACTTGAAATTGTAATTAAAATGGCAAGCTAATCAAACATAAGCTTCATTAAGTG GGATTCTAAGACAGTCTGTGTTTTTATATTTCAAGGGTTTAACCCTTTGAGCCTTACATCTCATTCACTGTCTTTCTCCAAGAAAAGTAT TTTGGGCGGACAGTCAGATCAAGCAGTAAAATTAGCTCTTTCAAATCTTCTTGTCATGTAAAATGAAGCTAGTCTGTTTTAAAATTTTTA GTTTTGGATTGTATACTAATGAAAATCTTAATGATGTTTTTGATTTTTATATACTTATTTTAAAGAAAATCTTATATAGTACATTTTACA AAAATTATAAAAAATGAATTAGTACTGGCGAGGACTAAATGAAACAATAATTTTTCATTTTGATAACTAGCTTTCCAGGTGGACTTAGCC ATAGGAAAATATTACTAATGTAATTTAACAAATTGCTGCATGTATTCCATTTAAAAATATGTTTAAATTGTCCTAAAACAAAATAATTTT CTCCCTAGGAGTATGCATTTGGCTACAGTGTTTTGAAACAGAAACCTTAGAATAGGTCATTGGTATGGGCTGAACTGTGTATCCCCCAAT TCATTTGTTGAGGTCCTAACTCCCATTTCTTTTGAATGTGACTGTTCGGAGATGAGGCCTTTAAAGAGGTGACTTAAGTTCAAAGGAGGC TGTTAGTCTAATCCAACATGGTGTCCTTTGGACATAAGAGATACCAGCAATGTGTGCACAGAACAAAGACCAGGAGAGGACACAGTGAGA AGGCAGTTATCTGCAAGCAAAGAGAGAGGCTTCAGAAGAAACAAAATCACCAGCACCTTGATCTTTGACTTCTAATCTCCAGAATAGTGA GAAATAAATTTCTGTTGTTAAGCCGTCCACTGTGGGAGGCCGACGCAGGAGGATTGCTTGAGGCCAGGAGTTCAAGGCCAGCCTGGACAA CATAGTAAGACCCTATCTCTACCCCCCTAATAAATTAATTTAAAAAGCCCCCCAATCTGTGGTATTTTATTATGGCAGCCCTAGCAAGCT AATACAGTGGTTTGAGAGGCTGGGAGGGTTGAGGGGAAGATAAACTTTTAAAAAGCTCTTATCTTTCATTTCAATCAGTTAAAAATACTT GCTCAGTGTAACAATTTTGCTTCTCAGCTTCCACTCTAATATTGTTGTGCCATTAAGCAATTTAGCTAATCCTGACATTTCTTAGATTCA TAATGTTAGGAGCATTTAATCTGTATTTTACAAGTTAGGAAGCAGAGGATCAGAGATGGGAAAGGACTAGCCCAAGGCCAACATTAACAA GCCCTCTAACAAAAACTTTACAATACATTTATGTTGAATGGAACTCCAAGATCTCACCTCTCCATCCAGGAATGGAGTCCATGTAATCAA AGTGAACTTAAAAATAGGACAGTTTCAACAAGTCAGGAGATTCACAGCAACTGATCAAAGGGAGTCCAGTCAACGTGAGCAAGCGTGATT ATGATGAGGAAGCCCCCTCTGCTTTAATCCACACAAGGAACGTAACCTGAAGTAACCTGATGTTAACCAATCTGCTGTGTCTACTATGCT GTTTCCTTGTTCCTGCTAGTGCTGCTTTACAAATGCAGACCATTCTATCATACCTGGCGGGGCTTCTGTTTTATTTTGTAGGCTGGATGC >2217_2217_2_ADCY2-HSDL2_ADCY2_chr5_7773214_ENST00000537121_HSDL2_chr9_115179121_ENST00000398805_length(amino acids)=901AA_BP=614 MDLRWARDLHLREASRSVAFTTLRLGAVTTGLLTFREPGDKEKSGKGLGKRWRIQREESQERLLLSLLPAHIAMEMKAEIIQRLQGPKAG QMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRD PYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL RTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGI SFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFS ASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERSKACIPYLKKSKVAH ILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVLGMAEEFKGEIAVNALWPKTAIHTAAMDMLGGPGIESQCRKVDIIADAAYSIFQKPKS FTGNFVIDENILKEEGIENFDVYAIKPGHPLQPDFFLDEYPEAVSKKVESTGAVPEFKEEKLQLQPKPRSGAVEETFRIVKDSLSDDVVK ATQAIYLFELSGEDGGTWFLDLKSKGGNVGYGEPSDQADVVMSMTTDDFVKMFSGKLKPTMAFMSGKLKIKGNMALAIKLEKLMNQMNAR -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for ADCY2-HSDL2 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 905_922 | 794.6666666666666 | 1092.0 | GNAS |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 990_993 | 794.6666666666666 | 1092.0 | GNAS |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for ADCY2-HSDL2 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for ADCY2-HSDL2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ADCY2 | C0005586 | Bipolar Disorder | 2 | CTD_human;PSYGENET |
Hgene | ADCY2 | C0004096 | Asthma | 1 | CTD_human |
Hgene | ADCY2 | C0005587 | Depression, Bipolar | 1 | CTD_human |
Hgene | ADCY2 | C0024713 | Manic Disorder | 1 | CTD_human |
Hgene | ADCY2 | C0338831 | Manic | 1 | CTD_human |
Tgene | C0023903 | Liver neoplasms | 1 | CTD_human | |
Tgene | C0345904 | Malignant neoplasm of liver | 1 | CTD_human |