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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATF7-KRT83 (FusionGDB2 ID:HG11016TG3889)

Fusion Gene Summary for ATF7-KRT83

check button Fusion gene summary
Fusion gene informationFusion gene name: ATF7-KRT83
Fusion gene ID: hg11016tg3889
HgeneTgene
Gene symbol

ATF7

KRT83

Gene ID

11016

3889

Gene nameactivating transcription factor 7keratin 83
SynonymsATFAEKVP5|HB3|Hb-3|KRTHB3|MNLIX
Cytomap('ATF7')('KRT83')

12q13.13

12q13.13

Type of geneprotein-codingprotein-coding
Descriptioncyclic AMP-dependent transcription factor ATF-7transcription factor ATF-Akeratin, type II cuticular Hb3K83hHb3hair keratin K2.10hard keratin, type II, 3keratin 83, type IIkeratin, hair, basic, 3type II hair keratin Hb3type-II keratin Kb23
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000546661, ENST00000328463, 
ENST00000415113, ENST00000420353, 
ENST00000456903, ENST00000548446, 
ENST00000548118, ENST00000591397, 
Fusion gene scores* DoF score12 X 11 X 10=13202 X 2 X 2=8
# samples 182
** MAII scorelog2(18/1320*10)=-2.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: ATF7 [Title/Abstract] AND KRT83 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATF7(53917060)-KRT83(52715094), # samples:1
Anticipated loss of major functional domain due to fusion event.ATF7-KRT83 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATF7-KRT83 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATF7-KRT83 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATF7-KRT83 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATF7-KRT83 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ATF7-KRT83 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATF7

GO:0006355

regulation of transcription, DNA-templated

8288576

TgeneKRT83

GO:0007568

aging

21916889

TgeneKRT83

GO:0042633

hair cycle

21916889


check buttonFusion gene breakpoints across ATF7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across KRT83 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CN-6024ATF7chr12

53917060

-KRT83chr12

52715094

-


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Fusion Gene ORF analysis for ATF7-KRT83

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000546661ENST00000293670ATF7chr12

53917060

-KRT83chr12

52715094

-
Frame-shiftENST00000328463ENST00000293670ATF7chr12

53917060

-KRT83chr12

52715094

-
Frame-shiftENST00000415113ENST00000293670ATF7chr12

53917060

-KRT83chr12

52715094

-
Frame-shiftENST00000420353ENST00000293670ATF7chr12

53917060

-KRT83chr12

52715094

-
Frame-shiftENST00000456903ENST00000293670ATF7chr12

53917060

-KRT83chr12

52715094

-
In-frameENST00000548446ENST00000293670ATF7chr12

53917060

-KRT83chr12

52715094

-
intron-3CDSENST00000548118ENST00000293670ATF7chr12

53917060

-KRT83chr12

52715094

-
intron-3CDSENST00000591397ENST00000293670ATF7chr12

53917060

-KRT83chr12

52715094

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000548446ATF7chr1253917060-ENST00000293670KRT83chr1252715094-316713801131567484

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000548446ENST00000293670ATF7chr1253917060-KRT83chr1252715094-0.0735405760.9264594

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Fusion Genomic Features for ATF7-KRT83


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ATF7-KRT83


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:53917060/chr12:52715094)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF7chr12:53917060chr12:52715094ENST00000328463-1011332_395422495.0DomainbZIP
HgeneATF7chr12:53917060chr12:52715094ENST00000420353-1112332_395411484.0DomainbZIP
HgeneATF7chr12:53917060chr12:52715094ENST00000456903-1112332_395411484.0DomainbZIP
HgeneATF7chr12:53917060chr12:52715094ENST00000548446-1113332_395422612.0DomainbZIP
HgeneATF7chr12:53917060chr12:52715094ENST00000328463-10111_285422495.0RegionNote=Transactivation domain
HgeneATF7chr12:53917060chr12:52715094ENST00000328463-1011334_354422495.0RegionBasic motif
HgeneATF7chr12:53917060chr12:52715094ENST00000328463-1011360_388422495.0RegionLeucine-zipper
HgeneATF7chr12:53917060chr12:52715094ENST00000415113-11121_285390463.0RegionNote=Transactivation domain
HgeneATF7chr12:53917060chr12:52715094ENST00000415113-1112334_354390463.0RegionBasic motif
HgeneATF7chr12:53917060chr12:52715094ENST00000415113-1112360_388390463.0RegionLeucine-zipper
HgeneATF7chr12:53917060chr12:52715094ENST00000420353-11121_285411484.0RegionNote=Transactivation domain
HgeneATF7chr12:53917060chr12:52715094ENST00000420353-1112334_354411484.0RegionBasic motif
HgeneATF7chr12:53917060chr12:52715094ENST00000420353-1112360_388411484.0RegionLeucine-zipper
HgeneATF7chr12:53917060chr12:52715094ENST00000456903-11121_285411484.0RegionNote=Transactivation domain
HgeneATF7chr12:53917060chr12:52715094ENST00000456903-1112334_354411484.0RegionBasic motif
HgeneATF7chr12:53917060chr12:52715094ENST00000456903-1112360_388411484.0RegionLeucine-zipper
HgeneATF7chr12:53917060chr12:52715094ENST00000548446-11131_285422612.0RegionNote=Transactivation domain
HgeneATF7chr12:53917060chr12:52715094ENST00000548446-1113334_354422612.0RegionBasic motif
HgeneATF7chr12:53917060chr12:52715094ENST00000548446-1113360_388422612.0RegionLeucine-zipper
HgeneATF7chr12:53917060chr12:52715094ENST00000328463-10117_31422495.0Zinc fingerC2H2-type
HgeneATF7chr12:53917060chr12:52715094ENST00000415113-11127_31390463.0Zinc fingerC2H2-type
HgeneATF7chr12:53917060chr12:52715094ENST00000420353-11127_31411484.0Zinc fingerC2H2-type
HgeneATF7chr12:53917060chr12:52715094ENST00000456903-11127_31411484.0Zinc fingerC2H2-type
HgeneATF7chr12:53917060chr12:52715094ENST00000548446-11137_31422612.0Zinc fingerC2H2-type
TgeneKRT83chr12:53917060chr12:52715094ENST0000029367009111_4220494.0DomainIF rod
TgeneKRT83chr12:53917060chr12:52715094ENST0000029367009112_1460494.0RegionNote=Coil 1A
TgeneKRT83chr12:53917060chr12:52715094ENST0000029367009147_1560494.0RegionNote=Linker 1
TgeneKRT83chr12:53917060chr12:52715094ENST0000029367009157_2570494.0RegionNote=Coil 1B
TgeneKRT83chr12:53917060chr12:52715094ENST00000293670091_1110494.0RegionNote=Head
TgeneKRT83chr12:53917060chr12:52715094ENST0000029367009258_2740494.0RegionNote=Linker 12
TgeneKRT83chr12:53917060chr12:52715094ENST0000029367009275_4180494.0RegionNote=Coil 2
TgeneKRT83chr12:53917060chr12:52715094ENST0000029367009419_4930494.0RegionNote=Tail

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF7chr12:53917060chr12:52715094ENST00000415113-1112332_395390463.0DomainbZIP
HgeneATF7chr12:53917060chr12:52715094ENST00000548118-14332_3950118.0DomainbZIP
HgeneATF7chr12:53917060chr12:52715094ENST00000591397-14332_3950118.0DomainbZIP
HgeneATF7chr12:53917060chr12:52715094ENST00000328463-1011325_483422495.0RegionNote=Essential for binding adenovirus 2 E1A
HgeneATF7chr12:53917060chr12:52715094ENST00000415113-1112325_483390463.0RegionNote=Essential for binding adenovirus 2 E1A
HgeneATF7chr12:53917060chr12:52715094ENST00000420353-1112325_483411484.0RegionNote=Essential for binding adenovirus 2 E1A
HgeneATF7chr12:53917060chr12:52715094ENST00000456903-1112325_483411484.0RegionNote=Essential for binding adenovirus 2 E1A
HgeneATF7chr12:53917060chr12:52715094ENST00000548118-141_2850118.0RegionNote=Transactivation domain
HgeneATF7chr12:53917060chr12:52715094ENST00000548118-14325_4830118.0RegionNote=Essential for binding adenovirus 2 E1A
HgeneATF7chr12:53917060chr12:52715094ENST00000548118-14334_3540118.0RegionBasic motif
HgeneATF7chr12:53917060chr12:52715094ENST00000548118-14360_3880118.0RegionLeucine-zipper
HgeneATF7chr12:53917060chr12:52715094ENST00000548446-1113325_483422612.0RegionNote=Essential for binding adenovirus 2 E1A
HgeneATF7chr12:53917060chr12:52715094ENST00000591397-141_2850118.0RegionNote=Transactivation domain
HgeneATF7chr12:53917060chr12:52715094ENST00000591397-14325_4830118.0RegionNote=Essential for binding adenovirus 2 E1A
HgeneATF7chr12:53917060chr12:52715094ENST00000591397-14334_3540118.0RegionBasic motif
HgeneATF7chr12:53917060chr12:52715094ENST00000591397-14360_3880118.0RegionLeucine-zipper
HgeneATF7chr12:53917060chr12:52715094ENST00000548118-147_310118.0Zinc fingerC2H2-type
HgeneATF7chr12:53917060chr12:52715094ENST00000591397-147_310118.0Zinc fingerC2H2-type


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Fusion Gene Sequence for ATF7-KRT83


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7495_7495_1_ATF7-KRT83_ATF7_chr12_53917060_ENST00000548446_KRT83_chr12_52715094_ENST00000293670_length(transcript)=3167nt_BP=1380nt
AGTATCCGTTCCGCCAAGGGGGGAAAGGAGGAGCTGGAGACAGATTGTAGGACCGAGCGCGGGCAGGCGGGAGGCAACGGAGCTACCAGC
CGCTCCTCTCTGCTATATGAAATATGGGAGACGACAGACCGTTTGTGTGCAATGCCCCGGGCTGTGGACAGAGATTTACAAACGAGGACC
ACCTGGCAGTTCATAAACACAAGCATGAGATGACATTGAAATTTGGCCCAGCCCGAACTGACTCAGTCATCATTGCAGATCAAACGCCTA
CTCCAACTAGATTCCTGAAGAACTGTGAGGAGGTGGGACTCTTCAATGAACTAGCTAGCTCCTTTGAACATGAATTCAAGAAAGCTGCAG
ATGAGGATGAGAAAAAGGCAAGAAGCAGGACTGTTGCCAAAAAACTGGTGGCTGCTGCTGGGCCCCTTGACATGTCTCTGCCTTCCACAC
CAGACATCAAAATCAAAGAAGAAGAGCCAGTGGAGGTAGACTCATCCCCACCTGATAGCCCTGCCTCTAGTCCCTGTTCCCCACCACTGA
AGGAGAAGGAGGTTACCCCAAAGCCTGTTCTGATCTCTACCCCCACACCCACCATTGTACGTCCTGGCTCCCTGCCTCTCCACTTGGGCT
ATGATCCACTTCATCCAACCCTTCCCTCCCCAACCTCTGTCATCACACAGGCTCCACCATCCAACAGGCAAATGGGGTCTCCCACTGGCT
CCCTCCCTCTTGTCATGCATCTTGCTAATGGACAGACCATGCCTGTGTTGCCAGGGCCTCCAGTACAGATGCCGTCTGTTATATCGCTGG
CCAGACCTGTGTCCATGGTGCCCAACATTCCTGGTATCCCTGGCCCACCAGTTAACAGTAGTGGCTCCATTTCTCCCTCTGGCCACCCTA
TACCATCAGAAGCCAAGATGAGACTGAAAGCCACCCTAACTCACCAAGTCTCCTCAATCAATGGTGGTTGTGGAATGGTGGTGGGTACTG
CCAGCACCATGGTGACAGCCCGCCCAGAGCAGAGCCAGATTCTCATCCAGCACCCTGATGCCCCATCCCCTGCCCAGCCACAGGTCTCAC
CAGCTCAGCCCACCCCTAGTACTGGGGGGCGACGGCGGCGCACAGTAGATGAAGATCCAGATGAGCGACGGCAGCGCTTTCTGGAGCGCA
ACCGGGCTGCAGCCTCCCGCTGCCGCCAAAAGCGAAAGCTGTGGGTGTCCTCCCTAGAGAAGAAGGCCGAAGAACTCACTTCTCAGAACA
TTCAGCTGAGTAATGAAGTCACATTACTACGCAATGAGGTGGCCCAGTTGAAACAGCTACTGTTAGCTCATAAAGACTGCCCAGTCACTG
CACTACAGAAAAAGACTCAAGGCTATTTAGGTGTCAGCAGCTCCCGGGGTGGGGTTGTGTGCGGGGATCTCTGCGTGTCGGGCTCCCGGC
CGGTGACGGGCAGCGTCTGCAGTGCCCCCTGCAACGGGAACCTGGTGGTGAGCACTGGTTTGTGCAAGCCCTGTGGCCAGCTGAACACCA
CCTGTGGAGGGGGCTCCTGCGGCCAGGGGAGGCATTAAGTGGCCCAAAAGAGAGCCAGGGGAGCCCCTTCTGCCTGCCAGACGTGCCACT
GCCCCACCACCAGCTGAAAACAGCAGCACATCGCTGGCTTTTCCCCTTGTGTTCTGAGAATACACCATCGGCTCATTCCCACCAGCGGCT
CCTCCCCACCTTTCATCCCACTGGAAAGGGGCCTGTGGCTGGGGAATAGACCCATTCCTTCCCCTGTCTCAGCCTTCAGCCCCTCCCGGG
GAGAAGGGCCTTGCTTCCCTGGAAGAAGCACTGTGAGACTGTTCCCCCTGCCTCTCTGGCCTCTTGTCTCCCCTTTTCCAATAAACTTGG
GGACCTGCGCTGTGTGAAGGTGTTGAAGCTGTGAATGTCTAACTCCAAGCTGGAAGCTGCGGTGGCCCAGTCTGAGCAGCAGGGTGAGGC
GGCCCTCAGTGATGCCCGCTGCAAGCTGGCCGAGCTGGAGGGCGCCCTGCAGAAGGCCAAGCAAGACATGGCCTGCCTGATCAGGGAGTA
CCAGGAGGTGATGAACTCCAAGCTAGGCCTGGATATCGAGATCGCCACCTACAGGCGCCTGCTGGAGGGCGAGGAGCAGAGTGTGAGGAG
ATGAAGGCCACAGTGATCAGGCACGGGGAGACCCTGCGCCGCACCAAGGAGGAGATCAACGAGCTGAACCGCATGATCCAGAGGCTGACA
GCCGAGGTGGAGAATGCCAAGTGCCAGGAGATCCGCATTCTCCAATCCCACATCTCAGACACCTCCGTGGTTGTCAAGCTGGACAACAGC
CGGGACCTGAACATGGACTGCATCGTTGCCGAGATCAAGGCACAGTATGATGACATTGCCACCCGTAGCCGGGCTGAGGCCGAGTCCTGG
TATCGCAGCAAGGATGTGGACTGCGCCTACCTCCGCAAGTCAGACCTGGAGGCCAACGTGGAGGCCCTGATCCAGGAGATTGACTTCCTG
AGGCGGCTGTACGAGGAGGTATGAAGAAGAAGTAGCACTTCGAGCCACAGCAGAGAACGAGTTTGTGGCTCTAAAGAAGGTGCGCTTCCT
GGAGCAGCAGAACAAGCTGCTGGAGACAAAGCTGCAGTTCTACCAAAACCGCGAGTGCTGCCAGAGTAACCTGGAGCCCCTGTTTGCTGG
CTACATCGAGACTCTGCGGCGGGAGGCCGAGTGCGTGGAGGCTGACAGTGGGAGGCTGGCCTCAGAGCTCAACCACGTGCAGGAGGTGCT
GGAGGGCTACAAGAAGAAGCTGTGGGTTCCGCCCTGGAAACTTCAGCTGTGTCTCTGCCTGCGGGCCCCGGCCAAGCCGCTGCTGCATCA
CCGCCGCCCCCTACCGCGGCATCTCCTGCTACCGCGGCCTCACCGGGGGCTTTGGCAGCCACAGCGTGTGCGGGGGCTTCCGCGCCGGCT
CCTGCGGACGCAGCTTCGGCTACCGCTCCGGGGGCGTGTGCGGACCCAGCCCCCCATGCATCACCACCGTGTCGGTCAACGAGAGCCTCC
TCACGCCCCTCAACCTGGAGATAGACCCCAACGCGCAGTGCGTGAAGCAGGAGGAGAAGGAGCAGATCAAGTCCCTCAACAGCAGATTCG

>7495_7495_1_ATF7-KRT83_ATF7_chr12_53917060_ENST00000548446_KRT83_chr12_52715094_ENST00000293670_length(amino acids)=484AA_BP=0
MGDDRPFVCNAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARTDSVIIADQTPTPTRFLKNCEEVGLFNELASSFEHEFKKAADEDEKKAR
SRTVAKKLVAAAGPLDMSLPSTPDIKIKEEEPVEVDSSPPDSPASSPCSPPLKEKEVTPKPVLISTPTPTIVRPGSLPLHLGYDPLHPTL
PSPTSVITQAPPSNRQMGSPTGSLPLVMHLANGQTMPVLPGPPVQMPSVISLARPVSMVPNIPGIPGPPVNSSGSISPSGHPIPSEAKMR
LKATLTHQVSSINGGCGMVVGTASTMVTARPEQSQILIQHPDAPSPAQPQVSPAQPTPSTGGRRRRTVDEDPDERRQRFLERNRAAASRC
RQKRKLWVSSLEKKAEELTSQNIQLSNEVTLLRNEVAQLKQLLLAHKDCPVTALQKKTQGYLGVSSSRGGVVCGDLCVSGSRPVTGSVCS

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Fusion Gene PPI Analysis for ATF7-KRT83


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATF7-KRT83


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATF7-KRT83


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0546966Monilethrix2CTD_human;ORPHANET;UNIPROT
TgeneC0265961Erythrokeratodermia variabilis1ORPHANET