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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADAP1-METTL2B (FusionGDB2 ID:HG11033TG55798)

Fusion Gene Summary for ADAP1-METTL2B

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAP1-METTL2B
Fusion gene ID: hg11033tg55798
HgeneTgene
Gene symbol

ADAP1

METTL2B

Gene ID

11033

55798

Gene nameArfGAP with dual PH domains 1methyltransferase like 2B
SynonymsCENTA1|GCS1L|p42IP4METL|METTL2|METTL2A|PSENIP1
Cytomap('ADAP1')('METTL2B')

7p22.3

7q32.1

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with dual PH domain-containing protein 1centaurin-alphacentaurin-alpha-1cnt-a1putative MAPK-activating protein PM25tRNA N(3)-methylcytidine methyltransferase METTL2Bmethyltransferase-like protein 2B
Modification date2020031320200313
UniProtAcc.

Q6P1Q9

Ensembl transtripts involved in fusion geneENST00000265846, ENST00000449296, 
ENST00000463358, ENST00000539900, 
Fusion gene scores* DoF score13 X 10 X 8=10405 X 8 X 4=160
# samples 188
** MAII scorelog2(18/1040*10)=-2.53051471669878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/160*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAP1 [Title/Abstract] AND METTL2B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADAP1(994032)-METTL2B(128141816), # samples:1
Anticipated loss of major functional domain due to fusion event.ADAP1-METTL2B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAP1-METTL2B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ADAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across METTL2B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-XR-A8TD-01AADAP1chr7

994032

-METTL2Bchr7

128141816

+


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Fusion Gene ORF analysis for ADAP1-METTL2B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265846ENST00000473488ADAP1chr7

994032

-METTL2Bchr7

128141816

+
In-frameENST00000265846ENST00000262432ADAP1chr7

994032

-METTL2Bchr7

128141816

+
In-frameENST00000265846ENST00000480046ADAP1chr7

994032

-METTL2Bchr7

128141816

+
intron-3CDSENST00000449296ENST00000262432ADAP1chr7

994032

-METTL2Bchr7

128141816

+
intron-3CDSENST00000449296ENST00000480046ADAP1chr7

994032

-METTL2Bchr7

128141816

+
intron-3CDSENST00000463358ENST00000262432ADAP1chr7

994032

-METTL2Bchr7

128141816

+
intron-3CDSENST00000463358ENST00000480046ADAP1chr7

994032

-METTL2Bchr7

128141816

+
intron-3CDSENST00000539900ENST00000262432ADAP1chr7

994032

-METTL2Bchr7

128141816

+
intron-3CDSENST00000539900ENST00000480046ADAP1chr7

994032

-METTL2Bchr7

128141816

+
intron-intronENST00000449296ENST00000473488ADAP1chr7

994032

-METTL2Bchr7

128141816

+
intron-intronENST00000463358ENST00000473488ADAP1chr7

994032

-METTL2Bchr7

128141816

+
intron-intronENST00000539900ENST00000473488ADAP1chr7

994032

-METTL2Bchr7

128141816

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000265846ADAP1chr7994032-ENST00000262432METTL2Bchr7128141816+14653026901230
ENST00000265846ADAP1chr7994032-ENST00000480046METTL2Bchr7128141816+51433026901230

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265846ENST00000262432ADAP1chr7994032-METTL2Bchr7128141816+0.28922070.7107793
ENST00000265846ENST00000480046ADAP1chr7994032-METTL2Bchr7128141816+0.349011120.65098894

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Fusion Genomic Features for ADAP1-METTL2B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ADAP1chr7994031-METTL2Bchr7128141815+4.59E-121
ADAP1chr7994031-METTL2Bchr7128141815+4.59E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ADAP1-METTL2B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:994032/chr7:128141816)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.METTL2B

Q6P1Q9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). {ECO:0000269|PubMed:28655767}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAP1chr7:994032chr7:128141816ENST00000265846-111129_23027375.0DomainPH 1
HgeneADAP1chr7:994032chr7:128141816ENST00000265846-111252_35627375.0DomainPH 2
HgeneADAP1chr7:994032chr7:128141816ENST00000265846-1117_12627375.0DomainArf-GAP
HgeneADAP1chr7:994032chr7:128141816ENST00000265846-11121_4427375.0Zinc fingerC4-type


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Fusion Gene Sequence for ADAP1-METTL2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2153_2153_1_ADAP1-METTL2B_ADAP1_chr7_994032_ENST00000265846_METTL2B_chr7_128141816_ENST00000262432_length(transcript)=1465nt_BP=302nt
CCGGGCCCCGCGCCGGCACTCGCTCAGCGACCGCGGCGGAGACACGAGCGGCGGCGGCGGAGCCCAGAGGGCGGCGGGAATGCGGAACCG
GCGCGCGGGCTGAGGCCGCCCGGGATGGCGCAGGGGCGGCGGCGGCGGGCGGCCTGCGCGGGGCCCTAGCGAGCCGGGCTGACGCTCCCG
GCCCCGGCCCCGGCATCGGCATCGCGGGCGCATCGCGGCCATGGCCAAGGAGCGGCGCAGGGCGGTCCTGGAGCTGCTGCAGCGGCCGGG
GAACGCGCGCTGCGCGGACTGCGGCGCCCCGGAGGAACTGGACACGCTTTTCACCACTGCTGGACTGGAAAAAGTTCAGAATCTGGTGGA
CCGCCGACTGCAGGTGAACCGAGGGAAGCAACTGACAATGTACCGGGTTTGGATTCAGTGCAAATACTGCAAGCCCCTTCTGTCCAGCAC
CAGCTAAGAGGCACCTGCTGCCAACACGATGCAAGCCCGTTGTGTTTCCGAGCTTTTTTAAAAAAAAATTTGTAGCACCGGGCATGGTGC
ATGCCTGTAATCCCAGCCACTCAGGAGGCTGAGGCAGGGAGGATCCATTGAGCCCAGGAGTCCAGCCTGGGCAAAATAGCGAGAGACCCT
GAATCTGAAAGTAATGATAAAATAAAAAGAATATAAATGAGGTCTCGTTGATGCTGGACAATTCAAGAATTCAGACTTGAACCTTAAACC
TAGGAAAAGTTACTTTGTATCAGGATTCTAACAATTATGCTTCATATTTGTGAAGTCCTTTAAAACATAATTTTCTCAAGTTCTTTCTTT
GAGACCTCAATCTGTCTTAGCATTTTGTAACTAATAACTGAAATTTTATTCAAAGGAATTGTAAACCTTAAACCACCATTTATTTCCATG
TGAAAAAGTGTTATATATGACAAGTGTTTTTTGATTGTAATTGCGTTAAATCTTTTGAGAGTGTAAATGCCGGGCTAGGCAATTGCAGTT
AATACATACAGGGGTTAGTGAAGGGCTTATTAAGTTGTAGGGGAAGCAAGCTGGGAAGAATCAGATCAGATATTTTCCTGACAAGAAAAA
AATGACCCTGTAGACAGCATCAAAATGTGGTGTTCTTGTTAAGTAATTGATCGTGGTCTTTGCTTTAATCTTAGTTCCGCCAGGCACGGT
GGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACCTGAGGTCAGGAGTTCGAGACCAGCGTGGCCAACATGGT
GAAACCCCGTCTCTACTAAAGATAAAAAAATTAGCTGGGTGTGTTGGTGGGTGCCTGTAATCCAGCTACTCGGGAGGCTGAGGCAGGAGA
ATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCGCCACTGTACTCCAGCCTGGGCAACAAAGCAAGACTCTGTCTCAA

>2153_2153_1_ADAP1-METTL2B_ADAP1_chr7_994032_ENST00000265846_METTL2B_chr7_128141816_ENST00000262432_length(amino acids)=230AA_BP=1
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF
ALNPNPVHCQLLPSVHLQSAVHQILNFFQSSSGEKRVQFLRGAAVRAARVPRPLQQLQDRPAPLLGHGRDAPAMPMPGPGPGASARLARA

--------------------------------------------------------------
>2153_2153_2_ADAP1-METTL2B_ADAP1_chr7_994032_ENST00000265846_METTL2B_chr7_128141816_ENST00000480046_length(transcript)=5143nt_BP=302nt
CCGGGCCCCGCGCCGGCACTCGCTCAGCGACCGCGGCGGAGACACGAGCGGCGGCGGCGGAGCCCAGAGGGCGGCGGGAATGCGGAACCG
GCGCGCGGGCTGAGGCCGCCCGGGATGGCGCAGGGGCGGCGGCGGCGGGCGGCCTGCGCGGGGCCCTAGCGAGCCGGGCTGACGCTCCCG
GCCCCGGCCCCGGCATCGGCATCGCGGGCGCATCGCGGCCATGGCCAAGGAGCGGCGCAGGGCGGTCCTGGAGCTGCTGCAGCGGCCGGG
GAACGCGCGCTGCGCGGACTGCGGCGCCCCGGAGGAACTGGACACGCTTTTCACCACTGCTGGACTGGAAAAAGTTCAGAATCTGGTGGA
CCGCCGACTGCAGGTGAACCGAGGGAAGCAACTGACAATGTACCGGGTTTGGATTCAGTGCAAATACTGCAAGCCCCTTCTGTCCAGCAC
CAGCTAAGAGGCACCTGCTGCCAACACGATGCAAGCCCGTTGTGTTTCCGAGCTTTTTTAAAAAAAAATTTGTAGCACCGGGCATGGTGC
ATGCCTGTAATCCCAGCCACTCAGGAGGCTGAGGCAGGGAGGATCCATTGAGCCCAGGAGTCCAGCCTGGGCAAAATAGCGAGAGACCCT
GAATCTGAAAGTAATGATAAAATAAAAAGAATATAAATGAGGTCTCGTTGATGCTGGACAATTCAAGAATTCAGACTTGAACCTTAAACC
TAGGAAAAGTTACTTTGTATCAGGATTCTAACAATTATGCTTCATATTTGTGAAGTCCTTTAAAACATAATTTTCTCAAGTTCTTTCTTT
GAGACCTCAATCTGTCTTAGCATTTTGTAACTAATAACTGAAATTTTATTCAAAGGAATTGTAAACCTTAAACCACCATTTATTTCCATG
TGAAAAAGTGTTATATATGACAAGTGTTTTTTGATTGTAATTGCGTTAAATCTTTTGAGAGTGTAAATGCCGGGCTAGGCAATTGCAGTT
AATACATACAGGGGTTAGTGAAGGGCTTATTAAGTTGTAGGGGAAGCAAGCTGGGAAGAATCAGATCAGATATTTTCCTGACAAGAAAAA
AATGACCCTGTAGACAGCATCAAAATGTGGTGTTCTTGTTAAGTAATTGATCGTGGTCTTTGCTTTAATCTTAGTTCCGCCAGGCACGGT
GGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACCTGAGGTCAGGAGTTCGAGACCAGCGTGGCCAACATGGT
GAAACCCCGTCTCTACTAAAGATAAAAAAATTAGCTGGGTGTGTTGGTGGGTGCCTGTAATCCAGCTACTCGGGAGGCTGAGGCAGGAGA
ATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCGCCACTGTACTCCAGCCTGGGCAACAAAGCAAGACTCTGTCTCAA
AAAAATAAAAATAAAAAAAATCTTAGTTCCATGGAATTTTAAGCACTGTTCCCCCTCTAACCTATGTCTAAAGAATTAAAAGAATTTGGC
TGGGTGCGGTAGCTCATGCCTGTAATCCCAACACTTTGGGAGGCTGAGGCAGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCT
AACACGGTGAAACCTCGTCTCCACTAAAAATACCAAAAAAAATAGCTGGGCATGGTGGCATGCGCCTGTAGTCCCCTGTAGTCCCAGCTA
CTCGGGAGGCTAAGGCAGGAGAATCGTTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATCATGTCACTGCATTCCAGCCTGGGCA
ACAGAGGAAGACTCTGTCTCAAAAAAATAAAAGAAAAGAATTTTCACTTTTTGCAAAATTATCTTTTTTTACTGCACCCTTAAGTGTTTG
ACACAAAAGGAATTGAGAGAACTTCTTAATTTTAACCACATCATCACTTCACTTCTGAATGTGATCACTGTCAGTGTTAGATGCTTTTTT
TTTTTTTTTTTAGGAGACAGGGCTCTCACTTTGTTGCCCAGGCTGGAGTTCAGTGGTGCAATGATAGCTCATTATCACCTCGAACTTCTG
GCTTGAGCCATCGCTCCACCTCAGCCTCCTGAGTAGCTAGGACTGCAGGTGGGCACCATCATGCCTAGCTAATTGTTAGATCCTTTTTTT
TTATGTTCTGCATTTTTTCAATTATTTTTACATATTTCTGTCTTGATCCATGCAGTTATAGGATATATCCTTAATTTTAGAAAGTAAGGA
CTTTTCGACCAGGCATGGCGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCACTTGAGGTCAGGAGTTCCAGT
CCAGCCCGGCTAACATAGTGAAACCCCGTCTCCACTAAAAAATAAAAAATCAGCCCGGCATGGTTGTGGGCGCCTGTAATCCCAGCTACT
CAGGAGGCTGAGGTAGGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATGGTGCCATTGCACTCCAGCCTGGGCGAC
AAGAGCGAAACTGCATCTCAAAAACAAAGATGCCTAGCTTTCACCTTGTTGATGTTTTTCTAAATTTTGGAATAATAAATTTATATAGGA
ATACTGCAAGAATAGTCCATTTTTTTCTGATGTCCCAACATCAGCAAATATATTACCAAATATATCCATCACAAGTAGGAATACATGGAA
ACATTAATGCCAGCCACTAACCATTCATGTTTACCCAGTAGTCCCAATAATAGCTTTGTCACACAAAAACATGATTATGTTGGCTGGGCA
CAGTGGCTCCTGTAATCTTAGCATTTTGGGAGCCCAAGGCAGGAGGATGACTTGAGGCCAGGAGTTCAAGACCAGGCTGGGTAATGTAGC
AAGACCCTGACTTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTACAATGGCACGATCTCGGCTCACT
GCAATCTCCACCTCCCAAGTTTAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGAATTACAGGCATGCAGCACCATTCCCAGCTAA
ATTTTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCAGGCTGATCTCGAACTCCCGACCTCAGGTGATCTGCCCGCCTCAGC
CTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCGGCCAAGACCCTGACTTTTTAAAAAATGTTAAACATAGGCCGGGTGCAG
TGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCATTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACTTAA
TGAAACCCCATCTCTGCTAACAATACAGACCAGGCATGGTGGCTCACACCTGTAATCCCAGCACTTTGAGAGACCGAGGCAGGTGGATCA
CCTGAGGTCGGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATAGCCAGGTGTGATGGCGCAT
GCCTGTAACCCCATCTACTTGGAAGGCTGAGGCAGGAGAATCACTTGAATCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATGGCGCCATT
GCACTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCAAAAAAAAAAAAAAAAAAAAATTAGCTGGGCATGGTGGTGGGCGCCTGTAAT
CCCAGCTATCTGGGAGGCTGAGTCTAGAGAATCATTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGCACCATTGCACTCCAG
CCTGGGCAACAGTGAGACTCCGTCTCAAAATAAAAAAACAAAAAAAATGTAAAAAATAAATAATTGTATTGAATTTATTAGTTGTGTCTC
AGTCTCCTTCAGTCTACAGTTTAGGCTTGCTTTTGCACCTTTGCATTTTAAGGTAAGAGGCTATTGTGTAAACTCGAATTGGGTTTGTTG
GTGTTTCTTCATGATTTGGTTCAGGCTCTGCATTTTGGGCAGGAATATTCAGAGGTGATGCTGTGTTCCTCCCATAGGATCGTATCAGGC
GACACATGATTATGAATTTCCCCATTATTGGTGATGTCACTTAGTTGTGTTGTCTGCCAGGTTCTGCCACTGTAAAGTTAATAAGTATTT
TGTAGGGAAGTGCTTTGAGACTAAATATCCTGTTCCTCATCAAACTTCTACCCCCTAGTTTCAGTATCTATTGCTGTTTTTTGTCTGAAT
AACTATGATAGTTGCCAAATAGTGGTTTCTGATCCTTCCATTCCTTCTACACTGATTGGTTGGTATTTTGTACAGAAAAGCTTTCTCATA
TCTGATTTACTTGTCTCAATATGGACCCATGGGTATTTGAGTTTCTTGTGGGGTTATTTGTTGTTGTTTTTGAGACAGGCTCACCCAGGC
TGGAGTGCAGCAGCACGATCACTGCTTACTGCTTACTGCAGCCTCGACCTCCCATGCTCAAGTGATTCTCCCACCCCAGCCTCCCAAGTA
GATGGGACTACAGGCATGTGCCACCAAGCCTAATTTTTGTATTTTTTGTAGAGACAGGGTTTCACCATGTGTCCCAGGCTGGTCTTGAGC
TCCTGAGCTCAAGCAATCCTCCCACCTCGGCCTCCCAAAGTGCTGGGATGAGCCACCGTGACTGGCCCCACTTAATGGGTTTTCAGAGGT
GGGAGCAAAGAATGAAGGGAGGAAGAGAGCTCCCATCTTTTCCATTACCGTATTTACTTAAAACTGGAAAAAACTGAATCACTGGGATGG
TATTTCATTTATCTTTTGAAATGAAGAATAGATACATTAATTTAAATGATTCTCTAAAGACTGTCCTTCAGCATCCCTAAAGCATTGCAA
AACTATAGGCACAGTTTTTATTTTATCTTTCTGGCACCTGGTTTGGGCTTTGGCTTAGATTAAAAAGACGAGCCTTCTCCTGCCCCTGCT
CCCTTTTATTCCCTGCCATCTGCTAAGCTCGACTTTTTATCTCTCAGGCCAAATTTGACTCTGTAAGGGACTTTGCATAACGTTTCATCC
TCAGAATCGCTAATGATGGGCAGAGGACTGTTACATGTGTTGGGAGGGATTAAAGTATATGACCTCAGTGCCACTTAAAAAATAAATACT

>2153_2153_2_ADAP1-METTL2B_ADAP1_chr7_994032_ENST00000265846_METTL2B_chr7_128141816_ENST00000480046_length(amino acids)=230AA_BP=1
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF
ALNPNPVHCQLLPSVHLQSAVHQILNFFQSSSGEKRVQFLRGAAVRAARVPRPLQQLQDRPAPLLGHGRDAPAMPMPGPGPGASARLARA

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Fusion Gene PPI Analysis for ADAP1-METTL2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADAP1-METTL2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADAP1-METTL2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource