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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ABHD2-BIRC6 (FusionGDB2 ID:HG11057TG57448) |
Fusion Gene Summary for ABHD2-BIRC6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ABHD2-BIRC6 | Fusion gene ID: hg11057tg57448 | Hgene | Tgene | Gene symbol | ABHD2 | BIRC6 | Gene ID | 11057 | 57448 |
| Gene name | abhydrolase domain containing 2, acylglycerol lipase | baculoviral IAP repeat containing 6 | |
| Synonyms | HS1-2|LABH2|PHPS1-2 | APOLLON|BRUCE | |
| Cytomap | ('ABHD2')('BIRC6') 15q26.1 | 2p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | monoacylglycerol lipase ABHD22-arachidonoylglycerol hydrolaseabhydrolase domain containing 2abhydrolase domain-containing protein 2acetylesterasealpha/beta hydrolase domain containing protein 2lung alpha/beta hydrolase 2progesterone-sensitive lipas | baculoviral IAP repeat-containing protein 6BIR repeat-containing ubiquitin-conjugating enzymeRING-type E3 ubiquitin transferase BIRC6ubiquitin-conjugating BIR-domain enzyme apollon | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000352732, ENST00000355100, ENST00000562254, ENST00000565973, | ||
| Fusion gene scores | * DoF score | 10 X 10 X 5=500 | 23 X 19 X 14=6118 |
| # samples | 11 | 29 | |
| ** MAII score | log2(11/500*10)=-2.18442457113743 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(29/6118*10)=-4.39893530154327 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ABHD2 [Title/Abstract] AND BIRC6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ABHD2(89745591)-BIRC6(32820101), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ABHD2-BIRC6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABHD2-BIRC6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABHD2-BIRC6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ABHD2-BIRC6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ABHD2 | GO:0032570 | response to progesterone | 26989199 |
| Hgene | ABHD2 | GO:0043401 | steroid hormone mediated signaling pathway | 26989199 |
| Hgene | ABHD2 | GO:0046464 | acylglycerol catabolic process | 26989199 |
| Hgene | ABHD2 | GO:0048240 | sperm capacitation | 26989199 |
| Fusion gene breakpoints across ABHD2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across BIRC6 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BLCA | TCGA-GV-A3QI-01A | ABHD2 | chr15 | 89745591 | - | BIRC6 | chr2 | 32820101 | + |
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Fusion Gene ORF analysis for ABHD2-BIRC6 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000352732 | ENST00000421745 | ABHD2 | chr15 | 89745591 | - | BIRC6 | chr2 | 32820101 | + |
| In-frame | ENST00000355100 | ENST00000421745 | ABHD2 | chr15 | 89745591 | - | BIRC6 | chr2 | 32820101 | + |
| intron-3CDS | ENST00000562254 | ENST00000421745 | ABHD2 | chr15 | 89745591 | - | BIRC6 | chr2 | 32820101 | + |
| intron-3CDS | ENST00000565973 | ENST00000421745 | ABHD2 | chr15 | 89745591 | - | BIRC6 | chr2 | 32820101 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000352732 | ABHD2 | chr15 | 89745591 | - | ENST00000421745 | BIRC6 | chr2 | 32820101 | + | 10803 | 8735 | 511 | 1797 | 428 |
| ENST00000355100 | ABHD2 | chr15 | 89745591 | - | ENST00000421745 | BIRC6 | chr2 | 32820101 | + | 10756 | 8688 | 464 | 1750 | 428 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000352732 | ENST00000421745 | ABHD2 | chr15 | 89745591 | - | BIRC6 | chr2 | 32820101 | + | 0.00048575 | 0.9995142 |
| ENST00000355100 | ENST00000421745 | ABHD2 | chr15 | 89745591 | - | BIRC6 | chr2 | 32820101 | + | 0.000442655 | 0.9995573 |
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Fusion Genomic Features for ABHD2-BIRC6 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for ABHD2-BIRC6 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:89745591/chr2:32820101) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ABHD2 | chr15:89745591 | chr2:32820101 | ENST00000352732 | - | 11 | 11 | 128_382 | 2738 | 426.0 | Domain | AB hydrolase-1 |
| Hgene | ABHD2 | chr15:89745591 | chr2:32820101 | ENST00000355100 | - | 13 | 13 | 128_382 | 2738 | 426.0 | Domain | AB hydrolase-1 |
| Hgene | ABHD2 | chr15:89745591 | chr2:32820101 | ENST00000352732 | - | 11 | 11 | 1_9 | 2738 | 426.0 | Topological domain | Cytoplasmic |
| Hgene | ABHD2 | chr15:89745591 | chr2:32820101 | ENST00000352732 | - | 11 | 11 | 31_425 | 2738 | 426.0 | Topological domain | Extracellular |
| Hgene | ABHD2 | chr15:89745591 | chr2:32820101 | ENST00000355100 | - | 13 | 13 | 1_9 | 2738 | 426.0 | Topological domain | Cytoplasmic |
| Hgene | ABHD2 | chr15:89745591 | chr2:32820101 | ENST00000355100 | - | 13 | 13 | 31_425 | 2738 | 426.0 | Topological domain | Extracellular |
| Hgene | ABHD2 | chr15:89745591 | chr2:32820101 | ENST00000352732 | - | 11 | 11 | 10_30 | 2738 | 426.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Hgene | ABHD2 | chr15:89745591 | chr2:32820101 | ENST00000355100 | - | 13 | 13 | 10_30 | 2738 | 426.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | BIRC6 | chr15:89745591 | chr2:32820101 | ENST00000421745 | 66 | 74 | 4573_4740 | 4500 | 4858.0 | Domain | UBC core |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ABHD2 | chr15:89745591 | chr2:32820101 | ENST00000565973 | - | 1 | 15 | 128_382 | 0 | 426.0 | Domain | AB hydrolase-1 |
| Hgene | ABHD2 | chr15:89745591 | chr2:32820101 | ENST00000565973 | - | 1 | 15 | 1_9 | 0 | 426.0 | Topological domain | Cytoplasmic |
| Hgene | ABHD2 | chr15:89745591 | chr2:32820101 | ENST00000565973 | - | 1 | 15 | 31_425 | 0 | 426.0 | Topological domain | Extracellular |
| Hgene | ABHD2 | chr15:89745591 | chr2:32820101 | ENST00000565973 | - | 1 | 15 | 10_30 | 0 | 426.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | BIRC6 | chr15:89745591 | chr2:32820101 | ENST00000421745 | 66 | 74 | 1660_1668 | 4500 | 4858.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | BIRC6 | chr15:89745591 | chr2:32820101 | ENST00000421745 | 66 | 74 | 30_36 | 4500 | 4858.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | BIRC6 | chr15:89745591 | chr2:32820101 | ENST00000421745 | 66 | 74 | 284_358 | 4500 | 4858.0 | Repeat | Note=BIR |
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Fusion Gene Sequence for ABHD2-BIRC6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >419_419_1_ABHD2-BIRC6_ABHD2_chr15_89745591_ENST00000352732_BIRC6_chr2_32820101_ENST00000421745_length(transcript)=10803nt_BP=8735nt AGCCCTCCTCCCCTTTCCCCGCCCACTCCGGGCTGGCCTTATCCAGTAGCGTCTGGGTCCCTGGACTAAAGCCGTCAAATGTAACCAATT GCTGAGGAGCTCTCCCCTAAGAATCCCGCCTCCACTCTGAGGAACAGCTTCGCTGATCAATGGATCCCCTCCTAGACGCAATGAGCGCGC GGGGCAAGTGGAGAAGCGGCTGAACTGCCCAATGAACAAGCGGTTTCCGTGGTTAGGGGCGTGGCAGAAGCGGTCGTCAGGGGCGTGGCG GCAGTTACTTGGGCGGGGCCGGTAGCGGCGGGAGCTGCACTGGCCAGGGGTTCCGGCTGTATATCCATGAGCGCCGCTGGCAGCCGGGGA GCTGCAGGAACCAGACTGGGGGCGAGCTGAGCACCTGTAGTCAATCACACGCAGCTTTTAGGTTTGTTTGAATAAGAGATCTGACCTGAC CGGCCCAACTGTACAACTCTTCAAGGAAAATTCGTATTTGCAGTGGGAAGAATAAGTAACATTGATCAAGATGAATGCCATGCTGGAGAC TCCCGAACTCCCAGCCGTGTTTGATGGAGTGAAGCTGGCTGCAGTGGCTGCTGTGCTGTACGTGATCGTCCGGTGTTTGAACCTGAAGAG CCCCACAGCCCCACCTGACCTCTACTTCCAGGACTCGGGGCTCTCACGCTTTCTGCTCAAGTCCTGTCCTCTTCTGACCAAAGAATACAT TCCACCGTTGATCTGGGGGAAAAGTGGACACATCCAGACAGCCTTGTATGGGAAGATGGGAAGGGTGAGGTCGCCACATCCTTATGGGCA CCGGAAGTTCATCACTATGTCTGATGGAGCCACTTCTACATTCGACCTCTTCGAGCCCTTGGCTGAGCACTGTGTTGGAGATGATATCAC CATGGTCATCTGCCCTGGAATTGCCAATCACAGCGAGAAGCAATACATCCGCACTTTCGTTGACTACGCCCAGAAAAATGGCTATCGGTG CGCCGTGCTGAACCACCTGGGTGCCCTGCCCAACATTGAATTGACCTCGCCACGCATGTTCACCTATGGCTGCACGTGGGAATTTGGAGC CATGGTGAACTACATCAAGAAGACATATCCCCTGACCCAGCTGGTCGTCGTGGGCTTCAGCCTGGGTGGTAACATTGTGTGCAAATACTT GGGGGAGACTCAGGCAAACCAAGAGAAGGTCCTGTGCTGCGTCAGCGTGTGCCAGGGGTACAGTGCACTGAGGGCCCAGGAAACCTTCAT GCAATGGGATCAGTGCCGGCGGTTCTACAACTTCCTCATGGCTGACAACATGAAGAAGATCATCCTCTCGCACAGGCAAGCTCTTTTTGG AGACCATGTTAAGAAACCCCAGAGCCTGGAAGACACGGACTTGAGCCGGCTCTACACAGCAACATCCCTGATGCAGATTGATGACAATGT GATGAGGAAGTTTCACGGCTATAACTCCCTGAAGGAATACTATGAGGAAGAAAGTTGCATGCGGTACCTGCACAGGATTTATGTTCCTCT CATGCTGGTTAATGCAGCTGACGATCCGTTGGTGCATGAAAGTCTTCTAACCATTCCAAAATCTCTTTCAGAGAAACGAGAGAACGTCAT GTTTGTGCTGCCTCTGCATGGGGGCCACTTGGGCTTCTTTGAGGGCTCTGTGCTGTTCCCCGAGCCCCTGACATGGATGGATAAGCTGGT GGTGGAGTACGCCAACGCCATTTGCCAATGGGAGCGTAACAAGTTGCAGTGCTCTGACACGGAGCAGGTGGAGGCCGACCTGGAGTGAGG CCTCCGGACTCTGGCACGCTCCAGCAGCCCTCCTCTGGAAGCTGCGTCCCCTCACCCCCTGTTTCAGGTCTCCCATCTCCCTCAGTGACC TGGATCTGACCTCACACCATCAGCAGGGGGCACCCACCATGCACACCTGTCTCGGAGTAGGCAGCTCTTCCTGGGAGCTCCAGGCTATTT TTGTGCTTAGTTACTGGTTTTCTCCATTGCATTGTTAGGCATGGTGACAAGTGACAGAGTTCTTGCCCTCTGTCCAGTTTCAGCATCTGG TTGCTTTTAAGCCAAGTACATCTAGTTTCCCTATTAAAAATGTGTCTGAATAGCGATTTTGCTTTGCCACCAAAAGGCTTTTCCCTGAGA ACAGTGAAGGATGTATGTCATTTTGTGGTGGTTGTATGTGTCCTTACATAGACCTTAAAAAGAGCTCACCCTTCCAGGCCAATGCTGAAG ACACAGCTCCGCTTGGGAGCCTGAGAACCCAGGCTTCCCAGGCCAGAGTGTGGCTTCTTAAACGGCAAAGGAAATTCCTTTGAGTCACAA GCCAAGTTTTCGCCCTGTCTCCTGAGACCATTTCCCTACGCTTTGCTGCTGCTGAGAGTTACGTGAGGCACTTGTTAAAAATTCAGCCTC CCAGGTCCCTCCCCTCGGAGAGGCTGATTCACTGGGTCTGGGAAGGAGCCTGGGGATTTTAATTTTTCACAAGTGCCCCAGATGATTCTC ATCACCAAGCAAATTTTGGAAATGCTGTTCAACAGCGCCCTTAAATTGGAAACATCTTTGCAGCTCGTTTTATTGAAATTCATAATCAGG GGTGTCCTCTAGCTCCCACGGTCTCCAGAGCAGCAAGGCCGGCTATGGAGCTGCCGTCGTGTGACCACAGTGTGATGTCTCAGAAGGGCT CTGGGTGGGCTGAGCATCTGGGCTGTGCCCTGGCTCTGCTTTTCACCCTGGACAAAGTCGCTGTGGACTTCAATTTCTTCACCTCTAAAA TGGGGGACTTGGACCAGGTAGATTGCTGAGCTCACTACCAGGTTCAAAGTTCAATGACAAACTCAGTTTACTGAGGTTTGAGAGAACATC CCTCCAGGGGAGCCTGGGAGCTGCTCTCCCAGTCTAAGCATGTAGATATCATCGTTTGCCTTTTGTGTGTGTGTGTCCCTTATTTGATAA AAAGATGTTTTGAGTTGTTTTTTTTTTAAGCACTCACTTGTAATTTTAGTTTTTAAACCCAAGTCCCTCTAACTTTGCCTTTGATACCAA ACAATTCAAAAGTTGGATCTGAGTTTGGAGAAAGATATTTCCAACCTAAGTGGGTATTATTTTGAAACCAGATTTTTAATTTAATAGCCT ATATTTGTAGTCTGTTGGATAGGTGTTTCCAAAGTGTGTCTTCTCAAGTGAAAACGCAACTCTAGGTTTCAAGTACTCCTTTTCTCCGAT CCTGTGGTACTTGAATATCCAAAAACCCTGCACTTTGAACAATCAGCTGTTGCTATCTGGAACTAAACAGAACTATGAGTAAAATTGCCT GGATACTTTAAAAAGATATTTTTCCTCCTTCATCTCCTTTGACTCCAGGACAGACTGGAATATAAGTAGTGGGTCTGCATGGATGTTTCA GGGATCAAAGGAGCCACCTGGGCGCCTGAGTGCCAACCCTCAGGGCCACAGGTGGGTGTGGTTTGGGCACGGGTCCAAGTGACTGTGACG GGACCCGTGGGCATGGGTCCAGGTCTGTAACCTGAAGAAGTTGTTTTCTGACAATCACCAAATCATCCGAATGACATCAAAAGCAGCCCT TATCTCAGAGACTGAGATTTCTGTGGTCTCAACTTCGCTTTGGTATAATTTCTGGCACTCACCAGCCTCTATCATTATGACTTTCCCCCC AGTGTATTATTTCTCTAATAGGTTTCCTTTTCACGTTCTTTTAGCACAGACTGGCACTTTACCCTCTCAGTTTGGAAGTTAGCCCCTCTC CTCTGTTACTTTTCCCTTCACCCAACTACAGCTGTGATCTAGAACATTCATAGTCATATTTCTGCTACTACTACCTTCATTTATCAAGAC TTTTTATGAGAATAGGTAAACCAAGCAATAACTTCCTAGGACTGAATCACCACCCCAGAAGAGCGAGAGGCTCCTTTCATATGCCTGAGG CCACACCCCTTAACCTGTTCTGACAAAATAGTGGCTGGCCCATGTACCAGCTCCATTCAGAAATTCAGGAAGAGAAAAGACAGCCCTGTT GTCACACAAACCGGTGTGGGGGAGGGTGGAGCCTGGTCTGCACGGCAGTCCTGGTGGCCCCTGTGGAGGACAGGCAGGGCTGGCAGCATA GCCTTTGTTGCCACACAACCGGAATTTGCTCCCCCAGGACTGTGGGAGCCAGTGTCCCAGCTGAAATCTTTTTAGTGTGTGGCTCTGAAT GGCACTCACATTCCATTTTGGCTCACATGAAACTAACTGAAGCCCTTTGTTCAAGCTTCAGGCTCTTAGGCATGGAAATGAGAATGTGAC TGTGGCTGTCTTACAGGAAAATTCTTGTTTGTCCCTGAATGAGAGCACAGAGGCATTGAATTCACAGAGCTGCAAACTTGCCTGATAAAT GAGGGAGTGGCAGTTTATAGATAGGTCATCTTTTTTCCTTCCTCCAGGTGTCCTTGCCTTTCTTCCCAAAGTCATTCATTTCTGATGAGT ATATGAATCCCCCTCTTGCTAGTAAGGTTCTATTTGGGCTAAAACAAGGCTGAATTTTTAAAGAGTATTTGAATATATTTTAGAATCAAA TTGAGGCTATAAATTGCATCAATCTGGACAATTCCATTGCAGGAATAATATGTTAAAAACCAATGGGGAGAAGCACCCACATCTCTCCTG TAGCACTCCGTGTCTCATAAGCAATTTGAAGACACTTACAAGTAACTGATTCCAGTCAAATTAGGATTAACTGACTCAAAAAATGGTGTC AAGTTTCTTTAATGTTTTTATGTTAGAAGTGAGTTTAACAGACTTGAAGAAAACTGTTATCTTTTCCTGCTGTGAGTTTACACAAATGAT TCCAGAGCAGAATGAAAGCAGAAAGCTGTTGGTTACAATATTCTTTTAACCTCTCTGCAGCATTTTACACTTACTGGGAACCTTATGATT CACCGTAAGAGTGGAAATATACCTGAGTTCGTGTCCTAATGGTCTCTAATTCACATTGGATCGTGGGCAAATCACCTCACCTCTCTGAGC CTGTTCCCTCCTCTTAGACCATCTCTAAGACCACTTCATCTATTTACACATCATTTGCTTGAACATTGCTGAACATCTGCGTGAACTTGG CCTCTCCAGCCCTTGCAGGTGGAAACAGCTGTGTCAAGGCTCAAGGCTCACGCTGAGGGGACTTGGAGGGAGGGGGCTTCTGCATTAAGC TTTCCTGGTGAAGACCCTTGATCTTGTCCAAAGCCCTGTGTCTTTGACTGGCTTCTCTTCAGAGTCCCCGTTGTCATCGTAAGACCCTTG CTGTTTGGAGGGTGGTCTTGTGACTGTGGCAGCTGCTGGCCGCTGGAATGAGGAGCCTATCTCCATCCTCCAGTGTGACTCAGGCAGAGC ATTGAGAATTCCCAGGGCAGAAATCCTTCCTGCTCAGGCTTTCATTCTAAAACTACAGTCTTCATTAAAGCTGAACTTTCTGGGTAGCTG AGCTTATATGCCCGGCATCTGAATGAGAGCTCTCTTTGTAACTGTGTGACTTGAGATCTAGTTTGCCAGCTCCTGGGAAACAATACATGT GTTCTTGTTTGTGTTTGCTCAGCAAGCAGATGTCTGAGATGTAAGAAGCTTTTCTTTTCCTGTGGCATTGATTCTGACTTAGAGCTGAAG TAAAAGATCACTGAAACATCACGTCAAGTTGAAGTCACTCATAGGTCTTTGTCCTTTAGGCAGGACAGGAGAGTCATTAAGAAGCATTTC ACTGTAGCATTCTATCACAATATCATCTGGAATTGTTTTCTTTGCCCAGAAAGCCTTAACTTGCCTCTAGAGAATCCCTGGTATTACAAC GATATTGCGGCATTAGAATTCCAACTCTTCTGCTGTGGAAGTTTGAAGCGAAGCTGCAGCAAAACCAGAGAATTTCCTCAAGTGGCCTGT AGGCTCCTTGTTATCTTATGCCCCCACCCCTCCCTCAACAATATGAGTGATCCAGAACTGGCCCAAACACCTCAGCTCTGGTCCCTTTTT GCCCTTCTTGGCCTTACTCTGTTGTTCAAAGCCACTTTGGATTGCTTGGATGCTTCGAACAGCCATGAAAAGTAGCCTGCCTGTGGCATT TAGAGGCCAAGCAATTGACAGAAAGGGTTTCTTCTACCTCTGTTATCTAAGCAGAGGGAAGTAAACCTCTCACCGCCCCCCACCCCTCAC TGCCCCCGATTACCCTAGAATTGCTTTCGCCAAATTGTAGTTGAAGCTAAGGAAGGGGAATCTGGCCCCTGCTGGGAGAGGGAACTGGAA TGCCACACAAGGCAAGGCCTGCTTCCTTCCTTCCCCTCTGCTGCTGCTGCCTCGGAACGCTGCAGCCCAGGCTTCCTCCCACAGTGGCCC TTGGAAGCAGGCCGCAGAGTAGACAGCTGCTCCTTTTGGAAGAGTCAGTCCCCTGTGTTTTCTGAACTGTTTTTCCTAGCATGTATGTGG GTAGAGCTTTCATGCATCTCTAGTAATAATAAGCTGAAATTAGTTTTTTTTTTAATTCTCCAATTTAAAACTTTTAATTAAAAAGTAAAT TTTAATGTCGAAAATGCAAACTTGGGGAGGGCAGAAAGATCACACACAAGGCTGTCACTTCATACTTGCAGGATTGCACAGCAGCCGGGC AGAGGCGCTCCTCACTTCCCAGATGGGGCGGCGGGCAGCAGAGACGCACCTCACTTCCTAGACAGTGCGGCAGCCAGGCACAGGCACACC TCACTTCCCAGACAGTTGGGCGGCCAGGCAAGCGCTCCTCACTTCCCAGATGGGGCGGCTCCCGGGAAGCGGGGCTCCTCACTTCCCAGA CAGGGTGGCCAGGCAGAGGTGCTCCTCACTTCCCAGAACAATTCTTTATGAATTTGATAAAGGACTGAAGTGCAACTGAAAGCTGCTAGT GATGATCTGGTAATATACAATTTGTCCAGTAGCCAGTTTGTTTTTATTGTGTTTTCTAACCATAAGAGATCATTAAAGGCAAAGCCTGTA TGACGCTGTACACACACAAAAAAATGGTCACCGCAGGCCATACTACCAATGAAATGGTAGGTAAACAAATCTTCTGGTCAAGAGAAAAAA AAAAGAAATAGCACTCTGCATGCTTTGCTCTACAAGACGAATTTCCCTAGAAAGAATCCAATGAAGGCCGGGCATAGTGGCTCACTCCTG TAATCCCAGCACTTTGGAGGCCGAGGCGGGTAGATCACCTGAGGTTAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCTTCTC TACTAAAAATGCAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGTGGGAGAATTGCTTGAACC CAGGAGACGGAGGTTGCAGTGAGCCGAGATCACGCCTCTGCACTCCAGCCTGGGCAACAAGAGTGAGACTCCGTCTCCAAAAAAAGAAAA GGAATCCAGTGAAAATGGCTGCAATTACAACAAGAAGTGAAGGAAGAAGACTGGTGACATCTCTGAAGGATGCAGTTGAGGTTGATCCAG GTTTATCCGAATATGCTACCTTTCTGAGCCTTAAACCTTCATCTCTCAGGTGTTGATTTGCTTCTGATAGCTTCATCATTTCTCCCTGAA GTCTTTTACACTCTTCTGTTAGTTTCCTTGTTTCAGTATCATGAAGTGAAGCACTGTGTGGTTGTGGCGTGGGCCCGTCTTGCTTAGATG CATTCAGTGGGACAGCTTTGCTGGGTTCCATGTCATTCAATTTATCATTTTCATTGGGGATCTCCATTTGGAATCCATTAATTCATGAGG TTTTGCCTCATTCCACACAGCTTCCATATCTGAAGTGTTTAGTGGAGCAAAAATTGTACCATAAACTTGTGTTTACTCTTTTCATTCGGA TCATAGTCAAAGGGCTGTAGCATTACTGAAACAGTCACAGTTGACCCTGGGTCAATAATTCCACTGTTGGGCCTCACACAGTACCGGTGA GGCACGGTAGTCTTCACTTTGAAACACACTTTTCTATCCGATGGATTTCGCAATTTAAGATTTGTAGTGACTACATCTGTGAAGGGGCCT TTGAATTTGAGGTCTATGGGCGGGTCGAGGACCAGGATCTGCTCGTGCTTCGCCGTGGCCCCGGAGGCAGACGCCATTGGAGAGACAGCG CAGAGCAGGGGGCGGCTTGCTCGCTGGGGGCGGGGGACGATGGCGAGAGGGGAGGGGGAGCGAGTTCGCATCTCTCCTTTTCCTGGTTAG ACTCTGTTCAACCACATTCTTATGTTGGCAGATCTGCTTCCAGATTGATTTTTAGAGCACCATCACTTTCACATTCCTGATTCTGATTTT GTTTTGTTTTGTTTGGGTTTTCTGAAACTTAAAATGCTGCCCCGAAAATACTATATTTTTGAGTTTGTGTTCTGAAAGCCTCCGTGCTGC TGGATCTTTGGGGGGAAATACAGGATCCTTCAGCACTGAGGTGTTTAAGATTTGCAACTAGCAATGCAATTTTTTCTAAATATGGGGATA TTTACCTTTATTAAGAAATTATACTAAACATTGATGTCCTTGATCATTTTATGTTCTCATATTACTTTTGATTCTACTATGATTGTGTGG TGGTGAACAAAGATCATTACAAACAAAAACTGTAATTTTGTTATATTTGATTCAATGGAATTTACCTAAAAAATAAAGACTAAAAATGTG GTGTGAAAAAAAACTGGGTGAATACTCCAAGAAGGCGGCTATGAAACCCAAACCTTTGTCAGTATTAAAGTCACTTGAAGAAAAATATGT GGCTGTTATGAAGAAATTACAGTTTGATACGTTTGAAATGGTTTCTGAAGATGAAGATGGGAAATTGGGATTTAAAGTAAATTACCACTA CATGTCTCAGGTGAAAAATGCTAATGATGCGAACAGTGCTGCCAGAGCTCGCCGCCTTGCCCAGGAAGCTGTGACGCTTTCAACCTCACT GCCTCTGTCTTCATCCTCTAGTGTGTTTGTACGCTGTGATGAGGAGCGACTTGATATCATGAAGGTTCTAATAACTGGTCCAGCGGACAC CCCTTATGCAAATGGCTGCTTTGAGTTTGATGTGTATTTTCCTCAAGATTATCCCAGTTCACCCCCTCTTGTGAATCTAGAGACAACTGG TGGTCATAGCGTGCGATTCAATCCAAACCTTTATAATGATGGCAAGGTTTGTTTAAGCATCTTAAACACGTGGCATGGAAGACCAGAAGA GAAGTGGAATCCTCAGACCTCAAGCTTTTTGCAAGTGTTGGTGTCTGTCCAGTCCCTTATATTAGTAGCTGAGCCTTATTTTAATGAACC GGGATATGAACGGTCTAGAGGCACTCCCAGTGGCACACAGAGTTCTCGAGAATATGATGGAAACATTCGACAAGCAACAGTTAAGTGGGC AATGCTAGAACAAATCAGAAACCCTTCACCATGTTTTAAAGAGGTAATACACAAACATTTTTACTTGAAAAGAGTTGAGATAATGGCCCA ATGTGAGGAGTGGATTGCGGATATCCAGCAGTACAGCAGTGATAAGCGGGTAGGCAGGACTATGTCTCACCATGCAGCAGCTCTCAAGCG TCACACTGCTCAGCTCCGCGAAGAGTTGCTGAAACTTCCCTGCCCTGAAGGCTTGGATCCTGACACTGACGATGCCCCAGAGGTGTGCAG AGCCACAACAGGTGCTGAGGAGACTCTAATGCATGATCAGGTTAAACCCAGCAGCAGCAAAGAACTCCCCAGTGACTTCCAGTTATGAGC TGCATTGATGTGGACTTCATAGACACAAAGGCTTCGAAGCACAAGCCAAATATGTCAATATTTGTATGTAAGAAACTAATTATGTAATAG GTAATGAAACTGAAACTATACTATGCCCTTAAGGAGATCCAGTTTAATTCAAGGTGATCTTTTATTTACCTGTACAGGAGTGTAAACTTT TTTGTGCTTTTATTTTTCAATTGTGAGAACCACTGATTGGTATGTTCAACAAATTTGTGTATACAAAGAAATGGATAAATCACTGCTATA TAAGGGAAACTACCTTAGGAAAGAATGTTTACTGAATGTTTATTTTATTTTATTTTTTTTTTACTATAGAGTGAGGGGTTGTTAACAAAG AATATATATTGGTCATTCTTACAACTACTATTTAAAGTCAGCAACTTTTCACTGAATTTGATAGATTTTATGTTTGGCCATATCTTCATG CTCACATTTGATTTCTGAAGACCTCCTACATACACTTCAATAAAAGTTAAATGGACATACTCCCTCTTTTTTGATTTACTGGTACATTTT TAAAATAATAAATCTGCCATAAAATGCATTATATCTGGAGACTTGCACTTGTATGGATGAATTTATTACATTCAACATATTTAATTTTAT GCCTTCTAATTCTAAGATGCAGAAAAAAATAAATGAACATGATTTTATTCTATGCCAACATTTGGGCCTCTGAATGTATCTGTTATTTGA ATTTAAGTATTTGAAAAGGAATGGTCAATTTGAAAGTCATTCTAAACTGATTTTTTTTTTCTAAAGGGCTCCTTTTTTCCTGGACTATGT GGTTTTATGACTAAAGTCACATGTATGTATTAAACATTGAGGCTCTGTAGAGGAGAGAGGATGTACCTCTCTGGTGCTGTTACAGTACAT TCTGTACCTGCCATACAGGCTCATTTTCATGCAAATTCTTCCTAGAGCCAAATAAATAAAGACTTAGGTGAATTAGTATGTCTTGTTTCT >419_419_1_ABHD2-BIRC6_ABHD2_chr15_89745591_ENST00000352732_BIRC6_chr2_32820101_ENST00000421745_length(amino acids)=428AA_BP= MIKMNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMG RVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDITMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVLNHLGALPNIELTSPRMF TYGCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKI ILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPK -------------------------------------------------------------- >419_419_2_ABHD2-BIRC6_ABHD2_chr15_89745591_ENST00000355100_BIRC6_chr2_32820101_ENST00000421745_length(transcript)=10756nt_BP=8688nt TGTCAGGAGGGCGTAGTTTGCAAAACATCCCTCCCAGTGGTACTGATGCCTTTTCGCAGGTTCTGTCCTCTTCATTTGCAAGCCACTGCT TTATCCACGAGGGTGCTCCCTACTTATGCCAGTGAATTAATTTTTGGCACAGATGAATCCTTCATATTTATCTGGATTTAGCTGGTAGCA TTTGTCTCCTAAGACTTGGTCACAGAGGAATCCATGTGACCTTCAGGCCTTCTGCTCTAAACTGGCAGGAGATCCTGTTTCTACTCACAG CGTCCGAGGGTCTGGTGGCCGAGCCCTGAGGGGCGCTGTTGCTCCCAGGTGGCAGAATTCAGCATCAGAGAGCCACACAGCTGAAAGAGA TGGATGGCTTTTAGGTTTGTTTGAATAAGAGATCTGACCTGACCGGCCCAACTGTACAACTCTTCAAGGAAAATTCGTATTTGCAGTGGG AAGAATAAGTAACATTGATCAAGATGAATGCCATGCTGGAGACTCCCGAACTCCCAGCCGTGTTTGATGGAGTGAAGCTGGCTGCAGTGG CTGCTGTGCTGTACGTGATCGTCCGGTGTTTGAACCTGAAGAGCCCCACAGCCCCACCTGACCTCTACTTCCAGGACTCGGGGCTCTCAC GCTTTCTGCTCAAGTCCTGTCCTCTTCTGACCAAAGAATACATTCCACCGTTGATCTGGGGGAAAAGTGGACACATCCAGACAGCCTTGT ATGGGAAGATGGGAAGGGTGAGGTCGCCACATCCTTATGGGCACCGGAAGTTCATCACTATGTCTGATGGAGCCACTTCTACATTCGACC TCTTCGAGCCCTTGGCTGAGCACTGTGTTGGAGATGATATCACCATGGTCATCTGCCCTGGAATTGCCAATCACAGCGAGAAGCAATACA TCCGCACTTTCGTTGACTACGCCCAGAAAAATGGCTATCGGTGCGCCGTGCTGAACCACCTGGGTGCCCTGCCCAACATTGAATTGACCT CGCCACGCATGTTCACCTATGGCTGCACGTGGGAATTTGGAGCCATGGTGAACTACATCAAGAAGACATATCCCCTGACCCAGCTGGTCG TCGTGGGCTTCAGCCTGGGTGGTAACATTGTGTGCAAATACTTGGGGGAGACTCAGGCAAACCAAGAGAAGGTCCTGTGCTGCGTCAGCG TGTGCCAGGGGTACAGTGCACTGAGGGCCCAGGAAACCTTCATGCAATGGGATCAGTGCCGGCGGTTCTACAACTTCCTCATGGCTGACA ACATGAAGAAGATCATCCTCTCGCACAGGCAAGCTCTTTTTGGAGACCATGTTAAGAAACCCCAGAGCCTGGAAGACACGGACTTGAGCC GGCTCTACACAGCAACATCCCTGATGCAGATTGATGACAATGTGATGAGGAAGTTTCACGGCTATAACTCCCTGAAGGAATACTATGAGG AAGAAAGTTGCATGCGGTACCTGCACAGGATTTATGTTCCTCTCATGCTGGTTAATGCAGCTGACGATCCGTTGGTGCATGAAAGTCTTC TAACCATTCCAAAATCTCTTTCAGAGAAACGAGAGAACGTCATGTTTGTGCTGCCTCTGCATGGGGGCCACTTGGGCTTCTTTGAGGGCT CTGTGCTGTTCCCCGAGCCCCTGACATGGATGGATAAGCTGGTGGTGGAGTACGCCAACGCCATTTGCCAATGGGAGCGTAACAAGTTGC AGTGCTCTGACACGGAGCAGGTGGAGGCCGACCTGGAGTGAGGCCTCCGGACTCTGGCACGCTCCAGCAGCCCTCCTCTGGAAGCTGCGT CCCCTCACCCCCTGTTTCAGGTCTCCCATCTCCCTCAGTGACCTGGATCTGACCTCACACCATCAGCAGGGGGCACCCACCATGCACACC TGTCTCGGAGTAGGCAGCTCTTCCTGGGAGCTCCAGGCTATTTTTGTGCTTAGTTACTGGTTTTCTCCATTGCATTGTTAGGCATGGTGA CAAGTGACAGAGTTCTTGCCCTCTGTCCAGTTTCAGCATCTGGTTGCTTTTAAGCCAAGTACATCTAGTTTCCCTATTAAAAATGTGTCT GAATAGCGATTTTGCTTTGCCACCAAAAGGCTTTTCCCTGAGAACAGTGAAGGATGTATGTCATTTTGTGGTGGTTGTATGTGTCCTTAC ATAGACCTTAAAAAGAGCTCACCCTTCCAGGCCAATGCTGAAGACACAGCTCCGCTTGGGAGCCTGAGAACCCAGGCTTCCCAGGCCAGA GTGTGGCTTCTTAAACGGCAAAGGAAATTCCTTTGAGTCACAAGCCAAGTTTTCGCCCTGTCTCCTGAGACCATTTCCCTACGCTTTGCT GCTGCTGAGAGTTACGTGAGGCACTTGTTAAAAATTCAGCCTCCCAGGTCCCTCCCCTCGGAGAGGCTGATTCACTGGGTCTGGGAAGGA GCCTGGGGATTTTAATTTTTCACAAGTGCCCCAGATGATTCTCATCACCAAGCAAATTTTGGAAATGCTGTTCAACAGCGCCCTTAAATT GGAAACATCTTTGCAGCTCGTTTTATTGAAATTCATAATCAGGGGTGTCCTCTAGCTCCCACGGTCTCCAGAGCAGCAAGGCCGGCTATG GAGCTGCCGTCGTGTGACCACAGTGTGATGTCTCAGAAGGGCTCTGGGTGGGCTGAGCATCTGGGCTGTGCCCTGGCTCTGCTTTTCACC CTGGACAAAGTCGCTGTGGACTTCAATTTCTTCACCTCTAAAATGGGGGACTTGGACCAGGTAGATTGCTGAGCTCACTACCAGGTTCAA AGTTCAATGACAAACTCAGTTTACTGAGGTTTGAGAGAACATCCCTCCAGGGGAGCCTGGGAGCTGCTCTCCCAGTCTAAGCATGTAGAT ATCATCGTTTGCCTTTTGTGTGTGTGTGTCCCTTATTTGATAAAAAGATGTTTTGAGTTGTTTTTTTTTTAAGCACTCACTTGTAATTTT AGTTTTTAAACCCAAGTCCCTCTAACTTTGCCTTTGATACCAAACAATTCAAAAGTTGGATCTGAGTTTGGAGAAAGATATTTCCAACCT AAGTGGGTATTATTTTGAAACCAGATTTTTAATTTAATAGCCTATATTTGTAGTCTGTTGGATAGGTGTTTCCAAAGTGTGTCTTCTCAA GTGAAAACGCAACTCTAGGTTTCAAGTACTCCTTTTCTCCGATCCTGTGGTACTTGAATATCCAAAAACCCTGCACTTTGAACAATCAGC TGTTGCTATCTGGAACTAAACAGAACTATGAGTAAAATTGCCTGGATACTTTAAAAAGATATTTTTCCTCCTTCATCTCCTTTGACTCCA GGACAGACTGGAATATAAGTAGTGGGTCTGCATGGATGTTTCAGGGATCAAAGGAGCCACCTGGGCGCCTGAGTGCCAACCCTCAGGGCC ACAGGTGGGTGTGGTTTGGGCACGGGTCCAAGTGACTGTGACGGGACCCGTGGGCATGGGTCCAGGTCTGTAACCTGAAGAAGTTGTTTT CTGACAATCACCAAATCATCCGAATGACATCAAAAGCAGCCCTTATCTCAGAGACTGAGATTTCTGTGGTCTCAACTTCGCTTTGGTATA ATTTCTGGCACTCACCAGCCTCTATCATTATGACTTTCCCCCCAGTGTATTATTTCTCTAATAGGTTTCCTTTTCACGTTCTTTTAGCAC AGACTGGCACTTTACCCTCTCAGTTTGGAAGTTAGCCCCTCTCCTCTGTTACTTTTCCCTTCACCCAACTACAGCTGTGATCTAGAACAT TCATAGTCATATTTCTGCTACTACTACCTTCATTTATCAAGACTTTTTATGAGAATAGGTAAACCAAGCAATAACTTCCTAGGACTGAAT CACCACCCCAGAAGAGCGAGAGGCTCCTTTCATATGCCTGAGGCCACACCCCTTAACCTGTTCTGACAAAATAGTGGCTGGCCCATGTAC CAGCTCCATTCAGAAATTCAGGAAGAGAAAAGACAGCCCTGTTGTCACACAAACCGGTGTGGGGGAGGGTGGAGCCTGGTCTGCACGGCA GTCCTGGTGGCCCCTGTGGAGGACAGGCAGGGCTGGCAGCATAGCCTTTGTTGCCACACAACCGGAATTTGCTCCCCCAGGACTGTGGGA GCCAGTGTCCCAGCTGAAATCTTTTTAGTGTGTGGCTCTGAATGGCACTCACATTCCATTTTGGCTCACATGAAACTAACTGAAGCCCTT TGTTCAAGCTTCAGGCTCTTAGGCATGGAAATGAGAATGTGACTGTGGCTGTCTTACAGGAAAATTCTTGTTTGTCCCTGAATGAGAGCA CAGAGGCATTGAATTCACAGAGCTGCAAACTTGCCTGATAAATGAGGGAGTGGCAGTTTATAGATAGGTCATCTTTTTTCCTTCCTCCAG GTGTCCTTGCCTTTCTTCCCAAAGTCATTCATTTCTGATGAGTATATGAATCCCCCTCTTGCTAGTAAGGTTCTATTTGGGCTAAAACAA GGCTGAATTTTTAAAGAGTATTTGAATATATTTTAGAATCAAATTGAGGCTATAAATTGCATCAATCTGGACAATTCCATTGCAGGAATA ATATGTTAAAAACCAATGGGGAGAAGCACCCACATCTCTCCTGTAGCACTCCGTGTCTCATAAGCAATTTGAAGACACTTACAAGTAACT GATTCCAGTCAAATTAGGATTAACTGACTCAAAAAATGGTGTCAAGTTTCTTTAATGTTTTTATGTTAGAAGTGAGTTTAACAGACTTGA AGAAAACTGTTATCTTTTCCTGCTGTGAGTTTACACAAATGATTCCAGAGCAGAATGAAAGCAGAAAGCTGTTGGTTACAATATTCTTTT AACCTCTCTGCAGCATTTTACACTTACTGGGAACCTTATGATTCACCGTAAGAGTGGAAATATACCTGAGTTCGTGTCCTAATGGTCTCT AATTCACATTGGATCGTGGGCAAATCACCTCACCTCTCTGAGCCTGTTCCCTCCTCTTAGACCATCTCTAAGACCACTTCATCTATTTAC ACATCATTTGCTTGAACATTGCTGAACATCTGCGTGAACTTGGCCTCTCCAGCCCTTGCAGGTGGAAACAGCTGTGTCAAGGCTCAAGGC TCACGCTGAGGGGACTTGGAGGGAGGGGGCTTCTGCATTAAGCTTTCCTGGTGAAGACCCTTGATCTTGTCCAAAGCCCTGTGTCTTTGA CTGGCTTCTCTTCAGAGTCCCCGTTGTCATCGTAAGACCCTTGCTGTTTGGAGGGTGGTCTTGTGACTGTGGCAGCTGCTGGCCGCTGGA ATGAGGAGCCTATCTCCATCCTCCAGTGTGACTCAGGCAGAGCATTGAGAATTCCCAGGGCAGAAATCCTTCCTGCTCAGGCTTTCATTC TAAAACTACAGTCTTCATTAAAGCTGAACTTTCTGGGTAGCTGAGCTTATATGCCCGGCATCTGAATGAGAGCTCTCTTTGTAACTGTGT GACTTGAGATCTAGTTTGCCAGCTCCTGGGAAACAATACATGTGTTCTTGTTTGTGTTTGCTCAGCAAGCAGATGTCTGAGATGTAAGAA GCTTTTCTTTTCCTGTGGCATTGATTCTGACTTAGAGCTGAAGTAAAAGATCACTGAAACATCACGTCAAGTTGAAGTCACTCATAGGTC TTTGTCCTTTAGGCAGGACAGGAGAGTCATTAAGAAGCATTTCACTGTAGCATTCTATCACAATATCATCTGGAATTGTTTTCTTTGCCC AGAAAGCCTTAACTTGCCTCTAGAGAATCCCTGGTATTACAACGATATTGCGGCATTAGAATTCCAACTCTTCTGCTGTGGAAGTTTGAA GCGAAGCTGCAGCAAAACCAGAGAATTTCCTCAAGTGGCCTGTAGGCTCCTTGTTATCTTATGCCCCCACCCCTCCCTCAACAATATGAG TGATCCAGAACTGGCCCAAACACCTCAGCTCTGGTCCCTTTTTGCCCTTCTTGGCCTTACTCTGTTGTTCAAAGCCACTTTGGATTGCTT GGATGCTTCGAACAGCCATGAAAAGTAGCCTGCCTGTGGCATTTAGAGGCCAAGCAATTGACAGAAAGGGTTTCTTCTACCTCTGTTATC TAAGCAGAGGGAAGTAAACCTCTCACCGCCCCCCACCCCTCACTGCCCCCGATTACCCTAGAATTGCTTTCGCCAAATTGTAGTTGAAGC TAAGGAAGGGGAATCTGGCCCCTGCTGGGAGAGGGAACTGGAATGCCACACAAGGCAAGGCCTGCTTCCTTCCTTCCCCTCTGCTGCTGC TGCCTCGGAACGCTGCAGCCCAGGCTTCCTCCCACAGTGGCCCTTGGAAGCAGGCCGCAGAGTAGACAGCTGCTCCTTTTGGAAGAGTCA GTCCCCTGTGTTTTCTGAACTGTTTTTCCTAGCATGTATGTGGGTAGAGCTTTCATGCATCTCTAGTAATAATAAGCTGAAATTAGTTTT TTTTTTAATTCTCCAATTTAAAACTTTTAATTAAAAAGTAAATTTTAATGTCGAAAATGCAAACTTGGGGAGGGCAGAAAGATCACACAC AAGGCTGTCACTTCATACTTGCAGGATTGCACAGCAGCCGGGCAGAGGCGCTCCTCACTTCCCAGATGGGGCGGCGGGCAGCAGAGACGC ACCTCACTTCCTAGACAGTGCGGCAGCCAGGCACAGGCACACCTCACTTCCCAGACAGTTGGGCGGCCAGGCAAGCGCTCCTCACTTCCC AGATGGGGCGGCTCCCGGGAAGCGGGGCTCCTCACTTCCCAGACAGGGTGGCCAGGCAGAGGTGCTCCTCACTTCCCAGAACAATTCTTT ATGAATTTGATAAAGGACTGAAGTGCAACTGAAAGCTGCTAGTGATGATCTGGTAATATACAATTTGTCCAGTAGCCAGTTTGTTTTTAT TGTGTTTTCTAACCATAAGAGATCATTAAAGGCAAAGCCTGTATGACGCTGTACACACACAAAAAAATGGTCACCGCAGGCCATACTACC AATGAAATGGTAGGTAAACAAATCTTCTGGTCAAGAGAAAAAAAAAAGAAATAGCACTCTGCATGCTTTGCTCTACAAGACGAATTTCCC TAGAAAGAATCCAATGAAGGCCGGGCATAGTGGCTCACTCCTGTAATCCCAGCACTTTGGAGGCCGAGGCGGGTAGATCACCTGAGGTTA GGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCTTCTCTACTAAAAATGCAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTGTAA TCCCAGCTACTCGGGAGGCTGAGGTGGGAGAATTGCTTGAACCCAGGAGACGGAGGTTGCAGTGAGCCGAGATCACGCCTCTGCACTCCA GCCTGGGCAACAAGAGTGAGACTCCGTCTCCAAAAAAAGAAAAGGAATCCAGTGAAAATGGCTGCAATTACAACAAGAAGTGAAGGAAGA AGACTGGTGACATCTCTGAAGGATGCAGTTGAGGTTGATCCAGGTTTATCCGAATATGCTACCTTTCTGAGCCTTAAACCTTCATCTCTC AGGTGTTGATTTGCTTCTGATAGCTTCATCATTTCTCCCTGAAGTCTTTTACACTCTTCTGTTAGTTTCCTTGTTTCAGTATCATGAAGT GAAGCACTGTGTGGTTGTGGCGTGGGCCCGTCTTGCTTAGATGCATTCAGTGGGACAGCTTTGCTGGGTTCCATGTCATTCAATTTATCA TTTTCATTGGGGATCTCCATTTGGAATCCATTAATTCATGAGGTTTTGCCTCATTCCACACAGCTTCCATATCTGAAGTGTTTAGTGGAG CAAAAATTGTACCATAAACTTGTGTTTACTCTTTTCATTCGGATCATAGTCAAAGGGCTGTAGCATTACTGAAACAGTCACAGTTGACCC TGGGTCAATAATTCCACTGTTGGGCCTCACACAGTACCGGTGAGGCACGGTAGTCTTCACTTTGAAACACACTTTTCTATCCGATGGATT TCGCAATTTAAGATTTGTAGTGACTACATCTGTGAAGGGGCCTTTGAATTTGAGGTCTATGGGCGGGTCGAGGACCAGGATCTGCTCGTG CTTCGCCGTGGCCCCGGAGGCAGACGCCATTGGAGAGACAGCGCAGAGCAGGGGGCGGCTTGCTCGCTGGGGGCGGGGGACGATGGCGAG AGGGGAGGGGGAGCGAGTTCGCATCTCTCCTTTTCCTGGTTAGACTCTGTTCAACCACATTCTTATGTTGGCAGATCTGCTTCCAGATTG ATTTTTAGAGCACCATCACTTTCACATTCCTGATTCTGATTTTGTTTTGTTTTGTTTGGGTTTTCTGAAACTTAAAATGCTGCCCCGAAA ATACTATATTTTTGAGTTTGTGTTCTGAAAGCCTCCGTGCTGCTGGATCTTTGGGGGGAAATACAGGATCCTTCAGCACTGAGGTGTTTA AGATTTGCAACTAGCAATGCAATTTTTTCTAAATATGGGGATATTTACCTTTATTAAGAAATTATACTAAACATTGATGTCCTTGATCAT TTTATGTTCTCATATTACTTTTGATTCTACTATGATTGTGTGGTGGTGAACAAAGATCATTACAAACAAAAACTGTAATTTTGTTATATT TGATTCAATGGAATTTACCTAAAAAATAAAGACTAAAAATGTGGTGTGAAAAAAAACTGGGTGAATACTCCAAGAAGGCGGCTATGAAAC CCAAACCTTTGTCAGTATTAAAGTCACTTGAAGAAAAATATGTGGCTGTTATGAAGAAATTACAGTTTGATACGTTTGAAATGGTTTCTG AAGATGAAGATGGGAAATTGGGATTTAAAGTAAATTACCACTACATGTCTCAGGTGAAAAATGCTAATGATGCGAACAGTGCTGCCAGAG CTCGCCGCCTTGCCCAGGAAGCTGTGACGCTTTCAACCTCACTGCCTCTGTCTTCATCCTCTAGTGTGTTTGTACGCTGTGATGAGGAGC GACTTGATATCATGAAGGTTCTAATAACTGGTCCAGCGGACACCCCTTATGCAAATGGCTGCTTTGAGTTTGATGTGTATTTTCCTCAAG ATTATCCCAGTTCACCCCCTCTTGTGAATCTAGAGACAACTGGTGGTCATAGCGTGCGATTCAATCCAAACCTTTATAATGATGGCAAGG TTTGTTTAAGCATCTTAAACACGTGGCATGGAAGACCAGAAGAGAAGTGGAATCCTCAGACCTCAAGCTTTTTGCAAGTGTTGGTGTCTG TCCAGTCCCTTATATTAGTAGCTGAGCCTTATTTTAATGAACCGGGATATGAACGGTCTAGAGGCACTCCCAGTGGCACACAGAGTTCTC GAGAATATGATGGAAACATTCGACAAGCAACAGTTAAGTGGGCAATGCTAGAACAAATCAGAAACCCTTCACCATGTTTTAAAGAGGTAA TACACAAACATTTTTACTTGAAAAGAGTTGAGATAATGGCCCAATGTGAGGAGTGGATTGCGGATATCCAGCAGTACAGCAGTGATAAGC GGGTAGGCAGGACTATGTCTCACCATGCAGCAGCTCTCAAGCGTCACACTGCTCAGCTCCGCGAAGAGTTGCTGAAACTTCCCTGCCCTG AAGGCTTGGATCCTGACACTGACGATGCCCCAGAGGTGTGCAGAGCCACAACAGGTGCTGAGGAGACTCTAATGCATGATCAGGTTAAAC CCAGCAGCAGCAAAGAACTCCCCAGTGACTTCCAGTTATGAGCTGCATTGATGTGGACTTCATAGACACAAAGGCTTCGAAGCACAAGCC AAATATGTCAATATTTGTATGTAAGAAACTAATTATGTAATAGGTAATGAAACTGAAACTATACTATGCCCTTAAGGAGATCCAGTTTAA TTCAAGGTGATCTTTTATTTACCTGTACAGGAGTGTAAACTTTTTTGTGCTTTTATTTTTCAATTGTGAGAACCACTGATTGGTATGTTC AACAAATTTGTGTATACAAAGAAATGGATAAATCACTGCTATATAAGGGAAACTACCTTAGGAAAGAATGTTTACTGAATGTTTATTTTA TTTTATTTTTTTTTTACTATAGAGTGAGGGGTTGTTAACAAAGAATATATATTGGTCATTCTTACAACTACTATTTAAAGTCAGCAACTT TTCACTGAATTTGATAGATTTTATGTTTGGCCATATCTTCATGCTCACATTTGATTTCTGAAGACCTCCTACATACACTTCAATAAAAGT TAAATGGACATACTCCCTCTTTTTTGATTTACTGGTACATTTTTAAAATAATAAATCTGCCATAAAATGCATTATATCTGGAGACTTGCA CTTGTATGGATGAATTTATTACATTCAACATATTTAATTTTATGCCTTCTAATTCTAAGATGCAGAAAAAAATAAATGAACATGATTTTA TTCTATGCCAACATTTGGGCCTCTGAATGTATCTGTTATTTGAATTTAAGTATTTGAAAAGGAATGGTCAATTTGAAAGTCATTCTAAAC TGATTTTTTTTTTCTAAAGGGCTCCTTTTTTCCTGGACTATGTGGTTTTATGACTAAAGTCACATGTATGTATTAAACATTGAGGCTCTG TAGAGGAGAGAGGATGTACCTCTCTGGTGCTGTTACAGTACATTCTGTACCTGCCATACAGGCTCATTTTCATGCAAATTCTTCCTAGAG >419_419_2_ABHD2-BIRC6_ABHD2_chr15_89745591_ENST00000355100_BIRC6_chr2_32820101_ENST00000421745_length(amino acids)=428AA_BP= MIKMNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMG RVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDITMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVLNHLGALPNIELTSPRMF TYGCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKI ILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ABHD2-BIRC6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ABHD2-BIRC6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ABHD2-BIRC6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C0006826 | Malignant Neoplasms | 1 | CTD_human | |
| Tgene | C0027651 | Neoplasms | 1 | CTD_human | |
| Tgene | C0086692 | Benign Neoplasm | 1 | CTD_human |
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