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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHD2-HOMER2 (FusionGDB2 ID:HG1106TG9455)

Fusion Gene Summary for CHD2-HOMER2

check button Fusion gene summary
Fusion gene informationFusion gene name: CHD2-HOMER2
Fusion gene ID: hg1106tg9455
HgeneTgene
Gene symbol

CHD2

HOMER2

Gene ID

1106

9455

Gene namechromodomain helicase DNA binding protein 2homer scaffold protein 2
SynonymsEEOCACPD|CPD|DFNA68|HOMER-2|VESL-2
Cytomap('CHD2')('HOMER2')

15q26.1

15q25.2

Type of geneprotein-codingprotein-coding
Descriptionchromodomain-helicase-DNA-binding protein 2ATP-dependent helicase CHD2CHD-2homer protein homolog 2cupidinhomer homolog 2homer homolog 3homer scaffolding protein 2homer, neuronal immediate early gene, 2
Modification date2020031320200313
UniProtAcc

O14647

Q9NSB8

Ensembl transtripts involved in fusion geneENST00000394196, ENST00000557381, 
ENST00000420239, ENST00000536619, 
ENST00000554122, 
Fusion gene scores* DoF score22 X 13 X 11=31468 X 6 X 3=144
# samples 238
** MAII scorelog2(23/3146*10)=-3.77381290447131
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHD2 [Title/Abstract] AND HOMER2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHD2(93496803)-HOMER2(83533011), # samples:4
Anticipated loss of major functional domain due to fusion event.CHD2-HOMER2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD2-HOMER2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD2-HOMER2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD2-HOMER2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CHD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across HOMER2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A06U-01ACHD2chr15

93496803

-HOMER2chr15

83533011

-
ChimerDB4BRCATCGA-A8-A06U-01ACHD2chr15

93496803

+HOMER2chr15

83533011

-
ChimerDB4BRCATCGA-A8-A06UCHD2chr15

93496803

+HOMER2chr15

83533011

-


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Fusion Gene ORF analysis for CHD2-HOMER2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000394196ENST00000500334CHD2chr15

93496803

+HOMER2chr15

83533011

-
5CDS-intronENST00000557381ENST00000500334CHD2chr15

93496803

+HOMER2chr15

83533011

-
In-frameENST00000394196ENST00000304231CHD2chr15

93496803

+HOMER2chr15

83533011

-
In-frameENST00000394196ENST00000399166CHD2chr15

93496803

+HOMER2chr15

83533011

-
In-frameENST00000394196ENST00000426485CHD2chr15

93496803

+HOMER2chr15

83533011

-
In-frameENST00000394196ENST00000450735CHD2chr15

93496803

+HOMER2chr15

83533011

-
In-frameENST00000557381ENST00000304231CHD2chr15

93496803

+HOMER2chr15

83533011

-
In-frameENST00000557381ENST00000399166CHD2chr15

93496803

+HOMER2chr15

83533011

-
In-frameENST00000557381ENST00000426485CHD2chr15

93496803

+HOMER2chr15

83533011

-
In-frameENST00000557381ENST00000450735CHD2chr15

93496803

+HOMER2chr15

83533011

-
intron-3CDSENST00000420239ENST00000304231CHD2chr15

93496803

+HOMER2chr15

83533011

-
intron-3CDSENST00000420239ENST00000399166CHD2chr15

93496803

+HOMER2chr15

83533011

-
intron-3CDSENST00000420239ENST00000426485CHD2chr15

93496803

+HOMER2chr15

83533011

-
intron-3CDSENST00000420239ENST00000450735CHD2chr15

93496803

+HOMER2chr15

83533011

-
intron-3CDSENST00000536619ENST00000304231CHD2chr15

93496803

+HOMER2chr15

83533011

-
intron-3CDSENST00000536619ENST00000399166CHD2chr15

93496803

+HOMER2chr15

83533011

-
intron-3CDSENST00000536619ENST00000426485CHD2chr15

93496803

+HOMER2chr15

83533011

-
intron-3CDSENST00000536619ENST00000450735CHD2chr15

93496803

+HOMER2chr15

83533011

-
intron-3CDSENST00000554122ENST00000304231CHD2chr15

93496803

+HOMER2chr15

83533011

-
intron-3CDSENST00000554122ENST00000399166CHD2chr15

93496803

+HOMER2chr15

83533011

-
intron-3CDSENST00000554122ENST00000426485CHD2chr15

93496803

+HOMER2chr15

83533011

-
intron-3CDSENST00000554122ENST00000450735CHD2chr15

93496803

+HOMER2chr15

83533011

-
intron-intronENST00000420239ENST00000500334CHD2chr15

93496803

+HOMER2chr15

83533011

-
intron-intronENST00000536619ENST00000500334CHD2chr15

93496803

+HOMER2chr15

83533011

-
intron-intronENST00000554122ENST00000500334CHD2chr15

93496803

+HOMER2chr15

83533011

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394196CHD2chr1593496803+ENST00000450735HOMER2chr1583533011-4257278710683524818
ENST00000394196CHD2chr1593496803+ENST00000304231HOMER2chr1583533011-4290278710683557829
ENST00000394196CHD2chr1593496803+ENST00000399166HOMER2chr1583533011-4089278710683359763
ENST00000394196CHD2chr1593496803+ENST00000426485HOMER2chr1583533011-4122278710683392774
ENST00000557381CHD2chr1593496803+ENST00000450735HOMER2chr1583533011-389624267073163818
ENST00000557381CHD2chr1593496803+ENST00000304231HOMER2chr1583533011-392924267073196829
ENST00000557381CHD2chr1593496803+ENST00000399166HOMER2chr1583533011-372824267072998763
ENST00000557381CHD2chr1593496803+ENST00000426485HOMER2chr1583533011-376124267073031774

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394196ENST00000450735CHD2chr1593496803+HOMER2chr1583533011-0.0025033940.99749655
ENST00000394196ENST00000304231CHD2chr1593496803+HOMER2chr1583533011-0.002278960.997721
ENST00000394196ENST00000399166CHD2chr1593496803+HOMER2chr1583533011-0.0025945510.99740547
ENST00000394196ENST00000426485CHD2chr1593496803+HOMER2chr1583533011-0.0022554850.99774456
ENST00000557381ENST00000450735CHD2chr1593496803+HOMER2chr1583533011-0.0035208480.9964792
ENST00000557381ENST00000304231CHD2chr1593496803+HOMER2chr1583533011-0.0031847550.99681526
ENST00000557381ENST00000399166CHD2chr1593496803+HOMER2chr1583533011-0.0035727970.99642724
ENST00000557381ENST00000426485CHD2chr1593496803+HOMER2chr1583533011-0.0030964060.9969036

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Fusion Genomic Features for CHD2-HOMER2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CHD2-HOMER2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:93496803/chr15:83533011)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHD2

O14647

HOMER2

Q9NSB8

FUNCTION: DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). {ECO:0000250}.FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459). Required for normal hearing (PubMed:25816005). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000269|PubMed:18218901, ECO:0000269|PubMed:25816005, ECO:0000269|PubMed:9808459}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHD2chr15:93496803chr15:83533011ENST00000394196+1439121_1395731829.0Compositional biasNote=Ser-rich
HgeneCHD2chr15:93496803chr15:83533011ENST00000394196+143913_745731829.0Compositional biasNote=Ser-rich
HgeneCHD2chr15:93496803chr15:83533011ENST00000557381+1438121_1395731740.0Compositional biasNote=Ser-rich
HgeneCHD2chr15:93496803chr15:83533011ENST00000557381+143813_745731740.0Compositional biasNote=Ser-rich
HgeneCHD2chr15:93496803chr15:83533011ENST00000394196+1439261_3535731829.0DomainChromo 1
HgeneCHD2chr15:93496803chr15:83533011ENST00000394196+1439378_4565731829.0DomainChromo 2
HgeneCHD2chr15:93496803chr15:83533011ENST00000557381+1438261_3535731740.0DomainChromo 1
HgeneCHD2chr15:93496803chr15:83533011ENST00000557381+1438378_4565731740.0DomainChromo 2
HgeneCHD2chr15:93496803chr15:83533011ENST00000394196+1439509_5165731829.0Nucleotide bindingATP
HgeneCHD2chr15:93496803chr15:83533011ENST00000557381+1438509_5165731740.0Nucleotide bindingATP
TgeneHOMER2chr15:93496803chr15:83533011ENST0000030423129160_32998355.0Coiled coilOntology_term=ECO:0000255
TgeneHOMER2chr15:93496803chr15:83533011ENST0000045073529160_32998344.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHD2chr15:93496803chr15:83533011ENST00000394196+1439966_10665731829.0Compositional biasNote=Glu-rich
HgeneCHD2chr15:93496803chr15:83533011ENST00000420239+113121_1390502.0Compositional biasNote=Ser-rich
HgeneCHD2chr15:93496803chr15:83533011ENST00000420239+11313_740502.0Compositional biasNote=Ser-rich
HgeneCHD2chr15:93496803chr15:83533011ENST00000420239+113966_10660502.0Compositional biasNote=Glu-rich
HgeneCHD2chr15:93496803chr15:83533011ENST00000557381+1438966_10665731740.0Compositional biasNote=Glu-rich
HgeneCHD2chr15:93496803chr15:83533011ENST00000394196+1439496_6665731829.0DomainHelicase ATP-binding
HgeneCHD2chr15:93496803chr15:83533011ENST00000394196+1439795_9465731829.0DomainHelicase C-terminal
HgeneCHD2chr15:93496803chr15:83533011ENST00000420239+113261_3530502.0DomainChromo 1
HgeneCHD2chr15:93496803chr15:83533011ENST00000420239+113378_4560502.0DomainChromo 2
HgeneCHD2chr15:93496803chr15:83533011ENST00000420239+113496_6660502.0DomainHelicase ATP-binding
HgeneCHD2chr15:93496803chr15:83533011ENST00000420239+113795_9460502.0DomainHelicase C-terminal
HgeneCHD2chr15:93496803chr15:83533011ENST00000557381+1438496_6665731740.0DomainHelicase ATP-binding
HgeneCHD2chr15:93496803chr15:83533011ENST00000557381+1438795_9465731740.0DomainHelicase C-terminal
HgeneCHD2chr15:93496803chr15:83533011ENST00000394196+1439617_6205731829.0MotifNote=DEAH box
HgeneCHD2chr15:93496803chr15:83533011ENST00000420239+113617_6200502.0MotifNote=DEAH box
HgeneCHD2chr15:93496803chr15:83533011ENST00000557381+1438617_6205731740.0MotifNote=DEAH box
HgeneCHD2chr15:93496803chr15:83533011ENST00000420239+113509_5160502.0Nucleotide bindingATP
TgeneHOMER2chr15:93496803chr15:83533011ENST000003042312992_12298355.0Coiled coilOntology_term=ECO:0000255
TgeneHOMER2chr15:93496803chr15:83533011ENST000004507352992_12298344.0Coiled coilOntology_term=ECO:0000255
TgeneHOMER2chr15:93496803chr15:83533011ENST00000304231291_11098355.0DomainWH1
TgeneHOMER2chr15:93496803chr15:83533011ENST00000450735291_11098344.0DomainWH1


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Fusion Gene Sequence for CHD2-HOMER2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16301_16301_1_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000394196_HOMER2_chr15_83533011_ENST00000304231_length(transcript)=4290nt_BP=2787nt
TAAAGAAGGAAAAACTTGAATTTATATTATGAAATTAAGGTTTTACTTTTATTTAGCAATCATTTCACCCATTGGGGGATTAATTTTTAA
AAAGATTAGTACTTAGCTGAGCTTTAGATTCTCTAAGAATTATCCCTTTTTCAAAATGGCTTGATAAAACACCACTTCCTGTCCAGGGAG
GAAGTTATTTTAGCTCAAGGACTGAAATATTTAGCAGATCTTTAGACAAAAGGAACAAATTACATTTCTCTCTGGCTTAAAAAGGGTGCT
TGAGCCAGAGGGGGTTAAGAAGCCCTCCCCCCTCCCCCTGTTGGGGTGGTCTGGAGGGGCAGGGAGGTGTGGGGGTGGGGGTCCTTAGGC
TCCCTGGGATGGAGGATCTGTCTCTCTCTCTCTCTCTCCTTTTTTTTTTTTTGGTGGAGATGAAGGGGTGGGTCTATGGTACATCACCTG
AGTTGTGGGGTAAATGTAGAGAGTGTCAATCAAAGGCAGAGCTCTCAGAGCTGGGAAGGAGGCTCTAGATGGCGGCTGTGCCTTAGAGAG
AGCGCGCTCTGCTCCCTGCCTTTGCCTCACTTTACGCAACTTTCCCTAACTTTCGGGCAGCCTCAGGGGGCCCCCGTAGCCCCCTGCCTT
TCCTAGGGACTTACTGGGGTCGATTCGAACCTTTTTTTGGGAGAAAAGCAGCTTTTAGGAGCTTTCTTTTCGTGCCTTGTTGGAAAGAAG
CAGCCGTACTGAGAGCCCAGGTCGTTGTTTTTTCCAGCTTAGAAGCCATGGCGCACCTCCATTTTTGTGCGCTCTCCTAATGAGGTTTTT
TTTCTTTCGGACCTGTTTTAGTATTAATTATTGCTTTATTTTTTTGACCAGTTAACATATTTGAGGGTTATTTTATTTATTTTTCGTTTT
TTAACGGAGGATTTTGCCTTTATTTTTAATTATTTGGGATCTGATATTTTTCTACTAGTAGATAGGACTCTTGGTTTGGACATACTACAT
GGATCAGTAAATACCTGGGCACAGGACTTCAAAGCAAACACAGATTCCCCCTCCCCCTTAATATTTAAGAATTAAAAGATGATGAGAAAT
AAGGACAAAAGCCAAGAGGAGGACAGTTCGCTACACAGCAATGCATCGAGTCACTCAGCCTCTGAAGAAGCTTCGGGTTCAGACTCAGGC
AGTCAGTCGGAAAGTGAGCAGGGAAGTGATCCAGGAAGTGGACATGGCAGCGAGTCGAACAGCAGCTCTGAATCTTCTGAGAGTCAGTCG
GAATCTGAGAGCGAATCAGCAGGTTCCAAATCCCAGCCAGTCCTCCCAGAAGCCAAAGAGAAGCCAGCCTCTAAGAAGGAACGGATAGCT
GATGTGAAGAAGATGTGGGAAGAATATCCTGATGTTTATGGGGTCAGGCGGTCAAACCGAAGCAGACAAGAACCATCGCGATTTAATATT
AAGGAAGAGGCAAGTAGCGGGTCTGAGAGTGGGAGCCCAAAAAGAAGAGGCCAGAGGCAGCTGAAAAAACAAGAAAAATGGAAACAGGAA
CCCTCAGAAGATGAACAGGAACAAGGCACCAGTGCAGAGAGTGAGCCAGAACAAAAAAAAGTAAAAGCCAGAAGACCTGTCCCCAGAAGA
ACAGTGCCCAAACCTCGTGTTAAAAAGCAGCCGAAGACTCAGCGTGGAAAGAGAAAAAAGCAAGATTCTTCTGATGAGGATGATGATGAT
GACGAAGCTCCCAAAAGGCAGACTCGTCGAAGAGCGGCTAAAAACGTTAGTTACAAAGAAGATGATGACTTTGAGACTGACTCAGATGAT
CTCATTGAAATGACTGGAGAAGGAGTTGATGAACAGCAAGATAATAGTGAAACTATTGAAAAGGTCTTAGATTCAAGACTGGGAAAGAAA
GGAGCCACTGGAGCATCTACTACTGTATATGCGATTGAAGCTAATGGCGACCCTAGTGGTGACTTTGACACTGAAAAGGATGAAGGTGAA
ATCCAGTACCTCATCAAGTGGAAGGGTTGGTCTTACATCCACAGCACATGGGAGAGTGAAGAATCCTTACAGCAACAGAAAGTGAAGGGC
CTAAAAAAACTAGAGAACTTCAAGAAAAAAGAGGACGAAATCAAACAATGGTTAGGGAAAGTTTCTCCTGAAGATGTAGAATATTTCAAT
TGCCAACAGGAGCTGGCTTCAGAGTTGAATAAACAGTATCAGATAGTAGAAAGAGTAATAGCTGTGAAGACAAGTAAATCTACATTGGGT
CAAACAGATTTTCCAGCTCATAGTCGGAAGCCGGCACCCTCAAATGAGCCCGAATATCTATGTAAATGGATGGGACTCCCCTATTCAGAG
TGTAGCTGGGAAGATGAAGCCCTCATTGGAAAGAAATTCCAGAATTGCATTGACAGCTTCCACAGTAGGAACAACTCAAAAACCATCCCA
ACAAGAGAATGCAAGGCCCTGAAGCAGAGACCACGATTTGTAGCTTTAAAGAAACAACCTGCATATTTAGGAGGGGAGAATCTGGAACTT
CGAGATTATCAGCTAGAAGGTCTAAACTGGCTAGCTCATTCCTGGTGCAAAAATAATAGTGTAATCCTTGCTGATGAAATGGGCCTAGGA
AAGACCATCCAGACCATATCATTCCTCTCCTACCTGTTCCACCAACACCAGCTGTATGGCCCCTTTCTTATAGTCGTCCCTTTATCCACC
CTCACCTCATGGCAGAGAGAGTTTGAAATCTGGGCACCAGAGATTAACGTAGTGGTTTACATAGGTGACCTGATGAGCAGAAATACGTTT
GCAGAGAAATTCCAGGAGGTGAAAGAAGCTGCCAAGATAGCCAAAGACAAGACGCAGGAGAAAATCGAGACCTCAAGTAATCATTCCCAA
GAATCTGGGCGTGAAACCCCATCTTCTACTCAGGCATCCAGTGTCAACGGGACGGACGATGAAAAGGCCTCTCACGCCGGTCCAGCCAAC
ACACACCTGAAGTCTGAGAATGACAAGCTGAAGATTGCCTTGACGCAGAGCGCAGCCAACGTGAAGAAGTGGGAGATCGAGCTGCAGACC
CTTCGGGAGAGCAATGCACGGCTGACCACAGCACTGCAGGAGTCGGCAGCCAGTGTGGAGCAGTGGAAGAGGCAGTTCTCCATCTGCCGT
GATGAGAATGACCGGCTCCGCAACAAGATTGATGAGCTGGAAGAACAATGCAGTGAGATCAACAGAGAGAAGGAGAAGAACACGCAGCTG
AAGAGGAGGATCGAGGAGCTGGAGGCAGAGCTCCGAGAAAAGGAGACAGAGCTGAAAGATCTCCGAAAACAAAGTGAAATCATACCTCAG
CTCATGTCAGAGTGCGAATATGTCTCTGAGAAGCTAGAGGCGGCAGAGAGAGACAATCAAAACCTGGAAGACAAAGTGCGTTCCTTAAAG
ACAGACATTGAGGAGAGCAAATACCGACAGCGCCACCTGAAGGTGGAGTTGAAGAGCTTCCTGGAGGTGCTGGACGGGAAGATTGACGAC
CTGCATGACTTCCGCCGAGGGCTCTCCAAGCTGGGCACCGATAACTAGGGCTGGCCGAGGCCCAGGCCCCGCCCGTGAGTCCCAAGCGTG
TGTGCGAGACCAGATAGCTCTAGGACGTTCTTCTGTGTGCATTGCTTCTGTAAATGCAGGCGCAGTTTGTCGTGTTTCCAAACCAGTTGT
GCCGTCCACTCACTCCTTTTCAGAATAGAAATCTCCTCTCGCTTCTCTGGCCTTGTGAGGTTGTGGACAACTGGAAGATTCTGACTCAGG
AATCCAGAACTAGGTCTACCTTCAACATTTATGCAGTCAGGGCAGGGATGTTTATATCTTTCATAAGGGCTGTTGCAACCATATGAACTG
AAAAAACACGCATTTTGTAATCCAAATATTGATATTCTTTACACCAAGCCATCAGGCTCCTTTTATCAAATAGCATTCAGAGTATTTGAA
TGTCCACCAGACACCAGCCCCGGGGGGCACAGAGAGAACAACATTCCTCTCTGTCAACATCGAGAGGCTTTAAAACAACTGTTTAGTGGA
AACTTTCTGAGAGATGGAAAACAAGCTTCTGGTGGGTGCATTTTCTGGCCCGGAGTTGCCTGCATCCACGCTACTGCCCCCTGCCCCCCG
CCCCCCCAGTTTGTACGGTTGCAACAGTGTTCCTTTTCTTGGTTTTAATTTCTGAGCAGATGATTGTGCTGTGGGAACAGCACACAGTGA
GGGTGCCTAGCACAATGTCTGGCACAAAGTAGGTGCTTAATAAATATTTGTTCAATTAAA

>16301_16301_1_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000394196_HOMER2_chr15_83533011_ENST00000304231_length(amino acids)=829AA_BP=573
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHA
GPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEK
NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDG
KIDDLHDFRRGLSKLGTDN

--------------------------------------------------------------
>16301_16301_2_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000394196_HOMER2_chr15_83533011_ENST00000399166_length(transcript)=4089nt_BP=2787nt
TAAAGAAGGAAAAACTTGAATTTATATTATGAAATTAAGGTTTTACTTTTATTTAGCAATCATTTCACCCATTGGGGGATTAATTTTTAA
AAAGATTAGTACTTAGCTGAGCTTTAGATTCTCTAAGAATTATCCCTTTTTCAAAATGGCTTGATAAAACACCACTTCCTGTCCAGGGAG
GAAGTTATTTTAGCTCAAGGACTGAAATATTTAGCAGATCTTTAGACAAAAGGAACAAATTACATTTCTCTCTGGCTTAAAAAGGGTGCT
TGAGCCAGAGGGGGTTAAGAAGCCCTCCCCCCTCCCCCTGTTGGGGTGGTCTGGAGGGGCAGGGAGGTGTGGGGGTGGGGGTCCTTAGGC
TCCCTGGGATGGAGGATCTGTCTCTCTCTCTCTCTCTCCTTTTTTTTTTTTTGGTGGAGATGAAGGGGTGGGTCTATGGTACATCACCTG
AGTTGTGGGGTAAATGTAGAGAGTGTCAATCAAAGGCAGAGCTCTCAGAGCTGGGAAGGAGGCTCTAGATGGCGGCTGTGCCTTAGAGAG
AGCGCGCTCTGCTCCCTGCCTTTGCCTCACTTTACGCAACTTTCCCTAACTTTCGGGCAGCCTCAGGGGGCCCCCGTAGCCCCCTGCCTT
TCCTAGGGACTTACTGGGGTCGATTCGAACCTTTTTTTGGGAGAAAAGCAGCTTTTAGGAGCTTTCTTTTCGTGCCTTGTTGGAAAGAAG
CAGCCGTACTGAGAGCCCAGGTCGTTGTTTTTTCCAGCTTAGAAGCCATGGCGCACCTCCATTTTTGTGCGCTCTCCTAATGAGGTTTTT
TTTCTTTCGGACCTGTTTTAGTATTAATTATTGCTTTATTTTTTTGACCAGTTAACATATTTGAGGGTTATTTTATTTATTTTTCGTTTT
TTAACGGAGGATTTTGCCTTTATTTTTAATTATTTGGGATCTGATATTTTTCTACTAGTAGATAGGACTCTTGGTTTGGACATACTACAT
GGATCAGTAAATACCTGGGCACAGGACTTCAAAGCAAACACAGATTCCCCCTCCCCCTTAATATTTAAGAATTAAAAGATGATGAGAAAT
AAGGACAAAAGCCAAGAGGAGGACAGTTCGCTACACAGCAATGCATCGAGTCACTCAGCCTCTGAAGAAGCTTCGGGTTCAGACTCAGGC
AGTCAGTCGGAAAGTGAGCAGGGAAGTGATCCAGGAAGTGGACATGGCAGCGAGTCGAACAGCAGCTCTGAATCTTCTGAGAGTCAGTCG
GAATCTGAGAGCGAATCAGCAGGTTCCAAATCCCAGCCAGTCCTCCCAGAAGCCAAAGAGAAGCCAGCCTCTAAGAAGGAACGGATAGCT
GATGTGAAGAAGATGTGGGAAGAATATCCTGATGTTTATGGGGTCAGGCGGTCAAACCGAAGCAGACAAGAACCATCGCGATTTAATATT
AAGGAAGAGGCAAGTAGCGGGTCTGAGAGTGGGAGCCCAAAAAGAAGAGGCCAGAGGCAGCTGAAAAAACAAGAAAAATGGAAACAGGAA
CCCTCAGAAGATGAACAGGAACAAGGCACCAGTGCAGAGAGTGAGCCAGAACAAAAAAAAGTAAAAGCCAGAAGACCTGTCCCCAGAAGA
ACAGTGCCCAAACCTCGTGTTAAAAAGCAGCCGAAGACTCAGCGTGGAAAGAGAAAAAAGCAAGATTCTTCTGATGAGGATGATGATGAT
GACGAAGCTCCCAAAAGGCAGACTCGTCGAAGAGCGGCTAAAAACGTTAGTTACAAAGAAGATGATGACTTTGAGACTGACTCAGATGAT
CTCATTGAAATGACTGGAGAAGGAGTTGATGAACAGCAAGATAATAGTGAAACTATTGAAAAGGTCTTAGATTCAAGACTGGGAAAGAAA
GGAGCCACTGGAGCATCTACTACTGTATATGCGATTGAAGCTAATGGCGACCCTAGTGGTGACTTTGACACTGAAAAGGATGAAGGTGAA
ATCCAGTACCTCATCAAGTGGAAGGGTTGGTCTTACATCCACAGCACATGGGAGAGTGAAGAATCCTTACAGCAACAGAAAGTGAAGGGC
CTAAAAAAACTAGAGAACTTCAAGAAAAAAGAGGACGAAATCAAACAATGGTTAGGGAAAGTTTCTCCTGAAGATGTAGAATATTTCAAT
TGCCAACAGGAGCTGGCTTCAGAGTTGAATAAACAGTATCAGATAGTAGAAAGAGTAATAGCTGTGAAGACAAGTAAATCTACATTGGGT
CAAACAGATTTTCCAGCTCATAGTCGGAAGCCGGCACCCTCAAATGAGCCCGAATATCTATGTAAATGGATGGGACTCCCCTATTCAGAG
TGTAGCTGGGAAGATGAAGCCCTCATTGGAAAGAAATTCCAGAATTGCATTGACAGCTTCCACAGTAGGAACAACTCAAAAACCATCCCA
ACAAGAGAATGCAAGGCCCTGAAGCAGAGACCACGATTTGTAGCTTTAAAGAAACAACCTGCATATTTAGGAGGGGAGAATCTGGAACTT
CGAGATTATCAGCTAGAAGGTCTAAACTGGCTAGCTCATTCCTGGTGCAAAAATAATAGTGTAATCCTTGCTGATGAAATGGGCCTAGGA
AAGACCATCCAGACCATATCATTCCTCTCCTACCTGTTCCACCAACACCAGCTGTATGGCCCCTTTCTTATAGTCGTCCCTTTATCCACC
CTCACCTCATGGCAGAGAGAGTTTGAAATCTGGGCACCAGAGATTAACGTAGTGGTTTACATAGGTGACCTGATGAGCAGAAATACGTTT
GCAGAGAAATTCCAGGAGGTGAAAGAAGCTGCCAAGATAGCCAAAGACAAGACGCAGGAGAAAATCGAGACCTCAAGTAATCATTCCCAA
GCATCCAGTGTCAACGGGACGGACGATGAAAAGGCCTCTCACGCCGGTCCAGCCAACACACACCTGAAGTCTGAGAATGACAAGCTGAAG
ATTGCCTTGACGCAGAGCGCAGCCAACGTGAAGAATGAGATCAACAGAGAGAAGGAGAAGAACACGCAGCTGAAGAGGAGGATCGAGGAG
CTGGAGGCAGAGCTCCGAGAAAAGGAGACAGAGCTGAAAGATCTCCGAAAACAAAGTGAAATCATACCTCAGCTCATGTCAGAGTGCGAA
TATGTCTCTGAGAAGCTAGAGGCGGCAGAGAGAGACAATCAAAACCTGGAAGACAAAGTGCGTTCCTTAAAGACAGACATTGAGGAGAGC
AAATACCGACAGCGCCACCTGAAGGTGGAGTTGAAGAGCTTCCTGGAGGTGCTGGACGGGAAGATTGACGACCTGCATGACTTCCGCCGA
GGGCTCTCCAAGCTGGGCACCGATAACTAGGGCTGGCCGAGGCCCAGGCCCCGCCCGTGAGTCCCAAGCGTGTGTGCGAGACCAGATAGC
TCTAGGACGTTCTTCTGTGTGCATTGCTTCTGTAAATGCAGGCGCAGTTTGTCGTGTTTCCAAACCAGTTGTGCCGTCCACTCACTCCTT
TTCAGAATAGAAATCTCCTCTCGCTTCTCTGGCCTTGTGAGGTTGTGGACAACTGGAAGATTCTGACTCAGGAATCCAGAACTAGGTCTA
CCTTCAACATTTATGCAGTCAGGGCAGGGATGTTTATATCTTTCATAAGGGCTGTTGCAACCATATGAACTGAAAAAACACGCATTTTGT
AATCCAAATATTGATATTCTTTACACCAAGCCATCAGGCTCCTTTTATCAAATAGCATTCAGAGTATTTGAATGTCCACCAGACACCAGC
CCCGGGGGGCACAGAGAGAACAACATTCCTCTCTGTCAACATCGAGAGGCTTTAAAACAACTGTTTAGTGGAAACTTTCTGAGAGATGGA
AAACAAGCTTCTGGTGGGTGCATTTTCTGGCCCGGAGTTGCCTGCATCCACGCTACTGCCCCCTGCCCCCCGCCCCCCCAGTTTGTACGG
TTGCAACAGTGTTCCTTTTCTTGGTTTTAATTTCTGAGCAGATGATTGTGCTGTGGGAACAGCACACAGTGAGGGTGCCTAGCACAATGT
CTGGCACAAAGTAGGTGCTTAATAAATATTTGTTCAATT

>16301_16301_2_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000394196_HOMER2_chr15_83533011_ENST00000399166_length(amino acids)=763AA_BP=573
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSEN
DKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD
IEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN

--------------------------------------------------------------
>16301_16301_3_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000394196_HOMER2_chr15_83533011_ENST00000426485_length(transcript)=4122nt_BP=2787nt
TAAAGAAGGAAAAACTTGAATTTATATTATGAAATTAAGGTTTTACTTTTATTTAGCAATCATTTCACCCATTGGGGGATTAATTTTTAA
AAAGATTAGTACTTAGCTGAGCTTTAGATTCTCTAAGAATTATCCCTTTTTCAAAATGGCTTGATAAAACACCACTTCCTGTCCAGGGAG
GAAGTTATTTTAGCTCAAGGACTGAAATATTTAGCAGATCTTTAGACAAAAGGAACAAATTACATTTCTCTCTGGCTTAAAAAGGGTGCT
TGAGCCAGAGGGGGTTAAGAAGCCCTCCCCCCTCCCCCTGTTGGGGTGGTCTGGAGGGGCAGGGAGGTGTGGGGGTGGGGGTCCTTAGGC
TCCCTGGGATGGAGGATCTGTCTCTCTCTCTCTCTCTCCTTTTTTTTTTTTTGGTGGAGATGAAGGGGTGGGTCTATGGTACATCACCTG
AGTTGTGGGGTAAATGTAGAGAGTGTCAATCAAAGGCAGAGCTCTCAGAGCTGGGAAGGAGGCTCTAGATGGCGGCTGTGCCTTAGAGAG
AGCGCGCTCTGCTCCCTGCCTTTGCCTCACTTTACGCAACTTTCCCTAACTTTCGGGCAGCCTCAGGGGGCCCCCGTAGCCCCCTGCCTT
TCCTAGGGACTTACTGGGGTCGATTCGAACCTTTTTTTGGGAGAAAAGCAGCTTTTAGGAGCTTTCTTTTCGTGCCTTGTTGGAAAGAAG
CAGCCGTACTGAGAGCCCAGGTCGTTGTTTTTTCCAGCTTAGAAGCCATGGCGCACCTCCATTTTTGTGCGCTCTCCTAATGAGGTTTTT
TTTCTTTCGGACCTGTTTTAGTATTAATTATTGCTTTATTTTTTTGACCAGTTAACATATTTGAGGGTTATTTTATTTATTTTTCGTTTT
TTAACGGAGGATTTTGCCTTTATTTTTAATTATTTGGGATCTGATATTTTTCTACTAGTAGATAGGACTCTTGGTTTGGACATACTACAT
GGATCAGTAAATACCTGGGCACAGGACTTCAAAGCAAACACAGATTCCCCCTCCCCCTTAATATTTAAGAATTAAAAGATGATGAGAAAT
AAGGACAAAAGCCAAGAGGAGGACAGTTCGCTACACAGCAATGCATCGAGTCACTCAGCCTCTGAAGAAGCTTCGGGTTCAGACTCAGGC
AGTCAGTCGGAAAGTGAGCAGGGAAGTGATCCAGGAAGTGGACATGGCAGCGAGTCGAACAGCAGCTCTGAATCTTCTGAGAGTCAGTCG
GAATCTGAGAGCGAATCAGCAGGTTCCAAATCCCAGCCAGTCCTCCCAGAAGCCAAAGAGAAGCCAGCCTCTAAGAAGGAACGGATAGCT
GATGTGAAGAAGATGTGGGAAGAATATCCTGATGTTTATGGGGTCAGGCGGTCAAACCGAAGCAGACAAGAACCATCGCGATTTAATATT
AAGGAAGAGGCAAGTAGCGGGTCTGAGAGTGGGAGCCCAAAAAGAAGAGGCCAGAGGCAGCTGAAAAAACAAGAAAAATGGAAACAGGAA
CCCTCAGAAGATGAACAGGAACAAGGCACCAGTGCAGAGAGTGAGCCAGAACAAAAAAAAGTAAAAGCCAGAAGACCTGTCCCCAGAAGA
ACAGTGCCCAAACCTCGTGTTAAAAAGCAGCCGAAGACTCAGCGTGGAAAGAGAAAAAAGCAAGATTCTTCTGATGAGGATGATGATGAT
GACGAAGCTCCCAAAAGGCAGACTCGTCGAAGAGCGGCTAAAAACGTTAGTTACAAAGAAGATGATGACTTTGAGACTGACTCAGATGAT
CTCATTGAAATGACTGGAGAAGGAGTTGATGAACAGCAAGATAATAGTGAAACTATTGAAAAGGTCTTAGATTCAAGACTGGGAAAGAAA
GGAGCCACTGGAGCATCTACTACTGTATATGCGATTGAAGCTAATGGCGACCCTAGTGGTGACTTTGACACTGAAAAGGATGAAGGTGAA
ATCCAGTACCTCATCAAGTGGAAGGGTTGGTCTTACATCCACAGCACATGGGAGAGTGAAGAATCCTTACAGCAACAGAAAGTGAAGGGC
CTAAAAAAACTAGAGAACTTCAAGAAAAAAGAGGACGAAATCAAACAATGGTTAGGGAAAGTTTCTCCTGAAGATGTAGAATATTTCAAT
TGCCAACAGGAGCTGGCTTCAGAGTTGAATAAACAGTATCAGATAGTAGAAAGAGTAATAGCTGTGAAGACAAGTAAATCTACATTGGGT
CAAACAGATTTTCCAGCTCATAGTCGGAAGCCGGCACCCTCAAATGAGCCCGAATATCTATGTAAATGGATGGGACTCCCCTATTCAGAG
TGTAGCTGGGAAGATGAAGCCCTCATTGGAAAGAAATTCCAGAATTGCATTGACAGCTTCCACAGTAGGAACAACTCAAAAACCATCCCA
ACAAGAGAATGCAAGGCCCTGAAGCAGAGACCACGATTTGTAGCTTTAAAGAAACAACCTGCATATTTAGGAGGGGAGAATCTGGAACTT
CGAGATTATCAGCTAGAAGGTCTAAACTGGCTAGCTCATTCCTGGTGCAAAAATAATAGTGTAATCCTTGCTGATGAAATGGGCCTAGGA
AAGACCATCCAGACCATATCATTCCTCTCCTACCTGTTCCACCAACACCAGCTGTATGGCCCCTTTCTTATAGTCGTCCCTTTATCCACC
CTCACCTCATGGCAGAGAGAGTTTGAAATCTGGGCACCAGAGATTAACGTAGTGGTTTACATAGGTGACCTGATGAGCAGAAATACGTTT
GCAGAGAAATTCCAGGAGGTGAAAGAAGCTGCCAAGATAGCCAAAGACAAGACGCAGGAGAAAATCGAGACCTCAAGTAATCATTCCCAA
GAATCTGGGCGTGAAACCCCATCTTCTACTCAGGCATCCAGTGTCAACGGGACGGACGATGAAAAGGCCTCTCACGCCGGTCCAGCCAAC
ACACACCTGAAGTCTGAGAATGACAAGCTGAAGATTGCCTTGACGCAGAGCGCAGCCAACGTGAAGAATGAGATCAACAGAGAGAAGGAG
AAGAACACGCAGCTGAAGAGGAGGATCGAGGAGCTGGAGGCAGAGCTCCGAGAAAAGGAGACAGAGCTGAAAGATCTCCGAAAACAAAGT
GAAATCATACCTCAGCTCATGTCAGAGTGCGAATATGTCTCTGAGAAGCTAGAGGCGGCAGAGAGAGACAATCAAAACCTGGAAGACAAA
GTGCGTTCCTTAAAGACAGACATTGAGGAGAGCAAATACCGACAGCGCCACCTGAAGGTGGAGTTGAAGAGCTTCCTGGAGGTGCTGGAC
GGGAAGATTGACGACCTGCATGACTTCCGCCGAGGGCTCTCCAAGCTGGGCACCGATAACTAGGGCTGGCCGAGGCCCAGGCCCCGCCCG
TGAGTCCCAAGCGTGTGTGCGAGACCAGATAGCTCTAGGACGTTCTTCTGTGTGCATTGCTTCTGTAAATGCAGGCGCAGTTTGTCGTGT
TTCCAAACCAGTTGTGCCGTCCACTCACTCCTTTTCAGAATAGAAATCTCCTCTCGCTTCTCTGGCCTTGTGAGGTTGTGGACAACTGGA
AGATTCTGACTCAGGAATCCAGAACTAGGTCTACCTTCAACATTTATGCAGTCAGGGCAGGGATGTTTATATCTTTCATAAGGGCTGTTG
CAACCATATGAACTGAAAAAACACGCATTTTGTAATCCAAATATTGATATTCTTTACACCAAGCCATCAGGCTCCTTTTATCAAATAGCA
TTCAGAGTATTTGAATGTCCACCAGACACCAGCCCCGGGGGGCACAGAGAGAACAACATTCCTCTCTGTCAACATCGAGAGGCTTTAAAA
CAACTGTTTAGTGGAAACTTTCTGAGAGATGGAAAACAAGCTTCTGGTGGGTGCATTTTCTGGCCCGGAGTTGCCTGCATCCACGCTACT
GCCCCCTGCCCCCCGCCCCCCCAGTTTGTACGGTTGCAACAGTGTTCCTTTTCTTGGTTTTAATTTCTGAGCAGATGATTGTGCTGTGGG
AACAGCACACAGTGAGGGTGCCTAGCACAATGTCTGGCACAAAGTAGGTGCTTAATAAATATTTGTTCAATT

>16301_16301_3_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000394196_HOMER2_chr15_83533011_ENST00000426485_length(amino acids)=774AA_BP=573
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHA
GPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN
LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN

--------------------------------------------------------------
>16301_16301_4_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000394196_HOMER2_chr15_83533011_ENST00000450735_length(transcript)=4257nt_BP=2787nt
TAAAGAAGGAAAAACTTGAATTTATATTATGAAATTAAGGTTTTACTTTTATTTAGCAATCATTTCACCCATTGGGGGATTAATTTTTAA
AAAGATTAGTACTTAGCTGAGCTTTAGATTCTCTAAGAATTATCCCTTTTTCAAAATGGCTTGATAAAACACCACTTCCTGTCCAGGGAG
GAAGTTATTTTAGCTCAAGGACTGAAATATTTAGCAGATCTTTAGACAAAAGGAACAAATTACATTTCTCTCTGGCTTAAAAAGGGTGCT
TGAGCCAGAGGGGGTTAAGAAGCCCTCCCCCCTCCCCCTGTTGGGGTGGTCTGGAGGGGCAGGGAGGTGTGGGGGTGGGGGTCCTTAGGC
TCCCTGGGATGGAGGATCTGTCTCTCTCTCTCTCTCTCCTTTTTTTTTTTTTGGTGGAGATGAAGGGGTGGGTCTATGGTACATCACCTG
AGTTGTGGGGTAAATGTAGAGAGTGTCAATCAAAGGCAGAGCTCTCAGAGCTGGGAAGGAGGCTCTAGATGGCGGCTGTGCCTTAGAGAG
AGCGCGCTCTGCTCCCTGCCTTTGCCTCACTTTACGCAACTTTCCCTAACTTTCGGGCAGCCTCAGGGGGCCCCCGTAGCCCCCTGCCTT
TCCTAGGGACTTACTGGGGTCGATTCGAACCTTTTTTTGGGAGAAAAGCAGCTTTTAGGAGCTTTCTTTTCGTGCCTTGTTGGAAAGAAG
CAGCCGTACTGAGAGCCCAGGTCGTTGTTTTTTCCAGCTTAGAAGCCATGGCGCACCTCCATTTTTGTGCGCTCTCCTAATGAGGTTTTT
TTTCTTTCGGACCTGTTTTAGTATTAATTATTGCTTTATTTTTTTGACCAGTTAACATATTTGAGGGTTATTTTATTTATTTTTCGTTTT
TTAACGGAGGATTTTGCCTTTATTTTTAATTATTTGGGATCTGATATTTTTCTACTAGTAGATAGGACTCTTGGTTTGGACATACTACAT
GGATCAGTAAATACCTGGGCACAGGACTTCAAAGCAAACACAGATTCCCCCTCCCCCTTAATATTTAAGAATTAAAAGATGATGAGAAAT
AAGGACAAAAGCCAAGAGGAGGACAGTTCGCTACACAGCAATGCATCGAGTCACTCAGCCTCTGAAGAAGCTTCGGGTTCAGACTCAGGC
AGTCAGTCGGAAAGTGAGCAGGGAAGTGATCCAGGAAGTGGACATGGCAGCGAGTCGAACAGCAGCTCTGAATCTTCTGAGAGTCAGTCG
GAATCTGAGAGCGAATCAGCAGGTTCCAAATCCCAGCCAGTCCTCCCAGAAGCCAAAGAGAAGCCAGCCTCTAAGAAGGAACGGATAGCT
GATGTGAAGAAGATGTGGGAAGAATATCCTGATGTTTATGGGGTCAGGCGGTCAAACCGAAGCAGACAAGAACCATCGCGATTTAATATT
AAGGAAGAGGCAAGTAGCGGGTCTGAGAGTGGGAGCCCAAAAAGAAGAGGCCAGAGGCAGCTGAAAAAACAAGAAAAATGGAAACAGGAA
CCCTCAGAAGATGAACAGGAACAAGGCACCAGTGCAGAGAGTGAGCCAGAACAAAAAAAAGTAAAAGCCAGAAGACCTGTCCCCAGAAGA
ACAGTGCCCAAACCTCGTGTTAAAAAGCAGCCGAAGACTCAGCGTGGAAAGAGAAAAAAGCAAGATTCTTCTGATGAGGATGATGATGAT
GACGAAGCTCCCAAAAGGCAGACTCGTCGAAGAGCGGCTAAAAACGTTAGTTACAAAGAAGATGATGACTTTGAGACTGACTCAGATGAT
CTCATTGAAATGACTGGAGAAGGAGTTGATGAACAGCAAGATAATAGTGAAACTATTGAAAAGGTCTTAGATTCAAGACTGGGAAAGAAA
GGAGCCACTGGAGCATCTACTACTGTATATGCGATTGAAGCTAATGGCGACCCTAGTGGTGACTTTGACACTGAAAAGGATGAAGGTGAA
ATCCAGTACCTCATCAAGTGGAAGGGTTGGTCTTACATCCACAGCACATGGGAGAGTGAAGAATCCTTACAGCAACAGAAAGTGAAGGGC
CTAAAAAAACTAGAGAACTTCAAGAAAAAAGAGGACGAAATCAAACAATGGTTAGGGAAAGTTTCTCCTGAAGATGTAGAATATTTCAAT
TGCCAACAGGAGCTGGCTTCAGAGTTGAATAAACAGTATCAGATAGTAGAAAGAGTAATAGCTGTGAAGACAAGTAAATCTACATTGGGT
CAAACAGATTTTCCAGCTCATAGTCGGAAGCCGGCACCCTCAAATGAGCCCGAATATCTATGTAAATGGATGGGACTCCCCTATTCAGAG
TGTAGCTGGGAAGATGAAGCCCTCATTGGAAAGAAATTCCAGAATTGCATTGACAGCTTCCACAGTAGGAACAACTCAAAAACCATCCCA
ACAAGAGAATGCAAGGCCCTGAAGCAGAGACCACGATTTGTAGCTTTAAAGAAACAACCTGCATATTTAGGAGGGGAGAATCTGGAACTT
CGAGATTATCAGCTAGAAGGTCTAAACTGGCTAGCTCATTCCTGGTGCAAAAATAATAGTGTAATCCTTGCTGATGAAATGGGCCTAGGA
AAGACCATCCAGACCATATCATTCCTCTCCTACCTGTTCCACCAACACCAGCTGTATGGCCCCTTTCTTATAGTCGTCCCTTTATCCACC
CTCACCTCATGGCAGAGAGAGTTTGAAATCTGGGCACCAGAGATTAACGTAGTGGTTTACATAGGTGACCTGATGAGCAGAAATACGTTT
GCAGAGAAATTCCAGGAGGTGAAAGAAGCTGCCAAGATAGCCAAAGACAAGACGCAGGAGAAAATCGAGACCTCAAGTAATCATTCCCAA
GCATCCAGTGTCAACGGGACGGACGATGAAAAGGCCTCTCACGCCGGTCCAGCCAACACACACCTGAAGTCTGAGAATGACAAGCTGAAG
ATTGCCTTGACGCAGAGCGCAGCCAACGTGAAGAAGTGGGAGATCGAGCTGCAGACCCTTCGGGAGAGCAATGCACGGCTGACCACAGCA
CTGCAGGAGTCGGCAGCCAGTGTGGAGCAGTGGAAGAGGCAGTTCTCCATCTGCCGTGATGAGAATGACCGGCTCCGCAACAAGATTGAT
GAGCTGGAAGAACAATGCAGTGAGATCAACAGAGAGAAGGAGAAGAACACGCAGCTGAAGAGGAGGATCGAGGAGCTGGAGGCAGAGCTC
CGAGAAAAGGAGACAGAGCTGAAAGATCTCCGAAAACAAAGTGAAATCATACCTCAGCTCATGTCAGAGTGCGAATATGTCTCTGAGAAG
CTAGAGGCGGCAGAGAGAGACAATCAAAACCTGGAAGACAAAGTGCGTTCCTTAAAGACAGACATTGAGGAGAGCAAATACCGACAGCGC
CACCTGAAGGTGGAGTTGAAGAGCTTCCTGGAGGTGCTGGACGGGAAGATTGACGACCTGCATGACTTCCGCCGAGGGCTCTCCAAGCTG
GGCACCGATAACTAGGGCTGGCCGAGGCCCAGGCCCCGCCCGTGAGTCCCAAGCGTGTGTGCGAGACCAGATAGCTCTAGGACGTTCTTC
TGTGTGCATTGCTTCTGTAAATGCAGGCGCAGTTTGTCGTGTTTCCAAACCAGTTGTGCCGTCCACTCACTCCTTTTCAGAATAGAAATC
TCCTCTCGCTTCTCTGGCCTTGTGAGGTTGTGGACAACTGGAAGATTCTGACTCAGGAATCCAGAACTAGGTCTACCTTCAACATTTATG
CAGTCAGGGCAGGGATGTTTATATCTTTCATAAGGGCTGTTGCAACCATATGAACTGAAAAAACACGCATTTTGTAATCCAAATATTGAT
ATTCTTTACACCAAGCCATCAGGCTCCTTTTATCAAATAGCATTCAGAGTATTTGAATGTCCACCAGACACCAGCCCCGGGGGGCACAGA
GAGAACAACATTCCTCTCTGTCAACATCGAGAGGCTTTAAAACAACTGTTTAGTGGAAACTTTCTGAGAGATGGAAAACAAGCTTCTGGT
GGGTGCATTTTCTGGCCCGGAGTTGCCTGCATCCACGCTACTGCCCCCTGCCCCCCGCCCCCCCAGTTTGTACGGTTGCAACAGTGTTCC
TTTTCTTGGTTTTAATTTCTGAGCAGATGATTGTGCTGTGGGAACAGCACACAGTGAGGGTGCCTAGCACAATGTCTGGCACAAAGTAGG
TGCTTAATAAATATTTGTTCAATTAAA

>16301_16301_4_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000394196_HOMER2_chr15_83533011_ENST00000450735_length(amino acids)=818AA_BP=573
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSEN
DKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEEL
EAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRG
LSKLGTDN

--------------------------------------------------------------
>16301_16301_5_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000557381_HOMER2_chr15_83533011_ENST00000304231_length(transcript)=3929nt_BP=2426nt
CCCTGGGATGGAGGATCTGTCTCTCTCTCTCTCTCTCCTTTTTTTTTTTTTGGTGGAGATGAAGGGGTGGGTCTATGGTACATCACCTGA
GTTGTGGGGTAAATGTAGAGAGTGTCAATCAAAGGCAGAGCTCTCAGAGCTGGGAAGGAGGCTCTAGATGGCGGCTGTGCCTTAGAGAGA
GCGCGCTCTGCTCCCTGCCTTTGCCTCACTTTACGCAACTTTCCCTAACTTTCGGGCAGCCTCAGGGGGCCCCCGTAGCCCCCTGCCTTT
CCTAGGGACTTACTGGGGTCGATTCGAACCTTTTTTTGGGAGAAAAGCAGCTTTTAGGAGCTTTCTTTTCGTGCCTTGTTGGAAAGAAGC
AGCCGTACTGAGAGCCCAGGTCGTTGTTTTTTCCAGCTTAGAAGCCATGGCGCACCTCCATTTTTGTGCGCTCTCCTAATGAGGTTTTTT
TTCTTTCGGACCTGTTTTAGTATTAATTATTGCTTTATTTTTTTGACCAGTTAACATATTTGAGGGTTATTTTATTTATTTTTCGTTTTT
TAACGGAGGATTTTGCCTTTATTTTTAATTATTTGGGATCTGATATTTTTCTACTAGTAGATAGGACTCTTGGTTTGGACATACTACATG
GATCAGTAAATACCTGGGCACAGGACTTCAAAGCAAACACAGATTCCCCCTCCCCCTTAATATTTAAGAATTAAAAGATGATGAGAAATA
AGGACAAAAGCCAAGAGGAGGACAGTTCGCTACACAGCAATGCATCGAGTCACTCAGCCTCTGAAGAAGCTTCGGGTTCAGACTCAGGCA
GTCAGTCGGAAAGTGAGCAGGGAAGTGATCCAGGAAGTGGACATGGCAGCGAGTCGAACAGCAGCTCTGAATCTTCTGAGAGTCAGTCGG
AATCTGAGAGCGAATCAGCAGGTTCCAAATCCCAGCCAGTCCTCCCAGAAGCCAAAGAGAAGCCAGCCTCTAAGAAGGAACGGATAGCTG
ATGTGAAGAAGATGTGGGAAGAATATCCTGATGTTTATGGGGTCAGGCGGTCAAACCGAAGCAGACAAGAACCATCGCGATTTAATATTA
AGGAAGAGGCAAGTAGCGGGTCTGAGAGTGGGAGCCCAAAAAGAAGAGGCCAGAGGCAGCTGAAAAAACAAGAAAAATGGAAACAGGAAC
CCTCAGAAGATGAACAGGAACAAGGCACCAGTGCAGAGAGTGAGCCAGAACAAAAAAAAGTAAAAGCCAGAAGACCTGTCCCCAGAAGAA
CAGTGCCCAAACCTCGTGTTAAAAAGCAGCCGAAGACTCAGCGTGGAAAGAGAAAAAAGCAAGATTCTTCTGATGAGGATGATGATGATG
ACGAAGCTCCCAAAAGGCAGACTCGTCGAAGAGCGGCTAAAAACGTTAGTTACAAAGAAGATGATGACTTTGAGACTGACTCAGATGATC
TCATTGAAATGACTGGAGAAGGAGTTGATGAACAGCAAGATAATAGTGAAACTATTGAAAAGGTCTTAGATTCAAGACTGGGAAAGAAAG
GAGCCACTGGAGCATCTACTACTGTATATGCGATTGAAGCTAATGGCGACCCTAGTGGTGACTTTGACACTGAAAAGGATGAAGGTGAAA
TCCAGTACCTCATCAAGTGGAAGGGTTGGTCTTACATCCACAGCACATGGGAGAGTGAAGAATCCTTACAGCAACAGAAAGTGAAGGGCC
TAAAAAAACTAGAGAACTTCAAGAAAAAAGAGGACGAAATCAAACAATGGTTAGGGAAAGTTTCTCCTGAAGATGTAGAATATTTCAATT
GCCAACAGGAGCTGGCTTCAGAGTTGAATAAACAGTATCAGATAGTAGAAAGAGTAATAGCTGTGAAGACAAGTAAATCTACATTGGGTC
AAACAGATTTTCCAGCTCATAGTCGGAAGCCGGCACCCTCAAATGAGCCCGAATATCTATGTAAATGGATGGGACTCCCCTATTCAGAGT
GTAGCTGGGAAGATGAAGCCCTCATTGGAAAGAAATTCCAGAATTGCATTGACAGCTTCCACAGTAGGAACAACTCAAAAACCATCCCAA
CAAGAGAATGCAAGGCCCTGAAGCAGAGACCACGATTTGTAGCTTTAAAGAAACAACCTGCATATTTAGGAGGGGAGAATCTGGAACTTC
GAGATTATCAGCTAGAAGGTCTAAACTGGCTAGCTCATTCCTGGTGCAAAAATAATAGTGTAATCCTTGCTGATGAAATGGGCCTAGGAA
AGACCATCCAGACCATATCATTCCTCTCCTACCTGTTCCACCAACACCAGCTGTATGGCCCCTTTCTTATAGTCGTCCCTTTATCCACCC
TCACCTCATGGCAGAGAGAGTTTGAAATCTGGGCACCAGAGATTAACGTAGTGGTTTACATAGGTGACCTGATGAGCAGAAATACGTTTG
CAGAGAAATTCCAGGAGGTGAAAGAAGCTGCCAAGATAGCCAAAGACAAGACGCAGGAGAAAATCGAGACCTCAAGTAATCATTCCCAAG
AATCTGGGCGTGAAACCCCATCTTCTACTCAGGCATCCAGTGTCAACGGGACGGACGATGAAAAGGCCTCTCACGCCGGTCCAGCCAACA
CACACCTGAAGTCTGAGAATGACAAGCTGAAGATTGCCTTGACGCAGAGCGCAGCCAACGTGAAGAAGTGGGAGATCGAGCTGCAGACCC
TTCGGGAGAGCAATGCACGGCTGACCACAGCACTGCAGGAGTCGGCAGCCAGTGTGGAGCAGTGGAAGAGGCAGTTCTCCATCTGCCGTG
ATGAGAATGACCGGCTCCGCAACAAGATTGATGAGCTGGAAGAACAATGCAGTGAGATCAACAGAGAGAAGGAGAAGAACACGCAGCTGA
AGAGGAGGATCGAGGAGCTGGAGGCAGAGCTCCGAGAAAAGGAGACAGAGCTGAAAGATCTCCGAAAACAAAGTGAAATCATACCTCAGC
TCATGTCAGAGTGCGAATATGTCTCTGAGAAGCTAGAGGCGGCAGAGAGAGACAATCAAAACCTGGAAGACAAAGTGCGTTCCTTAAAGA
CAGACATTGAGGAGAGCAAATACCGACAGCGCCACCTGAAGGTGGAGTTGAAGAGCTTCCTGGAGGTGCTGGACGGGAAGATTGACGACC
TGCATGACTTCCGCCGAGGGCTCTCCAAGCTGGGCACCGATAACTAGGGCTGGCCGAGGCCCAGGCCCCGCCCGTGAGTCCCAAGCGTGT
GTGCGAGACCAGATAGCTCTAGGACGTTCTTCTGTGTGCATTGCTTCTGTAAATGCAGGCGCAGTTTGTCGTGTTTCCAAACCAGTTGTG
CCGTCCACTCACTCCTTTTCAGAATAGAAATCTCCTCTCGCTTCTCTGGCCTTGTGAGGTTGTGGACAACTGGAAGATTCTGACTCAGGA
ATCCAGAACTAGGTCTACCTTCAACATTTATGCAGTCAGGGCAGGGATGTTTATATCTTTCATAAGGGCTGTTGCAACCATATGAACTGA
AAAAACACGCATTTTGTAATCCAAATATTGATATTCTTTACACCAAGCCATCAGGCTCCTTTTATCAAATAGCATTCAGAGTATTTGAAT
GTCCACCAGACACCAGCCCCGGGGGGCACAGAGAGAACAACATTCCTCTCTGTCAACATCGAGAGGCTTTAAAACAACTGTTTAGTGGAA
ACTTTCTGAGAGATGGAAAACAAGCTTCTGGTGGGTGCATTTTCTGGCCCGGAGTTGCCTGCATCCACGCTACTGCCCCCTGCCCCCCGC
CCCCCCAGTTTGTACGGTTGCAACAGTGTTCCTTTTCTTGGTTTTAATTTCTGAGCAGATGATTGTGCTGTGGGAACAGCACACAGTGAG
GGTGCCTAGCACAATGTCTGGCACAAAGTAGGTGCTTAATAAATATTTGTTCAATTAAA

>16301_16301_5_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000557381_HOMER2_chr15_83533011_ENST00000304231_length(amino acids)=829AA_BP=573
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHA
GPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEK
NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDG
KIDDLHDFRRGLSKLGTDN

--------------------------------------------------------------
>16301_16301_6_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000557381_HOMER2_chr15_83533011_ENST00000399166_length(transcript)=3728nt_BP=2426nt
CCCTGGGATGGAGGATCTGTCTCTCTCTCTCTCTCTCCTTTTTTTTTTTTTGGTGGAGATGAAGGGGTGGGTCTATGGTACATCACCTGA
GTTGTGGGGTAAATGTAGAGAGTGTCAATCAAAGGCAGAGCTCTCAGAGCTGGGAAGGAGGCTCTAGATGGCGGCTGTGCCTTAGAGAGA
GCGCGCTCTGCTCCCTGCCTTTGCCTCACTTTACGCAACTTTCCCTAACTTTCGGGCAGCCTCAGGGGGCCCCCGTAGCCCCCTGCCTTT
CCTAGGGACTTACTGGGGTCGATTCGAACCTTTTTTTGGGAGAAAAGCAGCTTTTAGGAGCTTTCTTTTCGTGCCTTGTTGGAAAGAAGC
AGCCGTACTGAGAGCCCAGGTCGTTGTTTTTTCCAGCTTAGAAGCCATGGCGCACCTCCATTTTTGTGCGCTCTCCTAATGAGGTTTTTT
TTCTTTCGGACCTGTTTTAGTATTAATTATTGCTTTATTTTTTTGACCAGTTAACATATTTGAGGGTTATTTTATTTATTTTTCGTTTTT
TAACGGAGGATTTTGCCTTTATTTTTAATTATTTGGGATCTGATATTTTTCTACTAGTAGATAGGACTCTTGGTTTGGACATACTACATG
GATCAGTAAATACCTGGGCACAGGACTTCAAAGCAAACACAGATTCCCCCTCCCCCTTAATATTTAAGAATTAAAAGATGATGAGAAATA
AGGACAAAAGCCAAGAGGAGGACAGTTCGCTACACAGCAATGCATCGAGTCACTCAGCCTCTGAAGAAGCTTCGGGTTCAGACTCAGGCA
GTCAGTCGGAAAGTGAGCAGGGAAGTGATCCAGGAAGTGGACATGGCAGCGAGTCGAACAGCAGCTCTGAATCTTCTGAGAGTCAGTCGG
AATCTGAGAGCGAATCAGCAGGTTCCAAATCCCAGCCAGTCCTCCCAGAAGCCAAAGAGAAGCCAGCCTCTAAGAAGGAACGGATAGCTG
ATGTGAAGAAGATGTGGGAAGAATATCCTGATGTTTATGGGGTCAGGCGGTCAAACCGAAGCAGACAAGAACCATCGCGATTTAATATTA
AGGAAGAGGCAAGTAGCGGGTCTGAGAGTGGGAGCCCAAAAAGAAGAGGCCAGAGGCAGCTGAAAAAACAAGAAAAATGGAAACAGGAAC
CCTCAGAAGATGAACAGGAACAAGGCACCAGTGCAGAGAGTGAGCCAGAACAAAAAAAAGTAAAAGCCAGAAGACCTGTCCCCAGAAGAA
CAGTGCCCAAACCTCGTGTTAAAAAGCAGCCGAAGACTCAGCGTGGAAAGAGAAAAAAGCAAGATTCTTCTGATGAGGATGATGATGATG
ACGAAGCTCCCAAAAGGCAGACTCGTCGAAGAGCGGCTAAAAACGTTAGTTACAAAGAAGATGATGACTTTGAGACTGACTCAGATGATC
TCATTGAAATGACTGGAGAAGGAGTTGATGAACAGCAAGATAATAGTGAAACTATTGAAAAGGTCTTAGATTCAAGACTGGGAAAGAAAG
GAGCCACTGGAGCATCTACTACTGTATATGCGATTGAAGCTAATGGCGACCCTAGTGGTGACTTTGACACTGAAAAGGATGAAGGTGAAA
TCCAGTACCTCATCAAGTGGAAGGGTTGGTCTTACATCCACAGCACATGGGAGAGTGAAGAATCCTTACAGCAACAGAAAGTGAAGGGCC
TAAAAAAACTAGAGAACTTCAAGAAAAAAGAGGACGAAATCAAACAATGGTTAGGGAAAGTTTCTCCTGAAGATGTAGAATATTTCAATT
GCCAACAGGAGCTGGCTTCAGAGTTGAATAAACAGTATCAGATAGTAGAAAGAGTAATAGCTGTGAAGACAAGTAAATCTACATTGGGTC
AAACAGATTTTCCAGCTCATAGTCGGAAGCCGGCACCCTCAAATGAGCCCGAATATCTATGTAAATGGATGGGACTCCCCTATTCAGAGT
GTAGCTGGGAAGATGAAGCCCTCATTGGAAAGAAATTCCAGAATTGCATTGACAGCTTCCACAGTAGGAACAACTCAAAAACCATCCCAA
CAAGAGAATGCAAGGCCCTGAAGCAGAGACCACGATTTGTAGCTTTAAAGAAACAACCTGCATATTTAGGAGGGGAGAATCTGGAACTTC
GAGATTATCAGCTAGAAGGTCTAAACTGGCTAGCTCATTCCTGGTGCAAAAATAATAGTGTAATCCTTGCTGATGAAATGGGCCTAGGAA
AGACCATCCAGACCATATCATTCCTCTCCTACCTGTTCCACCAACACCAGCTGTATGGCCCCTTTCTTATAGTCGTCCCTTTATCCACCC
TCACCTCATGGCAGAGAGAGTTTGAAATCTGGGCACCAGAGATTAACGTAGTGGTTTACATAGGTGACCTGATGAGCAGAAATACGTTTG
CAGAGAAATTCCAGGAGGTGAAAGAAGCTGCCAAGATAGCCAAAGACAAGACGCAGGAGAAAATCGAGACCTCAAGTAATCATTCCCAAG
CATCCAGTGTCAACGGGACGGACGATGAAAAGGCCTCTCACGCCGGTCCAGCCAACACACACCTGAAGTCTGAGAATGACAAGCTGAAGA
TTGCCTTGACGCAGAGCGCAGCCAACGTGAAGAATGAGATCAACAGAGAGAAGGAGAAGAACACGCAGCTGAAGAGGAGGATCGAGGAGC
TGGAGGCAGAGCTCCGAGAAAAGGAGACAGAGCTGAAAGATCTCCGAAAACAAAGTGAAATCATACCTCAGCTCATGTCAGAGTGCGAAT
ATGTCTCTGAGAAGCTAGAGGCGGCAGAGAGAGACAATCAAAACCTGGAAGACAAAGTGCGTTCCTTAAAGACAGACATTGAGGAGAGCA
AATACCGACAGCGCCACCTGAAGGTGGAGTTGAAGAGCTTCCTGGAGGTGCTGGACGGGAAGATTGACGACCTGCATGACTTCCGCCGAG
GGCTCTCCAAGCTGGGCACCGATAACTAGGGCTGGCCGAGGCCCAGGCCCCGCCCGTGAGTCCCAAGCGTGTGTGCGAGACCAGATAGCT
CTAGGACGTTCTTCTGTGTGCATTGCTTCTGTAAATGCAGGCGCAGTTTGTCGTGTTTCCAAACCAGTTGTGCCGTCCACTCACTCCTTT
TCAGAATAGAAATCTCCTCTCGCTTCTCTGGCCTTGTGAGGTTGTGGACAACTGGAAGATTCTGACTCAGGAATCCAGAACTAGGTCTAC
CTTCAACATTTATGCAGTCAGGGCAGGGATGTTTATATCTTTCATAAGGGCTGTTGCAACCATATGAACTGAAAAAACACGCATTTTGTA
ATCCAAATATTGATATTCTTTACACCAAGCCATCAGGCTCCTTTTATCAAATAGCATTCAGAGTATTTGAATGTCCACCAGACACCAGCC
CCGGGGGGCACAGAGAGAACAACATTCCTCTCTGTCAACATCGAGAGGCTTTAAAACAACTGTTTAGTGGAAACTTTCTGAGAGATGGAA
AACAAGCTTCTGGTGGGTGCATTTTCTGGCCCGGAGTTGCCTGCATCCACGCTACTGCCCCCTGCCCCCCGCCCCCCCAGTTTGTACGGT
TGCAACAGTGTTCCTTTTCTTGGTTTTAATTTCTGAGCAGATGATTGTGCTGTGGGAACAGCACACAGTGAGGGTGCCTAGCACAATGTC
TGGCACAAAGTAGGTGCTTAATAAATATTTGTTCAATT

>16301_16301_6_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000557381_HOMER2_chr15_83533011_ENST00000399166_length(amino acids)=763AA_BP=573
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSEN
DKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD
IEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN

--------------------------------------------------------------
>16301_16301_7_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000557381_HOMER2_chr15_83533011_ENST00000426485_length(transcript)=3761nt_BP=2426nt
CCCTGGGATGGAGGATCTGTCTCTCTCTCTCTCTCTCCTTTTTTTTTTTTTGGTGGAGATGAAGGGGTGGGTCTATGGTACATCACCTGA
GTTGTGGGGTAAATGTAGAGAGTGTCAATCAAAGGCAGAGCTCTCAGAGCTGGGAAGGAGGCTCTAGATGGCGGCTGTGCCTTAGAGAGA
GCGCGCTCTGCTCCCTGCCTTTGCCTCACTTTACGCAACTTTCCCTAACTTTCGGGCAGCCTCAGGGGGCCCCCGTAGCCCCCTGCCTTT
CCTAGGGACTTACTGGGGTCGATTCGAACCTTTTTTTGGGAGAAAAGCAGCTTTTAGGAGCTTTCTTTTCGTGCCTTGTTGGAAAGAAGC
AGCCGTACTGAGAGCCCAGGTCGTTGTTTTTTCCAGCTTAGAAGCCATGGCGCACCTCCATTTTTGTGCGCTCTCCTAATGAGGTTTTTT
TTCTTTCGGACCTGTTTTAGTATTAATTATTGCTTTATTTTTTTGACCAGTTAACATATTTGAGGGTTATTTTATTTATTTTTCGTTTTT
TAACGGAGGATTTTGCCTTTATTTTTAATTATTTGGGATCTGATATTTTTCTACTAGTAGATAGGACTCTTGGTTTGGACATACTACATG
GATCAGTAAATACCTGGGCACAGGACTTCAAAGCAAACACAGATTCCCCCTCCCCCTTAATATTTAAGAATTAAAAGATGATGAGAAATA
AGGACAAAAGCCAAGAGGAGGACAGTTCGCTACACAGCAATGCATCGAGTCACTCAGCCTCTGAAGAAGCTTCGGGTTCAGACTCAGGCA
GTCAGTCGGAAAGTGAGCAGGGAAGTGATCCAGGAAGTGGACATGGCAGCGAGTCGAACAGCAGCTCTGAATCTTCTGAGAGTCAGTCGG
AATCTGAGAGCGAATCAGCAGGTTCCAAATCCCAGCCAGTCCTCCCAGAAGCCAAAGAGAAGCCAGCCTCTAAGAAGGAACGGATAGCTG
ATGTGAAGAAGATGTGGGAAGAATATCCTGATGTTTATGGGGTCAGGCGGTCAAACCGAAGCAGACAAGAACCATCGCGATTTAATATTA
AGGAAGAGGCAAGTAGCGGGTCTGAGAGTGGGAGCCCAAAAAGAAGAGGCCAGAGGCAGCTGAAAAAACAAGAAAAATGGAAACAGGAAC
CCTCAGAAGATGAACAGGAACAAGGCACCAGTGCAGAGAGTGAGCCAGAACAAAAAAAAGTAAAAGCCAGAAGACCTGTCCCCAGAAGAA
CAGTGCCCAAACCTCGTGTTAAAAAGCAGCCGAAGACTCAGCGTGGAAAGAGAAAAAAGCAAGATTCTTCTGATGAGGATGATGATGATG
ACGAAGCTCCCAAAAGGCAGACTCGTCGAAGAGCGGCTAAAAACGTTAGTTACAAAGAAGATGATGACTTTGAGACTGACTCAGATGATC
TCATTGAAATGACTGGAGAAGGAGTTGATGAACAGCAAGATAATAGTGAAACTATTGAAAAGGTCTTAGATTCAAGACTGGGAAAGAAAG
GAGCCACTGGAGCATCTACTACTGTATATGCGATTGAAGCTAATGGCGACCCTAGTGGTGACTTTGACACTGAAAAGGATGAAGGTGAAA
TCCAGTACCTCATCAAGTGGAAGGGTTGGTCTTACATCCACAGCACATGGGAGAGTGAAGAATCCTTACAGCAACAGAAAGTGAAGGGCC
TAAAAAAACTAGAGAACTTCAAGAAAAAAGAGGACGAAATCAAACAATGGTTAGGGAAAGTTTCTCCTGAAGATGTAGAATATTTCAATT
GCCAACAGGAGCTGGCTTCAGAGTTGAATAAACAGTATCAGATAGTAGAAAGAGTAATAGCTGTGAAGACAAGTAAATCTACATTGGGTC
AAACAGATTTTCCAGCTCATAGTCGGAAGCCGGCACCCTCAAATGAGCCCGAATATCTATGTAAATGGATGGGACTCCCCTATTCAGAGT
GTAGCTGGGAAGATGAAGCCCTCATTGGAAAGAAATTCCAGAATTGCATTGACAGCTTCCACAGTAGGAACAACTCAAAAACCATCCCAA
CAAGAGAATGCAAGGCCCTGAAGCAGAGACCACGATTTGTAGCTTTAAAGAAACAACCTGCATATTTAGGAGGGGAGAATCTGGAACTTC
GAGATTATCAGCTAGAAGGTCTAAACTGGCTAGCTCATTCCTGGTGCAAAAATAATAGTGTAATCCTTGCTGATGAAATGGGCCTAGGAA
AGACCATCCAGACCATATCATTCCTCTCCTACCTGTTCCACCAACACCAGCTGTATGGCCCCTTTCTTATAGTCGTCCCTTTATCCACCC
TCACCTCATGGCAGAGAGAGTTTGAAATCTGGGCACCAGAGATTAACGTAGTGGTTTACATAGGTGACCTGATGAGCAGAAATACGTTTG
CAGAGAAATTCCAGGAGGTGAAAGAAGCTGCCAAGATAGCCAAAGACAAGACGCAGGAGAAAATCGAGACCTCAAGTAATCATTCCCAAG
AATCTGGGCGTGAAACCCCATCTTCTACTCAGGCATCCAGTGTCAACGGGACGGACGATGAAAAGGCCTCTCACGCCGGTCCAGCCAACA
CACACCTGAAGTCTGAGAATGACAAGCTGAAGATTGCCTTGACGCAGAGCGCAGCCAACGTGAAGAATGAGATCAACAGAGAGAAGGAGA
AGAACACGCAGCTGAAGAGGAGGATCGAGGAGCTGGAGGCAGAGCTCCGAGAAAAGGAGACAGAGCTGAAAGATCTCCGAAAACAAAGTG
AAATCATACCTCAGCTCATGTCAGAGTGCGAATATGTCTCTGAGAAGCTAGAGGCGGCAGAGAGAGACAATCAAAACCTGGAAGACAAAG
TGCGTTCCTTAAAGACAGACATTGAGGAGAGCAAATACCGACAGCGCCACCTGAAGGTGGAGTTGAAGAGCTTCCTGGAGGTGCTGGACG
GGAAGATTGACGACCTGCATGACTTCCGCCGAGGGCTCTCCAAGCTGGGCACCGATAACTAGGGCTGGCCGAGGCCCAGGCCCCGCCCGT
GAGTCCCAAGCGTGTGTGCGAGACCAGATAGCTCTAGGACGTTCTTCTGTGTGCATTGCTTCTGTAAATGCAGGCGCAGTTTGTCGTGTT
TCCAAACCAGTTGTGCCGTCCACTCACTCCTTTTCAGAATAGAAATCTCCTCTCGCTTCTCTGGCCTTGTGAGGTTGTGGACAACTGGAA
GATTCTGACTCAGGAATCCAGAACTAGGTCTACCTTCAACATTTATGCAGTCAGGGCAGGGATGTTTATATCTTTCATAAGGGCTGTTGC
AACCATATGAACTGAAAAAACACGCATTTTGTAATCCAAATATTGATATTCTTTACACCAAGCCATCAGGCTCCTTTTATCAAATAGCAT
TCAGAGTATTTGAATGTCCACCAGACACCAGCCCCGGGGGGCACAGAGAGAACAACATTCCTCTCTGTCAACATCGAGAGGCTTTAAAAC
AACTGTTTAGTGGAAACTTTCTGAGAGATGGAAAACAAGCTTCTGGTGGGTGCATTTTCTGGCCCGGAGTTGCCTGCATCCACGCTACTG
CCCCCTGCCCCCCGCCCCCCCAGTTTGTACGGTTGCAACAGTGTTCCTTTTCTTGGTTTTAATTTCTGAGCAGATGATTGTGCTGTGGGA
ACAGCACACAGTGAGGGTGCCTAGCACAATGTCTGGCACAAAGTAGGTGCTTAATAAATATTTGTTCAATT

>16301_16301_7_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000557381_HOMER2_chr15_83533011_ENST00000426485_length(amino acids)=774AA_BP=573
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHA
GPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN
LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN

--------------------------------------------------------------
>16301_16301_8_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000557381_HOMER2_chr15_83533011_ENST00000450735_length(transcript)=3896nt_BP=2426nt
CCCTGGGATGGAGGATCTGTCTCTCTCTCTCTCTCTCCTTTTTTTTTTTTTGGTGGAGATGAAGGGGTGGGTCTATGGTACATCACCTGA
GTTGTGGGGTAAATGTAGAGAGTGTCAATCAAAGGCAGAGCTCTCAGAGCTGGGAAGGAGGCTCTAGATGGCGGCTGTGCCTTAGAGAGA
GCGCGCTCTGCTCCCTGCCTTTGCCTCACTTTACGCAACTTTCCCTAACTTTCGGGCAGCCTCAGGGGGCCCCCGTAGCCCCCTGCCTTT
CCTAGGGACTTACTGGGGTCGATTCGAACCTTTTTTTGGGAGAAAAGCAGCTTTTAGGAGCTTTCTTTTCGTGCCTTGTTGGAAAGAAGC
AGCCGTACTGAGAGCCCAGGTCGTTGTTTTTTCCAGCTTAGAAGCCATGGCGCACCTCCATTTTTGTGCGCTCTCCTAATGAGGTTTTTT
TTCTTTCGGACCTGTTTTAGTATTAATTATTGCTTTATTTTTTTGACCAGTTAACATATTTGAGGGTTATTTTATTTATTTTTCGTTTTT
TAACGGAGGATTTTGCCTTTATTTTTAATTATTTGGGATCTGATATTTTTCTACTAGTAGATAGGACTCTTGGTTTGGACATACTACATG
GATCAGTAAATACCTGGGCACAGGACTTCAAAGCAAACACAGATTCCCCCTCCCCCTTAATATTTAAGAATTAAAAGATGATGAGAAATA
AGGACAAAAGCCAAGAGGAGGACAGTTCGCTACACAGCAATGCATCGAGTCACTCAGCCTCTGAAGAAGCTTCGGGTTCAGACTCAGGCA
GTCAGTCGGAAAGTGAGCAGGGAAGTGATCCAGGAAGTGGACATGGCAGCGAGTCGAACAGCAGCTCTGAATCTTCTGAGAGTCAGTCGG
AATCTGAGAGCGAATCAGCAGGTTCCAAATCCCAGCCAGTCCTCCCAGAAGCCAAAGAGAAGCCAGCCTCTAAGAAGGAACGGATAGCTG
ATGTGAAGAAGATGTGGGAAGAATATCCTGATGTTTATGGGGTCAGGCGGTCAAACCGAAGCAGACAAGAACCATCGCGATTTAATATTA
AGGAAGAGGCAAGTAGCGGGTCTGAGAGTGGGAGCCCAAAAAGAAGAGGCCAGAGGCAGCTGAAAAAACAAGAAAAATGGAAACAGGAAC
CCTCAGAAGATGAACAGGAACAAGGCACCAGTGCAGAGAGTGAGCCAGAACAAAAAAAAGTAAAAGCCAGAAGACCTGTCCCCAGAAGAA
CAGTGCCCAAACCTCGTGTTAAAAAGCAGCCGAAGACTCAGCGTGGAAAGAGAAAAAAGCAAGATTCTTCTGATGAGGATGATGATGATG
ACGAAGCTCCCAAAAGGCAGACTCGTCGAAGAGCGGCTAAAAACGTTAGTTACAAAGAAGATGATGACTTTGAGACTGACTCAGATGATC
TCATTGAAATGACTGGAGAAGGAGTTGATGAACAGCAAGATAATAGTGAAACTATTGAAAAGGTCTTAGATTCAAGACTGGGAAAGAAAG
GAGCCACTGGAGCATCTACTACTGTATATGCGATTGAAGCTAATGGCGACCCTAGTGGTGACTTTGACACTGAAAAGGATGAAGGTGAAA
TCCAGTACCTCATCAAGTGGAAGGGTTGGTCTTACATCCACAGCACATGGGAGAGTGAAGAATCCTTACAGCAACAGAAAGTGAAGGGCC
TAAAAAAACTAGAGAACTTCAAGAAAAAAGAGGACGAAATCAAACAATGGTTAGGGAAAGTTTCTCCTGAAGATGTAGAATATTTCAATT
GCCAACAGGAGCTGGCTTCAGAGTTGAATAAACAGTATCAGATAGTAGAAAGAGTAATAGCTGTGAAGACAAGTAAATCTACATTGGGTC
AAACAGATTTTCCAGCTCATAGTCGGAAGCCGGCACCCTCAAATGAGCCCGAATATCTATGTAAATGGATGGGACTCCCCTATTCAGAGT
GTAGCTGGGAAGATGAAGCCCTCATTGGAAAGAAATTCCAGAATTGCATTGACAGCTTCCACAGTAGGAACAACTCAAAAACCATCCCAA
CAAGAGAATGCAAGGCCCTGAAGCAGAGACCACGATTTGTAGCTTTAAAGAAACAACCTGCATATTTAGGAGGGGAGAATCTGGAACTTC
GAGATTATCAGCTAGAAGGTCTAAACTGGCTAGCTCATTCCTGGTGCAAAAATAATAGTGTAATCCTTGCTGATGAAATGGGCCTAGGAA
AGACCATCCAGACCATATCATTCCTCTCCTACCTGTTCCACCAACACCAGCTGTATGGCCCCTTTCTTATAGTCGTCCCTTTATCCACCC
TCACCTCATGGCAGAGAGAGTTTGAAATCTGGGCACCAGAGATTAACGTAGTGGTTTACATAGGTGACCTGATGAGCAGAAATACGTTTG
CAGAGAAATTCCAGGAGGTGAAAGAAGCTGCCAAGATAGCCAAAGACAAGACGCAGGAGAAAATCGAGACCTCAAGTAATCATTCCCAAG
CATCCAGTGTCAACGGGACGGACGATGAAAAGGCCTCTCACGCCGGTCCAGCCAACACACACCTGAAGTCTGAGAATGACAAGCTGAAGA
TTGCCTTGACGCAGAGCGCAGCCAACGTGAAGAAGTGGGAGATCGAGCTGCAGACCCTTCGGGAGAGCAATGCACGGCTGACCACAGCAC
TGCAGGAGTCGGCAGCCAGTGTGGAGCAGTGGAAGAGGCAGTTCTCCATCTGCCGTGATGAGAATGACCGGCTCCGCAACAAGATTGATG
AGCTGGAAGAACAATGCAGTGAGATCAACAGAGAGAAGGAGAAGAACACGCAGCTGAAGAGGAGGATCGAGGAGCTGGAGGCAGAGCTCC
GAGAAAAGGAGACAGAGCTGAAAGATCTCCGAAAACAAAGTGAAATCATACCTCAGCTCATGTCAGAGTGCGAATATGTCTCTGAGAAGC
TAGAGGCGGCAGAGAGAGACAATCAAAACCTGGAAGACAAAGTGCGTTCCTTAAAGACAGACATTGAGGAGAGCAAATACCGACAGCGCC
ACCTGAAGGTGGAGTTGAAGAGCTTCCTGGAGGTGCTGGACGGGAAGATTGACGACCTGCATGACTTCCGCCGAGGGCTCTCCAAGCTGG
GCACCGATAACTAGGGCTGGCCGAGGCCCAGGCCCCGCCCGTGAGTCCCAAGCGTGTGTGCGAGACCAGATAGCTCTAGGACGTTCTTCT
GTGTGCATTGCTTCTGTAAATGCAGGCGCAGTTTGTCGTGTTTCCAAACCAGTTGTGCCGTCCACTCACTCCTTTTCAGAATAGAAATCT
CCTCTCGCTTCTCTGGCCTTGTGAGGTTGTGGACAACTGGAAGATTCTGACTCAGGAATCCAGAACTAGGTCTACCTTCAACATTTATGC
AGTCAGGGCAGGGATGTTTATATCTTTCATAAGGGCTGTTGCAACCATATGAACTGAAAAAACACGCATTTTGTAATCCAAATATTGATA
TTCTTTACACCAAGCCATCAGGCTCCTTTTATCAAATAGCATTCAGAGTATTTGAATGTCCACCAGACACCAGCCCCGGGGGGCACAGAG
AGAACAACATTCCTCTCTGTCAACATCGAGAGGCTTTAAAACAACTGTTTAGTGGAAACTTTCTGAGAGATGGAAAACAAGCTTCTGGTG
GGTGCATTTTCTGGCCCGGAGTTGCCTGCATCCACGCTACTGCCCCCTGCCCCCCGCCCCCCCAGTTTGTACGGTTGCAACAGTGTTCCT
TTTCTTGGTTTTAATTTCTGAGCAGATGATTGTGCTGTGGGAACAGCACACAGTGAGGGTGCCTAGCACAATGTCTGGCACAAAGTAGGT
GCTTAATAAATATTTGTTCAATTAAA

>16301_16301_8_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000557381_HOMER2_chr15_83533011_ENST00000450735_length(amino acids)=818AA_BP=573
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSEN
DKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEEL
EAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRG
LSKLGTDN

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Fusion Gene PPI Analysis for CHD2-HOMER2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHD2-HOMER2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHD2-HOMER2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCHD2C0014544Epilepsy2CTD_human
HgeneCHD2C0086237Epilepsy, Cryptogenic2CTD_human
HgeneCHD2C0236018Aura2CTD_human
HgeneCHD2C0751111Awakening Epilepsy2CTD_human
HgeneCHD2C3809278EPILEPTIC ENCEPHALOPATHY, CHILDHOOD-ONSET2GENOMICS_ENGLAND;UNIPROT
HgeneCHD2C0040517Gilles de la Tourette syndrome1GENOMICS_ENGLAND
HgeneCHD2C0238111Lennox-Gastaut syndrome1ORPHANET
HgeneCHD2C0393702Myoclonic Astatic Epilepsy1ORPHANET
HgeneCHD2C0543888Epileptic encephalopathy1GENOMICS_ENGLAND
HgeneCHD2C1510586Autism Spectrum Disorders1CTD_human
HgeneCHD2C1535926Neurodevelopmental Disorders1CTD_human
TgeneC3711374Nonsyndromic Deafness2CLINGEN
TgeneC0009171Cocaine Abuse1CTD_human
TgeneC0036341Schizophrenia1PSYGENET
TgeneC0236736Cocaine-Related Disorders1CTD_human
TgeneC0600427Cocaine Dependence1CTD_human
TgeneC4225240DEAFNESS, AUTOSOMAL DOMINANT 681CTD_human;GENOMICS_ENGLAND;UNIPROT