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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CHD4-CHD4 (FusionGDB2 ID:HG1108TG1108) |
Fusion Gene Summary for CHD4-CHD4 |
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Fusion gene information | Fusion gene name: CHD4-CHD4 | Fusion gene ID: hg1108tg1108 | Hgene | Tgene | Gene symbol | CHD4 | CHD4 | Gene ID | 1108 | 1108 |
Gene name | chromodomain helicase DNA binding protein 4 | chromodomain helicase DNA binding protein 4 | |
Synonyms | CHD-4|Mi-2b|Mi2-BETA|SIHIWES | CHD-4|Mi-2b|Mi2-BETA|SIHIWES | |
Cytomap | ('CHD4')('CHD4') 12p13.31 | 12p13.31 | |
Type of gene | protein-coding | protein-coding | |
Description | chromodomain-helicase-DNA-binding protein 4ATP-dependent helicase CHD4Mi-2 autoantigen 218 kDa protein | chromodomain-helicase-DNA-binding protein 4ATP-dependent helicase CHD4Mi-2 autoantigen 218 kDa protein | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q14839 | Q14839 | |
Ensembl transtripts involved in fusion gene | ENST00000309577, ENST00000357008, ENST00000540960, ENST00000544040, ENST00000544484, | ENST00000309577, ENST00000357008, ENST00000544040, ENST00000544484, ENST00000540960, | |
Fusion gene scores | * DoF score | 14 X 21 X 8=2352 | 13 X 16 X 7=1456 |
# samples | 20 | 17 | |
** MAII score | log2(20/2352*10)=-3.55581615506164 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(17/1456*10)=-3.098403704061 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CHD4 [Title/Abstract] AND CHD4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CHD4(6679616)-CHD4(6691366), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for CHD4-CHD4 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CHD4-CHD4 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CHD4-CHD4 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:6679616/:6691366) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CHD4 | CHD4 |
FUNCTION: Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:9804427}. | FUNCTION: Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:9804427}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CHD4-CHD4 |
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Fusion Gene PPI Analysis for CHD4-CHD4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CHD4-CHD4 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CHD4-CHD4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CHD4 | C4310688 | SIFRIM-HITZ-WEISS SYNDROME | 2 | GENOMICS_ENGLAND;UNIPROT |
Hgene | CHD4 | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | CHD4 | C0008073 | Developmental Disabilities | 1 | CTD_human |
Hgene | CHD4 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Hgene | CHD4 | C0036341 | Schizophrenia | 1 | CTD_human |
Hgene | CHD4 | C0085996 | Child Development Deviations | 1 | CTD_human |
Hgene | CHD4 | C0085997 | Child Development Disorders, Specific | 1 | CTD_human |
Hgene | CHD4 | C0476089 | Endometrial Carcinoma | 1 | CTD_human |
Tgene | C4310688 | SIFRIM-HITZ-WEISS SYNDROME | 2 | GENOMICS_ENGLAND;UNIPROT | |
Tgene | C0004352 | Autistic Disorder | 1 | CTD_human | |
Tgene | C0008073 | Developmental Disabilities | 1 | CTD_human | |
Tgene | C0014170 | Endometrial Neoplasms | 1 | CTD_human | |
Tgene | C0036341 | Schizophrenia | 1 | CTD_human | |
Tgene | C0085996 | Child Development Deviations | 1 | CTD_human | |
Tgene | C0085997 | Child Development Disorders, Specific | 1 | CTD_human | |
Tgene | C0476089 | Endometrial Carcinoma | 1 | CTD_human |