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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ATE1-ANXA10 (FusionGDB2 ID:HG11101TG11199) |
Fusion Gene Summary for ATE1-ANXA10 |
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Fusion gene information | Fusion gene name: ATE1-ANXA10 | Fusion gene ID: hg11101tg11199 | Hgene | Tgene | Gene symbol | ATE1 | ANXA10 | Gene ID | 11101 | 11199 |
Gene name | arginyltransferase 1 | annexin A10 | |
Synonyms | - | ANX14 | |
Cytomap | ('ATE1')('ANXA10') 10q26.13 | 4q32.3 | |
Type of gene | protein-coding | protein-coding | |
Description | arginyl-tRNA--protein transferase 1R-transferase 1arginine-tRNA--protein transferase 1arginyl-tRNA-protein transferase | annexin A10annexin 14annexin-10 | |
Modification date | 20200313 | 20200327 | |
UniProtAcc | O95260 | . | |
Ensembl transtripts involved in fusion gene | ENST00000224652, ENST00000369040, ENST00000369043, ENST00000540606, ENST00000535655, ENST00000543447, ENST00000481784, | ||
Fusion gene scores | * DoF score | 7 X 8 X 7=392 | 5 X 4 X 5=100 |
# samples | 9 | 5 | |
** MAII score | log2(9/392*10)=-2.12285674778553 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ATE1 [Title/Abstract] AND ANXA10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ATE1(123596233)-ANXA10(169060637), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | COAD | TCGA-AD-6899-01A | ATE1 | chr10 | 123596233 | - | ANXA10 | chr4 | 169060637 | + |
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Fusion Gene ORF analysis for ATE1-ANXA10 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000224652 | ENST00000359299 | ATE1 | chr10 | 123596233 | - | ANXA10 | chr4 | 169060637 | + |
Frame-shift | ENST00000369040 | ENST00000359299 | ATE1 | chr10 | 123596233 | - | ANXA10 | chr4 | 169060637 | + |
Frame-shift | ENST00000369043 | ENST00000359299 | ATE1 | chr10 | 123596233 | - | ANXA10 | chr4 | 169060637 | + |
Frame-shift | ENST00000540606 | ENST00000359299 | ATE1 | chr10 | 123596233 | - | ANXA10 | chr4 | 169060637 | + |
In-frame | ENST00000535655 | ENST00000359299 | ATE1 | chr10 | 123596233 | - | ANXA10 | chr4 | 169060637 | + |
In-frame | ENST00000543447 | ENST00000359299 | ATE1 | chr10 | 123596233 | - | ANXA10 | chr4 | 169060637 | + |
intron-3CDS | ENST00000481784 | ENST00000359299 | ATE1 | chr10 | 123596233 | - | ANXA10 | chr4 | 169060637 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000535655 | ATE1 | chr10 | 123596233 | - | ENST00000359299 | ANXA10 | chr4 | 169060637 | + | 2444 | 1313 | 1327 | 2187 | 286 |
ENST00000543447 | ATE1 | chr10 | 123596233 | - | ENST00000359299 | ANXA10 | chr4 | 169060637 | + | 2236 | 1105 | 193 | 1125 | 310 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000535655 | ENST00000359299 | ATE1 | chr10 | 123596233 | - | ANXA10 | chr4 | 169060637 | + | 0.000700713 | 0.9992993 |
ENST00000543447 | ENST00000359299 | ATE1 | chr10 | 123596233 | - | ANXA10 | chr4 | 169060637 | + | 0.000797785 | 0.9992022 |
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Fusion Genomic Features for ATE1-ANXA10 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
ATE1 | chr10 | 123596232 | - | ANXA10 | chr4 | 169060636 | + | 6.92E-09 | 1 |
ATE1 | chr10 | 123596232 | - | ANXA10 | chr4 | 169060636 | + | 6.92E-09 | 1 |
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Fusion Protein Features for ATE1-ANXA10 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:123596233/chr4:169060637) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ATE1 | . |
FUNCTION: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | ANXA10 | chr10:123596233 | chr4:169060637 | ENST00000359299 | 1 | 12 | 171_243 | 33 | 325.0 | Repeat | Annexin 3 | |
Tgene | ANXA10 | chr10:123596233 | chr4:169060637 | ENST00000359299 | 1 | 12 | 247_318 | 33 | 325.0 | Repeat | Annexin 4 | |
Tgene | ANXA10 | chr10:123596233 | chr4:169060637 | ENST00000359299 | 1 | 12 | 89_160 | 33 | 325.0 | Repeat | Annexin 2 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | ANXA10 | chr10:123596233 | chr4:169060637 | ENST00000359299 | 1 | 12 | 17_88 | 33 | 325.0 | Repeat | Annexin 1 |
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Fusion Gene Sequence for ATE1-ANXA10 |
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>7390_7390_1_ATE1-ANXA10_ATE1_chr10_123596233_ENST00000535655_ANXA10_chr4_169060637_ENST00000359299_length(transcript)=2444nt_BP=1313nt ACCTGCTTGTGTTCTTGTATTCAGGGCACTGGAGTGCGTGCCAGCTGGTCTGGAAGCAGCTCCAGCAAGTCACTTACACGGTGGCCAGGG GCGGCCTGACTTTCAATCCGAGACCCGCCGGGAATGACTTTGGGATAATCACAACCTCCGGTCCTCAGTTTCCTTACCTGTGAAATGGGG CTGATAACGCACAGCTGTGGGAAGCACCGGCCCAAACGCAGGGCTTGGGGACACGACCACCATCCCCGCCCACGGGTCCCCGCGCCAGGC TTCGCTCTCCACCCCTCCCGCCGCGGGCCCCAGCGCTTCGCCGAGGTCGGCCCCGGGCGCCAAGAGGCGTGGTCGGCCCGAGCGGACCCT CGCGGCGGCCATGGCGTCGGTGGTGGAATACAAGGGCCTCAGGGCCGGCTACCACTGCGGCTACTGCGATTCCAAGGAGGGCAAAGCGTC CTGCGGCATGTGGGCACATTCCATGACAGTACAGGATTATCAGGATCTCATAGACCGAGGATGGCGAAGGTGCCGACCTTTACAATTTCA GCCTTCAAAATCTCACAAGAAGGTTTTGAAAAAAATGTTGAAATTTCTAGCTAAAGGGGAGGTTCCCAAAGGAAGTTGTGAGGATGAGCC CATGGATTCCACAATGGATGATGCTGTTGCGGGTGACTTTGCATTGATAAATAAACTGGATATACAGTGTGATCTTAAAACACTCAGTGA TGACATCAAAGAGAGTTTAGAGAGTGAAGGAAAAAATTCAAAGAAAGAAGAACCTCAGGAATTACTTCAGTCACAAGATTTCGTAGGAGA GAAGTTGGGCTCTGGTGAACCGTCACATTCAGTTAAAGTTCACACAGTTCCTAAGCCAGGTGAGGGTGGTGAGATCATCTCCACCAAGTT CGCAGTTCAAAGCCACACTTCTGGAGTCTTACCAGGTCTATAAACGTTACCAGATGGTTATTCACAAGAACCCACCTGATACGCCAACCG AAAGCCAGTTCACAAGATTCCTTTGCAGTTCACCCTTGGAGGCAGAGACTCCCCCTAATGGGCCAGATTGTGGCTATGGCTCCTTTCACC AGCAGTACTGGCTTGACGGAAAGATCATTGCTGTGGGGGTGATTGACATCCTCCCAAACTGTGTATCATCTGTGTATTTGTACTACGATC CTGATTATTCGTTTTTGTCTTTGGGCGTCTACTCTGCACTACGAGAAATTGCTTTTACTAGGCAGCTTCATGAGAAAACTTCTCAACTCA GCTATTATTATATGGGTTTCTACATTCATTCATGTCCCAAGATGAAATATAAGACTGTGACAAAGACATGCTGATCAACATTCTGACTCA GCGCTGCAATGCACAAAGGATGATGATTGCAGAGGCATACCAGAGCATGTATGGCCGGGACCTGATTGGGGATATGAGGGAGCAGCTTTC GGATCACTTCAAAGATGTGATGGCTGGCCTCATGTACCCACCACCACTGTATGATGCTCATGAGCTCTGGCATGCCATGAAGGGAGTAGG CACTGATGAGAATTGCCTCATTGAAATACTAGCTTCAAGAACAAATGGAGAAATTTTCCAGATGCGAGAAGCCTACTGCTTGCAATACAG CAATAACCTCCAAGAGGACATTTATTCAGAGACCTCAGGACACTTCAGAGATACTCTCATGAACTTGGTCCAGGGGACCAGAGAGGAAGG ATATACAGACCCTGCGATGGCTGCTCAGGATGCAATGGTCCTATGGGAAGCCTGTCAGCAGAAGACGGGGGAGCACAAAACCATGCTGCA AATGATCCTGTGCAACAAGAGCTACCAGCAGCTGCGGCTGGTTTTCCAGGAATTTCAAAATATTTCTGGGCAAGATATGGTAGATGCCAT TAATGAATGTTATGATGGATACTTTCAGGAGCTGCTGGTTGCAATTGTTCTCTGTGTTCGAGACAAACCAGCCTATTTTGCTTATAGATT ATATAGTGCAATTCATGACTTTGGTTTCCATAATAAAACTGTAATCAGGATTCTCATTGCCAGAAGTGAAATAGACCTGCTGACCATAAG GAAACGATACAAAGAGCGATATGGAAAATCCCTATTTCATGATATCAGAAATTTTGCTTCAGGGCATTATAAGAAAGCACTGCTTGCCAT CTGTGCTGGTGATGCTGAGGACTACTAAAATGAAGAGGACTTGGAGTACTGTGCACTCCTCTTTCTAGACACTTCCAAATAGAGATTTTC TCACAAATTTGTACTGTTCATGGCACTATTAACAAAACTATACAATCATATTTTCTCTTCTATCTTTGAAATTATTCTAAGCCAAAGAAA ACTATGAATGAAAGTATATGATACTGAATTTGCCTACTATCCTGAATTTGCCTACTATCTAATCAGCAATTAAATAAATTGTGCATGATG >7390_7390_1_ATE1-ANXA10_ATE1_chr10_123596233_ENST00000535655_ANXA10_chr4_169060637_ENST00000359299_length(amino acids)=286AA_BP= MLINILTQRCNAQRMMIAEAYQSMYGRDLIGDMREQLSDHFKDVMAGLMYPPPLYDAHELWHAMKGVGTDENCLIEILASRTNGEIFQMR EAYCLQYSNNLQEDIYSETSGHFRDTLMNLVQGTREEGYTDPAMAAQDAMVLWEACQQKTGEHKTMLQMILCNKSYQQLRLVFQEFQNIS GQDMVDAINECYDGYFQELLVAIVLCVRDKPAYFAYRLYSAIHDFGFHNKTVIRILIARSEIDLLTIRKRYKERYGKSLFHDIRNFASGH -------------------------------------------------------------- >7390_7390_2_ATE1-ANXA10_ATE1_chr10_123596233_ENST00000543447_ANXA10_chr4_169060637_ENST00000359299_length(transcript)=2236nt_BP=1105nt AGCGAGGACTTCTACCGCTGCGGCTACTGCAAGAACGAGTCGGGCAGCCGCTCCAATGGCATGTGGGCACATTCCATGACAGTACAGGAT TATCAGGATCTCATAGACCGAGGATGGCGAAGAAGTGGAAAATATGTGTACAAACCTGTCATGAATCAAACATGTTGTCCTCAGTACACA ATAAGATGAGCCCATGGATTCCACAATGGATGATGCTGTTGCGGGTGACTTTGCATTGATAAATAAACTGGATATACAGTGTGATCTTAA AACACTCAGTGATGACATCAAAGAGAGTTTAGAGAGTGAAGGAAAAAATTCAAAGAAAGAAGAACCTCAGGAATTACTTCAGTCACAAGA TTTCGTAGGAGAGAAGTTGGGCTCTGGTGAACCGTCACATTCAGTTAAAGTTCACACAGTTCCTAAGCCAGGCAAAGGGGCTGATTTGAG TAAGCCTCCATGTCGAAAAGCAAAGGAAATCCGGAAAGAAAGGAAAAGGTTAAAACTAATGCAGCAGAACCCAGCTGGAGAACTTGAGGG TTTCCAGGCTCAAGGTCACCCACCATCTTTGTTTCCACCAAAGGCTAAATCCAACCAGCCAAAATCACTCGAAGATTTAATTTTTGAGTC TTTACCAGAGAATGCATCACACAAGTTAGAGGTGAGGGTGGTGAGATCATCTCCACCAAGTTCGCAGTTCAAAGCCACACTTCTGGAGTC TTACCAGGTCTATAAACGTTACCAGATGGTTATTCACAAGAACCCACCTGATACGCCAACCGAAAGCCAGTTCACAAGATTCCTTTGCAG TTCACCCTTGGAGGCAGAGACTCCCCCTAATGGGCCAGATTGTGGCTATGGCTCCTTTCACCAGCAGTACTGGCTTGACGGAAAGATCAT TGCTGTGGGGGTGATTGACATCCTCCCAAACTGTGTATCATCTGTGTATTTGTACTACGATCCTGATTATTCGTTTTTGTCTTTGGGCGT CTACTCTGCACTACGAGAAATTGCTTTTACTAGGCAGCTTCATGAGAAAACTTCTCAACTCAGCTATTATTATATGGGTTTCTACATTCA TTCATGTCCCAAGATGAAATATAAGACTGTGACAAAGACATGCTGATCAACATTCTGACTCAGCGCTGCAATGCACAAAGGATGATGATT GCAGAGGCATACCAGAGCATGTATGGCCGGGACCTGATTGGGGATATGAGGGAGCAGCTTTCGGATCACTTCAAAGATGTGATGGCTGGC CTCATGTACCCACCACCACTGTATGATGCTCATGAGCTCTGGCATGCCATGAAGGGAGTAGGCACTGATGAGAATTGCCTCATTGAAATA CTAGCTTCAAGAACAAATGGAGAAATTTTCCAGATGCGAGAAGCCTACTGCTTGCAATACAGCAATAACCTCCAAGAGGACATTTATTCA GAGACCTCAGGACACTTCAGAGATACTCTCATGAACTTGGTCCAGGGGACCAGAGAGGAAGGATATACAGACCCTGCGATGGCTGCTCAG GATGCAATGGTCCTATGGGAAGCCTGTCAGCAGAAGACGGGGGAGCACAAAACCATGCTGCAAATGATCCTGTGCAACAAGAGCTACCAG CAGCTGCGGCTGGTTTTCCAGGAATTTCAAAATATTTCTGGGCAAGATATGGTAGATGCCATTAATGAATGTTATGATGGATACTTTCAG GAGCTGCTGGTTGCAATTGTTCTCTGTGTTCGAGACAAACCAGCCTATTTTGCTTATAGATTATATAGTGCAATTCATGACTTTGGTTTC CATAATAAAACTGTAATCAGGATTCTCATTGCCAGAAGTGAAATAGACCTGCTGACCATAAGGAAACGATACAAAGAGCGATATGGAAAA TCCCTATTTCATGATATCAGAAATTTTGCTTCAGGGCATTATAAGAAAGCACTGCTTGCCATCTGTGCTGGTGATGCTGAGGACTACTAA AATGAAGAGGACTTGGAGTACTGTGCACTCCTCTTTCTAGACACTTCCAAATAGAGATTTTCTCACAAATTTGTACTGTTCATGGCACTA TTAACAAAACTATACAATCATATTTTCTCTTCTATCTTTGAAATTATTCTAAGCCAAAGAAAACTATGAATGAAAGTATATGATACTGAA >7390_7390_2_ATE1-ANXA10_ATE1_chr10_123596233_ENST00000543447_ANXA10_chr4_169060637_ENST00000359299_length(amino acids)=310AA_BP= MDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPC RKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRVVRSSPPSSQFKATLLESYQVY KRYQMVIHKNPPDTPTESQFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSAL 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Fusion Gene PPI Analysis for ATE1-ANXA10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ATE1-ANXA10 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ATE1-ANXA10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0030297 | Pancreatic Neoplasm | 1 | CTD_human | |
Tgene | C0346647 | Malignant neoplasm of pancreas | 1 | CTD_human |