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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATE1-ANXA10 (FusionGDB2 ID:HG11101TG11199)

Fusion Gene Summary for ATE1-ANXA10

check button Fusion gene summary
Fusion gene informationFusion gene name: ATE1-ANXA10
Fusion gene ID: hg11101tg11199
HgeneTgene
Gene symbol

ATE1

ANXA10

Gene ID

11101

11199

Gene namearginyltransferase 1annexin A10
Synonyms-ANX14
Cytomap('ATE1')('ANXA10')

10q26.13

4q32.3

Type of geneprotein-codingprotein-coding
Descriptionarginyl-tRNA--protein transferase 1R-transferase 1arginine-tRNA--protein transferase 1arginyl-tRNA-protein transferaseannexin A10annexin 14annexin-10
Modification date2020031320200327
UniProtAcc

O95260

.
Ensembl transtripts involved in fusion geneENST00000224652, ENST00000369040, 
ENST00000369043, ENST00000540606, 
ENST00000535655, ENST00000543447, 
ENST00000481784, 
Fusion gene scores* DoF score7 X 8 X 7=3925 X 4 X 5=100
# samples 95
** MAII scorelog2(9/392*10)=-2.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATE1 [Title/Abstract] AND ANXA10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATE1(123596233)-ANXA10(169060637), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ATE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ANXA10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AD-6899-01AATE1chr10

123596233

-ANXA10chr4

169060637

+


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Fusion Gene ORF analysis for ATE1-ANXA10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000224652ENST00000359299ATE1chr10

123596233

-ANXA10chr4

169060637

+
Frame-shiftENST00000369040ENST00000359299ATE1chr10

123596233

-ANXA10chr4

169060637

+
Frame-shiftENST00000369043ENST00000359299ATE1chr10

123596233

-ANXA10chr4

169060637

+
Frame-shiftENST00000540606ENST00000359299ATE1chr10

123596233

-ANXA10chr4

169060637

+
In-frameENST00000535655ENST00000359299ATE1chr10

123596233

-ANXA10chr4

169060637

+
In-frameENST00000543447ENST00000359299ATE1chr10

123596233

-ANXA10chr4

169060637

+
intron-3CDSENST00000481784ENST00000359299ATE1chr10

123596233

-ANXA10chr4

169060637

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000535655ATE1chr10123596233-ENST00000359299ANXA10chr4169060637+2444131313272187286
ENST00000543447ATE1chr10123596233-ENST00000359299ANXA10chr4169060637+223611051931125310

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000535655ENST00000359299ATE1chr10123596233-ANXA10chr4169060637+0.0007007130.9992993
ENST00000543447ENST00000359299ATE1chr10123596233-ANXA10chr4169060637+0.0007977850.9992022

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Fusion Genomic Features for ATE1-ANXA10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATE1chr10123596232-ANXA10chr4169060636+6.92E-091
ATE1chr10123596232-ANXA10chr4169060636+6.92E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATE1-ANXA10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:123596233/chr4:169060637)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATE1

O95260

.
FUNCTION: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANXA10chr10:123596233chr4:169060637ENST00000359299112171_24333325.0RepeatAnnexin 3
TgeneANXA10chr10:123596233chr4:169060637ENST00000359299112247_31833325.0RepeatAnnexin 4
TgeneANXA10chr10:123596233chr4:169060637ENST0000035929911289_16033325.0RepeatAnnexin 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANXA10chr10:123596233chr4:169060637ENST0000035929911217_8833325.0RepeatAnnexin 1


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Fusion Gene Sequence for ATE1-ANXA10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7390_7390_1_ATE1-ANXA10_ATE1_chr10_123596233_ENST00000535655_ANXA10_chr4_169060637_ENST00000359299_length(transcript)=2444nt_BP=1313nt
ACCTGCTTGTGTTCTTGTATTCAGGGCACTGGAGTGCGTGCCAGCTGGTCTGGAAGCAGCTCCAGCAAGTCACTTACACGGTGGCCAGGG
GCGGCCTGACTTTCAATCCGAGACCCGCCGGGAATGACTTTGGGATAATCACAACCTCCGGTCCTCAGTTTCCTTACCTGTGAAATGGGG
CTGATAACGCACAGCTGTGGGAAGCACCGGCCCAAACGCAGGGCTTGGGGACACGACCACCATCCCCGCCCACGGGTCCCCGCGCCAGGC
TTCGCTCTCCACCCCTCCCGCCGCGGGCCCCAGCGCTTCGCCGAGGTCGGCCCCGGGCGCCAAGAGGCGTGGTCGGCCCGAGCGGACCCT
CGCGGCGGCCATGGCGTCGGTGGTGGAATACAAGGGCCTCAGGGCCGGCTACCACTGCGGCTACTGCGATTCCAAGGAGGGCAAAGCGTC
CTGCGGCATGTGGGCACATTCCATGACAGTACAGGATTATCAGGATCTCATAGACCGAGGATGGCGAAGGTGCCGACCTTTACAATTTCA
GCCTTCAAAATCTCACAAGAAGGTTTTGAAAAAAATGTTGAAATTTCTAGCTAAAGGGGAGGTTCCCAAAGGAAGTTGTGAGGATGAGCC
CATGGATTCCACAATGGATGATGCTGTTGCGGGTGACTTTGCATTGATAAATAAACTGGATATACAGTGTGATCTTAAAACACTCAGTGA
TGACATCAAAGAGAGTTTAGAGAGTGAAGGAAAAAATTCAAAGAAAGAAGAACCTCAGGAATTACTTCAGTCACAAGATTTCGTAGGAGA
GAAGTTGGGCTCTGGTGAACCGTCACATTCAGTTAAAGTTCACACAGTTCCTAAGCCAGGTGAGGGTGGTGAGATCATCTCCACCAAGTT
CGCAGTTCAAAGCCACACTTCTGGAGTCTTACCAGGTCTATAAACGTTACCAGATGGTTATTCACAAGAACCCACCTGATACGCCAACCG
AAAGCCAGTTCACAAGATTCCTTTGCAGTTCACCCTTGGAGGCAGAGACTCCCCCTAATGGGCCAGATTGTGGCTATGGCTCCTTTCACC
AGCAGTACTGGCTTGACGGAAAGATCATTGCTGTGGGGGTGATTGACATCCTCCCAAACTGTGTATCATCTGTGTATTTGTACTACGATC
CTGATTATTCGTTTTTGTCTTTGGGCGTCTACTCTGCACTACGAGAAATTGCTTTTACTAGGCAGCTTCATGAGAAAACTTCTCAACTCA
GCTATTATTATATGGGTTTCTACATTCATTCATGTCCCAAGATGAAATATAAGACTGTGACAAAGACATGCTGATCAACATTCTGACTCA
GCGCTGCAATGCACAAAGGATGATGATTGCAGAGGCATACCAGAGCATGTATGGCCGGGACCTGATTGGGGATATGAGGGAGCAGCTTTC
GGATCACTTCAAAGATGTGATGGCTGGCCTCATGTACCCACCACCACTGTATGATGCTCATGAGCTCTGGCATGCCATGAAGGGAGTAGG
CACTGATGAGAATTGCCTCATTGAAATACTAGCTTCAAGAACAAATGGAGAAATTTTCCAGATGCGAGAAGCCTACTGCTTGCAATACAG
CAATAACCTCCAAGAGGACATTTATTCAGAGACCTCAGGACACTTCAGAGATACTCTCATGAACTTGGTCCAGGGGACCAGAGAGGAAGG
ATATACAGACCCTGCGATGGCTGCTCAGGATGCAATGGTCCTATGGGAAGCCTGTCAGCAGAAGACGGGGGAGCACAAAACCATGCTGCA
AATGATCCTGTGCAACAAGAGCTACCAGCAGCTGCGGCTGGTTTTCCAGGAATTTCAAAATATTTCTGGGCAAGATATGGTAGATGCCAT
TAATGAATGTTATGATGGATACTTTCAGGAGCTGCTGGTTGCAATTGTTCTCTGTGTTCGAGACAAACCAGCCTATTTTGCTTATAGATT
ATATAGTGCAATTCATGACTTTGGTTTCCATAATAAAACTGTAATCAGGATTCTCATTGCCAGAAGTGAAATAGACCTGCTGACCATAAG
GAAACGATACAAAGAGCGATATGGAAAATCCCTATTTCATGATATCAGAAATTTTGCTTCAGGGCATTATAAGAAAGCACTGCTTGCCAT
CTGTGCTGGTGATGCTGAGGACTACTAAAATGAAGAGGACTTGGAGTACTGTGCACTCCTCTTTCTAGACACTTCCAAATAGAGATTTTC
TCACAAATTTGTACTGTTCATGGCACTATTAACAAAACTATACAATCATATTTTCTCTTCTATCTTTGAAATTATTCTAAGCCAAAGAAA
ACTATGAATGAAAGTATATGATACTGAATTTGCCTACTATCCTGAATTTGCCTACTATCTAATCAGCAATTAAATAAATTGTGCATGATG

>7390_7390_1_ATE1-ANXA10_ATE1_chr10_123596233_ENST00000535655_ANXA10_chr4_169060637_ENST00000359299_length(amino acids)=286AA_BP=
MLINILTQRCNAQRMMIAEAYQSMYGRDLIGDMREQLSDHFKDVMAGLMYPPPLYDAHELWHAMKGVGTDENCLIEILASRTNGEIFQMR
EAYCLQYSNNLQEDIYSETSGHFRDTLMNLVQGTREEGYTDPAMAAQDAMVLWEACQQKTGEHKTMLQMILCNKSYQQLRLVFQEFQNIS
GQDMVDAINECYDGYFQELLVAIVLCVRDKPAYFAYRLYSAIHDFGFHNKTVIRILIARSEIDLLTIRKRYKERYGKSLFHDIRNFASGH

--------------------------------------------------------------
>7390_7390_2_ATE1-ANXA10_ATE1_chr10_123596233_ENST00000543447_ANXA10_chr4_169060637_ENST00000359299_length(transcript)=2236nt_BP=1105nt
AGCGAGGACTTCTACCGCTGCGGCTACTGCAAGAACGAGTCGGGCAGCCGCTCCAATGGCATGTGGGCACATTCCATGACAGTACAGGAT
TATCAGGATCTCATAGACCGAGGATGGCGAAGAAGTGGAAAATATGTGTACAAACCTGTCATGAATCAAACATGTTGTCCTCAGTACACA
ATAAGATGAGCCCATGGATTCCACAATGGATGATGCTGTTGCGGGTGACTTTGCATTGATAAATAAACTGGATATACAGTGTGATCTTAA
AACACTCAGTGATGACATCAAAGAGAGTTTAGAGAGTGAAGGAAAAAATTCAAAGAAAGAAGAACCTCAGGAATTACTTCAGTCACAAGA
TTTCGTAGGAGAGAAGTTGGGCTCTGGTGAACCGTCACATTCAGTTAAAGTTCACACAGTTCCTAAGCCAGGCAAAGGGGCTGATTTGAG
TAAGCCTCCATGTCGAAAAGCAAAGGAAATCCGGAAAGAAAGGAAAAGGTTAAAACTAATGCAGCAGAACCCAGCTGGAGAACTTGAGGG
TTTCCAGGCTCAAGGTCACCCACCATCTTTGTTTCCACCAAAGGCTAAATCCAACCAGCCAAAATCACTCGAAGATTTAATTTTTGAGTC
TTTACCAGAGAATGCATCACACAAGTTAGAGGTGAGGGTGGTGAGATCATCTCCACCAAGTTCGCAGTTCAAAGCCACACTTCTGGAGTC
TTACCAGGTCTATAAACGTTACCAGATGGTTATTCACAAGAACCCACCTGATACGCCAACCGAAAGCCAGTTCACAAGATTCCTTTGCAG
TTCACCCTTGGAGGCAGAGACTCCCCCTAATGGGCCAGATTGTGGCTATGGCTCCTTTCACCAGCAGTACTGGCTTGACGGAAAGATCAT
TGCTGTGGGGGTGATTGACATCCTCCCAAACTGTGTATCATCTGTGTATTTGTACTACGATCCTGATTATTCGTTTTTGTCTTTGGGCGT
CTACTCTGCACTACGAGAAATTGCTTTTACTAGGCAGCTTCATGAGAAAACTTCTCAACTCAGCTATTATTATATGGGTTTCTACATTCA
TTCATGTCCCAAGATGAAATATAAGACTGTGACAAAGACATGCTGATCAACATTCTGACTCAGCGCTGCAATGCACAAAGGATGATGATT
GCAGAGGCATACCAGAGCATGTATGGCCGGGACCTGATTGGGGATATGAGGGAGCAGCTTTCGGATCACTTCAAAGATGTGATGGCTGGC
CTCATGTACCCACCACCACTGTATGATGCTCATGAGCTCTGGCATGCCATGAAGGGAGTAGGCACTGATGAGAATTGCCTCATTGAAATA
CTAGCTTCAAGAACAAATGGAGAAATTTTCCAGATGCGAGAAGCCTACTGCTTGCAATACAGCAATAACCTCCAAGAGGACATTTATTCA
GAGACCTCAGGACACTTCAGAGATACTCTCATGAACTTGGTCCAGGGGACCAGAGAGGAAGGATATACAGACCCTGCGATGGCTGCTCAG
GATGCAATGGTCCTATGGGAAGCCTGTCAGCAGAAGACGGGGGAGCACAAAACCATGCTGCAAATGATCCTGTGCAACAAGAGCTACCAG
CAGCTGCGGCTGGTTTTCCAGGAATTTCAAAATATTTCTGGGCAAGATATGGTAGATGCCATTAATGAATGTTATGATGGATACTTTCAG
GAGCTGCTGGTTGCAATTGTTCTCTGTGTTCGAGACAAACCAGCCTATTTTGCTTATAGATTATATAGTGCAATTCATGACTTTGGTTTC
CATAATAAAACTGTAATCAGGATTCTCATTGCCAGAAGTGAAATAGACCTGCTGACCATAAGGAAACGATACAAAGAGCGATATGGAAAA
TCCCTATTTCATGATATCAGAAATTTTGCTTCAGGGCATTATAAGAAAGCACTGCTTGCCATCTGTGCTGGTGATGCTGAGGACTACTAA
AATGAAGAGGACTTGGAGTACTGTGCACTCCTCTTTCTAGACACTTCCAAATAGAGATTTTCTCACAAATTTGTACTGTTCATGGCACTA
TTAACAAAACTATACAATCATATTTTCTCTTCTATCTTTGAAATTATTCTAAGCCAAAGAAAACTATGAATGAAAGTATATGATACTGAA

>7390_7390_2_ATE1-ANXA10_ATE1_chr10_123596233_ENST00000543447_ANXA10_chr4_169060637_ENST00000359299_length(amino acids)=310AA_BP=
MDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPC
RKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRVVRSSPPSSQFKATLLESYQVY
KRYQMVIHKNPPDTPTESQFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSAL

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Fusion Gene PPI Analysis for ATE1-ANXA10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATE1-ANXA10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATE1-ANXA10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0030297Pancreatic Neoplasm1CTD_human
TgeneC0346647Malignant neoplasm of pancreas1CTD_human