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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FOXN3-CDKL1 (FusionGDB2 ID:HG1112TG8814)

Fusion Gene Summary for FOXN3-CDKL1

check button Fusion gene summary
Fusion gene informationFusion gene name: FOXN3-CDKL1
Fusion gene ID: hg1112tg8814
HgeneTgene
Gene symbol

FOXN3

CDKL1

Gene ID

1112

8814

Gene nameforkhead box N3cyclin dependent kinase like 1
SynonymsC14orf116|CHES1|PRO1635KKIALRE|P42
Cytomap('FOXN3')('CDKL1')

14q31.3-q32.11

14q21.3

Type of geneprotein-codingprotein-coding
Descriptionforkhead box protein N3checkpoint suppressor 1cyclin-dependent kinase-like 1cyclin-dependent kinase-like 1 (CDC2-related kinase)protein kinase p42 KKIALREserine/threonine protein kinase KKIALRE
Modification date2020031320200313
UniProtAcc.

Q00532

Ensembl transtripts involved in fusion geneENST00000261302, ENST00000345097, 
ENST00000555353, ENST00000557258, 
ENST00000555658, 
Fusion gene scores* DoF score21 X 18 X 8=30244 X 4 X 3=48
# samples 226
** MAII scorelog2(22/3024*10)=-3.78088271069641
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FOXN3 [Title/Abstract] AND CDKL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFOXN3(89878278)-CDKL1(50796899), # samples:3
Anticipated loss of major functional domain due to fusion event.FOXN3-CDKL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FOXN3-CDKL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FOXN3-CDKL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FOXN3-CDKL1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
FOXN3-CDKL1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FOXN3-CDKL1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFOXN3

GO:0045892

negative regulation of transcription, DNA-templated

16102918


check buttonFusion gene breakpoints across FOXN3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CDKL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-A6-5667-01AFOXN3chr14

89878278

-CDKL1chr14

50796899

-
ChimerDB4COADTCGA-A6-5667FOXN3chr14

89878277

-CDKL1chr14

50796899

-


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Fusion Gene ORF analysis for FOXN3-CDKL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000261302ENST00000216378FOXN3chr14

89878278

-CDKL1chr14

50796899

-
5CDS-intronENST00000261302ENST00000216378FOXN3chr14

89878277

-CDKL1chr14

50796899

-
5CDS-intronENST00000261302ENST00000356146FOXN3chr14

89878278

-CDKL1chr14

50796899

-
5CDS-intronENST00000261302ENST00000356146FOXN3chr14

89878277

-CDKL1chr14

50796899

-
5CDS-intronENST00000345097ENST00000216378FOXN3chr14

89878278

-CDKL1chr14

50796899

-
5CDS-intronENST00000345097ENST00000216378FOXN3chr14

89878277

-CDKL1chr14

50796899

-
5CDS-intronENST00000345097ENST00000356146FOXN3chr14

89878278

-CDKL1chr14

50796899

-
5CDS-intronENST00000345097ENST00000356146FOXN3chr14

89878277

-CDKL1chr14

50796899

-
5CDS-intronENST00000555353ENST00000216378FOXN3chr14

89878278

-CDKL1chr14

50796899

-
5CDS-intronENST00000555353ENST00000216378FOXN3chr14

89878277

-CDKL1chr14

50796899

-
5CDS-intronENST00000555353ENST00000356146FOXN3chr14

89878278

-CDKL1chr14

50796899

-
5CDS-intronENST00000555353ENST00000356146FOXN3chr14

89878277

-CDKL1chr14

50796899

-
5CDS-intronENST00000557258ENST00000216378FOXN3chr14

89878278

-CDKL1chr14

50796899

-
5CDS-intronENST00000557258ENST00000216378FOXN3chr14

89878277

-CDKL1chr14

50796899

-
5CDS-intronENST00000557258ENST00000356146FOXN3chr14

89878278

-CDKL1chr14

50796899

-
5CDS-intronENST00000557258ENST00000356146FOXN3chr14

89878277

-CDKL1chr14

50796899

-
Frame-shiftENST00000345097ENST00000395834FOXN3chr14

89878278

-CDKL1chr14

50796899

-
Frame-shiftENST00000345097ENST00000395834FOXN3chr14

89878277

-CDKL1chr14

50796899

-
Frame-shiftENST00000555353ENST00000395834FOXN3chr14

89878278

-CDKL1chr14

50796899

-
Frame-shiftENST00000555353ENST00000395834FOXN3chr14

89878277

-CDKL1chr14

50796899

-
In-frameENST00000261302ENST00000395834FOXN3chr14

89878278

-CDKL1chr14

50796899

-
In-frameENST00000261302ENST00000395834FOXN3chr14

89878277

-CDKL1chr14

50796899

-
In-frameENST00000557258ENST00000395834FOXN3chr14

89878278

-CDKL1chr14

50796899

-
In-frameENST00000557258ENST00000395834FOXN3chr14

89878277

-CDKL1chr14

50796899

-
intron-3CDSENST00000555658ENST00000395834FOXN3chr14

89878278

-CDKL1chr14

50796899

-
intron-3CDSENST00000555658ENST00000395834FOXN3chr14

89878277

-CDKL1chr14

50796899

-
intron-intronENST00000555658ENST00000216378FOXN3chr14

89878278

-CDKL1chr14

50796899

-
intron-intronENST00000555658ENST00000216378FOXN3chr14

89878277

-CDKL1chr14

50796899

-
intron-intronENST00000555658ENST00000356146FOXN3chr14

89878278

-CDKL1chr14

50796899

-
intron-intronENST00000555658ENST00000356146FOXN3chr14

89878277

-CDKL1chr14

50796899

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000261302FOXN3chr1489878278-ENST00000395834CDKL1chr1450796899-114955916666216
ENST00000557258FOXN3chr1489878278-ENST00000395834CDKL1chr1450796899-1389799256906216
ENST00000261302FOXN3chr1489878277-ENST00000395834CDKL1chr1450796899-114955916666216
ENST00000557258FOXN3chr1489878277-ENST00000395834CDKL1chr1450796899-1389799256906216

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261302ENST00000395834FOXN3chr1489878278-CDKL1chr1450796899-0.0031439250.9968561
ENST00000557258ENST00000395834FOXN3chr1489878278-CDKL1chr1450796899-0.0030891580.99691087
ENST00000261302ENST00000395834FOXN3chr1489878277-CDKL1chr1450796899-0.0031439250.9968561
ENST00000557258ENST00000395834FOXN3chr1489878277-CDKL1chr1450796899-0.0030891580.99691087

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Fusion Genomic Features for FOXN3-CDKL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FOXN3-CDKL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:89878278/chr14:50796899)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CDKL1

Q00532

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOXN3chr14:89878277chr14:50796899ENST00000261302-16113_204181491.0DNA bindingFork-head
HgeneFOXN3chr14:89878277chr14:50796899ENST00000345097-27113_204181491.0DNA bindingFork-head
HgeneFOXN3chr14:89878277chr14:50796899ENST00000555353-26113_204181469.0DNA bindingFork-head
HgeneFOXN3chr14:89878277chr14:50796899ENST00000557258-26113_204181469.0DNA bindingFork-head
HgeneFOXN3chr14:89878278chr14:50796899ENST00000261302-16113_204181491.0DNA bindingFork-head
HgeneFOXN3chr14:89878278chr14:50796899ENST00000345097-27113_204181491.0DNA bindingFork-head
HgeneFOXN3chr14:89878278chr14:50796899ENST00000555353-26113_204181469.0DNA bindingFork-head
HgeneFOXN3chr14:89878278chr14:50796899ENST00000557258-26113_204181469.0DNA bindingFork-head
TgeneCDKL1chr14:89878277chr14:50796899ENST00000395834795_288323359.0DomainProtein kinase
TgeneCDKL1chr14:89878278chr14:50796899ENST00000395834795_288323359.0DomainProtein kinase
TgeneCDKL1chr14:89878277chr14:50796899ENST000003958347946_52323359.0MotifNote=[NKR]KIAxRE
TgeneCDKL1chr14:89878278chr14:50796899ENST000003958347946_52323359.0MotifNote=[NKR]KIAxRE
TgeneCDKL1chr14:89878277chr14:50796899ENST000003958347911_19323359.0Nucleotide bindingATP
TgeneCDKL1chr14:89878278chr14:50796899ENST000003958347911_19323359.0Nucleotide bindingATP


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Fusion Gene Sequence for FOXN3-CDKL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31138_31138_1_FOXN3-CDKL1_FOXN3_chr14_89878277_ENST00000261302_CDKL1_chr14_50796899_ENST00000395834_length(transcript)=1149nt_BP=559nt
AGGAGCCTTCACGTAAATGGGTCCAGTCATGCCTCCCAGTAAGAAGCCAGAAAGCTCAGGAATTAGTGTCTCCAGTGGACTGAGTCAGTG
TTACGGGGGCAGCGGTTTCTCCAAGGCCCTTCAGGAAGACGATGACCTCGACTTTTCTCTGCCTGACATCCGATTAGAAGAGGGGGCCAT
GGAAGATGAAGAGCTGACCAACCTGAACTGGCTGCACGAGAGCAAGAACTTGCTGAAGAGCTTTGGGGAGTCGGTCCTCAGGAGTGTCAG
CCCCGTCCAGGACCTGGACGATGACACCCCCCCATCCCCTGCCCACTCTGACATGCCCTACGATGCCAGGCAGAACCCCAACTGCAAACC
CCCCTACTCCTTCAGCTGCCTCATATTTATGGCCATCGAGGACTCTCCAACCAAGCGCCTGCCAGTGAAGGATATCTACAACTGGATCTT
GGAACATTTTCCGTATTTTGCAAATGCACCTACTGGGTGGAAAAACTCAGTGAGACACAATTTATCATTGAATAAGTGTTTTAAGAAAGT
GGACAAAGAGAGGAGTCAGTTGCAGTACCTACCCCAGCTAACTGGCAGCAGCATCCTTCCAGCTTTGGATAATAAGAAGTACTACTGTGA
TACCAAGAAACTTAACTACCGTTTTCCAAACATTTAAAGGAGCTAGGAGACATGATTTTAAAAAAGGAATCAATAGATGCTTTGAAGAAA
ATAAAACTTATACAGTTGATTGAAAACAATTACAATGTTGAAAACACACCAGGAGAAAACATAAGCAAGAAACTGGGAGGCCAACTGGCA
AGATATGAAGGGAAATTCCAGATCCAGTCTTCCATGCTTGATGATGGTGTCCAGAAAAGAAAAAACCTGTTTGGAGTTGCACTTGTATTT
CAGTTTATGTAAGTAGCCGAACTTATGGACAGAATATGAACTGTCCCATACCTCTGGCAAAACTAGATGATATCAAAAAGATTTATGCTT
CAGTTGTACCACATGCCACACAAGAAAAATGAACCACAAAATGCCCATATATATTTCCTCGGATCTCTGTTGCCTGAGTCCTATCTCCTG

>31138_31138_1_FOXN3-CDKL1_FOXN3_chr14_89878277_ENST00000261302_CDKL1_chr14_50796899_ENST00000395834_length(amino acids)=216AA_BP=181
MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDL
DDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERS

--------------------------------------------------------------
>31138_31138_2_FOXN3-CDKL1_FOXN3_chr14_89878277_ENST00000557258_CDKL1_chr14_50796899_ENST00000395834_length(transcript)=1389nt_BP=799nt
GCGGGAGGACGCGCGGCGCGCCCGGCGGACGCCGCAGGTCCCATGCCGCGCCGCGACCCCCGCGCCCCTGCCGCCCGCGCCCGCGGCCGC
CCCCCGCCGCCCGCCGCCCCGGGCTCGCCGCGCCGCGCCCGCGCGTCCTTAGCGGGGCCACCGAGCGATGCCCGCCGGGCGCCCGCGAAA
GTTTGTCGGCTCCTGCTGAAGGGCAGCGGCGCCCCCGCACCCCCGTGCCCCGCTCCGGCCAGGAGCCTTCACGTAAATGGGTCCAGTCAT
GCCTCCCAGTAAGAAGCCAGAAAGCTCAGGAATTAGTGTCTCCAGTGGACTGAGTCAGTGTTACGGGGGCAGCGGTTTCTCCAAGGCCCT
TCAGGAAGACGATGACCTCGACTTTTCTCTGCCTGACATCCGATTAGAAGAGGGGGCCATGGAAGATGAAGAGCTGACCAACCTGAACTG
GCTGCACGAGAGCAAGAACTTGCTGAAGAGCTTTGGGGAGTCGGTCCTCAGGAGTGTCAGCCCCGTCCAGGACCTGGACGATGACACCCC
CCCATCCCCTGCCCACTCTGACATGCCCTACGATGCCAGGCAGAACCCCAACTGCAAACCCCCCTACTCCTTCAGCTGCCTCATATTTAT
GGCCATCGAGGACTCTCCAACCAAGCGCCTGCCAGTGAAGGATATCTACAACTGGATCTTGGAACATTTTCCGTATTTTGCAAATGCACC
TACTGGGTGGAAAAACTCAGTGAGACACAATTTATCATTGAATAAGTGTTTTAAGAAAGTGGACAAAGAGAGGAGTCAGTTGCAGTACCT
ACCCCAGCTAACTGGCAGCAGCATCCTTCCAGCTTTGGATAATAAGAAGTACTACTGTGATACCAAGAAACTTAACTACCGTTTTCCAAA
CATTTAAAGGAGCTAGGAGACATGATTTTAAAAAAGGAATCAATAGATGCTTTGAAGAAAATAAAACTTATACAGTTGATTGAAAACAAT
TACAATGTTGAAAACACACCAGGAGAAAACATAAGCAAGAAACTGGGAGGCCAACTGGCAAGATATGAAGGGAAATTCCAGATCCAGTCT
TCCATGCTTGATGATGGTGTCCAGAAAAGAAAAAACCTGTTTGGAGTTGCACTTGTATTTCAGTTTATGTAAGTAGCCGAACTTATGGAC
AGAATATGAACTGTCCCATACCTCTGGCAAAACTAGATGATATCAAAAAGATTTATGCTTCAGTTGTACCACATGCCACACAAGAAAAAT
GAACCACAAAATGCCCATATATATTTCCTCGGATCTCTGTTGCCTGAGTCCTATCTCCTGCCTCTCAGATTGTTTCAGCATCATATTTAA

>31138_31138_2_FOXN3-CDKL1_FOXN3_chr14_89878277_ENST00000557258_CDKL1_chr14_50796899_ENST00000395834_length(amino acids)=216AA_BP=181
MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDL
DDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERS

--------------------------------------------------------------
>31138_31138_3_FOXN3-CDKL1_FOXN3_chr14_89878278_ENST00000261302_CDKL1_chr14_50796899_ENST00000395834_length(transcript)=1149nt_BP=559nt
AGGAGCCTTCACGTAAATGGGTCCAGTCATGCCTCCCAGTAAGAAGCCAGAAAGCTCAGGAATTAGTGTCTCCAGTGGACTGAGTCAGTG
TTACGGGGGCAGCGGTTTCTCCAAGGCCCTTCAGGAAGACGATGACCTCGACTTTTCTCTGCCTGACATCCGATTAGAAGAGGGGGCCAT
GGAAGATGAAGAGCTGACCAACCTGAACTGGCTGCACGAGAGCAAGAACTTGCTGAAGAGCTTTGGGGAGTCGGTCCTCAGGAGTGTCAG
CCCCGTCCAGGACCTGGACGATGACACCCCCCCATCCCCTGCCCACTCTGACATGCCCTACGATGCCAGGCAGAACCCCAACTGCAAACC
CCCCTACTCCTTCAGCTGCCTCATATTTATGGCCATCGAGGACTCTCCAACCAAGCGCCTGCCAGTGAAGGATATCTACAACTGGATCTT
GGAACATTTTCCGTATTTTGCAAATGCACCTACTGGGTGGAAAAACTCAGTGAGACACAATTTATCATTGAATAAGTGTTTTAAGAAAGT
GGACAAAGAGAGGAGTCAGTTGCAGTACCTACCCCAGCTAACTGGCAGCAGCATCCTTCCAGCTTTGGATAATAAGAAGTACTACTGTGA
TACCAAGAAACTTAACTACCGTTTTCCAAACATTTAAAGGAGCTAGGAGACATGATTTTAAAAAAGGAATCAATAGATGCTTTGAAGAAA
ATAAAACTTATACAGTTGATTGAAAACAATTACAATGTTGAAAACACACCAGGAGAAAACATAAGCAAGAAACTGGGAGGCCAACTGGCA
AGATATGAAGGGAAATTCCAGATCCAGTCTTCCATGCTTGATGATGGTGTCCAGAAAAGAAAAAACCTGTTTGGAGTTGCACTTGTATTT
CAGTTTATGTAAGTAGCCGAACTTATGGACAGAATATGAACTGTCCCATACCTCTGGCAAAACTAGATGATATCAAAAAGATTTATGCTT
CAGTTGTACCACATGCCACACAAGAAAAATGAACCACAAAATGCCCATATATATTTCCTCGGATCTCTGTTGCCTGAGTCCTATCTCCTG

>31138_31138_3_FOXN3-CDKL1_FOXN3_chr14_89878278_ENST00000261302_CDKL1_chr14_50796899_ENST00000395834_length(amino acids)=216AA_BP=181
MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDL
DDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERS

--------------------------------------------------------------
>31138_31138_4_FOXN3-CDKL1_FOXN3_chr14_89878278_ENST00000557258_CDKL1_chr14_50796899_ENST00000395834_length(transcript)=1389nt_BP=799nt
GCGGGAGGACGCGCGGCGCGCCCGGCGGACGCCGCAGGTCCCATGCCGCGCCGCGACCCCCGCGCCCCTGCCGCCCGCGCCCGCGGCCGC
CCCCCGCCGCCCGCCGCCCCGGGCTCGCCGCGCCGCGCCCGCGCGTCCTTAGCGGGGCCACCGAGCGATGCCCGCCGGGCGCCCGCGAAA
GTTTGTCGGCTCCTGCTGAAGGGCAGCGGCGCCCCCGCACCCCCGTGCCCCGCTCCGGCCAGGAGCCTTCACGTAAATGGGTCCAGTCAT
GCCTCCCAGTAAGAAGCCAGAAAGCTCAGGAATTAGTGTCTCCAGTGGACTGAGTCAGTGTTACGGGGGCAGCGGTTTCTCCAAGGCCCT
TCAGGAAGACGATGACCTCGACTTTTCTCTGCCTGACATCCGATTAGAAGAGGGGGCCATGGAAGATGAAGAGCTGACCAACCTGAACTG
GCTGCACGAGAGCAAGAACTTGCTGAAGAGCTTTGGGGAGTCGGTCCTCAGGAGTGTCAGCCCCGTCCAGGACCTGGACGATGACACCCC
CCCATCCCCTGCCCACTCTGACATGCCCTACGATGCCAGGCAGAACCCCAACTGCAAACCCCCCTACTCCTTCAGCTGCCTCATATTTAT
GGCCATCGAGGACTCTCCAACCAAGCGCCTGCCAGTGAAGGATATCTACAACTGGATCTTGGAACATTTTCCGTATTTTGCAAATGCACC
TACTGGGTGGAAAAACTCAGTGAGACACAATTTATCATTGAATAAGTGTTTTAAGAAAGTGGACAAAGAGAGGAGTCAGTTGCAGTACCT
ACCCCAGCTAACTGGCAGCAGCATCCTTCCAGCTTTGGATAATAAGAAGTACTACTGTGATACCAAGAAACTTAACTACCGTTTTCCAAA
CATTTAAAGGAGCTAGGAGACATGATTTTAAAAAAGGAATCAATAGATGCTTTGAAGAAAATAAAACTTATACAGTTGATTGAAAACAAT
TACAATGTTGAAAACACACCAGGAGAAAACATAAGCAAGAAACTGGGAGGCCAACTGGCAAGATATGAAGGGAAATTCCAGATCCAGTCT
TCCATGCTTGATGATGGTGTCCAGAAAAGAAAAAACCTGTTTGGAGTTGCACTTGTATTTCAGTTTATGTAAGTAGCCGAACTTATGGAC
AGAATATGAACTGTCCCATACCTCTGGCAAAACTAGATGATATCAAAAAGATTTATGCTTCAGTTGTACCACATGCCACACAAGAAAAAT
GAACCACAAAATGCCCATATATATTTCCTCGGATCTCTGTTGCCTGAGTCCTATCTCCTGCCTCTCAGATTGTTTCAGCATCATATTTAA

>31138_31138_4_FOXN3-CDKL1_FOXN3_chr14_89878278_ENST00000557258_CDKL1_chr14_50796899_ENST00000395834_length(amino acids)=216AA_BP=181
MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDL
DDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FOXN3-CDKL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FOXN3-CDKL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCDKL1Q00532DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for FOXN3-CDKL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource