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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FOXN3-SLC25A21 (FusionGDB2 ID:HG1112TG89874)

Fusion Gene Summary for FOXN3-SLC25A21

check button Fusion gene summary
Fusion gene informationFusion gene name: FOXN3-SLC25A21
Fusion gene ID: hg1112tg89874
HgeneTgene
Gene symbol

FOXN3

SLC25A21

Gene ID

1112

89874

Gene nameforkhead box N3solute carrier family 25 member 21
SynonymsC14orf116|CHES1|PRO1635MTDPS18|ODC|ODC1
Cytomap('FOXN3')('SLC25A21')

14q31.3-q32.11

14q13.3

Type of geneprotein-codingprotein-coding
Descriptionforkhead box protein N3checkpoint suppressor 1mitochondrial 2-oxodicarboxylate carrieroxodicarboxylate carriersolute carrier family 25 (mitochondrial oxoadipate carrier), member 21solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
Modification date2020031320200328
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000261302, ENST00000345097, 
ENST00000555353, ENST00000557258, 
ENST00000555658, 
Fusion gene scores* DoF score21 X 18 X 8=30249 X 5 X 6=270
# samples 2211
** MAII scorelog2(22/3024*10)=-3.78088271069641
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/270*10)=-1.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FOXN3 [Title/Abstract] AND SLC25A21 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFOXN3(89656728)-SLC25A21(37344209), # samples:3
Anticipated loss of major functional domain due to fusion event.FOXN3-SLC25A21 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FOXN3-SLC25A21 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FOXN3-SLC25A21 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FOXN3-SLC25A21 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FOXN3-SLC25A21 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FOXN3-SLC25A21 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
FOXN3-SLC25A21 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
FOXN3-SLC25A21 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFOXN3

GO:0045892

negative regulation of transcription, DNA-templated

16102918


check buttonFusion gene breakpoints across FOXN3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SLC25A21 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-44-7669-01AFOXN3chr14

89656728

-SLC25A21chr14

37344209

-
ChimerDB4LUADTCGA-44-7669-01AFOXN3chr14

89747294

-SLC25A21chr14

37344209

-


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Fusion Gene ORF analysis for FOXN3-SLC25A21

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000261302ENST00000557611FOXN3chr14

89656728

-SLC25A21chr14

37344209

-
5CDS-5UTRENST00000261302ENST00000557611FOXN3chr14

89747294

-SLC25A21chr14

37344209

-
5CDS-5UTRENST00000345097ENST00000557611FOXN3chr14

89656728

-SLC25A21chr14

37344209

-
5CDS-5UTRENST00000345097ENST00000557611FOXN3chr14

89747294

-SLC25A21chr14

37344209

-
5CDS-5UTRENST00000555353ENST00000557611FOXN3chr14

89747294

-SLC25A21chr14

37344209

-
5CDS-5UTRENST00000557258ENST00000557611FOXN3chr14

89747294

-SLC25A21chr14

37344209

-
5UTR-3CDSENST00000555658ENST00000331299FOXN3chr14

89747294

-SLC25A21chr14

37344209

-
5UTR-3CDSENST00000555658ENST00000555449FOXN3chr14

89747294

-SLC25A21chr14

37344209

-
5UTR-5UTRENST00000555658ENST00000557611FOXN3chr14

89747294

-SLC25A21chr14

37344209

-
Frame-shiftENST00000345097ENST00000331299FOXN3chr14

89656728

-SLC25A21chr14

37344209

-
Frame-shiftENST00000345097ENST00000331299FOXN3chr14

89747294

-SLC25A21chr14

37344209

-
Frame-shiftENST00000345097ENST00000555449FOXN3chr14

89656728

-SLC25A21chr14

37344209

-
Frame-shiftENST00000345097ENST00000555449FOXN3chr14

89747294

-SLC25A21chr14

37344209

-
Frame-shiftENST00000555353ENST00000331299FOXN3chr14

89747294

-SLC25A21chr14

37344209

-
Frame-shiftENST00000555353ENST00000555449FOXN3chr14

89747294

-SLC25A21chr14

37344209

-
In-frameENST00000261302ENST00000331299FOXN3chr14

89656728

-SLC25A21chr14

37344209

-
In-frameENST00000261302ENST00000331299FOXN3chr14

89747294

-SLC25A21chr14

37344209

-
In-frameENST00000261302ENST00000555449FOXN3chr14

89656728

-SLC25A21chr14

37344209

-
In-frameENST00000261302ENST00000555449FOXN3chr14

89747294

-SLC25A21chr14

37344209

-
In-frameENST00000557258ENST00000331299FOXN3chr14

89747294

-SLC25A21chr14

37344209

-
In-frameENST00000557258ENST00000555449FOXN3chr14

89747294

-SLC25A21chr14

37344209

-
intron-3CDSENST00000555353ENST00000331299FOXN3chr14

89656728

-SLC25A21chr14

37344209

-
intron-3CDSENST00000555353ENST00000555449FOXN3chr14

89656728

-SLC25A21chr14

37344209

-
intron-3CDSENST00000555658ENST00000331299FOXN3chr14

89656728

-SLC25A21chr14

37344209

-
intron-3CDSENST00000555658ENST00000555449FOXN3chr14

89656728

-SLC25A21chr14

37344209

-
intron-3CDSENST00000557258ENST00000331299FOXN3chr14

89656728

-SLC25A21chr14

37344209

-
intron-3CDSENST00000557258ENST00000555449FOXN3chr14

89656728

-SLC25A21chr14

37344209

-
intron-5UTRENST00000555353ENST00000557611FOXN3chr14

89656728

-SLC25A21chr14

37344209

-
intron-5UTRENST00000555658ENST00000557611FOXN3chr14

89656728

-SLC25A21chr14

37344209

-
intron-5UTRENST00000557258ENST00000557611FOXN3chr14

89656728

-SLC25A21chr14

37344209

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261302FOXN3chr1489656728-ENST00000555449SLC25A21chr1437344209-1707827161653545
ENST00000261302FOXN3chr1489656728-ENST00000331299SLC25A21chr1437344209-3026827161656546
ENST00000261302FOXN3chr1489747294-ENST00000555449SLC25A21chr1437344209-1641761161587523
ENST00000261302FOXN3chr1489747294-ENST00000331299SLC25A21chr1437344209-2960761161590524
ENST00000557258FOXN3chr1489747294-ENST00000555449SLC25A21chr1437344209-188110012561827523
ENST00000557258FOXN3chr1489747294-ENST00000331299SLC25A21chr1437344209-320010012561830524

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261302ENST00000555449FOXN3chr1489656728-SLC25A21chr1437344209-0.0017259540.9982741
ENST00000261302ENST00000331299FOXN3chr1489656728-SLC25A21chr1437344209-0.0002638620.99973613
ENST00000261302ENST00000555449FOXN3chr1489747294-SLC25A21chr1437344209-0.0016843460.9983157
ENST00000261302ENST00000331299FOXN3chr1489747294-SLC25A21chr1437344209-0.0002776240.9997223
ENST00000557258ENST00000555449FOXN3chr1489747294-SLC25A21chr1437344209-0.0022922250.9977077
ENST00000557258ENST00000331299FOXN3chr1489747294-SLC25A21chr1437344209-0.0003683370.99963164

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Fusion Genomic Features for FOXN3-SLC25A21


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FOXN3-SLC25A21


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:89656728/chr14:37344209)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOXN3chr14:89656728chr14:37344209ENST00000261302-46113_204270491.0DNA bindingFork-head
HgeneFOXN3chr14:89656728chr14:37344209ENST00000345097-57113_204270491.0DNA bindingFork-head
HgeneFOXN3chr14:89747294chr14:37344209ENST00000261302-36113_204248491.0DNA bindingFork-head
HgeneFOXN3chr14:89747294chr14:37344209ENST00000345097-47113_204248491.0DNA bindingFork-head
HgeneFOXN3chr14:89747294chr14:37344209ENST00000555353-46113_204248469.0DNA bindingFork-head
HgeneFOXN3chr14:89747294chr14:37344209ENST00000557258-46113_204248469.0DNA bindingFork-head
TgeneSLC25A21chr14:89656728chr14:37344209ENST00000331299010107_19623300.0RepeatNote=Solcar 2
TgeneSLC25A21chr14:89656728chr14:37344209ENST00000331299010205_29423300.0RepeatNote=Solcar 3
TgeneSLC25A21chr14:89656728chr14:37344209ENST00000555449011107_19623299.0RepeatNote=Solcar 2
TgeneSLC25A21chr14:89656728chr14:37344209ENST00000555449011205_29423299.0RepeatNote=Solcar 3
TgeneSLC25A21chr14:89747294chr14:37344209ENST00000331299010107_19623300.0RepeatNote=Solcar 2
TgeneSLC25A21chr14:89747294chr14:37344209ENST00000331299010205_29423300.0RepeatNote=Solcar 3
TgeneSLC25A21chr14:89747294chr14:37344209ENST00000555449011107_19623299.0RepeatNote=Solcar 2
TgeneSLC25A21chr14:89747294chr14:37344209ENST00000555449011205_29423299.0RepeatNote=Solcar 3
TgeneSLC25A21chr14:89656728chr14:37344209ENST00000331299010113_13323300.0TransmembraneHelical%3B Name%3D3
TgeneSLC25A21chr14:89656728chr14:37344209ENST00000331299010167_18723300.0TransmembraneHelical%3B Name%3D4
TgeneSLC25A21chr14:89656728chr14:37344209ENST00000331299010205_22523300.0TransmembraneHelical%3B Name%3D5
TgeneSLC25A21chr14:89656728chr14:37344209ENST00000331299010277_29723300.0TransmembraneHelical%3B Name%3D6
TgeneSLC25A21chr14:89656728chr14:37344209ENST0000033129901070_8923300.0TransmembraneHelical%3B Name%3D2
TgeneSLC25A21chr14:89656728chr14:37344209ENST00000555449011113_13323299.0TransmembraneHelical%3B Name%3D3
TgeneSLC25A21chr14:89656728chr14:37344209ENST00000555449011167_18723299.0TransmembraneHelical%3B Name%3D4
TgeneSLC25A21chr14:89656728chr14:37344209ENST00000555449011205_22523299.0TransmembraneHelical%3B Name%3D5
TgeneSLC25A21chr14:89656728chr14:37344209ENST00000555449011277_29723299.0TransmembraneHelical%3B Name%3D6
TgeneSLC25A21chr14:89656728chr14:37344209ENST0000055544901170_8923299.0TransmembraneHelical%3B Name%3D2
TgeneSLC25A21chr14:89747294chr14:37344209ENST00000331299010113_13323300.0TransmembraneHelical%3B Name%3D3
TgeneSLC25A21chr14:89747294chr14:37344209ENST00000331299010167_18723300.0TransmembraneHelical%3B Name%3D4
TgeneSLC25A21chr14:89747294chr14:37344209ENST00000331299010205_22523300.0TransmembraneHelical%3B Name%3D5
TgeneSLC25A21chr14:89747294chr14:37344209ENST00000331299010277_29723300.0TransmembraneHelical%3B Name%3D6
TgeneSLC25A21chr14:89747294chr14:37344209ENST0000033129901070_8923300.0TransmembraneHelical%3B Name%3D2
TgeneSLC25A21chr14:89747294chr14:37344209ENST00000555449011113_13323299.0TransmembraneHelical%3B Name%3D3
TgeneSLC25A21chr14:89747294chr14:37344209ENST00000555449011167_18723299.0TransmembraneHelical%3B Name%3D4
TgeneSLC25A21chr14:89747294chr14:37344209ENST00000555449011205_22523299.0TransmembraneHelical%3B Name%3D5
TgeneSLC25A21chr14:89747294chr14:37344209ENST00000555449011277_29723299.0TransmembraneHelical%3B Name%3D6
TgeneSLC25A21chr14:89747294chr14:37344209ENST0000055544901170_8923299.0TransmembraneHelical%3B Name%3D2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOXN3chr14:89656728chr14:37344209ENST00000555353-16113_2040469.0DNA bindingFork-head
HgeneFOXN3chr14:89656728chr14:37344209ENST00000557258-16113_2040469.0DNA bindingFork-head
TgeneSLC25A21chr14:89656728chr14:37344209ENST0000033129901011_10023300.0RepeatNote=Solcar 1
TgeneSLC25A21chr14:89656728chr14:37344209ENST0000055544901111_10023299.0RepeatNote=Solcar 1
TgeneSLC25A21chr14:89747294chr14:37344209ENST0000033129901011_10023300.0RepeatNote=Solcar 1
TgeneSLC25A21chr14:89747294chr14:37344209ENST0000055544901111_10023299.0RepeatNote=Solcar 1
TgeneSLC25A21chr14:89656728chr14:37344209ENST0000033129901017_3723300.0TransmembraneHelical%3B Name%3D1
TgeneSLC25A21chr14:89656728chr14:37344209ENST0000055544901117_3723299.0TransmembraneHelical%3B Name%3D1
TgeneSLC25A21chr14:89747294chr14:37344209ENST0000033129901017_3723300.0TransmembraneHelical%3B Name%3D1
TgeneSLC25A21chr14:89747294chr14:37344209ENST0000055544901117_3723299.0TransmembraneHelical%3B Name%3D1


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Fusion Gene Sequence for FOXN3-SLC25A21


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31152_31152_1_FOXN3-SLC25A21_FOXN3_chr14_89656728_ENST00000261302_SLC25A21_chr14_37344209_ENST00000331299_length(transcript)=3026nt_BP=827nt
AGGAGCCTTCACGTAAATGGGTCCAGTCATGCCTCCCAGTAAGAAGCCAGAAAGCTCAGGAATTAGTGTCTCCAGTGGACTGAGTCAGTG
TTACGGGGGCAGCGGTTTCTCCAAGGCCCTTCAGGAAGACGATGACCTCGACTTTTCTCTGCCTGACATCCGATTAGAAGAGGGGGCCAT
GGAAGATGAAGAGCTGACCAACCTGAACTGGCTGCACGAGAGCAAGAACTTGCTGAAGAGCTTTGGGGAGTCGGTCCTCAGGAGTGTCAG
CCCCGTCCAGGACCTGGACGATGACACCCCCCCATCCCCTGCCCACTCTGACATGCCCTACGATGCCAGGCAGAACCCCAACTGCAAACC
CCCCTACTCCTTCAGCTGCCTCATATTTATGGCCATCGAGGACTCTCCAACCAAGCGCCTGCCAGTGAAGGATATCTACAACTGGATCTT
GGAACATTTTCCGTATTTTGCAAATGCACCTACTGGGTGGAAAAACTCAGTGAGACACAATTTATCATTGAATAAGTGTTTTAAGAAAGT
GGACAAAGAGAGGAGTCAGAGTATTGGGAAAGGGTCGTTGTGGTGCATAGACCCAGAGTATAGACAAAATCTAATTCAGGCTTTGAAAAA
GACACCTTATCACCCACACCCACACGTGTTCAATACACCTCCCACCTGTCCTCAGGCATATCAAAGCACATCAGGTCCACCCATCTGGCC
GGGCAGTACCTTCTTCAAGAGAAATGGAGCCCTTCTCCAAGATCCTGACATTGATGCTGCCAGTGCCATGATGCTTTTGAATACTCCCCC
TGAGATACAAGCAGGTTGTCTTGTAGAAATTTGCCTGATGCACCCCCTAGATGTGGTGAAAACCAGGTTTCAGATTCAGAGATGTGCAAC
CGATCCAAACAGTTATAAAAGCTTGGTAGACAGCTTTCGAATGATTTTCCAAATGGAAGGGTTATTTGGTTTTTACAAGGGAATTCTGCC
ACCTATCTTGGCTGAAACCCCAAAAAGAGCAGTGAAGTTTTTCACCTTTGAGCAGTACAAGAAATTGCTGGGATATGTGTCACTGTCACC
AGCATTGACATTCGCCATTGCTGGATTGGGATCTGGACTAACAGAAGCCATTGTAGTTAACCCTTTTGAGGTAGTAAAAGTTGGCTTGCA
AGCAAATCGGAACACATTTGCAGAGCAACCATCCACTGTGGGTTATGCAAGACAAATCATTAAGAAGGAAGGCTGGGGACTCCAGGGCCT
CAACAAAGGATTAACTGCAACTTTGGGACGACATGGAGTTTTCAACATGGTTTATTTTGGCTTCTACTACAATGTCAAAAACATGATTCC
TGTCAATAAGGATCCAATCTTGGAGTTTTGGAGAAAATTTGGGATTGGTCTTCTCTCGGGGACAATAGCCTCAGTCATTAACATCCCTTT
TGATGTTGCCAAAAGTAGGATTCAAGGGCCTCAACCAGTTCCTGGAGAGATCAAGTACAGAACCTGTTTTAAAACAATGGCAACAGTCTA
TCAGGAAGAAGGGATTTTAGCTTTGTACAAAGGCCTGCTTCCCAAGATTATGAGACTTGGACCAGGTGGTGCAGTGATGCTGCTGGTTTA
TGAATACACCTATTCATGGCTTCAAGAGAACTGGTGATTGCCTATGAAGTGTTTTTCCCCCTTGAGATAATGGATATTTGCTATGCAGCA
CCATGAAGAAGAGAGACTATCGATCGGCCAGGTGTATAATTATGAAGGAGAAAACTGTTCAAGAACAAAATCTATTTTAATACTTTAAAA
AATGTCTATAGGCAACTTGAGATTATAGTTTTGGCTGTATAAATAAAACTGTGAGAAGAAAAAAATAATATGAAACAATGAGGTATTTAA
AGTGAATATAGAAAAATAGCATAGAAATCATATATTTATTTCATAAAATAAATAGAAACTTTGTCTCCTGTGTTCCTCTTCAATGCTTCA
CAATGAAAATTCATTGTATTGATCAGCATTTTTCCTAAGAGGTCTAGAAATGCTTAAACTATTGAAAATAAATCAAATTATTCAAAGACT
GGATTAAAAAAAAGTTAAGCCAAAATTTAAGCAGTTTTTATAATGAATTAAATTATTCCATAAATAATATTTAAAGAGCACAAGAAAAAT
TTTTTAAAGTGCACTAAAATGACCTTTTAAGAATGTTTAATTTTATGAATACTATGTTAAAATGTAAATCTGTTGGTTTTTTTTAGTAAC
TATGCACATATCAGCTCTATTTTCCTACATCTACTTTATATCTCATATTGCTGTAAGATAATAAATAGGTATTTTAAAACATTGTTTAAA
ACAGAATGTTAAAACACTGTTGTTTAAGCATGTTTAAATCAAGGTATTCCAAATCTCTTCTAACACAAGTAGGAAACATGAAATAAAATT
TACTTTCCTCCACATAGTTCTCTTTGAAGATAAGTTTTGTTGATGAGATATTGTCATGTTAAATCACAAATTGGAAACACCTTTGGACCC
ATTTGTCAGCCATCAGTATTTGCATCCAAATACCTTTATTCAGCATGCCTACCTGTGCCATTTTTAGGAAGAATGTATAGAACAGAACTG
CATTTTCAGGTTATTAGTTTTAAACGACAACTTCAGGTGGGAAGTCAGCTGTCTGCAGTATTAAAATATGTATGATGAAGGGGAAATGTT
CTGAAAAAGAAATACACTTAGCATTTCTAAGGATTACTATACTAACATGTATCAACAAAAATATCTCCTTGGTCTTGATGTAACCAAACT
TGATTTTATATCTGCATCCAGAGATGATGCTGATTCAGTAAAGTCAACAAGAATAACTGAAAGTCCATATGACACCTGTCCTAAGTTACT
ACCGTGGGCTATTTCTACTACGGGGCTATTTCACTAAAGCATTTTGAAAATAAAAAGTAAAAGATAACATGGTAATTATTACTTTTTATT
AATTTAGAGCATTTGAAGTATAAAAATAAAAGGCTTTTGACATACTGTATATACAT

>31152_31152_1_FOXN3-SLC25A21_FOXN3_chr14_89656728_ENST00000261302_SLC25A21_chr14_37344209_ENST00000331299_length(amino acids)=546AA_BP=271
MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDL
DDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERS
QSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQDPDIDAASAMMLLNTPPEIQAG
CLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFA
IAGLGSGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDP
ILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYS
WLQENW

--------------------------------------------------------------
>31152_31152_2_FOXN3-SLC25A21_FOXN3_chr14_89656728_ENST00000261302_SLC25A21_chr14_37344209_ENST00000555449_length(transcript)=1707nt_BP=827nt
AGGAGCCTTCACGTAAATGGGTCCAGTCATGCCTCCCAGTAAGAAGCCAGAAAGCTCAGGAATTAGTGTCTCCAGTGGACTGAGTCAGTG
TTACGGGGGCAGCGGTTTCTCCAAGGCCCTTCAGGAAGACGATGACCTCGACTTTTCTCTGCCTGACATCCGATTAGAAGAGGGGGCCAT
GGAAGATGAAGAGCTGACCAACCTGAACTGGCTGCACGAGAGCAAGAACTTGCTGAAGAGCTTTGGGGAGTCGGTCCTCAGGAGTGTCAG
CCCCGTCCAGGACCTGGACGATGACACCCCCCCATCCCCTGCCCACTCTGACATGCCCTACGATGCCAGGCAGAACCCCAACTGCAAACC
CCCCTACTCCTTCAGCTGCCTCATATTTATGGCCATCGAGGACTCTCCAACCAAGCGCCTGCCAGTGAAGGATATCTACAACTGGATCTT
GGAACATTTTCCGTATTTTGCAAATGCACCTACTGGGTGGAAAAACTCAGTGAGACACAATTTATCATTGAATAAGTGTTTTAAGAAAGT
GGACAAAGAGAGGAGTCAGAGTATTGGGAAAGGGTCGTTGTGGTGCATAGACCCAGAGTATAGACAAAATCTAATTCAGGCTTTGAAAAA
GACACCTTATCACCCACACCCACACGTGTTCAATACACCTCCCACCTGTCCTCAGGCATATCAAAGCACATCAGGTCCACCCATCTGGCC
GGGCAGTACCTTCTTCAAGAGAAATGGAGCCCTTCTCCAAGATCCTGACATTGATGCTGCCAGTGCCATGATGCTTTTGAATACTCCCCC
TGAGATACAAGCAGGTTGTCTTGTAGAAATTTGCCTGATGCACCCCCTAGATGTGGTGAAAACCAGGTTTCAGATTCAGAGATGTGCAAC
CGATCCAAACAGTTATAAAAGCTTGGTAGACAGCTTTCGAATGATTTTCCAAATGGAAGGGTTATTTGGTTTTTACAAGGGAATTCTGCC
ACCTATCTTGGCTGAAACCCCAAAAAGAGCAGTGAAGTTTTTCACCTTTGAGCAGTACAAGAAATTGCTGGGATATGTGTCACTGTCACC
AGCATTGACATTCGCCATTGCTGGATTGGGATCTGGACTAACAGAAGCCATTGTAGTTAACCCTTTTGAGGTAGTAAAAGTTGGCTTGCA
AGCAAATCGGAACACATTTGCAGAGCAACCATCCACTGTGGGTTATGCAAGACAAATCATTAAGAAGGAAGGCTGGGGACTCCAGGGCCT
CAACAAAGGATTAACTGCAACTTTGGGACGACATGGAGTTTTCAACATGGTTTATTTTGGCTTCTACTACAATGTCAAAAACATGATTCC
TGTCAATAAGGATCCAATCTTGGAGTTTTGGAGAAAATTTGGGATTGGTCTTCTCTCGGGGACAATAGCCTCAGTCATTAACATCCCTTT
TGATGTTGCCAAAAGTAGGATTCAAGGGCCTCAACCAGTTCCTGGAGAGATCAAGTACAGAACCTGTTTTAAAACAATGGCAACAGTCTA
TCAGGAAGAAGGGATTTTAGCTTTGTACAAAGGCCTGCTTCCCAAGATTATGAGACTTGGACCAGGTGGTGCAGTGATGCTGCTGGTTTA
TGAATACACCTATTCATGGCTTCAAGAGAACTGACTGGGAACTCCAGATGTCAATGGAAGTTTTACAAGATCAAAGGAAGACTATGG

>31152_31152_2_FOXN3-SLC25A21_FOXN3_chr14_89656728_ENST00000261302_SLC25A21_chr14_37344209_ENST00000555449_length(amino acids)=545AA_BP=271
MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDL
DDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERS
QSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQDPDIDAASAMMLLNTPPEIQAG
CLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFA
IAGLGSGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDP
ILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYS
WLQEN

--------------------------------------------------------------
>31152_31152_3_FOXN3-SLC25A21_FOXN3_chr14_89747294_ENST00000261302_SLC25A21_chr14_37344209_ENST00000331299_length(transcript)=2960nt_BP=761nt
AGGAGCCTTCACGTAAATGGGTCCAGTCATGCCTCCCAGTAAGAAGCCAGAAAGCTCAGGAATTAGTGTCTCCAGTGGACTGAGTCAGTG
TTACGGGGGCAGCGGTTTCTCCAAGGCCCTTCAGGAAGACGATGACCTCGACTTTTCTCTGCCTGACATCCGATTAGAAGAGGGGGCCAT
GGAAGATGAAGAGCTGACCAACCTGAACTGGCTGCACGAGAGCAAGAACTTGCTGAAGAGCTTTGGGGAGTCGGTCCTCAGGAGTGTCAG
CCCCGTCCAGGACCTGGACGATGACACCCCCCCATCCCCTGCCCACTCTGACATGCCCTACGATGCCAGGCAGAACCCCAACTGCAAACC
CCCCTACTCCTTCAGCTGCCTCATATTTATGGCCATCGAGGACTCTCCAACCAAGCGCCTGCCAGTGAAGGATATCTACAACTGGATCTT
GGAACATTTTCCGTATTTTGCAAATGCACCTACTGGGTGGAAAAACTCAGTGAGACACAATTTATCATTGAATAAGTGTTTTAAGAAAGT
GGACAAAGAGAGGAGTCAGAGTATTGGGAAAGGGTCGTTGTGGTGCATAGACCCAGAGTATAGACAAAATCTAATTCAGGCTTTGAAAAA
GACACCTTATCACCCACACCCACACGTGTTCAATACACCTCCCACCTGTCCTCAGGCATATCAAAGCACATCAGGTCCACCCATCTGGCC
GGGCAGTACCTTCTTCAAGAGAAATGGAGCCCTTCTCCAAGGTCTTGTAGAAATTTGCCTGATGCACCCCCTAGATGTGGTGAAAACCAG
GTTTCAGATTCAGAGATGTGCAACCGATCCAAACAGTTATAAAAGCTTGGTAGACAGCTTTCGAATGATTTTCCAAATGGAAGGGTTATT
TGGTTTTTACAAGGGAATTCTGCCACCTATCTTGGCTGAAACCCCAAAAAGAGCAGTGAAGTTTTTCACCTTTGAGCAGTACAAGAAATT
GCTGGGATATGTGTCACTGTCACCAGCATTGACATTCGCCATTGCTGGATTGGGATCTGGACTAACAGAAGCCATTGTAGTTAACCCTTT
TGAGGTAGTAAAAGTTGGCTTGCAAGCAAATCGGAACACATTTGCAGAGCAACCATCCACTGTGGGTTATGCAAGACAAATCATTAAGAA
GGAAGGCTGGGGACTCCAGGGCCTCAACAAAGGATTAACTGCAACTTTGGGACGACATGGAGTTTTCAACATGGTTTATTTTGGCTTCTA
CTACAATGTCAAAAACATGATTCCTGTCAATAAGGATCCAATCTTGGAGTTTTGGAGAAAATTTGGGATTGGTCTTCTCTCGGGGACAAT
AGCCTCAGTCATTAACATCCCTTTTGATGTTGCCAAAAGTAGGATTCAAGGGCCTCAACCAGTTCCTGGAGAGATCAAGTACAGAACCTG
TTTTAAAACAATGGCAACAGTCTATCAGGAAGAAGGGATTTTAGCTTTGTACAAAGGCCTGCTTCCCAAGATTATGAGACTTGGACCAGG
TGGTGCAGTGATGCTGCTGGTTTATGAATACACCTATTCATGGCTTCAAGAGAACTGGTGATTGCCTATGAAGTGTTTTTCCCCCTTGAG
ATAATGGATATTTGCTATGCAGCACCATGAAGAAGAGAGACTATCGATCGGCCAGGTGTATAATTATGAAGGAGAAAACTGTTCAAGAAC
AAAATCTATTTTAATACTTTAAAAAATGTCTATAGGCAACTTGAGATTATAGTTTTGGCTGTATAAATAAAACTGTGAGAAGAAAAAAAT
AATATGAAACAATGAGGTATTTAAAGTGAATATAGAAAAATAGCATAGAAATCATATATTTATTTCATAAAATAAATAGAAACTTTGTCT
CCTGTGTTCCTCTTCAATGCTTCACAATGAAAATTCATTGTATTGATCAGCATTTTTCCTAAGAGGTCTAGAAATGCTTAAACTATTGAA
AATAAATCAAATTATTCAAAGACTGGATTAAAAAAAAGTTAAGCCAAAATTTAAGCAGTTTTTATAATGAATTAAATTATTCCATAAATA
ATATTTAAAGAGCACAAGAAAAATTTTTTAAAGTGCACTAAAATGACCTTTTAAGAATGTTTAATTTTATGAATACTATGTTAAAATGTA
AATCTGTTGGTTTTTTTTAGTAACTATGCACATATCAGCTCTATTTTCCTACATCTACTTTATATCTCATATTGCTGTAAGATAATAAAT
AGGTATTTTAAAACATTGTTTAAAACAGAATGTTAAAACACTGTTGTTTAAGCATGTTTAAATCAAGGTATTCCAAATCTCTTCTAACAC
AAGTAGGAAACATGAAATAAAATTTACTTTCCTCCACATAGTTCTCTTTGAAGATAAGTTTTGTTGATGAGATATTGTCATGTTAAATCA
CAAATTGGAAACACCTTTGGACCCATTTGTCAGCCATCAGTATTTGCATCCAAATACCTTTATTCAGCATGCCTACCTGTGCCATTTTTA
GGAAGAATGTATAGAACAGAACTGCATTTTCAGGTTATTAGTTTTAAACGACAACTTCAGGTGGGAAGTCAGCTGTCTGCAGTATTAAAA
TATGTATGATGAAGGGGAAATGTTCTGAAAAAGAAATACACTTAGCATTTCTAAGGATTACTATACTAACATGTATCAACAAAAATATCT
CCTTGGTCTTGATGTAACCAAACTTGATTTTATATCTGCATCCAGAGATGATGCTGATTCAGTAAAGTCAACAAGAATAACTGAAAGTCC
ATATGACACCTGTCCTAAGTTACTACCGTGGGCTATTTCTACTACGGGGCTATTTCACTAAAGCATTTTGAAAATAAAAAGTAAAAGATA
ACATGGTAATTATTACTTTTTATTAATTTAGAGCATTTGAAGTATAAAAATAAAAGGCTTTTGACATACTGTATATACAT

>31152_31152_3_FOXN3-SLC25A21_FOXN3_chr14_89747294_ENST00000261302_SLC25A21_chr14_37344209_ENST00000331299_length(amino acids)=524AA_BP=246
MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDL
DDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERS
QSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQGLVEICLMHPLDVVKTRFQIQR
CATDPNSYKSLVDSFRMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFAIAGLGSGLTEAIVVNPFEVVKV
GLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVIN
IPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQENW

--------------------------------------------------------------
>31152_31152_4_FOXN3-SLC25A21_FOXN3_chr14_89747294_ENST00000261302_SLC25A21_chr14_37344209_ENST00000555449_length(transcript)=1641nt_BP=761nt
AGGAGCCTTCACGTAAATGGGTCCAGTCATGCCTCCCAGTAAGAAGCCAGAAAGCTCAGGAATTAGTGTCTCCAGTGGACTGAGTCAGTG
TTACGGGGGCAGCGGTTTCTCCAAGGCCCTTCAGGAAGACGATGACCTCGACTTTTCTCTGCCTGACATCCGATTAGAAGAGGGGGCCAT
GGAAGATGAAGAGCTGACCAACCTGAACTGGCTGCACGAGAGCAAGAACTTGCTGAAGAGCTTTGGGGAGTCGGTCCTCAGGAGTGTCAG
CCCCGTCCAGGACCTGGACGATGACACCCCCCCATCCCCTGCCCACTCTGACATGCCCTACGATGCCAGGCAGAACCCCAACTGCAAACC
CCCCTACTCCTTCAGCTGCCTCATATTTATGGCCATCGAGGACTCTCCAACCAAGCGCCTGCCAGTGAAGGATATCTACAACTGGATCTT
GGAACATTTTCCGTATTTTGCAAATGCACCTACTGGGTGGAAAAACTCAGTGAGACACAATTTATCATTGAATAAGTGTTTTAAGAAAGT
GGACAAAGAGAGGAGTCAGAGTATTGGGAAAGGGTCGTTGTGGTGCATAGACCCAGAGTATAGACAAAATCTAATTCAGGCTTTGAAAAA
GACACCTTATCACCCACACCCACACGTGTTCAATACACCTCCCACCTGTCCTCAGGCATATCAAAGCACATCAGGTCCACCCATCTGGCC
GGGCAGTACCTTCTTCAAGAGAAATGGAGCCCTTCTCCAAGGTCTTGTAGAAATTTGCCTGATGCACCCCCTAGATGTGGTGAAAACCAG
GTTTCAGATTCAGAGATGTGCAACCGATCCAAACAGTTATAAAAGCTTGGTAGACAGCTTTCGAATGATTTTCCAAATGGAAGGGTTATT
TGGTTTTTACAAGGGAATTCTGCCACCTATCTTGGCTGAAACCCCAAAAAGAGCAGTGAAGTTTTTCACCTTTGAGCAGTACAAGAAATT
GCTGGGATATGTGTCACTGTCACCAGCATTGACATTCGCCATTGCTGGATTGGGATCTGGACTAACAGAAGCCATTGTAGTTAACCCTTT
TGAGGTAGTAAAAGTTGGCTTGCAAGCAAATCGGAACACATTTGCAGAGCAACCATCCACTGTGGGTTATGCAAGACAAATCATTAAGAA
GGAAGGCTGGGGACTCCAGGGCCTCAACAAAGGATTAACTGCAACTTTGGGACGACATGGAGTTTTCAACATGGTTTATTTTGGCTTCTA
CTACAATGTCAAAAACATGATTCCTGTCAATAAGGATCCAATCTTGGAGTTTTGGAGAAAATTTGGGATTGGTCTTCTCTCGGGGACAAT
AGCCTCAGTCATTAACATCCCTTTTGATGTTGCCAAAAGTAGGATTCAAGGGCCTCAACCAGTTCCTGGAGAGATCAAGTACAGAACCTG
TTTTAAAACAATGGCAACAGTCTATCAGGAAGAAGGGATTTTAGCTTTGTACAAAGGCCTGCTTCCCAAGATTATGAGACTTGGACCAGG
TGGTGCAGTGATGCTGCTGGTTTATGAATACACCTATTCATGGCTTCAAGAGAACTGACTGGGAACTCCAGATGTCAATGGAAGTTTTAC
AAGATCAAAGGAAGACTATGG

>31152_31152_4_FOXN3-SLC25A21_FOXN3_chr14_89747294_ENST00000261302_SLC25A21_chr14_37344209_ENST00000555449_length(amino acids)=523AA_BP=246
MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDL
DDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERS
QSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQGLVEICLMHPLDVVKTRFQIQR
CATDPNSYKSLVDSFRMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFAIAGLGSGLTEAIVVNPFEVVKV
GLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVIN
IPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQEN

--------------------------------------------------------------
>31152_31152_5_FOXN3-SLC25A21_FOXN3_chr14_89747294_ENST00000557258_SLC25A21_chr14_37344209_ENST00000331299_length(transcript)=3200nt_BP=1001nt
GCGGGAGGACGCGCGGCGCGCCCGGCGGACGCCGCAGGTCCCATGCCGCGCCGCGACCCCCGCGCCCCTGCCGCCCGCGCCCGCGGCCGC
CCCCCGCCGCCCGCCGCCCCGGGCTCGCCGCGCCGCGCCCGCGCGTCCTTAGCGGGGCCACCGAGCGATGCCCGCCGGGCGCCCGCGAAA
GTTTGTCGGCTCCTGCTGAAGGGCAGCGGCGCCCCCGCACCCCCGTGCCCCGCTCCGGCCAGGAGCCTTCACGTAAATGGGTCCAGTCAT
GCCTCCCAGTAAGAAGCCAGAAAGCTCAGGAATTAGTGTCTCCAGTGGACTGAGTCAGTGTTACGGGGGCAGCGGTTTCTCCAAGGCCCT
TCAGGAAGACGATGACCTCGACTTTTCTCTGCCTGACATCCGATTAGAAGAGGGGGCCATGGAAGATGAAGAGCTGACCAACCTGAACTG
GCTGCACGAGAGCAAGAACTTGCTGAAGAGCTTTGGGGAGTCGGTCCTCAGGAGTGTCAGCCCCGTCCAGGACCTGGACGATGACACCCC
CCCATCCCCTGCCCACTCTGACATGCCCTACGATGCCAGGCAGAACCCCAACTGCAAACCCCCCTACTCCTTCAGCTGCCTCATATTTAT
GGCCATCGAGGACTCTCCAACCAAGCGCCTGCCAGTGAAGGATATCTACAACTGGATCTTGGAACATTTTCCGTATTTTGCAAATGCACC
TACTGGGTGGAAAAACTCAGTGAGACACAATTTATCATTGAATAAGTGTTTTAAGAAAGTGGACAAAGAGAGGAGTCAGAGTATTGGGAA
AGGGTCGTTGTGGTGCATAGACCCAGAGTATAGACAAAATCTAATTCAGGCTTTGAAAAAGACACCTTATCACCCACACCCACACGTGTT
CAATACACCTCCCACCTGTCCTCAGGCATATCAAAGCACATCAGGTCCACCCATCTGGCCGGGCAGTACCTTCTTCAAGAGAAATGGAGC
CCTTCTCCAAGGTCTTGTAGAAATTTGCCTGATGCACCCCCTAGATGTGGTGAAAACCAGGTTTCAGATTCAGAGATGTGCAACCGATCC
AAACAGTTATAAAAGCTTGGTAGACAGCTTTCGAATGATTTTCCAAATGGAAGGGTTATTTGGTTTTTACAAGGGAATTCTGCCACCTAT
CTTGGCTGAAACCCCAAAAAGAGCAGTGAAGTTTTTCACCTTTGAGCAGTACAAGAAATTGCTGGGATATGTGTCACTGTCACCAGCATT
GACATTCGCCATTGCTGGATTGGGATCTGGACTAACAGAAGCCATTGTAGTTAACCCTTTTGAGGTAGTAAAAGTTGGCTTGCAAGCAAA
TCGGAACACATTTGCAGAGCAACCATCCACTGTGGGTTATGCAAGACAAATCATTAAGAAGGAAGGCTGGGGACTCCAGGGCCTCAACAA
AGGATTAACTGCAACTTTGGGACGACATGGAGTTTTCAACATGGTTTATTTTGGCTTCTACTACAATGTCAAAAACATGATTCCTGTCAA
TAAGGATCCAATCTTGGAGTTTTGGAGAAAATTTGGGATTGGTCTTCTCTCGGGGACAATAGCCTCAGTCATTAACATCCCTTTTGATGT
TGCCAAAAGTAGGATTCAAGGGCCTCAACCAGTTCCTGGAGAGATCAAGTACAGAACCTGTTTTAAAACAATGGCAACAGTCTATCAGGA
AGAAGGGATTTTAGCTTTGTACAAAGGCCTGCTTCCCAAGATTATGAGACTTGGACCAGGTGGTGCAGTGATGCTGCTGGTTTATGAATA
CACCTATTCATGGCTTCAAGAGAACTGGTGATTGCCTATGAAGTGTTTTTCCCCCTTGAGATAATGGATATTTGCTATGCAGCACCATGA
AGAAGAGAGACTATCGATCGGCCAGGTGTATAATTATGAAGGAGAAAACTGTTCAAGAACAAAATCTATTTTAATACTTTAAAAAATGTC
TATAGGCAACTTGAGATTATAGTTTTGGCTGTATAAATAAAACTGTGAGAAGAAAAAAATAATATGAAACAATGAGGTATTTAAAGTGAA
TATAGAAAAATAGCATAGAAATCATATATTTATTTCATAAAATAAATAGAAACTTTGTCTCCTGTGTTCCTCTTCAATGCTTCACAATGA
AAATTCATTGTATTGATCAGCATTTTTCCTAAGAGGTCTAGAAATGCTTAAACTATTGAAAATAAATCAAATTATTCAAAGACTGGATTA
AAAAAAAGTTAAGCCAAAATTTAAGCAGTTTTTATAATGAATTAAATTATTCCATAAATAATATTTAAAGAGCACAAGAAAAATTTTTTA
AAGTGCACTAAAATGACCTTTTAAGAATGTTTAATTTTATGAATACTATGTTAAAATGTAAATCTGTTGGTTTTTTTTAGTAACTATGCA
CATATCAGCTCTATTTTCCTACATCTACTTTATATCTCATATTGCTGTAAGATAATAAATAGGTATTTTAAAACATTGTTTAAAACAGAA
TGTTAAAACACTGTTGTTTAAGCATGTTTAAATCAAGGTATTCCAAATCTCTTCTAACACAAGTAGGAAACATGAAATAAAATTTACTTT
CCTCCACATAGTTCTCTTTGAAGATAAGTTTTGTTGATGAGATATTGTCATGTTAAATCACAAATTGGAAACACCTTTGGACCCATTTGT
CAGCCATCAGTATTTGCATCCAAATACCTTTATTCAGCATGCCTACCTGTGCCATTTTTAGGAAGAATGTATAGAACAGAACTGCATTTT
CAGGTTATTAGTTTTAAACGACAACTTCAGGTGGGAAGTCAGCTGTCTGCAGTATTAAAATATGTATGATGAAGGGGAAATGTTCTGAAA
AAGAAATACACTTAGCATTTCTAAGGATTACTATACTAACATGTATCAACAAAAATATCTCCTTGGTCTTGATGTAACCAAACTTGATTT
TATATCTGCATCCAGAGATGATGCTGATTCAGTAAAGTCAACAAGAATAACTGAAAGTCCATATGACACCTGTCCTAAGTTACTACCGTG
GGCTATTTCTACTACGGGGCTATTTCACTAAAGCATTTTGAAAATAAAAAGTAAAAGATAACATGGTAATTATTACTTTTTATTAATTTA
GAGCATTTGAAGTATAAAAATAAAAGGCTTTTGACATACTGTATATACAT

>31152_31152_5_FOXN3-SLC25A21_FOXN3_chr14_89747294_ENST00000557258_SLC25A21_chr14_37344209_ENST00000331299_length(amino acids)=524AA_BP=246
MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDL
DDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERS
QSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQGLVEICLMHPLDVVKTRFQIQR
CATDPNSYKSLVDSFRMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFAIAGLGSGLTEAIVVNPFEVVKV
GLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVIN
IPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQENW

--------------------------------------------------------------
>31152_31152_6_FOXN3-SLC25A21_FOXN3_chr14_89747294_ENST00000557258_SLC25A21_chr14_37344209_ENST00000555449_length(transcript)=1881nt_BP=1001nt
GCGGGAGGACGCGCGGCGCGCCCGGCGGACGCCGCAGGTCCCATGCCGCGCCGCGACCCCCGCGCCCCTGCCGCCCGCGCCCGCGGCCGC
CCCCCGCCGCCCGCCGCCCCGGGCTCGCCGCGCCGCGCCCGCGCGTCCTTAGCGGGGCCACCGAGCGATGCCCGCCGGGCGCCCGCGAAA
GTTTGTCGGCTCCTGCTGAAGGGCAGCGGCGCCCCCGCACCCCCGTGCCCCGCTCCGGCCAGGAGCCTTCACGTAAATGGGTCCAGTCAT
GCCTCCCAGTAAGAAGCCAGAAAGCTCAGGAATTAGTGTCTCCAGTGGACTGAGTCAGTGTTACGGGGGCAGCGGTTTCTCCAAGGCCCT
TCAGGAAGACGATGACCTCGACTTTTCTCTGCCTGACATCCGATTAGAAGAGGGGGCCATGGAAGATGAAGAGCTGACCAACCTGAACTG
GCTGCACGAGAGCAAGAACTTGCTGAAGAGCTTTGGGGAGTCGGTCCTCAGGAGTGTCAGCCCCGTCCAGGACCTGGACGATGACACCCC
CCCATCCCCTGCCCACTCTGACATGCCCTACGATGCCAGGCAGAACCCCAACTGCAAACCCCCCTACTCCTTCAGCTGCCTCATATTTAT
GGCCATCGAGGACTCTCCAACCAAGCGCCTGCCAGTGAAGGATATCTACAACTGGATCTTGGAACATTTTCCGTATTTTGCAAATGCACC
TACTGGGTGGAAAAACTCAGTGAGACACAATTTATCATTGAATAAGTGTTTTAAGAAAGTGGACAAAGAGAGGAGTCAGAGTATTGGGAA
AGGGTCGTTGTGGTGCATAGACCCAGAGTATAGACAAAATCTAATTCAGGCTTTGAAAAAGACACCTTATCACCCACACCCACACGTGTT
CAATACACCTCCCACCTGTCCTCAGGCATATCAAAGCACATCAGGTCCACCCATCTGGCCGGGCAGTACCTTCTTCAAGAGAAATGGAGC
CCTTCTCCAAGGTCTTGTAGAAATTTGCCTGATGCACCCCCTAGATGTGGTGAAAACCAGGTTTCAGATTCAGAGATGTGCAACCGATCC
AAACAGTTATAAAAGCTTGGTAGACAGCTTTCGAATGATTTTCCAAATGGAAGGGTTATTTGGTTTTTACAAGGGAATTCTGCCACCTAT
CTTGGCTGAAACCCCAAAAAGAGCAGTGAAGTTTTTCACCTTTGAGCAGTACAAGAAATTGCTGGGATATGTGTCACTGTCACCAGCATT
GACATTCGCCATTGCTGGATTGGGATCTGGACTAACAGAAGCCATTGTAGTTAACCCTTTTGAGGTAGTAAAAGTTGGCTTGCAAGCAAA
TCGGAACACATTTGCAGAGCAACCATCCACTGTGGGTTATGCAAGACAAATCATTAAGAAGGAAGGCTGGGGACTCCAGGGCCTCAACAA
AGGATTAACTGCAACTTTGGGACGACATGGAGTTTTCAACATGGTTTATTTTGGCTTCTACTACAATGTCAAAAACATGATTCCTGTCAA
TAAGGATCCAATCTTGGAGTTTTGGAGAAAATTTGGGATTGGTCTTCTCTCGGGGACAATAGCCTCAGTCATTAACATCCCTTTTGATGT
TGCCAAAAGTAGGATTCAAGGGCCTCAACCAGTTCCTGGAGAGATCAAGTACAGAACCTGTTTTAAAACAATGGCAACAGTCTATCAGGA
AGAAGGGATTTTAGCTTTGTACAAAGGCCTGCTTCCCAAGATTATGAGACTTGGACCAGGTGGTGCAGTGATGCTGCTGGTTTATGAATA
CACCTATTCATGGCTTCAAGAGAACTGACTGGGAACTCCAGATGTCAATGGAAGTTTTACAAGATCAAAGGAAGACTATGG

>31152_31152_6_FOXN3-SLC25A21_FOXN3_chr14_89747294_ENST00000557258_SLC25A21_chr14_37344209_ENST00000555449_length(amino acids)=523AA_BP=246
MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDL
DDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERS
QSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQGLVEICLMHPLDVVKTRFQIQR
CATDPNSYKSLVDSFRMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFAIAGLGSGLTEAIVVNPFEVVKV
GLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVIN
IPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQEN

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Fusion Gene PPI Analysis for FOXN3-SLC25A21


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FOXN3-SLC25A21


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FOXN3-SLC25A21


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource