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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CHGA-DLK1 (FusionGDB2 ID:HG1113TG8788)

Fusion Gene Summary for CHGA-DLK1

Fusion gene summary

Fusion gene information	Fusion gene name: CHGA-DLK1
	Fusion gene ID: hg1113tg8788
		Hgene	Tgene
	Gene symbol	CHGA	DLK1
	Gene ID	1113	8788
	Gene name	chromogranin A	delta like non-canonical Notch ligand 1
	Synonyms	CGA	DLK\|DLK-1\|Delta1\|FA1\|PREF1\|Pref-1\|ZOG\|pG2
	Cytomap	('CHGA')('DLK1') 14q32.12	14q32.2
	Type of gene	protein-coding	protein-coding
	Description	chromogranin-ASP-Ibetagranin (N-terminal fragment of chromogranin A)catestatinchromofunginparathyroid secretory protein 1pituitary secretory protein I	protein delta homolog 1delta-like 1 homologfetal antigen 1preadipocyte factor 1secredeltin
	Modification date	20200315	20200329
	UniProtAcc	P10645	.
	Ensembl transtripts involved in fusion gene	ENST00000216492, ENST00000334654, ENST00000553866,
Fusion gene scores	* DoF score	11 X 15 X 3=495	11 X 12 X 3=396
	# samples	15	10
	** MAII score	log2(15/495*10)=-1.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/396*10)=-1.98550043030488 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CHGA [Title/Abstract] AND DLK1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CHGA(93401530)-DLK1(101201380), # samples:1 CHGA(93399075)-DLK1(101201217), # samples:1
Anticipated loss of major functional domain due to fusion event.	CHGA-DLK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CHGA-DLK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CHGA-DLK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CHGA-DLK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CHGA	GO:0002551	mast cell chemotaxis	21214543
Hgene	CHGA	GO:0032762	mast cell cytokine production	21214543
Hgene	CHGA	GO:0033604	negative regulation of catecholamine secretion	15326220
Hgene	CHGA	GO:0043303	mast cell degranulation	21214543
Hgene	CHGA	GO:0045576	mast cell activation	21214543
Hgene	CHGA	GO:0050829	defense response to Gram-negative bacterium	15723172
Hgene	CHGA	GO:0050830	defense response to Gram-positive bacterium	15723172
Tgene	DLK1	GO:0045746	negative regulation of Notch signaling pathway	25093684

Fusion gene breakpoints across CHGA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DLK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PCPG	TCGA-RT-A6YA-01A	CHGA	chr14	93401530	+	DLK1	chr14	101201380	+
ChimerDB4	PCPG	TCGA-WB-A81M-01A	CHGA	chr14	93399075	+	DLK1	chr14	101201217	+

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Fusion Gene ORF analysis for CHGA-DLK1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3UTR	ENST00000216492	ENST00000331224	CHGA	chr14	93401530	+	DLK1	chr14	101201380	+
3UTR-3UTR	ENST00000216492	ENST00000341267	CHGA	chr14	93401530	+	DLK1	chr14	101201380	+
3UTR-3UTR	ENST00000334654	ENST00000331224	CHGA	chr14	93401530	+	DLK1	chr14	101201380	+
3UTR-3UTR	ENST00000334654	ENST00000341267	CHGA	chr14	93401530	+	DLK1	chr14	101201380	+
3UTR-intron	ENST00000216492	ENST00000556051	CHGA	chr14	93401530	+	DLK1	chr14	101201380	+
3UTR-intron	ENST00000334654	ENST00000556051	CHGA	chr14	93401530	+	DLK1	chr14	101201380	+
5CDS-intron	ENST00000216492	ENST00000556051	CHGA	chr14	93399075	+	DLK1	chr14	101201217	+
5CDS-intron	ENST00000334654	ENST00000556051	CHGA	chr14	93399075	+	DLK1	chr14	101201217	+
In-frame	ENST00000216492	ENST00000331224	CHGA	chr14	93399075	+	DLK1	chr14	101201217	+
In-frame	ENST00000216492	ENST00000341267	CHGA	chr14	93399075	+	DLK1	chr14	101201217	+
In-frame	ENST00000334654	ENST00000331224	CHGA	chr14	93399075	+	DLK1	chr14	101201217	+
In-frame	ENST00000334654	ENST00000341267	CHGA	chr14	93399075	+	DLK1	chr14	101201217	+
intron-3CDS	ENST00000553866	ENST00000331224	CHGA	chr14	93399075	+	DLK1	chr14	101201217	+
intron-3CDS	ENST00000553866	ENST00000341267	CHGA	chr14	93399075	+	DLK1	chr14	101201217	+
intron-3UTR	ENST00000553866	ENST00000331224	CHGA	chr14	93401530	+	DLK1	chr14	101201380	+
intron-3UTR	ENST00000553866	ENST00000341267	CHGA	chr14	93401530	+	DLK1	chr14	101201380	+
intron-intron	ENST00000553866	ENST00000556051	CHGA	chr14	93401530	+	DLK1	chr14	101201380	+
intron-intron	ENST00000553866	ENST00000556051	CHGA	chr14	93399075	+	DLK1	chr14	101201217	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000216492

CHGA

chr14

93399075

ENST00000341267

DLK1

chr14

101201217

1531

1209

157

1224

355

ENST00000216492

CHGA

chr14

93399075

ENST00000331224

DLK1

chr14

101201217

1456

1209

157

1224

355

ENST00000334654

CHGA

chr14

93399075

ENST00000341267

DLK1

chr14

101201217

982

660

675

204

ENST00000334654

CHGA

chr14

93399075

ENST00000331224

DLK1

chr14

101201217

907

660

675

204

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000216492	ENST00000341267	CHGA	chr14	93399075	+	DLK1	chr14	101201217	+	0.007313544	0.9926865
ENST00000216492	ENST00000331224	CHGA	chr14	93399075	+	DLK1	chr14	101201217	+	0.007244905	0.9927551
ENST00000334654	ENST00000341267	CHGA	chr14	93399075	+	DLK1	chr14	101201217	+	0.02174618	0.97825384
ENST00000334654	ENST00000331224	CHGA	chr14	93399075	+	DLK1	chr14	101201217	+	0.016084528	0.9839155

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Fusion Genomic Features for CHGA-DLK1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for CHGA-DLK1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:93401530/chr14:101201380)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CHGA P10645	.
FUNCTION: [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172 and PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269\|PubMed:15326220, ECO:0000269\|PubMed:15723172, ECO:0000269\|PubMed:21214543, ECO:0000269\|PubMed:24723458, ECO:0000303\|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250\|UniProtKB:P26339}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DLK1

chr14:93399075

chr14:101201217

ENST00000331224

127_168

311.0

Domain

EGF-like 4

Tgene

DLK1

chr14:93399075

chr14:101201217

ENST00000331224

170_206

311.0

Domain

EGF-like 5

Tgene

DLK1

chr14:93399075

chr14:101201217

ENST00000331224

208_245

311.0

Domain

EGF-like 6

Tgene

DLK1

chr14:93399075

chr14:101201217

ENST00000331224

24_55

311.0

Domain

EGF-like 1

Tgene

DLK1

chr14:93399075

chr14:101201217

ENST00000331224

53_86

311.0

Domain

EGF-like 2

Tgene

DLK1

chr14:93399075

chr14:101201217

ENST00000331224

88_125

311.0

Domain

EGF-like 3

Tgene

DLK1

chr14:93399075

chr14:101201217

ENST00000341267

127_168

384.0

Domain

EGF-like 4

Tgene

DLK1

chr14:93399075

chr14:101201217

ENST00000341267

170_206

384.0

Domain

EGF-like 5

Tgene

DLK1

chr14:93399075

chr14:101201217

ENST00000341267

208_245

384.0

Domain

EGF-like 6

Tgene

DLK1

chr14:93399075

chr14:101201217

ENST00000341267

24_55

384.0

Domain

EGF-like 1

Tgene

DLK1

chr14:93399075

chr14:101201217

ENST00000341267

53_86

384.0

Domain

EGF-like 2

Tgene

DLK1

chr14:93399075

chr14:101201217

ENST00000341267

88_125

384.0

Domain

EGF-like 3

Tgene

DLK1

chr14:93399075

chr14:101201217

ENST00000331224

24_303

311.0

Topological domain

Extracellular

Tgene

DLK1

chr14:93399075

chr14:101201217

ENST00000331224

328_383

311.0

Topological domain

Cytoplasmic

Tgene

DLK1

chr14:93399075

chr14:101201217

ENST00000341267

24_303

384.0

Topological domain

Extracellular

Tgene

DLK1

chr14:93399075

chr14:101201217

ENST00000341267

328_383

384.0

Topological domain

Cytoplasmic

Tgene

DLK1

chr14:93399075

chr14:101201217

ENST00000331224

304_327

311.0

Transmembrane

Helical

Tgene

DLK1

chr14:93399075

chr14:101201217

ENST00000341267

304_327

384.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CHGA

chr14:93399075

chr14:101201217

ENST00000216492

181_191

458.0

Region

Note=O-glycosylated at one site only in cerebrospinal fluid

Hgene

CHGA

chr14:93399075

chr14:101201217

ENST00000216492

41_59

458.0

Region

Note=O-glycosylated at one site only in cerebrospinal fluid

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Fusion Gene Sequence for CHGA-DLK1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>16437_16437_1_CHGA-DLK1_CHGA_chr14_93399075_ENST00000216492_DLK1_chr14_101201217_ENST00000331224_length(transcript)=1456nt_BP=1209nt
AAGGGGGCGGCACCGCTGACGTCATTTCCGGGGTCGGGGTATATAAGCGGGGCGCGAGGGCGCTGCTGCTGCCACCGCTCCTGCCACTGC
AGTGCTCGAGCCCCGTGCAGGGGAGCTTGCGGGAGGATCGACCGACAGACGGACGCACGCCGAGGCACTGCGCCCCCAGCCCCGCGCCGG
TGCCACCGCAGCCCGACCCCGGCCGCCAGTCCAGCCGCCCCTCGCCCGGTGCCTAGGTGCCCGGCCCCACACCGCCAGCTGCTCGGCGCC
CGGGTCCGCCATGCGCTCCGCCGCTGTCCTGGCTCTTCTGCTCTGCGCCGGGCAAGTCACTGCGCTCCCTGTGAACAGCCCTATGAATAA
AGGGGATACCGAGGTGATGAAATGCATCGTTGAGGTCATCTCCGACACACTTTCCAAGCCCAGCCCCATGCCTGTCAGCCAGGAATGTTT
TGAGACACTCCGAGGAGATGAACGGATCCTTTCCATTCTGAGACATCAGAATTTACTGAAGGAGCTCCAAGACCTCGCTCTCCAAGGCGC
CAAGGAGAGGGCACATCAGCAGAAGAAACACAGCGGTTTTGAAGATGAACTCTCAGAGGTTCTTGAGAACCAGAGCAGCCAGGCCGAGCT
GAAAGAGGCGGTGGAAGAGCCATCATCCAAGGATGTTATGGAGAAAAGAGAGGATTCCAAGGAGGCAGAGAAAAGTGGTGAAGCCACAGA
CGGAGCCAGGCCCCAGGCCCTCCCGGAGCCCATGCAGGAGTCCAAGGCTGAGGGGAACAATCAGGCCCCTGGGGAGGAAGAGGAGGAGGA
GGAGGAGGCCACCAACACCCACCCTCCAGCCAGCCTCCCCAGCCAGAAATACCCAGGCCCACAGGCCGAGGGGGACAGTGAGGGCCTCTC
TCAGGGTCTGGTGGACAGAGAGAAGGGCCTGAGTGCAGAGCCAGGGTGGCAGGCAAAGAGAGAAGAGGAGGAGGAGGAGGAGGAGGAGGC
TGAGGCTGGAGAGGAGGCTGTCCCCGAGGAAGAAGGCCCCACTGTAGTGCTGAACCCCCACCCGAGCCTTGGCTACAAGGAGATCCGGAA
AGGCGAGAGCGACGAGGCTGGAGGCCATCCTCCCGGGAGGACAGCCTTGAGGCGGGCCTGCCCCTCCAGGTCCGAGGCTACCCCGAGGAG
AAGAAAGAGGAGGAGGGCAGCGCAAACCGCAGACCAGAGCGACGAGGAGATCTAAGCAGCGTTCCCACAGCCCCCTCTAGATTCTTGGAG
TTCCGCAGAGCTTACTATACGCGGTCTGTCCTAATCTTTGTGGTGTTCGCTATCTCTTGTGTCAAATCTGGTGAACGCTACGCTTACATA
TATTGTCTTTGTGCTGCTGTGTGACAAACGCAATGCAAAAACAATCCTCTTTCTCTCTCTTAATGCATGATACAGAATAATAATAAGAAT

>16437_16437_1_CHGA-DLK1_CHGA_chr14_93399075_ENST00000216492_DLK1_chr14_101201217_ENST00000331224_length(amino acids)=355AA_BP=
MRPQPRAGATAARPRPPVQPPLARCLGARPHTASCSAPGSAMRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSP
MPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEA
EKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREE

--------------------------------------------------------------
>16437_16437_2_CHGA-DLK1_CHGA_chr14_93399075_ENST00000216492_DLK1_chr14_101201217_ENST00000341267_length(transcript)=1531nt_BP=1209nt
AAGGGGGCGGCACCGCTGACGTCATTTCCGGGGTCGGGGTATATAAGCGGGGCGCGAGGGCGCTGCTGCTGCCACCGCTCCTGCCACTGC
AGTGCTCGAGCCCCGTGCAGGGGAGCTTGCGGGAGGATCGACCGACAGACGGACGCACGCCGAGGCACTGCGCCCCCAGCCCCGCGCCGG
TGCCACCGCAGCCCGACCCCGGCCGCCAGTCCAGCCGCCCCTCGCCCGGTGCCTAGGTGCCCGGCCCCACACCGCCAGCTGCTCGGCGCC
CGGGTCCGCCATGCGCTCCGCCGCTGTCCTGGCTCTTCTGCTCTGCGCCGGGCAAGTCACTGCGCTCCCTGTGAACAGCCCTATGAATAA
AGGGGATACCGAGGTGATGAAATGCATCGTTGAGGTCATCTCCGACACACTTTCCAAGCCCAGCCCCATGCCTGTCAGCCAGGAATGTTT
TGAGACACTCCGAGGAGATGAACGGATCCTTTCCATTCTGAGACATCAGAATTTACTGAAGGAGCTCCAAGACCTCGCTCTCCAAGGCGC
CAAGGAGAGGGCACATCAGCAGAAGAAACACAGCGGTTTTGAAGATGAACTCTCAGAGGTTCTTGAGAACCAGAGCAGCCAGGCCGAGCT
GAAAGAGGCGGTGGAAGAGCCATCATCCAAGGATGTTATGGAGAAAAGAGAGGATTCCAAGGAGGCAGAGAAAAGTGGTGAAGCCACAGA
CGGAGCCAGGCCCCAGGCCCTCCCGGAGCCCATGCAGGAGTCCAAGGCTGAGGGGAACAATCAGGCCCCTGGGGAGGAAGAGGAGGAGGA
GGAGGAGGCCACCAACACCCACCCTCCAGCCAGCCTCCCCAGCCAGAAATACCCAGGCCCACAGGCCGAGGGGGACAGTGAGGGCCTCTC
TCAGGGTCTGGTGGACAGAGAGAAGGGCCTGAGTGCAGAGCCAGGGTGGCAGGCAAAGAGAGAAGAGGAGGAGGAGGAGGAGGAGGAGGC
TGAGGCTGGAGAGGAGGCTGTCCCCGAGGAAGAAGGCCCCACTGTAGTGCTGAACCCCCACCCGAGCCTTGGCTACAAGGAGATCCGGAA
AGGCGAGAGCGACGAGGCTGGAGGCCATCCTCCCGGGAGGACAGCCTTGAGGCGGGCCTGCCCCTCCAGGTCCGAGGCTACCCCGAGGAG
AAGAAAGAGGAGGAGGGCAGCGCAAACCGCAGACCAGAGCGACGAGGAGATCTAAGCAGCGTTCCCACAGCCCCCTCTAGATTCTTGGAG
TTCCGCAGAGCTTACTATACGCGGTCTGTCCTAATCTTTGTGGTGTTCGCTATCTCTTGTGTCAAATCTGGTGAACGCTACGCTTACATA
TATTGTCTTTGTGCTGCTGTGTGACAAACGCAATGCAAAAACAATCCTCTTTCTCTCTCTTAATGCATGATACAGAATAATAATAAGAAT
TTCATCTTTAAATGAGTAAGAGAAATAAGTATGTTATTCTAAAATCTAAACTCAAATGAAATTTCAAAAAAGACCAAAAAAAAACAAGGC

>16437_16437_2_CHGA-DLK1_CHGA_chr14_93399075_ENST00000216492_DLK1_chr14_101201217_ENST00000341267_length(amino acids)=355AA_BP=
MRPQPRAGATAARPRPPVQPPLARCLGARPHTASCSAPGSAMRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSP
MPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEA
EKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREE

--------------------------------------------------------------
>16437_16437_3_CHGA-DLK1_CHGA_chr14_93399075_ENST00000334654_DLK1_chr14_101201217_ENST00000331224_length(transcript)=907nt_BP=660nt
CGAGCCCCGTGCAGGGGAGCTTGCGGGAGGATCGACCGACAGACGGACGCACGCCGAGGCACTGCGCCCCCAGCCCCGCGCCGGTGCCAC
CGCAGCCCGACCCCGGCCGCCAGTCCAGCCGCCCCTCGCCCGGTGCCTAGGTGCCCGGCCCCACACCGCCAGCTGCTCGGCGCCCGGGTC
CGCCATGCGCTCCGCCGCTGTCCTGGCTCTTCTGCTCTGCGCCGGGCAAGTCACTGCGCTCCCTGTGAACAGCCCTATGAATAAAGGGGA
TACCGAGGTGATGAAATGCATCGTTGAGGTCATCTCCGACACACTTTCCAAGCCCAGCCCCATGCCTGTCAGCCAGGAATGTTTTGAGAC
ACTCCGAGGAGATGAACGGATCCTTTCCATTCTGAGACATCAGAATTTACTGAAGGAGCTCCAAGACCTCGCTCTCCAAGGCGCCAAGGA
GAGGGCACATCAGCAGAAGAAACACAGCGGTTTTGAAGATGAACTCTCAGAGGTTCTTGAGAACCAGAGCAGCCAGGCCGAGCTGAAAGG
CGACGAGGCTGGAGGCCATCCTCCCGGGAGGACAGCCTTGAGGCGGGCCTGCCCCTCCAGGTCCGAGGCTACCCCGAGGAGAAGAAAGAG
GAGGAGGGCAGCGCAAACCGCAGACCAGAGCGACGAGGAGATCTAAGCAGCGTTCCCACAGCCCCCTCTAGATTCTTGGAGTTCCGCAGA
GCTTACTATACGCGGTCTGTCCTAATCTTTGTGGTGTTCGCTATCTCTTGTGTCAAATCTGGTGAACGCTACGCTTACATATATTGTCTT
TGTGCTGCTGTGTGACAAACGCAATGCAAAAACAATCCTCTTTCTCTCTCTTAATGCATGATACAGAATAATAATAAGAATTTCATCTTT

>16437_16437_3_CHGA-DLK1_CHGA_chr14_93399075_ENST00000334654_DLK1_chr14_101201217_ENST00000331224_length(amino acids)=204AA_BP=
MRPQPRAGATAARPRPPVQPPLARCLGARPHTASCSAPGSAMRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSP
MPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKGDEAGGHPPGRTALRRACPSR

--------------------------------------------------------------
>16437_16437_4_CHGA-DLK1_CHGA_chr14_93399075_ENST00000334654_DLK1_chr14_101201217_ENST00000341267_length(transcript)=982nt_BP=660nt
CGAGCCCCGTGCAGGGGAGCTTGCGGGAGGATCGACCGACAGACGGACGCACGCCGAGGCACTGCGCCCCCAGCCCCGCGCCGGTGCCAC
CGCAGCCCGACCCCGGCCGCCAGTCCAGCCGCCCCTCGCCCGGTGCCTAGGTGCCCGGCCCCACACCGCCAGCTGCTCGGCGCCCGGGTC
CGCCATGCGCTCCGCCGCTGTCCTGGCTCTTCTGCTCTGCGCCGGGCAAGTCACTGCGCTCCCTGTGAACAGCCCTATGAATAAAGGGGA
TACCGAGGTGATGAAATGCATCGTTGAGGTCATCTCCGACACACTTTCCAAGCCCAGCCCCATGCCTGTCAGCCAGGAATGTTTTGAGAC
ACTCCGAGGAGATGAACGGATCCTTTCCATTCTGAGACATCAGAATTTACTGAAGGAGCTCCAAGACCTCGCTCTCCAAGGCGCCAAGGA
GAGGGCACATCAGCAGAAGAAACACAGCGGTTTTGAAGATGAACTCTCAGAGGTTCTTGAGAACCAGAGCAGCCAGGCCGAGCTGAAAGG
CGACGAGGCTGGAGGCCATCCTCCCGGGAGGACAGCCTTGAGGCGGGCCTGCCCCTCCAGGTCCGAGGCTACCCCGAGGAGAAGAAAGAG
GAGGAGGGCAGCGCAAACCGCAGACCAGAGCGACGAGGAGATCTAAGCAGCGTTCCCACAGCCCCCTCTAGATTCTTGGAGTTCCGCAGA
GCTTACTATACGCGGTCTGTCCTAATCTTTGTGGTGTTCGCTATCTCTTGTGTCAAATCTGGTGAACGCTACGCTTACATATATTGTCTT
TGTGCTGCTGTGTGACAAACGCAATGCAAAAACAATCCTCTTTCTCTCTCTTAATGCATGATACAGAATAATAATAAGAATTTCATCTTT

>16437_16437_4_CHGA-DLK1_CHGA_chr14_93399075_ENST00000334654_DLK1_chr14_101201217_ENST00000341267_length(amino acids)=204AA_BP=
MRPQPRAGATAARPRPPVQPPLARCLGARPHTASCSAPGSAMRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSP
MPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKGDEAGGHPPGRTALRRACPSR

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Fusion Gene PPI Analysis for CHGA-DLK1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CHGA-DLK1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CHGA-DLK1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CHGA	C0007131	Non-Small Cell Lung Carcinoma	1	CTD_human
Hgene	CHGA	C0031511	Pheochromocytoma	1	CTD_human
Hgene	CHGA	C0036341	Schizophrenia	1	PSYGENET
Hgene	CHGA	C1257877	Pheochromocytoma, Extra-Adrenal	1	CTD_human
Tgene		C0015934	Fetal Growth Retardation	1	CTD_human
Tgene		C0342544	Idiopathic central precocious puberty	1	ORPHANET
Tgene		C1842466	Uniparental disomy, paternal, chromosome 14	1	ORPHANET
Tgene		C2713368	Hematopoetic Myelodysplasia	1	CTD_human
Tgene		C3463824	MYELODYSPLASTIC SYNDROME	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:CHGA-DLK1 (FusionGDB2 ID:HG1113TG8788)

Fusion Gene Summary for CHGA-DLK1

Fusion Gene ORF analysis for CHGA-DLK1

Fusion Genomic Features for CHGA-DLK1

Fusion Protein Features for CHGA-DLK1

Fusion Gene Sequence for CHGA-DLK1

Fusion Gene PPI Analysis for CHGA-DLK1

Related Drugs for CHGA-DLK1

Related Diseases for CHGA-DLK1

Fusion Gene Studies
in Kim Lab