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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CHI3L1-GMDS (FusionGDB2 ID:HG1116TG2762) |
Fusion Gene Summary for CHI3L1-GMDS |
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Fusion gene information | Fusion gene name: CHI3L1-GMDS | Fusion gene ID: hg1116tg2762 | Hgene | Tgene | Gene symbol | CHI3L1 | GMDS | Gene ID | 1116 | 2762 |
Gene name | chitinase 3 like 1 | GDP-mannose 4,6-dehydratase | |
Synonyms | ASRT7|CGP-39|GP-39|GP39|HC-gp39|HCGP-3P|YK-40|YKL-40|YKL40|YYL-40|hCGP-39 | GMD|SDR3E1 | |
Cytomap | ('CHI3L1')('GMDS') 1q32.1 | 6p25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | chitinase-3-like protein 139 kDa synovial proteincartilage glycoprotein 39chitinase 3-like 1 (cartilage glycoprotein-39) | GDP-mannose 4,6 dehydrataseGDP-D-mannose dehydrataseshort chain dehydrogenase/reductase family 3E, member 1 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P36222 | O60547 | |
Ensembl transtripts involved in fusion gene | ENST00000255409, | ||
Fusion gene scores | * DoF score | 13 X 8 X 7=728 | 14 X 10 X 8=1120 |
# samples | 13 | 15 | |
** MAII score | log2(13/728*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/1120*10)=-2.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CHI3L1 [Title/Abstract] AND GMDS [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CHI3L1(203148064)-GMDS(2235871), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | GMDS | GO:0019673 | GDP-mannose metabolic process | 9525924 |
Tgene | GMDS | GO:0042351 | 'de novo' GDP-L-fucose biosynthetic process | 9525924 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for CHI3L1-GMDS |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CHI3L1-GMDS |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CHI3L1-GMDS |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:203148064/:2235871) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CHI3L1 | GMDS |
FUNCTION: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:19414556, ECO:0000269|PubMed:20558631, ECO:0000269|PubMed:9492324}. | FUNCTION: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose. {ECO:0000269|PubMed:9525924}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CHI3L1-GMDS |
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Fusion Gene PPI Analysis for CHI3L1-GMDS |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CHI3L1-GMDS |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CHI3L1-GMDS |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CHI3L1 | C0017636 | Glioblastoma | 1 | CTD_human |
Hgene | CHI3L1 | C0017638 | Glioma | 1 | CTD_human |
Hgene | CHI3L1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | CHI3L1 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Hgene | CHI3L1 | C0086743 | Osteoarthrosis Deformans | 1 | CTD_human |
Hgene | CHI3L1 | C0259783 | mixed gliomas | 1 | CTD_human |
Hgene | CHI3L1 | C0334588 | Giant Cell Glioblastoma | 1 | CTD_human |
Hgene | CHI3L1 | C0555198 | Malignant Glioma | 1 | CTD_human |
Hgene | CHI3L1 | C1621958 | Glioblastoma Multiforme | 1 | CTD_human |