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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ADAMTS7-TMEM135 (FusionGDB2 ID:HG11173TG65084) |
Fusion Gene Summary for ADAMTS7-TMEM135 |
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Fusion gene information | Fusion gene name: ADAMTS7-TMEM135 | Fusion gene ID: hg11173tg65084 | Hgene | Tgene | Gene symbol | ADAMTS7 | TMEM135 | Gene ID | 11173 | 65084 |
Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 7 | transmembrane protein 135 | |
Synonyms | ADAM-TS 7|ADAM-TS7|ADAMTS-7 | PMP52 | |
Cytomap | ('ADAMTS7')('TMEM135') 15q25.1 | 11q14.2 | |
Type of gene | protein-coding | protein-coding | |
Description | A disintegrin and metalloproteinase with thrombospondin motifs 7COMPasea disintegrin and metalloprotease with thrombospondin motifs-7 preproproteina disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7 | transmembrane protein 135peroxisomal membrane protein 52 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q9UKP4 | . | |
Ensembl transtripts involved in fusion gene | ENST00000388820, ENST00000566303, | ||
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 11 X 9 X 7=693 |
# samples | 3 | 12 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/693*10)=-2.5298209465287 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ADAMTS7 [Title/Abstract] AND TMEM135 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ADAMTS7(79103463)-TMEM135(86947680), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | ADAMTS7-TMEM135 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADAMTS7-TMEM135 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ADAMTS7 | GO:0032331 | negative regulation of chondrocyte differentiation | 22247065 |
Hgene | ADAMTS7 | GO:0071773 | cellular response to BMP stimulus | 22247065 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SKCM | TCGA-ER-A3ET-06A | ADAMTS7 | chr15 | 79103463 | - | TMEM135 | chr11 | 86947680 | + |
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Fusion Gene ORF analysis for ADAMTS7-TMEM135 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000388820 | ENST00000355734 | ADAMTS7 | chr15 | 79103463 | - | TMEM135 | chr11 | 86947680 | + |
5UTR-3CDS | ENST00000566303 | ENST00000305494 | ADAMTS7 | chr15 | 79103463 | - | TMEM135 | chr11 | 86947680 | + |
5UTR-3CDS | ENST00000566303 | ENST00000340353 | ADAMTS7 | chr15 | 79103463 | - | TMEM135 | chr11 | 86947680 | + |
5UTR-3CDS | ENST00000566303 | ENST00000532959 | ADAMTS7 | chr15 | 79103463 | - | TMEM135 | chr11 | 86947680 | + |
5UTR-3CDS | ENST00000566303 | ENST00000535167 | ADAMTS7 | chr15 | 79103463 | - | TMEM135 | chr11 | 86947680 | + |
5UTR-intron | ENST00000566303 | ENST00000355734 | ADAMTS7 | chr15 | 79103463 | - | TMEM135 | chr11 | 86947680 | + |
In-frame | ENST00000388820 | ENST00000305494 | ADAMTS7 | chr15 | 79103463 | - | TMEM135 | chr11 | 86947680 | + |
In-frame | ENST00000388820 | ENST00000340353 | ADAMTS7 | chr15 | 79103463 | - | TMEM135 | chr11 | 86947680 | + |
In-frame | ENST00000388820 | ENST00000532959 | ADAMTS7 | chr15 | 79103463 | - | TMEM135 | chr11 | 86947680 | + |
In-frame | ENST00000388820 | ENST00000535167 | ADAMTS7 | chr15 | 79103463 | - | TMEM135 | chr11 | 86947680 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000388820 | ADAMTS7 | chr15 | 79103463 | - | ENST00000340353 | TMEM135 | chr11 | 86947680 | + | 3651 | 311 | 101 | 1225 | 374 |
ENST00000388820 | ADAMTS7 | chr15 | 79103463 | - | ENST00000532959 | TMEM135 | chr11 | 86947680 | + | 1252 | 311 | 101 | 1225 | 374 |
ENST00000388820 | ADAMTS7 | chr15 | 79103463 | - | ENST00000305494 | TMEM135 | chr11 | 86947680 | + | 2243 | 311 | 101 | 1225 | 374 |
ENST00000388820 | ADAMTS7 | chr15 | 79103463 | - | ENST00000535167 | TMEM135 | chr11 | 86947680 | + | 1379 | 311 | 101 | 1225 | 374 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000388820 | ENST00000340353 | ADAMTS7 | chr15 | 79103463 | - | TMEM135 | chr11 | 86947680 | + | 0.000531752 | 0.99946827 |
ENST00000388820 | ENST00000532959 | ADAMTS7 | chr15 | 79103463 | - | TMEM135 | chr11 | 86947680 | + | 0.001990194 | 0.99800986 |
ENST00000388820 | ENST00000305494 | ADAMTS7 | chr15 | 79103463 | - | TMEM135 | chr11 | 86947680 | + | 0.000842802 | 0.9991572 |
ENST00000388820 | ENST00000535167 | ADAMTS7 | chr15 | 79103463 | - | TMEM135 | chr11 | 86947680 | + | 0.002021388 | 0.9979786 |
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Fusion Genomic Features for ADAMTS7-TMEM135 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
ADAMTS7 | chr15 | 79103462 | - | TMEM135 | chr11 | 86947679 | + | 0.000920391 | 0.9990796 |
ADAMTS7 | chr15 | 79103462 | - | TMEM135 | chr11 | 86947679 | + | 0.000920391 | 0.9990796 |
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Fusion Protein Features for ADAMTS7-TMEM135 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:79103463/chr11:86947680) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ADAMTS7 | . |
FUNCTION: Metalloprotease that may play a role in the degradation of COMP. {ECO:0000269|PubMed:16585064}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | TMEM135 | chr15:79103463 | chr11:86947680 | ENST00000305494 | 4 | 15 | 298_318 | 154 | 459.0 | Transmembrane | Helical | |
Tgene | TMEM135 | chr15:79103463 | chr11:86947680 | ENST00000305494 | 4 | 15 | 331_351 | 154 | 459.0 | Transmembrane | Helical | |
Tgene | TMEM135 | chr15:79103463 | chr11:86947680 | ENST00000305494 | 4 | 15 | 380_400 | 154 | 459.0 | Transmembrane | Helical | |
Tgene | TMEM135 | chr15:79103463 | chr11:86947680 | ENST00000340353 | 3 | 14 | 149_169 | 132 | 437.0 | Transmembrane | Helical | |
Tgene | TMEM135 | chr15:79103463 | chr11:86947680 | ENST00000340353 | 3 | 14 | 298_318 | 132 | 437.0 | Transmembrane | Helical | |
Tgene | TMEM135 | chr15:79103463 | chr11:86947680 | ENST00000340353 | 3 | 14 | 331_351 | 132 | 437.0 | Transmembrane | Helical | |
Tgene | TMEM135 | chr15:79103463 | chr11:86947680 | ENST00000340353 | 3 | 14 | 380_400 | 132 | 437.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ADAMTS7 | chr15:79103463 | chr11:86947680 | ENST00000388820 | - | 1 | 24 | 595_697 | 33 | 1687.0 | Compositional bias | Note=Cys-rich |
Hgene | ADAMTS7 | chr15:79103463 | chr11:86947680 | ENST00000388820 | - | 1 | 24 | 1411_1459 | 33 | 1687.0 | Domain | TSP type-1 5 |
Hgene | ADAMTS7 | chr15:79103463 | chr11:86947680 | ENST00000388820 | - | 1 | 24 | 1462_1522 | 33 | 1687.0 | Domain | TSP type-1 6 |
Hgene | ADAMTS7 | chr15:79103463 | chr11:86947680 | ENST00000388820 | - | 1 | 24 | 1523_1567 | 33 | 1687.0 | Domain | TSP type-1 7 |
Hgene | ADAMTS7 | chr15:79103463 | chr11:86947680 | ENST00000388820 | - | 1 | 24 | 1569_1629 | 33 | 1687.0 | Domain | TSP type-1 8 |
Hgene | ADAMTS7 | chr15:79103463 | chr11:86947680 | ENST00000388820 | - | 1 | 24 | 1632_1672 | 33 | 1687.0 | Domain | PLAC |
Hgene | ADAMTS7 | chr15:79103463 | chr11:86947680 | ENST00000388820 | - | 1 | 24 | 242_452 | 33 | 1687.0 | Domain | Peptidase M12B |
Hgene | ADAMTS7 | chr15:79103463 | chr11:86947680 | ENST00000388820 | - | 1 | 24 | 462_537 | 33 | 1687.0 | Domain | Note=Disintegrin |
Hgene | ADAMTS7 | chr15:79103463 | chr11:86947680 | ENST00000388820 | - | 1 | 24 | 538_593 | 33 | 1687.0 | Domain | TSP type-1 1 |
Hgene | ADAMTS7 | chr15:79103463 | chr11:86947680 | ENST00000388820 | - | 1 | 24 | 821_880 | 33 | 1687.0 | Domain | TSP type-1 2 |
Hgene | ADAMTS7 | chr15:79103463 | chr11:86947680 | ENST00000388820 | - | 1 | 24 | 881_940 | 33 | 1687.0 | Domain | TSP type-1 3 |
Hgene | ADAMTS7 | chr15:79103463 | chr11:86947680 | ENST00000388820 | - | 1 | 24 | 942_995 | 33 | 1687.0 | Domain | TSP type-1 4 |
Hgene | ADAMTS7 | chr15:79103463 | chr11:86947680 | ENST00000388820 | - | 1 | 24 | 202_209 | 33 | 1687.0 | Motif | Cysteine switch |
Hgene | ADAMTS7 | chr15:79103463 | chr11:86947680 | ENST00000388820 | - | 1 | 24 | 698_809 | 33 | 1687.0 | Region | Note=Spacer |
Tgene | TMEM135 | chr15:79103463 | chr11:86947680 | ENST00000305494 | 4 | 15 | 149_169 | 154 | 459.0 | Transmembrane | Helical | |
Tgene | TMEM135 | chr15:79103463 | chr11:86947680 | ENST00000305494 | 4 | 15 | 68_88 | 154 | 459.0 | Transmembrane | Helical | |
Tgene | TMEM135 | chr15:79103463 | chr11:86947680 | ENST00000305494 | 4 | 15 | 96_116 | 154 | 459.0 | Transmembrane | Helical | |
Tgene | TMEM135 | chr15:79103463 | chr11:86947680 | ENST00000340353 | 3 | 14 | 68_88 | 132 | 437.0 | Transmembrane | Helical | |
Tgene | TMEM135 | chr15:79103463 | chr11:86947680 | ENST00000340353 | 3 | 14 | 96_116 | 132 | 437.0 | Transmembrane | Helical |
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Fusion Gene Sequence for ADAMTS7-TMEM135 |
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>2107_2107_1_ADAMTS7-TMEM135_ADAMTS7_chr15_79103463_ENST00000388820_TMEM135_chr11_86947680_ENST00000305494_length(transcript)=2243nt_BP=311nt CTTTTCTTTGCCTCTGCAGCGGCCAAGGGGGCGGGCCCTGCAGCCTTTGTTGCCCGCGGACCGAGCGCAGCCGAACGGAGTCGGGGCCGG GTCGCCGGGAGCTGCACGCCGGCCGGGCATGTCCTGAGCCGGACCTGGGACCAGGCAGCGACCGGACGGGACGGACGAGAGCGTGCGCGC GGGGTCACCCGGCGGCCGCCCGGTTCCTGCCATGCCCGGCGGCCCCAGTCCCCGCAGCCCCGCGCCTTTGCTGCGCCCCCTCCTCCTGCT CCTCTGCGCTCTGGCTCCCGGCGCCCCCGGACCCGCACCAGGTCCTTTTGTTTTGCATCACAGCTGCCATGTACATGTTCTTTTTCAGGT GCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGGTTCATTGTAGGGAAGGAAGAAATTCCCACACATTCTTTTTCACCAGAGG CAGCATATGCAAAAGTGGAACAAAAGAGAGAGCAACATGAGGAAAAACCCGGAAGAATGAATATGATTGGTCTAGTCAGGAAATTTGTGG ATTCAATATGCAAACATGGACCAAGGCATAGATGTTGCAAACATTATGAAGATAATTGCATCTCTTATTGCATTAAAGGTTTCATCAGAA TGTTTAGCGTGGGGTACTTGATCCAGTGCTGCCTCCGAATCCCTTCTGCATTTAGGCATCTGTTTACACAGCCATCTCGGCTACTTTCTC TCTTCTACAATAAAGAAAACTTCCAGCTTGGAGCTTTTCTTGGCTCTTTTGTTAGTATATACAAGGGTACTAGTTGCTTCCTGCGCTGGA TCAGAAACTTAGATGATGAACTACATGCTATTATAGCTGGATTTTTGGCAGGTATATCAATGATGTTTTATAAAAGCACAACAATTTCCA TGTATTTAGCGTCCAAATTGGTAGAGACAATGTATTTCAAAGGCATTGAAGCAGGGAAGGTTCCCTATTTTCCTCATGCAGATACTATCA TCTATTCCATCTCTACAGCAATTTGCTTCCAGGCAGCTGTCATGGAAGTTCAGACTTTGAGACCATCTTACTGGAAGTTCCTTTTAAGAC TCACCAAGGGCAAATTTGCTGTCATGAACCGAAAAGTCCTTGATGTTTTTGGTACTGGTGCATCTAAACACTTTCAGGATTTCATCCCCA GGTTGGATCCAAGATACACAACTGTAACACCAGAGTTGCCCACAGAGTTTTCCTGAAGATGACTGTAACTTATTAATGTGACTAAATGTT TCATCTTGAAGAGTTAATTATGTTGAACACAAAGGAGGGGGCCCAAGCTCGAACTTCAGTGTTATTTCAGTTAGAGATACTCTTTTCATT TGTTTTGTTTTTCTTATGAATCAGAAATTCAGAAGCTTTTTAGGAAGATGTTGCTTAATAATTAAGCTTCCTCCATAGCCAGAATAAGAT TCTGGATCACTGTAGTGACTGACATTATATATTATTGATCAAATTATGTCCACAAGCAATATTATATAATCTACGTAGAAGTGTAATAAC AAACAAGAGTACACTTAAAATTACTTTAAAAGATGTCTTTAGTTCATTCCAATATAATTCTTGATTAAAATTAGGATTATTTCTACATTT TAGGATTTACAAAGGATCACGGGTACATGGATTTGGTCTATATATTTTTTTAAAGTTTTGAATTGGTATCTGTAGTAGTGGAATGTTATA GATTTGAAGTAACTCTCCACGGACAGTGCTGCTTTCGTGTAGAGCAATTTAATTGGAGAAGTGGCCATTCTTACTTCAGGGATGCAAAGA TGGGTCTCATACCATTTGGATAAATGTCGTGGTATCCATGCTTTTTTTCAACTAATAACATCATCTCTCTTCATGACCAGTTAATTGGGC TATTTGGCAGCCCAGTGAACCTATGTACTAATGGCAAGTTAGGGGCAAATGGAAATGGACACATCCGATAAAGTTGAAATGTATGTTTTA ATCTTTCACAGAAGTATTACACTTGAATATTTAAAAACAAAACTTTTAAACTTCCTATAGGTTTATGATGTTTGTTTTCATTTATATGGA CATAATCCTTCATAGCTCAGTTTATATGCCATTGTTGTATTAGAAGGGATCAAAATCCTATGGAACAAAGTAGTCTTGGCAAGTTGGCAG >2107_2107_1_ADAMTS7-TMEM135_ADAMTS7_chr15_79103463_ENST00000388820_TMEM135_chr11_86947680_ENST00000305494_length(amino acids)=374AA_BP=69 MHAGRACPEPDLGPGSDRTGRTRACARGHPAAARFLPCPAAPVPAAPRLCCAPSSCSSALWLPAPPDPHQVLLFCITAAMYMFFFRCKDG LKGFTFSALRFIVGKEEIPTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSV GYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLA SKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGKFAVMNRKVLDVFGTGASKHFQDFIPRLDP -------------------------------------------------------------- >2107_2107_2_ADAMTS7-TMEM135_ADAMTS7_chr15_79103463_ENST00000388820_TMEM135_chr11_86947680_ENST00000340353_length(transcript)=3651nt_BP=311nt CTTTTCTTTGCCTCTGCAGCGGCCAAGGGGGCGGGCCCTGCAGCCTTTGTTGCCCGCGGACCGAGCGCAGCCGAACGGAGTCGGGGCCGG GTCGCCGGGAGCTGCACGCCGGCCGGGCATGTCCTGAGCCGGACCTGGGACCAGGCAGCGACCGGACGGGACGGACGAGAGCGTGCGCGC GGGGTCACCCGGCGGCCGCCCGGTTCCTGCCATGCCCGGCGGCCCCAGTCCCCGCAGCCCCGCGCCTTTGCTGCGCCCCCTCCTCCTGCT CCTCTGCGCTCTGGCTCCCGGCGCCCCCGGACCCGCACCAGGTCCTTTTGTTTTGCATCACAGCTGCCATGTACATGTTCTTTTTCAGGT GCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGGTTCATTGTAGGGAAGGAAGAAATTCCCACACATTCTTTTTCACCAGAGG CAGCATATGCAAAAGTGGAACAAAAGAGAGAGCAACATGAGGAAAAACCCGGAAGAATGAATATGATTGGTCTAGTCAGGAAATTTGTGG ATTCAATATGCAAACATGGACCAAGGCATAGATGTTGCAAACATTATGAAGATAATTGCATCTCTTATTGCATTAAAGGTTTCATCAGAA TGTTTAGCGTGGGGTACTTGATCCAGTGCTGCCTCCGAATCCCTTCTGCATTTAGGCATCTGTTTACACAGCCATCTCGGCTACTTTCTC TCTTCTACAATAAAGAAAACTTCCAGCTTGGAGCTTTTCTTGGCTCTTTTGTTAGTATATACAAGGGTACTAGTTGCTTCCTGCGCTGGA TCAGAAACTTAGATGATGAACTACATGCTATTATAGCTGGATTTTTGGCAGGTATATCAATGATGTTTTATAAAAGCACAACAATTTCCA TGTATTTAGCGTCCAAATTGGTAGAGACAATGTATTTCAAAGGCATTGAAGCAGGGAAGGTTCCCTATTTTCCTCATGCAGATACTATCA TCTATTCCATCTCTACAGCAATTTGCTTCCAGGCAGCTGTCATGGAAGTTCAGACTTTGAGACCATCTTACTGGAAGTTCCTTTTAAGAC TCACCAAGGGCAAATTTGCTGTCATGAACCGAAAAGTCCTTGATGTTTTTGGTACTGGTGCATCTAAACACTTTCAGGATTTCATCCCCA GGTTGGATCCAAGATACACAACTGTAACACCAGAGTTGCCCACAGAGTTTTCCTGAAGATGACTGTAACTTATTAATGTGACTAAATGTT TCATCTTGAAGAGTTAATTATGTTGAACACAAAGGAGGGGGCCCAAGCTCGAACTTCAGTGTTATTTCAGTTAGAGATACTCTTTTCATT TGTTTTGTTTTTCTTATGAATCAGAAATTCAGAAGCTTTTTAGGAAGATGTTGCTTAATAATTAAGCTTCCTCCATAGCCAGAATAAGAT TCTGGATCACTGTAGTGACTGACATTATATATTATTGATCAAATTATGTCCACAAGCAATATTATATAATCTACGTAGAAGTGTAATAAC AAACAAGAGTACACTTAAAATTACTTTAAAAGATGTCTTTAGTTCATTCCAATATAATTCTTGATTAAAATTAGGATTATTTCTACATTT TAGGATTTACAAAGGATCACGGGTACATGGATTTGGTCTATATATTTTTTTAAAGTTTTGAATTGGTATCTGTAGTAGTGGAATGTTATA GATTTGAAGTAACTCTCCACGGACAGTGCTGCTTTCGTGTAGAGCAATTTAATTGGAGAAGTGGCCATTCTTACTTCAGGGATGCAAAGA TGGGTCTCATACCATTTGGATAAATGTCGTGGTATCCATGCTTTTTTTCAACTAATAACATCATCTCTCTTCATGACCAGTTAATTGGGC TATTTGGCAGCCCAGTGAACCTATGTACTAATGGCAAGTTAGGGGCAAATGGAAATGGACACATCCGATAAAGTTGAAATGTATGTTTTA ATCTTTCACAGAAGTATTACACTTGAATATTTAAAAACAAAACTTTTAAACTTCCTATAGGTTTATGATGTTTGTTTTCATTTATATGGA CATAATCCTTCATAGCTCAGTTTATATGCCATTGTTGTATTAGAAGGGATCAAAATCCTATGGAACAAAGTAGTCTTGGCAAGTTGGCAG TTTGTGTCCTCTCAGCTGTTTAACTTATGTAATGGATGTTTTGCACCTGAAAACACTATAAAAATCCAGTGGTTGTTTAAAAAGTCCATT TGTCACTAATTCCATTCAGGTTCTCCAACCTTCTTCTTGAATATCATTGTCACCATTTTTACTGTTAGAATAAAGAGGTGACACCATAAA GTCCTGCTGATAATGAGAGTAGTTCAGGACAGCTGTGATTGAAATATGGTCGCTATTTACAGTTTTTCAGGGAAAAGTTATACTTTTCTA TGTTAATAAAGAGCTGAAGTGGTCTACAGTTAATGTGACATGTAGGGATGATGATATTTTTAAAATACATTTTGTTGCTAAAAAGTTTTT AGGCCAGTGCAAATTATGCAGTAGAACTTGTGTTGCAAAAGGAATTATAACCCATACTTTAAAAATGCTTAATCCCTCATATTCAATTTC ATCAAGCCTTGTATACTTCTGCTTAAATGTAATTCAATCCTTGGTTGTTATGGCAAACAGAAACCCAACAAAAAGACAGACTCTGGTACT ATGGTAACAGAGCCACTTTATCATTTGGTCAAAATTTGGCATTATGATTAGCTTTGTAGAACTGACCTGTTTATTTGGCAATGCTGTTAA AGGATCATTTCGGTTTCAGACTTCAAAGTTGATTAATAAATTTAATCTTAACTTTTTATTCACTGGAATCAAAACGATGGTTGGTACTGT GTTTACTGTTTAAAATGAAGTACTAAAGCCCTGAGAACTGCACCTCATTTTCTTTATCCAGAAATTGTGCTTATATATTTTCCTGTCAGG TTTAAAAAGATGTTTTAATTCATAAATTATTGTTTTCATTGACATTAAAAGACTGTGATATTGAAAGATGAATTACGAAATTTGCTGAGA TTGTTTAGTAAAATTTTGCTGGTCAAAAAGGTGTATTTCTACAATTTACCTTTTCATTTTTATAAATTGCAGTCATTTTTTTAAATTTTA TGTAAAATGTAAAATGAAATAGCTATCATGAAGCAGAATACAATGATGAATGTATAGGTTGAGTGAATAACCAATTTGCAGTGGTGGATT GAGAAGTCCAGTTTGATTTCATTGGGACAGACTGCAAAGTGTAGTTGTTTGAGCAAACACAAAGAAACTTTGTGTTTTTGAAGACAATCA GAATGATTACCTTTCTACCTCTAACTAATCAGGTATTGATTGACAACTTTTTGGCATTATAAATAAAGTAAAATAGATCTCTGCATTCCA AAATATGTTTTTTAGTTTATTTATATCCTGAAGAAATGGTAAGTTTTCACTGGAACTGATTACAGTAAACAATAATATGTCCCCTTAGTC TTTCTGACATTTTTATATAGATTGAGATTGAAAAACCGTGCATTTGGGGCAGTGGTATTATGGTCATTTCGTTGCTATTTTCTGTTTTAA >2107_2107_2_ADAMTS7-TMEM135_ADAMTS7_chr15_79103463_ENST00000388820_TMEM135_chr11_86947680_ENST00000340353_length(amino acids)=374AA_BP=69 MHAGRACPEPDLGPGSDRTGRTRACARGHPAAARFLPCPAAPVPAAPRLCCAPSSCSSALWLPAPPDPHQVLLFCITAAMYMFFFRCKDG LKGFTFSALRFIVGKEEIPTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSV GYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLA SKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGKFAVMNRKVLDVFGTGASKHFQDFIPRLDP -------------------------------------------------------------- >2107_2107_3_ADAMTS7-TMEM135_ADAMTS7_chr15_79103463_ENST00000388820_TMEM135_chr11_86947680_ENST00000532959_length(transcript)=1252nt_BP=311nt CTTTTCTTTGCCTCTGCAGCGGCCAAGGGGGCGGGCCCTGCAGCCTTTGTTGCCCGCGGACCGAGCGCAGCCGAACGGAGTCGGGGCCGG GTCGCCGGGAGCTGCACGCCGGCCGGGCATGTCCTGAGCCGGACCTGGGACCAGGCAGCGACCGGACGGGACGGACGAGAGCGTGCGCGC GGGGTCACCCGGCGGCCGCCCGGTTCCTGCCATGCCCGGCGGCCCCAGTCCCCGCAGCCCCGCGCCTTTGCTGCGCCCCCTCCTCCTGCT CCTCTGCGCTCTGGCTCCCGGCGCCCCCGGACCCGCACCAGGTCCTTTTGTTTTGCATCACAGCTGCCATGTACATGTTCTTTTTCAGGT GCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGGTTCATTGTAGGGAAGGAAGAAATTCCCACACATTCTTTTTCACCAGAGG CAGCATATGCAAAAGTGGAACAAAAGAGAGAGCAACATGAGGAAAAACCCGGAAGAATGAATATGATTGGTCTAGTCAGGAAATTTGTGG ATTCAATATGCAAACATGGACCAAGGCATAGATGTTGCAAACATTATGAAGATAATTGCATCTCTTATTGCATTAAAGGTTTCATCAGAA TGTTTAGCGTGGGGTACTTGATCCAGTGCTGCCTCCGAATCCCTTCTGCATTTAGGCATCTGTTTACACAGCCATCTCGGCTACTTTCTC TCTTCTACAATAAAGAAAACTTCCAGCTTGGAGCTTTTCTTGGCTCTTTTGTTAGTATATACAAGGGTACTAGTTGCTTCCTGCGCTGGA TCAGAAACTTAGATGATGAACTACATGCTATTATAGCTGGATTTTTGGCAGGTATATCAATGATGTTTTATAAAAGCACAACAATTTCCA TGTATTTAGCGTCCAAATTGGTAGAGACAATGTATTTCAAAGGCATTGAAGCAGGGAAGGTTCCCTATTTTCCTCATGCAGATACTATCA TCTATTCCATCTCTACAGCAATTTGCTTCCAGGCAGCTGTCATGGAAGTTCAGACTTTGAGACCATCTTACTGGAAGTTCCTTTTAAGAC TCACCAAGGGCAAATTTGCTGTCATGAACCGAAAAGTCCTTGATGTTTTTGGTACTGGTGCATCTAAACACTTTCAGGATTTCATCCCCA >2107_2107_3_ADAMTS7-TMEM135_ADAMTS7_chr15_79103463_ENST00000388820_TMEM135_chr11_86947680_ENST00000532959_length(amino acids)=374AA_BP=69 MHAGRACPEPDLGPGSDRTGRTRACARGHPAAARFLPCPAAPVPAAPRLCCAPSSCSSALWLPAPPDPHQVLLFCITAAMYMFFFRCKDG LKGFTFSALRFIVGKEEIPTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSV GYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLA SKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGKFAVMNRKVLDVFGTGASKHFQDFIPRLDP -------------------------------------------------------------- >2107_2107_4_ADAMTS7-TMEM135_ADAMTS7_chr15_79103463_ENST00000388820_TMEM135_chr11_86947680_ENST00000535167_length(transcript)=1379nt_BP=311nt CTTTTCTTTGCCTCTGCAGCGGCCAAGGGGGCGGGCCCTGCAGCCTTTGTTGCCCGCGGACCGAGCGCAGCCGAACGGAGTCGGGGCCGG GTCGCCGGGAGCTGCACGCCGGCCGGGCATGTCCTGAGCCGGACCTGGGACCAGGCAGCGACCGGACGGGACGGACGAGAGCGTGCGCGC GGGGTCACCCGGCGGCCGCCCGGTTCCTGCCATGCCCGGCGGCCCCAGTCCCCGCAGCCCCGCGCCTTTGCTGCGCCCCCTCCTCCTGCT CCTCTGCGCTCTGGCTCCCGGCGCCCCCGGACCCGCACCAGGTCCTTTTGTTTTGCATCACAGCTGCCATGTACATGTTCTTTTTCAGGT GCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGGTTCATTGTAGGGAAGGAAGAAATTCCCACACATTCTTTTTCACCAGAGG CAGCATATGCAAAAGTGGAACAAAAGAGAGAGCAACATGAGGAAAAACCCGGAAGAATGAATATGATTGGTCTAGTCAGGAAATTTGTGG ATTCAATATGCAAACATGGACCAAGGCATAGATGTTGCAAACATTATGAAGATAATTGCATCTCTTATTGCATTAAAGGTTTCATCAGAA TGTTTAGCGTGGGGTACTTGATCCAGTGCTGCCTCCGAATCCCTTCTGCATTTAGGCATCTGTTTACACAGCCATCTCGGCTACTTTCTC TCTTCTACAATAAAGAAAACTTCCAGCTTGGAGCTTTTCTTGGCTCTTTTGTTAGTATATACAAGGGTACTAGTTGCTTCCTGCGCTGGA TCAGAAACTTAGATGATGAACTACATGCTATTATAGCTGGATTTTTGGCAGGTATATCAATGATGTTTTATAAAAGCACAACAATTTCCA TGTATTTAGCGTCCAAATTGGTAGAGACAATGTATTTCAAAGGCATTGAAGCAGGGAAGGTTCCCTATTTTCCTCATGCAGATACTATCA TCTATTCCATCTCTACAGCAATTTGCTTCCAGGCAGCTGTCATGGAAGTTCAGACTTTGAGACCATCTTACTGGAAGTTCCTTTTAAGAC TCACCAAGGGCAAATTTGCTGTCATGAACCGAAAAGTCCTTGATGTTTTTGGTACTGGTGCATCTAAACACTTTCAGGATTTCATCCCCA GGTTGGATCCAAGATACACAACTGTAACACCAGAGTTGCCCACAGAGTTTTCCTGAAGATGACTGTAACTTATTAATGTGACTAAATGTT TCATCTTGAAGAGTTAATTATGTTGAACACAAAGGAGGGGGCCCAAGCTCGAACTTCAGTGTTATTTCAGTTAGAGATACTCTTTTCATT >2107_2107_4_ADAMTS7-TMEM135_ADAMTS7_chr15_79103463_ENST00000388820_TMEM135_chr11_86947680_ENST00000535167_length(amino acids)=374AA_BP=69 MHAGRACPEPDLGPGSDRTGRTRACARGHPAAARFLPCPAAPVPAAPRLCCAPSSCSSALWLPAPPDPHQVLLFCITAAMYMFFFRCKDG LKGFTFSALRFIVGKEEIPTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSV GYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLA SKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGKFAVMNRKVLDVFGTGASKHFQDFIPRLDP -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ADAMTS7-TMEM135 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ADAMTS7-TMEM135 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ADAMTS7-TMEM135 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ADAMTS7 | C0010054 | Coronary Arteriosclerosis | 1 | CTD_human |
Hgene | ADAMTS7 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Hgene | ADAMTS7 | C1136382 | Sclerocystic Ovaries | 1 | CTD_human |
Hgene | ADAMTS7 | C1956346 | Coronary Artery Disease | 1 | CTD_human |
Tgene | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human | |
Tgene | C0017636 | Glioblastoma | 1 | CTD_human | |
Tgene | C0020796 | Profound Mental Retardation | 1 | CTD_human | |
Tgene | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human | |
Tgene | C0334588 | Giant Cell Glioblastoma | 1 | CTD_human | |
Tgene | C0917816 | Mental deficiency | 1 | CTD_human | |
Tgene | C1621958 | Glioblastoma Multiforme | 1 | CTD_human | |
Tgene | C3714756 | Intellectual Disability | 1 | CTD_human |