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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADAMTS7-TMEM135 (FusionGDB2 ID:HG11173TG65084)

Fusion Gene Summary for ADAMTS7-TMEM135

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAMTS7-TMEM135
Fusion gene ID: hg11173tg65084
HgeneTgene
Gene symbol

ADAMTS7

TMEM135

Gene ID

11173

65084

Gene nameADAM metallopeptidase with thrombospondin type 1 motif 7transmembrane protein 135
SynonymsADAM-TS 7|ADAM-TS7|ADAMTS-7PMP52
Cytomap('ADAMTS7')('TMEM135')

15q25.1

11q14.2

Type of geneprotein-codingprotein-coding
DescriptionA disintegrin and metalloproteinase with thrombospondin motifs 7COMPasea disintegrin and metalloprotease with thrombospondin motifs-7 preproproteina disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7transmembrane protein 135peroxisomal membrane protein 52
Modification date2020031320200313
UniProtAcc

Q9UKP4

.
Ensembl transtripts involved in fusion geneENST00000388820, ENST00000566303, 
Fusion gene scores* DoF score3 X 3 X 3=2711 X 9 X 7=693
# samples 312
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(12/693*10)=-2.5298209465287
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAMTS7 [Title/Abstract] AND TMEM135 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADAMTS7(79103463)-TMEM135(86947680), # samples:3
Anticipated loss of major functional domain due to fusion event.ADAMTS7-TMEM135 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS7-TMEM135 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAMTS7

GO:0032331

negative regulation of chondrocyte differentiation

22247065

HgeneADAMTS7

GO:0071773

cellular response to BMP stimulus

22247065


check buttonFusion gene breakpoints across ADAMTS7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TMEM135 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-ER-A3ET-06AADAMTS7chr15

79103463

-TMEM135chr11

86947680

+


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Fusion Gene ORF analysis for ADAMTS7-TMEM135

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000388820ENST00000355734ADAMTS7chr15

79103463

-TMEM135chr11

86947680

+
5UTR-3CDSENST00000566303ENST00000305494ADAMTS7chr15

79103463

-TMEM135chr11

86947680

+
5UTR-3CDSENST00000566303ENST00000340353ADAMTS7chr15

79103463

-TMEM135chr11

86947680

+
5UTR-3CDSENST00000566303ENST00000532959ADAMTS7chr15

79103463

-TMEM135chr11

86947680

+
5UTR-3CDSENST00000566303ENST00000535167ADAMTS7chr15

79103463

-TMEM135chr11

86947680

+
5UTR-intronENST00000566303ENST00000355734ADAMTS7chr15

79103463

-TMEM135chr11

86947680

+
In-frameENST00000388820ENST00000305494ADAMTS7chr15

79103463

-TMEM135chr11

86947680

+
In-frameENST00000388820ENST00000340353ADAMTS7chr15

79103463

-TMEM135chr11

86947680

+
In-frameENST00000388820ENST00000532959ADAMTS7chr15

79103463

-TMEM135chr11

86947680

+
In-frameENST00000388820ENST00000535167ADAMTS7chr15

79103463

-TMEM135chr11

86947680

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000388820ADAMTS7chr1579103463-ENST00000340353TMEM135chr1186947680+36513111011225374
ENST00000388820ADAMTS7chr1579103463-ENST00000532959TMEM135chr1186947680+12523111011225374
ENST00000388820ADAMTS7chr1579103463-ENST00000305494TMEM135chr1186947680+22433111011225374
ENST00000388820ADAMTS7chr1579103463-ENST00000535167TMEM135chr1186947680+13793111011225374

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000388820ENST00000340353ADAMTS7chr1579103463-TMEM135chr1186947680+0.0005317520.99946827
ENST00000388820ENST00000532959ADAMTS7chr1579103463-TMEM135chr1186947680+0.0019901940.99800986
ENST00000388820ENST00000305494ADAMTS7chr1579103463-TMEM135chr1186947680+0.0008428020.9991572
ENST00000388820ENST00000535167ADAMTS7chr1579103463-TMEM135chr1186947680+0.0020213880.9979786

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Fusion Genomic Features for ADAMTS7-TMEM135


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ADAMTS7chr1579103462-TMEM135chr1186947679+0.0009203910.9990796
ADAMTS7chr1579103462-TMEM135chr1186947679+0.0009203910.9990796

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ADAMTS7-TMEM135


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:79103463/chr11:86947680)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAMTS7

Q9UKP4

.
FUNCTION: Metalloprotease that may play a role in the degradation of COMP. {ECO:0000269|PubMed:16585064}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMEM135chr15:79103463chr11:86947680ENST00000305494415298_318154459.0TransmembraneHelical
TgeneTMEM135chr15:79103463chr11:86947680ENST00000305494415331_351154459.0TransmembraneHelical
TgeneTMEM135chr15:79103463chr11:86947680ENST00000305494415380_400154459.0TransmembraneHelical
TgeneTMEM135chr15:79103463chr11:86947680ENST00000340353314149_169132437.0TransmembraneHelical
TgeneTMEM135chr15:79103463chr11:86947680ENST00000340353314298_318132437.0TransmembraneHelical
TgeneTMEM135chr15:79103463chr11:86947680ENST00000340353314331_351132437.0TransmembraneHelical
TgeneTMEM135chr15:79103463chr11:86947680ENST00000340353314380_400132437.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAMTS7chr15:79103463chr11:86947680ENST00000388820-124595_697331687.0Compositional biasNote=Cys-rich
HgeneADAMTS7chr15:79103463chr11:86947680ENST00000388820-1241411_1459331687.0DomainTSP type-1 5
HgeneADAMTS7chr15:79103463chr11:86947680ENST00000388820-1241462_1522331687.0DomainTSP type-1 6
HgeneADAMTS7chr15:79103463chr11:86947680ENST00000388820-1241523_1567331687.0DomainTSP type-1 7
HgeneADAMTS7chr15:79103463chr11:86947680ENST00000388820-1241569_1629331687.0DomainTSP type-1 8
HgeneADAMTS7chr15:79103463chr11:86947680ENST00000388820-1241632_1672331687.0DomainPLAC
HgeneADAMTS7chr15:79103463chr11:86947680ENST00000388820-124242_452331687.0DomainPeptidase M12B
HgeneADAMTS7chr15:79103463chr11:86947680ENST00000388820-124462_537331687.0DomainNote=Disintegrin
HgeneADAMTS7chr15:79103463chr11:86947680ENST00000388820-124538_593331687.0DomainTSP type-1 1
HgeneADAMTS7chr15:79103463chr11:86947680ENST00000388820-124821_880331687.0DomainTSP type-1 2
HgeneADAMTS7chr15:79103463chr11:86947680ENST00000388820-124881_940331687.0DomainTSP type-1 3
HgeneADAMTS7chr15:79103463chr11:86947680ENST00000388820-124942_995331687.0DomainTSP type-1 4
HgeneADAMTS7chr15:79103463chr11:86947680ENST00000388820-124202_209331687.0MotifCysteine switch
HgeneADAMTS7chr15:79103463chr11:86947680ENST00000388820-124698_809331687.0RegionNote=Spacer
TgeneTMEM135chr15:79103463chr11:86947680ENST00000305494415149_169154459.0TransmembraneHelical
TgeneTMEM135chr15:79103463chr11:86947680ENST0000030549441568_88154459.0TransmembraneHelical
TgeneTMEM135chr15:79103463chr11:86947680ENST0000030549441596_116154459.0TransmembraneHelical
TgeneTMEM135chr15:79103463chr11:86947680ENST0000034035331468_88132437.0TransmembraneHelical
TgeneTMEM135chr15:79103463chr11:86947680ENST0000034035331496_116132437.0TransmembraneHelical


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Fusion Gene Sequence for ADAMTS7-TMEM135


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2107_2107_1_ADAMTS7-TMEM135_ADAMTS7_chr15_79103463_ENST00000388820_TMEM135_chr11_86947680_ENST00000305494_length(transcript)=2243nt_BP=311nt
CTTTTCTTTGCCTCTGCAGCGGCCAAGGGGGCGGGCCCTGCAGCCTTTGTTGCCCGCGGACCGAGCGCAGCCGAACGGAGTCGGGGCCGG
GTCGCCGGGAGCTGCACGCCGGCCGGGCATGTCCTGAGCCGGACCTGGGACCAGGCAGCGACCGGACGGGACGGACGAGAGCGTGCGCGC
GGGGTCACCCGGCGGCCGCCCGGTTCCTGCCATGCCCGGCGGCCCCAGTCCCCGCAGCCCCGCGCCTTTGCTGCGCCCCCTCCTCCTGCT
CCTCTGCGCTCTGGCTCCCGGCGCCCCCGGACCCGCACCAGGTCCTTTTGTTTTGCATCACAGCTGCCATGTACATGTTCTTTTTCAGGT
GCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGGTTCATTGTAGGGAAGGAAGAAATTCCCACACATTCTTTTTCACCAGAGG
CAGCATATGCAAAAGTGGAACAAAAGAGAGAGCAACATGAGGAAAAACCCGGAAGAATGAATATGATTGGTCTAGTCAGGAAATTTGTGG
ATTCAATATGCAAACATGGACCAAGGCATAGATGTTGCAAACATTATGAAGATAATTGCATCTCTTATTGCATTAAAGGTTTCATCAGAA
TGTTTAGCGTGGGGTACTTGATCCAGTGCTGCCTCCGAATCCCTTCTGCATTTAGGCATCTGTTTACACAGCCATCTCGGCTACTTTCTC
TCTTCTACAATAAAGAAAACTTCCAGCTTGGAGCTTTTCTTGGCTCTTTTGTTAGTATATACAAGGGTACTAGTTGCTTCCTGCGCTGGA
TCAGAAACTTAGATGATGAACTACATGCTATTATAGCTGGATTTTTGGCAGGTATATCAATGATGTTTTATAAAAGCACAACAATTTCCA
TGTATTTAGCGTCCAAATTGGTAGAGACAATGTATTTCAAAGGCATTGAAGCAGGGAAGGTTCCCTATTTTCCTCATGCAGATACTATCA
TCTATTCCATCTCTACAGCAATTTGCTTCCAGGCAGCTGTCATGGAAGTTCAGACTTTGAGACCATCTTACTGGAAGTTCCTTTTAAGAC
TCACCAAGGGCAAATTTGCTGTCATGAACCGAAAAGTCCTTGATGTTTTTGGTACTGGTGCATCTAAACACTTTCAGGATTTCATCCCCA
GGTTGGATCCAAGATACACAACTGTAACACCAGAGTTGCCCACAGAGTTTTCCTGAAGATGACTGTAACTTATTAATGTGACTAAATGTT
TCATCTTGAAGAGTTAATTATGTTGAACACAAAGGAGGGGGCCCAAGCTCGAACTTCAGTGTTATTTCAGTTAGAGATACTCTTTTCATT
TGTTTTGTTTTTCTTATGAATCAGAAATTCAGAAGCTTTTTAGGAAGATGTTGCTTAATAATTAAGCTTCCTCCATAGCCAGAATAAGAT
TCTGGATCACTGTAGTGACTGACATTATATATTATTGATCAAATTATGTCCACAAGCAATATTATATAATCTACGTAGAAGTGTAATAAC
AAACAAGAGTACACTTAAAATTACTTTAAAAGATGTCTTTAGTTCATTCCAATATAATTCTTGATTAAAATTAGGATTATTTCTACATTT
TAGGATTTACAAAGGATCACGGGTACATGGATTTGGTCTATATATTTTTTTAAAGTTTTGAATTGGTATCTGTAGTAGTGGAATGTTATA
GATTTGAAGTAACTCTCCACGGACAGTGCTGCTTTCGTGTAGAGCAATTTAATTGGAGAAGTGGCCATTCTTACTTCAGGGATGCAAAGA
TGGGTCTCATACCATTTGGATAAATGTCGTGGTATCCATGCTTTTTTTCAACTAATAACATCATCTCTCTTCATGACCAGTTAATTGGGC
TATTTGGCAGCCCAGTGAACCTATGTACTAATGGCAAGTTAGGGGCAAATGGAAATGGACACATCCGATAAAGTTGAAATGTATGTTTTA
ATCTTTCACAGAAGTATTACACTTGAATATTTAAAAACAAAACTTTTAAACTTCCTATAGGTTTATGATGTTTGTTTTCATTTATATGGA
CATAATCCTTCATAGCTCAGTTTATATGCCATTGTTGTATTAGAAGGGATCAAAATCCTATGGAACAAAGTAGTCTTGGCAAGTTGGCAG

>2107_2107_1_ADAMTS7-TMEM135_ADAMTS7_chr15_79103463_ENST00000388820_TMEM135_chr11_86947680_ENST00000305494_length(amino acids)=374AA_BP=69
MHAGRACPEPDLGPGSDRTGRTRACARGHPAAARFLPCPAAPVPAAPRLCCAPSSCSSALWLPAPPDPHQVLLFCITAAMYMFFFRCKDG
LKGFTFSALRFIVGKEEIPTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSV
GYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLA
SKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGKFAVMNRKVLDVFGTGASKHFQDFIPRLDP

--------------------------------------------------------------
>2107_2107_2_ADAMTS7-TMEM135_ADAMTS7_chr15_79103463_ENST00000388820_TMEM135_chr11_86947680_ENST00000340353_length(transcript)=3651nt_BP=311nt
CTTTTCTTTGCCTCTGCAGCGGCCAAGGGGGCGGGCCCTGCAGCCTTTGTTGCCCGCGGACCGAGCGCAGCCGAACGGAGTCGGGGCCGG
GTCGCCGGGAGCTGCACGCCGGCCGGGCATGTCCTGAGCCGGACCTGGGACCAGGCAGCGACCGGACGGGACGGACGAGAGCGTGCGCGC
GGGGTCACCCGGCGGCCGCCCGGTTCCTGCCATGCCCGGCGGCCCCAGTCCCCGCAGCCCCGCGCCTTTGCTGCGCCCCCTCCTCCTGCT
CCTCTGCGCTCTGGCTCCCGGCGCCCCCGGACCCGCACCAGGTCCTTTTGTTTTGCATCACAGCTGCCATGTACATGTTCTTTTTCAGGT
GCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGGTTCATTGTAGGGAAGGAAGAAATTCCCACACATTCTTTTTCACCAGAGG
CAGCATATGCAAAAGTGGAACAAAAGAGAGAGCAACATGAGGAAAAACCCGGAAGAATGAATATGATTGGTCTAGTCAGGAAATTTGTGG
ATTCAATATGCAAACATGGACCAAGGCATAGATGTTGCAAACATTATGAAGATAATTGCATCTCTTATTGCATTAAAGGTTTCATCAGAA
TGTTTAGCGTGGGGTACTTGATCCAGTGCTGCCTCCGAATCCCTTCTGCATTTAGGCATCTGTTTACACAGCCATCTCGGCTACTTTCTC
TCTTCTACAATAAAGAAAACTTCCAGCTTGGAGCTTTTCTTGGCTCTTTTGTTAGTATATACAAGGGTACTAGTTGCTTCCTGCGCTGGA
TCAGAAACTTAGATGATGAACTACATGCTATTATAGCTGGATTTTTGGCAGGTATATCAATGATGTTTTATAAAAGCACAACAATTTCCA
TGTATTTAGCGTCCAAATTGGTAGAGACAATGTATTTCAAAGGCATTGAAGCAGGGAAGGTTCCCTATTTTCCTCATGCAGATACTATCA
TCTATTCCATCTCTACAGCAATTTGCTTCCAGGCAGCTGTCATGGAAGTTCAGACTTTGAGACCATCTTACTGGAAGTTCCTTTTAAGAC
TCACCAAGGGCAAATTTGCTGTCATGAACCGAAAAGTCCTTGATGTTTTTGGTACTGGTGCATCTAAACACTTTCAGGATTTCATCCCCA
GGTTGGATCCAAGATACACAACTGTAACACCAGAGTTGCCCACAGAGTTTTCCTGAAGATGACTGTAACTTATTAATGTGACTAAATGTT
TCATCTTGAAGAGTTAATTATGTTGAACACAAAGGAGGGGGCCCAAGCTCGAACTTCAGTGTTATTTCAGTTAGAGATACTCTTTTCATT
TGTTTTGTTTTTCTTATGAATCAGAAATTCAGAAGCTTTTTAGGAAGATGTTGCTTAATAATTAAGCTTCCTCCATAGCCAGAATAAGAT
TCTGGATCACTGTAGTGACTGACATTATATATTATTGATCAAATTATGTCCACAAGCAATATTATATAATCTACGTAGAAGTGTAATAAC
AAACAAGAGTACACTTAAAATTACTTTAAAAGATGTCTTTAGTTCATTCCAATATAATTCTTGATTAAAATTAGGATTATTTCTACATTT
TAGGATTTACAAAGGATCACGGGTACATGGATTTGGTCTATATATTTTTTTAAAGTTTTGAATTGGTATCTGTAGTAGTGGAATGTTATA
GATTTGAAGTAACTCTCCACGGACAGTGCTGCTTTCGTGTAGAGCAATTTAATTGGAGAAGTGGCCATTCTTACTTCAGGGATGCAAAGA
TGGGTCTCATACCATTTGGATAAATGTCGTGGTATCCATGCTTTTTTTCAACTAATAACATCATCTCTCTTCATGACCAGTTAATTGGGC
TATTTGGCAGCCCAGTGAACCTATGTACTAATGGCAAGTTAGGGGCAAATGGAAATGGACACATCCGATAAAGTTGAAATGTATGTTTTA
ATCTTTCACAGAAGTATTACACTTGAATATTTAAAAACAAAACTTTTAAACTTCCTATAGGTTTATGATGTTTGTTTTCATTTATATGGA
CATAATCCTTCATAGCTCAGTTTATATGCCATTGTTGTATTAGAAGGGATCAAAATCCTATGGAACAAAGTAGTCTTGGCAAGTTGGCAG
TTTGTGTCCTCTCAGCTGTTTAACTTATGTAATGGATGTTTTGCACCTGAAAACACTATAAAAATCCAGTGGTTGTTTAAAAAGTCCATT
TGTCACTAATTCCATTCAGGTTCTCCAACCTTCTTCTTGAATATCATTGTCACCATTTTTACTGTTAGAATAAAGAGGTGACACCATAAA
GTCCTGCTGATAATGAGAGTAGTTCAGGACAGCTGTGATTGAAATATGGTCGCTATTTACAGTTTTTCAGGGAAAAGTTATACTTTTCTA
TGTTAATAAAGAGCTGAAGTGGTCTACAGTTAATGTGACATGTAGGGATGATGATATTTTTAAAATACATTTTGTTGCTAAAAAGTTTTT
AGGCCAGTGCAAATTATGCAGTAGAACTTGTGTTGCAAAAGGAATTATAACCCATACTTTAAAAATGCTTAATCCCTCATATTCAATTTC
ATCAAGCCTTGTATACTTCTGCTTAAATGTAATTCAATCCTTGGTTGTTATGGCAAACAGAAACCCAACAAAAAGACAGACTCTGGTACT
ATGGTAACAGAGCCACTTTATCATTTGGTCAAAATTTGGCATTATGATTAGCTTTGTAGAACTGACCTGTTTATTTGGCAATGCTGTTAA
AGGATCATTTCGGTTTCAGACTTCAAAGTTGATTAATAAATTTAATCTTAACTTTTTATTCACTGGAATCAAAACGATGGTTGGTACTGT
GTTTACTGTTTAAAATGAAGTACTAAAGCCCTGAGAACTGCACCTCATTTTCTTTATCCAGAAATTGTGCTTATATATTTTCCTGTCAGG
TTTAAAAAGATGTTTTAATTCATAAATTATTGTTTTCATTGACATTAAAAGACTGTGATATTGAAAGATGAATTACGAAATTTGCTGAGA
TTGTTTAGTAAAATTTTGCTGGTCAAAAAGGTGTATTTCTACAATTTACCTTTTCATTTTTATAAATTGCAGTCATTTTTTTAAATTTTA
TGTAAAATGTAAAATGAAATAGCTATCATGAAGCAGAATACAATGATGAATGTATAGGTTGAGTGAATAACCAATTTGCAGTGGTGGATT
GAGAAGTCCAGTTTGATTTCATTGGGACAGACTGCAAAGTGTAGTTGTTTGAGCAAACACAAAGAAACTTTGTGTTTTTGAAGACAATCA
GAATGATTACCTTTCTACCTCTAACTAATCAGGTATTGATTGACAACTTTTTGGCATTATAAATAAAGTAAAATAGATCTCTGCATTCCA
AAATATGTTTTTTAGTTTATTTATATCCTGAAGAAATGGTAAGTTTTCACTGGAACTGATTACAGTAAACAATAATATGTCCCCTTAGTC
TTTCTGACATTTTTATATAGATTGAGATTGAAAAACCGTGCATTTGGGGCAGTGGTATTATGGTCATTTCGTTGCTATTTTCTGTTTTAA

>2107_2107_2_ADAMTS7-TMEM135_ADAMTS7_chr15_79103463_ENST00000388820_TMEM135_chr11_86947680_ENST00000340353_length(amino acids)=374AA_BP=69
MHAGRACPEPDLGPGSDRTGRTRACARGHPAAARFLPCPAAPVPAAPRLCCAPSSCSSALWLPAPPDPHQVLLFCITAAMYMFFFRCKDG
LKGFTFSALRFIVGKEEIPTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSV
GYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLA
SKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGKFAVMNRKVLDVFGTGASKHFQDFIPRLDP

--------------------------------------------------------------
>2107_2107_3_ADAMTS7-TMEM135_ADAMTS7_chr15_79103463_ENST00000388820_TMEM135_chr11_86947680_ENST00000532959_length(transcript)=1252nt_BP=311nt
CTTTTCTTTGCCTCTGCAGCGGCCAAGGGGGCGGGCCCTGCAGCCTTTGTTGCCCGCGGACCGAGCGCAGCCGAACGGAGTCGGGGCCGG
GTCGCCGGGAGCTGCACGCCGGCCGGGCATGTCCTGAGCCGGACCTGGGACCAGGCAGCGACCGGACGGGACGGACGAGAGCGTGCGCGC
GGGGTCACCCGGCGGCCGCCCGGTTCCTGCCATGCCCGGCGGCCCCAGTCCCCGCAGCCCCGCGCCTTTGCTGCGCCCCCTCCTCCTGCT
CCTCTGCGCTCTGGCTCCCGGCGCCCCCGGACCCGCACCAGGTCCTTTTGTTTTGCATCACAGCTGCCATGTACATGTTCTTTTTCAGGT
GCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGGTTCATTGTAGGGAAGGAAGAAATTCCCACACATTCTTTTTCACCAGAGG
CAGCATATGCAAAAGTGGAACAAAAGAGAGAGCAACATGAGGAAAAACCCGGAAGAATGAATATGATTGGTCTAGTCAGGAAATTTGTGG
ATTCAATATGCAAACATGGACCAAGGCATAGATGTTGCAAACATTATGAAGATAATTGCATCTCTTATTGCATTAAAGGTTTCATCAGAA
TGTTTAGCGTGGGGTACTTGATCCAGTGCTGCCTCCGAATCCCTTCTGCATTTAGGCATCTGTTTACACAGCCATCTCGGCTACTTTCTC
TCTTCTACAATAAAGAAAACTTCCAGCTTGGAGCTTTTCTTGGCTCTTTTGTTAGTATATACAAGGGTACTAGTTGCTTCCTGCGCTGGA
TCAGAAACTTAGATGATGAACTACATGCTATTATAGCTGGATTTTTGGCAGGTATATCAATGATGTTTTATAAAAGCACAACAATTTCCA
TGTATTTAGCGTCCAAATTGGTAGAGACAATGTATTTCAAAGGCATTGAAGCAGGGAAGGTTCCCTATTTTCCTCATGCAGATACTATCA
TCTATTCCATCTCTACAGCAATTTGCTTCCAGGCAGCTGTCATGGAAGTTCAGACTTTGAGACCATCTTACTGGAAGTTCCTTTTAAGAC
TCACCAAGGGCAAATTTGCTGTCATGAACCGAAAAGTCCTTGATGTTTTTGGTACTGGTGCATCTAAACACTTTCAGGATTTCATCCCCA

>2107_2107_3_ADAMTS7-TMEM135_ADAMTS7_chr15_79103463_ENST00000388820_TMEM135_chr11_86947680_ENST00000532959_length(amino acids)=374AA_BP=69
MHAGRACPEPDLGPGSDRTGRTRACARGHPAAARFLPCPAAPVPAAPRLCCAPSSCSSALWLPAPPDPHQVLLFCITAAMYMFFFRCKDG
LKGFTFSALRFIVGKEEIPTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSV
GYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLA
SKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGKFAVMNRKVLDVFGTGASKHFQDFIPRLDP

--------------------------------------------------------------
>2107_2107_4_ADAMTS7-TMEM135_ADAMTS7_chr15_79103463_ENST00000388820_TMEM135_chr11_86947680_ENST00000535167_length(transcript)=1379nt_BP=311nt
CTTTTCTTTGCCTCTGCAGCGGCCAAGGGGGCGGGCCCTGCAGCCTTTGTTGCCCGCGGACCGAGCGCAGCCGAACGGAGTCGGGGCCGG
GTCGCCGGGAGCTGCACGCCGGCCGGGCATGTCCTGAGCCGGACCTGGGACCAGGCAGCGACCGGACGGGACGGACGAGAGCGTGCGCGC
GGGGTCACCCGGCGGCCGCCCGGTTCCTGCCATGCCCGGCGGCCCCAGTCCCCGCAGCCCCGCGCCTTTGCTGCGCCCCCTCCTCCTGCT
CCTCTGCGCTCTGGCTCCCGGCGCCCCCGGACCCGCACCAGGTCCTTTTGTTTTGCATCACAGCTGCCATGTACATGTTCTTTTTCAGGT
GCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGGTTCATTGTAGGGAAGGAAGAAATTCCCACACATTCTTTTTCACCAGAGG
CAGCATATGCAAAAGTGGAACAAAAGAGAGAGCAACATGAGGAAAAACCCGGAAGAATGAATATGATTGGTCTAGTCAGGAAATTTGTGG
ATTCAATATGCAAACATGGACCAAGGCATAGATGTTGCAAACATTATGAAGATAATTGCATCTCTTATTGCATTAAAGGTTTCATCAGAA
TGTTTAGCGTGGGGTACTTGATCCAGTGCTGCCTCCGAATCCCTTCTGCATTTAGGCATCTGTTTACACAGCCATCTCGGCTACTTTCTC
TCTTCTACAATAAAGAAAACTTCCAGCTTGGAGCTTTTCTTGGCTCTTTTGTTAGTATATACAAGGGTACTAGTTGCTTCCTGCGCTGGA
TCAGAAACTTAGATGATGAACTACATGCTATTATAGCTGGATTTTTGGCAGGTATATCAATGATGTTTTATAAAAGCACAACAATTTCCA
TGTATTTAGCGTCCAAATTGGTAGAGACAATGTATTTCAAAGGCATTGAAGCAGGGAAGGTTCCCTATTTTCCTCATGCAGATACTATCA
TCTATTCCATCTCTACAGCAATTTGCTTCCAGGCAGCTGTCATGGAAGTTCAGACTTTGAGACCATCTTACTGGAAGTTCCTTTTAAGAC
TCACCAAGGGCAAATTTGCTGTCATGAACCGAAAAGTCCTTGATGTTTTTGGTACTGGTGCATCTAAACACTTTCAGGATTTCATCCCCA
GGTTGGATCCAAGATACACAACTGTAACACCAGAGTTGCCCACAGAGTTTTCCTGAAGATGACTGTAACTTATTAATGTGACTAAATGTT
TCATCTTGAAGAGTTAATTATGTTGAACACAAAGGAGGGGGCCCAAGCTCGAACTTCAGTGTTATTTCAGTTAGAGATACTCTTTTCATT

>2107_2107_4_ADAMTS7-TMEM135_ADAMTS7_chr15_79103463_ENST00000388820_TMEM135_chr11_86947680_ENST00000535167_length(amino acids)=374AA_BP=69
MHAGRACPEPDLGPGSDRTGRTRACARGHPAAARFLPCPAAPVPAAPRLCCAPSSCSSALWLPAPPDPHQVLLFCITAAMYMFFFRCKDG
LKGFTFSALRFIVGKEEIPTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSV
GYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLA
SKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGKFAVMNRKVLDVFGTGASKHFQDFIPRLDP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ADAMTS7-TMEM135


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADAMTS7-TMEM135


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADAMTS7-TMEM135


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADAMTS7C0010054Coronary Arteriosclerosis1CTD_human
HgeneADAMTS7C0032460Polycystic Ovary Syndrome1CTD_human
HgeneADAMTS7C1136382Sclerocystic Ovaries1CTD_human
HgeneADAMTS7C1956346Coronary Artery Disease1CTD_human
TgeneC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneC0017636Glioblastoma1CTD_human
TgeneC0020796Profound Mental Retardation1CTD_human
TgeneC0025363Mental Retardation, Psychosocial1CTD_human
TgeneC0334588Giant Cell Glioblastoma1CTD_human
TgeneC0917816Mental deficiency1CTD_human
TgeneC1621958Glioblastoma Multiforme1CTD_human
TgeneC3714756Intellectual Disability1CTD_human