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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:BAZ1A-NKX2-1 (FusionGDB2 ID:HG11177TG7080) |
Fusion Gene Summary for BAZ1A-NKX2-1 |
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Fusion gene information | Fusion gene name: BAZ1A-NKX2-1 | Fusion gene ID: hg11177tg7080 | Hgene | Tgene | Gene symbol | BAZ1A | NKX2-1 | Gene ID | 11177 | 7080 |
Gene name | bromodomain adjacent to zinc finger domain 1A | NK2 homeobox 1 | |
Synonyms | ACF1|WALp1|WCRF180|hACF1 | BCH|BHC|NK-2|NKX2.1|NKX2A|NMTC1|T/EBP|TEBP|TITF1|TTF-1|TTF1 | |
Cytomap | ('BAZ1A')('NKX2-1') 14q13.1-q13.2 | 14q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | bromodomain adjacent to zinc finger domain protein 1AATP-dependent chromatin remodeling proteinATP-utilizing chromatin assembly and remodeling factor 1CHRAC subunit ACF1hWALp1williams syndrome transcription factor-related chromatin-remodeling factor | homeobox protein Nkx-2.1NK-2 homolog Ahomeobox protein NK-2 homolog Athyroid nuclear factor 1thyroid transcription factor 1thyroid-specific enhancer-binding protein | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000358716, ENST00000360310, ENST00000382422, ENST00000553853, | ||
Fusion gene scores | * DoF score | 12 X 9 X 5=540 | 1 X 1 X 1=1 |
# samples | 12 | 1 | |
** MAII score | log2(12/540*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: BAZ1A [Title/Abstract] AND NKX2-1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | BAZ1A(35331250)-NKX2-1(36988575), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | BAZ1A-NKX2-1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BAZ1A-NKX2-1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BAZ1A-NKX2-1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BAZ1A-NKX2-1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BAZ1A-NKX2-1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. BAZ1A-NKX2-1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. BAZ1A-NKX2-1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. BAZ1A-NKX2-1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. BAZ1A-NKX2-1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. BAZ1A-NKX2-1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. BAZ1A-NKX2-1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. BAZ1A-NKX2-1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BAZ1A | GO:0006261 | DNA-dependent DNA replication | 12434153 |
Tgene | NKX2-1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 23143308 |
Tgene | NKX2-1 | GO:0010628 | positive regulation of gene expression | 16960125 |
Tgene | NKX2-1 | GO:0010719 | negative regulation of epithelial to mesenchymal transition | 19293183 |
Tgene | NKX2-1 | GO:0030336 | negative regulation of cell migration | 19293183 |
Tgene | NKX2-1 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 19293183 |
Tgene | NKX2-1 | GO:0045893 | positive regulation of transcription, DNA-templated | 14960358 |
Tgene | NKX2-1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7559607|7713914|16960125 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LUAD | TCGA-L9-A444-01A | BAZ1A | chr14 | 35331250 | - | NKX2-1 | chr14 | 36988575 | - |
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Fusion Gene ORF analysis for BAZ1A-NKX2-1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000358716 | ENST00000498187 | BAZ1A | chr14 | 35331250 | - | NKX2-1 | chr14 | 36988575 | - |
5CDS-5UTR | ENST00000358716 | ENST00000518149 | BAZ1A | chr14 | 35331250 | - | NKX2-1 | chr14 | 36988575 | - |
5CDS-5UTR | ENST00000358716 | ENST00000522719 | BAZ1A | chr14 | 35331250 | - | NKX2-1 | chr14 | 36988575 | - |
5CDS-5UTR | ENST00000360310 | ENST00000498187 | BAZ1A | chr14 | 35331250 | - | NKX2-1 | chr14 | 36988575 | - |
5CDS-5UTR | ENST00000360310 | ENST00000518149 | BAZ1A | chr14 | 35331250 | - | NKX2-1 | chr14 | 36988575 | - |
5CDS-5UTR | ENST00000360310 | ENST00000522719 | BAZ1A | chr14 | 35331250 | - | NKX2-1 | chr14 | 36988575 | - |
5CDS-5UTR | ENST00000382422 | ENST00000498187 | BAZ1A | chr14 | 35331250 | - | NKX2-1 | chr14 | 36988575 | - |
5CDS-5UTR | ENST00000382422 | ENST00000518149 | BAZ1A | chr14 | 35331250 | - | NKX2-1 | chr14 | 36988575 | - |
5CDS-5UTR | ENST00000382422 | ENST00000522719 | BAZ1A | chr14 | 35331250 | - | NKX2-1 | chr14 | 36988575 | - |
5UTR-3CDS | ENST00000553853 | ENST00000354822 | BAZ1A | chr14 | 35331250 | - | NKX2-1 | chr14 | 36988575 | - |
5UTR-5UTR | ENST00000553853 | ENST00000498187 | BAZ1A | chr14 | 35331250 | - | NKX2-1 | chr14 | 36988575 | - |
5UTR-5UTR | ENST00000553853 | ENST00000518149 | BAZ1A | chr14 | 35331250 | - | NKX2-1 | chr14 | 36988575 | - |
5UTR-5UTR | ENST00000553853 | ENST00000522719 | BAZ1A | chr14 | 35331250 | - | NKX2-1 | chr14 | 36988575 | - |
Frame-shift | ENST00000358716 | ENST00000354822 | BAZ1A | chr14 | 35331250 | - | NKX2-1 | chr14 | 36988575 | - |
Frame-shift | ENST00000360310 | ENST00000354822 | BAZ1A | chr14 | 35331250 | - | NKX2-1 | chr14 | 36988575 | - |
In-frame | ENST00000382422 | ENST00000354822 | BAZ1A | chr14 | 35331250 | - | NKX2-1 | chr14 | 36988575 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000382422 | BAZ1A | chr14 | 35331250 | - | ENST00000354822 | NKX2-1 | chr14 | 36988575 | - | 2730 | 720 | 28 | 1848 | 606 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000382422 | ENST00000354822 | BAZ1A | chr14 | 35331250 | - | NKX2-1 | chr14 | 36988575 | - | 0.01518999 | 0.98481005 |
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Fusion Genomic Features for BAZ1A-NKX2-1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for BAZ1A-NKX2-1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:35331250/chr14:36988575) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000358716 | - | 3 | 26 | 22_128 | 130 | 1525.0 | Domain | WAC |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000360310 | - | 3 | 27 | 22_128 | 130 | 1557.0 | Domain | WAC |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000382422 | - | 2 | 26 | 22_128 | 130 | 1557.0 | Domain | WAC |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000358716 | - | 3 | 26 | 1_128 | 130 | 1525.0 | Region | Note=Required for association with the CHRAC1/POLE3 complex |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000360310 | - | 3 | 27 | 1_128 | 130 | 1557.0 | Region | Note=Required for association with the CHRAC1/POLE3 complex |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000382422 | - | 2 | 26 | 1_128 | 130 | 1557.0 | Region | Note=Required for association with the CHRAC1/POLE3 complex |
Tgene | NKX2-1 | chr14:35331250 | chr14:36988575 | ENST00000354822 | 0 | 3 | 234_243 | 25 | 402.0 | Compositional bias | Note=Poly-Gly | |
Tgene | NKX2-1 | chr14:35331250 | chr14:36988575 | ENST00000354822 | 0 | 3 | 246_253 | 25 | 402.0 | Compositional bias | Note=Poly-Gln | |
Tgene | NKX2-1 | chr14:35331250 | chr14:36988575 | ENST00000354822 | 0 | 3 | 294_303 | 25 | 402.0 | Compositional bias | Note=Poly-Ala | |
Tgene | NKX2-1 | chr14:35331250 | chr14:36988575 | ENST00000498187 | 0 | 2 | 234_243 | 0 | 372.0 | Compositional bias | Note=Poly-Gly | |
Tgene | NKX2-1 | chr14:35331250 | chr14:36988575 | ENST00000498187 | 0 | 2 | 246_253 | 0 | 372.0 | Compositional bias | Note=Poly-Gln | |
Tgene | NKX2-1 | chr14:35331250 | chr14:36988575 | ENST00000498187 | 0 | 2 | 294_303 | 0 | 372.0 | Compositional bias | Note=Poly-Ala | |
Tgene | NKX2-1 | chr14:35331250 | chr14:36988575 | ENST00000518149 | 0 | 3 | 234_243 | 0 | 372.0 | Compositional bias | Note=Poly-Gly | |
Tgene | NKX2-1 | chr14:35331250 | chr14:36988575 | ENST00000518149 | 0 | 3 | 246_253 | 0 | 372.0 | Compositional bias | Note=Poly-Gln | |
Tgene | NKX2-1 | chr14:35331250 | chr14:36988575 | ENST00000518149 | 0 | 3 | 294_303 | 0 | 372.0 | Compositional bias | Note=Poly-Ala | |
Tgene | NKX2-1 | chr14:35331250 | chr14:36988575 | ENST00000522719 | 1 | 4 | 234_243 | 0 | 372.0 | Compositional bias | Note=Poly-Gly | |
Tgene | NKX2-1 | chr14:35331250 | chr14:36988575 | ENST00000522719 | 1 | 4 | 246_253 | 0 | 372.0 | Compositional bias | Note=Poly-Gln | |
Tgene | NKX2-1 | chr14:35331250 | chr14:36988575 | ENST00000522719 | 1 | 4 | 294_303 | 0 | 372.0 | Compositional bias | Note=Poly-Ala | |
Tgene | NKX2-1 | chr14:35331250 | chr14:36988575 | ENST00000354822 | 0 | 3 | 161_220 | 25 | 402.0 | DNA binding | Homeobox | |
Tgene | NKX2-1 | chr14:35331250 | chr14:36988575 | ENST00000498187 | 0 | 2 | 161_220 | 0 | 372.0 | DNA binding | Homeobox | |
Tgene | NKX2-1 | chr14:35331250 | chr14:36988575 | ENST00000518149 | 0 | 3 | 161_220 | 0 | 372.0 | DNA binding | Homeobox | |
Tgene | NKX2-1 | chr14:35331250 | chr14:36988575 | ENST00000522719 | 1 | 4 | 161_220 | 0 | 372.0 | DNA binding | Homeobox |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000358716 | - | 3 | 26 | 306_397 | 130 | 1525.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000358716 | - | 3 | 26 | 634_709 | 130 | 1525.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000360310 | - | 3 | 27 | 306_397 | 130 | 1557.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000360310 | - | 3 | 27 | 634_709 | 130 | 1557.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000382422 | - | 2 | 26 | 306_397 | 130 | 1557.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000382422 | - | 2 | 26 | 634_709 | 130 | 1557.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000358716 | - | 3 | 26 | 1239_1257 | 130 | 1525.0 | Compositional bias | Note=Glu-rich |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000358716 | - | 3 | 26 | 487_491 | 130 | 1525.0 | Compositional bias | Note=Poly-Glu |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000360310 | - | 3 | 27 | 1239_1257 | 130 | 1557.0 | Compositional bias | Note=Glu-rich |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000360310 | - | 3 | 27 | 487_491 | 130 | 1557.0 | Compositional bias | Note=Poly-Glu |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000382422 | - | 2 | 26 | 1239_1257 | 130 | 1557.0 | Compositional bias | Note=Glu-rich |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000382422 | - | 2 | 26 | 487_491 | 130 | 1557.0 | Compositional bias | Note=Poly-Glu |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000358716 | - | 3 | 26 | 1446_1516 | 130 | 1525.0 | Domain | Bromo |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000358716 | - | 3 | 26 | 422_487 | 130 | 1525.0 | Domain | DDT |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000360310 | - | 3 | 27 | 1446_1516 | 130 | 1557.0 | Domain | Bromo |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000360310 | - | 3 | 27 | 422_487 | 130 | 1557.0 | Domain | DDT |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000382422 | - | 2 | 26 | 1446_1516 | 130 | 1557.0 | Domain | Bromo |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000382422 | - | 2 | 26 | 422_487 | 130 | 1557.0 | Domain | DDT |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000358716 | - | 3 | 26 | 1148_1198 | 130 | 1525.0 | Zinc finger | PHD-type |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000360310 | - | 3 | 27 | 1148_1198 | 130 | 1557.0 | Zinc finger | PHD-type |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000382422 | - | 2 | 26 | 1148_1198 | 130 | 1557.0 | Zinc finger | PHD-type |
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Fusion Gene Sequence for BAZ1A-NKX2-1 |
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>9015_9015_1_BAZ1A-NKX2-1_BAZ1A_chr14_35331250_ENST00000382422_NKX2-1_chr14_36988575_ENST00000354822_length(transcript)=2730nt_BP=720nt CCCGCACTGCCCCCCGCGGCGGGGCGTCCTGCCCCATTGTGAGGCGGCGGCAGGACGAGAGGAGGTAGGGCGCGCTCGGGGGGCAGGGGC GGCGGCGGCTCCGCTCGCTCGACACCCGGGCAGCGGCAGGAACGAACTCGGCTCCGGTAGCGGCCGCGGCGCGTCAGTCACACAAAAGGC AGCCGAGCTTCTCCCAGCGCGCGGACCGGCCCACGCTGCCGCCGAGGGCTCCCCACCTTACCGGCTTTCCTTTCCCTCCAATTTTGATAG GGAAGCGGGGCCGGCGCGGGCGGCCGAGGGTCCAGGCGAGCCCGCGGGCGGACGGGAGATGCCGCTGCTACACCGAAAGCCGTTTGTGAG ACAGAAGCCGCCCGCGGACCTGCGGCCCGACGAGGAAGTTTTCTACTGTAAAGTCACCAACGAGATCTTCCGCCACTACGATGACTTTTT TGAACGAACCATTCTGTGCAACAGCCTTGTGTGGAGTTGTGCTGTGACGGGTAGACCTGGACTGACGTATCAGGAAGCACTTGAGTCAGA AAAAAAAGCAAGACAGAATCTTCAGAGTTTTCCAGAACCACTAATTATTCCAGTTTTATACTTGACCAGCCTTACCCATCGTTCGCGCTT ACATGAAATTTGTGATGATATCTTTGCATATGTCAAGGATCGATATTTTGTCGAAGAAACTGTGGAAGTCATTAGGAACAATGGTGCAAG CCGCCGCCGAATCATGTCGATGAGTCCAAAGCACACGACTCCGTTCTCAGTGTCTGACATCTTGAGTCCCCTGGAGGAAAGCTACAAGAA AGTGGGCATGGAGGGCGGCGGCCTCGGGGCTCCGCTGGCGGCGTACAGGCAGGGCCAGGCGGCACCGCCAACAGCGGCCATGCAGCAGCA CGCCGTGGGGCACCACGGCGCCGTCACCGCCGCCTACCACATGACGGCGGCGGGGGTGCCCCAGCTCTCGCACTCCGCCGTGGGGGGCTA CTGCAACGGCAACCTGGGCAACATGAGCGAGCTGCCGCCGTACCAGGACACCATGAGGAACAGCGCCTCTGGCCCCGGATGGTACGGCGC CAACCCAGACCCGCGCTTCCCCGCCATCTCCCGCTTCATGGGCCCGGCGAGCGGCATGAACATGAGCGGCATGGGCGGCCTGGGCTCGCT GGGGGACGTGAGCAAGAACATGGCCCCGCTGCCAAGCGCGCCGCGCAGGAAGCGCCGGGTGCTCTTCTCGCAGGCGCAGGTGTACGAGCT GGAGCGACGCTTCAAGCAACAGAAGTACCTGTCGGCGCCGGAGCGCGAGCACCTGGCCAGCATGATCCACCTGACGCCCACGCAGGTCAA GATCTGGTTCCAGAACCACCGCTACAAAATGAAGCGCCAGGCCAAGGACAAGGCGGCGCAGCAGCAACTGCAGCAGGACAGCGGCGGCGG CGGGGGCGGCGGGGGCACCGGGTGCCCGCAGCAGCAACAGGCTCAGCAGCAGTCGCCGCGACGCGTGGCGGTGCCGGTCCTGGTGAAAGA CGGCAAACCGTGCCAGGCGGGTGCCCCCGCGCCGGGCGCCGCCAGCCTACAAGGCCACGCGCAGCAGCAGGCGCAGCACCAGGCGCAGGC CGCGCAGGCGGCGGCAGCGGCCATCTCCGTGGGCAGCGGTGGCGCCGGCCTTGGCGCACACCCGGGCCACCAGCCAGGCAGCGCAGGCCA GTCTCCGGACCTGGCGCACCACGCCGCCAGCCCCGCGGCGCTGCAGGGCCAGGTATCCAGCCTGTCCCACCTGAACTCCTCGGGCTCGGA CTACGGCACCATGTCCTGCTCCACCTTGCTATACGGTCGGACCTGGTGAGAGGACGCCGGGCCGGCCCTAGCCCAGCGCTCTGCCTCACC GCTTCCCTCCTGCCCGCCACACAGACCACCATCCACCGCTGCTCCACGCGCTTCGACTTTTCTTAACAACCTGGCCGCGTTTAGACCAAG GAACAAAAAAACCACAAAGGCCAAACTGCTGGACGTCTTTCTTTTTTTCCCCCCCTAAAATTTGTGGGTTTTTTTTTTTAAAAAAAGAAA ATGAAAAACAACCAAGCGCATCCAATCTCAAGGAATCTTTAAGCAGAGAAGGGCATAAAACAGCTTTGGGGTGTCTTTTTTTGGTGATTC AAATGGGTTTTCCACGCTAGGGCGGGGCACAGATTGGAGAGGGCTCTGTGCTGACATGGCTCTGGACTCTAAAGACCAAACTTCACTCTG GGCACACTCTGCCAGCAAAGAGGACTCGCTTGTAAATACCAGGATTTTTTTTTTTTTTTGAAGGGAGGACGGGAGCTGGGGAGAGGAAAG AGTCTTCAACATAACCCACTTGTCACTGACACAAAGGAAGTGCCCCCTCCCCGGCACCCTCTGGCCGCCTAGGCTCAGCGGCGACCGCCC TCCGCGAAAATAGTTTGTTTAATGTGAACTTGTAGCTGTAAAACGCTGTCAAAAGTTGGACTAAATGCCTAGTTTTTAGTAATCTGTACA TTTTGTTGTAAAAAGAAAAACCACTCCCAGTCCCCAGCCCTTCACATTTTTTATGGGCATTGACAAATCTGTGTATATTATTTGGCAGTT TGGTATTTGCGGCGTCAGTCTTTTTCTGTTGTAACTTATGTAGATATTTGGCTTAAATATAGTTCCTAAGAAGCTTCTAATAAATTATAC >9015_9015_1_BAZ1A-NKX2-1_BAZ1A_chr14_35331250_ENST00000382422_NKX2-1_chr14_36988575_ENST00000354822_length(amino acids)=606AA_BP=230 MPHCEAAAGREEVGRARGAGAAAAPLARHPGSGRNELGSGSGRGASVTQKAAELLPARGPAHAAAEGSPPYRLSFPSNFDREAGPARAAE GPGEPAGGREMPLLHRKPFVRQKPPADLRPDEEVFYCKVTNEIFRHYDDFFERTILCNSLVWSCAVTGRPGLTYQEALESEKKARQNLQS FPEPLIIPVLYLTSLTHRSRLHEICDDIFAYVKDRYFVEETVEVIRNNGASRRRIMSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLG APLAAYRQGQAAPPTAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAI SRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYK MKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQHQAQAAQAAAAAIS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for BAZ1A-NKX2-1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000358716 | - | 3 | 26 | 667_933 | 130.66666666666666 | 1525.0 | SMARCA5 |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000360310 | - | 3 | 27 | 667_933 | 130.66666666666666 | 1557.0 | SMARCA5 |
Hgene | BAZ1A | chr14:35331250 | chr14:36988575 | ENST00000382422 | - | 2 | 26 | 667_933 | 130.66666666666666 | 1557.0 | SMARCA5 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for BAZ1A-NKX2-1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for BAZ1A-NKX2-1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0393584 | Benign Hereditary Chorea | 9 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C1970269 | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | 8 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0019284 | Diaphragmatic Hernia | 2 | CTD_human | |
Tgene | C1859098 | Chorea, Benign Familial | 2 | ORPHANET | |
Tgene | C0010308 | Congenital Hypothyroidism | 1 | GENOMICS_ENGLAND | |
Tgene | C0019569 | Hirschsprung Disease | 1 | GENOMICS_ENGLAND | |
Tgene | C0024115 | Lung diseases | 1 | CTD_human | |
Tgene | C0035220 | Respiratory Distress Syndrome, Newborn | 1 | GENOMICS_ENGLAND | |
Tgene | C0238463 | Papillary thyroid carcinoma | 1 | CTD_human;ORPHANET | |
Tgene | C0749420 | Thyroid Agenesis | 1 | ORPHANET | |
Tgene | C3161105 | Neuroendocrine cell hyperplasia of infancy | 1 | GENOMICS_ENGLAND | |
Tgene | C3806482 | Recurrent respiratory infections | 1 | GENOMICS_ENGLAND | |
Tgene | C4721429 | THYROID CANCER, NONMEDULLARY, 1 | 1 | GENOMICS_ENGLAND;UNIPROT |